! This matrix is the standard MDM78, but with additional types for consensus alignment ! derived by (approximate) averaging of the included types. ! ~ - Acidic. ! ! - Hydrophobic. ! @ - Amido. ! # - Aromatic. ! $ - Basic. ! % - Hydroxyl containing. ! ^ - Proline. ! & - Sulphur containing. C S T P A G N D E Q B Z H R K M I L V F Y W - X ? ~ ! @ # $ % ^ & 20 10 8 7 8 7 6 5 5 5 5 5 7 6 5 5 8 4 8 6 10 2 10 10 10 5 8 10 6 6 9 7 13 10 12 11 11 11 11 11 10 10 9 10 10 9 10 10 8 9 7 9 7 7 8 10 10 10 10 8 10 7 10 10 11 9 8 11 13 10 11 10 10 10 10 9 10 10 9 9 10 9 10 8 10 7 7 5 10 10 10 10 8 10 7 9 10 10 9 7 11 10 16 11 9 9 9 9 10 9 10 10 10 9 8 8 7 9 5 5 4 10 10 10 9 7 10 5 10 9 16 8 8 11 11 11 12 11 10 10 10 10 10 10 9 8 9 9 9 8 10 6 7 4 10 10 10 10 7 10 6 9 9 11 9 7 11 10 9 11 15 10 11 10 9 10 10 8 7 8 7 7 6 9 5 5 3 10 10 10 11 7 10 5 8 8 9 7 6 11 10 9 10 10 12 12 11 11 12 11 12 10 11 8 8 7 8 6 8 6 10 10 10 12 7 10 7 11 9 9 7 5 10 10 9 10 11 12 14 13 12 13 12 11 9 10 7 8 6 8 4 6 3 10 10 10 14 7 10 5 10 8 9 6 5 10 10 9 10 10 11 13 14 12 12 13 11 9 10 8 8 7 8 5 6 3 10 10 10 14 7 10 5 10 8 9 7 5 9 9 10 10 9 11 12 12 14 11 13 13 11 11 9 8 8 8 5 6 5 10 10 10 12 7 10 6 12 8 10 8 5 10 10 9 10 10 12 13 12 11 13 11 11 10 10 8 8 6 8 5 7 4 10 10 10 13 7 10 6 10 8 9 7 5 10 10 10 10 10 11 12 13 13 11 14 12 10 10 8 8 8 8 5 6 4 10 10 10 13 7 10 5 11 9 10 7 7 9 9 10 9 8 12 11 11 13 11 12 16 12 10 8 8 8 8 8 10 7 10 10 10 11 8 10 9 13 9 10 8 6 10 9 10 8 7 10 9 9 11 10 10 12 16 13 10 8 7 8 6 6 12 10 10 10 9 8 10 8 14 9 10 8 5 10 10 9 9 8 11 10 10 11 10 10 10 13 15 10 8 7 8 5 6 7 10 10 10 10 7 10 6 13 8 9 8 5 8 9 8 9 7 8 7 8 9 8 8 8 10 10 16 12 14 12 10 8 6 10 10 10 8 11 10 8 10 8 8 11 8 9 10 8 9 7 8 8 8 8 8 8 8 8 8 12 15 12 14 11 9 5 10 10 10 8 13 10 9 9 9 8 10 4 7 8 7 8 6 7 6 7 8 6 8 8 7 7 14 12 16 12 12 9 8 10 10 10 7 13 10 9 8 8 7 9 8 9 10 9 10 9 8 8 8 8 8 8 8 8 8 12 14 12 14 9 8 4 10 10 10 8 13 10 8 9 9 9 10 6 7 7 5 6 5 6 4 5 5 5 5 8 6 5 10 11 12 9 19 17 10 10 10 10 5 14 10 18 7 10 5 8 10 7 7 5 7 5 8 6 6 6 7 6 10 6 6 8 9 9 8 17 20 10 10 10 10 6 15 10 16 7 11 5 9 2 8 5 4 4 3 6 3 3 5 4 4 7 12 7 6 5 8 4 10 10 27 10 10 10 3 17 10 16 8 8 4 4 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 19 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 19 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 19 10 10 10 5 10 10 9 10 11 12 14 14 12 13 13 11 9 10 8 8 7 8 5 6 3 10 10 10 14 10 10 6 19 9 9 7 8 8 8 7 7 7 7 7 7 7 7 7 8 8 7 11 13 13 13 14 15 17 10 10 10 10 14 10 15 8 10 7 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 19 10 10 10 6 7 7 5 6 5 7 5 5 6 6 5 9 8 6 8 9 9 8 18 16 16 10 10 10 6 15 10 16 8 10 5 7 6 10 9 10 9 8 11 10 10 12 10 11 13 14 13 10 9 8 9 7 7 8 19 19 19 19 8 19 8 15 9 10 8 9 10 10 9 9 8 9 8 8 8 8 9 9 9 8 8 9 8 9 10 11 8 10 10 10 9 10 10 10 9 14 9 9 7 11 10 16 11 9 9 9 9 10 9 10 10 10 9 8 8 7 9 5 5 4 10 10 10 9 7 10 5 10 9 16 8 13 9 9 8 9 7 7 6 7 8 7 7 8 8 8 11 10 9 10 8 9 4 10 10 10 7 10 10 7 8 9 8 13