Last updated 05.01.98 --------------------- Note: alignments within CDRs are arbitrary. Kabat <--H1-> <-------H2--------> <------H3--------------> AbM <----H1----> <----H2----> <------H3--------------> Chothia <--H1-> <--H2--> <------H3--------------> * 1aag EVML-VESGGGLVQPGGSLRLSCAAS GFTFSRYA--MS WVRQPPGKRLEWVA TIS--SGGSHTFHPDSVKG RFIISRDNAKNTLYLQMNALRAEDTAIYYCAR PPLISLVADYAM----------DY WGAGTTVTVSS 1acy QVKL-QESGPAVIKPSQSLSLTCIVS GFSITRTNYCWH WIRQAPGKGLEWMG RIC---YEGSIYYSPSIKS RSTISRDTSLNKFFIQLISVTNEDTAMYYCSR ENHMYETYF-------------DV WGQGTTVTVSS 1afv QVQL-QQPGSVLVRPGASVKLSCKAS GYTFTSSW--IH WAKQRPGQGLEWIG EIH--PNSGNTNYNEKFKG KATLTVDTSSSTAYVDLSSLTSEDSAVYYCAR WRYGSPYYF-------------DY WGQGTTLTVSS 1ai1 QVKL-QESGPAVIKPSQSLSLTCIVS GFSITRTNYCWH WIRQAPGKGLEWMG RIC---YEGSIYYSPSIKS RSTISRDTSLNKFFIQLISVTNEDTAMYYCSR ENHMYETYF-------------DV WGQGTTVTVSS 1aif EVKL-QESGGGLVQPGGSMKLSCVAS GFTFNNYW--MS WVRQSPEKGLEWVA EIRLNSDNFATHYAESVKG KFIISRDDSKSRLYLQMNSLRAEDTGIYYCVL RPLFYYAV--------------DY WGQGTSVTVSS 1aj7 QVQL-QQSGAELVKPGASVKLSCTAS GFNIKDTY--MH WVKQRPEQGLEWIG RID--PANGNTKYDPKFQG KATITADTSSNTAYLQLSSLTSEDTAVYYCAS YYG-------------------IY WGQGTTLTVSS 1ap2 EVQL-QQSGAELVRPGASVKLSCTAS GFNIKDDF--MH WVKQRPEQGLEWIG RID--PANDNTKYAPKFQD KATIIADTSSNTAYLQLSSLTSEDTAVYYCAR REVYSYYSPL------------DV WGAGTTVTVP 1baf DVQL-QESGPGLVKPSQSQSLTCTVT GYSITSDYA-WN WIRQFPGNKLEWMG YMS---YSGSTRYNPSLRS RISITRDTSKNQFFLQLKSVTTEDTATYFCAR GWPL------------------AY WGQGTQVSVSE 1bbd EVQL-QQSGAELVRPGASVKLSCTTS GFNIKDIY--IH WVKQRPEQGLEWIG RLD--PANGYTKYDPKFQG KATITVDTSSNTAYLHLSSLTSEDTAVYYCDG YYSYYDM---------------DY WGPGTSVTVSS 1bbj EVQL-QQSDAELVKPGASVKISCKAS GYTFTDHA--IH WAKQKPEQGLEWIG YIS--PGNDDIKYNEKFKG KATLTADKSSSTAYMQLNSLTSEDSAVYFCKR SYY-------------------GH WGQGTTLTVSS 1bfv QVQL-QESGGGLVNLGGSMTLSCVAS GFTFNTYY--MS WVRQTPEKTLELVA AIN--SDGEPIYYPDTLKG RVTISRDNAKKTLYLQMSSLNFEDTALYYCAR LNYAVYGM--------------DY WGQGTTVTVSS 1bql -VQL-QQSGAELMKPGASVKISCKAS GYTFSDYW--IE WVKQRPGHGLEWIG EIL--PGSGSTNYHERFKG KATFTADTSSSTAYMQLNSLTSEDSGVYYCLH GNYDF-----------------DG WGQGTTLTVSS 1cbv EVQP-VETGGGLVQPKGSLKLSCAAS GFSFNTNA--MN WVRQAPGKGLEWVA RIRSKSNNYATYYADSVKD RFTISRDDSQNMLYLQMNNLKTEDTAMYYCVR DQTGTAWF--------------AY WGQGTLVTVSA 1cfv QVQL-QESGGGLVNLGGSMTLSCVAS GFTFNTYY--MS WVRQTPEKTLELVA AIN--SDGEPIYYPDTLKG RVTISRDNAKKTLYLQMSSLNFEDTALYYCAR LNYAVYGM--------------DY WGQGTTVTVSS 1cgs RVQL-LESGAELMKPGASVQISCKAT GYTFSEYW--IE WVKERPGHGLEWIG EIL--PGSGRTNYREKFKG KATFTADTSSNTAYMQLSSLTSEDSAVYYCTR GYSSM-----------------DY WGQGTSVTVSA 1clo EVKL-VESGGGLVQPGGSLRLSCATS GFTFTDYY--MN WVRQPPGKALEWLG FIGNKANGYTTEYSASVKG RFTISRDKSQSILYLQMNTLRAEDSATYYCTR DRGLRFYF--------------DY WGQGTTLTVSS 1cly EVNL-VESGGGLVQPGGSLKVSCVTS GFTFSDYY--MY WVRQTPEKRLEWVA YIS--QGGDITDYPDTVKG RFTISRDNAKNSLYLQMSRLKSEDTAMYYCAR GLDDGAWF--------------AY WGQGTLVTVS- 1clz EVNL-VESGGGLVQPGGSLKVSCVTS GFTFSDYY--MY WVRQTPEKRLEWVA YIS--QGGDITDYPDTVKG RFTISRDNAKNSLYLQMSRLKSEDTAMYYCAR GLDDGAWF--------------AY WGQGTLVTVS- 1dba QIQL-VQSGPELKKPGETVKISCKAS GYAFTNYG--VN WVKEAPGKELKWMG WIN--IYTGEPTYVDDFKG RFAFSLETSASTAYLEINNLKNEDTATYFCTR GDYVNWYF--------------DV WGAGTTVTVSS 1dbb QIQL-VQSGPELKKPGETVKISCKAS GYAFTNYG--VN WVKEAPGKELKWMG WIN--IYTGEPTYVDDFKG RFAFSLETSASTAYLEINNLKNEDTATYFCTR GDYVNWYF--------------DV WGAGTTVTVSS 1dbj QIQL-VQSGPELKKPGETVKISCKAS GYAFTNYG--VN WVKEAPGKELKWMG WIN--IYTGEPTYVDDFKG RFAFSLETSASTAYLEINNLKNEDTATYFCTR GDYVNWYF--------------DV WGAGTTVTVSS 1dbk QIQL-VQSGPELKKPGETVKISCKAS GYAFTNYG--VN WVKEAPGKELKWMG WIN--IYTGEPTYVDDFKG RFAFSLETSASTAYLEINNLKNEDTATYFCTR GDYVNWYF--------------DV WGAGTTVTVSS 1dbm QIQL-VQSGPELKKPGETVKISCKAS GYAFTNYG--VN WVKEAPGKELKWMG WIN--IYTGEPTYVDDFKG RFAFSLETSASTAYLEINNLKNEDTATYFCTR GDYVNWYF--------------DV WGAGTTVTVSS 1dfb EVQL-VESGGGLVQPGRSLRLSCAAS GFTFNDYA--MH WVRQAPGKGLEWVS GIS--WDSSSIGYADSVKG RFTISRDNAKNSLYLQMNSLRAEDMALYYCVK GRDYYDSGGYFTVAF-------DI WGQGTMVTVSS 1dvf_d1.3 QVQL-QESGPGLVAPSQSLSITCTVS GFSLTGYG--VN WVRQPPGKGLEWLG MIW---GDGNTDYNSALKS RLSISKDNSKSQVFLKMNSLHTDDTARYYCAR ERDYRL----------------DY WGQGTTLTVSS 1dvf_e5.2 QVQL-QQSGTELVKSGASVKLSCTAS GFNIKDTH--MN WVKQRPEQGLEWIG RID---PANGNIQYDPKFR GKATITADTSSNTAYLQLSLTSEDTAVYYCAT KVIYYQGRGAM-----------DY WGQGTTLTVS- 1eap EVQL-QESGTELVKPGASVKISCKAS GYISTDHA--IH WVKQRPEQGLEWIG YIS--PGNGDIKYNEKFKV KATLTADQSSSTAYMQLNSLTSEDSAVYFCKR SYYGSSYV--------------DY WGQGTTLTVSS 1fai QVQL-QQSGAELVRAGSSVKMSCKAS GYTFTSYG--VN WVKQRPGQGLEWIG YIN--PGKGYLSYNEKFKG KTTLTVDRSSSTAYMQLRSLTSEDAAVYFCAR SFYGGSDLAVYYF---------DS WGQGTTLTVSS 1fbi QVQL-QQPGAELVKPGASVKLSCKAS GYTFTSYW--MH WVKQGPGQGLEWIG EID--PSDSYPNYNEKFKG KATLTVDKSSSTAYMQLSSLTSEDSAVYYCAS LYYYGTSYGVL-----------DY WGQGTSVTVSS 1fdl QVQL-KESGPGLVAPSQSLSITCTVS GFSLTGYG--VN WVRQPPGKGLEWLG MIW---GDGNTDYNSALKS RLSISKDNSKSQVFLKMNSLHTDDTARYYCAR ERDYRL----------------DY WGQGTTLTVSS 1fgv EVQL-VESGGGLVQPGGSLRLSCATS GYTFTEYT--MH WMRQAPGKGLEWVA GIN--PKNGGTSYADSVKG RFTISVDKSKNTLYLQMNSLRAEDTAVYYCAR WRGLDVRYF-------------DV WGQGTLVTVSS 1fig DVQL-QQSGPELEKPGASVKISCKAS GFSLPGHN--IN WIVQRNGKSLEWIG NID--PYYGGTNFNPKFKG KATLTVDKSSSTLYMHLTSLQSEDSAVYYCAR RRDGNYGF--------------TY WGQGTLVTVSA 1flr EVKL-DETGGGLVQPGRPMKLSCVAS GFTFSDYW--MN WVRQSPEKGLEWVA QIRNKPYNYETYYSDSVKG RFTISRDDSS--VYLQMNNLRVEDMGIYYCTG SYYGM-----------------DY WGQGTSVTVSS 1for QGQL-QQSGAELVRPGSSVKISCKAS GYAFSSFW--VN WVKQRPGQGLEWIG QIY--PGDGDNKYNGKFKG KATLTADKSSTTAYMQLYSLTSEDSAVYFCAR SGNYPYAM--------------DY WGQGTSVTVSS 1fpt QVQL-QQSGAELVRPGTSVKVSCKAS GYAFTNYL--IQ WIKQRPGQGLEWIG VIN--PGSGGTDYNANFKG KATLTADKSSSIVYMQLSSLTSDDSAVYFCAR DFYDYDVGF-------------DY WGQGTTLTVSS 1frg EVLL-VESGGDLVKPGGFLKLSCAAS GFTFSSFG--MS WVRHTPDKRLEWVA TIS--NGGGYTYYQDSVKG RFTISRDNAKNTLFLEMTSLKSEDAGLYYCAR RERYDEKGF-------------AY WGRGTLVTVSA 1fvb QVQL-QQSGAELMKPGASVKISCKAT GYTFSSYW--IE WVKQRPGHGLEWIG EIL--PGSGSTNYNEKFKG KATFTADTSSNTAYMQLSSLTSEDSAVYYCAR HYYGSSSF--------------AY WGQGTLVTVSA 1fvc EVQL-VESGGGLVQPGGSLRLSCAAS GFNIKDTY--IH WVRQAPGKGLEWVA RIY--PTNGYTRYADSVKG RFTISADTSKNTAYLQMNSLRAEDTAVYYCSR WGGDGFYAM-------------DY WGQGTLVTVSS 1fvd EVQL-VESGGGLVQPGGSLRLSCAAS GFNIKDTY--IH WVRQAPGKGLEWVA RIY--PTNGYTRYADSVKG RFTISADTSKNTLYLQMNSLRAEDTAVYYCSR WGGDGFYAM-------------DV WGQGTLVTVSS 1fve EVQL-VESGGGLVQPGGSLRLSCAAS GFNIKDTY--IH WVRQAPGKGLEWVA RIY--PTNGYTRYADSVKG RFTISADTSKNTAYLQMNSLRAEDTAVYYCSR WGGDGFYAM-------------DY WGQGTLVTVSS 1fvw EVKV-IESGGGLVQPGGSLKLSCAAS GFDFSRYW--MS WVRQAPGKGLEWIG EIN--PDSSTINYTPSLKD KFIISRDNAKNTLYLQMSKVRSEDTALYYCAR LGGDLHYYAM------------DY WGQGTSVTVSS 1ggb QVQL-QESGPGILQPSQTLSLTCSFS GFSLSTYGMGVS WIRQPSGKGLEWLA HIF---WDGDKRYNPSLKS RLKISKDTSNNQVFLKITSVDTADTATYYCVQ EGY-------------------IY WGQGTSVTVSS 1ggc QVQL-QESGPGILQPSQTLSLTCSFS GFSLSTYGMGVS WIRQPSGKGLEWLA HIF---WDGDKRYNPSLKS RLKISKDTSNNQVFLKITSVDTADTATYYCVQ EGY-------------------IY WGQGTSVTVSS 1ggi QVQL-KESGPGILQPSQTLSLTCSFS GFSLSTYGMGVS WIRQPSGKGLEWLA HIF---WDGDKRYNPSLKS RLKISKDTSNNQVFLKITSVDTADTATYYCVQ EGY-------------------IY WGQGTSVTVSS 1ghf -VQL-QQSGPELKKPGETVKISCKLW YTFTDYG---MN WVKQAPGKGLKWMG WIQ--TNTEEPTYGAEFKG RFAFSLETSAFTAYKQINNLKNEDMATYFCAR VEAGF-----------------DY WAQGTTLTVSS 1gig QVQL-KESGPGLVAPSQSLSITCTVS GFLLISNG--VH WVRQPPGKGLEWLG VIW---AGGNTNYNSALMS RVSISKDNSKSQVFLKMKSLQTDDTAMYYCAR DFYDYDVFYYAM----------DY WGQGTSVTVSS 1hcv -VQL-QESGGGLVQAGGSLRLSCAAS GRTGSTYD--MG WFRQAPGKERESVA AIN--WDSARTYYASSVRG RFTISRDNAKKTVYLQMNSLKPEDTAVYTCGA GEGGTW----------------DS WGQGTQVTVSS 1hfm DVQL-QESGPSLVKPSQTLSLTCSVT GDSITSDY--WS WIRKFPGNRLEYMG YVS---YSGSTYYNPSLKS RISITRDTSKNQYYLDLNSVTTEDTATYYCAN WDG-------------------DY WGQGTLVTVSA 1hil EVQL-VESGGDLVKPGGSLKLSCAAS GFSFSSYG--MS WVRQTPDKRLEWVA TIS--NGGGYTYYPDSVKG RFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR RERYDENGF-------------AY WGQGTLVTVSA 1him EVQL-VESGGDLVKPGGSLKLSCAAS GFSFSSYG--MS WVRQTPDKRLEWVA TIS--NGGGYTYYPDSVKG RFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR RERYDENGF-------------AY WGQGTLVTVSA 1hin EVQL-VESGGDLVKPGGSLKLSCAAS GFSFSSYG--MS WVRQTPDKRLEWVA TIS--NGGGYTYYPDSVKG RFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR RERYDENGF-------------AY WGQGTLVTVSA 1hkl QVQL-QQSGAELVKPGASVKLSCTAS GFNIKDTY--MH WVKQRPKQGLEWIG RID--PANVDTKYDPKFQD KATITADTSSKTTYLQLSSLTSEDTAVYYCAS YYG-------------------IY WGQGTTLTVSS 1hyx EVKL-LESGGGLVKPGGSLKLSCAAS GFTFSNYA--MS WVRQTPEKRLEWVV SIS---SGGSIYYLDSVKG RFTVSRDNARNILYLQMTSLRSEDTAMYFCAR VSHYDGSRDWYF----------DV WGAGTSVTVSS 1hyy EVKL-LESGGGLVKPGGSLKLSCAAS GFTFSNYA--MS WVRQTPEKRLEWVV SIS---SGGSIYYLDSVKG RFTVSRDNARNILYLQMTSLRSEDTAMYFCAR VSHYDGSRDWYF----------DV WGAGTSVTVSS 1iai_409.5.3 EVKL-QESGGGLVQPGGSMKLSCVAS GFTFNNYW--MS WVRQSPEKGLEWVA EIRLNSDNFATHYAESVKG KFIISRDDSKSRLYLQMNSLRAEDTGIYYCVL RPLFYYAV--------------DY WGQGTSVTVSS 1iai_730.1.4 EIQL-VQSGPELKKPGETVKISCKAS GYTFTNYG--MN WVKQAPGKGLKWMA WIN--TYTGEPTYADDFKG RFAFSLETSASTAYLQINNLKNEDTATYFCAR DGYYENYYAM------------DY WGQGTSVTVSS 1ibg -VHL-VQSGPGLVAPSQSLSITCTVS GFSLTTYG--VH WFRQPPGKGLEWLG LIW---AGGNTDYNSALMS RLSINKDNSKSQVFLKMNSLQADDTAMYYCAR FRFASYYDYAV-----------DY WGQGTSVTVSS 1ifh EVQL-VESGGDLVKPGGSLKLSCAAS GFSFSSYG--MS WVRQTPDKRLEWVA TIS--NGGGYTYYPDSVKG RFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR RERYDENGF-------------AY WGQGTLVTVSA 1igc DVQL-VESGGGLVQPGGSRKLSCAAS GFTFSSFG--MH WVRQAPEKGLEWVA YIS--SGSSTLHYADTVKG RFTISRDNPKNTLFLQMTSLRSEDTGMYYCAR WGNYPYYAM-------------DY WGQGTSVTVSS 1igf EVQL-VESGGDLVKPGGSLKLSCAAS GFTFSRCA--MS WVRQTPEKRLEWVA GIS--SGGSYTFYPDTVKG RFIISRNNARNTLSLQMSSLRSEDTAIYYCTR YSSDPFYF--------------DY WGQGTTLTVSS 1igi -VQL-QQSGPELVKPGASVRMSCKSS GYIFTDFY--MN WVRQSHGKSLDYIG YIS--PYSGVTGYNQKFKG KATLTVDKSSSTAYMELRSLTSEDSAVYYCAG SSGNKWAM--------------DY WGHGASVTVSS 1igj -VQL-QQSGPELVKPGASVRMSCKSS GYIFTDFY--MN WVRQSHGKSLDYIG YIS--PYSGVTGYNQKFKG KATLTVDKSSSTAYMELRSLTSEDSAVYYCAG SSGNKWAM--------------DY WGHGASVTVSS 1igm EVHL-LESGGNLVQPGGSLRLSCAAS GFTFNIFV--MS WVRQAPGKGLEWVS GVF--GSGGNTDYADAVKG RFTITRDNSKNTLYLQMNSLRAEDTAIYYCAK HRVSYVLTGF------------DS WGQGTLVTVSS 1igt EVKL-QESGGGLVQPGGSLKLSCATS GFTFSDYY--MY WVRQTPEKRLEWVA YIS--NGGGSTYYPDTVKG RFTISRDNAKNTLYLQMSRLKSEDTAMYYCAR HGGYYAM---------------DY WGQGTTVTVSS 1iif QDQL-QQSGAELVRPGASVKLSCKAL GYIFTDYE--IH WVKQTPVHGLEWIG GIH--PGSSGTAYNQKFKG KATLTADKSSTTAFMELSSLTSEDSAVYYCTR K---------------------DY WGQGTTVTVSS 1ikf EVKL-VESGGGLVQPGGSLKLSCATS GFTFSDYY--MY WVRQNSEKRLEWVA FIS--NGGGSAFYADIVKG RFTISRDNAKNTLYLQMSRLKSEDTAMYYCTR HTLYDTLYGNYPVWF-------AD WGQGTLVTVSA 1ind EVTL-VESGGDSVKPGGSLKLSCAAS GFTLSGET--MS WVRQTPEKRLEWVA TTL--SGGGFTFYSASVKG RFTISRDNAQNNLYLQLNSLRSEDTALYFCAS HRF-------------------VH WGHGTLVTVSA 1ine EVTL-VESGGDSVKPGGSLKLSCAAS GFTLSGET--MS WVRQTPEKRLEWVA TTL--SGGGFTFYSASVKG RFTISRDNAQNNLYLQLNSLRSEDTALYFCAS HRF-------------------VH WGHGTLVTVSA 1jel QVQL-QQSGPELVRPGSSVKISCKGS GYTFTTYA--MH WVKQSHAKSLEWIG LIS--PSSGYTSYNGEFKG KATMTVDKSSSTAYMELARLTSEDSAIYYCAR VMGEQYF---------------DV WGAGTTVTVSS 1jhl QVQL-QQSGAELVRPGASVKLSCKAS GYTFISYW--IN WVKQRPGQGLEWIG NIY--PSDSYTNYNQKFKD KATLTVDKSSSTAYMQLSSPTSEDSAVYYCTR DDNYGAM---------------DY WGQGTTVTV-- 1kel EVKL-VESGGGLGQPGGSLRLSCATS GFTFTDYY--FN WARQPPGKALEWLG FIRNKAKGYTTEYSASVKG RFTISRDNSQGILYLQMNTLRAEDSATYYCAR WGSYAM----------------DY WGQGTSVTVSS 1kem EVKL-VESGGGLGQPGGSLRLSCATS GFTFTDYY--FN WARQPPGKALEWLG FIRNKAKGYTTEYSASVKG RFTISRDNSQGILYLQMNTLRAEDSATYYCAR WGSYAM----------------DY WGQGTSVTVSS 1kip QVQL-QESGPGLVAPSQSLSITCTVS GFSLTGAG--VN WVRQPPGKGLEWLG MIW---GDGNTDYNSALKS RLSISKDNSKSQVFLKMNSLHTDDTARYYCAR ERDYRL----------------DY WGQGTTLTVSS 1kiq QVQL-QESGPGLVAPSQSLSITCTVS GFSLTGYG--VN WVRQPPGKGLEWLG MIW---GDGNTDYNSALKS RLSISKDNSKSQVFLKMNSLHTDDTARYYCAR ERDFRL----------------DY WGQGTTLTVSS 1kir QVQL-QESGPGLVAPSQSLSITCTVS GFSLTGYG--VN WVRQPPGKGLEWLG MIW---GDGNTDYNSALKS RLSISKDNSKSQVFLKMNSLHTDDTARYYCAR ERDYRL----------------DY WGQGTTLTVSS 1lmk -VQL-QQSGTELMKPGRSLKISCKTT GYIFSNYW--IE WVKQRPGHGLEWIG KIL--PGGGSNTYNDKFKG KATFTADTSSNIAYMQLSSLTSEDSAVYYCAR GEDYYAYWYVL-----------DY WGQGTTVTVSS 1mam EVKL-VESGGGLVQPGGSLRLSCATS GFTFTDYY--MS WVRQPPGKALEWLG FIRNKADGYTTEYSASVKG RFTISRDNSQSILYLQMNTLRAEDSATYYCTR DPYGPA----------------AY WGQGTLVTVSA 1mco PLVL-QESGPGLVKPSEALSLTCTVS GDSINTILYYWS WIRQPPGKGLEWIG YIY---YSGSTYGNPSLKS RVTISVNTSKNQFYSKLSSVTAADTAVYYCAR VPLVV-----------------NP WGQGTLVTVSS 1mcp EVKL-VESGGGLVQPGGSLRLSCATS GFTFSDFY--ME WVRQPPGKRLEWIA ASRNKGNKYTTEYSASVKG RFIVSRDTSQSILYLQMNALRAEDTAIYYCAR NYYGSTWYF-------------DV WGAGTTVTVSS 1mel -VQL-QASGGGSVQAGGSLRLSCAAS GYTIGPYC--MG WFRQAPGKEREGVA AIN--MGGGITYYADSVKG RFTISQDNAKNTVYLLMNSLEPEDTAIYYCAA DSTIYASYYECGHGLSTGGYGYDS WGQGTQVTVSS 1mf2 DVQL-VESGGGLVQPGGSRKLSCAAS GFTFMRFG--MH WVRQAPEKGLEWVA YIS--SGSSTIYYADTVKG RFTISRDNPKNTLFLQMTSLRSEDTALYYCAR SGGIERYDGTYYVM--------DY WGQGTSVTVSS 1mfb EVQV-QQSGTVLARPGASVKMSCKAS GYTFTNYW--MH WIKQRPGQGLEWIG AIY--PGNSATFYNHKFRA KTKLTAVTSTITAYMELSSLTNEDSAVYYCTR GGHGYYG---------------DY WGQGASLTVSS 1mfc EVQV-QQSGTVLARPGASVKMSCKAS GYTFTNYW--MH WIKQRPGQGLEWIG AIY--PGNSATFYNHKFRA KTKLTAVTSTITAYMELSSLTNEDSAVYYCTR GGHGYYG---------------DY WGQGASLTVSS 1mfd EVQV-QQSGTVLARPGASVKMSCKAS GYTFTNYW--MH WIKQRPGQGLEWIG AIY--PGNSATFYNHKFRA KTKLTAVTSTITAYMELSSLTNEDSAVYYCTR GGHGYYG---------------DY WGQGASLTVSS 1mfe EVQV-QQSGTVLARPGASVKMSCKAS GYTFTNYW--MH WIKQRPG-GLEWIG AIY--PGNSATFYNHKFRA KTKLTAVTSTITAYMELSSLTNEDSAVYYCTR GGHGYYG---------------DY WGQGASLTVSS 1mig QVQL-VESGPGLVAPSQSLSITCTVS GISLSRYN--VH WVRQSPGKGLEWLG MIW---GGGSIEYNPALKS RLSISKDNSKSQIFLKMNSLQTDDSAMYYCVS YGYGGDRF--------------SY WGQGTLVTVS- 1mim --QL-QQSGTVLARPGASVKMSCKAS GYSFTRYW--MH WIKQRPGQGLEWIG AIY--PGNSDTSYNQKFEG KAKLTAVTSASTAYMELSSLTHEDSAVYYCSR DYGYYF----------------DF WGQGTTLTVSS 1mlb QVQL-QESGAEVMKPGASVKISCKAT GYTFSTYW--IE WVKQRPGHGLEWIG EIL--PGSGSTYYNEKFKG KATFTADTSSNTAYMQLSSLTSEDSAVYYCAR GDGNY-----------------GY WGQGTTLTVSS 1mlc QVQL-QESGAEVMKPGASVKISCKAT GYTFSTYW--IE WVKQRPGHGLEWIG EIL--PGSGSTYYNEKFKG KATFTADTSSNTAYMQLSSLTSEDSAVYYCAR GDGNY-----------------GY WGQGTTLTVSS 1mpa EVNL-QQSGTVLARPGASVRMSCKAS GYSFTSYW--LH WIKQRPGQGLEWIG GIY--PGNRDTRYTQRFKD KAKLTAVTSANTAYMELSSLTNEDSAVYYCSI IYFDYADFIM------------DY WGQGTTVTVS 1mrc QVQL-QQSGAELVKPGASVKLSCKAS GYTFTSYW--MQ WVKQRPGQGLEWIG EI?--???SYTNYNQKFKG KATLTVD???STAYMQLSSLTSEDSAVYYCAN LRGYF-----------------DY WGQGTTLTVSS 1mrd -VQL-QQSGAELVKPGASVKLSCKAS GYTFTSYW--MQ WVKQRPGQGLEWIG EID--PSDSYTNYNQKFKG KATLTVD???STAYMQLSSLTSEDSAVYYCAN LRGYF-----------------DY WGQGTTLTVSS 1mre -VQL-QQSGAELVKPGASVKLSCKAS GYTFTSYW--MQ WVKQRPGQGLEWIG EID--PSDSYTNYNQKFKG KATLTVD???STAYMQLSSLTSEDSAVYYCAN LRGYF-----------------DY WGQGTTLTVSS 1mrf -VQL-QQSGAELVKPGASVKLSCKAS GYTFTSYW--MQ WVKQRPGQGLEWIG EID--PSDSYTNYNQKFKG KATLTVD???STAYMQLSSLTSEDSAVYYCAN LRGYF-----------------DY WGQGTTLTVSS 1nbv EVQP-VETGGGLVQPKGSLKLSCAAS GFSFNTNA--MN WVRQAPGKGLEWVA RIRSKSNNYATYYADSVKD RFTISRDDSQNMLYLQMNNLKTEDTAMYYCVR DQTGTAWF--------------AY WGQGTLVTVSA 1nca QIQL-VQSGPELKKPGETVKISCKAS GYTFTNYG--MN WVKQAPGKGLKWMG WIN--TNTGEPTYGEEFKG RFAFSLETSASTANLQINNLKNEDTATFFCAR GEDNFGSLS-------------DY WGQGTTVTVSS 1ncb QIQL-VQSGPELKKPGETVKISCKAS GYTFTNYG--MN WVKQAPGKGLEWMG WIN--TNTGEPTYGEEFKG RFAFSLETSASTANLQINNLKNEDKATFFCAR GEDNFGSLS-------------DY WGQGTTLTVSS 1ncc QIQL-VQSGPELKKPGETVKISCKAS GYTFTNYG--MN WVKQAPGKGLKWMG WIN--TNTGEPTYGEEFKG RFAFSLETSASTANLQINNLKNEDTATFFCAR GEDNFGSLS-------------DY WGQGTTVTVSS 1ncd QIQL-VQSGPELKKPGETVKISCKAS GYTFTNYG--MN WVKQAPGKGLEWMG WIN--TNTGEPTYGEEFKG RFAFSLETSASTANLQINNLKNEDKATFFCAR GEDNFGSLS-------------DY WGQGTTLTVSS 1ngp QVQL-QQPGAELVKPGASVKLSCKAS GYTFTSYW--MH WVKQRPGRGLEWIG RID--PNSGGTKYNEKFKS KATLTVDKPSSTAYMQLSSLTSEDSAVYYCAR YDYYGSSYFF------------DY WGQGTTLTVS- 1ngq QVQL-QQPGAELVKPGASVKLSCKAS GYTFTSYW--MH WVKQRPGRGLEWIG RID--PNSGGTKYNEKFKS KATLTVDKPSSTAYMQLSSLTSEDSAVYYCAR YDYYGSSYF-------------DY WGQGTTLTVS- 1nld QVKL-QQSGPGLVQPSQSLSITCTVS GFSLTCYG--VH WVRQSPGKGLEWLG VIW---SGGDTDYNAAFIS RLSITKDNSKSQVFFKMNSLQPNDRAIYYCAR RGG-------------------DF WGQGTTVTVSS 1nma EVQL-QQPGAELVKPGASVRMSCKAS GYTFTNYN--MY WVKQSPGQGLEWIG IFY--PGNGDTSYNQKFKD KATLTADKSSNTAYMQLSSLTSEDSAVYYCAR SGGSYRYDGGF-----------DY WGQGTTLTVSS 1nmb QVQL-QQPGAELVKPGASVRMSCKAS GYTFTNYN--MY WVKQSPGQGLEWIG IFY--PGNGDTSYNQKFKD KATLTADKSSNTAYMQLSSLTSEDSAVYYCAR SGGSYRYDGGF-----------DY WGQGTTLTVSS 1nqb -VQL-QQSGAELVKPGASVKLSCKAS GYTFTSYW--MH WVKQRPGRGLEWIG RID--PNSGGTKYNEKFKS KATLTVDKPSSTAYMQLSSLTSEDSAVYYCAR YDYYGSSYF-------------DY WGQGTTVTVSS 1nsn DVQL-QESGPGLVKPSQSLSLTCTVT GYSITSDYA-WN WIRQFPGNKLEWMG YIT---YSGTTSYNPSLKS RISISRDTSKNQFFMQLNSVTTEDTGTFYCTR GN--------------------GD WGQGTTLTVSS 1obe EVQL-VESGGGLVQPGRSLRLSCAAS GFTFNDYA--MH WVRQAPGKGLEWVS GIS--WDSSSIGYADSVKG RFTISRDNAKNSLYLQMNSLRAEDMALYYCVK GRDYYDSGGYFTVAF-------DI WGQGTMVTVSS 1opg EVQL-VQSGGGLVNPGRSLKLSCAAS GFTFSSYG--MS WVRQTPEKRLEWVA AIS--GGGTYIHYPDSVKG RFTISRDNAKNNLYLQMSSLRSEDTALYYCTR HPFYRYDGGNYYAM--------DH WGQGTSVTVSA 1osp EVQL-QESGPSLVKPSQTLSLTCSVT GEPITSGF--WD WIRKFPGNKLEFMG YIR---YGGGTYYNPSLKS PISITRDTSKNHYYLQLNSVVTEDTATYYCAR SRDYYGSSGF------------AF WGEGTLVTVSA 1plg QIQL-QQSGPELVRPGASVKISCKAS GYTFTDYY--IH WVKQRPGEGLEWIG WIY--PGSGNTKYNEKFKG KATLTVDTSSSTAYMQLSSLTSEDSAVYFCAR GGKFAM----------------DY WGQGTSVTVSS 1psk EVQL-QQSGPELVKPGASVKISCKTS GYTFTKYT--MH WVKQSHGKSLEWIG DIN--PNNGGTNYNQKFKG TATLTVHKSSTTAYMELRSLTSEDSAVYYCTS KSF-------------------DY WGQGTTLTVSS 1rmf QVQL-QQSGPELVRPGVSVKISCKGS GYTFIDYA--IH WVKESHAKSLEWIG VIS--AYSGDTNYNQKFKG KATMTVDKSSNTAYLELARLTSEDSAIYYCAR GGWLLLSF--------------DY WGQGTTLTVSS 1tet QIQL-VQSGPELKTPGETVRISCKAS GYTFTTYG--MS WVKQTPGKGFKWMG WIN--TYSGVPTYADDFKG RFAFSLETSASTAYLQINNLKNEDTATYFCAR RSWYF-----------------DV WGTGTTVTVSS 1ucb EVNL-VESGGGLVQPGGSLKVSCVTS GFTFSDYY--MY WVRQTPEKRLEWVA YIS--QGGDITDYPDTVKG RFTISRDNAKNSLYLQMSRLKSEDTAMYYCAR GLDDGAWF--------------AY WGQGTLVTVSV 1vfa QVQL-QESGPGLVAPSQSLSITCTVS GFSLTGYG--VN WVRQPPGKGLEWLG MIW---GDGNTDYNSALKS RLSISKDNSKSQVFLKMNSLHTDDTARYYCAR ERDYRL----------------DY WGQGTTLTVSS 1vfb QVQL-QESGPGLVAPSQSLSITCTVS GFSLTGYG--VN WVRQPPGKGLEWLG MIW---GDGNTDYNSALKS RLSISKDNSKSQVFLKMNSLHTDDTARYYCAR ERDYRL----------------DY WGQGTTLTVSS 1vge QVKLLEQSGAEVKKPGASVKVSCKAS GYSFTSYG--LH WVRQAPGQRLEWMG WIS--AGTGNTKYSQKFRG RVTFTRDTSATTAYMGLSSLRPEDTAVYYCAR DPYGGGKSEF------------DY WGQGTLVTVSS 1vhp EVQL-VESGGGLVQPGGSLRLSCAAS GFTFSSYA--MS WVRQAPGKEREIVS AVS--GSGGSTYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR LKKYAF----------------DY WGQGTLVTVS- 1yec EMQL-QQSGAELLRPGTSVKLSCKTS GYIFTSYW--IH WVKQRSGQGLEWIA RIY--PGTGSTYYNEKFKG KATLTADKSSSTAYMQLSTLKSEDSAVYFCTR WGFIPVREDYVM----------DY WGQGTLVTVSS 1yed AVKL-QQSGPELVRPGTSVKLSCKTS GYIFTSYW--IH WLKQSSGQGLEWIA RIY--PGTGGTYYNEKFKG KATLTADKSSSTAYMQLSSLKSEDSAVYFCTR WGFTTVRENYYAM---------DY WGQGTLVTVSS 1yee EVKL-QESGAELVRPGASVKLSCKTS GYIFTSYW--IH WVKQRAAAGLEWIA RIY--PGTGSSYYNVKFKG KATLTADKSSSTAYMQLSSLKSDDSAVYFCVR WGFIPVREDYVL----------DY WGQGTLVTVSS 1yef EMQL-QQSGAELLRPGTSVKLSCKTS GYIFTSYW--IH WVKQRSGQGLEWIA RIY--PGTGSTYYNEKFKG KATLTADKSSSTAYMQLSTLKSEDSAVYFCTR WGFIPVREDYVM----------DY WGQGTLVTVSS 1yeg EMQL-QQSGAELLRPGTSVKLSCKTS GYIFTSYW--IH WVKQRSGQGLEWIA RIY--PGTGSTYYNEKFKG KATLTADKSSSTAYMQLSTLKSEDSAVYFCTR WGFIPVREDYVM----------DY WGQGTLVTVSS 1yeh EMQL-QQSGAELLRPGTSVKLSCKTS GYIFTSYW--IH WVKQRSGQGLEWIA RIY--PGTGSTYYNEKFKG KATLTADKSSSTAYMQLSTLKSEDSAVYFCTR WGFIPVREDYVM----------DY WGQGTLVTVSS 1yuh QVQF-QQSGAELVKPGASVKLSCKAS GYTFTSYL--MH WIKQRPGRGLEWIG RID--PNNVVTKFNEKFKS KATLTVDKPSSTAYMELSSLTSEDSAVYYCAR YAYCRPM---------------DY WGQGTTVTVS- 2bfv QVQL-QESGGGLVNLGGSMTLSCVAS GFTFNTYY--MS WVRQTPEKTLELVA AIN--SDGEPIYYPDTLKG RVTISRDNAKKTLYLQMSSLNFEDTALYYCAR LNYAVYGM--------------DY WGQGTTVTVSS 2cgr RVQL-LESGAELMKPGASVQISCKAT GYTFSEYW--IE WVKERPGHGLEWIG EIL--PGSGRTNYREKFKG KATFTADTSSNTAYMQLSSLTSEDSAVYYCTR GYSSM-----------------DY WGQGTSVTVSA 2dbl QIQL-VQSGPELKKPGETVKISCKAS GYAFTNYG--VN WVKEAPGKELKWMG WIN--IYTGEPTYVDDFKG RFAFSLETSASTAYLEINNLKNEDTATYFCTR GDYVNWYF--------------DV WGAGTTVTVSS 2f19 QVQL-QQSGAELVRAGSSVKMSCKAS GYTFTSYG--VN WVKQRPGQGLEWIG YIN--PGKGYLSYNEKFKG KTTLTVDRSSSTAYMQLRSLTSEDAAVYFCAR SFYGGSDLAVYYF---------DS WGQGTTLTVSS 2fb4 EVQL-VQSGGGVVQPGRSLRLSCSSS GFIFSSYA--MY WVRQAPGKGLEWVA IIW--DDGSDQHYADSVKG RFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR DGGHGFCSSASCFGP-------DY WGQGTPVTVSS 2fbj EVKL-LESGGGLVQPGGSLKLSCAAS GFDFSKYW--MS WVRQAPGKGLEWIG EIH--PDSGTINYTPSLKD KFIISRDNAKNSLYLQMSKVRSEDTALYYCAR LHYYGYN---------------AY WGQGTLVTVSA 2fgw EVQL-VESGGGLVQPGGSLRLSCATS GYTFTEYT--MH WMRQAPGKGLEWVA GIN--PKNGGTSHNQRFMD RFTISVDKSTSTAYMQMNSLRAEDTAVYYCAR WRRYF-----------------DV WGQGTLVTVSS 2fvb QVQL-QQSGAELMKPGASVKISCKAT GYTFSSYW--IE WVKQRPGHGLEWIG EIL--PGSGSTNYNEKFKG KATFTADTSSNTAYMQLSSLTSEDSAVYYCAR HYYGSSSF--------------AY WGQGTLVTVSA 2fvw EVKV-IESGGGLVQPGGSLKLSCAAS GFDFSRYW--MS WVRQAPGKGLEWIG EIN--PDSSTINYTPSLKD KFIISRDNAKNTLYLQMSKVRSEDTALYYCAR LGGDLHYYAM------------DY WGQGTSVTVSS 2gfb DVKL-VESGGGLVQPGGSRKLSCAAS GFTFSSFG--MH WVRQAPEKGLEWVA YIS--SGSSTIYYADTVKG RFTISRDNPKNTLFLQMTSLRSEDTAMYYCAR GDYYGSRG--------------AY WGQGTLVTVSA 2hfl EVQL-QQSGAELMKPGASVKISCKAS GYTFSDYW--IE WVKQRPGHGLEWIG EIL--PGSGSTNYHERFKG KATFTADTSSSTAYMQLNSLTSEDSGVYYCLH GNYDF-----------------DG WGQGTTLTVSS 2hfm DVQL-QESGPSLVKPSQTLSLTCSVT GDSITSDY--WS WIRKFPGNRLEYMG YVS---YSGSTYYNPSLKS RISITRDTSKNQYYLDLNSVTTEDTATYYCAN WDG-------------------DY WGQGTLVTVSA 2hrp DVQL-VESGGGLVQPGGSRKLSCAAS GFTFMRFG--MH WVRQAPEKGLEWVA YIS--SGSSTIYYADTVKG RFTISRDNPKNTLFLQMTSLRSEDTALYYCAR SGGIERYDGTYYVM--------DY WGQGTSVTVSS 2iff -VQL-QQSGAELMKPGASVKISCKAS GYTFSDYW--IE WVKQRPGHGLEWIG EIL--PGSGSTNYHERFKG KATFTADTSSSTAYMQLNSLTSEDSGVYYCLH GNYDF-----------------DG WGQGTTLTVSS 2ig2 EVQL-VQSGGGVVQPGRSLRLSCSSS GFIFSSYA--MY WVRQAPGKGLEWVA IIW--DDGSDQHYADSVKG RFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR DGGHGFCSSASCFGP-------DY WGQGTPVTVSS 2igf EVQL-VESGGDLVKPGGSLKLSCAAS GFTFSRCA--MS WVRQTPEKRLEWVA GIS--SGGSYTFYPDTVKG RFIISRNNARNTLSLQMSSLRSEDTAIYYCTR YSSDPFYF--------------DY WGQGTTLTVSS 2mcp EVKL-VESGGGLVQPGGSLRLSCATS GFTFSDFY--ME WVRQPPGKRLEWIA ASRNKGNKYTTEYSASVKG RFIVSRDTSQSILYLQMNALRAEDTAIYYCAR NYYGSTWYF-------------DV WGAGTTVTVSS 2psk EVQL-QQSGPELVKPGASVKISCKTS GYTFTKYT--MH WVKQSHGKSLEWIG DIN--PNNGGTNYNQKFKG TATLTVHKSSTTAYMELRSLTSEDSAVYYCTS KSF-------------------DY WGQGTTLTVSS 2rcs QVQL-QQSGAELVKPGASVKLSCTAS GFNIKDTY--MH WVKQRPEQGLEWIG RID--PANGNTKYDPKFQG KATITADTSSNTAYLQLSSLTSEDTAVYYCAS YYG-------------------IY WGQGTTLTVSS 3hfm DVQL-QESGPSLVKPSQTLSLTCSVT GDSITSDY--WS WIRKFPGNRLEYMG YVS---YSGSTYYNPSLKS RISITRDTSKNQYYLDLNSVTTEDTATYYCAN WDG-------------------DY WGQGTLVTVSA 4fab EVKL-DETGGGLVQPGRPMKLSCVAS GFTFSDYW--MN WVRQSPEKGLEWVA QIRNKPYNYETYYSDSVKG RFTISRDDSKSSVYLQMNNLRVEDMGIYYCTG SYYGM-----------------DY WGQGTSVTVSS 6fab EVQL-QQSGVELVRAGSSVKMSCKAS GYTFTSNG--IN WVKQRPGQGLEWIG YNN--PGNGYIAYNEKFKG KTTLTVDKSSSTAYMQLRSLTSEDSAVYFCAR SEYYGGSYKF------------DY WGQGTTLTVSS 7fab AVQL-EQSGPGLVRPSQTLSLTCTVS GTSFDDYY--WT WVRQPPGRGLEWIG YVF---YTGTTLLDPSLRG RVTMLVNTSKNQFSLRLSSVTAADTAVYYCAR NLIAGGI---------------DV WGQGSLVTVSS 8fab AVKL-VQAGGGVVQPGRSLRLSCIAS GFTFSNYG--MH WVRQAPGKGLEWVA VIW--YNGSRTYYGDSVKG RFTISRDNSKRTLYMQMNSLRTEDTAVYYCAR DPDILTAFSF------------DY WGQGVLVTVSS * Consensus: vql- sg l! pg s!$!sC !s G#%f% wv$q pg$ lew!! i g y k! $ !% d s %!y sl eD%a yyC dy WGqGt vtVss ~ - Acidic. ! - Hydrophobic. @ - Amido. # - Aromatic. $ - Basic. % - Hydroxyl containing. ^ - Proline. & - Sulphur containing. * Note: 1VGE is the only antibody (PDB or Kabat) to have an insertion at H4A