Antibodies
Links
This is a brief list of other sites with data and/or software relating to antibodies. For a more extensive list see Kevin Shreder's Antibody Resource.
- Kabat Sequence Database George Johnson and Tai Te Wu's interface to the Kabat Sequence Data. Since they maintain the database, the data is likely to be more up to date than Kabatman and covers other sequences of immunological interest in addition to antibodies. However, the interface is geared towards searching for data on individual antibodies rather than KabatMan's more general approach. Access to the data requires registration for which you need to pay. The raw data from 2000 are available by FTP in the US and mirrored in the UK.
- IMGT Database Marie-Paule LeFranc's Immunogenetics database at the EBI. This is a database of nucleic acid sequence information on immunoglobulins, T-cell receptors and MHC/HLA. There are two interfaces, either via SRS, or their own hierachical retrieval system. You can also obtain the raw data file. Currently (10Sep96) there are 18265 entries, of which 7662 are extensively annotated. The raw datafile is available by FTP or you may access the search software in France.
- VBase Ian Tomlinson's database of human V region gene sequences.
- ABG Juan Carlos Almagro's database of mouse V region gene sequences.
- VBASE2 Ida Retter and Werner Mueller's database of human and mouse immunoglobulin loci extracted from EMBL and Ensembl.
- ABG: Directory of 3D structures of antibodies A directory of information on 3D structures of antibodies publicly available in the PDB from Juan Carlos Almagro at the Instituto de Biotecnologia, UNAM in Mexico.
- Subim: Sophie Deret's software for analysing the Kabat database and determining the variability subgroup for a novel immunoglobulin sequence. The software is not accessible over the Web, but is available by FTP and is described in the paper: Deret, S. et al. (1995), CABIOS 11, 435-439. The program can be downloaded from ftp://ftp.lmcp.jussieu.fr/pub/software/protein/subim/, but with Sophie's permission, a web version is now accessible from our sequence pages
- The Antibody Resource Page Kevin Shreder's page of links to antibody-related Web pages. This is a really extensive list of links with lots of information for those involved with the wet biochemistry of antibodies as well as sequence and structural analysis and modelling.
- The Recombinant Antibody Page Stefan Duebel's introduction to recombinant antibodies including some nice diagrams and useful links.
- Humanization bY Design José Saldanha's page about antibody humanization. An excellent introduction with a detailed discussion of the science behind humanizing and links to useful programs to aid in the process. Also has a page of information on humanized antibodies and search facilities.
- Monoclonal antibodies with clinical indications IMGT's list of antibodies in the clinic and in clinical trials.
- MSRS Antibody Database A subscription database of over 125,000 primary antibodies from over 600 sources all over the wold. Also included is a company database of over 5000 companies who supply to the biotech field.
- Biocompare search tool Allows you to search for commercially available antibodies with a given specificity.
- Molecular Immunology An in-depth description of molecular immunology with explanations and links to other immunology sites.
- AAAAA Annemarie Honegger's antibody page. Lots of useful information, pictures, sequence and structure data and information on antibody modelling.
- WAM Web Antibody Modelling - A page from Tony Rees's group from his time at Bath University that allows you to model an antibody. This is based on the AbM package formally marketted by Oxford Molecular and uses the CAMAL algorithm developed by me. This is free for non-commercial use (but limited to 5 antibodies per month).
- Covance - Covance is a commercial provider of antibody products and custom antibodies
- antibodies-online.com - A German commercial provider of antibodies
- Mike Clark's pages - Includes pages on structure/function relationships in antibodies and the story of the CAMPATH-1 humanization.
- HaptenDB A database of haptens, carrier proteins and anti-hapten antibodies. (Mirror site).
