IMMUNOGLOBULIN 2E8 FAB FRAGMENT ? KAPPA IGG1 MUS MUSCULUS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 DYYIH 17 WIDPEIGDTEYVPKFQG 11 GHDYDRGRFPY crystal 1.90A 22.10% FAB 14-MAR-98 19980314 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 5C8, FREE FAB ? ? IGG MUS MUSCULUS 12 TASSSVSSSNLH 7 STSNLAS 9 HQYHRSPYT 5 DTYMH 17 QIDPANGNTKYDPKFQG 10 DPPYYGHGDY crystal 2.50A 19.00% FAB 18-MAR-98 19980318 CATALYTIC ANTIBODY 29G11 : PHENYL [1-(1-N-SUCCINYLAMINO)PENTYL]PHOSPHONATE HAPTEN ? ? MUS MUSCULUS 11 KASQDIKKYIG 7 YTSTLLP 8 LQYYNLRT 5 DHVIH 17 YISPGNGDIKYNEKFKG 10 GYYGRSNVDY crystal 2.30A 20.30% FAB 05-DEC-97 19971205 COMPLEX (ANTIBODY/ANTIGEN) COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE MOLECULE: NEURAMINIDASE; FRAGMENT: RESIDUES 82 - 468; EC: 3.2.1.18; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSNLHS 9 QQDFTLPFT 5 NYNMY 17 IFYPGNGDTSYNQKFKD 13 SGGSYRYDGGFDY crystal 2.50A 20.00% FV 21-DEC-97 19971221 COMPLEX (IMMUNOGLOBULIN/HYDROLASE) HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.50A 20.30% FV 13-JAN-98 19980113 IMMUNOGLOBULIN CATALYSIS OF A DISFAVORED REACTION: AN ANTIBODY EXO DIELS- ALDERASE-TSA-INHIBITOR COMPLEX AT 1.95 A RESOLUTION AT 1.95 A RESOLUTION ? ? MUS MUSCULUS 16 RSSKSLLNSNGIIHMY 7 QMSKLAS 9 AQNLELPYT 5 NYWLG 17 DIYPGGVYTTNNEKFRG 10 AGGYYTGGDY crystal 1.95A 0.00% FAB 22-JAN-98 19980122 VIRAL PROTEIN/IMMUNE SYSTEM FAB FRAGMENT (ANTIBODY 8F5) COMPLEXED WITH PEPTIDE FROM HUMAN RHINOVIRUS (SEROTYPE 2) VIRAL CAPSID PROTEIN VP2 (RESIDUES 156-170) MOLECULE: HUMAN RHINOVIRUS CAPSID PROTEIN VP2; FRAGMENT: RESIDUES 156 - 170 ? IGG2 MUS MUSCULUS 17 KSSQSLLNSRTQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DIYIH 17 RLDPANGYTKYDPKFQG 9 YYSYYDMDY crystal 2.10A 17.10% FAB 23-JAN-98 19980123 IMMUNOGLOBULIN DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPPT 5 NYGMN 17 WINTYTGEPTYADDFKG 10 AERLRRTFDY crystal 2.10A 22.90% FAB 30-JAN-98 19980130 IMMUNOGLOBULIN DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE ? ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 9 SQVTHVPPT 5 NYGMN 17 WINTYTGEPTYADDFKG 10 AERLRRTFDY crystal 2.40A 21.10% FAB 30-JAN-98 19980130 IMMUNOGLOBULIN FAB FRAGMENT OF A MONOCLONAL ANTI-E-SELECTIN ANTIBODY ? ? ? MUS MUSCULUS 17 KSSQSLLNSGAQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DAYMH 17 RIDSGSSNTNYDPTFKG 11 VGLSYWYAMDY crystal 2.80A 19.50% FAB 16-FEB-98 19980216 IMMUNOGLOBULIN FAB FRAGMENT OF MAB1-IA MONOCLONAL ANTIBODY TO HUMAN RHINOVIRUS 14 NIM-IA SITE ? ? IGG1 MUS MUSCULUS 10 SPSSSVSYMQ 7 STSNLAS 9 QQYSSHPLT 5 TYYMH 17 RVDPDNGGTSFNQKFKG 8 RDDYYFDF crystal 2.70A 16.90% FAB 03-MAR-98 19980303 IMMUNOGLOBULIN B1-8 FV FRAGMENT ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.10A 19.20% FV 03-MAR-98 19980303 IMMUNOGLOBULIN B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-3-NITROPHENYL) ACETATE COMPOUND A (4-HYDROXY-3-NITROPHENYL) ACETATE COMPOUND ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 1.80A 29.60% FV 03-MAR-98 19980303 IMMUNOGLOBULIN B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-5-IODO-3- NITROPHENYL) ACETATE COMPOUND A (4-HYDROXY-5-IODO-3- NITROPHENYL) ACETATE COMPOUND ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.00A 17.10% FV 03-MAR-98 19980303 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) VARIANT FOR CHAIN L GLU81->ASP AND CHAIN H LEU312->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 15.50% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) R96L DELETION MUTANT ON VARIANT FOR CHAIN L GLU81->ASP AND CHAIN H LEU312->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 8 QHFWSTPT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.00A 16.70% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) ENGINEERED MUTANT PRO95L->SER ON VARIANT CHAIN L GLU81- >ASP AND CHAIN H LEU312->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTSRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 17.40% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) HIGH AFFINITY EXPRESSED VARIANT CONTAINING SER26L->GLY, ILE29L->THR, GLU81L->ASP, THR97L->SER, PRO240H->LEU, ASP258H->ALA, LYS281H->GLU, ASN283H->ASP AND LEU312H->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RAGGNTHNYLA 7 YTTTLAA 9 QHFWSTPRS 5 GYGVN 16 MIWGDGNTAYNSALKS 8 ERDYRLDY crystal 2.00A 17.80% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) VARIANT CHAIN L GLU81->ASP ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 17.00% FV 16-MAR-98 19980316 IMMUNOGLOBULIN IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME : LIGHT CHAIN DIMER WITH ASPARTAME LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 22.00% LC-dimer 26-MAR-98 19980326 COMPLEX(ANTIBODY/HIV-1 FRAGMENT) CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV- 1 MOLECULE: HIV-1 GP120 (MN ISOLATE); FRAGMENT: FRAGMENT (RESIDUES 308 - 332); ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 15 RASESVDSYGKSFMH 7 IASNLES 9 QQNNEDPPT 7 RTNYCWH 16 RICYEGSIYYSPSIKS 11 ENHMYETYFDV crystal 3.00A 21.00% FAB 10-FEB-94 19940210 IMMUNOGLOBULIN FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY A5B7 ? ? ? HOMO SAPIENS 10 RASSSVTYIH 7 ATSNLAS 9 QHWSSKPPT 5 DYYMN 19 FIGNKANGYTTEYSASVKG 10 DRGLRFYFDY crystal 2.50A 20.90% FAB 19-FEB-97 19970219 IMMUNOGLOBULIN IGG-FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY CTM01 ? ? IGG HOMO SAPIENS 16 RSSKSLLHSNGDTFLY 7 RMSNLAS 9 MQHLEYPFT 5 DYYIN 17 WIDPGSGNTKYNEKFKG 11 EKTTYYYAMDY crystal 2.80A 23.30% FAB 24-FEB-97 19970224 COMPLEX (IMMUNOGLOBULIN/AUTOANTIGEN) CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC MOLECULE: IGG4 REA FC; FRAGMENT: FC; LAMBDA IGM HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPP 11 QVWDSSSDHAV 5 DYAMH 17 GISWNTGTIIYADSVKG 14 TRSYVVAAEYYFHY crystal 3.15A 22.50% FAB 18-FEB-97 19970218 IMMUNOGLOBULIN IGG-FAB FRAGMENT OF MOUSE MONOCLONAL ANTIBODY CTM01 : EACH OF THE FOUR DOMAINS ADOPT THE IMMUNOGLOBULIN SUPERFAMILY FOLD; ? IGG MUS MUSCULUS 16 RSSKSLLHSNGDTFLY 7 RMSNLAS 9 MQHLEYPFT 5 DYYIN 17 WIDPGSGNTKYNEKFKG 11 EKTTYYYAMDY crystal 3.00A 21.00% FAB 06-MAR-97 19970306 VIRAL PROTEIN/IMMUNE SYSTEM HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 MOLECULE: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 CAPSID PROTEIN; FRAGMENT: AMINO-TERMINAL DOMAIN RESIDUES 1 - 151; SYNONYM: HIV-1 CA, HIV CA, HIV P24, P24; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 AASNLGS 9 QQSKEVPLT 5 SSWIH 17 EIHPNSGNTNYNEKFKG 11 WRYGSPYYFDY crystal 3.70A 21.70% FV 14-MAR-97 19970314 COMPLEX (IMMUNOGLOBULIN/TISSUE FACTOR) A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9) MOLECULE: TISSUE FACTOR; FRAGMENT: EXTRACELLULAR DOMAIN; SYNONYM: TF, THROMBOPLASTIN, COAGULATION FACTOR III; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDIRKYLN 7 YATSLAD 9 LQHGESPYT 5 DYYMH 17 LIDPENGNTIYDPKFQG 8 DNSYYFDY crystal 3.00A 21.70% FAB 10-APR-97 19970410 COMPLEX (ANTIBODY/PEPTIDE) HIV-1 V3 LOOP MIMIC MOLECULE: AIB142; ENGINEERED: YES; OTHER_DETAILS: THE PEPTIDE IS NUMBERED ACCORDING TO THE BH10 ISOLATE KAPPA IGG1 MUS MUSCULUS 15 RASESVDSYGKSFMH 7 IASNLES 9 QQNNEDPPT 7 RTNYCWH 16 RICYEGSIYYSPSIKS 11 ENHMYETYFDV crystal 2.80A 22.00% FAB 06-NOV-96 19961106 IMMUNOGLOBULIN ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A) FAB FROM MOUSE ? ? ? MUS MUSCULUS 12 SVSSSISSSNLH 7 GTSNLAS 9 QQWNSYPYT 5 NYWMS 19 EIRLNSDNFATHYAESVKG 10 RPLFYYAVDY crystal 2.90A 22.00% FAB 14-NOV-94 19941114 IMMUNOGLOBULIN IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY ? ? HOMO SAPIENS 11 RASQEISGYLS 7 AASTLDS 9 LQYASYPRT 5 DTYMH 17 RIDPANGNTKYDPKFQG 5 YYGIY crystal 2.10A 21.70% FAB 15-MAY-97 19970515 IMMUNOGLOBULIN SINGLE CHAIN FV OF C219 : LIGHT AND HEAVY CHAINS LINKED WITH A SYNTHETIC (GGGGS)3 LINKER; ? ? MUS MUSCULUS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDYSYPLT 5 DDFMH 17 RIDPANDNTKYAPKFQD 12 REVYSYYSPLDV crystal 2.36A 20.40% FV 23-JUL-97 19970723 IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF A HUMAN FAB WITH HIGH AFFINITY FOR TETANUS TOXOID ? ? ? HOMO SAPIENS 14 TGSNSNIGAGFTVH 7 ANTNRPS 10 QSYDSSLSAR 5 NYAIH 17 FISYDGSKNYYADSVKG 14 VLFQQLVLYAPFDI crystal 1.84A 0.00% FAB 30-JUL-97 19970730 COMPLEX (OXIDOREDUCTASE/ANTIBODY) STRUCTURE AT 2.7 ANGSTROM RESOLUTION OF THE PARACOCCUS DENITRIFICANS TWO-SUBUNIT CYTOCHROME C OXIDASE COMPLEXED WITH AN ANTIBODY FV FRAGMENT MOLECULE: CYTOCHROME C OXIDASE; SYNONYM: CYTOCHROME AA3, COMPLEX IV, FERROCYTOCHROME C, OXIDOREDUCTASE; EC: 1.9.3.1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLGE 10 QHHYGTPPLT 5 SYTMS 17 SINNGGGRTYYPDTVKG 9 HEYYYAMDY crystal 2.70A 20.70% FV 08-AUG-97 19970808 IMMUNOGLOBULIN DISULFIDE-FREE IMMUNOGLOBULIN FRAGMENT ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; EXPRESSION_SYSTEM: ESCHERICHIA COLI 11 TVQASQDIIKH 7 IYEASNL 11 YCQQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 2.80A 0.00% LC-dimer 08-AUG-97 19970808 CATALYTIC ANTIBODY MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN ? ? ? HOMO SAPIENS 11 KASQDINSYLN 7 RTNRLVD 9 LQYDEFPYT 5 SFWIE 17 EILPGSGGTHYNEKFKG 11 GHSYYFYDGDY crystal 2.60A 20.00% FAB 20-OCT-97 19971020 IMMUNOGLOBULIN IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES ? ? IGG2 MUS MUSCULUS 16 RSSQSLVHSYGNTFLN 7 KVSNRFS 9 SQGTHVPYT 5 RFWMS 19 EIRLKSDNYATHYAESVKG 7 YFYSFSY crystal 2.15A 0.00% FAB 20-OCT-97 19971020 IMMUNOGLOBULIN ANTI TAQ FAB TP7 ? ? ? MUS MUSCULUS 10 SASSSVSYMY 7 DSTNLAS 9 QQWSTYPLT 6 SDYAWN 16 YITYSGTTDYNPSLKS 10 YYYGYWYFDV crystal 2.20A 19.60% FAB 13-NOV-97 19971113 IMMUNE SYSTEM STRUCTURAL COMPARISON OF AMYLOIDOGENIC LIGHT CHAIN DIMER IN TWO CRYSTAL FORMS WITH NONAMYLOIDOGENIC COUNTERPARTS MOLECULE: BENCE-JONES KAPPA I PROTEIN BRE; FRAGMENT: VARIABLE DOMAIN OF LIGHT CHAIN; SYNONYM: BENCE-JONES; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 QASQDISDYLI 7 DASTLET 9 QQYDDLPYT 0 N/A 0 N/A 0 N/A crystal 1.80A 22.60% LC-dimer 13-NOV-98 19981113 IMMUNE SYSTEM COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY ? ? ? 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 2.90A 18.80% FAB 01-DEC-98 19981201 ANTIBODY ENGINEERING COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY ? ? ? HOMO SAPIENS 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 2.90A 19.30% FAB 22-DEC-98 19981222 IMMUNOGLOBULIN BENCE JONES PROTEIN DEL: AN ENTIRE IMMUNOGLOBULIN KAPPA LIGHT-CHAIN DIMER : IMMUNOGLOBULIN LIGHT-CHAIN DIMER KAPPA ? HOMO SAPIENS 11 QASQDISSYLN 7 AASSLET 9 QQYDSLPLT 0 N/A 0 N/A 0 N/A crystal 2.74A 20.70% LC-dimer 13-JAN-99 19990113 IMMUNOGLOBULIN 2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI-DINITROPHENYL- SPIN-LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN ? KAPPA IGG1 10 SASSSVYYMY 7 DTSNLAS 10 QQWSSYPPIT 6 SDYAWN 16 YMSYSGSTRYNPSLRS 6 GWPLAY crystal 2.90A 19.50% FAB 16-JAN-92 19920116 IMMUNOGLOBULIN THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2 ? KAPPA IGG2 17 KSSQSLLNSRTQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DIYIH 17 RLDPANGYTKYDPKFQG 9 YYSYYDMDY crystal 2.80A 19.00% FAB 05-MAY-92 19920505 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF A CHIMERIC FAB' FRAGMENT OF AN ANTIBODY BINDING TUMOUR CELLS ? KAPPA IGG4 11 RASENIYSNLA 7 AATNLAD 9 QHFWGTPYT 5 DHAIH 17 YISPGNDDIKYNEKFKG 5 SYYGH crystal 3.10A 17.60% FAB 30-APR-92 19920430 ANTIBODY ANTIBODY TO CAMPATH-1H HUMANIZED FAB ? ? ? HOMO SAPIENS 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 3.25A 21.40% FAB 18-MAY-98 19980518 ANTIBODY CAMPATH-1G IGG2B RAT MONOCLONAL FAB ? ? IGG2 RATTUS RATTUS 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 2.60A 19.20% FAB 20-MAY-98 19980520 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI ? ? ? MUS MUSCULUS 16 RSSQSLVSNNRRNYLH 7 KVSNRFS 9 SQSSHVPLT 5 TYYMS 17 AINSDGEPIYYPDTLKG 10 LNYAVYGMDY crystal 2.10A 18.70% FV 27-MAY-97 19970527 COMPLEX (POLYMERASE/INHIBITOR) TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB TP7 ? ? MUS MUSCULUS 10 SASSSVSYMY 7 DSTNLAS 9 QQWSTYPLT 5 SDYAW 16 YITYSGTTDYNPSLKS 10 YYYGYWYFDV crystal 2.30A 18.90% FAB 02-JUN-98 19980602 COMPLEX (ANTIBODY/ANTIGEN) VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; FRAGMENT: RECEPTOR BINDING DOMAIN; SYNONYM: VEGF; ENGINEERED: YES ? ? MUS MUSCULUS 11 SASQDISNYLN 7 FTSSLHS 9 QQYSTVPWT 5 NYGMN 17 WINTYTGEPTYAADFKR 14 YPHYYGSSHWYFDV crystal 2.40A 19.60% FAB 30-JUN-98 19980630 BENCE-*JONES PROTEIN LOC (CRYSTALLIZED FROM AMMONIUM SULFATE) ? ? ? HUMAN (HOMO $SAPIENS) 13 SGSSSNIGENSVS 7 EDNSRAS 11 AAWDDSLDVAV 0 N/A 0 N/A 0 N/A crystal 3.00A 19.40% LC-dimer 11-MAR-91 19910311 IMMUNOGLOBULIN LOC NAKS, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN NAKSO4 MOLECULE: LOC - LAMBDA 1 TYPE LIGHT-CHAIN DIMER; SYNONYM: BENCE-JONES PROTEIN; OTHER_DETAILS: CRYSTALLIZED IN NA/K SO4 LAMBDA ? HOMO SAPIENS 13 SGSSSNIGENSVT 7 EDNSRAS 11 AAWDDSLDVAV 0 N/A 0 N/A 0 N/A crystal 2.20A 15.80% LC-dimer 26-MAY-95 19950526 IMMUNE SYSTEM ANTI-P-GLYCOPROTEIN FAB MRK-16 ? ? ? MUS MUSCULUS 16 RSSQSIVHSTGNTYLE 7 KISNRFS 9 FQASHAPRT 5 SYTMS 17 TISSGGGNTYYPDSVKG 10 YYRYEAWFAS crystal 2.80A 20.90% FAB 16-JUL-98 19980716 IMMUNE SYSTEM IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX IMMUNE SYSTEM IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX ? ? MURINE 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPLT 5 SYGMS 17 AISGGGTYIHYPDSVKG 16 HPFYRYDGGNYYAMDH crystal 2.00A 15.20% FAB 15-APR-99 19990415 COMPLEX (ANTIBODY/PEPTIDE) ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-HOMOLOGOUS PEPTIDE MOLECULE: PEPTIDE; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.60A 30.70% FAB 04-AUG-98 19980804 COMPLEX (ANTIBODY/ANTIGEN) STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME MOLECULE: BOBWHITE QUAIL LYSOZYME; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVNYMY 7 DTSKLAS 8 QQWGRNPT 5 DYWIE 17 EILPGSGSTNYHERFKG 7 GNYDFDG crystal 2.60A 19.10% FAB 03-FEB-95 19950203 IMMUNOGLOBULIN IMMUNOGLOBULIN LIGHT CHAIN PROTEIN MOLECULE: BENCE-JONES KAPPA I PROTEIN BRE; SYNONYM: BENCE-JONES; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 QASQDISDYLI 7 DASTLET 9 QQYDDLPYT 0 N/A 0 N/A 0 N/A crystal 2.00A 21.80% LC-dimer 19-JUL-95 19950719 COMPLEX (HUMANIZED ANTIBODY/HYDROLASE) HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME MOLECULE: LYSOZYME; SYNONYM: MURAMIDASE; EC: 3.2.1.17; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.70A 20.80% FV 16-SEP-98 19980916 HUMANIZED ANTIBODY HUMANIZED ANTI-LYSOZYME FV ? ? ? HOMO SAPIENS AND MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.87A 22.00% FV 16-SEP-98 19980916 IMMUNE SYSTEM BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT ? KAPPA ? HOMO SAPIENS 11 TCQASQDIIKY 7 IYEASNL 11 YCQQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 1.70A 18.20% LC-dimer 29-SEP-98 19980929 IMMUNE SYSTEM FAB FRAGMENT FROM MURINE ASCITES ? ? ? MUS MUSCULUS 11 RASQDIGNFLN 7 YTSRLQS 9 QQGKTLPYT 5 NFGMH 17 YISSGGSSINYADTVKG 13 GGTGTRSLYYFDY crystal 2.50A 16.20% FAB 06-NOV-98 19981106 HYDROLASE/IMMUNE SYSTEM COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A MOLECULE: PROTEIN (RNASE A); EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 YIYMG 19 VAAMDSGGGGTLYADSVKG 12 GGYELRDRTYGQ crystal 2.80A 28.20% HC-dimer 03-NOV-98 19981103 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME; ? ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.30A 23.50% FV 15-JUL-99 19990715 IMMUNE SYSTEM INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE ? ? ? MUS MUSCULUS 11 HASQGISSNIG 7 HGTNLED 9 VQYVQFPFT 6 SDYAWN 16 YISYSGSTSYSPSLKS 12 SLTWLLRRKRSY crystal 2.60A 20.50% FAB 20-JUL-99 19990720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN WITH ITS HAPTEN ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 FQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVRAMDY crystal 1.90A 0.00% FAB 22-JUL-99 19990722 IMMUNE SYSTEM DECARBOXYLASE CATALYTIC ANTIBODY 21D8 UNLIGANDED FORM : THE CONSTANT DOMAIN (RESIDUES 103-214) IS FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1- 102) IS FROM MURINE SOURCE; ? ? MUS MUSCULUS + HOMO SAPIENS 11 RTSQEISGYLS 7 DATKLDS 9 LQYASFPRT 5 SYWMH 17 LIDPSNGRTNFNDKFKS 3 IAY crystal 2.10A 18.80% FAB 08-NOV-99 19991108 IMMUNE SYSTEM DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX : THE CONSTANT DOMAIN (RESIDUES 103-214) IS FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1- 102) IS FROM MURINE SOURCE; ? ? MUS MUSCULUS + HOMO SAPIENS 11 RTSQEISGYLS 7 DATKLDS 9 LQYASFPRT 5 SYWMH 17 LIDPSNGRTNFNDKFKS 3 IAY crystal 1.61A 18.80% FAB 09-NOV-99 19991109 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR ? ? ? RATTUS NORVEGICUS 11 QASQDINKYIA 7 YTSILVL 8 LQYGNLYT 5 TNGVS 16 AISSGGSPYYNSALKS 9 EDGWNYFDY crystal 2.40A 19.60% FAB 17-NOV-99 19991117 TRANSFERASE/IMMUNE SYSTEM/DNA CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE- PRIMER MOLECULE: HIV-1 REVERSE TRANSCRIPTASE (CHAIN A); SYNONYM: HIV-1 RT; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: M184I; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.50A 26.20% FAB 03-AUG-99 19990803 IMMUNE SYSTEM/DNA AN AUTOANTIBODY TO SINGLE-STRANDED DNA: COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE-FAB COMPLEX MOLECULE: DNA (5'-D(*TP*TP*T)-3'); ENGINEERED: YES ? ? 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPLT 5 TNAMN 19 RIRSKSNNYATYYADSVKD 10 DQTGTAWFAY crystal 2.66A 19.10% FAB 16-MAR-93 19930316 IMMUNE SYSTEM STRUCTURE OF HUMAN LAMDA-6 LIGHT CHAIN DIMER JTO ? LAMBDA ? ESCHERICHIA COLI 13 TRSSGNIDSNYVQ 7 EDNQRPS 11 YCQSYDARNVV 0 N/A 0 N/A 0 N/A crystal 1.90A 18.40% LC-dimer 05-MAR-99 19990305 ANTIBODY 1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN MOLECULE: PROTEIN (PEPTIDE ANTIGEN); ENGINEERED: YES; OTHER_DETAILS: SYNTHETIC PEPTIDE; ? ? ESCHERICHIA COLI 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 1.90A 22.00% FAB 12-MAR-99 19990312 CATALYTIC ANTIBODY CONVERGENCE OF CATALYTIC ANTIBODY AND TERPENE CYCLASE MECHANISMS: POLYENE CYCLIZATION DIRECTED BY CARBOCATION-PI INTERACTIONS ? ? ? MUS MUSCULUS 12 SASSSVSSNYVY 7 STSNLAS 9 LQWSSFPYT 6 SGYAWN 16 YIRYSGDTRYNPSLKS 7 GYGNSDY crystal 2.70A 16.50% FAB 24-MAR-99 19990324 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-RELATED PEPTIDE MOLECULE: PROTEIN (BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.65A 27.70% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 ? KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.80A 22.10% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED PEPTIDE MOLECULE: PROTEIN (ANTIGEN BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.75A 23.20% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED D-PEPTIDE MOLECULE: PROTEIN (ANTIGEN BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.80A 23.70% FAB 19-MAR-99 19990319 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI ? ? ? MUS MUSCULUS 16 RSSQSLVSNNRRNYLH 7 KVSNRFS 9 SQSSHVPLT 5 TYYMS 17 AINSDGEPIYYPDTLKG 10 LNYAVYGMDY crystal 2.10A 17.80% FV 11-APR-97 19970411 IMMUNOGLOBULIN LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB ATION OF AN ANTI-SWEETENER FAB KAPPA IGG2 16 RPSQSLVHSNGNTYLH 7 RVSNRFS 9 SQGTHVPYT 5 EYWIE 17 EILPGSGRTNYREKFKG 7 GYSSMDY crystal 2.60A 21.80% FAB 06-OCT-93 19931006 IMMUNOGLOBULIN IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225 ; D1.3-E225 ? ? MUS MUSCULUS 11 KASQDVRIAVA 7 WASTRHT 9 QHCGSYPFT 5 NYWMH 17 NIYPGSGDSNYDEKFKS 8 GLAFYFDH crystal 2.50A 0.00% FAB 31-MAR-99 19990331 IMMUNOGLOBULIN ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, UNLIGANDED FORM ? KAPPA ? MUS MUSCULUS 17 KSSQNLLHSITRKNYLA 7 WASTRGS 8 KQSYNLYT 5 TDAMN 19 RIRSKGFNFATYYADSVRD 9 GRDGEAMDY crystal 2.50A 19.20% FAB 26-APR-99 19990426 IMMUNE SYSTEM ANTI HIV1 PROTEASE FAB MOLECULE: PROTEIN (IGG1 ANTIBODY 1696 (CONSTANT HEAVY CHAIN)); FRAGMENT: FAB; SYNONYM: IMMUNOGLOBULIN, IGG1 ? IGG1 MUS MUSCULUS 16 RSSQTIVHNNGNTYLE 7 KVSNRFS 9 FQGSHFPPT 5 DYSMH 17 WINTETDEPTFADDFKG 11 DRHDYGEIFTY crystal 3.00A 18.30% FAB 06-MAY-99 19990506 IMMUNOGLOBULIN ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7 ? ? ? MUS MUSCULUS 10 RASSSVTYIH 7 ATSNLAS 9 QHWSSKPPT 5 DYYMN 19 FIGNKANGYTTEYSASVKG 10 DRGLRFYFDY crystal 2.10A 21.20% FAB 01-MAY-96 19960501 IMMUNOGLOBULIN IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER : COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER; KAPPA IGG1 HOMO SAPIENS 16 RSSQIIVHNNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YISQGGDITDYPDTVKG 10 GLDDGAWFAY crystal 2.50A 23.80% FAB 15-MAR-95 19950315 IMMUNOGLOBULIN IGG FAB (IGG3, KAPPA) FRAGMENT (MBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER : COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER; KAPPA IGG MUS MUSCULUS 16 RSSQIIVHNNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YISQGGDITDYPDTVKG 10 GLDDGAWFAY crystal 2.80A 19.70% FAB 15-MAR-95 19950315 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CH3 DOMAIN FROM THE MAK33 ANTIBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 19.60% FC 06-AUG-99 19990806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLI 7 LVSKRDS 10 WQGTHFPHTV 5 DYYIQ 17 WIDPENGNSEYAPRFQG 5 DLHDY crystal 2.00A 17.10% FAB 14-AUG-99 19990814 IMMUNE SYSTEM CATALYTIC ANTIBODY 7C8 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY 7C8 COMPLEX ? ? MUS MUSCULUS 11 RASQSVSNKLH 7 FASQSIP 9 HQTHGRPLT 5 SSYIN 17 WIYAGSGGTVYNQHFTD 9 YRYDEGFAY crystal 2.20A 21.10% FAB 20-AUG-99 19990820 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE MOLECULE: RECOGNITION PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLI 7 LVSKRDS 10 WQGTHFPHTV 5 DYYIQ 17