IMMUNOGLOBULIN 2E8 FAB FRAGMENT ? KAPPA IGG1 MUS MUSCULUS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 DYYIH 17 WIDPEIGDTEYVPKFQG 11 GHDYDRGRFPY crystal 1.90A 22.10% FAB 14-MAR-98 19980314 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 5C8, FREE FAB ? ? IGG MUS MUSCULUS 12 TASSSVSSSNLH 7 STSNLAS 9 HQYHRSPYT 5 DTYMH 17 QIDPANGNTKYDPKFQG 10 DPPYYGHGDY crystal 2.50A 19.00% FAB 18-MAR-98 19980318 CATALYTIC ANTIBODY 29G11 PHENYL [1- (1-N-SUCCINYLAMINO) PENTYL] PHOSPHONATE HAPTEN ? ? MUS MUSCULUS 11 KASQDIKKYIG 7 YTSTLLP 8 LQYYNLRT 5 DHVIH 17 YISPGNGDIKYNEKFKG 10 GYYGRSNVDY crystal 2.30A 20.30% FAB 05-DEC-97 19971205 COMPLEX (ANTIBODY / ANTIGEN) COMPLEX BETWEEN NC10 ANTI - INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE MOLECULE: NEURAMINIDASE; FRAGMENT: RESIDUES 82 - 468; EC: 3.2.1.18; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSNLHS 9 QQDFTLPFT 5 NYNMY 17 IFYPGNGDTSYNQKFKD 13 SGGSYRYDGGFDY crystal 2.50A 20.00% FV 21-DEC-97 19971221 COMPLEX (IMMUNOGLOBULIN / HYDROLASE) HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.50A 20.30% FV 13-JAN-98 19980113 IMMUNOGLOBULIN CATALYSIS OF A DISFAVORED REACTION: AN ANTIBODY EXO DIELS- ALDERASE-TSA-INHIBITOR COMPLEX AT 1.95 A RESOLUTION EXO DIELS-ALDERASE-TSA-INHIBITOR ? ? MUS MUSCULUS 16 RSSKSLLNSNGIIHMY 7 QMSKLAS 9 AQNLELPYT 5 NYWLG 17 DIYPGGVYTTNNEKFRG 10 AGGYYTGGDY crystal 1.95A 18.80% FAB 22-JAN-98 19980122 VIRAL PROTEIN / IMMUNE SYSTEM FAB FRAGMENT (ANTIBODY 8F5) COMPLEXED WITH PEPTIDE FROM HUMAN RHINOVIRUS (SEROTYPE 2) VIRAL CAPSID PROTEIN VP2 (RESIDUES 156 - 170) MOLECULE: HUMAN RHINOVIRUS CAPSID PROTEIN VP2; FRAGMENT: RESIDUES 156 - 170 ? IGG2 MUS MUSCULUS 17 KSSQSLLNSRTQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DIYIH 17 RLDPANGYTKYDPKFQG 9 YYSYYDMDY crystal 2.10A 17.10% FAB 23-JAN-98 19980123 IMMUNOGLOBULIN DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPPT 5 NYGMN 17 WINTYTGEPTYADDFKG 10 AERLRRTFDY crystal 2.10A 22.90% FAB 30-JAN-98 19980130 IMMUNOGLOBULIN DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE ? ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 9 SQVTHVPPT 5 NYGMN 17 WINTYTGEPTYADDFKG 10 AERLRRTFDY crystal 2.40A 21.10% FAB 30-JAN-98 19980130 IMMUNOGLOBULIN FAB FRAGMENT OF A MONOCLONAL ANTI-E-SELECTIN ANTIBODY ? ? ? MUS MUSCULUS 17 KSSQSLLNSGAQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DAYMH 17 RIDSGSSNTNYDPTFKG 11 VGLSYWYAMDY crystal 2.80A 19.50% FAB 16-FEB-98 19980216 IMMUNOGLOBULIN FAB FRAGMENT OF MAB1 - IA MONOCLONAL ANTIBODY TO HUMAN RHINOVIRUS 14 NIM - IA SITE ? ? IGG1 MUS MUSCULUS 10 SPSSSVSYMQ 7 STSNLAS 9 QQYSSHPLT 5 TYYMH 17 RVDPDNGGTSFNQKFKG 8 RDDYYFDF crystal 2.70A 16.90% FAB 03-MAR-98 19980303 IMMUNOGLOBULIN B1 - 8 FV FRAGMENT ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.10A 19.20% FV 03-MAR-98 19980303 IMMUNE SYSTEM B1 - 8 FV FRAGMENT COMPLEXED WITH A (4 - HYDROXY - 3 - NITROPHENYL) ACETATE COMPOUND A (4 - HYDROXY - 3 - NITROPHENYL) ACETATE COMPOUND ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 1.80A 29.60% FV 03-MAR-98 19980303 IMMUNOGLOBULIN B1 - 8 FV FRAGMENT COMPLEXED WITH A (4 - HYDROXY - 5 - IODO - 3 - NITROPHENYL) ACETATE COMPOUND A (4 - HYDROXY - 5 - IODO - 3 - NITROPHENYL) ACETATE COMPOUND ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.00A 17.10% FV 03-MAR-98 19980303 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB / C, IGG1, K) VARIANT FOR CHAIN L GLU81 ->ASP AND CHAIN H LEU312 ->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 15.50% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB / C, IGG1, K) R96L DELETION MUTANT ON VARIANT FOR CHAIN L GLU81 ->ASP AND CHAIN H LEU312 ->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 8 QHFWSTPT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.00A 16.70% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB / C, IGG1, K) ENGINEERED MUTANT PRO95L ->SER ON VARIANT CHAIN L GLU81 ->ASP AND CHAIN H LEU312 ->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTSRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 17.40% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB / C, IGG1, K) HIGH AFFINITY EXPRESSED VARIANT CONTAINING SER26L ->GLY, ILE29L ->THR, GLU81L ->ASP, THR97L ->SER, PRO240H ->LEU, ASP258H ->ALA, LYS281H ->GLU, ASN283H ->ASP AND LEU312H ->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RAGGNTHNYLA 7 YTTTLAA 9 QHFWSTPRS 5 GYGVN 16 MIWGDGNTAYNSALKS 8 ERDYRLDY crystal 2.00A 17.80% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB / C, IGG1, K) VARIANT CHAIN L GLU81 ->ASP ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 17.00% FV 16-MAR-98 19980316 IMMUNOGLOBULIN IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME LIGHT CHAIN DIMER WITH ASPARTAME LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 22.00% LC-dimer 26-MAR-98 19980326 COMPLEX (ANTIBODY / HIV - 1 FRAGMENT) CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV - 1 MOLECULE: HIV - 1 GP120 (MN ISOLATE); FRAGMENT: FRAGMENT (RESIDUES 308 - 332); ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 15 RASESVDSYGKSFMH 7 IASNLES 9 QQNNEDPPT 7 RTNYCWH 16 RICYEGSIYYSPSIKS 11 ENHMYETYFDV crystal 3.00A 21.00% FAB 10-FEB-94 19940210 IMMUNOGLOBULIN FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY A5B7 ? ? ? HOMO SAPIENS 10 RASSSVTYIH 7 ATSNLAS 9 QHWSSKPPT 5 DYYMN 19 FIGNKANGYTTEYSASVKG 10 DRGLRFYFDY crystal 2.50A 20.90% FAB 19-FEB-97 19970219 IMMUNOGLOBULIN IGG - FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY CTM01 ? ? IGG HOMO SAPIENS 16 RSSKSLLHSNGDTFLY 7 RMSNLAS 9 MQHLEYPFT 5 DYYIN 17 WIDPGSGNTKYNEKFKG 11 EKTTYYYAMDY crystal 2.80A 23.30% FAB 24-FEB-97 19970224 COMPLEX (IMMUNOGLOBULIN / AUTOANTIGEN) CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC MOLECULE: IGG4 REA FC; FRAGMENT: FC; LAMBDA IGM HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPP 11 QVWDSSSDHAV 5 DYAMH 17 GISWNTGTIIYADSVKG 14 TRSYVVAAEYYFHY crystal 3.15A 22.50% FAB 18-FEB-97 19970218 IMMUNOGLOBULIN IGG - FAB FRAGMENT OF MOUSE MONOCLONAL ANTIBODY CTM01 EACH OF THE FOUR DOMAINS ADOPT THE IMMUNOGLOBULIN SUPERFAMILY FOLD; ? IGG MUS MUSCULUS 16 RSSKSLLHSNGDTFLY 7 RMSNLAS 9 MQHLEYPFT 5 DYYIN 17 WIDPGSGNTKYNEKFKG 11 EKTTYYYAMDY crystal 3.00A 21.00% FAB 06-MAR-97 19970306 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 MOLECULE: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 CAPSID PROTEIN; FRAGMENT: AMINO - TERMINAL DOMAIN RESIDUES 1 - 151; SYNONYM: HIV - 1 CA, HIV CA, HIV P24, P24; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 AASNLGS 9 QQSKEVPLT 5 SSWIH 17 EIHPNSGNTNYNEKFKG 11 WRYGSPYYFDY crystal 3.70A 21.70% FV 14-MAR-97 19970314 COMPLEX (IMMUNOGLOBULIN / TISSUE FACTOR) A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9) MOLECULE: TISSUE FACTOR; FRAGMENT: EXTRACELLULAR DOMAIN; SYNONYM: TF, THROMBOPLASTIN, COAGULATION FACTOR III; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDIRKYLN 7 YATSLAD 9 LQHGESPYT 5 DYYMH 17 LIDPENGNTIYDPKFQG 8 DNSYYFDY crystal 3.00A 21.70% FAB 10-APR-97 19970410 COMPLEX (ANTIBODY / PEPTIDE) HIV - 1 V3 LOOP MIMIC MOLECULE: AIB142; ENGINEERED: YES; OTHER_DETAILS: THE PEPTIDE IS NUMBERED ACCORDING TO THE BH10 ISOLATE KAPPA IGG1 MUS MUSCULUS 15 RASESVDSYGKSFMH 7 IASNLES 9 QQNNEDPPT 7 RTNYCWH 16 RICYEGSIYYSPSIKS 11 ENHMYETYFDV crystal 2.80A 22.00% FAB 06-NOV-96 19961106 IMMUNOGLOBULIN ANTI - IDIOTYPIC FAB 409.5.3 (IGG2A) FAB FROM MOUSE ? ? ? MUS MUSCULUS 12 SVSSSISSSNLH 7 GTSNLAS 9 QQWNSYPYT 5 NYWMS 19 EIRLNSDNFATHYAESVKG 10 RPLFYYAVDY crystal 2.90A 22.00% FAB 14-NOV-94 19941114 IMMUNOGLOBULIN IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5 - (PARA - NITROPHENYL PHOSPHONATE) - PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY HAPTEN 5 - (PARA - NITROPHENYL PHOSPHONATE) - PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY ? ? HOMO SAPIENS 11 RASQEISGYLS 7 AASTLDS 9 LQYASYPRT 5 DTYMH 17 RIDPANGNTKYDPKFQG 5 YYGIY crystal 2.10A 21.70% FAB 15-MAY-97 19970515 IMMUNOGLOBULIN SINGLE CHAIN FV OF C219 LIGHT AND HEAVY CHAINS LINKED WITH A SYNTHETIC (GGGGS) 3 LINKER; ? ? MUS MUSCULUS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDYSYPLT 5 DDFMH 17 RIDPANDNTKYAPKFQD 12 REVYSYYSPLDV crystal 2.36A 20.40% FV 23-JUL-97 19970723 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF A HUMAN FAB WITH HIGH AFFINITY FOR TETANUS TOXOID ? ? ? HOMO SAPIENS 14 TGSNSNIGAGFTVH 7 ANTNRPS 10 QSYDSSLSAR 5 NYAIH 17 FISYDGSKNYYADSVKG 14 VLFQQLVLYAPFDI crystal 1.84A 18.50% FAB 30-JUL-97 19970730 COMPLEX (OXIDOREDUCTASE / ANTIBODY) STRUCTURE AT 2.7 ANGSTROM RESOLUTION OF THE PARACOCCUS DENITRIFICANS TWO - SUBUNIT CYTOCHROME C OXIDASE COMPLEXED WITH AN ANTIBODY FV FRAGMENT MOLECULE: CYTOCHROME C OXIDASE; SYNONYM: CYTOCHROME AA3, COMPLEX IV, FERROCYTOCHROME C, OXIDOREDUCTASE; EC: 1.9.3.1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLGE 10 QHHYGTPPLT 5 SYTMS 17 SINNGGGRTYYPDTVKG 9 HEYYYAMDY crystal 2.70A 20.70% FV 08-AUG-97 19970808 IMMUNOGLOBULIN DISULFIDE - FREE IMMUNOGLOBULIN FRAGMENT ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 11 TVQASQDIIKH 7 IYEASNL 11 YCQQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 2.80A 28.00% LC-dimer 08-AUG-97 19970808 CATALYTIC ANTIBODY MATURE OXY - COPE CATALYTIC ANTIBODY WITH HAPTEN ? ? ? HOMO SAPIENS 11 KASQDINSYLN 7 RTNRLVD 9 LQYDEFPYT 5 SFWIE 17 EILPGSGGTHYNEKFKG 11 GHSYYFYDGDY crystal 2.60A 20.00% FAB 20-OCT-97 19971020 IMMUNOGLOBULIN IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES ? ? IGG2 MUS MUSCULUS 16 RSSQSLVHSYGNTFLN 7 KVSNRFS 9 SQGTHVPYT 5 RFWMS 19 EIRLKSDNYATHYAESVKG 7 YFYSFSY crystal 2.15A 21.40% FAB 20-OCT-97 19971020 IMMUNOGLOBULIN ANTI TAQ FAB TP7 ? ? ? MUS MUSCULUS 10 SASSSVSYMY 7 DSTNLAS 9 QQWSTYPLT 6 SDYAWN 16 YITYSGTTDYNPSLKS 10 YYYGYWYFDV crystal 2.20A 19.60% FAB 13-NOV-97 19971113 IMMUNE SYSTEM STRUCTURAL COMPARISON OF AMYLOIDOGENIC LIGHT CHAIN DIMER IN TWO CRYSTAL FORMS WITH NONAMYLOIDOGENIC COUNTERPARTS MOLECULE: BENCE - JONES KAPPA I PROTEIN BRE; FRAGMENT: VARIABLE DOMAIN OF LIGHT CHAIN; SYNONYM: BENCE - JONES; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 QASQDISDYLI 7 DASTLET 9 QQYDDLPYT 0 N/A 0 N/A 0 N/A crystal 1.80A 22.60% LC-dimer 13-NOV-98 19981113 IMMUNE SYSTEM COMPARISON OF THE THREE - DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI - GAMMA - INTERFERON ANTIBODY ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 2.90A 18.80% FAB 01-DEC-98 19981201 ANTIBODY ENGINEERING COMPARISON OF THE THREE - DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI - GAMMA - INTERFERON ANTIBODY ? ? ? HOMO SAPIENS 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 2.90A 19.30% FAB 22-DEC-98 19981222 IMMUNOGLOBULIN BENCE JONES PROTEIN DEL: AN ENTIRE IMMUNOGLOBULIN KAPPA LIGHT - CHAIN DIMER IMMUNOGLOBULIN LIGHT - CHAIN DIMER KAPPA ? HOMO SAPIENS 11 QASQDISSYLN 7 AASSLET 9 QQYDSLPLT 0 N/A 0 N/A 0 N/A crystal 2.74A 20.70% LC-dimer 13-JAN-99 19990113 IMMUNE SYSTEM 2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI - DINITROPHENYL - SPIN - LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN ? KAPPA IGG1 MUS MUSCULUS 10 SASSSVYYMY 7 DTSNLAS 10 QQWSSYPPIT 6 SDYAWN 16 YMSYSGSTRYNPSLRS 6 GWPLAY crystal 2.90A 19.50% FAB 16-JAN-92 19920116 IMMUNOGLOBULIN THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2 ? KAPPA IGG2 MUS MUSCULUS 17 KSSQSLLNSRTQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DIYIH 17 RLDPANGYTKYDPKFQG 9 YYSYYDMDY crystal 2.80A 19.00% FAB 05-MAY-92 19920505 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF A CHIMERIC FAB' FRAGMENT OF AN ANTIBODY BINDING TUMOUR CELLS ? KAPPA IGG4 MUS MUSCULUS, HOMO SAPIENS 11 RASENIYSNLA 7 AATNLAD 9 QHFWGTPYT 5 DHAIH 17 YISPGNDDIKYNEKFKG 5 SYYGH crystal 3.10A 17.60% FAB 30-APR-92 19920430 ANTIBODY ANTIBODY TO CAMPATH - 1H HUMANIZED FAB ? ? ? HOMO SAPIENS 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 3.25A 21.40% FAB 18-MAY-98 19980518 ANTIBODY CAMPATH - 1G IGG2B RAT MONOCLONAL FAB ? ? IGG2 RATTUS RATTUS 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 2.60A 19.20% FAB 20-MAY-98 19980520 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI ? ? ? MUS MUSCULUS 16 RSSQSLVSNNRRNYLH 7 KVSNRFS 9 SQSSHVPLT 5 TYYMS 17 AINSDGEPIYYPDTLKG 10 LNYAVYGMDY crystal 2.10A 18.70% FV 27-MAY-97 19970527 COMPLEX (POLYMERASE/INHIBITOR) TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB TP7 ? ? MUS MUSCULUS 10 SASSSVSYMY 7 DSTNLAS 9 QQWSTYPLT 5 SDYAW 16 YITYSGTTDYNPSLKS 10 YYYGYWYFDV crystal 2.30A 18.90% FAB 02-JUN-98 19980602 COMPLEX (ANTIBODY / ANTIGEN) VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; FRAGMENT: RECEPTOR BINDING DOMAIN; SYNONYM: VEGF; ENGINEERED: YES ? ? MUS MUSCULUS 11 SASQDISNYLN 7 FTSSLHS 9 QQYSTVPWT 5 NYGMN 17 WINTYTGEPTYAADFKR 14 YPHYYGSSHWYFDV crystal 2.40A 19.60% FAB 30-JUN-98 19980630 IMMUNOGLOBULIN LOC NAKS, A LAMBDA 1 TYPE LIGHT - CHAIN DIMER (BENCE - JONES PROTEIN) CRYSTALLIZED IN NAKSO4 MOLECULE: LOC - LAMBDA 1 TYPE LIGHT - CHAIN DIMER; SYNONYM: BENCE - JONES PROTEIN; OTHER_DETAILS: CRYSTALLIZED IN NA / K SO4 LAMBDA ? HOMO SAPIENS 13 SGSSSNIGENSVT 7 EDNSRAS 11 AAWDDSLDVAV 0 N/A 0 N/A 0 N/A crystal 2.20A 15.80% LC-dimer 26-MAY-95 19950526 IMMUNE SYSTEM ANTI - P - GLYCOPROTEIN FAB MRK - 16 ? ? ? MUS MUSCULUS 16 RSSQSIVHSTGNTYLE 7 KISNRFS 9 FQASHAPRT 5 SYTMS 17 TISSGGGNTYYPDSVKG 10 YYRYEAWFAS crystal 2.80A 20.90% FAB 16-JUL-98 19980716 IMMUNE SYSTEM IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX IMMUNE SYSTEM IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX ? ? MURINE 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPLT 5 SYGMS 17 AISGGGTYIHYPDSVKG 16 HPFYRYDGGNYYAMDH crystal 2.00A 15.20% FAB 15-APR-99 19990415 COMPLEX (ANTIBODY / PEPTIDE) ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE - HOMOLOGOUS PEPTIDE MOLECULE: PEPTIDE; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.60A 24.60% FAB 04-AUG-98 19980804 ANTIBODY / ANTIGEN STRUCTURE OF AN ANTI - HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME MOLECULE: BOBWHITE QUAIL LYSOZYME; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVNYMY 7 DTSKLAS 8 QQWGRNPT 5 DYWIE 17 EILPGSGSTNYHERFKG 7 GNYDFDG crystal 2.60A 19.10% FAB 03-FEB-95 19950203 IMMUNOGLOBULIN IMMUNOGLOBULIN LIGHT CHAIN PROTEIN MOLECULE: BENCE - JONES KAPPA I PROTEIN BRE; SYNONYM: BENCE - JONES; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 QASQDISDYLI 7 DASTLET 9 QQYDDLPYT 0 N/A 0 N/A 0 N/A crystal 2.00A 21.80% LC-dimer 19-JUL-95 19950719 COMPLEX (HUMANIZED ANTIBODY / HYDROLASE) HUMANIZED ANTI - LYSOZYME FV COMPLEXED WITH LYSOZYME MOLECULE: LYSOZYME; SYNONYM: MURAMIDASE; EC: 3.2.1.17; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.70A 20.80% FV 16-SEP-98 19980916 HUMANIZED ANTIBODY HUMANIZED ANTI - LYSOZYME FV ? ? ? HOMO SAPIENS, MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.87A 22.00% FV 16-SEP-98 19980916 IMMUNE SYSTEM BENCE - JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT ? KAPPA ? HOMO SAPIENS 11 TCQASQDIIKY 7 IYEASNL 11 YCQQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 1.70A 18.20% LC-dimer 29-SEP-98 19980929 IMMUNE SYSTEM FAB FRAGMENT FROM MURINE ASCITES ? ? ? MUS MUSCULUS 11 RASQDIGNFLN 7 YTSRLQS 9 QQGKTLPYT 5 NFGMH 17 YISSGGSSINYADTVKG 13 GGTGTRSLYYFDY crystal 2.50A 16.20% FAB 06-NOV-98 19981106 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A DROMEDARY SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A MOLECULE: PROTEIN (RNASE A); EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 YIYMG 19 VAAMDSGGGGTLYADSVKG 12 GGYELRDRTYGQ crystal 2.80A 22.20% HC-dimer 03-NOV-98 19981103 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME; ? ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.30A 23.50% FV 15-JUL-99 19990715 IMMUNE SYSTEM INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE ? ? ? MUS MUSCULUS 11 HASQGISSNIG 7 HGTNLED 9 VQYVQFPFT 6 SDYAWN 16 YISYSGSTSYSPSLKS 12 SLTWLLRRKRSY crystal 2.60A 20.50% FAB 20-JUL-99 19990720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A DIELS - ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN WITH ITS HAPTEN ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 FQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVRAMDY crystal 1.90A 500.00% FAB 22-JUL-99 19990722 IMMUNE SYSTEM DECARBOXYLASE CATALYTIC ANTIBODY 21D8 UNLIGANDED FORM THE CONSTANT DOMAIN (RESIDUES 103 - 214) IS FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1 - 102) IS FROM MURINE SOURCE; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RTSQEISGYLS 7 DATKLDS 9 LQYASFPRT 5 SYWMH 17 LIDPSNGRTNFNDKFKS 3 IAY crystal 2.10A 18.80% FAB 08-NOV-99 19991108 IMMUNE SYSTEM DECARBOXYLASE CATALYTIC ANTIBODY 21D8 - HAPTEN COMPLEX THE CONSTANT DOMAIN (RESIDUES 103 - 214) IS FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1 - 102) IS FROM MURINE SOURCE; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RTSQEISGYLS 7 DATKLDS 9 LQYASFPRT 5 SYWMH 17 LIDPSNGRTNFNDKFKS 3 IAY crystal 1.61A 18.80% FAB 09-NOV-99 19991109 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR ? ? ? RATTUS NORVEGICUS 11 QASQDINKYIA 7 YTSILVL 8 LQYGNLYT 5 TNGVS 16 AISSGGSPYYNSALKS 9 EDGWNYFDY crystal 2.40A 19.60% FAB 17-NOV-99 19991117 IMMUNE SYSTEM / DNA AN AUTOANTIBODY TO SINGLE - STRANDED DNA: COMPARISON OF THE THREE - DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE - FAB COMPLEX MOLECULE: DNA (5' - D ( *TP *TP *T) - 3'); ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPLT 5 TNAMN 19 RIRSKSNNYATYYADSVKD 10 DQTGTAWFAY crystal 2.66A 19.10% FAB 16-MAR-93 19930316 IMMUNE SYSTEM STRUCTURE OF HUMAN LAMDA - 6 LIGHT CHAIN DIMER JTO ? LAMBDA ? HOMO SAPIENS 13 TRSSGNIDSNYVQ 7 EDNQRPS 11 YCQSYDARNVV 0 N/A 0 N/A 0 N/A crystal 1.90A 18.40% LC-dimer 05-MAR-99 19990305 IMMUNE SYSTEM 1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH - 1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN MOLECULE: PROTEIN (PEPTIDE ANTIGEN); ENGINEERED: YES; OTHER_DETAILS: SYNTHETIC PEPTIDE; ? ? HOMO SAPIENS 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 1.90A 22.00% FAB 12-MAR-99 19990312 CATALYTIC ANTIBODY CONVERGENCE OF CATALYTIC ANTIBODY AND TERPENE CYCLASE MECHANISMS: POLYENE CYCLIZATION DIRECTED BY CARBOCATION - PI INTERACTIONS ? ? ? MUS MUSCULUS 12 SASSSVSSNYVY 7 STSNLAS 9 LQWSSFPYT 6 SGYAWN 16 YIRYSGDTRYNPSLKS 7 GYGNSDY crystal 2.70A 16.50% FAB 24-MAR-99 19990324 POLYSPECIFICITY ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE - RELATED PEPTIDE MOLECULE: PROTEIN (BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.65A 27.70% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 ? KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.80A 22.10% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE - UNRELATED PEPTIDE MOLECULE: PROTEIN (ANTIGEN BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.75A 23.20% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE - UNRELATED D - PEPTIDE MOLECULE: PROTEIN (ANTIGEN BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.80A 23.70% FAB 19-MAR-99 19990319 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI ? ? ? MUS MUSCULUS 16 RSSQSLVSNNRRNYLH 7 KVSNRFS 9 SQSSHVPLT 5 TYYMS 17 AINSDGEPIYYPDTLKG 10 LNYAVYGMDY crystal 2.10A 17.80% FV 11-APR-97 19970411 IMMUNOGLOBULIN LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI - SWEETENER FAB ATION OF AN ANTI - SWEETENER FAB KAPPA IGG2 MUS MUSCULUS 16 RPSQSLVHSNGNTYLH 7 RVSNRFS 9 SQGTHVPYT 5 EYWIE 17 EILPGSGRTNYREKFKG 7 GYSSMDY crystal 2.60A 21.80% FAB 06-OCT-93 19931006 IMMUNOGLOBULIN IDIOTOPE - ANTI - IDIOTOPE FAB - FAB COMPLEX; D1.3 - E225 D1.3 - E225 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 NYWMH 17 NIYPGSGDSNYDEKFKS 8 GLAFYFDH crystal 2.50A 17.90% FAB 31-MAR-99 19990331 IMMUNOGLOBULIN ANTI - ANTI - IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, UNLIGANDED FORM ? KAPPA ? MUS MUSCULUS 17 KSSQNLLHSITRKNYLA 7 WASTRGS 8 KQSYNLYT 5 TDAMN 19 RIRSKGFNFATYYADSVRD 9 GRDGEAMDY crystal 2.50A 19.20% FAB 26-APR-99 19990426 IMMUNE SYSTEM ANTI HIV1 PROTEASE FAB MOLECULE: PROTEIN (IGG1 ANTIBODY 1696 (CONSTANT HEAVY CHAIN) ); FRAGMENT: FAB; SYNONYM: IMMUNOGLOBULIN, IGG1 ? IGG1 MUS MUSCULUS 16 RSSQTIVHNNGNTYLE 7 KVSNRFS 9 FQGSHFPPT 5 DYSMH 17 WINTETDEPTFADDFKG 11 DRHDYGEIFTY crystal 3.00A 18.30% FAB 06-MAY-99 19990506 IMMUNOGLOBULIN ANTI - CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7 ? ? ? MUS MUSCULUS 10 RASSSVTYIH 7 ATSNLAS 9 QHWSSKPPT 5 DYYMN 19 FIGNKANGYTTEYSASVKG 10 DRGLRFYFDY crystal 2.10A 21.20% FAB 01-MAY-96 19960501 IMMUNOGLOBULIN IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER; KAPPA IGG1 HOMO SAPIENS 16 RSSQIIVHNNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YISQGGDITDYPDTVKG 10 GLDDGAWFAY crystal 2.50A 23.80% FAB 15-MAR-95 19950315 IMMUNOGLOBULIN IGG FAB (IGG3, KAPPA) FRAGMENT (MBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER; KAPPA IGG MUS MUSCULUS 16 RSSQIIVHNNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YISQGGDITDYPDTVKG 10 GLDDGAWFAY crystal 2.80A 19.70% FAB 15-MAR-95 19950315 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CH3 DOMAIN FROM THE MAK33 ANTIBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 19.60% FC 06-AUG-99 19990806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - PRION FAB 3F4 ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLI 7 LVSKRDS 10 WQGTHFPHTV 5 DYYIQ 17 WIDPENGNSEYAPRFQG 5 DLHDY crystal 2.00A 17.10% FAB 14-AUG-99 19990814 IMMUNE SYSTEM CATALYTIC ANTIBODY 7C8 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY 7C8 COMPLEX ? ? MUS MUSCULUS 11 RASQSVSNKLH 7 FASQSIP 9 HQTHGRPLT 5 SSYIN 17 WIYAGSGGTVYNQHFTD 9 YRYDEGFAY crystal 2.20A 21.10% FAB 20-AUG-99 19990820 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE MOLECULE: RECOGNITION PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLI 7 LVSKRDS 10 WQGTHFPHTV 5 DYYIQ 17 WIDPENGNSEYAPRFQG 5 DLHDY crystal 2.90A 15.90% FAB 20-AUG-99 19990820 IMMUNE SYSTEM VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; FRAGMENT: RECEPTOR BINDING FRAGMENT; ENGINEERED: YES; ? ? MUS MUSCULUS 11 SASQDISNYLN 7 FTSSLHS 9 QQYSTVPWT 5 HYGMN 17 WINTYTGEPTYAADFKR 14 YPYYYGTSHWYFDV crystal 2.40A 20.80% FAB 01-SEP-99 19990901 IMMUNE SYSTEM UNLIGANDED MATURE OXY - COPE CATALYTIC ANTIBODY ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDINSYLN 7 RTNRLVD 9 LQYDEFPYT 5 SFWIE 17 EILPGSGGTHYNEKFKG 11 GHSYYFYDGDY crystal 2.80A 23.20% FAB 06-OCT-99 19991006 IMMUNE SYSTEM UNLIGANDED GERMLINE PRECURSOR OF AN OXY - COPE CATALYTIC ANTIBODY ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDINSYLS 7 RANRLVD 9 LQYDEFPYT 5 SYWIE 17 EILPGSGSTNYNEKFKG 11 GHSYYFYDGDY crystal 2.00A 21.60% FAB 07-OCT-99 19991007 IMMUNE SYSTEM CONFORMATION EFFECTS IN BIOLOGICAL CATALYSIS INTRODUCED BY OXY - COPE ANTIBODY MATURATION ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDINSYLS 7 RANRLVD 9 LQYDEFPYT 5 SYWIE 17 EILPGSGSTNYNEKFKG 11 GHSYYFYDGDY crystal 2.00A 22.40% FAB 15-OCT-99 19991015 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF AN ANTI - STEROID FAB' AND PROGESTERONE - FAB' COMPLEX IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF AN ANTI - STEROID FAB' AND PROGESTERONE - FAB' COMPLEX KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.80A 20.20% FAB 10-NOV-92 19921110 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF AN ANTI - STEROID FAB' AND PROGESTERONE - FAB' COMPLEX IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF AN ANTI - STEROID FAB' AND PROGESTERONE - FAB' COMPLEX KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.70A 21.00% FAB 11-NOV-92 19921111 IMMUNOGLOBULIN MOLECULAR BASIS OF CROSS - REACTIVITY AND THE LIMITS OF ANTIBODY - ANTIGEN COMPLEMENTARITY ? KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.70A 21.40% FAB 24-AUG-93 19930824 IMMUNOGLOBULIN MOLECULAR BASIS OF CROSS - REACTIVITY AND THE LIMITS OF ANTIBODY - ANTIGEN COMPLEMENTARITY ? KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 3.00A 21.30% FAB 24-AUG-93 19930824 IMMUNOGLOBULIN MOLECULAR BASIS OF CROSS - REACTIVITY AND THE LIMITS OF ANTIBODY - ANTIGEN COMPLEMENTARITY ? KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.70A 21.80% FAB 24-AUG-93 19930824 IMMUNOGLOBULIN MCG, A LAMBDA V TYPE LIGHT - CHAIN DIMER (BENCE - JONES PROTEIN) , CRYSTALLIZED FROM AMMONIUM SULFATE MOLECULE: MCG; SYNONYM: BENCE - JONES PROTEIN; OTHER_DETAILS: A LAMBDA V TYPE LIGHT - CHAIN DIMER LAMBDA ? HOMO SAPIENS 14 TGTSSNVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.30A 14.00% LC-dimer 16-OCT-95 19951016 IMMUNE SYSTEM CRYSTAL STRUCTURE AT 2.7A RESOLUTION OF A COMPLEX BETWEEN A STAPHYLOCOCCUS AUREUS DOMAIN AND A FAB FRAGMENT OF A HUMAN IGM ANTIBODY MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; FRAGMENT: RECOMBINANT DOMAIN D; ENGINEERED: YES ? IGM HOMO SAPIENS 11 RTSQSISSYLN 7 AASSLQS 9 QQSYSAPRT 5 GYGMH 17 LISYDESNKYYADSVKG 12 VKFYDPTAPNDY crystal 2.70A 21.70% FAB 15-NOV-99 19991115 IMMUNOGLOBULIN STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I ? KAPPA IGG1 HOMO SAPIENS 11 RASQSISRWLA 7 KASSLES 7 QQYNSYS 5 DYAMH 17 GISWDSSSIGYADSVKG 17 GRDYYDSGGYFTVAFDI crystal 2.70A 17.70% FAB 27-MAR-92 19920327 IMMUNE SYSTEM THE STRUCTURAL BASIS OF REPERTOIRE SHIFT IN AN IMMUNE RESPONSE TO PHOSPHOCHOLINE COMBINED LIGHT AND HEAVY CHAIN VIA (G4S) 3 LINKER; ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTKHRTP 9 ALWYSNHWV 5 GYGVN 16 MIWGDGSTDYNSALKS 5 DYGPY crystal 2.35A 19.10% FV 08-DEC-99 19991208 IMMUNOGLOBULIN HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FV FRAGMENT FROM AN ANTI - DANSYL SWITCH VARIANT ANTIBODY IGG2A (S) CRYSTALLIZED AT PH 5.25 ? ? IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPFT 5 DAWMD 19 EIRNKANNHATYYAESVKG 10 IYYHYPWFAY crystal 1.45A 18.30% FV 14-JUL-98 19980714 IMMUNE SYSTEM STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ ? KAPPA IGM HOMO SAPIENS 12 GASQSVSSNYLA 7 DASSRAT 9 QQYGSSPLT 5 DYYWS 16 EINHSGSTNYNPSLKS 12 PPHDTSGHYWNY crystal 2.28A 18.00% FAB 15-DEC-99 19991215 IMMUNE SYSTEM FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT - NH2 ? LAMBDA IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 2; SYNTHETIC: YES; OTHER_DETAILS: SELECTED BY PHAGE DISPLAY. 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 19.40% FC 15-DEC-99 19991215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB HGR - 2 F6, A COMPETITIVE ANTAGONIST OF THE GLUCAGON RECEPTOR ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 TTSNLAS 9 QQRSTYPPT 5 SGYWN 16 YISYSGSTYYNPSLKS 14 PPGYYGSGPYAMDY crystal 2.10A 21.70% FAB 04-JAN-00 20000104 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF THE ANTI - LYSOZYME ANTIBODY HYHEL - 63 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.00A 21.70% FAB 04-JAN-00 20000104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN UNLIGANDED (NATIVE) FV FROM A HUMAN IGM ANTI - PEPTIDE ANTIBODY ? ? IGM HOMO SAPIENS 11 RASQDIRNDLG 7 AASSLQS 8 LQQNSNWT 5 SYAMH 17 VISSDGGNKYYTDSVKG 14 GNPPYSSGWGGGDY crystal 2.60A 18.10% FV 04-JAN-00 20000104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - LYSOZYME ANTIBODY ? ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.10A 22.50% FAB 04-JAN-00 20000104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - LYSOZYME ANTIBODY HYHEL - 63 ? ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 1.80A 21.00% FAB 04-JAN-00 20000104 IMMUNOGLOBULIN THE CRYSTAL STRUCTURE OF THE DISULFIDE - STABILIZED FV FRAGMENT OF ANTICANCER ANTIBODY B1: CONFORMATIONAL INFLUENCE OF AN ENGINEERED DISULFIDE BOND ? ? ? MUS MUSCULUS 16 RSSQNLVHSDGKTYLH 7 KVSNRFS 9 SQSTHVPLT 5 DNYMY 17 TISDGGTYIDYSDSVKG 12 SPIYYDYAPFTY crystal 2.00A 18.20% FV 04-MAY-97 19970504 D1.3 BOUND TO ANTI-IDIOTOPIC ANTIBODY E5.2 E5.2 ANTI-IDIOTOPIC ANTIBODY KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.90A 19.40% FV 13-APR-96 19960413 E5.2 ANTI-IDIOTOPIC ANTIBODY BOUND TO D1.3 D1.3 ANTIBODY IDIOTOPE KAPPA IGG1 MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPWT 5 DTHMN 17 RIDPANGNIQYDPKFRG 13 KVIYYQGRGAMDY crystal 1.90A 19.40% FV 13-APR-96 19960413 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PHAGE LIBRARY - DERIVED SINGLE - CHAIN FV FRAGMENT 1F9 IN COMPLEX WITH TURKEY EGG - WHITE LYSOZYME MOLECULE: TURKEY EGG - WHITE LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; EC: 3.2.1.17 ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.00A 22.50% scFv 23-FEB-00 20000223 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT - FC - GAMMA RECEPTOR III COMPLEX ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; CELL: LEUKOCYTE; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_CELLULAR_LOCATION: INCLUSION BODIES; EXPRESSION_SYSTEM_PLASMID: PET21; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; SECRETION: BLOOD; OTHER_DETAILS: OBTAINED BY PLASMIN DIGESTION 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.20A 27.08% FC 07-JUL-00 20000707 IMMUNE SYSTEM CROSSREACTIVE BINDING OF A CIRCULARIZED PEPTIDE TO AN ANTI - TGFALPHA ANTIBODY FAB - FRAGMENT MOLECULE: CYCLIC PEPTIDE; KAPPA ? MUS MUSCULUS 11 RASQDISHYLN 7 YTSTLHS 9 QQGGALPFT 5 NYWMH 17 EILPSNGRTNYNEKFKT 5 SPSDY crystal 1.95A 20.40% FAB 12-JUL-00 20000712 IMMUNE SYSTEM CROSSREACTIVE BINDING OF A CIRCULARIZED PEPTIDE TO AN ANTI - TGFALPHA ANTIBODY FAB - FRAGMENT MOLECULE: CYCLIC PEPTIDE; KAPPA ? MUS MUSCULUS 11 RASQDISHYLN 7 YTSTLHS 9 QQGGALPFT 5 NYWMH 17 EILPSNGRTNYNEKFKT 5 SPSDY crystal 1.90A 24.50% FAB 12-JUL-00 20000712 VIRAL PROTEIN CRYSTAL STRUCTURE OF HIV - 1 CAPSID PROTEIN (P24) IN COMPLEX WITH FAB13B5 MOLECULE: CAPSID PROTEIN P24; FRAGMENT: GAG POLYPROTEIN RESIDUES 143 - 352; SYNONYM: CA; ENGINEERED: YES; OTHER_DETAILS: HIS6 TAG AT N - TERM, PRO1 AND ILE2 DELETED, C - TERMINUS MODIFIED ? ? MUS MUSCULUS 10 SASSSVSYMH 7 EISKLAS 8 QQWNYPFT 5 SYTMH 17 YINPSSGYSNYNQKFKD 11 PVVRLGYNFDY crystal 3.00A 21.00% FAB 18-AUG-00 20000818 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF FAB13B5 AGAINST HIV - 1 CAPSID PROTEIN P24 ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 EISKLAS 8 QQWNYPFT 5 SYTMH 17 YINPSSGYSNYNQKFKD 11 PVVRLGYNFDY crystal 1.80A 22.50% FAB 21-AUG-00 20000821 CATALYTIC ANTIBODY CRYSTAL STRUCTURE OF A CATALYTIC ANTIBODY WITH A SERINE PROTEASE ACTIVE SITE ? KAPPA IGG2 MUS MUSCULUS 11 KASQDIKKYIG 7 YTSTLLP 8 LQYYNLRT 5 DHAIH 17 YISPGNGDIKYNEKFKV 10 SYYGSSYVDY crystal 2.40A 18.60% FAB 10-AUG-94 19940810 IMMUNE SYSTEM M4L / Y (27D) D / T94H MUTANT OF LEN ? KAPPA ? HOMO SAPIENS 17 KSSQSVLDSSNSKNYLA 7 WASTRES 9 QQYYSHPYS 0 N/A 0 N/A 0 N/A crystal 1.50A 21.10% LC-dimer 01-FEB-00 20000201 IMMUNE SYSTEM M4L / Y (27D) D / Q89D / T94H MUTANT OF LEN ? KAPPA ? HOMO SAPIENS 17 KSSQSVLDSSNSKNYLA 7 WASTRES 9 DQYYSHPYS 0 N/A 0 N/A 0 N/A crystal 1.60A 19.40% LC-dimer 03-FEB-00 20000203 IMMUNE SYSTEM Q38D MUTANT OF LEN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PASK40 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 1.60A 23.00% LC-dimer 09-FEB-00 20000209 IMMUNE SYSTEM DOMAIN 4 OF THE BETA COMMON CHAIN IN COMPLEX WITH AN ANTIBODY MOLECULE: CYTOKINE RECEPTOR COMMON BETA CHAIN PRECURSOR; FRAGMENT: DOMAIN 4; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RANESVYSYGDSFMH 7 LASNLAS 9 QQNNEDPWT 5 DYYMK 17 DINPSNGGTLYNQKFKG 10 GDGIHGGFAY crystal 2.80A 22.80% ? 15-FEB-00 20000215 IMMUNE SYSTEM 64M - 2 ANTIBODY FAB COMPLEXED WITH D (5HT) (6 - 4) T MOLECULE: 5' - (D (5HT) P * (6 - 4) T) - 3'; ENGINEERED: YES; OTHER_DETAILS: COMPLEX INVOLVES A C6 - C4 BOND BETWEEN 5HT (1) AND T (2) , A PHOTOPRODUCT LIGAND; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 8 FQGSLVPT 5 SFWMH 17 TIYPGNSDTSYNQKFKG 11 RSGYKYYALDY crystal 2.40A 19.20% FAB 21-FEB-00 20000221 IMMUNE SYSTEM FAB FRAGMENT OF NEUTRALISING MONOCLONAL ANTIBODY 4C4 COMPLEXED WITH G - H LOOP FROM FMDV. MOLECULE: FMDV PEPTIDE; FRAGMENT: G - H LOOP; ENGINEERED: YES ? IGG2 MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQSNEDPLT 5 SYTMS 17 TISSGGAYTYYPDSVKG 11 RAFDSDVGFAS crystal 2.30A 24.80% FAB 03-MAR-00 20000303 IMMUNE SYSTEM KAPPA - 4 IMMUNOGLOBULIN VL, REC ? KAPPA ? HOMO SAPIENS 17 KSSQNLLDSSFDTNTLA 7 WASSRES 9 QQYYSTPPT 0 N/A 0 N/A 0 N/A crystal 1.90A 18.70% LC-dimer 06-MAR-00 20000306 IMMUNE SYSTEM FAB ANTIBODY FRAGMENT OF AN C60 ANTIFULLERENE ANTIBODY ? ? IGG MUS MUSCULUS 11 SASQDISNYLN 7 YTSSLRS 9 QQYSRLPFT 5 SSWMN 17 RIYPGNGNTNYNEKFKG 4 SSAY crystal 2.25A 18.00% FAB 17-MAR-00 20000317 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY MOLECULE: HEMAGGLUTININ (HA2 CHAIN); FRAGMENT: BROMELAIN RELEASED FRAGMENT; OTHER_DETAILS: A RECOMBINANT INFLUENZA STRAIN CONTAINING A / AICHI / 68 (H3N2) HEMAGGLUTININ; ? ? MUS MUSCULUS 10 SASSDISYMH 7 DTSKLAS 8 HQRSSYPT 5 TYFIE 17 EILPGSDNTNFNEKFKD 9 PTGRLWFSY crystal 2.80A 19.60% FAB 22-MAR-00 20000322 IMMUNE SYSTEM THE THREE - DIMENSIONAL STRUCTURE OF AN ANTI - SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAI 7 GTNNRVP 9 ALWYSNHWV 7 TSGMGVG 16 DIWWNDKKYYNPSLKS 16 RTFSYYYGSSFYYFDN crystal 2.60A 19.80% FAB 13-APR-00 20000413 OXIDOREDUCTASE / ELECTRON TRANSPORT STRUCTURE OF THE YEAST CYTOCHROME BC1 COMPLEX CO - CRYSTALLIZED WITH AN ANTIBODY FV - FRAGMENT MOLECULE: UBIQUINOL - CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN 2; FRAGMENT: RESIDUES 17 - 368; EC: 1.10.2.2; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 2.30A 22.20% FV 12-MAY-00 20000512 IMMUNE SYSTEM F124 FAB FRAGMENT FROM A MONOCLONAL ANTI - PRES2 ANTIBODY ? KAPPA ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 VASNLKS 9 QQSNEDPFT 5 DYYMK 17 DINPNNGGTGYNQKFKG 10 DYGSTYGFAY crystal 3.00A 18.40% FAB 18-MAY-00 20000518 IMMUNE SYSTEM STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05 ? ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.10A 0.00% HC-dimer 30-MAY-00 20000530 IMMUNE SYSTEM CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN. WITH ITS AMIDINIUM HAPTEN. ? ? MUS MUSCULUS 16 RSSQSIFHSDGKTYLE 7 KVSKRFS 9 FQGSHVPYT 5 DYNIH 17 YIVPYSGGTTFNQKFKG 6 DYDGVY crystal 1.87A 19.80% FAB 02-JUN-00 20000602 IMMUNE SYSTEM COMPLEX BETWEEN FV ANTIBODY FRAGMENT AND AN ANALOGUE OF THE MAIN IMMUNOGENIC REGION OF THE ACETYLCHOLINE RECEPTOR MOLECULE: ACETYLCHOLINE RECEPTOR ALPHA; FRAGMENT: MAIN IMMUNOGENIC REGION (91 - 100); ENGINEERED: YES; MUTATION: YES; ? ? RATTUS NORVEGICUS 17 TVSGFSLTSFSVSWVRH 7 GYTAYNS 15 YCTRDLYGGYPLGFW 5 SFSVS 16 RMWYDGYTAYNSALKS 26 DLYGGYPLGFWYFDFWGPGTMVTVSS NMR N/A N/A scFv 06-JUN-00 20000606 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI - CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN WITH ANTIGEN ? ? MUS MUSCULUS 14 RSSTGTVTTSNYAN 7 ATNNRAA 9 ALWYSGHWV 5 TYDMS 17 FISSGGGRTSYPDTVKG 8 HFYAVLDY crystal 2.30A 19.70% FAB 10-JUN-00 20000610 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI - CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN WITH ANTIGEN ? ? MUS MUSCULUS 14 RSSTGTVTTSNYAN 7 ATNNRAA 9 ALWYSGHWV 5 TYDMS 17 FISSGGGRTSYPDTVKG 8 HFYAVLDY crystal 2.30A 18.50% ? 10-JUN-00 20000610 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI - CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN WITH ANTIGEN ? ? MUS MUSCULUS 14 RSSTGTVTTSNYAN 7 ATNNRAA 9 ALWYSGHWV 5 TYDMS 17 FISSGGGRTSYPDTVKG 8 HFYAVLDY crystal 2.80A 22.60% ? 10-JUN-00 20000610 VIRAL PROTEIN / IMMUNE SYSTEM IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 24 - RESIDUE PEPTIDE (RESIDUES 308 - 333 OF HIV - 1 GP120 (MN ISOLATE) WITH ALA TO AIB SUBSTITUTION AT POSITION 323 MOLECULE: PROTEIN (EXTERIOR MEMBRANE GLYCOPROTEIN (GP120) ); FRAGMENT: RESIDUES 308 - 332 FROM HIV - 1 GP120; SYNONYM: V3 LOOP; ENGINEERED: YES; MUTATION: YES ? IGG1 MUS MUSCULUS 15 KASQGVDFDGASFMN 7 AASTLES 9 QQSHEDPLT 6 SGYSWH 16 YIHYSAGTNYNPSLKS 17 EEAMPYGNQAYYYAMDC crystal 2.00A 19.60% FAB 21-OCT-98 19981021 IMMUNE SYSTEM STRUCTURE OF THE HUMAN IGE - FC BOUND TO ITS HIGH AFFINITY RECEPTOR FC (EPSILON) RI (ALPHA) ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_COMMON: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PVL1392; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_COMMON: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PVL1392 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.50A 25.40% FC 20-JUN-00 20000620 IMMUNE SYSTEM VARIABLE LIGHT CHAIN DIMER OF ANTI - FERRITIN ANTIBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; ORGAN: SPLEEN; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PETVL 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPFT 0 N/A 0 N/A 0 N/A crystal 2.80A 19.10% LC-dimer 22-JUN-00 20000622 IMMUNE SYSTEM FAB (LNKB - 2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE ? ? ? MUS MUSCULUS 16 ESSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPRT 6 SDYAWN 16 YITYSGSTGYNPSLKS 9 YDDYTWFTY crystal 2.20A 17.10% FAB 05-JUL-00 20000705 IMMUNE SYSTEM FAB FRAGMENT OF MONOCLONAL ANTIBODY (LNKB - 2) AGAINST HUMAN INTERLEUKIN - 2 IN COMPLEX WITH ANTIGENIC PEPTIDE MOLECULE: ANTIGENIC NONAPEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 ESSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPRT 6 SDYAWN 16 YITYSGSTGYNPSLKS 9 YDDYTWFTY crystal 2.60A 16.50% FAB 06-JUL-00 20000706 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI - ARSONATE ANTIBODY ? KAPPA IGG2 MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGSTLPRT 5 SYGVN 17 YINPGKGYLSYNEKFKG 15 SFYGGSDLAVYYFDS crystal 2.70A 18.90% FAB 27-MAY-92 19920527 COMPLEX (ANTIBODY / ANTIGEN) CRYSTAL STRUCTURE OF A CROSS - REACTION COMPLEX BETWEEN FAB F9.13.7 AND GUINEA - FOWL LYSOZYME MOLECULE: GUINEA FOWL LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? IGG1 MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGYTLPYT 5 SYWMH 17 EIDPSDSYPNYNEKFKG 13 LYYYGTSYGVLDY crystal 3.00A 19.00% FAB 19-JAN-95 19950119 IMMUNOGLOBULIN CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF A HUMAN FC FRAGMENT AND ITS COMPLEX WITH FRAGMENT B OF PROTEIN A FROM STAPHYLOCOCCUS AUREUS AT 2.9 - AND 2.8 - ANGSTROMS RESOLUTION ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; TISSUE: SERUM 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.90A 0.00% FC 21-MAY-81 19810521 IMMUNOGLOBULIN CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF A HUMAN FC FRAGMENT AND ITS COMPLEX WITH FRAGMENT B OF PROTEIN A FROM STAPHYLOCOCCUS AUREUS AT 2.9 - AND 2.8 - ANGSTROMS RESOLUTION ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS SUBSP. AUREUS; ORGANISM_TAXID: 93061; STRAIN: NCTC 8325; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 0.00% FC 21-MAY-81 19810521 COMPLEX (ANTIBODY / ANTIGEN) CRYSTAL STRUCTURE OF THE C2 FRAGMENT OF STREPTOCOCCAL PROTEIN G IN COMPLEX WITH THE FC DOMAIN OF HUMAN IGG ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; CELL_LINE: HYBRIDOMA; GENE: N-TERMINAL FRAGMENT OF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PEB2ZHIS GENE: N-TERMINAL FRAGMENT OF; MOL_ID: 2; ORGANISM_SCIENTIFIC: STREPTOCOCCUS; ORGANISM_TAXID: 1301; CELL_LINE: HYBRIDOMA; GENE: N-TERMINAL FRAGMENT OF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PEB2ZHIS GENE: N-TERMINAL FRAGMENT OF 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.20A 28.90% FC 17-JAN-95 19950117 COMPLEX (ANTIBODY - ANTIGEN) CRYSTALLOGRAPHIC REFINEMENT OF THE THREE - DIMENSIONAL STRUCTURE OF THE FAB D1.3 - LYSOZYME COMPLEX AT 2.5 - ANGSTROMS RESOLUTION MOLECULE: HEN EGG WHITE LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.50A 18.40% FAB 27-AUG-90 19900827 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING MOLECULE: VON WILLEBRAND FACTOR; FRAGMENT: COLLAGEN BINDING DOMAIN A3; ENGINEERED: YES; ? IGG MUS MUSCULUS 11 RASQDIGNYLN 7 YTSRLHS 9 QNGGTNPWT 5 TYGVS 16 VIWGDGNTTYHSALIS 7 NYYGMDY crystal 2.03A 22.70% FAB 21-JUL-00 20000721 IMMUNOGLOBULIN MONOCLONAL MURINE ANTIBODY 5G9 - ANTI - HUMAN TISSUE FACTOR ? ? ? MUS MUSCULUS 11 KASQDIRKYLN 7 YATSLAD 9 LQHGESPYT 5 DYYMH 17 LIDPENGNTIYDPKFQG 8 DNSYYFDY crystal 2.50A 21.70% FAB 10-APR-97 19970410 FV FRAGMENT OF A HUMANIZED VERSION OF THE ANTI-CD18 ANTIBODY 'H52' (HUH52-AA FV) ? ? ? SYNTHETIC GENE EXPRESSED IN (ESCHERICHIA COLI) 11 RASQDINNYLN 7 YTSTLES 9 QQGNTLPPT 5 EYTMH 17 GINPKNGGTSYADSVKG 15 WRGLNYGFDVRYFDV crystal 1.90A 18.00% FV 01-NOV-93 19931101 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33 ? ? ? HOMO SAPIENS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPLT 5 SYYMY 17 TISDGGSYTYYPDSVKG 5 DAMDY crystal 2.90A 19.80% FAB 31-JUL-00 20000731 IMMUNOGLOBULIN ROUTES TO CATALYSIS: STRUCTURE OF A CATALYTIC ANTIBODY AND COMPARISON WITH ITS NATURAL COUNTERPART ? KAPPA IGG1 MUS MUSCULUS 12 RASSSVSSTYLH 7 STSNLAS 9 QQYSGYPLT 5 GHNIN 17 NIDPYYGGTNFNPKFKG 10 RRDGNYGFTY crystal 3.00A 22.00% FAB 07-JAN-94 19940107 IMMUNE SYSTEM LYME DISEASE ANTIGEN OSPA IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB LA - 2 MOLECULE: OUTER SURFACE PROTEIN A; SYNONYM: OSPA; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDINKYIA 7 YTSTLQP 9 LQYDNLQRT 5 DYSMY 17 WINTETGEPTYADDFKG 4 GLDS crystal 2.68A 22.60% FAB 07-AUG-00 20000807 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K WITH STILBENE HAPTEN AT 277K ? ? MUS MUSCULUS 16 RSTKSLLHSNGITYLY 7 QMSNLAS 9 AQNLELPPT 5 RYIMS 16 SISSGGITYYPDSVAG 6 GQGRPY crystal 2.45A 23.10% FAB 11-AUG-00 20000811 IMMUNE SYSTEM THE UNLIGANDED GERMLINE PRECURSOR TO THE SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4. ? KAPPA IGG1 HOMO SAPIENS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYMS 19 FIRNKANGYTTEYSASVKG 8 DGSYAMDY crystal 2.10A 22.60% ? 11-AUG-00 20000811 IMMUNE SYSTEM THE HAPTEN COMPLEXED GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4 GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4 ? ? HOMO SAPIENS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYMS 19 FIRNKANGYTTEYSASVKG 8 DGSYAMDY crystal 2.80A 21.60% ? 11-AUG-00 20000811 IMMUNOGLOBULIN 4 - 4 - 20 FAB FRAGMENT ? KAPPA ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLR 7 KVSNRFS 9 SQSTHVPWT 5 DYWMN 19 QIRNKPYNYETYYSDSVKG 7 SYYGMDY crystal 1.85A 18.80% FAB 19-JAN-95 19950119 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB198, AN EFFICIENT PROTECTOR OF ACETYLCHOLINE RECEPTOR AGAINST MYASTHENOGENIC ANTIBODIES ? ? ? RATTUS NORVEGICUS 11 KGSQNINNYLA 7 NTNSLQT 8 YQYNNGYT 5 SFSVS 16 RMWYDGYTAYNSALKS 15 DLYGGYPLGFWYFDF crystal 2.80A 19.80% FAB 21-AUG-00 20000821 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4 MOLECULE: VON WILLEBRAND FACTOR; FRAGMENT: A1 DOMAIN RESIDUES 507 - 702, OR GLYCOPROTEIN IBA (A\:ALPHA) BINDING DOMAIN; ENGINEERED: YES ? IGG1 MUS MUSCULUS 11 SASQDINKYLN 7 YTSSLHS 9 QQYEKLPWT 5 DYGVD 16 MIWGDGSTDYNSALKS 14 DPADYGNYDYALDY crystal 2.00A 17.20% FAB 23-AUG-00 20000823 IMMUNOGLOBULIN STRUCTURE DETERMINATION OF AN FAB FRAGMENT THAT NEUTRALIZES HUMAN RHINOVIRUS AND ANALYSIS OF THE FAB - VIRUS COMPLEX IMMUNOGLOBULIN STRUCTURE DETERMINATION OF AN FAB FRAGMENT THAT NEUTRALIZES HUMAN RHINOVIRUS AND ANALYSIS OF THE FAB - VIRUS COMPLEX KAPPA IGG2 MUS MUSCULUS 10 SATSSVNYMH 7 SSSNLAS 9 QQRSSYPIT 5 SFWVN 17 QIYPGDGDNKYNGKFKG 10 SGNYPYAMDY crystal 2.75A 17.40% FAB 24-MAY-94 19940524 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE HUMAN IGE - FC CEPSILON3 - CEPSILON4 FRAGMENT. ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PACGP67A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 24.20% FC 30-AUG-00 20000830 COMPLEX (ANTIBODY / PV - 1 FRAGMENT) THREE - DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE MOLECULE: FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS; ENGINEERED: YES; KAPPA IGG2 MUS MUSCULUS 16 SSSQSLVHSNGKTYLH 7 KVSNRFS 9 SQSTHVPYT 5 NYLIQ 17 VINPGSGGTDYNANFKG 11 DFYDYDVGFDY crystal 3.00A 23.00% FAB 26-JAN-95 19950126 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE, SEQUENCE, AND EPITOPE MAPPING OF A PEPTIDE COMPLEX OF AN ANTI - INFLUENZA HA PEPTIDE ANTIBODY FAB 26 (SLASH) 9: FINE - TUNING ANTIBODY SPECIFICITY MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 101 - 108); ENGINEERED: YES ? IGG2 MUS MUSCULUS 17 KSSQSLFNSGKRKNFLT 7 WASTRES 9 QNDYSHPLT 5 SFGMS 17 TISNGGGYTYYQDSVKG 11 RERYDEKGFAY crystal 2.80A 19.00% FAB 17-JAN-94 19940117 COMPLEX (RECEPTOR / IMMUNOGLOBULIN) CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; ORGAN: SERUM (MIXTURE OF SEVERAL SUBTYPES); GENE: BETA-2-MICROGLOBULIN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; EXPRESSION_SYSTEM_PLASMID: PBJ5-GS; MOL_ID: 2; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; ORGAN: SERUM (MIXTURE OF SEVERAL SUBTYPES); GENE: BETA-2-MICROGLOBULIN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; EXPRESSION_SYSTEM_PLASMID: PBJ5-GS; MOL_ID: 3; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; ORGAN: SERUM (MIXTURE OF SEVERAL SUBTYPES); GENE: BETA-2-MICROGLOBULIN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; EXPRESSION_SYSTEM_PLASMID: PBJ5-GS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 4.50A 42.30% FC 11-NOV-94 19941111 IMMUNE SYSTEM COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 MOLECULE: MAJOR POLLEN ALLERGEN BET V 1 - A; SYNONYM: BET V I - A, BETVI ALLERGEN; ENGINEERED: YES; KAPPA IGG MUS MUSCULUS 11 KASENVDTYVF 7 GPSNRYT 9 GQSYSYPYT 5 SYWIN 17 NIFPSDSYTNYNQKFKD 9 GARDTWFAY crystal 2.90A 25.30% FAB 11-SEP-00 20000911 IMMUNOGLOBULIN X - RAY STRUCTURES OF THE ANTIGEN - BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI - P185 - HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING ? KAPPA IGG1 HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.20A 18.30% FV 20-OCT-92 19921020 IMMUNOGLOBULIN X - RAY STRUCTURES OF THE ANTIGEN - BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI - P185 - HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING ? KAPPA IGG1 HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLES 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDV crystal 2.50A 17.90% FV 20-OCT-92 19921020 IMMUNOGLOBULIN X - RAY STRUCTURES OF THE ANTIGEN - BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI - P185 - HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING ? KAPPA IGG1 HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLES 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.70A 17.10% FV 20-OCT-92 19921020 LYASE / IMMUNE SYSTEM COMPLEX OF THE CAMELID HEAVY - CHAIN ANTIBODY FRAGMENT CAB - CA05 WITH BOVINE CARBONIC ANHYDRASE MOLECULE: CARBONIC ANHYDRASE; EC: 4.2.1.1; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 TYCMG 15 TILGGSTYYGDSVKG 19 STVASTGWCSRLRPYDYHY crystal 3.50A 21.00% HC-dimer 08-NOV-00 20001108 HYDROLASE INHIBITOR / HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI - HEL MONOCLONAL ANTIBODY D1.3 (VLW92A) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFASTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.85A 20.30% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR / HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI - HEL MONOCLONAL ANTIBODY D1.3 (VLW92F) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFFSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.80A 18.80% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR / HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI - HEL MONOCLONAL ANTIBODY D1.3 (VLW92H) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFHSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.75A 19.70% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR / HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI - HEL MONOCLONAL ANTIBODY D1.3 (VLW92S) MOLECULE: LYSOZYME C; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFSSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.00A 20.70% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR / HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI - HEL MONOCLONAL ANTIBODY D1.3 (VLW92V) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFVSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.90A 19.40% ? 10-NOV-00 20001110 IMMUNE SYSTEM THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3) 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A NMR N/A N/A FC 16-NOV-00 20001116 IMMUNE SYSTEM SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN - FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYDMG 17 AINWDSARTYYASSVRG 8 GEGGTWDS NMR N/A N/A HC-dimer 23-NOV-00 20001123 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYRNNGFLKH crystal 2.20A 26.80% FAB 24-NOV-00 20001124 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYRNNGFLKH crystal 2.90A 20.70% FAB 25-NOV-00 20001125 CATALYTIC ANTIBODY 48G7 HYBRIDOMA LINE FAB COMPLEXED WITH HAPTEN 5 - (PARA - NITROPHENYL PHOSPHONATE) - PENTANOIC ACID HAPTEN 5 - (PARA - NITROPHENYL PHOSPHONATE) - PENTANOIC ACID KAPPA ? HOMO SAPIENS 11 RASQEINGYLG 7 AASTLHS 9 LQYASYPRT 5 DTYMH 17 RIDPANVDTKYDPKFQD 5 YYGIY crystal 1.95A 24.40% FAB 06-FEB-96 19960206 VIRAL PROTEIN / RECEPTOR / IMMUNE SYSTEM HIV - 1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY MOLECULE: CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.50A 21.00% FAB 15-JUN-98 19980615 IMMUNOGLOBULIN MAJOR ANTIGEN - INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY ? KAPPA IGG2 MUS MUSCULUS 15 RASESVDDDGNSFLH 7 RSSNLIS 9 QQSNEDPLT 7 TYGMGVS 16 HIFWDGDKRYNPSLKS 5 EGYIY crystal 2.80A 20.00% FAB 19-JUL-93 19930719 IMMUNOGLOBULIN MAJOR ANTIGEN - INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY ? KAPPA IGG2 MUS MUSCULUS 15 RASESVDDDGNSFLH 7 RSSNLIS 9 QQSNEDPLT 7 TYGMGVS 16 HIFWDGDKRYNPSLKS 5 EGYIY crystal 2.80A 19.00% FAB 19-JUL-93 19930719 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF AN HIV - 1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN MOLECULE: HIV - 1 V3 LOOP PEPTIDE ANTIGEN; ENGINEERED: YES ? IGG2 15 RASESVDDDGNSFLH 7 RSSNLIS 9 QQSNEDPLT 7 TYGMGVS 16 HIFWDGDKRYNPSLKS 5 EGYIY crystal 2.80A 18.80% FAB 02-APR-93 19930402 ANTIBODY FAB FRAGMENT ANTI - ANTI - IDIOTYPE GH1002 FAB FRAGMENT ? ? ? MUS MUSCULUS 11 RESQDISNSLN 7 YTSRLHS 9 QQGNTLPYT 4 YGMN 17 WIQTNTEEPTYGAEFKG 7 VEAGFDY crystal 2.70A 21.00% FAB 30-NOV-95 19951130 IMMUNOGLOBULIN REFINED THREE - DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A MURINE IGG1, LAMBDA ANTIBODY ? LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SNGVH 16 VIWAGGNTNYNSALMS 14 DFYDYDVFYYAMDY crystal 2.30A 19.50% FAB 20-JAN-93 19930120 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RASQSLVNEDGNTYLF 7 YASQSIS 9 QQITDWPFT 5 SDFWS 16 FVQYSGETAYNPSLKS 5 WHGDY crystal 1.95A 21.40% FAB 27-MAR-97 19970327 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN IN COMPLEX WITH FAB FRAGMENT OF ITS MONOCLONAL ANTIBODY MAB 26 - 2F MOLECULE: ANGIOGENIN; SYNONYM: RIBONUCLEASE 5, RNASE 5; ENGINEERED: YES ? ? HOMO SAPIENS 15 RASESVDNYGISFMS 7 AASNQGS 9 QQSKEVPLT 5 SYTMS 17 TISSGGGNTYYPDSVKG 12 LGDYGYAYTMDY crystal 2.00A 23.20% FAB 19-JUN-02 20020619 IMMUNOGLOBULIN STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS ? ? ? MUS MUSCULUS 17 RSSQSLLNTRTRKSYLA 7 WASTRES 8 KQSYSLYT 5 SYAMS 17 EVSSDGSYAYYPDTLTG 7 FNWDVAY crystal 2.60A 21.26% FAB 12-SEP-02 20020912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC - FRAGMENT,GLYCOFORM (MN2F) 2 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 28.00% FC 19-SEP-02 20020919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC - FRAGMENT,GLYCOFORM (M3N2F) 2 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 25.30% FC 19-SEP-02 20020919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC - FRAGMENT,GLYCOFORM (G2F) 2,SG P212121 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.10A 24.00% FC 19-SEP-02 20020919 IMMUNE SYSTEM STRUCTURAL ANALYSIS OF HUMAN IGG - FC GLYCOFORMS REVEALS A CORRELATION BETWEEN GLYCOSYLATION AND STRUCTURAL INTEGRITY ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.85A 27.90% ? 19-SEP-02 20020919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC - FRAGMENT,GLYCOFORM (G0F) 2 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.44A 27.80% FC 19-SEP-02 20020919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMAN IGG1 FC - FRAGMENT,HIGH SALT CONDITION ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 4.10A 28.50% FC 19-SEP-02 20020919 ANTIBODY THREE - DIMENSIONAL STRUCTURE OF ANTI - AMPICILLIN SINGLE CHAIN FV FRAGMENT FROM PHAGE - DISPLAYED MURINE ANTIBODY LIBRARIES ? ? ? MUS MUSCULUS 11 CKASQDVGTAV 7 YWASTRH 10 CQQYSSYPLT 5 GTAVA 13 LLIYWASTRHTGV 26 YSSYPLTFGAGTKLELQVQLQESGGE crystal 1.87A 23.30% scFv 14-FEB-01 20010214 ANTIBODY THREE - DIMENSIONAL STRUCTURE OF ANTI - AMPICILLIN SINGLE CHAIN FV FRAGMENT. ? ? ? MUS MUSCULUS 11 KASQDVGTAVA 7 WASTRHT 9 QQYSSYPLT 3 TAV 13 KLLIYWASTRHTG 26 QYSSYPLTFGAGTKLELKRGVQLQEP crystal 2.75A 17.80% scFv 14-FEB-01 20010214 ANTI - AMPICILLIN ANTIBODIES THREE - DIMENSIONAL STRUCTURE OF ANTI - AMPICILLIN SINGLE CHAIN FV FRAGMENT COMPLEXED WITH THE HAPTEN. THE HAPTEN. ? ? MUS MUSCULUS 11 KASQDVGTAVA 7 WASTRHT 9 QQYSSYPLT 3 TAV 13 KLLIYWASTRHTG 26 QYSSYPLTFGAGTKLELKRGVQLQEP crystal 2.40A 20.40% scFv 15-FEB-01 20010215 IMMUNOGLOBULIN LLAMA HEAVY CHAIN VARIABLE DOMAIN AGAINST ALPHA SUBUNIT OF HCG (HUMAN CHORIONIC GONADOTROPIN) ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYDMG 17 AINWDSARTYYASSVRG 8 GEGGTWDS crystal 1.85A 24.30% HC-dimer 13-JUL-96 19960713 MOL_ID: 1; MOLECULE: KAPPA LIGHT CHAIN OF IG; CHAIN: A, C; FRAGMENT: 1 - 214; MOL_ID: 2; MOLECULE: HEAVY CHAIN OF IG; CHAIN: B, D; FRAGMENT: 501 - 724; MOL_ID: 3; MOLECULE: PROTEIN L; CHAIN: E; FRAGMENT: 820 - 880 MOLECULE: PROTEIN L; FRAGMENT: 820 - 880 KAPPA ? HOMO SAPIENS 11 RTSQSISSYLN 7 AASSLQS 9 QQSYSTPRT 5 GYGMH 17 LISYDESNKYYADSVKG 12 VKFYDPTAPNDY crystal 2.70A 21.50% ? 27-NOV-00 20001127 IMMUNE SYSTEM ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MOLECULE: PEP - 4; OTHER_DETAILS: EPITOPE - RELATED PEPTIDE KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.60A 29.40% FAB 21-DEC-00 20001221 IMMUNE SYSTEM / PEPTIDE ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MOLECULE: PEP - 2; OTHER_DETAILS: EPITOPE - RELATED PEPTIDE KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.70A 28.20% FAB 21-DEC-00 20001221 IMMUNE SYSTEM / PEPTIDE ANTI - P24 (HIV - 1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MOLECULE: PEPTIDE 5; OTHER_DETAILS: EPITOPE - RELATED PEPTIDE KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.55A 28.40% FAB 02-JAN-01 20010102 IMMUNOGLOBULIN STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIGEN - ANTIBODY RECOGNITION ? KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 2.00A 19.50% FAB 08-JUL-92 19920708 IMMUNOGLOBULIN STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY - ANTIGEN RECOGNITION MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 100 - 108); ENGINEERED: YES; KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 2.90A 20.00% FAB 08-JUL-92 19920708 IMMUNOGLOBULIN STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY - ANTIGEN RECOGNITION MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 100 - 107); ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 3.10A 22.00% FAB 08-JUL-92 19920708 CATALYTIC ANTIBODY FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY ? ? ? HOMO SAPIENS 11 RASQEINGYLG 7 AASTLHS 9 LQYASYPRT 5 DTYMH 17 RIDPANVDTKYDPKFQD 5 YYGIY crystal 2.68A 18.40% FAB 20-DEC-96 19961220 IMMUNE SYSTEM STRUCTURE OF NATIVE CATALYTIC ANTIBODY HA5 - 19A4 ? ? ? MUS MUSCULUS 12 SASSSVSSNYVY 7 STSNLAS 9 LQWSSFPYT 6 SGYAWN 16 YIRYSGDTRYNPSLKS 7 GYGNSDY crystal 2.70A 22.50% FAB 14-DEC-00 20001214 TRANSFERASE / DNA - RNA HYBRID CRYSTAL STRUCTURE OF HIV - 1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA MOLECULE: HIV - 1 REVERSE TRANSCRIPTASE; FRAGMENT: P51; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.00A 27.40% FAB 22-JAN-01 20010122 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV - 1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN ? ? IGG HOMO SAPIENS 12 RSSHSIRSRRVA 7 GVSNRAS 9 QVYGASSYT 5 NFVIH 17 WINPYNGNKEFSAKFQD 18 VGPYSWDDSPQDNYYMDV crystal 2.70A 22.90% ? 24-JAN-01 20010124 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS; MOL_ID: 2; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS; MOL_ID: 3; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS; MOL_ID: 4; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 22.20% FC 31-JAN-01 20010131 IMMUNE SYSTEM NON - FCRN BINDING FC FRAGMENT OF RAT IGG2A ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_ORGAN: OVARY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 24.10% FC 31-JAN-01 20010131 ANTIBIOTIC CRYSTAL STRUCTURE OF AN AMPICILLIN SINGLE CHAIN FV, FORM 1, FREE ? ? ? MUS MUSCULUS 11 KASQDVGTAVA 7 WASTRHT 9 QQYSSYPLT 5 SYWIN 17 NIYPSDSYTNYNQKFKD 3 WGY crystal 2.44A 17.50% FV 15-FEB-01 20010215 IMMUNE SYSTEM THREE - DIMENSIONAL STRUCTURE OF A LLAMA VHH DOMAIN COMPLEXED WITH THE DYE RR1 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYVIG 19 TIGRNLVGPSDFYTRYADS 18 CAAKTTTWGGNDPNNWNY crystal 1.95A 23.20% HC-dimer 16-FEB-01 20010216 IMMUNE SYSTEM THREE - DIMENSIONAL STRUCTURE OF A LAMA VHH DOMAIN UNLIGANDED ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYVIG 19 TIGRNLVGPSDFYTRYADS 18 CAAKTTTWGGNDPNNWNY crystal 2.03A 21.20% HC-dimer 16-FEB-01 20010216 IMMUNE SYSTEM ANTIBODY GNC92H2 BOUND TO LIGAND AND MOUSE VARIABLE REGION; ENGINEERED: YES; OTHER_DETAILS: THE CHIMERA CONSISTS OF RESIDUES 1 - 108 OF MOUSE PORTION AND 109 - 214 OF HUMAN PORTION OF IG KAPPA CHAIN.; KAPPA ? MUS MUSCULUS, HOMO SAPIENS 15 RASKSVSTSGYNYMH 7 LASNLAS 10 LYSREFPPWT 5 NYGMN 17 WINTYTGEPTYADDFRG 8 YDSPLGDY crystal 2.30A 22.00% ? 12-MAR-01 20010312 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT ROOM TEMPERATURE MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; FRAGMENT: N - TERMINAL FRAGMENT; SYNONYM: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 KFGMS 17 SISTGGYNTYYSDNVKG 11 GYSSTSYAMDY crystal 2.40A 15.60% FV 14-MAR-01 20010314 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; FRAGMENT: N - TERMINAL FRAGMENT; SYNONYM: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 KFGMS 17 SISTGGYNTYYSDNVKG 11 GYSSTSYAMDY crystal 1.80A 17.20% FV 14-MAR-01 20010314 IMMUNE SYSTEM / DNA CRYSTAL STRUCTURE OF A RECOMBINANT ANTI - SINGLE - STRANDED DNA ANTIBODY FRAGMENT COMPLEXED WITH DT5 MOLECULE: 5' - D (P *TP *T) - 3'; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GGYRPYYAMDY crystal 2.10A 22.00% FAB 14-MAR-01 20010314 IMMUNE SYSTEM NATIVE CRYSTAL STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI - TESTOSTERONE FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNSYLE 7 KVSNRFS 9 FQGSHVPPT 5 TYALS 16 SIVSGGNTYYSGSVKG 10 EYYGYVGLAY crystal 2.72A 19.50% FAB 20-MAR-01 20010320 IMMUNE SYSTEM TESTOSTERONE COMPLEX STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI - TESTOSTERONE FAB FRAGMENT STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI - TESTOSTERONE FAB FRAGMENT ? ? MUS MUSCULUS 16 RSSQSIVHSNGNSYLE 7 KVSNRFS 9 FQGSHVPPT 5 TYALS 16 SIVSGGNTYYSGSVKG 10 EYYGYVGLAY crystal 2.60A 18.80% FAB 20-MAR-01 20010320 CYTOKINE / IMMUNE SYSTEM STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY MOLECULE: CD40 LIGAND; FRAGMENT: RESIDUES 116 - 261; SYNONYM: CD40 - L; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASQRVSSSTYSYMH 7 YASNLES 9 QHSWEIPPT 5 SYYMY 17 EINPSNGDTNFNEKFKS 9 SDGRNDMDS crystal 3.10A 23.30% FAB 20-MAR-01 20010320 730.1.4 VIRUS NEUTRALIZING ANTIBODY 409.5.3 ANTI-IDIOTYPIC ANTIBODY ? IGG1 MUS MUSCULUS 11 KASQDVSTAVA 7 SASYQYT 9 HQHYSTPFT 5 NYGMN 17 WINTYTGEPTYADDFKG 12 DGYYENYYAMDY crystal 2.90A 21.00% FAB 28-DEC-93 19931228 409.5.3 ANTI-IDIOTYPIC ANTIBODY 730.1.4 VIRUS NEUTRALIZING ANTIBODY ? IGG2A MUS MUSCULUS 12 SVSSSISSSNLH 7 GTSNLAS 9 QQWNSYPYT 5 NYWMS 19 EIRLNSDNFATHYAESVKG 10 RPLFYYAVDY crystal 2.90A 21.00% FAB 28-DEC-93 19931228 IMMUNE SYSTEM STRUCTURE AND SPECIFICITY OF THE ANTI - DIGOXIN ANTIBODY 40 - 50 ? KAPPA IGG2 MUS MUSCULUS 15 RASKSVSTSGYSHIH 7 LASILES 9 QHSREYPLT 5 TYGVH 16 LIWAGGNTDYNSALMS 13 FRFASYYDYAVDY crystal 2.70A 20.90% FAB 25-OCT-94 19941025 PROTEIN BINDING / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HD32A) - HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA IGG1 MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SAYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.50A 18.10% FV 30-MAR-01 20010330 PROTEIN BINDING / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HD99A) - HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA IGG1 MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WAGDY crystal 2.30A 16.50% FV 30-MAR-01 20010330 PROTEIN BINDING / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HD32A99A) - HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA IGG1 MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SAYWS 16 YVSYSGSTYYNPSLKS 5 WAGDY crystal 2.10A 17.70% FV 30-MAR-01 20010330 IMMUNE SYSTEM SOLUTION STRUCTURE OF A SOLUBLE SINGLE - DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL / VH INTERFACE ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYHMA 17 TINPGDGSTYYADSVKG 8 YSGGALDA NMR N/A N/A HC-dimer 09-APR-01 20010409 IMMUNOGLOBULIN A DETAILED ANALYSIS OF THE FREE AND BOUND CONFORMATION OF AN ANTIBODY: X - RAY STRUCTURES OF ANTI - PEPTIDE FAB 17 (SLASH) 9 AND THREE DIFFERENT FAB - PEPTIDE COMPLEXES MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 101 - 107); ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 2.80A 17.00% FAB 06-MAY-93 19930506 IMMUNOGLOBULIN MODEL OF HUMAN IGA1 DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING MOLECULE: IGA1; FRAGMENT: CHAINS A AND B, HEAVY, CHAINS C AND D, LIGHT ? IGA HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 5 SYGLH 17 WISAGTGNTKYSQKFRG 12 DPYGGGKSEFDY model N/A N/A ? 23-DEC-98 19981223 COMPLEX (ANTIBODY / BINDING PROTEIN) IGG1 FAB FRAGMENT (MOPC21) COMPLEX WITH DOMAIN III OF PROTEIN G FROM STREPTOCOCCUS MOLECULE: STREPTOCOCCAL PROTEIN G (DOMAIN III); ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 KASENVVTYVS 7 GASNRYT 9 GQGNSYPYT 5 SFGMH 17 YISSGSSTLHYADTVKG 11 WGNYPYYAMDY crystal 2.60A 16.80% FAB 05-AUG-94 19940805 IMMUNOGLOBULIN CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS KAPPA IGG1 MUS MUSCULUS 16 RSNQTILLSDGDTYLE 7 KVSNRFS 9 FQGSHVPPT 5 RCAMS 17 GISSGGSYTFYPDTVKG 10 YSSDPFYFDY crystal 2.80A 18.00% FAB 21-MAR-91 19910321 IMMUNOGLOBULIN 26 - 10 FAB:DIGOXIN COMPLEX - AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 5 DFYMN 17 YISPYSGVTGYNQKFKG 10 SSGNKWAMDY crystal 2.70A 17.70% FAB 19-FEB-93 19930219 IMMUNOGLOBULIN 26 - 10 FAB:DIGOXIN COMPLEX - AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 5 DFYMN 17 YISPYSGVTGYNQKFKG 10 SSGNKWAMDY crystal 2.50A 17.60% FAB 19-FEB-93 19930219 IMMUNOGLOBULIN THREE DIMENSIONAL STRUCTURE OF AN FV FROM A HUMAN IGM IMMUNOGLOBULIN ? KAPPA IGM HOMO SAPIENS 11 QASQDISNYLA 7 DASNLET 9 QQYQNLPLT 5 IFVMS 17 GVFGSGGNTDYADAVKG 12 HRVSYVLTGFDS crystal 2.30A 20.10% FV 10-JUL-92 19920710 IMMUNOGLOBULIN STRUCTURE OF IMMUNOGLOBULIN ? ? IGG2 MUS MUSCULUS 11 HASQNINVWLS 7 KASNLHT 9 QQGQSYPLT 5 DYYMY 17 YISNGGGSTYYPDTVKG 9 HGGYYAMDY crystal 2.80A 20.90% ? 25-OCT-96 19961025 IMMUNOGLOBULIN STRUCTURE OF IMMUNOGLOBULIN ? ? IGG1 MUS MUSCULUS 11 KASENVVTYVS 7 GASNRYT 9 GQGYSYPYT 5 TYTIH 17 YINPSSVYTNYNQRFKD 6 EGEVPY crystal 3.20A 21.10% ? 09-OCT-97 19971009 IMMUNE SYSTEM / IMMUNOSUPPRESSANT A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X - RAY STRUCTURE OF A CYCLOSPORIN - FAB COMPLEX MOLECULE: CYCLOSPORIN A; SYNONYM: CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE; ENGINEERED: YES KAPPA IGG1 HOMO SAPIENS 11 RASQDISTYLN 7 YTSRLRS 9 QQGSRIPPT 5 DYYMY 17 FISNGGGSAFYADIVKG 17 HTLYDTLYGNYPVWFAD crystal 2.50A 16.40% FAB 09-DEC-93 19931209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF G3 - 519, AN ANTI - HIV MONOCLONAL ANTIBODY ? ? ? MUS MUSCULUS 17 KSSQSLLYSRNQMNYLS 7 WASTRES 8 QQYYHYRT 5 DYYIH 17 WLDPENGDTESAPKFQG 12 ISTTRDYYALDY crystal 2.20A 18.80% FAB 07-MAY-01 20010507 IMMUNOGLOBULIN HOW THE ANTI - (METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X - RAY STRUCTURES FOR TWO FAB' (SLASH) HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE ES WITH DIFFERENT METALS IN THE CHELATE LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNLWV 5 GETMS 17 TTLSGGGFTFYSASVKG 5 HRFVH crystal 2.20A 18.80% FAB 14-JUN-93 19930614 IMMUNOGLOBULIN HOW THE ANTI - (METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X - RAY STRUCTURES FOR TWO FAB' (SLASH) HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE ES WITH DIFFERENT METALS IN THE CHELATE LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNLWV 5 GETMS 17 TTLSGGGFTFYSASVKG 5 HRFVH crystal 2.80A 17.60% FAB 14-JUN-93 19930614 IMMUNE SYSTEM / BLOOD CLOTTING HUMAN FACTOR VIII C2 DOMAIN COMPLEXED TO HUMAN MONOCLONAL BO2C11 FAB. MOLECULE: HUMAN FACTOR VIII; FRAGMENT: C - TERMINAL DOMAIN; SYNONYM: COAGULATION FACTOR VII; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 12 RASQSFSSSYLA 7 GASTRAT 9 QKYGTSAIT 5 ELPVH 17 SFDPESGESIYAREFQG 8 PDPDAFDI crystal 2.00A 20.30% FAB 21-JUL-01 20010721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MOUSE ANTI - HUMAN FAS ANTIBODY HFE7A ? ? ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 12 NRDYSNNWYFDV crystal 2.50A 16.80% FAB 10-AUG-01 20010810 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTIGEN - BINDING FRAGMENT FROM A HUMANIZED VERSION OF THE ANTI - HUMAN FAS ANTIBODY HFE7A ? ? ? MUS MUSCULUS, HOMO SAPIENS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 12 NRDYSNNWYFDV crystal 2.80A 20.20% FAB 11-JAN-02 20020111 IMMUNOGLOBULIN THE DE NOVO DESIGN OF AN ANTIBODY COMBINING SITE: CRYSTALLOGRAPHIC ANALYSIS OF THE VL DOMAIN CONFIRMS THE STRUCTURAL MODEL ? KAPPA IGG MUS MUSCULUS 11 RASQSIGNRLF 7 YASQSIS 9 QQVSEWPFT 0 N/A 0 N/A 0 N/A crystal 2.17A 17.50% LC-dimer 04-MAY-94 19940504 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF ANTI - CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY T84.66 FV FRAGMENT ? ? ? MUS MUSCULUS 15 RAGESVDIFGVGFLH 7 RASNLES 9 QQTNEDPYT 5 DTYMH 17 RIDPANGNSKYVPKFQG 12 FGYYVSDYAMAY crystal 1.50A 19.00% FV 01-NOV-02 20021101 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT LY50F COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 FASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 19.00% FV 13-DEC-02 20021213 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT LS91A COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQANSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 19.10% FV 13-DEC-02 20021213 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT LS93A COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNAWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 18.90% FV 20-DEC-02 20021220 TRANSFERASE / IMMUNE SYSTEM / DNA CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV - 1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE - PRIMER MOLECULE: REVERSE TRANSCRIPTASE; SYNONYM: HIV - 1 RT; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.50A 26.20% FAB 24-MAY-02 20020524 IMMUNE SYSTEM ANTIGEN - BINDING FRAGMENT OF THE MURINE ANTI - PHENYLARSONATE ANTIBODY 36 - 71, "FAB 36 - 71" ? ? ? MUS MUSCULUS 11 RASQDINNFLN 7 FTSRSQS 9 QQGNALPRT 5 SNGIN 17 YNNPGNGYITYNEKFKG 12 SEYYGGSYKFDY crystal 1.90A 19.60% FAB 21-JUN-01 20010621 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IMMUNOGLOBULIN FAB FRAGMENT COMPLEXED WITH 17 - BETA - ESTRADIOL MOLECULE: IG KAPPA - CHAIN; ENGINEERED: YES; KAPPA ? MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 HHFWSTPWT 3 GMQ 17 WLNTQSGVPEYAEDFKG 7 WGGNSAY crystal 2.15A 19.90% FAB 26-JUN-01 20010626 IMMUNE SYSTEM STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4 ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 5 GYAMS 16 SIYNGFRIHYLDSVKG 10 GDAYSRYFDV crystal 1.80A 20.90% ? 26-JUN-01 20010626 IMMUNE SYSTEM STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4 ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 5 GYAMS 16 SIYNGFRIHYLDSVKG 10 GDAYSRYFDV crystal 1.85A 20.60% ? 26-JUN-01 20010626 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-ESTRADIOL ANTIBODY 57-2 MOLECULE: IG GAMMA-1-CHAIN; FRAGMENT: RESIDUES 1-215; ENGINEERED: YES KAPPA GAMMA MOUSE 11 RASGNIHNYLA 7 NAKTLAD 9 HHFWSTPWT 5 TSGMQ 17 WLNTQSGVPEYAEDFKG 7 WGGNSAY crystal 2.51A 19.80% FAB 28-JUN-01 20010628 COMPLEX (ANTIBODY - ANTIGEN) THREE - DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN - ANTIBODY CROSS - REACTION COMPLEX MOLECULE: PHEASANT EGG WHITE LYSOZYME; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 RASKSISKSLA 7 SGSTLQS 9 QQHNEYPWT 5 SYWIN 17 NIYPSDSYTNYNQKFKD 9 DDNYGAMDY crystal 2.40A 21.40% FV 04-MAY-93 19930504 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB - ESTRADIOL COMPLEXES ES LAMBDA ? MUS MUSCULUS 14 RSSSGAITTSHYAN 7 GTNNRAP 9 ALWFSNQFI 5 TYWMQ 17 AIYPGDDDARYTQKFKG 10 GRSLYYTMDY crystal 2.70A 22.30% FAB 23-JUL-01 20010723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB - ESTRADIOL COMPLEXES ES LAMBDA ? MUS MUSCULUS 14 RSSSGAITTSHYAN 7 GTNNRAP 9 ALWFSNQFI 5 TYWMQ 17 AIYPGDDDARYTQKFKG 10 GRSLYYTMDY crystal 2.85A 19.80% FAB 24-JUL-01 20010724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB - ESTRADIOL COMPLEXES ES KAPPA ? MUS MUSCULUS 11 RASGNIYNYLA 7 NAKTLVD 9 HHFWNTPYT 5 DTYMF 17 RINPANGISKYDPRFQG 5 EKDLP crystal 3.00A 19.50% FAB 24-JUL-01 20010724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB - ESTRADIOL COMPLEXES ES KAPPA ? MUS MUSCULUS 11 RASGNIYNYLA 7 NAKTLVD 9 HHFWNTPYT 5 DTYMF 17 RINPANGISKYDPRFQG 5 EKDLP crystal 3.20A 21.10% FAB 24-JUL-01 20010724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SINGLE - CHAIN FV FRAGMENT 1696 IN COMPLEX WITH THE EPITOPE PEPTIDE CORRESPONDING TO N - TERMINUS OF HIV - 1 PROTEASE MOLECULE: EPITOPE PEPTIDE CORRESPONDING TO N - TERMINUS OF HIV - 1 PROTEASE; ENGINEERED: YES; OTHER_DETAILS: NONAPEPTIDE PQITLWQRR KAPPA IGG1 MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.70A 22.90% scFv 01-AUG-01 20010801 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TISSUE FACTOR IN COMPLEX WITH HUMANIZED FAB D3H44 MOLECULE: TISSUE FACTOR; FRAGMENT: EXTRACELLULAR DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASRDIKSYLN 7 YATSLAE 9 LQHGESPWT 5 EYYMH 17 LIDPEQGNTIYDPKFQD 8 DTAAYFDY crystal 1.85A 20.10% FAB 03-AUG-01 20010803 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB D3H44 ? ? ? HOMO SAPIENS 11 RASRDIKSYLN 7 YATSLAE 9 LQHGESPWT 5 EYYMH 17 LIDPEQGNTIYDPKFQD 8 DTAAYFDY crystal 1.85A 18.20% FAB 03-AUG-01 20010803 MOL_ID: 1; MOLECULE: ANTIBODY A6; CHAIN: L; FRAGMENT: FAB FRAGMENT;PEPSIN DIGESTION OF INTACT ANTIBODY; MOL_ID: 2; MOLECULE: ANTIBODY A6; CHAIN: H; FRAGMENT: FAB FRAGMENT;PEPSIN DIGESTION OF INTACT ANTIBODY; MOL_ID: 3; MOLECULE: INTERFERON - GAMMA RECEPTOR ALPHA CHAIN; CHAIN: I; FRAGMENT: N - TERMINAL DOMAIN; ENGINEERED: YES; MUTATION: YES MOLECULE: INTERFERON - GAMMA RECEPTOR ALPHA CHAIN; FRAGMENT: N - TERMINAL DOMAIN; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 KASEDIYNRLA 7 GATSLET 8 QQYWSTWT 7 TYGMGVG 16 HIWWDDDKYYNPSLKS 12 RAPFYGNHAMDY crystal 2.80A 24.60% FAB 23-SEP-97 19970923 ANTIBODY,HYDROLASE DEGENERATE INTERFACES IN ANTIGEN - ANTIBODY COMPLEXES MOLECULE: LYSOZYME; FRAGMENT: ENZYME; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 2.50A 17.30% HC-dimer 21-AUG-01 20010821 ANTIBODY, HYDROLASE DEGENERATE INTERFACES IN ANTIGEN - ANTIBODY COMPLEXES MOLECULE: LYSOZYME C; FRAGMENT: ENZYME; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 1.90A 18.40% HC-dimer 21-AUG-01 20010821 IMMUNE SYSTEM, LYSOZYME DEGENERATE INTERFACES IN ANTIGEN - ANTIBODY COMPLEXES MOLECULE: LYSOZYME; FRAGMENT: ENZYME; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 2.10A 16.40% HC-dimer 22-AUG-01 20010822 IMMUNE SYSTEM THREE - DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR ? LAMBDA ? HOMO SAPIENS 14 TGVSSIVGSYNLVS 7 EVNKRPS 11 SSYDGSSTSVV 0 N/A 0 N/A 0 N/A crystal 1.94A 22.30% LC-dimer 30-AUG-01 20010830 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN HIGH CONCENTRATION OF K+ MOLECULE: POTASSIUM CHANNEL KCSA; FRAGMENT: POTASSIUM CHANNEL KCSA; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.00A 21.80% FAB 07-OCT-01 20011007 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN LOW CONCENTRATION OF K+ MOLECULE: POTASSIUM CHANNEL KCSA; FRAGMENT: POTASSIUM CHANNEL KCSA; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.30A 21.80% FAB 07-OCT-01 20011007 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY FAB FRAGMENT D3 ? ? ? MUS MUSCULUS 11 KASRDIKSYLS 7 YATSLAD 9 LQHGESPFT 5 DYYMH 17 WIDPENGNTIYDPKFQD 8 DTAAYFDY crystal 2.40A 22.50% FAB 17-OCT-01 20011017 COMPLEX (IMMUNOGLOBULIN/RECEPTOR) MURINE T-CELL RECEPTOR VARIABLE DOMAIN/FAB COMPLEX MOLECULE: KB5-C20 T-CELL ANTIGEN RECEPTOR; FRAGMENT: FV FRAGMENT, VARIABLE DOMAIN; SYNONYM: TCR VAPLHA VBETA DOMAIN; ENGINEERED: YES; OTHER_DETAILS: 24 RESIDUE LINK BETWEEN VALPHA C-TERMINUS AND VBETA N-TERMINUS; ? Gamma 2A MUS MUSCULUS 11 RASKNIYSYLA 7 NAKTLGE 9 QHHYGTPYT 5 GYNMN 17 NIDPYYGGISYNQKFKG 10 SRTDLYYFDY crystal 2.50A 22.10% FAB 06-APR-97 19970406 OXIDOREDUCTASE / ELECTRON TRANSPORT YEAST CYTOCHROME BC1 COMPLEX MOLECULE: UBIQUINOL - CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN 2; FRAGMENT: RESIDUES 17 - 368; EC: 1.10.2.2; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 2.30A 21.80% FV 05-NOV-01 20011105 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE MOLECULE: PS1 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASENVDTYVS 7 GASNRYT 9 GQSYSYPLT 6 SDYAWN 16 YISYSGSTTYNPSLKS 7 GGTGFDY crystal 2.50A 19.50% ? 07-NOV-01 20011107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC283 IN COMPLEX WITH PS1 PEPTIDE MOLECULE: PS1 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 8 GQTYSYPT 6 SDYAWN 16 YIRNGGSTTYNPSLAS 7 GGTGFTY crystal 2.90A 18.40% ? 11-NOV-01 20011111 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC282 IN COMPLEX WITH PS1 PEPTIDE MOLECULE: PS1 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 9 GQSYSSPLT 6 SDYAWN 16 YISYSGSTSYNPSLKS 7 GGTGFPY crystal 2.50A 20.90% ? 11-NOV-01 20011111 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC287 ? ? ? MUS MUSCULUS 11 KASENVDTYVS 7 GASNRYT 9 GQSYSYPLT 6 SDYAWN 16 YISYSGSTTYNPSLKS 7 GGTGFDY crystal 2.20A 20.00% ? 11-NOV-01 20011111 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC282 ? ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 9 GQSYSSPLT 6 SDYAWN 16 YISYSGSTSYNPSLKS 7 GGTGFPY crystal 1.80A 20.30% FAB 11-NOV-01 20011111 IMMUNE SYSTEM / DNA ANTIBODY 64M - 2 FAB COMPLEXED WITH DTT (6 - 4) TT MOLECULE: 5' - D ( *TP * (64T) P *TP *T) - 3'; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 8 FQGSLVPT 5 SFWMH 17 TIYPGNSDTSYNQKFKG 11 RSGYKYYALDY crystal 2.40A 20.10% FAB 15-NOV-01 20011115 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 28B4 FAB FRAGMENT COMPLEXED WITH HAPTEN (1 - [N - 4' - NITROBENZYL - N - 4' - CARBOXYBUTYLAMINO] METHYLPHOSPHONIC ACID) HAPTEN (1 - [N - 4' - NITROBENZYL - N - 4' - CARBOXYBUTYLAMINO] METHYLPHOSPHONIC ACID) ? ? MUS MUSCULUS 16 RFSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYFN 19 FIRNKAKGYTTEYSASVKG 8 WGSYAMDY crystal 1.90A 19.90% FAB 16-APR-96 19960416 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 28B4 FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RFSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYFN 19 FIRNKAKGYTTEYSASVKG 8 WGSYAMDY crystal 2.20A 18.30% FAB 16-APR-96 19960416 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: FAB FRAGMENT OF ANTIBODY; OTHER_DETAILS: BROMELAIN DIGESTED; ? ? MUS MUSCULUS 12 SASSTITSSFLY 7 STSNLAS 9 HQWETFPRT 6 SGYYWT 16 YISYDGSNNYNPSLKN 11 FYYDYDFFFDY crystal 3.50A 25.50% FAB 16-NOV-01 20011116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT COMPLEXED WITH GIBBERELLIN A4 GIBBERELLIN A4 ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSSRFS 9 SQSTHVPFT 5 SYAMS 16 TITTRGYTFYPDSVKG 12 EGLLLDYFTMDY crystal 2.80A 23.50% FAB 20-NOV-01 20011120 COMPLEX (IMMUNOGLOBULIN / HYDROLASE) FV MUTANT Y (B 32) A (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GAGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.10A 16.20% FV 23-OCT-96 19961023 COMPLEX (IMMUNOGLOBULIN / HYDROLASE) FV MUTANT Y (B 101) F (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDFRLDY crystal 1.85A 18.10% FV 23-OCT-96 19961023 COMPLEX (IMMUNOGLOBULIN / HYDROLASE) FV MUTANT Y (A 50) S (VL DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 STTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.00A 16.70% FV 23-OCT-96 19961023 IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 1.90A 21.30% ? 18-DEC-01 20011218 IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 1.90A 21.30% ? 18-DEC-01 20011218 CATALYTIC ANTIBODY CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE - LIKE ABZYMES OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE - LIKE ABZYMES ? IGG2 MUS MUSCULUS 11 RASQEISGYLS 7 AASTLDS 9 LQYASSPYT 5 SFGMH 17 YISSGSSTIYYADTVKG 10 GDYYGSRGAY crystal 3.20A 20.00% FAB 11-SEP-95 19950911 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - HIS TAG ANTIBODY 3D5 SINGLE - CHAIN FRAGMENT (SCFV) IN COMPLEX WITH A OLIGOHISTIDINE PEPTIDE MOLECULE: PEPTIDE LINKER; ENGINEERED: YES; OTHER_DETAILS: THE PEPTIDE LINKER CONNECTS THE VARIABLE LIGHT CHAIN AND THE VARIABLE HEAVY CHAIN.; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMN 17 DINPNNGGTSYNQKFKG 5 QSGAY crystal 2.70A 19.00% FV 17-JAN-02 20020117 HYDROLASE, IMMUNE SYSTEM CAMELID VHH DOMAINS IN COMPLEX WITH PORCINE PANCREATIC ALPHA - AMYLASE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: SUS SCROFA; ORGANISM_COMMON: PIG; ORGANISM_TAXID: 9823; OTHER_DETAILS: PANCREATIC ENZYME; MOL_ID: 2; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; GENE: IGG VHH; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN6 0 0 0 0 0 0 crystal 2.00A 20.30% VHH 01-FEB-02 20020201 HYDROLASE, IMMUNE SYSTEM CAMELID VHH DOMAINS IN COMPLEX WITH PORCINE PANCREATIC ALPHA - AMYLASE MOLECULE: ALPHA - AMYLASE, PANCREATIC; SYNONYM: 1,4 - ALPHA - D - GLUCAN GLUCANOHYDROLASE; EC: 3.2.1.1; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 TYDMS 16 GIDNDGTTTYVDSVAG 13 SLRYGLPGCPIIP crystal 1.60A 20.50% HC-dimer 01-FEB-02 20020201 OXIDOREDUCTASE / ELECTRON TRANSPORT YEAST CYTOCHROME BC1 COMPLEX WITH BOUND SUBSTRATE CYTOCHROME C MOLECULE: UBIQUINOL - CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN 2; FRAGMENT: RESIDUES 17 - 368; EC: 1.10.2.2; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 2.97A 22.90% FV 05-FEB-02 20020205 IMMUNE SYSTEM FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B - DOMAIN FROM PROTEIN A CALLED Z34C ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL: OVARY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; SYNTHETIC: YES; OTHER_DETAILS: PHAGE OPTIMIZED SEQUENCE FROM THE B-DOMAIN OF PROTEIN A STAPHYLOCOCCUS AUREUS. PEPTIDE PREPARED USING N-FLUORENYL- METHOXYCARBONYL CHEMISTRY ON WANG RESIN. 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.65A 20.60% FC 14-MAR-02 20020314 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - ERBB2 FAB2C4 THE CHIMERA CONSISTS OF THE HUMAN IG AND THE ORIGINAL MURINE SEQUENCE; ? ? HOMO SAPIENS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQRFKG 10 NLGPSFYFDY crystal 1.80A 19.70% FAB 15-MAR-02 20020315 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - TESTOSTERONE FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RSSEVIVTRNGYTPIE 7 KAYKRFP 9 FDGSTVPPK 5 RYALS 16 SIVSGGNTYYSGSVKG 10 AYYGYVGLVH crystal 2.10A 21.30% FAB 17-MAR-02 20020317 IMMUNE SYSTEM STRUCTURE OF A HUMAN BENCE - JONES DIMER CRYSTALLIZED IN U.S. SPACE SHUTTLE MISSION STS - 95: 100K ? LAMBDA ? HOMO SAPIENS 14 TGVSSIVGSYNLVS 7 EVNKRPS 11 SSYDGSSTSVV 0 N/A 0 N/A 0 N/A crystal 1.95A 20.00% LC-dimer 16-APR-02 20020416 IMMUNE SYSTEM STRUCTURE OF A HUMAN BENCE - JONES DIMER CRYSTALLIZED IN U.S. SPACE SHUTTLE MISSION STS - 95: 293K ? LAMBDA ? HOMO SAPIENS 14 TGVSSIVGSYNLVS 7 EVNKRPS 11 SSYDGSSTSVV 0 N/A 0 N/A 0 N/A crystal 2.30A 17.30% LC-dimer 17-APR-02 20020417 IMMUNOGLOBULIN BENCE JONES PROTEIN CLE, A LAMBDA III IMMUNOGLOBULIN LIGHT - CHAIN DIMER MOLECULE: LAMBDA III BENCE JONES PROTEIN CLE; LAMBDA ? HOMO SAPIENS 11 SGEKLGDAYVC 7 QDNRRPS 10 QVWDSNASVV 0 N/A 0 N/A 0 N/A crystal 2.65A 20.00% LC-dimer 13-MAY-96 19960513 IMMUNE SYSTEM ENGINEERED HUMAN INTERLEUKIN - 10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT MOLECULE: INTERLEUKIN - 10; FRAGMENT: RESIDUES 26 - 175; SYNONYM: IL - 10M1 (ENGINEERED MONOMER OF HUMAN INTERLEUKIN - 10) , IL - 10, CYTOKINE SYNTHESIS INHIBITORY FACTOR, CSIF; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 11 KASESVTSRMH 7 KASNLAS 9 QQSWNGPLT 5 DFYIH 17 YINPNSGYTNYNEKFKN 10 GVPGNNWFPY crystal 1.91A 18.70% FAB 23-APR-02 20020423 IMMUNOGLOBULIN THE STRUCTURE OF A BIVALENT DIABODY MOLECULE: ANTI - PHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE C DIABODY; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.60A 20.00% scFv 29-AUG-94 19940829 IMMUNE SYSTEM CATALYTIC RETRO - DIELS - ALDERASE TRANSITION STATE ANALOGUE COMPLEX MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 TSSQTIVHTNGNTYLE 7 KVSNRFS 9 FQGSHFPLA 5 NYGMS 16 SISYGGLIYYPDSIKG 10 GDSFLVWFTF crystal 2.00A 20.60% FAB 05-MAY-02 20020505 IMMUNE SYSTEM RETRO - DIELS - ALDERASE CATALYTIC ANTIBODY MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 TSSQTIVHTNGNTYLE 7 KVSNRFS 9 FQGSHFPLA 5 NYGMS 16 SISYGGLIYYPDSIKG 10 GDSFLVWFTF crystal 2.00A 21.00% FAB 06-MAY-02 20020506 IMMUNE SYSTEM RETRO - DIELS - ALDERASE CATALYTIC ANTIBODY: PRODUCT ANALOGUE MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 TSSQTIVHTNGNTYLE 7 KVSNRFS 9 FQGSHFPLA 5 NYGMS 16 SISYGGLIYYPDSIKG 10 GDSFLVWFTF crystal 2.30A 20.80% FAB 06-MAY-02 20020506 IMMUNE SYSTEM RETRO - DIELS - ALDERASE CATALYTIC ANTIBODY 9D9 MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 RSSQTIVHTNGNTYFE 7 KVSNRLS 9 FQGSHSPWT 5 TYGMS 16 SISYGGLLYFSDSVKG 10 GTSFVRYFDV crystal 2.40A 23.90% FAB 06-MAY-02 20020506 IMMUNOGLOBULIN STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K - 4 LIGHT CHAIN LEN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 1.95A 15.00% LC-dimer 17-JUL-96 19960717 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE ? ? ? MUS MUSCULUS 16 RSSQSLLHSDGNTYLH 7 KVSNRFS 8 SQTTHVPT 5 NYWME 19 EIRLKSNNYATHYAESVKG 9 GGAVGAMDY crystal 2.80A 22.30% FAB 18-JUL-02 20020718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE COMPLEXED WITH A TRISACCHARIDE A TRISACCHARIDE ? ? MUS MUSCULUS 16 RSSQSLLHSDGNTYLH 7 KVSNRFS 8 SQTTHVPT 5 NYWME 19 EIRLKSNNYATHYAESVKG 9 GGAVGAMDY crystal 2.30A 21.60% FAB 19-JUL-02 20020719 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE COMPLEXED WITH A PENTASACCHARIDE A PENTASACCHARIDE ? ? MUS MUSCULUS 16 RSSQSLLHSDGNTYLH 7 KVSNRFS 8 SQTTHVPT 5 NYWME 19 EIRLKSNNYATHYAESVKG 9 GGAVGAMDY crystal 2.50A 22.00% FAB 19-JUL-02 20020719 IMMUNOGLOBULIN SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN ? KAPPA IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 0 N/A 0 N/A 0 N/A NMR N/A N/A LC-dimer 16-SEP-93 19930916 IMMUNOGLOBULIN SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN ? KAPPA IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 0 N/A 0 N/A 0 N/A NMR N/A N/A LC-dimer 16-SEP-93 19930916 IMMUNOGLOBULIN CRYSTAL STRUCTURE TO 2.45 A RESOLUTION OF A MONOCLONAL FAB SPECIFIC FOR THE BRUCELLA A CELL WALL POLYSACCHARIDE ANTIGEN ? KAPPA IGG2 MUS MUSCULUS 11 RASQDIYNYLN 7 YTSRLHS 9 QQGNTLPFT 5 DYYMS 19 FIRNKADGYTTEYSASVKG 8 DPYGPAAY crystal 2.45A 21.50% FAB 14-JAN-92 19920114 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - GLN - D - PHE - L - HIS - D - PRO - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 20.40% LC-dimer 25-FEB-93 19930225 IMMUNE SYSTEM PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - GLN - D - PHE - L - HIS - D - PRO - NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.90% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - D - PHE - B - ALA - L - HIS - D - PRO - NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.00% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - GLN - D - PHE - L - HIS - D - PRO - B - ALA - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.10% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - GLN - D - PHE - L - HIS - D - PRO - B - ALA - B - ALA - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.40% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - GLN - D - PHE - L - HIS - D - PRO - B - ALA - B - ALA - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 25.20% LC-dimer 25-FEB-93 19930225 IMMUNE SYSTEM PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - D - PHE - L - HIS - D - PRO - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 17.70% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - D - PHE - L - HIS - D - PRO - NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.30% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - D - GLU - L - HIS - D - PRO - NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.90% LC-dimer 25-FEB-93 19930225 IMMUNE SYSTEM PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: N - ACETYL - D - HIS - L - PRO - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.90% LC-dimer 25-FEB-93 19930225 IMMUNE SYSTEM PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - D - HIS - L - PRO - NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.30% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION ? ? IGG1 HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 7 TILYYWS 16 YIYYSGSTYGNPSLKS 7 VPLVVNP crystal 3.20A 23.20% ? 25-FEB-93 19930225 IMMUNOGLOBULIN PHOSPHOCHOLINE BINDING IMMUNOGLOBULIN FAB MC / PC603. AN X - RAY DIFFRACTION STUDY AT 2.7 ANGSTROMS ? KAPPA IGA MUS MUSCULUS 17 KSSQSLLNSGNQKNFLA 7 GASTRES 9 QNDHSYPLT 5 DFYME 19 ASRNKGNKYTTEYSASVKG 11 NYYGSTWYFDV crystal 2.70A 22.50% FAB 09-JUL-84 19840709 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - HIS - D - PRO - NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 20.40% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - HIS - D - PRO - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 20.40% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N - ACETYL - L - GLN - D - PHE - L - HIS - D - PRO - OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.30% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY ? ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 3.50A 17.00% LC-dimer 09-MAY-89 19890509 COMPLEX (ANTIBODY / ANTIGEN) CRYSTAL STRUCTURE OF A CAMEL SINGLE - DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 2.50A 22.10% HC-dimer 06-JUN-96 19960606 IMMUNE SYSTEM ANTIBODY CATALYSIS OF A BIMOLECULAR CYCLOADDITION REACTION ? ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRYS 9 QQYNSYPYT 5 DHAIH 17 YISPGNGDIKYNEKFKG 5 EYLDY crystal 1.25A 15.30% FAB 08-AUG-02 20020808 IMMUNOGLOBULIN ANTI HIV1 PROTEASE FAB COMPLEX IMMUNOGLOBULIN ANTI HIV1 PROTEASE FAB COMPLEX ? IGG1 MUS MUSCULUS 15 RASESVDYYGKSFMN 7 AASNQGS 9 QQSKEVPWT 5 RFGMH 17 YISSGSSTIYYADTVKG 16 SGGIERYDGTYYVMDY crystal 2.60A 20.60% FAB 27-DEC-96 19961227 IMMUNOGLOBULIN STRUCTURE OF A SINGLE - CHAIN FV FRAGMENT COMPLEXED WITH A CARBOHYDRATE ANTIGEN AT 1.7 ANGSTROMS RESOLUTION A CARBOHYDRATE ANTIGEN AT 1.7 ANGSTROMS RESOLUTION LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWSNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 1.70A 16.60% FV 25-OCT-93 19931025 IMMUNOGLOBULIN HIGH RESOLUTION STRUCTURES OF ANTIBODY FAB FRAGMENT COMPLEXED WITH CELL - SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA CELL - SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.10A 16.00% FAB 25-OCT-93 19931025 IMMUNOGLOBULIN HIGH RESOLUTION STRUCTURES OF ANTIBODY FAB FRAGMENT COMPLEXED WITH CELL - SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA CELL - SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.10A 16.30% FAB 25-OCT-93 19931025 IMMUNOGLOBULIN THE SOLUTION STRUCTURE OF A TRISACCHARIDE - ANTIBODY COMPLEX: COMPARISON OF NMR MEASUREMENTS WITH A CRYSTAL STRUCTURE COMPARISON OF NMR MEASUREMENTS WITH A CRYSTAL STRUCTURE LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.10A 18.30% FAB 25-OCT-93 19931025 IMMUNOGLOBULIN RECOGNITION OF A CELL - SURFACE OLIGO - SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT ? LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.00A 18.50% FAB 25-OCT-93 19931025 IMMUNE SYSTEM THE STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6 - 164 AND A TRANSITION - STATE ANALOG OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6 - 164 AND A TRANSITION - STATE ANALOG ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 SNWIN 17 NIYPDSYRTNYNEKFKR 10 KHYSYDGVVY crystal 2.10A 21.80% FAB 19-AUG-02 20020819 IMMUNE SYSTEM ANTIBODY - ANTIGEN COMPLEX MOLECULE: PROTEIN L DOMAIN C; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 2.10A 19.70% FAB 20-AUG-02 20020820 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A CHIMERIC ALPHA1 INTEGRIN I - DOMAIN IN COMPLEX WITH THE FAB FRAGMENT OF A HUMANIZED NEUTRALIZING ANTIBODY MOLECULE: INTEGRIN ALPHA 1, (RESIDUES 169 - 360); FRAGMENT: ALPHA1 I - DOMAIN; SYNONYM: LAMININ AND COLLAGEN RECEPTOR, VLA - 1, CD49A; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVNHMF 7 LTSNLAS 9 QQWSGNPWT 5 RYTMS 16 TISGGGHTYYLDSVKG 10 GFGDGGYFDV crystal 2.80A 22.20% FAB 20-AUG-02 20020820 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS5 - 393 ? ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLN 7 RMSNLAS 9 MQHLEYPFT 0 17 NVYPGSSSTNYNEKFKN 2 PY crystal 1.95A 21.90% FAB 23-AUG-02 20020823 IMMUNOGLOBULIN IGG FAB FRAGMENT (CD25 - BINDING) ? KAPPA IGG HOMO SAPIENS 10 SASSSRSYMQ 7 DTSKLAS 7 HQRSSYT 5 RYWMH 17 AIYPGNSDTSYNQKFEG 8 DYGYYFDF crystal 2.60A 19.60% FAB 04-DEC-95 19951204 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS5 - 393 AND A TRANSITION - STATE ANALOG OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS5 - 393 AND A TRANSITION - STATE ANALOG ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLN 7 RMSNLAS 9 MQHLEYPFT 0 14 NVYPSTNYNEKFKN 5 KDFPY crystal 2.25A 20.00% FAB 27-AUG-02 20020827 IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6 - 126 ? ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 SNWIN 17 NIYPGSGYTNYNERFKS 10 KHYFYDGVVY crystal 1.75A 15.50% FAB 27-AUG-02 20020827 IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6 - 12 AND A TRANSITION - STATE ANALOG OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6 - 12 AND A TRANSITION - STATE ANALOG ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 NYWIN 17 NIYPGSSYTHYNEKFKN 7 KLGWFPY crystal 2.10A 17.80% FAB 28-AUG-02 20020828 IMMUNE SYSTEM 1.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6 - 12 ? ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 NYWIN 17 NIYPGSSYTHYNEKFKN 7 KLGWFPY crystal 1.22A 12.30% FAB 28-AUG-02 20020828 IMMUNE SYSTEM MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG - WHITE LYSOZYME ? KAPPA IGG1 MUS MUSCULUS 11 RASQSISNNLH 7 YVSQSSS 9 QQSNSWPRT 5 TYWIE 17 EILPGSGSTYYNEKFKG 7 GDGNYGY crystal 2.10A 18.10% FAB 08-MAR-95 19950308 COMPLEX (ANTIBODY / ANTIGEN) MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG - WHITE LYSOZYME COMPLEXED WITH LYSOZYME MOLECULE: HEN EGG WHITE LYSOZYME; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 RASQSISNNLH 7 YVSQSSS 9 QQSNSWPRT 5 TYWIE 17 EILPGSGSTYYNEKFKG 7 GDGNYGY crystal 2.50A 18.40% FAB 10-MAR-95 19950310 IMMUNE SYSTEM UNLIGANDED BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS ? KAPPA ? MUS MUSCULUS 16 RSSQALVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPRT 5 SYWLH 17 GIYPGNRDTRYTQRFKD 12 IYFDYADFIMDY crystal 2.50A 23.10% FAB 30-APR-99 19990430 IMMUNE SYSTEM THE THREE - DIMENSIONAL STRUCTURE OF AN ENGINEERED SCFV T84.66 DIMER OR DIABODY IN VL TO VH LINKAGE. IMMUNOGLOBULIN VARIABLE DOMAINS LINKED VL TO VH WITH (GGGSGGGG) ? ? MUS MUSCULUS 15 RAGESVDIFGVGFLH 7 RASNLES 9 QQTNEDPYT 7 IFGVGFL 19 IYRASNLESGIPVRFSGTG 26 GGGTKLEIKGGGSGGGGEVQLQQSGA crystal 2.60A 21.30% scFv 09-SEP-02 20020909 COMPLEX (IMMUNOGLOBULIN / PEPTIDE) BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS MOLECULE: PORA P1.16 PEPTIDE FLUORESCEIN CONJUGATE; FRAGMENT: APEX OF EXTRACELLULAR LOOP 4 (VR2) OF PORA, RESIDUES 180 - 187; SYNONYM: P1.16, AC - TKDTNNNLC (FLUORESCEIN) - NH2; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 16 RSSQALVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPRT 5 SYWLH 17 GIYPGNRDTRYTQRFKD 12 IYFDYADFIMDY crystal 2.60A 19.40% FAB 26-FEB-97 19970226 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE UNLIGANDED FV - FRAGMENT OF THE ANTI - CYTOCHROME C OXIDASE ANTIBODY 7E2 ? ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLGE 10 QHHYGTPPLT 5 SYTMS 17 SINNGGGRTYYPDTVKG 9 HEYYYAMDY crystal 1.28A 13.60% FV 16-SEP-02 20020916 IGG JEL 103 FAB FRAGMENT ? ? ? MOUSE (MUS MUSCULUS) 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 7 LRGYFDY crystal 2.40A 19.10% FAB 13-JUN-94 19940613 IMMUNOGLOBULIN PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB - MONONUCLEOTIDE COMPLEXES ES KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 7 LRGYFDY crystal 2.30A 19.50% FAB 13-JUN-94 19940613 IMMUNOGLOBULIN PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB - MONONUCLEOTIDE COMPLEXES ES KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 7 LRGYFDY crystal 2.30A 19.20% FAB 13-JUN-94 19940613 IMMUNOGLOBULIN PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB - MONONUCLEOTIDE COMPLEXES ES KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 7 LRGYFDY crystal 2.40A 18.40% FAB 13-JUN-94 19940613 IMMUNE SYSTEM MAZE ADDICTION ANTIDOTE MOLECULE: IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 RKYMG 17 AIFIDNGNTIYADSVQG 17 SSRWMDYSALTAKAYNS crystal 1.65A 21.80% HC-dimer 25-SEP-02 20020925 IMMUNE SYSTEM SINGLE CHAIN FV OF C219 HEAVY CHAIN V101L MUTANT IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE MOLECULE: P - GLYCOPROTEIN; FRAGMENT: ATP - BINDING DOMAIN (RESIDUES 1 - 13); ENGINEERED: YES KAPPA ? MUS MUSCULUS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDYSYPLT 5 DDFMH 17 RIDPANDNTKYAPKFQD 12 RELYSYYSPLDV crystal 1.78A 19.70% FV 26-SEP-02 20020926 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A BROADLY NEUTRALIZING ANTI - HIV - 1 ANTIBODY IN COMPLEX WITH A PEPTIDE MIMOTOPE MOLECULE: B2.1 PEPTIDE; ENGINEERED: YES ? IGG HOMO SAPIENS 12 RSSHSIRSRRVA 7 GVSNRAS 9 QVYGASSYT 5 NFVIH 17 WINPYNGNKEFSAKFQD 18 VGPYSWDDSPQDNYYMDV crystal 1.80A 22.00% ? 15-OCT-02 20021015 IMMUNE SYSTEM STRUCTURE OF SCFV 1696 AT ACIDIC PH ? KAPPA ? MUS MUSCULUS 16 CRSSQTIVHNNGNTYL 7 YKVSNRF 10 CFQGSHFPPT 5 DYSMH 17 WINTETDEPTFADDFKG 11 DRHDYGEIFTY crystal 1.70A 22.70% FV 02-NOV-02 20021102 TRANSFERASE / IMMUNE SYSTEM / DNA HIV - 1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST - TRANSLOCATION AZTMP - TERMINATED DNA (COMPLEX P) MOLECULE: REVERSE TRANSCRIPTASE; SYNONYM: HIV - 1 RT; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: P51; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.10A 25.50% FAB 07-NOV-02 20021107 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE IMMUNODOMINANT ANTIGENIC SITE ON HEPATITIS C VIRUS PROTEIN BOUND TO MAB 19D9D6 MOLECULE: GENOME POLYPROTEIN CAPSID PROTEIN C; SYNONYM: HCV CORE 13 - 40 PEPTIDE, CORE PROTEIN, P22; EC: 3.4.22. - , 3.4.21.98, 2.7.7.48; ENGINEERED: YES ? ? 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 2.34A 19.00% FAB 08-NOV-02 20021108 TRANSFERASE / IMMUNE SYSTEM / DNA HIV - 1 REVERSE TRANSCRIPTASE CROSSLINKED TO PRE - TRANSLOCATION AZTMP - TERMINATED DNA (COMPLEX N) MOLECULE: REVERSE TRANSCRIPTASE; SYNONYM: HIV - 1 RT; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: P51; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.00A 24.70% FAB 11-NOV-02 20021111 IMMUNE SYSTEM GERMLINE 7G12 WITH N - METHYLMESOPORPHYRIN ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 SYWMH 17 RIDPNSGGTKYNEKFKS 5 RDSDY crystal 1.80A 22.00% ? 15-NOV-02 20021115 TRANSFERASE CRYSTAL STRUCTURE OF EXTRACELLULAR DOMAIN OF HUMAN HER2 COMPLEXED WITH HERCEPTIN FAB MOLECULE: RECEPTOR PROTEIN - TYROSINE KINASE ERBB - 2; FRAGMENT: EXTRACELLULAR DOMAIN; SYNONYM: TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2; EC: 2.7.1.112; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.52A 22.50% FAB 21-NOV-02 20021121 IMMUNE SYSTEM IGG1 FAB FRAGMENT (83.1) COMPLEX WITH 16 - RESIDUE PEPTIDE (RESIDUES 304 - 321 OF HIV - 1 GP120 (MN ISOLATE) ) MOLECULE: PEPTIDE MP1; ENGINEERED: YES ? IGG1 MUS MUSCULUS 16 RSSQSLGHSSGNTYLH 7 KVSNRFS 9 FQTTHDPYT 5 SGYWN 16 YISKSGSAYYNPSLKS 5 DDFDI crystal 2.57A 28.80% FAB 27-NOV-02 20021127 IMMUNOGLOBULIN AN AUTOANTIBODY TO SINGLE - STRANDED DNA: COMPARISON OF THE THREE - DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE - FAB COMPLEX IMMUNOGLOBULIN AN AUTOANTIBODY TO SINGLE - STRANDED DNA: COMPARISON OF THE THREE - DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE - FAB COMPLEX KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPLT 5 TNAMN 19 RIRSKSNNYATYYADSVKD 10 DQTGTAWFAY crystal 2.00A 24.60% FAB 16-MAR-93 19930316 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 63 COMPLEXED WITH HEL MUTANT K96A MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; ALLERGEN GAL D 4; GAL D IV; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 1.80A 21.60% ? 04-DEC-02 20021204 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 63 COMPLEXED WITH HEL MUTANT K97A MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; ALLERGEN GAL D 4; GAL D IV; EC: 3.2.1.17; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 1.85A 22.90% ? 04-DEC-02 20021204 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY 2D12.5 FAB COMPLEXED WITH Y - DOTA Y - DOTA LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GNNNRPP 9 ALWYSNHWV 5 DYGVH 16 VIWSGGGTAYTAAFIS 11 RGSYPYNYFDV crystal 2.10A 20.90% FAB 04-DEC-02 20021204 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY 2D12.5 FAB COMPLEXED WITH GD - DOTA GD - DOTA LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GNNNRPP 9 ALWYSNHWV 5 DYGVH 16 VIWSGGGTAYTAAFIS 11 RGSYPYNYFDV crystal 2.25A 20.80% FAB 04-DEC-02 20021204 HYDROLASE (O - GLYCOSYL) REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE - NC41 FAB COMPLEX MOLECULE: INFLUENZA A SUBTYPE N9 NEURAMINIDASE; EC: 3.2.1.18; KAPPA IGG2 MUS MUSCULUS 11 KASQDVSTAVV 7 WASTRHI 9 QQHYSPPWT 5 NYGMN 17 WINTNTGEPTYGEEFKG 11 GEDNFGSLSDY crystal 2.50A 19.10% FAB 21-JAN-92 19920121 HYDROLASE (O - GLYCOSYL) CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE - ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE MOLECULE: INFLUENZA A SUBTYPE N9 NEURAMINIDASE; EC: 3.2.1.18; KAPPA IGG2 MUS MUSCULUS 11 KASQDVSTAVV 7 WASTRHI 9 QQHYSPPWT 5 NYGMN 17 WINTNTGEPTYGEEFKG 11 GEDNFGSLSDY crystal 2.50A 16.50% FAB 21-JAN-92 19920121 HYDROLASE (O - GLYCOSYL) CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE - ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE MOLECULE: INFLUENZA A SUBTYPE N9 NEURAMINIDASE; EC: 3.2.1.18; KAPPA IGG2 MUS MUSCULUS 11 KASQDVSTAVV 7 WASTRHI 9 QQHYSPPWT 5 NYGMN 17 WINTNTGEPTYGEEFKG 11 GEDNFGSLSDY crystal 2.50A 21.20% FAB 21-JAN-92 19920121 HYDROLASE (O - GLYCOSYL) REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE - NC41 FAB COMPLEX MOLECULE: INFLUENZA A SUBTYPE N9 NEURAMINIDASE; EC: 3.2.1.18; KAPPA IGG2 MUS MUSCULUS 11 KASQDVSTAVV 7 WASTRHI 9 QQHYSPPWT 5 NYGMN 17 WINTNTGEPTYGEEFKG 11 GEDNFGSLSDY crystal 2.90A 15.70% FAB 21-JAN-92 19920121 IMMUNE SYSTEM CATIONIC CYCLIZATION ANTIBODY 4C6 IN COMPLEX WITH BENZOIC ACID WITH BENZOIC ACID ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 1.30A 15.80% FAB 05-DEC-02 20021205 IMMUNE SYSTEM CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG WITH TRANSITION STATE ANALOG ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 2.45A 24.20% FAB 05-DEC-02 20021205 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTIBODY HYHEL - 8 COMPLEXED WITH ITS ANTIGEN LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; ALLERGEN GAL D 4; GAL D IV; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 RDYWS 16 YISFSGNTFYHPSLKS 5 WDGTY crystal 1.90A 20.60% FAB 09-DEC-02 20021209 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTIBODY HYHEL - 26 COMPLEXED WITH LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; ALLERGEN GAL D 4; GAL D IV; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WEMDY crystal 2.10A 20.80% FAB 09-DEC-02 20021209 COMPLEX (IMMUNORECEPTOR/IMMUNOGLOBULIN) AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY MOLECULE: N15 ALPHA-BETA T-CELL RECEPTOR; ENGINEERED: YES; ? ? CRICETIDAE SP. 11 SGDQLPKNFAY 7 MDNKRPS 11 LSSYGDNNDLV 5 DFWMY 19 RIKNIPNNYATEYADSVRG 9 AGRFDHFDY crystal 2.80A 24.30% FAB 04-AUG-97 19970804 IMMUNOGLOBULIN N1G9 (IGG1 - LAMBDA) FAB FRAGMENT COMPLEXED WITH (4 - HYDROXY - 3 - NITROPHENYL) ACETATE (4 - HYDROXY - 3 - NITROPHENYL) ACETATE LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.40A 19.60% FAB 23-JUN-95 19950623 IMMUNOGLOBULIN N1G9 (IGG1 - LAMBDA) FAB FRAGMENT ? LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.40A 19.40% FAB 23-JUN-95 19950623 IMMUNE SYSTEM CHIMERIC AFFINITY MATURED FAB 7G12 COMPLEXED WITH MESOPORPHYRIN MESOPORPHYRIN ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQNVGTPVA 7 SASNRYT 9 QQYSSYPLT 5 SYWMH 17 MIDPNSGGTKYNEKFKS 5 RDMDY crystal 2.60A 27.50% FAB 18-DEC-02 20021218 IMMUNE SYSTEM CHIMERIC GERMLINE FAB 7G12 WITH JEFFAMINE FRAGMENT BOUND ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 SYWMH 17 RIDPNSGGTKYNEKFKS 5 RDSDY crystal 1.80A 22.50% FAB 18-DEC-02 20021218 IMMUNE SYSTEM CHIMERIC MATURE FAB 7G12 - APO ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQNVGTPVA 7 SASNRYT 9 QQYSSYPLT 5 SYWMH 17 MIDPNSGGTKYNEKFKS 5 RDMDY crystal 2.20A 23.50% FAB 18-DEC-02 20021218 IMMUNE SYSTEM CHIMERIC GERMLINE FAB 7G12 - APO ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 SYWMH 17 RIDPNSGGTKYNEKFKS 5 RDSDY crystal 1.60A 20.70% FAB 18-DEC-02 20021218 IMMUNE SYSTEM COCAINE HYDROLYTIC ANTIBODY 15A10 ? ? ? MUS MUSCULUS 14 RSSTGTITSDNYAN 7 VNNARPP 9 ALWYSNHWV 5 DYNMY 17 YIDPSNGDTFYNQKFQG 7 GGGLFAF crystal 2.35A 19.90% ? 30-DEC-02 20021230 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FACTOR IX GLA DOMAIN IN COMPLEX OF AN INHIBITORY ANTIBODY, 10C12 MOLECULE: FACTOR IX; FRAGMENT: GLA DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSTSNIGNNYVS 7 DVSKRPS 11 AAWDDSLSEFL 5 TYAMH 17 IISYDGSKKYYADSVKG 11 ASIAAARVLDY crystal 2.20A 23.30% ? 06-JAN-03 20030106 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HCV MONOCLONAL ANTIBODY 19D9D6 ? ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 1.60A 18.10% ? 07-JAN-03 20030107 IMMUNOGLOBULIN FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV - 1 ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 CYGVH 16 VIWSGGDTDYNAAFIS 5 RGGDF crystal 2.90A 19.80% FAB 02-JUL-96 19960702 COMPLEX (HYDROLASE / IMMUNOGLOBULIN) N9 NEURAMINIDASE COMPLEXES WITH ANTIBODIES NC41 AND NC10: EMPIRICAL FREE - ENERGY CALCULATIONS CAPTURE SPECIFICITY TRENDS OBSERVED WITH MUTANT BINDING DATA MOLECULE: N9 NEURAMINIDASE; EC: 3.2.1.18; MUTATION: YES; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSNLHS 9 QQDFTLPFT 5 NYNMY 17 IFYPGNGDTSYNQKFKD 13 SGGSYRYDGGFDY crystal 3.00A 20.00% FAB 06-MAY-94 19940506 COMPLEX (HYDROLASE / IMMUNOGLOBULIN) THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY MOLECULE: N9 NEURAMINIDASE; EC: 3.2.1.18; MUTATION: YES; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSNLHS 9 QQDFTLPFT 5 NYNMY 17 IFYPGNGDTSYNQKFKD 13 SGGSYRYDGGFDY crystal 2.20A 21.00% FAB 17-JAN-95 19950117 COMPLEX (SINGLE - CHAIN ANTIBODY / ANTIGEN) COMPLEX BETWEEN NC10 ANTI - INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 15 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE MOLECULE: NEURAMINIDASE; FRAGMENT: RESIDUES 82 - 468; EC: 3.2.1.18; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSNLHS 9 QQDFTLPFT 5 NYNMY 17 IFYPGNGDTSYNQKFKD 13 SGGSYRYDGGFDY crystal 2.50A 22.00% ? 21-DEC-97 19971221 IMMUNOGLOBULIN TRIVALENT ANTIBODY FRAGMENT ? ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.00A 18.70% scFv 04-APR-97 19970404 COMPLEX (IMMUNOGLOBULIN / HYDROLASE) THE CRYSTAL STRUCTURE OF ANTIBODY N10 - STAPHYLOCOCCAL NUCLEASE COMPLEX AT 2.9 ANGSTROMS RESOLUTION MOLECULE: STAPHYLOCOCCAL NUCLEASE; SYNONYM: STAPHYLOCOCCAL NUCLEASE RIBONUCLEATE, (DEOXYRIBONUCLEATE) - 3' - NUCLEOTIDOHYDROLASE; EC: 3.1.31.1; ENGINEERED: YES KAPPA IGG MUS MUSCULUS 15 RASQSVSTSSFRYMH 7 YASNLES 9 QHSWEIPYT 6 SDYAWN 16 YITYSGTTSYNPSLKS 4 GNGD crystal 2.80A 19.50% FAB 06-JUN-95 19950606 IMMUNE SYSTEM MODEL OF MOUSE CRRY - IG DETERMINED BY SOLUTION SCATTERING, CURVE FITTING AND HOMOLOGY MODELLING ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_STRAIN: NS/0 PLASMACYTOMA CELLS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A SolutionScattering N/A N/A FC 30-JAN-03 20030130 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF IGE FC REVEALS AN ASYMMETRICALLY BENT CONFORMATION ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGE(ND); EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_CELL_LINE: MOUSE MYELOMA NS0; EXPRESSION_SYSTEM_VECTOR_TYPE: EUKARYOTIC; EXPRESSION_SYSTEM_VECTOR: PEE6 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 21.80% FC 06-SEP-02 20020906 COMPLEX (WILLEBRAND / IMMUNOGLOBULIN) CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH THE FUNCTION BLOCKING NMC - 4 FAB MOLECULE: VON WILLEBRAND FACTOR; FRAGMENT: A1 DOMAIN RESIDUES 507 - 702, OR GLYCOPROTEIN IBA (A\:ALPHA) BINDING DOMAIN; ENGINEERED: YES ? IGG1 MUS MUSCULUS 11 SASQDINKYLN 7 YTSSLHS 9 QQYEKLPWT 5 DYGVD 16 MIWGDGSTDYNSALKS 14 DPADYGNYDYALDY crystal 2.20A 20.10% FAB 18-DEC-97 19971218 IMMUNE SYSTEM FREE CONFORMATION AB1 OF THE IGE SPE - 7 ? ? IGE MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 5 SYWMH 17 RIDPNGGGTKYNEKFKS 11 MWYYGTYYFDY crystal 1.50A 15.96% FV 21-JAN-03 20030121 IMMUNE SYSTEM FV IGE SPE - 7 IN COMPLEX WITH ALIZARIN RED WITH ALIZARIN RED ? IGE MUS MUSCULUS 10 RAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 5 SYWMH 17 RIDPNGGGTKYNEKFKS 11 MWYYGTYYFDY crystal 2.22A 20.50% FV 21-JAN-03 20030121 IMMUNE SYSTEM FV STRUCTURE OF THE IGE SPE - 7 IN COMPLEX WITH DNP - SER (IMMUNISING HAPTEN) WITH DNP - SER (IMMUNISING HAPTEN) ? IGE MUS MUSCULUS 14 RSSTGAVTTSNYAN 6 GNNRAP 2 FC 5 SYWMH 17 RIDPNGGGTKYNEKFKS 11 MWYYGTYYFDY crystal 1.80A 22.60% FV 21-JAN-03 20030121 IMMUNE SYSTEM FV STRUCTURE OF THE IGE SPE - 7 IN COMPLEX WITH ACENAPHTHENEQUINONE WITH ACENAPHTHENEQUINONE ? IGE MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 5 SYWMH 17 RIDPNGGGTKYNLKFKS 11 MWYYGTYYFDY crystal 2.66A 23.80% FV 21-JAN-03 20030121 IMMUNE SYSTEM ANTIBODY MULTISPECIFICITY MEDIATED BY CONFORMATIONAL DIVERSITY ? ? ? MUS MUSCULUS 9 RSSTAVTAN 2 NR 2 AV 5 SYWMH 17 RIDPNGGGTKYNLKFKS 11 MWYYGTYYFDY crystal 2.66A 22.60% FV 21-JAN-03 20030121 IMMUNE SYSTEM IGE FV SPE7 COMPLEXED WITH A RECOMBINANT THIOREDOXIN MOLECULE: THIOREDOXIN 1; FRAGMENT: TRX - SHEAR3, RESIDUES 1 - 123; SYNONYM: TRX1, TRX, TRXA, TSNC, FIPA; ENGINEERED: YES ? IGE MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 5 SYWMH 17 RIDPNGGGTKYNEKFKS 11 MWYYGTYYFDY crystal 2.77A 20.80% FV 21-JAN-03 20030121 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FAB COMPLEX WHITH PLASMODIUM FALCIPARUM MSP1 - 19 MOLECULE: MAJOR MEROZOITE SURFACE PROTEIN; FRAGMENT: MSP1 - 19, RESIDUES 8 - 100; ENGINEERED: YES ? ? MUS MUSCULUS 12 TATSSLSSSYLH 7 TTSNLAS 9 HQFHHSPYT 5 TAGIQ 17 WINTHSGVPQYADDFKG 11 NYYRFDGGMDF crystal 2.90A 25.80% FAB 22-JAN-03 20030122 IMMUNE SYSTEM FREE CONFORMATION AB2 OF THE IGE SPE - 7 ? ? IGE MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 5 SYWMH 17 RIDPNGGGTKYNEKFKS 11 MWYYGTYYFDY crystal 2.00A 1345700.00% FV 11-FEB-03 20030211 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF HEL4, A SOLUBLE HUMAN VH ANTIBODY DOMAIN RESISTANT TO AGGREGATION ? ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 DEDMG 17 SIYGPSGSTYYADSVKG 11 ALEPLSEPLGF crystal 2.00A 18.20% HC-dimer 30-MAY-03 20030530 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF A CAMELISED HUMAN VH ? ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 4 SYAS 19 VSAVSGSGGSTYYADSVRG 12 EPRIPRPPSFDY crystal 1.80A 15.58% HC-dimer 02-AUG-03 20030802 IMMUNE SYSTEM FAB 2G12 UNLIGANDED ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.20A 22.70% FAB 24-FEB-03 20030224 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 2G12 BOUND TO MAN1 ->2MAN ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 1.75A 23.10% FAB 04-MAR-03 20030304 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 2G12 BOUND TO MAN9GLCNAC2 ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 3.00A 25.20% FAB 04-MAR-03 20030304 HYDROLASE COMPLEX OF HUMAN LYSOZYME WITH CAMELID VHH HL6 ANTIBODY FRAGMENT MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; EC: 3.2.1.17; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 2 SG 17 AIRSSDGTTYYADSVKG 15 TEVAGWPLDIGIYDY crystal 1.86A 19.70% HC-dimer 05-MAR-03 20030305 IMMUNOGLOBULIN OPG2 FAB FRAGMENT ? ? ? HOMO SAPIENS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPLT 5 SYGMS 17 AISGGGTYIHYPDSVKG 16 HPFYRYDGGNYYAMDH crystal 2.00A 16.00% FAB 28-APR-95 19950428 IMMUNE SYSTEM COMPLEX BETWEEN G0 VERSION OF AN FC BOUND TO A MINIMIZED VERSION OF PROTEIN A CALLED MINI - Z ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; SYNTHETIC: YES; OTHER_DETAILS: PHAGE OPTIMIZED SEQUENCE FROM THE B-DOMAIN OF PROTEIN A STAPHYLOCOCCUS AUREUS. PEPTIDE PREPARED USING N-FMOC CHEMISTRY ON WANG RESIN. 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 21.60% FC 10-MAR-03 20030310 IMMUNE SYSTEM G - 2 GLYCOVARIANT OF HUMAN IGG FC BOUND TO MINIMIZED VERSION OF PROTEIN A CALLED Z34C ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; SYNTHETIC: YES; OTHER_DETAILS: PHAGE OPTIMIZED SEQUENCE FROM THE B-DOMAIN OF PROTEIN A STAPHYLOCOCCUS AUREUS. PEPTIDE PREPARED USING FMOC CHEMISTRY AND WANG RESIN. 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 21.90% FC 11-MAR-03 20030311 MEMBRANE PROTEIN X - RAY STRUCTURE OF A VOLTAGE - DEPENDENT POTASSIUM CHANNEL IN COMPLEX WITH AN FAB MOLECULE: POTASSIUM CHANNEL; FRAGMENT: KVAP; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 12 RARSSVSSSYLH 7 STSNLAS 9 QQYSGNPWT 6 SLYAWN 16 YINYSGYTSYNPSLKS 9 GVDYFAMDY crystal 3.20A 25.30% FAB 14-MAR-03 20030314 MEMBRANE PROTEIN X - RAY STRUCTURE OF THE KVAP POTASSIUM CHANNEL VOLTAGE SENSOR IN COMPLEX WITH AN FAB MOLECULE: POTASSIUM CHANNEL; ENGINEERED: YES ? ? MUS MUSCULUS 12 TASSSVSSSYLH 7 STSNLAS 8 HQFHRSLT 6 NNYAWN 16 YINYSGTTSYNPSLKS 9 GYDYFAMDY crystal 1.90A 23.10% FAB 14-MAR-03 20030314 COMPLEX (IMMUNOGLOBULIN / LIPOPROTEIN) CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB MOLECULE: OUTER SURFACE PROTEIN A; SYNONYM: OSPA; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 KASEDIYSRLA 7 GATSLET 9 QQYWSPPPT 5 SGFWD 16 YIRYGGGTYYNPSLKS 12 SRDYYGSSGFAF crystal 1.95A 22.90% FAB 23-NOV-96 19961123 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL AND FAB COMPLEX MOLECULE: VOLTAGE - GATED CLC - TYPE CHLORIDE CHANNEL ERIC; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.51A 26.40% FAB 22-MAR-03 20030322 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL E148A MUTANT AND FAB COMPLEX MOLECULE: VOLTAGE - GATED CLC - TYPE CHLORIDE CHANNEL ERIC; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.00A 29.60% FAB 23-MAR-03 20030323 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL E148Q MUTANT AND FAB COMPLEX MOLECULE: VOLTAGE - GATED CLC - TYPE CHLORIDE CHANNEL ERIC; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.30A 29.40% FAB 23-MAR-03 20030323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FCARI BOUND TO IGA1 - FC ? ? IGA MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHA1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHINESE HAMSTER OVARY CELLS; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ5GS-MCS3; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCAR OR CD89; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_STRAIN: HIGH 5 INSECT CELLS; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PACGP67 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.10A 25.20% FC 27-MAR-03 20030327 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE ANALYSIS OF AN ANTI - LYSOZYME ANTIBODY MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YTSQSMS 9 QQSGSWPRT 5 TYWIE 17 EILPGSDSTYYNEKVKG 7 GDGFYVY crystal 2.00A 20.40% ? 15-APR-03 20030415 IMMUNE SYSTEM THREE - DIMENSIONAL STRUCTURE OF A SINGLE CHAIN FV FRAGMENT COMPLEXED WITH THE PEPTIDE GCN4 (7P - 14P) . MOLECULE: GCN4 (7P - 14P) PEPTIDE; ENGINEERED: YES LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAS 7 GTNNRAP 9 ALWYSNHWV 5 DYGVN 16 VIWGDGITDYNSALKS 5 GLFDY crystal 2.35A 21.90% FV 22-APR-03 20030422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SCFV AGAINST PEPTIDE GCN4 ? LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAS 7 GTNNRAP 9 ALWYSNHWV 5 DYGVN 16 VIWGDGITDYNSALKS 5 GLFDY crystal 2.80A 20.00% FV 23-APR-03 20030423 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI - SSDNA ANTIGEN - BINDING FRAGMENT (FAB) BOUND TO 4 - (2 - HYDROXYETHYL) PIPERAZINE - 1 - ETHANESULFONIC ACID (HEPES) ? ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GGYRPYYAMDY crystal 1.75A 19.70% FAB 02-MAY-03 20030502 OXIDOREDUCTASE HDBT INHIBITED YEAST CYTOCHROME BC1 COMPLEX MOLECULE: UBIQUINOL - CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN 2; EC: 1.10.2.2; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 2.50A 22.80% FV 06-MAY-03 20030506 IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE OF JTO2, A MUTANT OF THE NON - AMYLOIDOGENIC LAMBA6 LIGHT CHAIN, JTO ? LAMBDA ? HOMO SAPIENS 13 TRSSGNIASNYVQ 7 EDNQRPS 11 YCQSYDARNVV 0 N/A 0 N/A 0 N/A crystal 1.60A 25.30% LC-dimer 22-MAY-03 20030522 IMMUNOGLOBULIN MOLECULAR - REPLACEMENT STRUCTURE OF GUINEA PIG IGG1 P *FC (PRIME) REFINED AT 3.1 ANGSTROMS RESOLUTION ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: CAVIA PORCELLUS; ORGANISM_COMMON: DOMESTIC GUINEA PIG; ORGANISM_TAXID: 10141 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.12A 30.30% FC 28-OCT-81 19811028 IMMUNE SYSTEM MURINE 6A6 FAB IN COMPLEX WITH HUMANIZED ANTI - TISSUE FACTOR D3H44 FAB WITH HUMANIZED ANTI - TISSUE FACTOR D3H44 FAB ? ? MUS MUSCULUS 11 RASRDIKSYLN 7 YATSLAE 9 LQHGESPWT 5 GHLLN 17 LVHPHNGAITYNQKFKD 11 EDFRYHYSMDY crystal 2.50A 21.70% FAB 27-MAY-03 20030527 IMMUNE SYSTEM MYELIN OLIGODENDROCYTE GLYCOPROTEIN - (8 - 18C5) FAB - COMPLEX MOLECULE: MYELIN OLIGODENDROCYTE GLYCOPROTEIN; FRAGMENT: N - TERMINAL IG DOMAIN; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLNSGNQKNYLA 7 GASTRES 9 QNDHSYPLT 5 SFWIE 17 EILPGRGRTNYNEKFKG 9 GNTMVNMPY crystal 3.00A 25.00% FAB 06-JUN-03 20030606 IMMUNOGLOBULIN EVIDENCE FOR THE EXTENDED HELICAL NATURE OF POLYSACCHARIDE EPITOPES. THE 2.8 ANGSTROMS RESOLUTION STRUCTURE AND THERMODYNAMICS OF LIGAND BINDING OF AN ANTIGEN BINDING FRAGMENT SPECIFIC FOR ALPHA - (2 ->8) - POLYSIALIC ACID ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLY 7 RVSNRFS 9 FQGTHVPYT 5 DYYIH 17 WIYPGSGNTKYNEKFKG 8 GGKFAMDY crystal 2.80A 16.40% FAB 24-APR-95 19950424 IMMUNOGLOBULIN THE CRYSTAL STRUCTURE OF AN FAB FRAGMENT THAT BINDS TO THE MELANOMA - ASSOCIATED GD2 GANGLIOSIDE ? ? ? MUS MUSCULUS 10 SASSSVSNIH 7 STSTLAS 9 QQRSGYPFT 5 KYTMH 17 DINPNNGGTNYNQKFKG 5 KSFDY crystal 2.80A 20.40% FAB 03-MAR-97 19970303 IMMUNE SYSTEM CRYSTAL STRUCTURE OF JTOR68S ? LAMBDA ? HOMO SAPIENS 13 TRSSGNIDSNYVQ 7 EDNQRPS 11 YCQSYDARNVV 0 N/A 0 N/A 0 N/A crystal 1.90A 22.00% LC-dimer 30-JUN-03 20030630 IMMUNE SYSTEM STRUCTURAL BASIS OF PEPTIDE - CARBOHYDRATE MIMICRY IN AN ANTIBODY COMBINING SITE MOLECULE: OCTAPEPTIDE (MDWNMHAA); ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLLHSDGNTYLH 7 KVSNRFS 8 SQTTHVPT 5 NYWME 19 EIRLKSNNYATHYAESVKG 9 GGAVGAMDY crystal 1.80A 21.90% FAB 09-JUL-03 20030709 IMMUNE SYSTEM ANTI - MORPHINE ANTIBODY 9B1 UNLIGANDED FORM ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWSNNKLV 5 SYWIE 17 EILPGSGDTIFNEKFKG 10 WVLDYYGMDY crystal 1.60A 21.60% FAB 17-JUL-03 20030717 IMMUNE SYSTEM ANTI - MORPHINE ANTIBODY 9B1 COMPLEXED WITH MORPHINE MORPHINE ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWSNNKLV 5 SYWIE 17 EILPGSGDTIFNEKFKG 10 WVLDYYGMDY crystal 2.00A 19.40% FAB 17-JUL-03 20030717 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF ANTI - HIV - 1 FAB 447 - 52D IN COMPLEX WITH V3 PEPTIDE MOLECULE: GP120 V3 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSSSNIGNNYVL 7 GNNKRPS 12 ATWDSGLSADWV 5 DVWLN 19 RIKSRTDGGTTDYAASVKG 20 DGFIMIRGVSEDYYYYYMDV crystal 2.50A 25.00% FAB 21-JUL-03 20030721 IMMUNE SYSTEM ANTI - COCAINE ANTIBODY M82G2 COMPLEXED WITH COCAINE COCAINE ? ? MUS MUSCULUS 16 RSSKSLLHSNGYTYLH 7 RVSNLAS 9 MQHLEYPFT 5 DAWVD 19 EIRNKANNHATKYTESVKG 10 VPQLGRGFAY crystal 1.70A 21.80% FAB 15-AUG-03 20030815 IMMUNE SYSTEM S25 - 2 FAB UNLIGANDED 1 ? KAPPA ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.96A 22.80% FAB 25-AUG-03 20030825 IMMUNE SYSTEM S25 - 2 FAB UNLIGANDED 2 ? KAPPA ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 2.28A 21.60% FAB 25-AUG-03 20030825 IMMUNE SYSTEM S45 - 18 FAB UNLIGANDED ? KAPPA ? MUS MUSCULUS 17 KSSQSLLNSRTRKSYLA 7 WAATRES 8 KQSYNLRT 5 DYYMS 19 FIRNKPKGYTTEYSASVKG 13 DIYSFGSRDGMDY crystal 1.79A 22.00% FAB 25-AUG-03 20030825 IMMUNE SYSTEM S45 - 18 FAB PENTASACCHARIDE BISPHOSPHATE COMPLEX IMMUNE SYSTEM S45 - 18 FAB PENTASACCHARIDE BISPHOSPHATE COMPLEX KAPPA ? MUS MUSCULUS 17 KSSQSLLNSRTRKSYLA 7 WAATRES 8 KQSYNLRT 5 DYYMS 19 FIRNKPKGYTTEYSASVKG 13 DIYSFGSRDGMDY crystal 1.75A 21.20% FAB 26-AUG-03 20030826 IMMUNE SYSTEM CHANGE IN DIMERIZATION MODE BY REMOVAL OF A SINGLE UNSATISFIED POLAR RESIDUE ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 LQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 1.80A 19.30% LC-dimer 25-FEB-99 19990225 IMMUNOGLOBULIN FAB E8 (FABE8A) X - RAY STRUCTURE AT 2.26 ANGSTROM RESOLUTION ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 QHFWSTPWT 5 DTYMH 17 RIDPASGNTKYDPKFQD 8 YDYGNFDY crystal 2.26A 19.20% FAB 29-APR-98 19980429 IMMUNOGLOBULIN FAB E8B ANTIBODY, X - RAY STRUCTURE AT 2.37 ANGSTROMS RESOLUTION ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 QHFWSTPWT 5 DTYMH 17 RIDPASGNTKYDPKFQD 8 YDYGNFDY crystal 2.37A 19.40% FAB 01-MAY-98 19980501 IMMUNE SYSTEM CAMELID HEAVY CHAIN VARIABLE DOMAINS PROVIDE EFFICIENT COMBINING SITES TO HAPTENS ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 GHGHYGM 17 AAIRWSGKETWYKDSVK 17 ARPVRVADISLPVGFDY crystal 2.50A 21.00% HC-dimer 08-JUL-99 19990708 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY MOLECULE: PROTEIN (HEMAGGLUTININ (HA2 CHAIN) ); FRAGMENT: BROMELAIN DIGESTED; KAPPA IGG1 MUS MUSCULUS 16 RSSQTLVHSNGNTYLH 7 KVSNRFS 9 SQNTHVPYT 5 TYWMN 17 RIDPYDSETHYNQKFKD 13 FLQITTIIYGMDY crystal 2.80A 19.80% FAB 14-APR-99 19990414 IMMUNE SYSTEM TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT MOLECULE: GONADOTROPIN ALPHA SUBUNIT; SYNONYM: HCG; ? ? ESCHERICHIA COLI 15 RASESVDSYGNSFMQ 7 RASNLES 11 QQSDEYPYMYT 5 SYWMH 14 EINPTNGRTYYNEK 8 RYGNSFDY crystal 3.50A 26.00% FV 15-APR-99 19990415 VIRUS/VIRAL PROTEIN STRUCTURE OF THE COMPLEX OF AN FAB FRAGMENT OF A NEUTRALIZING ANTIBODY WITH FOOT AND MOUTH DISEASE VIRUS MOLECULE: VIRUS CAPSID PROTEIN; FRAGMENT: RESIDUES 1-132 AND 161-211 FROM VP1; ? ? MOL_ID: 4; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE 15 RASESVDSSGHSFMH 7 RASNLES 9 QQSNEVPLT 5 RCAMS 17 TISSGGTYTYYPDSVKG 11 REDGGDEGFAY High-resolution microscopy 30.00A 0.00% FAB 23-APR-99 19990423 IMMUNE SYSTEM FAB FRAGMENT (MN14C11.6) IN COMPLEX WITH A PEPTIDE ANTIGEN DERIVED FROM NEISSERIA MENINGITIDIS P1.7 SEROSUBTYPE ANTIGEN AND DOMAIN II FROM STREPTOCOCCAL PROTEIN G MOLECULE: MAJOR OUTER MEMBRANE PROTEIN P1.16; FRAGMENT: RESIDUES 4 - 13; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 TVSNRFS 8 SQSTHFPT 5 DYYMF 17 TISDGGAYTYYPDSVKG 10 DPLEYYGMDY crystal 1.95A 20.90% FAB 17-AUG-99 19990817 OXIDOREDUCTASE / IMMUNE SYSTEM CRYO - STRUCTURE OF THE PARACOCCUS DENITRIFICANS FOUR - SUBUNIT CYTOCHROME C OXIDASE IN THE COMPLETELY OXIDIZED STATE COMPLEXED WITH AN ANTIBODY FV FRAGMENT MOLECULE: CYTOCHROME C OXIDASE POLYPEPTIDE II; SYNONYM: CYTOCHROME AA3 SUBUNIT 2, OXIDASE AA (3) SUBUNIT 2; EC: 1.9.3.1; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLGE 10 QHHYGTPPLT 5 SYTMS 17 SINNGGGRTYYPDTVKG 9 HEYYYAMDY crystal 3.00A 23.50% FV 30-AUG-99 19990830 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A HUMAN MONOCLONAL IGM COLD AGGLUTININ ? KAPPA IGM HOMO SAPIENS 12 GASQSVSSNYLA 7 DASSRAT 9 QQYGSSPLT 5 DYYWS 16 EINHSGSTNYNPSLKS 12 PPHDTSGHYWNY crystal 2.83A 21.60% FAB 11-SEP-99 19990911 IMMUNE SYSTEM NMR STRUCTURE OF THE 0.5B ANTI - HIV ANTIBODY COMPLEX WITH THE GP120 V3 PEPTIDE MOLECULE: GP120; FRAGMENT: V3 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPFT 5 TYPIE 17 NFHPYSDDTNYNEKFKG 10 HYGSAYAMDY NMR N/A N/A FV 26-OCT-99 19991026 IMMUNOGLOBULIN MFE - 23 AN ANTI - CARCINOEMBRYONIC ANTIGEN SINGLE - CHAIN FV ANTIBODY ? ? ? MUS MUSCULUS 17 TASGFNIKDSYMHWLRQ 7 NGDTEYA 15 YYCNEGTPTGPYYFD 5 DSYMH 17 WIDPENGDTEYAPKFQG 26 GTPTGPYYFDYWGQGTTVTVSSGENV crystal 2.40A 20.50% scFv 11-NOV-99 19991111 IMMUNE SYSTEM KAPPA VARIABLE LIGHT CHAIN ? KAPPA ? HOMO SAPIENS 11 QASQDISDYLI 7 DASTLET 9 QQYDDLPYT 0 N/A 0 N/A 0 N/A crystal 2.06A 1000.00% LC-dimer 30-MAY-99 19990530 IMMUNE SYSTEM ANTI - COCAINE ANTIBODY M82G2 COMPLEXED WITH BENZOYLECGONINE BENZOYLECGONINE ? ? MUS MUSCULUS 16 RSSKSLLHSNGYTYLH 7 RVSNLAS 9 MQHLEYPFT 5 DAWVD 19 EIRNKANNHATKYTESVKG 10 VPQLGRGFAY crystal 1.81A 17.80% FAB 10-SEP-03 20030910 TRANSFERASE/IMMUNE SYSTEM/DNA CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COVALENTLY TETHERED TO DNA TEMPLATE-PRIMER SOLVED TO 2.8 ANGSTROMS MOLECULE: REVERSE TRANSCRIPTASE; FRAGMENT: HIV-1 RT; EC: 2.7.7.49; ENGINEERED: YES; OTHER_DETAILS: P66; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 2.80A 23.90% FAB 19-SEP-03 20030919 IMMUNE SYSTEM FAB FROM MURINE IGG3 KAPPA ? KAPPA IGG3 MUS MUSCULUS 11 RASQDIGNFLN 7 YTSRLQS 9 QQGKTLPYT 5 NFGMH 17 YISSGGSSINYADTVKG 13 GGTGTRSLYYFDY crystal 3.10A 24.50% FAB 05-NOV-98 19981105 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN RB+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.40A 21.70% FAB 02-OCT-03 20031002 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN HIGH CONCENTRATION OF TL+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 1.90A 20.80% FAB 02-OCT-03 20031002 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN LOW CONCENTRATION OF TL+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.80A 23.80% FAB 02-OCT-03 20031002 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN CS+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.41A 21.90% FAB 02-OCT-03 20031002 IMMUNE SYSTEM MODEL OF HUMAN IGA2 DETERMINED BY SOLUTION SCATTERING, CURVE FITTING AND HOMOLOGY MODELLING MOLECULE: HUMAN IGA2 (M1) LIGHT CHAIN; ENGINEERED: YES; ? IGA HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 6 TSYGLH 17 GWISAGTGNTKYSQKFR 26 RDPYGGGKSEFDYWGQGTLVTVSSAS SolutionScattering N/A N/A ? 17-OCT-03 20031017 IMMUNOGLOBULIN (PART) SEQUESTERS ANTIGENS THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE - JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION MOLECULE: BENCE - JONES PROTEIN REI (LIGHT CHAIN); ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDIIKYLN 7 EASNLQA 9 QQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 2.00A 0.00% LC-dimer 17-MAR-76 19760317 IMMUNE SYSTEM ANTI - COCAINE ANTIBODY M82G2 ? ? ? MUS MUSCULUS 16 RSSKSLLHSNGYTYLH 7 RVSNLAS 9 MQHLEYPFT 5 DAWVD 19 EIRNKANNHATKYTESVKG 10 VPQLGRGFAY crystal 2.09A 18.30% FAB 07-NOV-03 20031107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY HIV - 1 NEUTRALIZING FAB X5 AT 1.90 ANGSTROM RESOLUTION ? ? ? HOMO SAPIENS 12 RASQSVSSGSLA 7 GASTRAT 9 QQYGTSPYT 5 MYGFN 17 GIIPIFGTSNYAQKFRG 22 DFGPDWEDGDSYDGSGRGFFDF crystal 1.90A 22.40% FAB 14-NOV-03 20031114 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF THE CAMELID SINGLE DOMAIN ANTIBODY 1D2L19 IN COMPLEX WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 NYCMG 16 VIDSSGRTAYADSVKG 17 GWSSLGSCGTNRNRYNY crystal 1.85A 17.30% HC-dimer 17-NOV-03 20031117 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 14F7, A UNIQUE ANTI - TUMOR ANTIBODY SPECIFIC FOR N - GLYCOLYL GM3 ? ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNRWPLT 5 SYWIH 17 YIDPATAYTESNQKFKD 16 ESPRLRRGIYYYAMDY crystal 2.50A 18.10% FAB 17-NOV-03 20031117 IMMUNE SYSTEM ANTI - COCAINE ANTIBODY M82G2 COMPLEXED WITH NORBENZOYLECGONINE NORBENZOYLECGONINE ? ? MUS MUSCULUS 16 RSSKSLLHSNGYTYLH 7 RVSNLAS 9 MQHLEYPFT 5 DAWVD 19 EIRNKANNHATKYTESVKG 10 VPQLGRGFAY crystal 2.00A 18.30% FAB 18-NOV-03 20031118 IMMUNE SYSTEM ANTI - COCAINE ANTIBODY M82G2 COMPLEXED WITH META - OXYBENZOYLECGONINE META - OXYBENZOYLECGONINE ? ? MUS MUSCULUS 16 RSSKSLLHSNGYTYLH 7 RVSNLAS 9 MQHLEYPFT 5 DAWVD 19 EIRNKANNHATKYTESVKG 10 VPQLGRGFAY crystal 2.20A 17.20% FAB 18-NOV-03 20031118 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF THE CAMELID SINGLE DOMAIN ANTIBODY CAB - LYS2 IN COMPLEX WITH HEN EGG WHITE LYSOZYME ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; TISSUE: BLOOD LYMPHOCYTES; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6SU; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN06; MOL_ID: 2; ORGANISM_SCIENTIFIC: GALLUS GALLUS; ORGANISM_COMMON: CHICKEN; ORGANISM_TAXID: 9031; TISSUE: EGG WHITE 0 0 0 0 0 0 crystal 1.40A 22.00% VHH 19-NOV-03 20031119 IMMUNE SYSTEM STRUCTURE OF THE COMPLEX BETWEEN OSPB - CT AND BACTERICIDAL FAB - H6831 MOLECULE: OUTER SURFACE PROTEIN B; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQNINVWLN 7 MASNLHT 9 QQGQSFPLT 5 SSWMH 17 EIHPNSGNTHYNEKFKG 11 MRYGDYYAMDN crystal 2.60A 19.10% FAB 19-NOV-03 20031119 IMMUNOGLOBULIN STRUCTURES OF A MONOCLONAL ANTI - ICAM - 1 ANTIBODY R6.5 FRAGMENT AT 2.8 ANGSTROMS RESOLUTION ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNNYLH 7 KVSNRFS 9 SQSTHVPLT 5 DYAIH 17 VISAYSGDTNYNQKFKG 10 GGWLLLSFDY crystal 2.80A 18.80% FAB 16-DEC-94 19941216 IMMUNE SYSTEM CRYSTAL STRUCTURE (A) OF U.V. - IRRADIATED CATIONIC CYCLIZATION ANTIBODY 4C6 FAB AT PH 4.6 WITH A DATA SET COLLECTED IN - HOUSE. ? ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 2.50A 19.20% FAB 11-DEC-03 20031211 IMMUNE SYSTEM CRYSTAL STRUCTURE (B) OF U.V. - IRRADIATED CATIONIC CYCLIZATION ANTIBODY 4C6 FAB AT PH 4.6 WITH A DATA SET COLLECTED AT SSRL BEAMLINE 11 - 1. ? ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 1.75A 19.40% FAB 11-DEC-03 20031211 IMMUNE SYSTEM CRYSTAL STRUCTURE (C) OF NATIVE CATIONIC CYCLIZATION ANTIBODY 4C6 FAB AT PH 4.6 WITH A DATA SET COLLECTED AT SSRL BEAMLINE 9 - 1 ? ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 1.40A 16.60% FAB 11-DEC-03 20031211 IMMUNE SYSTEM CRYSTAL STRUCTURE (D) OF U.V. - IRRADIATED CATIONIC CYCLIZATION ANTIBODY 4C6 FAB AT PH 5.6 WITH A DATA SET COLLECTED AT SSRL BEAMLINE 11 - 1. ? ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 1.88A 20.60% FAB 11-DEC-03 20031211 IMMUNE SYSTEM CRYSTAL STRUCTURE (F) OF H2O2 - SOAKED CATIONIC CYCLIZATION ANTIBODY 4C6 FAB AT PH 8.5 WITH A DATA SET COLLECTED AT SSRL BEAMLINE 9 - 1. ? ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 1.48A 17.50% FAB 11-DEC-03 20031211 IMMUNE SYSTEM CRYSTAL STRUCTURE (G) OF NATIVE CATIONIC CYCLIZATION ANTIBODY 4C6 FAB AT PH 8.5 WITH A DATA SET COLLECTED AT APS BEAMLINE 19 - ID ? ? IGG2 MUS MUSCULUS 16 KSSQRLLNSNGKTFLN 7 LGTKLDS 9 WQGTHFPYT 6 SDFAWN 16 YINYSGFTSHNPSLKS 10 LLWYDGGAGS crystal 1.40A 16.10% FAB 11-DEC-03 20031211 IMMUNE SYSTEM CRYSTAL STRUCTURE (H) OF U.V. - IRRADIATED DIELS - ALDER ANTIBODY 13G5 FAB AT PH 8.0 WITH A DATA SET COLLECTED IN HOUSE. ? ? ? MUS MUSCULUS 16 RSSKSLLNSNGIIHMY 7 QMSKLAS 9 AQNLELPYT 5 NYWLG 17 DIYPGGVYTTNNEKFRG 10 AGGYYTGGDY crystal 1.86A 21.90% FAB 11-DEC-03 20031211 IMMUNE SYSTEM CRYSTAL STRUCTURE (I) OF NATIVE DIELS - ALDER ANTIBODY 13G5 FAB AT PH 8.0 WITH A DATA SET COLLECTED AT SSRL BEAMLINE 9 - 1. ? ? ? MUS MUSCULUS 16 RSSKSLLNSNGIIHMY 7 QMSKLAS 9 AQNLELPYT 5 NYWLG 17 DIYPGGVYTTNNEKFRG 10 AGGYYTGGDY crystal 1.50A 19.10% FAB 11-DEC-03 20031211 VIRUS / IMMUNE SYSTEM FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS MOLECULE: HUMAN RHINOVIRUS 14 COAT PROTEIN; ? ? MUS MUSCULUS 10 SATSSVNYMH 7 SSSNLAS 9 QQRSSYPIT 5 SFWVN 17 QIYPGDGDNKYNGKFKG 10 SGNYPYAMDY crystal 4.00A 21.20% FAB 05-SEP-96 19960905 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - HIV - 1 GP120 - REACTIVE ANTIBODY 48D ? ? ? HOMO SAPIENS 11 RASQDISTWLA 7 AASTLQS 8 QQANSFFT 5 DFYMY 17 LIDPEDADTMYAEKFRG 10 DPWELNAFNV crystal 2.00A 20.10% FAB 24-DEC-03 20031224 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - HIV - 1 GP120 - REACTIVE ANTIBODY 17B ? ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.30A 21.20% FAB 24-DEC-03 20031224 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY E51 ? ? ? HOMO SAPIENS 13 SGSSSNIGNNDVS 7 ENNERPS 11 GTWDSSLSAVV 5 SHAFS 17 GIIPIFGSSHYAQKFRG 25 NSIAGVAAAGDYADYDGGYYYDMDV crystal 1.70A 19.80% FAB 24-DEC-03 20031224 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120 REACTIVE ANTIBODY 412D ? ? ? HOMO SAPIENS 11 RASQSISNWLA 7 KASSLKS 9 QQHDSSPYT 5 NYAIN 17 GIIPIFNIAHYAQRFQG 21 PYPNDYNDYAPEEGMSWYFDL crystal 2.00A 20.10% FAB 24-DEC-03 20031224 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 47E FAB ? ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTSHT 5 SYAIS 17 GIIPVFGSANYAQKFQG 20 GGEDGDYLSDPFYYNHGMDV crystal 2.90A 23.30% FAB 24-DEC-03 20031224 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.20A 26.20% FAB 24-DEC-03 20031224 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.90A 20.50% FAB 24-DEC-03 20031224 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMANIZED FAB (HU3S193) IN COMPLEX WITH THE LEWIS Y TETRASACCHARIDE MURINE COMPLEMENTARITY DETERMINING REGIONS GRAFTED ONTO HUMAN FRAMEWORK AND CONSTANT SEQUENCES; ? ? MUS MUSCULUS, HOMO SAPIENS 16 RSSQRIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YMSNVGAITDYPDTVKG 10 GTRDGSWFAY crystal 1.90A 20.30% FAB 13-JAN-04 20040113 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX T75C MUTANT IN K+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.20A 22.20% FAB 20-JAN-04 20040120 IMMUNE SYSTEM FAB (LNKB - 2) OF MONOCLONAL ANTIBODY TO HUMAN INTERLEUKIN - 2, CRYSTAL STRUCTURE ? ? ? MUS MUSCULUS 16 ESSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPRT 6 SDYAWN 16 YITYSGSTGYNPSLKS 9 YDDYTWFTY crystal 2.70A 20.00% FAB 21-JAN-04 20040121 TRANSFERASE INSIGHTS INTO ERBB SIGNALING FROM THE STRUCTURE OF THE ERBB2 - PERTUZUMAB COMPLEX MOLECULE: RECEPTOR PROTEIN - TYROSINE KINASE ERBB - 2; FRAGMENT: EXTRACELLULAR DOMAIN (RESIDUES 23 - 646); SYNONYM: P185ERBB2, NEU PROTO - ONCOGENE, C - ERBB - 2, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2, MLN 19; EC: 2.7.1.112; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQRFKG 10 NLGPSFYFDY crystal 3.25A 22.70% FAB 29-JAN-04 20040129 MONOCLONAL ANTIBODY CRYSTAL STRUCTURE OF AN ANTI - HCG FAB ? ? ? MUS MUSCULUS 17 KSSQSLLYSSNQMNYLA 7 WASTRES 9 QQYHSYPFT 5 NYWMN 19 DIRLKSNNYATLYAESVKG 12 GAYYRYDYAMDY crystal 2.00A 18.00% FAB 08-APR-98 19980408 IMMUNE SYSTEM FAB MNAC13 ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 TTSNLAS 9 HQWSSYPWT 5 TYTMS 17 YISKGGGSTYYPDTVKG 14 GAMFGNDFKYPMDR crystal 1.78A 19.40% FAB 18-FEB-04 20040218 IMMUNE SYSTEM CONVERGENT SOLUTIONS TO VHH DOMAIN STABILIZATION FROM NATURAL AND IN VITRO EVOLUTION ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYDMG 17 AINWGSAGTYYASSVRG 9 GRIESWVTW crystal 1.90A 18.80% HC-dimer 26-FEB-04 20040226 ANTIBIOTIC THREE - DIMENSIONAL STRUCTURE OF A LLAMA VHH DOMAIN SWAPPING ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 0 16 TINSRGITNYADFVKG 6 HYFRSY crystal 1.94A 20.60% HC-dimer 04-MAR-04 20040304 IMMUNE SYSTEM THREE - DIMENSIONAL STRUCTURE OF A LLAMA VHH DOMAIN OE7 BINDING THE CELL WALL PROTEIN MALF1 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INDMG 16 AITSGGSTKYADSVKG 11 EDRHRIGTVGY crystal 2.20A 19.20% HC-dimer 04-MAR-04 20040304 COMPLEX (ANTIBODY / PEPTIDE EPITOPE) CRYSTAL STRUCTURE OF THE TUMOR SPECIFIC ANTIBODY SM3 COMPLEX WITH ITS PEPTIDE EPITOPE MOLECULE: PEPTIDE EPITOPE; ENGINEERED: YES; OTHER_DETAILS: ANTI - BREAST TUMOUR ANTIBODY SM3 AGAINST EPITHELIAL MUCIN MUC1 ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 NYWMN 19 EIRLKSNNYATHYAESVKG 6 VGQFAY crystal 1.95A 21.30% FAB 23-DEC-97 19971223 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE NURSE SHARK NEW ANTIGEN RECEPTOR (NAR) VARIABLE DOMAIN IN COMPLEX WITH LYSOZYME ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GALLUS GALLUS; ORGANISM_COMMON: CHICKEN; ORGANISM_TAXID: 9031; OTHER_DETAILS: HEN EGG WHITE; MOL_ID: 2; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: XL1-BLUE; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PIMS100 0 0 0 0 0 0 crystal 1.45A 19.70% NAR 17-MAR-04 20040317 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SINGLE - CHAIN FV FRAGMENT 1696 IN COMPLEX WITH THE EPITOPE PEPTIDE CORRESPONDING TO N - TERMINUS OF HIV - 2 PROTEASE MOLECULE: EPITOPE PEPTIDE CORRESPONDING TO N - TERMINUS OF HIV - 2 PROTEASE; ENGINEERED: YES; OTHER_DETAILS: OCTAPEPTIDE PQFSLWKR KAPPA IGG1 MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.89A 19.60% scFv 30-MAR-04 20040330 SIGNALING PROTEIN / ANTIBIOTIC CRYSTAL STRUCTURE OF CD3GAMMAEPSILON HETERODIMER IN COMPLEX WITH OKT3 FAB FRAGMENT MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD3 GAMMA / EPSILON CHAIN; FRAGMENT: CD3 EPSILON / GAMMA ECTO DOMAIN; SYNONYM: T - CELL SURFACE ANTIGEN T3 / LEU - 4 GAMMA / EPSILON CHAIN; ENGINEERED: YES; OTHER_DETAILS: THIS PROTEIN IS COMPOSED OF GAMMA AND EPSILON CHAINS WITH 26 RESIDUES LINKER ? ? MUS MUSCULUS 10 SASSSVSYMN 7 DTSKLAS 9 QQWSSNPFT 5 RYTMH 17 YINPSRGYTNYNQKFKD 10 YYDDHYCLDY crystal 2.10A 21.10% FAB 31-MAR-04 20040331 TRANSFERASE / ANTIBODY / DNA HIV - 1 REVERSE TRANSCRIPTASE CROSSLINKED TO TENOFOVIR TERMINATED TEMPLATE - PRIMER (COMPLEX P) MOLECULE: POL POLYPROTEIN; FRAGMENT: REVERSE TRANSCRIPTASE, P51 SUBUNIT; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.10A 25.60% FAB 07-APR-04 20040407 IMMUNE SYSTEM THREE DIMENSIONAL STRUCTURE OF A HUMANIZED ANTI - IFN - GAMMA FAB IN C2 SPACE GROUP THE SOURCE IS ENGINEERED HUMAN CONSTANT AND FRAMEWORK REGIONS WITH CDRS FROM MOUSE.; ? ? HOMO SAPIENS 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 3.00A 21.70% FAB 07-APR-04 20040407 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMAN VH DOMAIN ? ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 NSAMS 17 SISGSGGNTYSADSVKG 7 DWYGMDV crystal 1.50A 16.00% HC-dimer 21-APR-04 20040421 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF AN NNA7 FAB THAT RECOGNIZES AN N - TYPE BLOOD GROUP ANTIGEN ? ? ? MUS MUSCULUS 16 RSSQSLVHSSGNTYLH 7 KVSNRFS 9 FQGSHVPLT 6 TSYGVH 16 GVIWSGGSTDYNAAFI 11 RNRGYSYAMDS crystal 1.83A 20.40% FAB 22-APR-04 20040422 IMMUNE SYSTEM THREE DIMENSIONAL STRUCTURE OF A HUMANIZED ANTI - IFN - GAMMA FAB (HUZAF) IN P21 21 21 SPACE GROUP THE SOURCE IS ENGINEERED HUMAN CONSTANT AND FRAMEWORK REGIONS WITH CDRS FROM MOUSE; ? ? HOMO SAPIENS 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 2.00A 17.40% FAB 26-APR-04 20040426 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNLIGANDED ALDOLASE ANTIBODY 93F3 FAB ? KAPPA IGG1 MUS MUSCULUS 17 RSSQSLFNSRTRKNYLA 7 WASTRES 8 KQSYDLPT 5 DYGVS 16 VIWGDGSTYYASALKF 9 HTYGGPGDS crystal 2.50A 23.30% FAB 29-APR-04 20040429 IMMUNE SYSTEM THE STRUCTURE OF FAB WITH INTERMEDIATE AFFINITY FOR FLUORESCEIN. ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPWT 5 DYWMN 19 QIRNKPYNYETYYSDSVKG 7 YGYHGAY crystal 2.30A 20.40% FAB 05-MAY-04 20040505 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE NURSE SHARK NEW ANTIGEN RECEPTOR (NAR) VARIABLE DOMAIN IN COMPLEX WITH LYSOZYME ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GALLUS GALLUS; ORGANISM_COMMON: CHICKEN; ORGANISM_TAXID: 9031; TISSUE: HEN EGG WHITE; MOL_ID: 2; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: XL1-BLUE; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PIMS100 0 0 0 0 0 0 crystal 1.70A 19.50% NAR 07-MAY-04 20040507 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (ORTHORHOMBIC) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PET; EXPRESSION_SYSTEM_VECTOR: 28B 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.00A 22.60% FC 11-MAY-04 20040511 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (HEXAGONAL) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET-28B 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.50A 24.70% FC 11-MAY-04 20040511 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF AN ANTICHOLERA TOXIN PEPTIDE COMPLEX AT 2.3 ANGSTROMS MOLECULE: CHOLERA TOXIN PEPTIDE 3 (CTP3); ENGINEERED: YES ? IGG1 MUS MUSCULUS 16 KSSQSIVHSSGNTYFE 7 KVSNRFS 9 FQGSHIPFT 5 TYGMS 17 WINTYSGVPTYADDFKG 7 RSWYFDV crystal 2.30A 14.80% FAB 21-JUN-93 19930621 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING ANTI - HIV - 1 ANTIBODY 2F5 IN COMPLEX WITH A GP41 7MER EPITOPE MOLECULE: ENVELOPE GLYCOPROTEIN GP41; FRAGMENT: TRANSMEMBRANE GLYCOPROTEIN (RESIDUES 659 - 669); ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.00A 19.80% FAB 04-JUN-04 20040604 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING ANTI - HIV - 1 ANTIBODY 2F5 IN COMPLEX WITH A GP41 11MER EPITOPE MOLECULE: ENVELOPE GLYCOPROTEIN GP41; FRAGMENT: TRANSMEMBRANE GLYCOPROTEIN (RESIDUES 659 - 669); ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.10A 20.00% ? 04-JUN-04 20040604 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING ANTI - HIV - 1 ANTIBODY 2F5 IN COMPLEX WITH A GP41 17MER EPITOPE MOLECULE: ENVELOPE GLYCOPROTEIN GP41; FRAGMENT: TRANSMEMBRANE GLYCOPROTEIN (RESIDUES 653 - 659); ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.20A 18.30% ? 04-JUN-04 20040604 UNKNOWN FUNCTION OVINE RECOMBINANT PRP (114 - 234) , ARQ VARIANT IN COMPLEX WITH THE FAB OF THE VRQ14 ANTIBODY MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: OVPRP (114 - 234); SYNONYM: PRION PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSRLDS 9 WQGSHFPQT 6 NYGMNL 17 WINTFTGEPTYADDFKG 7 FTRGTDY crystal 2.56A 22.00% FAB 16-JUN-04 20040616 UNKNOWN FUNCTION / IMMUNE SYSTEM OVINE RECOMBINANT PRP (114 - 234) , VRQ VARIANT IN COMPLEX WITH THE FAB OF THE VRQ14 ANTIBODY MOLECULE: PRION PROTEIN; FRAGMENT: VRQ VARIANT, RESIDUES 127 - 228; SYNONYM: OVPRP; ENGINEERED: YES; ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSRLDS 9 WQGSHFPQT 6 NYGMNL 17 WINTFTGEPTYADDFKG 7 FTRGTDY crystal 2.55A 21.40% FAB 17-JUN-04 20040617 UNKNOWN FUNCTION / IMMUNE SYSTEM OVINE RECOMBINANT PRP (114 - 234) , ARR VARIANT IN COMPLEX WITH THE VRQ14 FAB FRAGMENT (IGG2A) MOLECULE: PRION PROTEIN; FRAGMENT: ARR VARIANT, RESIDUES 127 - 228; SYNONYM: OVPRP; ENGINEERED: YES; ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSRLDS 9 WQGSHFPQT 6 NYGMNL 17 WINTFTGEPTYADDFKG 7 FTRGTDY crystal 2.80A 22.20% FAB 17-JUN-04 20040617 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING HUMAN FAB 4E10 IN COMPLEX WITH A 13 - RESIDUE PEPTIDE CONTAINING THE 4E10 EPITOPE ON GP41 MOLECULE: ENVELOPE POLYPROTEIN GP160; FRAGMENT: TRANSMEMBRANE GLYCOPROTEIN; SYNONYM: GP41; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.20A 21.70% FAB 09-JUL-04 20040709 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB YADS1 COMPLEXED WITH H - VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF, H - VEGF; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQASYSSVA 7 AASYLYS 8 QSSASPAT 5 DDDIH 17 YIAPSYGYTDYADSVKG 13 SSDASYSYSAMDY crystal 2.60A 21.50% FAB 09-JUL-04 20040709 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB YADS2 COMPLEXED WITH H - VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF, H - VEGF; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSYAYAVA 7 DASYLYS 9 QQAYSSPDT 5 DYDIH 17 DIAPYAGATAYADSVKG 11 SSYAYYAAMDY crystal 2.80A 22.00% FAB 10-JUL-04 20040710 IMMUNE SYSTEM STRUCTURE OF A LLAMA VHH DOMAIN RAISED AGAINST A CARBAZOLE MOLECULE ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYAVG 19 VGYFGTRGGRTYYADSVKG 16 RMPYSGDYRSSGTYDY crystal 1.60A 22.10% HC-dimer 14-JUL-04 20040714 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING ANTI - HIV FAB F105 ? ? ? HOMO SAPIENS 12 RASQSVSSRYLA 7 GASSRAT 9 QQYDNSVCT 5 SHYWS 16 YIYYSGSTNYSPSLKS 15 GPVPAVFYGDYRLDP crystal 2.81A 21.00% FAB 29-JUL-04 20040729 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ALDKWAS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.10A 22.10% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDKWAN MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.00A 23.30% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDKWAG MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 22.90% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE LELDKWASL MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 21.50% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE DLDRWAS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.60A 22.30% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDKYAS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.40A 21.80% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDKFAS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.56A 20.50% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDKHAS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 3.02A 21.10% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ECDKWCS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 3.23A 21.20% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELEKWAS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 22.80% FAB 06-AUG-04 20040806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ANALOG ENDKW - [DAP] - S (CYCLIC) MOLECULE: GP41 PEPTIDE ANALOG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 22.60% FAB 09-AUG-04 20040809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ANALOG E - [DAP] - DKWQS (CYCLIC) MOLECULE: GP41 PEPTIDE ANALOG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 22.50% FAB 09-AUG-04 20040809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ANALOG EQDKW - [DAP] - S (CYCLIC) MOLECULE: GP41 PEPTIDE ANALOG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.37A 23.80% FAB 09-AUG-04 20040809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDHWAS MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 21.00% FAB 09-AUG-04 20040809 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT SFSF COMPLEXED WITH HEN EGG WHITE LYSOZYME COMPLEX MOLECULE: LYSOZYME C; SYNONYM: C - TYPE LYSOZYME, HEN EGG WHITE LYSOZYME; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSSFGSTFYNPSLKS 5 WDGDY crystal 1.90A 22.70% FV 28-FEB-03 20030228 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT SFSF COMPLEXED WITH TURKEY WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: C - TYPE LYSOZYME, HEN EGG WHITE LYSOZYME; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSSFGSTFYNPSLKS 5 WDGDY crystal 1.70A 14.90% FV 08-MAR-03 20030308 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY 19G2 WITH HAPTEN AT 100K ? ? ? MUS MUSCULUS 16 RSTKSLLHSNGITYLY 7 QMSNLAS 9 AQNLELPPT 5 RYIMS 16 SISSGGITYYPDSVAG 6 GQGRPY crystal 2.00A 24.80% ? 30-MAR-03 20030330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY 19G2 WITH SERA LIGAND ? ? ? MUS MUSCULUS 16 RSTKSLLHSNGITYLY 7 QMSNLAS 9 AQNLELPPT 5 RYIMS 16 SISSGGITYYPDSVAG 6 GQGRPY crystal 2.12A 26.40% ? 30-MAR-03 20030330 IMMUNOGLOBULIN STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ) ? KAPPA IGG1 HOMO SAPIENS 16 RSSQIIVHNNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YISQGGDITDYPDTVKG 10 GLDDGAWFAY crystal 2.50A 20.00% FAB 06-FEB-96 19960206 IMMUNE SYSTEM / BLOOD CLOTTING CRYSTAL STRUCTURE OF A HUMANIZED FAB FRAGMENT OF ANTI - TISSUE - FACTOR ANTIBODY IN COMPLEX WITH TISSUE FACTOR MOLECULE: TISSUE FACTOR; FRAGMENT: RESIDUES 606 - 810; SYNONYM: TF, COAGULATION FACTOR III, THROMBOPLASTIN, CD142 ANTIGEN, BLOOD COAGULATION FACTOR; ENGINEERED: YES ? IGG HOMO SAPIENS 11 KASQDIKSFLS 7 YATSLAD 9 LQHGESPYT 5 DYYMH 17 GNDPANGHSMYDPKFQG 8 DSGYAMDY crystal 2.10A 19.60% FAB 25-JUL-03 20030725 IMMUNE SYSTEM CATALYTIC ANTIBODY 21H3 WITH HAPTEN ? ? ? MUS MUSCULUS 11 CRASQEISGYL 7 YAGSTLD 10 CLQYASYPRT 5 SYLFQ 17 YIYPYNGGTRYNEKFRG 9 SSMSDPGAN crystal 1.80A 22.30% ? 23-SEP-03 20030923 IMMUNE SYSTEM CATALYTIC ANTIBODY 21H3 WITH ALCOHOL SUBSTRATE ? ? ? MUS MUSCULUS 11 CRASQEISGYL 7 YAGSTLD 10 CLQYASYPRT 5 SYLFQ 17 YIYPYNGGTRYNEKFRG 9 SSMSDPGAN crystal 1.60A 20.50% ? 23-SEP-03 20030923 IMMUNE SYSTEM CATALYTIC ANTIBODY 21H3 ? ? ? MUS MUSCULUS 11 CRASQEISGYL 7 YAGSTLD 10 CLQYASYPRT 5 SYLFQ 17 YIYPYNGGTRYNEKFRG 9 SSMSDPGAN crystal 1.80A 23.10% ? 23-SEP-03 20030923 ANTIBODY MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9 ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 CAASQNVGTNV 7 YSTSYRY 10 CQQYNIYPVT 5 DFTIY 17 GIDPHNGGGAYNQKFRV 8 FYGNFFDY crystal 2.67A 21.90% FAB 05-FEB-04 20040205 ANTIBODY MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9 ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQNVGTHVA 7 SASYRYS 9 QQYNLFPVT 5 DFNIY 17 GIDPHNGGPVYNQKFNG 8 FYGNFFDY crystal 2.79A 20.70% FAB 05-FEB-04 20040205 IMMUNE SYSTEM P1.2 SEROSUBTYPE ANTIGEN DERIVED FROM N. MENINGITIDIS PORA IN COMPLEX WITH FAB FRAGMENT MOLECULE: PROTEIN G - PRIME; FRAGMENT: RESIDUES 56 - 118 (DOMAIN II); ENGINEERED: YES; ? ? MUS MUSCULUS 11 LASQTIGTWLA 7 AATSLAD 9 QQLSSTPYT 5 NFGLN 17 WINTYTGESTYADDFKG 14 GFYYYGSRYFYFDY crystal 2.20A 22.50% FAB 12-FEB-04 20040212 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTIFLAVIVIRUS FAB4G2 ? ? ? MUS MUSCULUS 11 KASENVVTYVS 7 GASNRYT 9 GQGYSYPYT 5 EYTIH 17 GIDPNSGGTNYSPNFKG 10 IYHYDGYFDV crystal 2.00A 20.09% FAB 03-MAR-04 20040303 IMMUNE SYSTEM ANTI - LEWIS X FAB FRAGMENT UNCOMPLEXED ? KAPPA IGG MUS MUSCULUS 16 RSSKSLLYSNGITYLY 7 QMSNLAS 9 AQNLEVPWT 5 GYWMS 17 EINPDSSTINYTPSLKD 8 ETGTRFDY crystal 2.05A 19.80% FAB 05-MAR-04 20040305 IMMUNE SYSTEM ANTI - LEWIS X FAB FRAGMENT IN COMPLEX WITH LEWIS X WITH LEWIS X KAPPA IGG MUS MUSCULUS 16 RSSKSLLYSNGITYLY 7 QMSNLAS 9 AQNLEVPWT 5 GYWMS 17 EINPDSSTINYTPSLKD 8 ETGTRFDY crystal 1.80A 21.00% FAB 05-MAR-04 20040305 IMMUNE SYSTEM / CYTOKINE HUMAN THROMBOPOIETIN FUNCTIONAL DOMAIN COMPLEXED TO NEUTRALIZING ANTIBODY TN1 FAB MOLECULE: THROMBOPOIETIN; FRAGMENT: TPO FUNCTIONAL DOMAIN; SYNONYM: MEGAKARYOCYTE COLONY STIMULATING FACTOR, MYELOPROLIFERATIVE LEUKEMIA VIRUS ONCOGENE LIGAND, C - MPL LIGAND, ML, MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR, MGDF; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVSYMY 7 STSNLAS 9 QQRSGYPRT 5 DAWMD 19 EIRSKVNNHAIHYAESVKG 5 WSFLY crystal 2.51A 23.20% FAB 18-DEC-03 20031218 IMMUNE SYSTEM / CYTOKINE HUMAN THROMBOPOIETIN FUNCTIONAL DOMAIN COMPLEXED TO NEUTRALIZING ANTIBODY TN1 FAB MOLECULE: THROMBOPOIETIN; FRAGMENT: TPO FUNCTIONAL DOMAIN; SYNONYM: MEGAKARYOCYTE COLONY STIMULATING FACTOR, MYELOPROLIFERATIVE LEUKEMIA VIRUS ONCOGENE LIGAND, C - MPL LIGAND, ML, MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR, MGDF; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 10 SASSSVSYMY 7 STSNLAS 9 QQRSGYPRT 5 DAWMD 19 EIRSKVNNHAIHYAESVKG 5 WSFLY crystal 3.30A 17.40% FAB 18-DEC-03 20031218 IMMUNE SYSTEM STRUCTURE OF NEW ANTIGEN RECEPTOR VARIABLE DOMAIN FROM SHARKS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ORECTOLOBUS MACULATUS; ORGANISM_COMMON: SPOTTED WOBBEGONG; ORGANISM_TAXID: 168098; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PGC 0 0 0 0 0 0 crystal 2.82A 17.00% NAR 05-APR-04 20040405 IMMUNE SYSTEM STRUCTURE OF NEW ANTIGEN RECEPTOR VARIABLE DOMAIN FROM SHARKS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ORECTOLOBUS MACULATUS; ORGANISM_COMMON: SPOTTED WOBBEGONG; ORGANISM_TAXID: 168098; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PGC 0 0 0 0 0 0 crystal 2.18A 17.90% NAR 05-APR-04 20040405 IMMUNOGLOBULIN BOUND WATER MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN - ANTIBODY ASSOCIATION ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.80A 15.80% FV 03-DEC-93 19931203 IMMUNOGLOBULIN / HYDROLASE (O - GLYCOSYL) BOUND WATER MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN - ANTIBODY ASSOCIATION MOLECULE: HEN EGG WHITE LYSOZYME; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.80A 18.50% FV 03-DEC-93 19931203 IMMUNOGLOBULIN TR1.9 FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY ? KAPPA IGG1 HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 6 TSYGLH 17 GWISAGTGNTKYSQKFR 13 RDPYGGGKSEFDY crystal 2.00A 18.00% FAB 04-JAN-96 19960104 IMMUNOGLOBULIN VH - P8, NMR ? ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 SYAMS 19 VSAVSGSGGSTYYADSVKG 8 LKKYAFDY NMR N/A N/A HC-dimer 16-APR-96 19960416 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - TESTOSTERONE FAB IN COMPLEX WITH TESTOSTERONE WITH TESTOSTERONE ? ? MUS MUSCULUS 16 RSSEVIVTRNGYTPIE 7 KAYKRFP 9 FDGSTVPPK 5 RYALS 16 SIVSGGNTYYSGSVKG 10 AYYGYVGLVH crystal 2.15A 21.10% FAB 15-NOV-04 20041115 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HLA - A1:MAGE - A1 IN COMPLEX WITH FAB - HYB3 MOLECULE: BETA - 2 - MICROGLOBULIN; FRAGMENT: RESIDUES 21 - 119; SYNONYM: HDCMA22P; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNNIGSRSVH 7 DDSDRPS 11 QVWDSRTDHWV 5 DYAMH 17 GISWNSGSIGYADSVKG 13 GRGFHYYYYGMDI crystal 2.15A 18.60% FAB 27-AUG-04 20040827 ANTIBODY FAB FRAGMENT OF PLP - DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH PHOSPHOPYRIDOXYL - L - ALANINE WITH PHOSPHOPYRIDOXYL - L - ALANINE ? ? MUS MUSCULUS 10 SATSGVNYMH 7 STSNLAS 9 QQRSTYPFT 5 DYYMS 19 LIRNKANGYTKEYSASVKG 14 DKGSYGNYEAWFAY crystal 2.33A 22.34% FAB 09-NOV-04 20041109 IMMUNE SYSTEM PLP - DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH ITS HAPTEN WITH ITS HAPTEN ? ? MUS MUSCULUS 10 SATSGVNYMH 7 STSNLAS 9 QQRSTYPFT 5 DYYMS 19 LIRNKANGYTKEYSASVKG 14 DKGSYGNYEAWFAY crystal 2.50A 22.30% FAB 12-NOV-04 20041112 COMPLEX (ANTIBODY / ELECTRON TRANSPORT) IGG1 FAB FRAGMENT (OF E8 ANTIBODY) COMPLEXED WITH HORSE CYTOCHROME C AT 1.8 A RESOLUTION MOLECULE: CYTOCHROME C; SYNONYM: CYT C, ANTIGEN; OTHER_DETAILS: ELECTRON TRANSPORT PROTEIN WITH HEME KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 QHFWSTPWT 5 DTYMH 17 RIDPASGNTKYDPKFQD 8 YDYGNFDY crystal 1.80A 20.00% FAB 26-MAR-98 19980326 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF A HUMANIZED ANTIBODY FV 528 ? ? ? HOMO SAPIENS 16 RSSQNIVHNNGITYLE 7 KVSDRFS 9 FQGSHIPPT 5 SYWMH 17 NIYPGSGGTNYAEKFKN 9 SGGPYFFDY crystal 2.10A 27.30% FV 16-NOV-04 20041116 IMMUNOGLOBULIN COMPARISON OF CRYSTAL STRUCTURES OF TWO HOMOLOGOUS PROTEINS: STRUCTURAL ORIGIN OF ALTERED DOMAIN INTERACTIONS IN IMMUNOGLOBULIN LIGHT CHAIN DIMERS MOLECULE: BENCE - JONES PROTEIN MCG (LIGHT CHAIN); ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDITNYVN 7 GASILET 9 QQYDTLPLT 0 N/A 0 N/A 0 N/A crystal 1.90A 15.70% LC-dimer 08-JUN-94 19940608 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FV FRAGMENT COMPLEXED WITH DANSYL - LYSINE DANSYL - LYSINE ? IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPFT 5 DAWMD 19 EIRNKANNHATYYAESVKG 10 IYYHYPWFAY crystal 1.85A 21.60% FV 21-FEB-05 20050221 IMMUNE SYSTEM 4M5.3 ANTI - FLUORESCEIN SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.50A 19.30% scFv 24-AUG-04 20040824 IMMUNE SYSTEM COMPLEX HCV CORE - FAB 19D9D6 - PROTEIN L MUTANT (D55A,L57H,Y64W) IN SPACE GROUP P21 MOLECULE: PROTEIN L; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 3.50A 19.50% FAB 03-SEP-04 20040903 IMMUNE SYSTEM COMPLEX HCV CORE - FAB 19D9D6 - PROTEIN L MUTANT (D55A, L57H, Y64W) IN SPACE GROUP P21212 MOLECULE: PROTEIN L; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 3.05A 19.50% FAB 03-SEP-04 20040903 IMMUNE SYSTEM / DNA STRUCTURE OF FAB DNA - 1 COMPLEXED WITH DT3 MOLECULE: 5' - D ( *TP *TP *T) - 3'; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GGYRPYYAMDY crystal 2.30A 20.40% FAB 13-SEP-04 20040913 IMMUNE SYSTEM STRUCTURE OF LIGAND - FREE FAB DNA - 1 IN SPACE GROUP P65 ? ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GGYRPYYAMDY crystal 2.30A 21.00% FAB 13-SEP-04 20040913 IMMUNE SYSTEM STRUCTURE OF LIGAND - FREE FAB DNA - 1 IN SPACE GROUP P321 SOLVED FROM CRYSTALS WITH PERFECT HEMIHEDRAL TWINNING ? ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GGYRPYYAMDY crystal 2.50A 18.70% FAB 13-SEP-04 20040913 IMMUNE SYSTEM COMPLEX HCV CORE - FAB 19D9D6 - PROTEIN L MUTANT (H74C, Y64W) IN SPACE GROUP P21212 MOLECULE: PROTEIN L; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 2.60A 20.10% FAB 14-SEP-04 20040914 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF THE CDR2 GERMLINE REVERSION MUTANT OF CAB - LYS3 IN COMPLEX WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINSGGGSTYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 1.50A 20.10% HC-dimer 15-SEP-04 20040915 IMMUNE SYSTEM STRUCTURE FOR ANTIBODY HYHEL-63 Y33A MUTANT COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4-BETA-N-ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDAWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.10A 21.50% ? 17-SEP-04 20040917 IMMUNE SYSTEM STRUCTURE FOR ANTIBODY HYHEL-63 Y33V MUTANT COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4-BETA-N-ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDVWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.10A 23.50% ? 17-SEP-04 20040917 IMMUNE SYSTEM STRUCTURE FOR ANTIBODY HYHEL - 63 Y33I MUTANT COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 CRASQSISNNL 7 KYASQSI 10 CQQSNSWPYT 5 SDIWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.10A 25.00% ? 17-SEP-04 20040917 IMMUNE SYSTEM STRUCTURE FOR ANTIBODY HYHEL - 63 Y33L MUTANT COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 CRASQSISNNL 7 KYASQSI 10 CQQSNSWPYT 5 SDLWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.10A 25.20% ? 17-SEP-04 20040917 IMMUNE SYSTEM STRUCTURE FOR ANTIBODY HYHEL - 63 Y33F MUTANT COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDFWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.10A 22.30% ? 17-SEP-04 20040917 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - META I RHODOPSIN FAB FRAGMENT K42 - 41L MOLECULE: RHODOPSIN EPITOPE MIMETIC PEPTIDE; FRAGMENT: PHAGE DISPLAY CONSENSUS PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSKSLLHSNGITYLY 7 RMSNLAS 9 GQMLEHPLT 5 DYYIN 17 WIFPRNGNTKYNEKFKG 8 TVSYVMDY crystal 2.71A 23.30% FAB 17-SEP-04 20040917 MEMBRANE PROTEIN/IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN CD3-E/D DIMER IN COMPLEX WITH A UCHT1 SINGLE-CHAIN ANTIBODY FRAGMENT MOLECULE: T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN; FRAGMENT: ECTODOMAIN; SYNONYM: T-CELL SURFACE ANTIGEN T3/LEU-4 EPSILON CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDIRNYLN 7 YTSRLHS 9 QQGNTLPWT 5 GYTMN 17 LINPYKGVSTYNQKFKD 13 SGYYGDSDWYFDV crystal 1.90A 20.40% FV 22-SEP-04 20040922 IMMUNE SYSTEM CATALYTIC ELIMINATION ANTIBODY 34E4 IN COMPLEX WITH HAPTEN THE VARIABLE DOMAIN (RESIDUES 1 - 107) IS FROM A MURINE SOURCE AND THE CONSTANT DOMAIN (RESIDUES 108 - 214) IS FROM A HUMAN SOURCE.; ? ? MUS MUSCULUS, HOMO SAPIENS 14 RSSSGAVTTSNYAT 7 GTNKRAP 9 ALWNSNHLV 5 RYWMT 17 EINPDSRTINYMPSLKD 14 LDFDVYNHYYVLDY crystal 2.50A 20.40% FAB 15-NOV-04 20041115 IMMUNE SYSTEM FAB FRAGMENT OF CATALYTIC ELIMINATION ANTIBODY 34E4 E (H50) D MUTANT IN COMPLEX WITH HAPTEN THE VARIABLE DOMAIN (RESIDUES 1 - 107) IS FROM A MURINE SOURCE AND THE CONSTANT DOMAIN (108 - 214) IS FROM A HUMAN SOURCE; ? ? MUS MUSCULUS, HOMO SAPIENS 14 RSSSGAVTTSNYAT 7 GTNKRAP 9 ALWNSNHLV 5 RYWMT 17 DINPDSRTINYMPSLKD 14 LDFDVYNHYYVLDY crystal 2.80A 21.50% FAB 17-NOV-04 20041117 IMMUNE SYSTEM CABAN33 VHH FRAGMENT AGAINST VSG ? ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 4 CTTG 16 SISSPGTIYYQDSVKG 10 QCGVRSIREY crystal 1.60A 19.20% HC-dimer 22-DEC-04 20041222 IMMUNE SYSTEM CABAN33 - Y37V / E44G / R45L TRIPLE MUTANT ? ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PCTTG 16 SISSPGTIYYQDSVKG 8 QCRSIREY crystal 2.70A 24.60% HC-dimer 22-DEC-04 20041222 CATALYTIC ANTIBODY STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.3) ? ? IGG2 MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 1.90A 20.80% FAB 15-APR-97 19970415 CATALYTIC ANTIBODY STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4) TRANSITION STATE ANALOGUE; ? IGG1 MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLES 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGGTYYNEKFKG 15 WGFTTVRENYYAMDY crystal 3.10A 21.50% FAB 15-APR-97 19970415 CATALYTIC ANTIBODY STRUCTURE OF A CATALYTIC ANTIBODY, IGG2A FAB FRAGMENT (D2.5) TRANSITION STATE ANALOGUE; ? IGG2 MUS MUSCULUS 16 KSSQSLLYSNGKTYLS 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSSYYNVKFKG 14 WGFIPVREDYVLDY crystal 2.20A 20.40% FAB 15-APR-97 19970415 CATALYTIC ANTIBODY STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH SUBSTRATE ANALOGUE SUBSTRATE ANALOGUE ? IGG2 MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 2.00A 19.90% FAB 29-MAY-97 19970529 CATALYTIC ANTIBODY STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT REACTION PRODUCT ? IGG2 MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 2.00A 19.90% FAB 29-MAY-97 19970529 CATALYTIC ANTIBODY STRUCTURE OF IGG2A FAB FRAGMENT IG GAMMA - 2A CHAIN C REGION (D2.3); ? IGG2 MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 2.55A 18.10% FAB 29-MAY-97 19970529 IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 1.90A 20.40% ? 13-AUG-98 19980813 IMMUNE SYSTEM CATALYTIC ANTIBODY COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY COMPLEX ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 1.85A 21.20% ? 13-AUG-98 19980813 IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 2.10A 20.00% ? 13-AUG-98 19980813 IMMUNE SYSTEM / SIGNALING PROTEIN CRYSTAL STRUCTURE OF HUMAN CD28 IN COMPLEX WITH THE FAB FRAGMENT OF A MITOGENIC ANTIBODY (5.11A1) MOLECULE: T - CELL - SPECIFIC SURFACE GLYCOPROTEIN CD28; FRAGMENT: EXTRACELLULAR REGION; SYNONYM: TP44; ENGINEERED: YES ? ? MUS MUSCULUS 11 HASQNIYVWLN 7 KASNLHT 9 QQGQTYPYT 5 SYYIH 17 CIYPGNVNTNYNEKFKD 11 SHYGLDWNFDV crystal 2.70A 23.90% FAB 14-JAN-05 20050114 IMMUNE SYSTEM ANTI - HCV FAB 19D9D6 COMPLEXED WITH PROTEIN L (PPL) MUTANT A66W MOLECULE: PROTEIN L; SYNONYM: PPL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 2.60A 22.80% FAB 21-JAN-05 20050121 IMMUNE SYSTEM IDENTIFICATION OF KEY RESIDUES OF THE NC6.8 FAB ANTIBODY FRAGMENT BINDING TO SYNTHETIC SWEETENERS: CRYSTAL STRUCTURE OF NC6.8 CO - CRYSTALIZED WITH HIGH POTENCY SWEETENER COMPOUND SC45647 ? KAPPA ? MUS MUSCULUS 16 RPSQSLVHSNGNTYLH 7 RVSNRFS 9 SQGTHVPYT 5 EYWIE 17 EILPGSGRTNYREKFKG 7 GYSSMDY crystal 2.10A 21.60% FAB 24-JAN-05 20050124 IMMUNE SYSTEM IDENTIFICATION OF KEY RESIDUES OF THE NC6.8 FAB ANTIBODY FRAGMENT BINDING TO SYNTHETIC SWEETERNERS: CRYSTAL STRUCTURE OF NC6.8 CO - CRYSTALIZED WITH HIGH POTENCY SWEETENER COMPOUND SC45647 MOLECULE: IG GAMMA HEAVY CHAIN; ENGINEERED: YES ? ? MUS MUSCULUS 16 RPSQSLVHSNGNTYLH 7 RVSNRFS 9 SQGTHVPYT 5 FYWIE 17 EILPGSGRTNYREKFKG 7 GYSSMDY crystal 1.70A 20.80% FAB 24-JAN-05 20050124 IMMUNE SYSTEM STRUCTURE OF THE IMMUNODOMINANT EPITOPE DISPLAYED BY THE SURFACE ANTIGEN 1 (SAG1) OF TOXOPLASMA GONDII COMPLEXED TO A MONOCLONAL ANTIBODY MOLECULE: PROTEIN L; FRAGMENT: DOMAIN C *; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPYT 5 DYGMH 17 IISTYSGDASYNQKFKG 9 SSTWYYFDY crystal 3.10A 24.10% FAB 25-JAN-05 20050125 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF THE ANTIBODY FAB HYHEL5 COMPLEX WITH LYSOZYME AT 1.7A RESOLUTION MOLECULE: HEN EGG WHITE LYSOZYME; SYNONYM: 1,4-BETA-N-ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 ? IGG1 MUS MUSCULUS 10 SASSSVNYMY 7 DTSKLAS 8 QQWGRNPT 5 DYWIE 17 EILPGSGSTNYHERFKG 7 GNYDFDG crystal 1.70A 19.50% FAB 02-FEB-05 20050202 IMMUNE SYSTEM FAB FRAGMENT ? LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRGP 9 ALWYSNHWV 5 SYLMH 17 RIDPNNVVTKFNEKFKS 9 YAYCRPMDY crystal 3.00A 19.00% FAB 30-JAN-96 19960130 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT FROM THE MONOCLONAL ANTIBODY CETUXIMAB / ERBITUX / IMC - C225 ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.00A 22.40% FAB 24-FEB-05 20050224 IMMUNE SYSTEM / TRANSFERASE STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE EPIDERMAL GROWTH FACTOR RECEPTOR IN COMPLEX WITH THE FAB FRAGMENT OF CETUXIMAB / ERBITUX / IMC - C225 MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: UNP RESIDUES 25 - 642; SYNONYM: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.60A 24.20% FAB 24-FEB-05 20050224 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF CD4M33, A SCORPION - TOXIN MIMIC OF CD4, IN COMPLEX WITH HIV - 1 YU2 GP120 ENVELOPE GLYCOPROTEIN AND ANTI - HIV - 1 ANTIBODY 17B MOLECULE: CD4M33, SCORPION - TOXIN MIMIC OF CD4; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.75A 20.20% FAB 25-FEB-05 20050225 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF F23, A SCORPION - TOXIN MIMIC OF CD4, IN COMPLEX WITH HIV - 1 YU2 GP120 ENVELOPE GLYCOPROTEIN AND ANTI - HIV - 1 ANTIBODY 17B MOLECULE: F23, SCORPION - TOXIN MIMIC OF CD4; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.20A 20.90% FAB 25-FEB-05 20050225 UNKNOWN FUNCTION HUMANIZED CABAN33 AT ROOM TEMPERATURE ? ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PCTTG 16 SISSPGTIYYQDSVKG 8 QCGVIREY crystal 2.70A 23.30% HC-dimer 01-MAR-05 20050301 IMMUNE SYSTEM / CELL ADHESION CRYSTAL STRUCTURE OF COMPLEX BETWEEN PVS25 AND FAB FRAGMENT OF MALARIA TRANSMISSION BLOCKING ANTIBODY 2A8 MOLECULE: OOKINETE SURFACE PROTEIN PVS25; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVSYMN 7 DTSKLAS 9 QQWSSNPPT 5 SYWMH 17 MIHPHSGSTNYNEKFKS 6 GWDVAY crystal 3.30A 27.50% FAB 12-MAR-05 20050312 IMMUNE SYSTEM / SIGNALING PROTEIN THE CRYSTAL STRUCTURE OF THE YSD1 FAB BOUND TO DR5 MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; FRAGMENT: EXTRA - CELLULAR DOMAIN; SYNONYM: DEATH RECEPTOR 5, TNF - RELATED APOPTOSIS - INDUCING LIGAND RECEPTOR 2, TRAIL RECEPTOR - 2, TRAIL - R2, DR5; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 AASYLYS 8 QSSSSPYT 5 SYSIH 17 SISPYSGYTSYADSVKG 20 YSSYYSYYYSSSSYSYAMDY crystal 3.35A 23.00% FAB 05-APR-05 20050405 IMMUNE SYSTEM THE STRUCTURE OF AN ANTITUMOR CH2 - DOMAIN - DELETED HUMANIZED ANTIBODY ? ? IGG HOMO SAPIENS 17 KSSQSLLYSGNQKNYLA 7 WASARES 9 QQYYSYPLT 5 DHAIH 17 YFSPGNDDFKYNERFKG 6 SLNMAY crystal 2.80A 24.60% ? 05-APR-05 20050405 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - NGF AD11 FAB ? ? ? RATTUS NORVEGICUS 11 RASEDIYNALA 7 NTDTLHT 9 QHYFGYPRT 5 NNNVN 16 GVWAGGATDYNSALKS 14 DGGYSSSTLYAMDA crystal 1.70A 19.60% FAB 06-APR-05 20050406 IMMUNE SYSTEM STRUCTURE OF THE ANTI - CHOLERA TOXIN ANTIBODY FAB FRAGMENT TE33 IN COMPLEX WITH A D - PEPTIDE MOLECULE: SHORT SYNTHETIC D - AMINO ACID PEPTIDE D2; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 16 KSSQSIVHSSGNTYFE 7 KVSNRFS 9 FQGSHIPFT 5 TYGMS 17 WINTYSGVPTYADDFKG 7 RSWYFDV crystal 1.78A 19.80% FAB 18-APR-05 20050418 IMMUNE SYSTEM FAB 2G12 + MAN4 ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.00A 28.40% FAB 09-MAY-05 20050509 IMMUNE SYSTEM FAB 2G12 + MAN5 ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.75A 22.50% FAB 09-MAY-05 20050509 IMMUNE SYSTEM FAB 2G12 + MAN7 ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSdrLSDNDPFDA crystal 2.33A 21.20% FAB 09-MAY-05 20050509 IMMUNE SYSTEM FAB 2G12 + MAN8 ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.85A 22.40% FAB 09-MAY-05 20050509 IMMUNE SYSTEM / HYDROLASE CABBCII - 10 VHH FRAMEWORK WITH CDR LOOPS OF CABLYS3 GRAFTED ON IT AND IN COMPLEX WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; ALLERGEN GAL D 4; GAL D IV; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 3.00A 20.60% HC-dimer 11-MAY-05 20050511 VIRAL PROTEIN / IMMUNE SYSTEM WEST NILE VIRUS ENVELOPE PROTEIN DIII IN COMPLEX WITH NEUTRALIZING E16 ANTIBODY FAB MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III (RESIDUES 463 - 568); ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 WASTRHT 9 QQHYTTPLT 5 DYWIE 17 DILCGTGRTRYNEKLKA 10 SASYGDYADY crystal 2.50A 20.80% FAB 27-MAY-05 20050527 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE VARIABLE DOMAIN OF THE CAMELID HEAVY - CHAIN ANTIBODY D2 - L29 IN COMPLEX WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 NYCIG 17 FINSDGGITYYADSVKG 12 GYRNYGQCATRY crystal 2.00A 21.70% HC-dimer 01-JUN-05 20050601 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE VHH DOMAIN D2 - L24 IN COMPLEX WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 INYLG 19 VAAVSPAGGTPYYADSVKG 16 ARQGWYIPLNSYGYNY crystal 1.50A 20.80% HC-dimer 02-JUN-05 20050602 IMMUNE SYSTEM SEMI - EXTENDED SOLUTION STRUCTURE OF HUMAN MYELOMA IMMUNOGLOBULIN D DETERMINED BY CONSTRAINED X - RAY SCATTERING CONSISTS OF IG LAMBDA CHAIN V - I REGION WAH AND IG LAMBDA CHAIN C REGIONS; LAMBDA ? HOMO SAPIENS 13 FGSSSNIGRYYVY 7 KDNQRPS 9 AAWDDSLWV 7 RTGYYWG 16 GVYYTGSIYYNPSLRG 19 GNPPPYYDIGTGSDDGIDV SolutionScattering N/A N/A ? 02-JUN-05 20050602 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE VHH D3 - L11 IN COMPLEX WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 IEYMT 17 ALYTHTGNTYYTDSVKG 18 TRKYVPVRFALDQSSYDY crystal 1.63A 20.90% HC-dimer 03-JUN-05 20050603 IMMUNE SYSTEM / ION TRANSPORT STRUCTURE OF MUTANT KCSA POTASSIUM CHANNEL MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 22 - 123; SYNONYM: KCSA POTASSIUM CHANNEL; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.50A 24.30% ? 03-JUN-05 20050603 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 5C8, FAB - HAPTEN COMPLEX CATALYTIC ANTIBODY CATALYTIC ANTIBODY 5C8, FAB - HAPTEN COMPLEX ? IGG MUS MUSCULUS 12 TASSSVSSSNLH 7 STSNLAS 9 HQYHRSPYT 5 DTYMH 17 QIDPANGNTKYDPKFQG 10 DPPYYGHGDY crystal 2.00A 22.90% FAB 18-MAR-98 19980318 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF KVAP - 33H1 FV COMPLEX MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: KVAP K+ CHANNEL; SYNONYM: KVAP; ENGINEERED: YES; ? ? MUS MUSCULUS 12 TASSSVSSSYLH 7 STSNLAS 8 HQFHRSLT 6 NNYAWN 16 YINYSGTTSYNPSLKS 9 GYDYFAMDY crystal 3.90A 35.80% FV 16-JUN-05 20050616 IMMUNE SYSTEM ANTI - COCAINE ANTIBODY 7.5.21, CRYSTAL FORM I ? KAPPA ? MUS MUSCULUS 16 RCSQSIVKSNGHTYLE 7 KVSNRFS 9 FQGSHIPWT 5 NYGMS 17 AISGNSLYTSYPDSVKG 14 HDDYYGKSPYFFDV crystal 2.70A 18.80% FAB 21-JUN-05 20050621 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - ARSONATE GERMLINE ANTIBODY 36 - 65 IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE RLLIADPPSPRE MOLECULE: DODECAPEPTIDE, RLLIADPPSPRE; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPRT 5 SYGIN 17 YINPGNGYTKYNEKFKG 12 SVYYGGSYYFDY crystal 2.90A 23.00% FAB 02-JUL-05 20050702 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - ARSONATE GERMLINE ANTIBODY 36 - 65 IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE KLASIPTHTSPL MOLECULE: DODECAPEPTIDE: KLASIPTHTSPL; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPRT 5 SYGIN 17 YINPGNGYTKYNEKFKG 12 SVYYGGSYYFDY crystal 2.50A 24.50% FAB 02-JUL-05 20050702 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - ARSONATE GERMLINE ANTIBODY 36 - 65 ? ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPRT 5 SYGIN 17 YINPGNGYTKYNEKFKG 12 SVYYGGSYYFDY crystal 2.70A 22.50% FAB 02-JUL-05 20050702 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE GERMLINE ANTIBODY 36 - 65 FAB IN COMPLEX WITH THE DODECAPEPTIDE SLGDNLTNHNLR MOLECULE: DODECAPEPTIDE: SLGDNLTNHNLR; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPRT 5 SYGIN 17 YINPGNGYTKYNEKFKG 12 SVYYGGSYYFDY crystal 3.00A 24.50% FAB 03-JUL-05 20050703 IMMUNE SYSTEM ANTI-COCAINE ANTIBODY 7.5.21, CRYSTAL FORM II ? ? ? MUS MUSCULUS 16 RCSQSIVKSNGHTYLE 7 KVSNRFS 9 FQGSHIPWT 5 NYGMS 17 AISGNSLYTSYPDSVKG 13 HDDYGKSPYFFDV crystal 1.80A 26.30% ? 04-JUL-05 20050704 IMMUNE SYSTEM STRUCTURAL ANALYSIS OF A TIGHT - BINDING FLUORESCEIN - SCFV; APO FORM ? ? ? HOMO SAPIENS 13 SGSTSNIGNNYVS 7 DVSKRPS 11 AAWDDSLSEFL 5 SFSMS 17 GLSARSSLTHYADSVKG 18 RSYDSSGYWGHFYSYMDV crystal 2.10A 21.20% FV 12-JUL-05 20050712 IMMUNE SYSTEM A MUTATION DESIGNED TO ALTER CRYSTAL PACKING PERMITS STRUCTURAL ANALYSIS OF A TIGHT - BINDING FLUORESCEIN - SCFV COMPLEX IMMUNE SYSTEM A MUTATION DESIGNED TO ALTER CRYSTAL PACKING PERMITS STRUCTURAL ANALYSIS OF A TIGHT - BINDING FLUORESCEIN - SCFV COMPLEX ? ? HOMO SAPIENS 13 SGSTSNIGNNYVS 7 DVSKRPS 11 AAWDDSLSEFL 5 SFSMS 17 GLSARSSLTHYADSVKG 18 RSYDSSGYAGHFYSYMDV crystal 3.00A 22.10% FV 12-JUL-05 20050712 IMMUNE SYSTEM STRUCTURAL BASIS OF ANTIGEN MIMICRY IN A CLINICALLY RELEVANT MELANOMA ANTIGEN SYSTEM ? ? ? MUS MUSCULUS 15 RASESVEYYGSSLMQ 7 AASNVES 9 QQSRKIPYT 5 SFGMH 17 YISSDSSNIYYADTVKG 14 SNYVGYHVRWYFDV crystal 2.50A 23.60% FAB 13-JUL-05 20050713 BLOOD CLOTTING / IMMUNE SYSTEM CRYSTAL STRUCTURE AND PARATOPE DETERMINATION OF 82D6A3, AN ANTITHROMBOTIC ANTIBODY DIRECTED AGAINST THE VON WILLEBRAND FACTOR A3 - DOMAIN MOLECULE: VON WILLEBRAND FACTOR; FRAGMENT: A3 DOMAIN; SYNONYM: VWF; ENGINEERED: YES; ? IGG MUS MUSCULUS 11 KASQDINKYIA 7 YTSTLQP 8 LQYDNLRT 5 NYGMN 17 WKNTNTGETTYGEEFRG 9 DNPYYALDY crystal 1.90A 19.20% FAB 20-JUL-05 20050720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTI - CD4 ANTIBODY Q425 ? ? ? MUS MUSCULUS 11 ITSTDIDDDMN 7 EGNTLRP 9 LQSDTLPLT 5 SYGMS 17 TISSGGSYTYYPDNVKG 11 HEDGNWNYFDY crystal 2.50A 20.30% FAB 20-JUL-05 20050720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTI - CD4 ANTIBODY Q425 IN COMPLEX WITH BARIUM WITH BARIUM ? ? MUS MUSCULUS 11 ITSTDIDDDMN 7 EGNTLRP 9 LQSDTLPLT 5 SYGMS 17 TISSGGSYTYYPDNVKG 11 HEDGNWNYFDY crystal 2.80A 21.00% FAB 20-JUL-05 20050720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTI - CD4 ANTIBODY Q425 IN COMPLEX WITH CALCIUM WITH CALCIUM ? ? MUS MUSCULUS 11 ITSTDIDDDMN 7 EGNTLRP 9 LQSDTLPLT 5 SYGMS 17 TISSGGSYTYYPDNVKG 11 HEDGNWNYFDY crystal 2.90A 21.30% FAB 20-JUL-05 20050720 IMMUNE SYSTEM AN EPIDEMIOLOGICALLY SIGNIFICANT EPITOPE OF A 1998 INFLUENZA VIRUS NEURAMINIDASE FORMS A HIGHLY HYDRATED INTERFACE IN THE NA - ANTIBODY COMPLEX. MOLECULE: NEURAMINIDASE; EC: 3.2.1.18; ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRYS 9 QQFNRYPLT 5 DYYMS 19 LIRNKGNGYTMEYSASLKG 9 VDYGTNYDY crystal 2.10A 19.00% FAB 23-JUL-05 20050723 HYDROLASE / IMMUNE SYSTEM AN EPIDEMIOLOGICALLY SIGNIFICANT EPITOPE OF A 1998 INFLUENZA VIRUS NEURAMINIDASE FORMS A HIGHLY HYDRATED INTERFACE IN THE NA - ANTIBODY COMPLEX. MOLECULE: NEURAMINIDASE; EC: 3.2.1. -; ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRYS 9 QQFNRYPLT 5 DYYMS 19 LIRNKGNGYTMEYSASLKG 9 VDYGTNYDY crystal 3.00A 26.70% FAB 23-JUL-05 20050723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A GLYCOSYLATED FAB FROM AN IGM CRYOGLOBULIN WITH PROPERTIES OF A NATURAL PROTEOLYTIC ANTIBODY ? ? IGM HOMO SAPIENS 12 RASETVSNDKVA 7 GASSRAT 9 QQYASSPRT 7 TTGEGVG 16 FIYWNDAKRYNPSLQS 10 TSGWDIEFEY crystal 2.60A 21.90% FAB 27-JUL-05 20050727 IMMUNE SYSTEM ANTI-COCAINE ANTIBODY 7.5.21, CRYSTAL FORM III ? KAPPA ? MUS MUSCULUS 16 RCSQSIVKSNGHTYLE 7 KVSNRFS 9 FQGSHIPWT 5 NYGMS 17 AISGNSLYTSYPDSVKG 14 HDdyygkspyFFDV crystal 2.20A 27.90% ? 28-JUL-05 20050728 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A CROSS - REACTIVE HIV - 1 NEUTRALIZING CD4 - BINDING SITE ANTIBODY FAB M18 ? ? ? HOMO SAPIENS 11 RASQDIQKFLA 7 SASTLQS 9 QHLKRYPYT 5 NYYWT 16 NVYDSGDTNYNPSLSS 14 YHRHFIRGPLSFDY crystal 2.03A 22.50% FAB 01-AUG-05 20050801 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' IN COMPLEX WITH HEPTAETHYLENE GLYCOL WITH HEPTAETHYLENE GLYCOL KAPPA IGG1 MUS MUSCULUS 16 RSSRSLLYKDGRTYLN 7 LMSTRAS 9 QQFVEYPFT 6 TNYAWT 16 YIRSSVITRYNPSLKS 10 YDYYGNTGDY crystal 1.70A 20.90% FAB 02-AUG-05 20050802 IMMUNE SYSTEM CYRSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' ? KAPPA IGG1 MUS MUSCULUS 16 RSSRSLLYKDGRTYLN 7 LMSTRAS 9 QQFVEYPFT 6 TNYAWT 16 YIRSSVITRYNPSLKS 10 YDYYGNTGDY crystal 1.50A 18.40% FAB 02-AUG-05 20050802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' IN COMPLEX WITH COCAINE WITH COCAINE KAPPA IGG1 MUS MUSCULUS 16 RSSRSLLYKDGRTYLN 7 LMSTRAS 9 QQFVEYPFT 6 TNYAWT 16 YIRSSVITRYNPSLKS 10 YDYYGNTGDY crystal 1.50A 18.40% FAB 02-AUG-05 20050802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' IN COMPLEX WITH TRANSITION STATE ANALOG WITH TRANSITION STATE ANALOG KAPPA IGG1 MUS MUSCULUS 16 RSSRSLLYKDGRTYLN 7 LMSTRAS 9 QQFVEYPFT 6 TNYAWT 16 YIRSSVITRYNPSLKS 10 YDYYGNTGDY crystal 1.85A 22.70% FAB 02-AUG-05 20050802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' IN COMPLEX WITH ECGONINE METHYL ESTER AND BENZOIC ACID WITH ECGONINE METHYL ESTER AND BENZOIC ACID KAPPA IGG1 MUS MUSCULUS 16 RSSRSLLYKDGRTYLN 7 LMSTRAS 9 QQFVEYPFT 6 TNYAWT 16 YIRSSVITRYNPSLKS 10 YDYYGNTGDY crystal 2.10A 22.50% FAB 02-AUG-05 20050802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' IN COMPLEX WITH ECGONINE METHYL ESTER WITH ECGONINE METHYL ESTER KAPPA IGG1 MUS MUSCULUS 16 RSSRSLLYKDGRTYLN 7 LMSTRAS 9 QQFVEYPFT 6 TNYAWT 16 YIRSSVITRYNPSLKS 10 YDYYGNTGDY crystal 2.30A 23.80% FAB 02-AUG-05 20050802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COCAINE CATALYTIC ANTIBODY 7A1 FAB' IN COMPLEX WITH BENZOIC ACID WITH BENZOIC ACID KAPPA IGG1 MUS MUSCULUS 16 RSSRSLLYKDGRTYLN 7 LMSTRAS 9 QQFVEYPFT 6 TNYAWT 16 YIRSSVITRYNPSLKS 10 YDYYGNTGDY crystal 1.85A 21.70% FAB 02-AUG-05 20050802 IMMUNE SYSTEM SINGLE CHAIN FV OF C219 IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE MOLECULE: C-MYC TAG AND HIS TAG; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDYSYPLT 5 DDFMH 17 RIDPANDNTKYAPKFQD 12 REVYSYYSPLDV crystal 2.40A 22.10% FV 22-MAR-99 19990322 IMMUNE SYSTEM CD8ALPHA - ALPHA IN COMPLEX WITH YTS 105.18 FAB MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN; FRAGMENT: CD8ALPHA - ALPHA; SYNONYM: T - CELL SURFACE GLYCOPROTEIN LYT - 2; ENGINEERED: YES ? ? RATTUS NORVEGICUS 11 KASQNVRNNIA 7 YASYRYT 9 QRIYNSPYT 5 SNSVH 16 GIWGDGDTDYNSALKS 9 LIGSWYFDF crystal 2.88A 22.30% FAB 19-AUG-05 20050819 IMMUNE SYSTEM / ION TRANSPORT STRUCTURE OF A MUTANT KCSA K+ CHANNEL MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; SYNONYM: POTASSIUM CHANNEL KCSA; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.50A 23.80% FAB 25-AUG-05 20050825 IMMUNE SYSTEM COMPLEMENT RECEPTOR CHIMAERIC CONJUGATE CR2 - IG ? Kappa ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS, MUS MUSCULUS; ORGANISM_COMMON: HUMAN, HOUSE MOUSE; ORGANISM_TAXID: 9606,10090; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_CELL_LINE: NS/0 0 0 0 0 0 0 SolutionScattering N/A N/A Chimeric kappa 26-AUG-05 20050826 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF ANTI - HIV - 1 V3 FAB 2219 IN COMPLEX WITH MN PEPTIDE MOLECULE: MN PEPTIDE OF EXTERIOR MEMBRANE GLYCOPROTEIN GP120; FRAGMENT: RESIDUES 308 - 325; SYNONYM: GP120; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGTSSNVENNYVY 7 RNDHRSS 13 AAWDDSRGGPDWV 5 DYWIG 17 IFYPGDSDSRYSPSFEG 15 LGGDYEDSGADAFDF crystal 2.30A 21.90% FAB 14-SEP-05 20050914 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF ANTI - HIV - 1 V3 FAB 2219 IN COMPLEX WITH UG1033 PEPTIDE MOLECULE: UG1033 PEPTIDE OF EXTERIOR MEMBRANE GLYCOPROTEIN GP120; FRAGMENT: RESIDUES 31 - 53; SYNONYM: GP120; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGTSSNVENNYVY 7 RNDHRSS 13 AAWDDSRGGPDWV 5 DYWIG 17 IFYPGDSDSRYSPSFEG 15 LGGDYEDSGADAFDF crystal 2.35A 21.30% FAB 15-SEP-05 20050915 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF ANTI - HIV - 1 V3 FAB 2219 IN COMPLEX WITH UG29 PEPTIDE MOLECULE: UG29 PEPTIDE OF EXTERIOR MEMBRANE GLYCOPROTEIN GP120; FRAGMENT: RESIDUES 96 - 118; SYNONYM: GP120; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGTSSNVENNYVY 7 RNDHRSS 13 AAWDDSRGGPDWV 5 DYWIG 17 IFYPGDSDSRYSPSFEG 15 LGGDYEDSGADAFDF crystal 2.00A 20.60% FAB 15-SEP-05 20050915 IMMUNE SYSTEM VLA1 RDELTAH I - DOMAIN COMPLEXED WITH A QUADRUPLE MUTANT OF THE AQC2 FAB MOLECULE: INTEGRIN ALPHA - 1; FRAGMENT: I DOMAIN R DELTA H; SYNONYM: LAMININ AND COLLAGEN RECEPTOR, VLA - 1, CD49A; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSQVNHMF 7 LTSYLAS 9 QQWSGNPWT 5 RYTMS 16 VISGGGHTYYLDSVEG 10 GFGDGGYFDV crystal 2.20A 24.10% FAB 19-SEP-05 20050919 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 JR - FL GP120 CORE PROTEIN CONTAINING THE THIRD VARIABLE REGION (V3) COMPLEXED WITH CD4 AND THE X5 ANTIBODY MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSGSLA 7 GASTRAT 9 QQYGTSPYT 5 MYGFN 17 GIIPIFGTSNYAQKFRG 22 DFGPDWEDGDSYDGSGRGFFDF crystal 3.30A 31.90% ? 23-SEP-05 20050923 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN MCP - 1 BOUND TO A BLOCKING ANTIBODY, 11K2 MOLECULE: SMALL INDUCIBLE CYTOKINE A2; FRAGMENT: MONOCYTE CHEMOTACTIC PROTEIN - 1; SYNONYM: CCL2, MONOCYTE CHEMOTACTIC PROTEIN 1, MCP - 1, MONOCYTE CHEMOATTRACTANT PROTEIN 1, MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR, MCAF, MONOCYTE SECRETORY PROTEIN JE, HC11; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KATEDIYNRLA 7 GATSLET 9 QQFWSAPYT 5 DTYMH 17 RIDPANGNTKFDPKFQG 8 GVFGFFDY crystal 2.53A 22.00% FAB 20-OCT-05 20051020 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI ? ? ? MUS MUSCULUS 16 RSSQSLVSNNRRNYLH 7 KVSNRFS 9 SQSSHVPLT 5 TYYMS 17 AINSDGEPIYYPDTLKG 10 LNYAVYGMDY crystal 2.50A 18.70% FV 27-MAY-97 19970527 IMMUNE SYSTEM SPE7:ANTHRONE COMPLEX MOLECULE: IGE SPE7 LIGHT CHAIN; FRAGMENT: LIGHT CHAIN, RESIDUES 1 - 110; ENGINEERED: YES; ? IGE MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 5 SYWMH 17 RIDPNGGGTKYNEKFKS 11 MWYYGTYYFDY crystal 2.15A 26.90% ? 04-FEB-05 20050204 IMMUNE SYSTEM FAB FRAGMENT OF PLP - DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH PHOSPHOPYRIDOXYL - D - ALANINE WITH PHOSPHOPYRIDOXYL - D - ALANINE ? ? MUS MUSCULUS 10 SATSGVNYMH 7 STSNLAS 9 QQRSTYPFT 5 DYYMS 19 LIRNKANGYTKEYSASVKG 14 DKGSYGNYEAWFAY crystal 2.30A 20.97% FAB 14-MAR-05 20050314 IMMUNE SYSTEM / TRANSPORT PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA) MOLECULE: POTASSIUM CHANNEL KCSA; FRAGMENT: RESIDUES 1 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.76A 22.20% FAB 09-APR-05 20050409 IMMUNE SYSTEM / TRANSPORT PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS) MOLECULE: POTASSIUM CHANNEL KCSA; FRAGMENT: RESIDUES 1 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.01A 22.30% FAB 09-APR-05 20050409 IMMUNE SYSTEM COMPLEX OF THE NEISSERIAL PORA P1.4 EPITOPE PEPTIDE AND TWO FAB - FRAGMENTS (ANTIBODY MN20B9.34) MOLECULE: CLASS 1 OUTER MEMBRANE PROTEIN VARIABLE REGION 2; FRAGMENT: EXTRACELLULAR LOOP 4 OF PORA SUBTYPE P1.4, RESIDUES 16 - 26; OTHER_DETAILS: N - TERMINUS ACETYLATED, C - TERMINUS AMIDATED ? ? MUS MUSCULUS 12 RASSSVSSSYLH 7 STSNLAS 9 QQYSGYPYT 5 NYGMN 17 WINTYTGEPTYADDFKE 14 DYYGSTYPYYAMDY crystal 1.95A 20.00% FAB 11-MAY-05 20050511 RECEPTOR STRUCTURE OF LACTOCOCCAL BACTERIOPHAGE P2 RECEPTOR BINDING PROTEIN IN COMPLEX WITH A LLAMA VHH DOMAIN MOLECULE: RECEPTOR BINDING PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NWCMG 17 ALNFDYDMTYYADSVKG 14 RSGGFSSNRELYDG crystal 2.70A 25.30% HC-dimer 20-MAY-05 20050520 IMMUNE SYSTEM IS FR1 THE ANTIBODY'S ACHILLIES HEEL MOLECULE: VD9 VKI LIGHT - CHAIN; FRAGMENT: LIGHT - CHAIN VARIABLE DOMAIN, RESIDUES 1 - 107; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPNT 0 N/A 0 N/A 0 N/A crystal 2.70A 25.00% LC-dimer 22-JUL-05 20050722 IMMUNE SYSTEM ENAIIHIS FAB FRAGMENT IN THE FREE FORM ? ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGSHFPPT 5 NYWMN 17 MIHPSDSETRLNQKFKD 7 DDYDGAF crystal 2.75A 21.84% FAB 19-SEP-05 20050919 IMMUNE SYSTEM FAB - FRAGMENT OF ENANTIOSELECTIVE ANTIBODY COMPLEXED WITH FINROZOLE FINROZOLE ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGSHFPPT 5 NYWMN 17 MIHPSDSETRLNQKFKD 7 DDYDGAF crystal 2.00A 23.02% FAB 19-SEP-05 20050919 IMMUNE SYSTEM STRUCTURE OF HUMAN LAMBDA - 6 LIGHT CHAIN DIMER WIL ? LAMBDA ? HOMO SAPIENS 13 TRSSGSIANNYVH 7 EDDHRPS 11 YCQSYDHNNQV 0 N/A 0 N/A 0 N/A crystal 1.80A 28.90% LC-dimer 08-MAR-99 19990308 IMMUNOGLOBULIN LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI - SWEETENER FAB ATION OF AN ANTI - SWEETENER FAB KAPPA IGG2 MUS MUSCULUS 16 RPSQSLVHSNGNTYLH 7 RVSNRFS 9 SQGTHVPYT 5 EYWIE 17 EILPGSGRTNYREKFKG 7 GYSSMDY crystal 2.20A 21.40% FAB 23-NOV-93 19931123 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE TEPC15 - VK45.1 ANTI - 2 - PHENYL - 5 - OXAZOLONE NQ16 - 113.8 SCFV IN COMPLEX WITH PHOXGABA WITH PHOXGABA ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 NYYMN 19 SIRNKANGYTTDYSASVKG 10 GYGYGAWFAY crystal 2.50A 24.10% FV 09-APR-06 20060409 IMMUNOGLOBULIN ANTI - ANTI - IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, COMPLEX WITH A SYNTHETIC CYCLIC PEPTIDE MOLECULE: PROTEIN (11 - MER; CYCLIC PEPTIDE); OTHER_DETAILS: SYNTHETIC KAPPA IGG1 MUS MUSCULUS 17 KSSQNLLHSITRKNYLA 7 WASTRGS 8 KQSYNLYT 5 TDAMN 19 RIRSKGFNFATYYADSVRD 9 GRDGEAMDY crystal 2.20A 20.00% FAB 13-JUN-99 19990613 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 NEUTRALIZING ANTIBODY D5 FAB BOUND TO THE GP41 INNER - CORE MIMETIC 5 - HELIX MOLECULE: TRANSMEMBRANE GLYCOPROTEIN; FRAGMENT: 5 - HELIX, RESIDUES 543 - 582 AND 625 - 662; SYNONYM: GP41; ENGINEERED: YES; OTHER_DETAILS: SEQUENCE DERIVED FROM GENBANK P04578 WHERE THREE REGIONS EACH EQUIVALENT TO AA 543 - 582 ARE INTERSPERSED BY TWO DIFFERENT REGIONS (EACH EQUIVALENT TO AA 625 - 662) . LINKERS GGSGG AND GSSGG JOIN THE REGIONS AND ALTERNATE STARTING WITH GGSGG. A METHIONINE INITIATES AND A TAIL CONTAINS GGHHHHHHG ? ? HOMO SAPIENS 11 RASEGIYHWLA 7 KASSLAS 9 QQYSNYPLT 5 SYAIS 17 GIIPIFGTANYAQAFQG 10 DNPTLLGSDY crystal 2.00A 21.20% FAB 11-MAY-06 20060511 IMMUNE SYSTEM STRUCTURE OF NEW ANTIGEN RECEPTOR VARIABLE DOMAIN FROM SHARKS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ORECTOLOBUS MACULATUS; ORGANISM_COMMON: SPOTTED WOBBEGONG; ORGANISM_TAXID: 168098; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: TG1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PGC Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.10A 22.00% NAR 18-MAY-05 20050518 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE G91S MUTANT OF THE NNA7 FAB ? ? ? MUS MUSCULUS 16 RSSQSLVHSSGNTYLH 7 KVSNRFS 9 FQSSHVPLT 5 SYGVH 16 VIWSGGSTDYNAAFIS 10 NRGYSYAMDS crystal 1.97A 21.80% FAB 23-JUL-05 20050723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI POLYHYDROXYBUTYRATE ANTIBODY FV ? ? ? HOMO SAPIENS 11 RASQNINNYLH 7 AASNLQG 9 LQTHAYPLT 5 GNYMH 17 WINPKSGDTNYAQKFQG 7 GWWGMDV crystal 1.70A 19.10% FV 29-NOV-05 20051129 IMMUNOGLOBULIN MOLECULAR BASIS OF CROSS - REACTIVITY AND THE LIMITS OF ANTIBODY - ANTIGEN COMPLEMENTARITY ? KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.90A 20.50% FAB 08-FEB-94 19940208 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF SARS - COV SPIKE RECEPTOR - BINDING DOMAIN COMPLEXED WITH NEUTRALIZING ANTIBODY MOLECULE: SPIKE GLYCOPROTEIN; FRAGMENT: RECEPTOR - BINDING DOMAIN, RESIDUES 317 - 518; SYNONYM: SARS SPIKE, PEPLOMER PROTEIN, E2; ENGINEERED: YES ? IGG HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 10 QVWDSSSDYV 5 SYTIS 17 GITPILGIANYAQKFQG 9 DTVMGGMDV crystal 2.30A 19.90% FAB 24-JAN-06 20060124 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A R310 ANTIBODY COMPLEXED WITH (R) - HNE - HISTIDINE ADDUCT (R) - HNE - HISTIDINE ADDUCT ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 4 YGGY crystal 2.35A 22.50% FAB 02-FEB-06 20060202 IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FV FRAGMENT FROM AN ANTI - DANSYL SWITCH VARIANT ANTIBODY IGG2A (S) CRYSTALLIZED AT PH 6.75 ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPFT 5 DAWMD 19 EIRNKANNHATYYAESVKG 10 IYYHYPWFAY crystal 1.55A 18.40% FV 17-DEC-98 19981217 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HY33F) COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDFWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 19.00% FV 25-MAY-06 20060525 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HY50F) COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 FVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 18.60% FV 25-MAY-06 20060525 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HY53A) COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSASGSTYYNPSLKS 5 WDGDY crystal 1.90A 19.40% FV 25-MAY-06 20060525 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (Y33AY53A) COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDAWS 16 YVSASGSTYYNPSLKS 5 WDGDY crystal 2.50A 22.40% FV 25-MAY-06 20060525 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HY53F) COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSFSGSTYYNPSLKS 5 WDGDY crystal 2.30A 20.30% FV 25-MAY-06 20060525 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (HY58A) COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTAYNPSLKS 5 WDGDY crystal 2.30A 20.70% FV 26-MAY-06 20060526 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT (LY50A) COMPLEXED WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 AASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.00A 21.80% FV 26-MAY-06 20060526 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV (WILD - TYPE) COMPLEXED WITH HEN EGG LYSOZYME AT 1.8A RESOLUTION MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 19.40% FV 26-MAY-06 20060526 IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION - STATE ANALOG OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION - STATE ANALOG ? ? MUS MUSCULUS 16 RSSQTIVHSNGDTYLD 7 KVSNRFS 9 FQGSHVPPT 5 NYAMS 16 SISSGGSIYYLDSVKG 14 VSHYDGSRDWYFDV crystal 1.80A 18.70% FAB 30-MAY-06 20060530 IMMUNE SYSTEM CRYSTAL FORM II: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION - STATE ANALOG OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION - STATE ANALOG ? ? MUS MUSCULUS 16 RSSQTIVHSNGDTYLD 7 KVSNRFS 9 FQGSHVPPT 5 NYAMS 16 SISSGGSIYYLDSVKG 14 VSHYDGSRDWYFDV crystal 1.70A 20.70% FAB 30-MAY-06 20060530 IMMUNE SYSTEM THERMODYNAMIC AND STRUCTURAL ANALYSES OF HYDROLYTIC MECHANISM BY CATALYTIC ANTIBODIES ? ? ? MUS MUSCULUS 16 RSSQTIVHSNGDTYLD 7 KVSNRFS 9 FQGSHVPPT 5 NYAMS 16 SISSGGSIYYLDSVKG 11 VSHYDDWYFDV crystal 2.25A 22.30% FAB 13-JUL-06 20060713 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE DEFUCOSYLATED FC FRAGMENT FROM HUMAN IMMUNOGLOBULIN G1 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: MS704; EXPRESSION_SYSTEM_CELL: CHO; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX2160 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 19.50% FC 14-JUL-06 20060714 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF KCSA - FAB - TBA COMPLEX IN TL+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 22 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.60A 21.90% FAB 10-AUG-06 20060810 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF KCSA - FAB - TBA COMPLEX IN RB+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 22 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.50A 23.00% FAB 10-AUG-06 20060810 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FV FRAGMENT OF ANTI - CIGUATOXIN ANTIBODY COMPLEXED WITH ABC - RING OF CIGUATOXIN ABC - RING OF CIGUATOXIN ? ? MUS MUSCULUS 11 KANQDIKKKIA 7 YTSTLKS 9 LQYDNFTWT 5 TYWMQ 17 AIYPGNGDTRYSQKFKG 7 SDYGGDY crystal 1.70A 19.80% FV 08-NOV-06 20061108 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMANIZED KR127 FAB ? ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPQT 5 SSWMN 17 RIYPGDGDTNYAQKFQG 6 EYDEAY crystal 2.50A 20.70% FAB 05-MAR-07 20070305 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX OF HUMANIZED KR127 FAB AND PRES1 PEPTIDE EPITOPE MOLECULE: PRES1 / PRES2 / SURFACE PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPQT 5 SSWMN 17 RIYPGDGDTNYAQKFQG 6 EYDEAY crystal 2.60A 19.30% FAB 05-MAR-07 20070305 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HUMANIZED HYHEL - 10 FV MUTANT (HW47Y) - HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 ? ? HOMO SAPIENS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.90A 21.40% FV 14-MAR-07 20070314 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HUMANIZED HYHEL - 10 FV - HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 ? ? HOMO SAPIENS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.00A 22.10% FV 24-MAR-07 20070324 IMMUNE SYSTEM / TRANSPORT PROTEIN SOLUTION STRUCTURE OF THE COMPLEX BETWEEN IMMUNOGLOBULIN IGA1 AND HUMAN SERUM ALBUMIN MOLECULE: SERUM ALBUMIN; ENGINEERED: YES ? IGA HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 6 TSYGLH 17 GWISAGTGNTKYSQKFR 26 RDPYGGGKSEFDYWGQGTLVTVSSAS SolutionScattering N/A N/A ? 26-OCT-05 20051026 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF A ECCLC - FAB COMPLEX IN THE ABSENCE OF BOUND IONS MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.20A 26.80% FAB 09-NOV-05 20051109 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF THE E148Q MUTANT OF ECCLC, FAB COMPLEXED IN ABSENCE OF BOUND IONS MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.10A 32.80% FAB 09-NOV-05 20051109 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF THE S107A / E148Q / Y445A MUTANT OF ECCLC, IN COMPLEX WITH A FAB FRAGMENT MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.54A 25.80% FAB 10-NOV-05 20051110 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI - ARSONATE ANTIBODY ? KAPPA IGG2 MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGSTLPRT 5 SYGVN 17 YINPGKGYLSYNEKFKG 15 SFYGGSDLAVYYFDS crystal 2.80A 18.20% FAB 27-MAY-92 19920527 IMMUNE SYSTEM IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 12 - RESIDUE CYCLIC PEPTIDE (INCLUDING RESIDUES 315 - 324 OF HIV - 1 GP120) (MN ISOLATE) MOLECULE: PROTEIN (HIV - 1 GP120); SYNONYM: V3 LOOP; ENGINEERED: YES ? IGG1 MUS MUSCULUS 15 KASQGVDFDGASFMN 7 AASTLES 9 QQSHEDPLT 6 SGYSWH 16 YIHYSAGTNYNPSLKS 17 EEAMPYGNQAYYYAMDC crystal 2.80A 18.50% FAB 23-OCT-98 19981023 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF FAB' FROM THE HIV - 1 NEUTRALIZING ANTIBODY 2F5 ? ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLAAAAAAAGPVNAMDV crystal 2.05A 23.50% FAB 08-APR-99 19990408 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF FAB' FROM THE HIV - 1 NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH ITS GP41 EPITOPE MOLECULE: PROTEIN (GP41 EPITOPE); ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.00A 23.20% FAB 09-APR-99 19990409 IMMUNE SYSTEM AN ANTI - UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR (UPAR) ANTIBODY: CRYSTAL STRUCTURE AND BINDING EPITOPE ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 EISKLAS 8 QQWNYPFT 5 NFYIH 17 WIFHGSDNTEYNEKFKD 9 WGPHWYFDV crystal 1.77A 23.90% FAB 07-DEC-05 20051207 IMMUNOGLOBULIN DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L - KETTE, LAMBDA - TYP, SUBGRUPPE I (GERMAN) ? LAMBDA IGG1 HOMO SAPIENS 13 SGTSSNIGSSTVN 7 RDAMRPS 11 AAWDVSLNAYV 5 SYAMY 17 IIWDDGSDQHYADSVKG 17 DGGHGFCSSASCFGPDY crystal 1.90A 18.90% FAB 18-APR-89 19890418 IMMUNOGLOBULIN REFINED CRYSTAL STRUCTURE OF THE GALACTAN - BINDING IMMUNOGLOBULIN FAB J539 AT 1.95 - ANGSTROMS RESOLUTION ? KAPPA IGA MUS MUSCULUS 10 SASSSVSSLH 7 EISKLAS 9 QQWTYPLIT 5 KYWMS 17 EIHPDSGTINYTPSLKD 9 LHYYGYNAY crystal 1.95A 19.40% FAB 18-AUG-89 19890818 IMMUNE SYSTEM, HYDROLASE STRUCTURE OF HUMAN UROKINASE PLASMINOGEN ACTIVATOR IN COMPLEX WITH UROKINASE RECEPTOR AND AN ANTI - UPAR ANTIBODY AT 1.9 A MOLECULE: UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR; FRAGMENT: RESIDUES 23 - 297; SYNONYM: UPAR, U - PAR, MONOCYTE ACTIVATION ANTIGEN MO3, CD87 ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVSYMH 7 EISKLAS 8 QQWNYPFT 5 NFYIH 17 WIFHGSDNTEYNEKFKD 9 WGPHWYFDV crystal 1.90A 23.90% FAB 13-DEC-05 20051213 PROTON TRANSPORT,MEMBRANE PROTEIN STRUCTURE OF THE E203Q MUTANT OF THE CL - / H+ EXCHANGER CLC - EC1 FROM E.COLI MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.97A 27.20% FAB 15-DEC-05 20051215 PROTON TRANSPORT,MEMBRANE PROTEIN STRUCTURE OF THE E203Q MUTANT OF THE CL - / H+ EXCHANGER CLC - EC1 FROM E.COLI MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.32A 25.00% FAB 15-DEC-05 20051215 PROTON TRANSPORT,MEMBRANE PROTEIN STRUCTURE OF THE CL - / H+ EXCHANGER CLC - EC1 FROM E.COLI IN NABR MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? HOMO SAPIENS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.20A 25.40% FAB 15-DEC-05 20051215 FAB FRAGMENT OF A HUMANIZED VERSION OF THE ANTI-CD18 ANTIBODY 'H52' (HUH52-OZ FAB) ? ? ? SYNTHETIC GENE EXPRESSED IN (ESCHERICHIA COLI) 11 RASQDINNYLN 7 YTSTLHS 9 QQGNTLPPT 5 EYTMH 17 GINPKNGGTSHNQRFMD 15 WRGLNYGFDVRYFDV crystal 3.00A 17.60% FAB 16-JAN-94 19940116 IMMUNE SYSTEM STRUCTURE OF THE G6 FAB, A PHAGE DERIVED VEGF BINDING FAB ? ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSYTTPPT 5 DYWIH 17 GITPAGGYTYYADSVKG 11 FVFFLPYAMDY crystal 2.65A 20.00% FAB 02-JAN-06 20060102 HORMONE / GROWTH FACTOR / IMMUNE SYSTEM STRUCTURE OF THE G6 FAB, A PHAGE DERIVED FAB FRAGMENT, IN COMPLEX WITH VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; FRAGMENT: RECEPTOR BINDING DOMAIN (RESIDUES 34 - 135); SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSYTTPPT 5 DYWIH 17 GITPAGGYTYYADSVKG 11 FVFFLPYAMDY crystal 2.80A 20.10% FAB 02-JAN-06 20060102 HORMONE / GROWTH FACTOR / IMMUNE SYSTEM STRUCTURE OF THE B20 - 4 FAB, A PHAGE DERIVED FAB FRAGMENT, IN COMPLEX WITH VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; FRAGMENT: RECEPTOR BINDING DOMAIN OF VEGF (RESIDUES 34 - 135); SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQVIRRSLA 7 AASNLAS 9 QQSNTSPLT 5 ASWIH 17 AIYPYSGYTNYADSVKG 12 WGHSTSPWAMDY crystal 3.10A 20.00% FAB 02-JAN-06 20060102 IMMUNE SYSTEM COFACTOR - CONTAINING ANTIBODIES: CRYSTAL STRUCTURE OF THE ORIGINAL YELLOW ANTIBODY ? LAMBDA IGG1 HOMO SAPIENS 11 SGDVLPKKYAY 7 EDSGRPS 10 YSDISNGYPL 5 NYYMT 17 NIRPDETEKFYSDSVKG 11 VSDFGDYGPDF crystal 3.00A 24.00% ? 05-JAN-06 20060105 IMMUNE SYSTEM / DNA STRUCTURE OF FAB DNA - 1 COMPLEXED WITH A STEM - LOOP DNA LIGAND MOLECULE: 5' - D ( *CP *TP *GP *CP *CP *TP *TP *CP *AP *G) - 3'; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GGYRPYYAMDY crystal 1.95A 21.00% FAB 18-JAN-06 20060118 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING HUMAN FAB 4E10 IN COMPLEX WITH A 16 - RESIDUE PEPTIDE ENCOMPASSING THE 4E10 EPITOPE ON GP41 MOLECULE: FRAGMENT OF HIV GLYCOPROTEIN (GP41); FRAGMENT: PEPTIDE EPITOPE OF 4E10; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 1.76A 20.20% FAB 03-FEB-06 20060203 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING HUMAN FAB 4E10 IN COMPLEX WITH AN AIB - INDUCED PEPTIDE ENCOMPASSING THE 4E10 EPITOPE ON GP41 MOLECULE: FRAGMENT OF HIV GLYCOPROTEIN (GP41); FRAGMENT: PEPTIDE EPITOPE OF 4E10; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.20A 23.50% FAB 03-FEB-06 20060203 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING HUMAN FAB 4E10 IN COMPLEX WITH A THIOETHER - LINKED PEPTIDE ENCOMPASSING THE 4E10 EPITOPE ON GP41 MOLECULE: FRAGMENT OF HIV GLYCOPROTEIN GP41; FRAGMENT: PEPTIDE EPITOPE OF 4E10; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.10A 23.60% FAB 03-FEB-06 20060203 IMMUNE SYSTEM GREEN - FLUORESCENT ANTIBODY 11G10 IN COMPLEX WITH ITS HAPTEN (NITRO - STILBENE DERIVATIVE) WITH ITS HAPTEN (NITRO - STILBENE DERIVATIVE) ? ? MUS MUSCULUS 16 RSSQSLLYINGKTHLN 7 LVSKLDS 9 LQSTHFPLT 5 AYYMN 17 VINPYNGFTTYNQKFKG 9 YDYAADRVY crystal 2.75A 20.50% ? 16-FEB-06 20060216 APOPTOSIS CRYSTAL STRUCTURE OF THE ANTI - BAX MONOCLONAL ANTIBODY 6A7 AND A BAX PEPTIDE. MOLECULE: BAX PEPTIDE; FRAGMENT: BAX PEPTIDE FRAGMENT; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFNSKTRRNYLA 7 WASTRES 8 KQSYNLRT 5 DNYMS 19 FIRNKVNGYTTEYGPSVKG 12 DNGSDYRWYFDV crystal 2.30A 23.40% FAB 22-FEB-06 20060222 IMMUNE SYSTEM STRUCTURE OF ANTI - FLAG M2 FAB DOMAIN ? ? ? MUS MUSCULUS 16 RSSQAIVHANGNTYLE 7 KVANRFS 9 FQGAHAPYT 5 AYAIH 17 YIAPAAGAAAYNAAFKG 8 AAAAGADY crystal 1.85A 23.50% FAB 23-FEB-06 20060223 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - SARS M396 ANTIBODY ? ? IGG HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 10 QVWDSSSDYV 5 SYTIS 17 GITPILGIANYAQKFQG 9 DTVMGGMDV crystal 2.28A 22.10% FAB 27-FEB-06 20060227 IMMUNE SYSTEM HUMANIZED ANTIBODY C25 FAB FRAGMENT ? ? ? MUS MUSCULUS 15 RASESVDSYGHSFMQ 7 RASNLEP 9 QQSNEAPFT 5 DYYMY 17 TISDGGSYTYYPDSVKG 9 YRYDDAMDY crystal 2.50A 22.50% FAB 14-MAR-06 20060314 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE - LIKE ACTIVITY ? ? IGG2 MUS MUSCULUS 11 RASQEISGYLS 7 AASTLDS 9 LQYASSPYT 5 SFGMH 17 YISSGSSTIYYADTVKG 10 GDYYGSRGAY crystal 3.00A 21.30% FAB 07-JUL-94 19940707 VIRUS / VIRAL PROTEIN / ANTIBIOTIC CRYSTAL STRUCTURE OF SARS SPIKE PROTEIN RECEPTOR BINDING DOMAIN IN COMPLEX WITH A NEUTRALIZING ANTIBODY, 80R MOLECULE: SPIKE GLYCOPROTEIN; FRAGMENT: RBD OF SPIKE PROTEIN S1 (318 - 510); SYNONYM: PEPLOMER PROTEIN, E2, RBD; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.30A 25.10% scFv 27-MAR-06 20060327 IMMUNE SYSTEM / VIRUS / VIRAL PROTEIN CRYSTAL STRUCTURE OF A GE - GI / FC COMPLEX ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGG1 HEAVY CHAIN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: HUMAN HERPESVIRUS 1; ORGANISM_TAXID: 10306; STRAIN: KOS; GENE: GE, US8; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; EXPRESSION_SYSTEM_TAXID: 7108 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 5.00A 0.00% FC 30-MAR-06 20060330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A SINGLE CHAIN ANTIBODY SCA21 AGAINST HER2 / ERBB2 ? KAPPA ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.10A 19.10% scFv 31-MAR-06 20060331 IMMUNE SYSTEM STRUCTURE OF CATALYTIC ELIMINATION ANTIBODY 13G5 FROM A CRYSTAL IN SPACE GROUP P2 (1) ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHLPPT 5 NYGVD 16 VIWSGGSTNYNSALMS 13 HWGGYYIPYGMDH crystal 2.65A 21.50% FAB 31-MAR-06 20060331 IMMUNE SYSTEM STRUCTURE OF CATALYTIC ELIMINATION ANTIBODY 13G5 FROM A TWINNED CRYSTAL IN SPACE GROUP C2 ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHLPPT 5 NYGVD 16 VIWSGGSTNYNSALMS 8 HWGYGMDH crystal 2.45A 23.60% FAB 31-MAR-06 20060331 IMMUNE SYSTEM HEAVY AND LIGHT CHAIN VARIABLE SINGLE DOMAINS OF AN ANTI- DNA BINDING ANTIBODY HYDROLYZE BOTH DOUBLE- AND SINGLE- STRANDED DNAS WITHOUT SEQUENCE SPECIFICITY MOLECULE: NUCLEASE; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFNSRTRKNYLA 7 WASTRES 9 KQSYYHMYT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GAYKRGYAMDY crystal 2.88A 21.20% scFv 02-APR-06 20060402 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FV FRAGMENT OF A MONOCLONAL ANTIBODY SPECIFIC FOR POLY - GLUTAMINE ? ? ? MUS MUSCULUS 12 TLSSQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 DYYMY 17 FISNGGGSTYYPDTVKG 9 GRGYVWFAY crystal 2.10A 22.90% FV 26-APR-06 20060426 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MURINE FAB IN COMPLEX WITH AN 11 RESIDUE PEPTIDE DERIVED FROM STAPHYLOCOCCAL NUCLEASE MOLECULE: THERMONUCLEASE; FRAGMENT: RESIDUES: 123-133; SYNONYM: TNASE, MICROCOCCAL NUCLEASE, STAPHYLOCOCCAL NUCLEASE; EC: 3.1.31.1; ENGINEERED: YES KAPPA ? MUS MUSCULUS 15 GASKSVRTSGYSYMD 7 LVSNLES 10 SHIRELPRSS 5 DYYMY 17 WIDPENGDTEYVPTFQG 13 GVITMmgyqAMDY crystal 2.81A 22.50% FAB 26-APR-06 20060426 COMPLEX (ANTIBODY / PEPTIDE) THE THREE - DIMENSIONAL STRUCTURES OF A POLYSACCHARIDE BINDING ANTIBODY TO CRYPTOCOCCUS NEOFORMANS AND ITS COMPLEX WITH A PEPTIDE FROM A PHAGE DISPLAY LIBRARY: IMPLICATIONS FOR THE IDENTIFICATION OF PEPTIDE MIMOTOPES MOLECULE: PA1; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPWT 5 SYFLS 17 TINSNGDKTYHPDTMKG 11 RDSSASLYFDY crystal 2.40A 18.60% FAB 12-NOV-97 19971112 ION TRANSPORT CRYSTAL STRUCTURE OF CLC - EC1 IN COMPLEX WITH FAB FRAGMENT IN SECN - MOLECULE: CLC CL TRANSPORTER; SYNONYM: CLC - EC1; H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.10A 27.80% FAB 19-MAY-06 20060519 ION TRANSPORT CRYSTAL STRUCTURE OF E148A MUTANT OF CLC - EC1 IN SECN - MOLECULE: CLC CL TRANSPORTER; SYNONYM: CLC - EC1; H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.10A 28.10% FAB 19-MAY-06 20060519 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE PRE - B CELL RECEPTOR MOLECULE: IMMUNOGLOBULIN OMEGA CHAIN; FRAGMENT: LIGHT CHAIN; SYNONYM: IMMUNOGLOBULIN - RELATED PROTEIN 14.1, IMMUNOGLOBULIN LAMBDA - LIKE POLYPEPTIDE 1, IG LAMBDA - 5, CD179B ANTIGEN; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS 14 TLRNDHDIGVYSVY 7 YFSQSDK 11 PEDEAMYYCAM 5 SYWIG 17 IIYPGDSDTRYSPSFQG 10 HYYYYYGMDV crystal 2.70A 26.90% ? 22-MAY-06 20060522 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A SURROGATE LIGHT CHAIN (LAMBDA5 AND VPREB) HOMODIMER ? IOTA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: VPREB1, VPREB; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_ORGAN: EGGS; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGLL1, IGL1; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_ORGAN: EGGS; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS 0 0 0 0 0 0 crystal 2.30A 22.80% iota light 22-MAY-06 20060522 MEMBRANE PROTEIN STRUCTURE OF A K CHANNEL WITH AN AMIDE TO ESTER SUBSTITUTION IN THE SELECTIVITY FILTER MOLECULE: KCSA CHANNEL; FRAGMENT: RESIDUES 1 - 79; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.25A 23.30% FAB 07-JUN-06 20060607 IMMUNE SYSTEM / APOPTOSIS CRYSTAL STRUCTURE OF PHAGE DERIVED FAB BDF1 WITH HUMAN DEATH RECEPTOR 5 (DR5) MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B PRECURSOR; FRAGMENT: EXTRA CELLULAR DOMAIN; SYNONYM: DEATH RECEPTOR 5, TNF - RELATED APOPTOSIS - INDUCING LIGAND RECEPTOR 2, TRAIL RECEPTOR 2, TRAIL - R2, CD262 ANTIGEN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSYTTPPT 5 KSGIH 17 VIYPHDGNTAYADSVKG 11 RLALVRMWMDY crystal 2.32A 23.40% FAB 09-JUN-06 20060609 MEMBRANE PROTEIN RB+ COMPLEX OF A K CHANNEL WITH AN AMIDE TO ESTER SUBSTITUTION IN THE SELECTIVITY FILTER MOLECULE: KCSA CHANNEL; FRAGMENT: RESIDUES 1 - 79; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.25A 23.20% FAB 23-JUN-06 20060623 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CB2 FAB ? ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSRITPPT 5 SNSIH 17 WITPSDGNTDYADSVKG 10 RVCYAGGMDY crystal 1.95A 19.20% FAB 23-JUN-06 20060623 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HBR3 BOUND TO CB3S - FAB MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13C; FRAGMENT: CYSTEINE RICH DOMAIN (RESIDUES 7 - 54); SYNONYM: B CELL - ACTIVATING FACTOR RECEPTOR, BAFF RECEPTOR, BAFF - R, BLYS RECEPTOR 3, CD268 ANTIGEN; ENGINEERED: YES; MUTATION: YES KAPPA ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSQISPPT 5 SSSIH 17 WVLPSVGFTDYADSVKG 16 RVCYNRLGVCAGGMDY crystal 2.61A 20.10% FAB 23-JUN-06 20060623 MEMBRANE PROTEIN CS+ COMPLEX OF A K CHANNEL WITH AN AMIDE TO ESTER SUBSTITUTION IN THE SELECTIVITY FILTER MOLECULE: KCSA CHANNEL; FRAGMENT: RESIDUES 1 - 79; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.75A 23.90% FAB 26-JUN-06 20060626 IMMUNE SYSTEM STRUCTURE OF AN ANTI - PRP FAB, P - CLONE, IN COMPLEX WITH ITS COGNATE BOVINE PEPTIDE EPITOPE. MOLECULE: PRION PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQDIGNNLN 7 ATSSLDS 9 LQHDTFPLT 5 DSYIH 17 RIDPEDGETKYAPKFQG 9 GAYYIKEDF crystal 2.85A 22.20% FAB 27-JUN-06 20060627 METAL TRANSPORT POTASSIUM CHANNEL KCSA - FAB COMPLEX WITH TETRABUTYLAMMONIUM (TBA) MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.90A 22.50% FAB 30-JUN-06 20060630 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX FAB M75 - PEPTIDE MOLECULE: CARBONIC ANHYDRASE 9; SYNONYM: CARBONIC ANHYDRASE IX, CARBONATE DEHYDRATASE IX, CA - IX, CAIX, MEMBRANE ANTIGEN MN, P54 / 58N, RENAL CELL CARCINOMA - ASSOCIATED ANTIGEN G250, RCC - ASSOCIATED ANTIGEN G250, PMW1; EC: 4.2.1.1; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPFT 5 NYAMN 19 RIRSKSNNYATYYADSVKD 8 YGNHPFAY crystal 2.01A 17.90% FAB 04-JUL-06 20060704 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB M75 ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPFT 5 NYAMN 19 RIRSKSNNYATYYADSVKD 8 YGNHPFAY crystal 2.10A 22.40% FAB 04-JUL-06 20060704 PROTON TRANSPORT,MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIS COLI CLC CHLORIDE CHANNEL Y445E MUTANT AND FAB COMPLEX MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: 1ECCLC H+ / CL - ANTIPORTER; CLC - EC1; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: EACH SUBUNIT OF THE MUTANT HAS A SINGLE BR - ION BOUND IN THE SELECTIVITY FILTER; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.30A 28.20% FAB 07-JUL-06 20060707 IMMUNE SYSTEM / DNA HIV - 1 REVERSE TRANSCRIPTASE / FRAGMENT OF FAB 28 / DNA COMPLEX MOLECULE: HISUBUNIT OF V - 1 REVERSE TRANSCRIPTASE; SYNONYM: HIV - 1 RT; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 2.80A 27.10% FAB 10-APR-98 19980410 COMPLEX (IMMUNOGLOBULIN / PEPTIDE) ANTIGEN - ANTIBODY COMPLEX MOLECULE: HIV - 1 PROTEASE PEPTIDE; FRAGMENT: RESIDUES 36 - 46; ENGINEERED: YES ? IGG1 MUS MUSCULUS 15 RASESVDYYGKSFMN 7 AASNQGS 9 QQSKEVPWT 5 RFGMH 17 YISSGSSTIYYADTVKG 16 SGGIERYDGTYYVMDY crystal 2.20A 19.80% FAB 27-DEC-96 19961227 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL Y445H MUTANT AND FAB COMPLEX MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: 1ECCLC H+ / CL - ANTIPORTER; CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.32A 27.20% FAB 25-JUL-06 20060725 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL Y445L MUTANT AND FAB COMPLEX MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: 1ECCLC H+ / CL - ANTIPORTER; CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.30A 25.40% FAB 25-JUL-06 20060725 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL Y445W MUTANT AND FAB COMPLEX MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: 1ECCLC H+ / CL - ANTIPORTER; CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.20A 24.00% FAB 25-JUL-06 20060725 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL Y445A MUTANT AND FAB COMPLEX MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: 1ECCLC H+ / CL - ANTIPORTER; CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.41A 26.60% FAB 26-JUL-06 20060726 MEMBRANE PROTEIN STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL Y445F MUTANT AND FAB COMPLEX MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: 1ECCLC H+ / CL - ANTIPORTER; CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.40A 26.20% FAB 26-JUL-06 20060726 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF KCSA - FAB - TBA COMPLEX IN LOW K+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.75A 22.20% FAB 28-JUL-06 20060728 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF THE KCSA - FAB - TBA COMPLEX IN HIGH K+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 1.90A 22.80% FAB 28-JUL-06 20060728 IMMUNE SYSTEM FAB FRAGMENT OF HUMANIZED ANTI - VIRAL ANTIBODY MEDI - 493 (SYNAGIS TM) ? ? ? HOMO SAPIENS, MUS MUSCULUS 10 KCQLSVGYMH 7 DTSKLAS 9 FQGSGYPFT 7 TSGMSVG 16 DIWWDDKKDYNPSLKS 10 SMITNWYFDV crystal 1.80A 25.10% FAB 02-AUG-06 20060802 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE NURSE SHARK NEW ANTIGEN RECEPTOR PBLA8 VARIABLE DOMAIN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: XL1-BLUE; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PIMS100 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.35A 17.40% NAR 15-AUG-06 20060815 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE NURSE SHARK NEW ANTIGEN RECEPTOR PBLA8 VARIABLE DOMAIN IN COMPLEX WITH LYSOZYME ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: XL1-BLUE; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PIMS100; MOL_ID: 2; ORGANISM_SCIENTIFIC: GALLUS GALLUS; ORGANISM_COMMON: CHICKEN; ORGANISM_TAXID: 9031 0 0 0 0 0 0 crystal 1.80A 18.70% NAR 15-AUG-06 20060815 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE NURSE SHARK NEW ANTIGEN RECEPTOR ANCESTRAL VARIABLE DOMAIN IN COMPLEX WITH LYSOZYME ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: XL1-BLUE; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PIMS100; MOL_ID: 2; ORGANISM_SCIENTIFIC: GALLUS GALLUS; ORGANISM_COMMON: CHICKEN; ORGANISM_TAXID: 9031 0 0 0 0 0 0 crystal 2.50A 20.40% NAR 15-AUG-06 20060815 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE NURSE SHARK NEW ANTIGEN RECEPTOR ANCESTRAL VARIABLE DOMAIN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: XL1-BLUE; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PIMS100 0 0 0 0 0 0 crystal 1.92A 22.00% NAR 15-AUG-06 20060815 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF CD4M47, A SCORPION - TOXIN MIMIC OF CD4, IN COMPLEX WITH HIV - 1 YU2 GP120 ENVELOPE GLYCOPROTEIN AND ANTI - HIV - 1 ANTIBODY 17B MOLECULE: CD4M47, SCORPION - TOXIN MIMIC OF CD4; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.20A 21.40% FAB 26-AUG-06 20060826 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF [PHE23] M47, A SCORPION - TOXIN MIMIC OF CD4, IN COMPLEX WITH HIV - 1 YU2 GP120 ENVELOPE GLYCOPROTEIN AND ANTI - HIV - 1 ANTIBODY 17B MOLECULE: [PHE23] M47, SCORPION - TOXIN MIMIC OF CD4; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.40A 21.50% FAB 26-AUG-06 20060826 IMMUNE SYSTEM / VIRAL PROTEIN STRUCTURE OF FAB 7D11 FROM A NEUTRALIZING ANTIBODY AGAINST THE POXVIRUS L1 PROTEIN MOLECULE: VIRION MEMBRANE PROTEIN M25; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQTLLNSRTRKNYLA 7 WASTRES 8 KQSYNLWT 5 RYWMH 17 YINPSTGYTEYNQKFKD 10 TTVDGYDFAY crystal 3.10A 24.00% FAB 05-SEP-06 20060905 OXIDOREDUCTASE YEAST CYTOCHROME BC1 COMPLEX WITH STIGMATELLIN MOLECULE: UBIQUINOL - CYTOCHROME - C REDUCTASE COMPLEX CORE PROTEIN 2; SYNONYM: COMPLEX III SUBUNIT 2, CYTOCHROME B - C1 COMPLEX SUBUNIT 2, UBIQUINOL:CYTOCHROME - C OXIDOREDUCTASE SUBUNIT II; EC: 1.10.2.2; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 2.30A 22.20% ? 12-SEP-06 20060912 IMMUNOGLOBULIN / HYDROLASE (O - GLYCOSYL) STRUCTURE OF AN ANTIBODY - LYSOZYME COMPLEX: EFFECT OF A CONSERVATIVE MUTATION MOLECULE: HEN EGG WHITE LYSOZYME; ENGINEERED: YES; MUTATION: YES ? IGG1 MUS MUSCULUS 10 SASSSVNYMY 7 DTSKLAS 8 QQWGRNPT 5 DYWIE 17 EILPGSGSTNYHERFKG 7 GNYDFDG crystal 2.65A 0.00% FAB 03-FEB-94 19940203 IMMUNOGLOBULIN DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L - KETTE, LAMBDA - TYP, SUBGRUPPE I (GERMAN) ? LAMBDA IGG1 HOMO SAPIENS 13 SGTSSNIGSSTVN 7 RDAMRPS 11 AAWDVSLNAYV 5 SYAMY 17 IIWDDGSDQHYADSVKG 17 DGGHGFCSSASCFGPDY crystal 3.00A 20.70% FAB 18-APR-89 19890418 IMMUNOGLOBULIN CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS MOLECULE: PEPTIDE (RESIDUES 69 - 87 OF MYOHEMERYTHRIN); ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 16 RSNQTILLSDGDTYLE 7 KVSNRFS 9 FQGSHVPPT 5 RCAMS 17 GISSGGSYTFYPDTVKG 10 YSSDPFYFDY crystal 2.80A 22.00% FAB 21-MAR-91 19910321 MEMBRANE PROTEIN ION SELECTIVITY IN A SEMI - SYNTHETIC K+ CHANNEL LOCKED IN THE CONDUCTIVE CONFORMATION MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.40A 23.30% FAB 25-SEP-06 20060925 MEMBRANE PROTEIN ION SELECTIVITY IN A SEMI - SYNTHETIC K+ CHANNEL LOCKED IN THE CONDUCTIVE CONFORMATION MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 1.72A 23.30% FAB 25-SEP-06 20060925 IMMUNOGLOBULIN REFINED CRYSTAL STRUCTURE OF A RECOMBINANT IMMUNOGLOBULIN DOMAIN AND A COMPLEMENTARITY - DETERMINING REGION 1 - GRAFTED MUTANT ? KAPPA IGA MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 17 KSSQSLLNSGNQKNFLA 7 GASTRES 9 QNDHSYPLT 0 N/A 0 N/A 0 N/A crystal 2.00A 14.90% LC-dimer 01-MAR-93 19930301 IMMUNOGLOBULIN REFINED CRYSTAL STRUCTURE OF A RECOMBINANT IMMUNOGLOBULIN DOMAIN AND A COMPLEMENTARITY - DETERMINING REGION 1 - GRAFTED MUTANT ? KAPPA IGA MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 16 KSSQSLLYKDGKNFLA 7 GASTRES 9 QNDHSYPLT 0 N/A 0 N/A 0 N/A crystal 1.97A 14.90% LC-dimer 30-MAR-92 19920330 IMMUNE SYSTEM PFA1 FAB FRAGMENT ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDKSYNPSLKS 13 RAHTTVLGDWFAY crystal 2.00A 18.00% FAB 12-OCT-06 20061012 IMMUNE SYSTEM PFA1 FAB FRAGMENT COMPLEXED WITH ABETA 1 - 8 PEPTIDE MOLECULE: ABETA 1 - 8 PEPTIDE; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDRSYNPSLKS 13 RAHTTVLGDWFAY crystal 1.65A 18.40% FAB 12-OCT-06 20061012 IMMUNE SYSTEM PFA2 FAB FRAGMENT, TRICLINIC APO FORM ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDKNYNPSLKS 13 RAHNVVLGDWFAY crystal 2.30A 21.50% FAB 13-OCT-06 20061013 IMMUNE SYSTEM PFA2 FAB FRAGMENT, MONOCLINIC APO FORM ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDKNYNPSLKS 12 RAHNVLGDWFAY crystal 2.00A 23.20% FAB 13-OCT-06 20061013 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN SODIUM CHLORIDE MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 1 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.20A 24.60% FAB 19-OCT-06 20061019 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN BARIUM CHLORIDE MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 1 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.70A 24.10% FAB 19-OCT-06 20061019 IMMUNOGLOBULIN DOMAIN COMPLEX BETWEEN THE PRYSPRY DOMAIN OF TRIM21 AND IGG FC ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.35A 21.70% FC 30-JUN-06 20060630 IMMUNE SYSTEM STRUCTURE OF A PLASMODIUM VIVAX APICAL MEMBRANE ANTIGEN 1 - FAB F8.12.19 COMPLEX MOLECULE: APICAL MEMBRANE ANTIGEN 1; SYNONYM: PLASMODIUM VIVAX APICAL MEMBRANE ANTIGEN 1; ENGINEERED: YES; MUTATION: YES; KAPPA IGG1 MUS MUSCULUS 10 RARSSVSYMH 7 ATSNLAS 9 QQWSSHPPT 5 DYYMY 17 TISDGNSYTYYVDSVKG 14 DGPTDSSGYGGFGY crystal 2.50A 19.00% FAB 07-SEP-06 20060907 IMMUNE SYSTEM STRUCTURE OF A PLASMODIUM FALCIPARUM APICAL MEMBRANE ANTIGEN 1 - FAB F8.12.19 COMPLEX MOLECULE: APICAL MEMBRANE ANTIGEN 1; FRAGMENT: PFAMA1 ECTOPLASMIC REGION, RESIDUES 25 - 605; SYNONYM: PLASMODIUM FALCIPARUM APICAL MEMBRANE ANTIGEN 1; ENGINEERED: YES; MUTATION: YES; KAPPA IGG1 MUS MUSCULUS 10 RARSSVSYMH 7 ATSNLAS 9 QQWSSHPPT 5 DYYMY 17 TISDGNSYTYYVDSVKG 14 DGPTDSSGYGGFGY crystal 2.90A 21.50% FAB 18-SEP-06 20060918 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN AUTOIMMUNE COMPLEX BETWEEN A HUMAN IGM RHEUMATOID FACTOR AND IGG1 FC REVEALS A NOVEL FC EPITOPE AND EVIDENCE FOR AFFINITY MATURATION ? ? IGM MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHINESE HAMSTER OVARY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; CELL: B-LYMPHOCYTE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; OTHER_DETAILS: CD5POSITIVE B CELLS; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; CELL: B-LYMPHOCYTE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; OTHER_DETAILS: CD5POSITIVE B CELLS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.00A 22.34% FC 28-SEP-06 20060928 HYDROLASE HYALURONIDASE IN COMPLEX WITH A MONOCLONAL IGG FAB FRAGMENT MOLECULE: HYALURONONGLUCOSAMINIDASE; FRAGMENT: RESIDUES 33 - 382; SYNONYM: HYA, ALLERGEN API M 2, API M II, HYALURONIDASE; EC: 3.2.1.35; ENGINEERED: YES; ? IGG MUS MUSCULUS 11 RASENIYSYLT 7 NAKTLAE 8 QHHYGTRT 7 TSGMGVS 16 HIYWDDDKRYNPSLKS 7 YYGSVDY crystal 2.60A 21.20% FAB 23-OCT-06 20061023 IMMUNE SYSTEM FAB FRAGMENT IN COMPLEX WITH SMALL MOLECULE HAPTEN, CRYSTAL FORM - 1 WITH SMALL MOLECULE HAPTEN, CRYSTAL FORM - 1 ? ? HOMO SAPIENS 14 TGTSSDVGSNNYVS 7 GGSNRPS 11 RSWDSNLSYSV 5 NYAIN 17 NIEPYFGTANYAQKFQG 11 YFMSYKHLSDY crystal 2.80A 21.12% FAB 03-DEC-06 20061203 IMMUNE SYSTEM FAB FRAGMENT IN COMPLEX WITH SMALL MOLECULE HAPTEN, CRYSTAL FORM - 2 WITH SMALL MOLECULE HAPTEN, CRYSTAL FORM - 2 ? ? HOMO SAPIENS 14 TGTSSDVGSNNYVS 7 GGSNRPS 11 RSWDSNLSYSV 0 17 NIEPYFGTANYAQKFQG 11 YFMSYKHLSDY crystal 2.85A 23.10% FAB 03-DEC-06 20061203 COMPLEX (ANTIBODY / ANTIGEN) JEL42 FAB / HPR COMPLEX MOLECULE: HISTIDINE - CONTAINING PROTEIN; SYNONYM: HPR ? ? MUS MUSCULUS 16 RSSQSIVHGNGNTYLE 7 KISNRFS 9 FQGSHVPYT 5 TYAMH 17 LISTYSGYTNYNQKFKG 9 VMGEQYFDV crystal 2.50A 21.00% FAB 24-FEB-98 19980224 RECEPTOR / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ABT - 007 FAB FRAGMENT WITH THE SOLUBLE DOMAIN OF EPO RECEPTOR MOLECULE: ERYTHROPOIETIN RECEPTOR; FRAGMENT: EPO RECEPTOR SOLUBLE DOMAIN, RESIDUES 25 - 249; SYNONYM: EPO - R; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGIRNDLG 7 AASSLQS 9 LQHNTYPPT 5 SYYWS 16 YIGGEGSTNYNPSLKS 8 ERLGIGDY crystal 3.20A 26.00% FAB 02-JUL-07 20070702 IMMUNE SYSTEM / METAL TRANSPORT POTASSIUM CHANNEL KCSA IN COMPLEX WITH TETRABUTYLAMMONIUM IN HIGH K MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 1 - 124; SYNONYM: KCSA POTASSIUM CHANNEL; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.40A 20.50% FAB 15-AUG-08 20080815 CYTOKINE / IMMUNE SYSTEM SOLUTION STRUCTURE OF A SCFV - IL - 1B COMPLEX MOLECULE: INTERLEUKIN - 1 BETA; SYNONYM: IL - 1 BETA, CATABOLIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RTSGNIHNYLT 7 NAKTLAD 15 QHFWSLPFTFGQGTK 3 NYL 19 IYNAKTLADGVPSRFSGSG 26 GQGTKVEIKRTGGGGSGGGGSGGGGS NMR N/A N/A scFv 23-MAR-09 20090323 IMMUNE SYSTEM SOLUTION STRUCTURE OF THE KI O18 / O8 Y87H IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN ? KAPPA ? HOMO SAPIENS 11 QASQDISNYLN 7 DASNLET 9 QQYDNLPYT 0 N/A 0 N/A 0 N/A NMR N/A N/A LC-dimer 11-NOV-09 20091111 IMMUNE SYSTEM SOLUTION STRUCTURE OF THE AL - 09 H87Y IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN ? KAPPA ? HOMO SAPIENS 11 QASQDINNYLI 7 DASTLET 9 QQYDNLPYT 0 N/A 0 N/A 0 N/A NMR N/A N/A LC-dimer 11-NOV-09 20091111 STRUCTURAL GENOMICS, UNKNOWN FUNCTION NMR STRUCTURE OF THE PROTEIN NP_390037.1 FROM BACILLUS SUBTILIS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS; ORGANISM_TAXID: 1423; GENE: YOLA, BSU21540; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR: SPEEDET Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A NMR N/A N/A FAB 22-MAR-12 20120322 MEMBRANE PROTEIN, OXIDOREDUCTASE HIGH RESOLUTION STRUCTURE OF DSBB C41S BY JOINT CALCULATION WITH SOLID - STATE NMR AND X - RAY DATA MOLECULE: DISULFIDE BOND FORMATION PROTEIN B; SYNONYM: DISULFIDE OXIDOREDUCTASE; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLYT 5 SYDMS 17 YISSGGGSTYYPDTVKG 6 PDAMDY SolidStateNMR N/A N/A FAB 30-MAY-12 20120530 IMMUNOGLOBULIN RECOMBINANT LEN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: JM83 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 2.70A 21.40% LC-dimer 13-MAY-98 19980513 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF A LIGHT CHAIN DIMER CRYSTALLIZED IN WATER. CONFORMATIONAL FLEXIBILITY OF A MOLECULE IN TWO CRYSTAL FORMS ? LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.00A 18.70% LC-dimer 09-MAY-89 19890509 IMMUNE SYSTEM REFINED CRYSTAL STRUCTURE OF THE MC / PC603 FAB - PHOSPHOCHOLINE COMPLEX AT 3.1 ANGSTROMS RESOLUTION AT 3.1 ANGSTROMS RESOLUTION KAPPA IGA MUS MUSCULUS 17 KSSQSLLNSGNQKNFLA 7 GASTRES 9 QNDHSYPLT 5 DFYME 19 ASRNKGNKYTTEYSASVKG 11 NYYGSTWYFDV crystal 3.10A 18.50% FAB 15-OCT-84 19841015 IMMUNE SYSTEM BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS MOLECULE: CONJUGATE OF PORA P1.16 PEPTIDE WITH FLUORESCEIN; FRAGMENT: APEX OF EXTRACELLULAR LOOP 4 (VR2) OF PORA, RESIDUES 180 - 187; SYNONYM: P1.16, AC - TKDTNNNLC (FLUORESCEIN) - NH2; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 16 RSSQALVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPRT 5 SYWLH 17 GIYPGNRDTRYTQRFKD 12 IYFDYADFIMDY crystal 2.60A 20.20% FAB 09-JUN-99 19990609 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA (M96V) - FAB COMPLEX IN KCL MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 1 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.52A 23.50% FAB 20-OCT-06 20061020 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX OF ANTIBODY AND THE ALLERGEN BLA G 2 MOLECULE: ASPARTIC PROTEASE BLA G 2; FRAGMENT: NIG2; SYNONYM: ALLERGEN BLA G II; EC: 3.4.23. -; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQIVSTAVA 7 SASYRYT 9 QQHYNSPQT 5 DTYIH 17 RIDPANGNTRYGPKFLG 7 WVRQMDY crystal 2.81A 23.50% FAB 01-NOV-06 20061101 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A QUORUM - QUENCHING ANTIBODY IN COMPLEX WITH AN N - ACYL - L - HOMOSERINE LACTONE ANALOG WITH AN N - ACYL - L - HOMOSERINE LACTONE ANALOG LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTRNYAN 7 DTNNRAP 9 ALWYSNHWV 5 TYWIH 17 TIYPGSDNTYYDEKFKN 13 GSLYYNNYGWFGY crystal 3.18A 21.30% FAB 07-NOV-06 20061107 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (S334A) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.00A 18.30% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (T257S, S334A, S375W) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.04A 20.80% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (M95W, W96C, T257S, V275C, S334A, S375W, A433M) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.20A 20.40% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (I109C, T257S, S334A, S375W, Q428C) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 1.99A 21.10% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (T123C, T257S, S334A, S375W, G431C) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.00A 19.50% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (K231C, T257S, E267C, S334A, S375W) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.00A 20.50% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (K231C, T257S, E268C, S334A, S375W) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.00A 20.40% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.50A 20.10% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN (M95W, W96C, I109C, T123C, T257S, V275C,S334A, S375W, Q428C, G431C) COMPLEXED WITH CD4 AND ANTIBODY 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, N - TERMINAL TWO DOMAIN FRAGMENT; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.80A 19.60% FAB 20-NOV-06 20061120 VIRAL PROTEIN / IMMUNE SYSTEM HIV - 1 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH THE BROADLY NEUTRALIZING CD4 - BINDING - SITE ANTIBODY B12 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; FRAGMENT: CORE; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RSSHSIRSRRVA 7 GVSNRAS 9 QVYGASSYT 5 NFVIH 17 WINPYNGNKEFSAKFQD 18 VGPYSWDDSPQDNYYMDV crystal 2.30A 19.60% FAB 20-NOV-06 20061120 TOXIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE A COMPLEXED WITH MONOCLONAL ANTIBODY CR1 MOLECULE: BOTULINUM NEUROTOXIN TYPE A; EC: 3.4.24.69; ? ? HOMO SAPIENS 15 RASESVDSYGHSFMQ 7 RASNLEP 9 QQGNEVPFT 5 YDYMY 17 TISDGGSYTYYSDSVEG 9 YRYDDAMDY crystal 2.61A 20.80% FAB 21-NOV-06 20061121 TOXIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN TYPE A COMPLEXED WITH MONOCLONAL ANTIBODY AR2 MOLECULE: BOTULINUM NEUROTOXIN TYPE A; EC: 3.4.24.69; ? ? HOMO SAPIENS 15 RASESVDSYGHSFMQ 7 RASNLEP 9 QQGNEVPFT 5 DHYMY 17 TISDGGSYTYYSDSVEG 9 YRYDDAMDY crystal 3.79A 22.70% FAB 22-NOV-06 20061122 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 1E9 LEUH47TRP / ARGH100TRP, AN ENGINEERED DIELS - ALDERASE FAB WITH NM STEROID - BINDING AFFINITY ? ? ? MUS MUSCULUS, HOMO SAPIENS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 FQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVWAMDY crystal 2.05A 17.90% FAB 06-DEC-06 20061206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 1E9 LEUH47TRP / ARGH100TRP FAB PROGESTERONE COMPLEX IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 1E9 LEUH47TRP / ARGH100TRP FAB PROGESTERONE COMPLEX ? ? MUS MUSCULUS, HOMO SAPIENS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 FQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVWAMDY crystal 2.85A 18.60% FAB 06-DEC-06 20061206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 1E9 LEUH47TRP / ARGH100TRP FAB 5 - BETA - ANDROSTANE - 3,17 - DIONE COMPLEX IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 1E9 LEUH47TRP / ARGH100TRP FAB 5 - BETA - ANDROSTANE - 3,17 - DIONE COMPLEX ? ? MUS MUSCULUS, HOMO SAPIENS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 FQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVWAMDY crystal 2.40A 17.40% FAB 06-DEC-06 20061206 IMMUNE SYSTEM ANTI - DNA ANTIBODY ED10 ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHIPLT 5 DYYMN 15 WVYPGSIKYNEKFKD 9 WTYGSSFDY crystal 2.73A 20.40% FAB 15-JAN-07 20070115 IMMUNE SYSTEM / DNA FAB ED10 - DNA COMPLEX MOLECULE: 5' - D ( *TP *C) - 3'; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHIPLT 5 DYYMN 15 WVYPGSIKYNEKFKD 9 WTYGSSFDY crystal 1.89A 17.80% FAB 15-JAN-07 20070115 IMMUNE SYSTEM BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN DIMER, P3 (2) 21 CRYSTAL FORM ? ? ? HOMO SAPIENS 14 TGTSSDVGGYDLVS 7 EVTNRPS 11 SSYASGSTPRI 0 N/A 0 N/A 0 N/A crystal 2.60A 21.50% LC-dimer 19-JAN-07 20070119 IMMUNE SYSTEM BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN DIMER, P3 (1) 21 CRYSTAL FORM ? ? ? HOMO SAPIENS 14 TGTSSDVGGYDLVS 7 EVTNRPS 11 SSYASGSTPRI 0 N/A 0 N/A 0 N/A crystal 2.90A 23.50% LC-dimer 21-JAN-07 20070121 IMMUNE SYSTEM BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN DIMER, P4 (3) 2 (1) 2 CRYSTAL FORM ? ? ? HOMO SAPIENS 14 TGTSSDVGGYDLVS 7 EVTNRPS 11 SSYASGSTPRI 0 N/A 0 N/A 0 N/A crystal 2.20A 22.60% LC-dimer 22-JAN-07 20070122 IMMUNE SYSTEM CRYSTAL STRUCTURE OF QUORUM - QUENCHING ANTIBODY 1G9 ? LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTRNYAN 7 DTNNRAP 9 ALWYSNHWV 5 TYWIH 17 TIYPGSDNTYYDEKFKN 13 GSLYYNNYGWFGY crystal 2.85A 20.30% FAB 26-JAN-07 20070126 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF FAB 2G12 IN COMPLEX WITH PEPTIDE 2G12.1 MOLECULE: PEPTIDE 2G12.1 (ACPPSHVLDMRSGTCLAAEGK); ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.80A 23.60% FAB 31-JAN-07 20070131 IMMUNE SYSTEM THE STRUCTURE OF THE ANTI - C - MYC ANTIBODY 9E10 FAB FRAGMENT / EPITOPE PEPTIDE COMPLEX REVEALS A NOVEL BINDING MODE DOMINATED BY THE HEAVY CHAIN HYPERVARIABLE LOOPS MOLECULE: SYNTHETIC EPITOPE PEPTIDE OF 9E10; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASESVDNYGFSFMN 7 AISNRGS 9 QQTKEVPWT 5 HYGMS 17 TIGSRGTYTHYPDSVKG 18 RSEFYYYGNTYYYSAMDY crystal 2.70A 25.20% FAB 02-FEB-07 20070202 IMMUNE SYSTEM THE STRUCTURE OF THE ANTI - C - MYC ANTIBODY 9E10 FAB FRAGMENT ? ? ? MUS MUSCULUS 9 RASESVDMN 7 AISNRGS 8 QQTEVPWT 5 HYGMS 17 TIGSRGTYTHYPDSVKG 9 RSEYSAMDY crystal 2.20A 26.10% FAB 02-FEB-07 20070202 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RITUXIMAB FAB IN COMPLEX WITH AN EPITOPE PEPTIDE MOLECULE: B - LYMPHOCYTE ANTIGEN CD20; FRAGMENT: EPITOPE PEPTIDE; SYNONYM: MEMBRANE - SPANNING 4 - DOMAINS SUBFAMILY A MEMBER 1, B - LYMPHOCYTE SURFACE ANTIGEN B1, LEU - 16, BP35; ENGINEERED: YES ? ? HOMO SAPIENS, MUS MUSCULUS 10 RASSSVSYIH 7 ATSNLAS 9 QQWTSNPPT 5 SYNMH 17 AIYPGNGDTSYNQKFKG 12 STYYGGDWYFNV crystal 2.60A 23.90% FAB 06-FEB-07 20070206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FV POLYGLUTAMINE COMPLEX MOLECULE: PEPTIDE ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 12 TLSSQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 DYYMY 17 FISNGGGSTYYPDTVKG 9 GRGYVWFAY crystal 1.68A 20.00% FV 09-FEB-07 20070209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FV POLYGLUTAMINE COMPLEX MOLECULE: POLY - GLN PEPTIDE ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 12 TLSSQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 DYYMY 17 FISNGGGSTYYPDTVKG 9 GRGYVWFAY crystal 2.35A 22.60% FV 09-FEB-07 20070209 CELL ADHESION STRUCTURAL PLASTICITY IN IGSF DOMAIN 4 OF ICAM - 1 MEDIATES CELL SURFACE DIMERIZATION MOLECULE: INTERCELLULAR ADHESION MOLECULE 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIGTSIH 7 YASESIS 9 QQSNVWPFT 5 EFTMH 17 GINTINGGSSYKQSFKD 5 KGFAY crystal 2.70A 20.90% FAB 23-FEB-07 20070223 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 1.8A RESOLUTION: SE3 - MONO - 2 CRYSTAL FORM WITH THREE SE - MET SITES (M34, M51, M83) IN VHH SCAFFOLD MOLECULE: RIBONUCLEASE PANCREATIC; SYNONYM: RNASE 1, RNASE A; EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 4 YIYG 16 ADSGGGGTLYADSVKG 12 GGYELRDRTYGQ crystal 1.80A 17.30% HC-dimer 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 1.65A RESOLUTION: SE3 - MONO - 1 CRYSTAL FORM WITH THREE SE - MET SITES (M34, M51, M83) IN VHH SCAFFOLD MOLECULE: RIBONUCLEASE PANCREATIC; SYNONYM: RNASE 1, RNASE A; EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 6 YTYIYG 16 VAADSGGGGTLYADSV 14 AAGGYELRDRTYGQ crystal 1.65A 16.10% HC-dimer 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 1.8A RESOLUTION: SE5A - MONO - 1 CRYSTAL FORM WITH FIVE SE - MET SITES (M34, M51, F68M, M83, L86M) IN VHH SCAFFOLD ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; ORGANISM_COMMON: CATTLE; ORGANISM_TAXID: 9913; MOL_ID: 2; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.80A 19.50% VHH 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 1.1A RESOLUTION: SE5B - ORTHO - 1 CRYSTAL FORM WITH FIVE SE - MET SITES (L4M, M34, M51, F68M, M83) IN VHH SCAFFOLD. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; ORGANISM_COMMON: CATTLE; ORGANISM_TAXID: 9913; MOL_ID: 2; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.10A 17.40% VHH 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 2.5A RESOLUTION: SE5B - ORTHO - 2 CRYSTAL FORM WITH FIVE SE - MET SITES (L4M, M34, M51, F68M, M83) IN VHH SCAFFOLD. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; ORGANISM_COMMON: CATTLE; ORGANISM_TAXID: 9913; MOL_ID: 2; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.50A 22.50% VHH 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 2.5A RESOLUTION: SE5B - TRI CRYSTAL FORM WITH FIVE SE - MET SITES (L4M, M34, M51, F68M, M83) IN VHH SCAFFOLD. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; ORGANISM_COMMON: CATTLE; ORGANISM_TAXID: 9913; MOL_ID: 2; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.50A 23.30% VHH 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 2.3A RESOLUTION: SE5B - TETRA CRYSTAL FORM WITH FIVE SE - MET SITES (L4M, M34, M51, F68M, M83) IN VHH SCAFFOLD. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; ORGANISM_COMMON: CATTLE; ORGANISM_TAXID: 9913; MOL_ID: 2; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.30A 24.60% VHH 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM COMPLEX OF A CAMELID SINGLE - DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A AT 1.4A RESOLUTION: NATIVE MONO_1 CRYSTAL FORM MOLECULE: RIBONUCLEASE PANCREATIC; SYNONYM: RNASE 1, RNASE A; EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 7 YTYIYMG 17 VAAMDSGGGGTLYADSV 14 AAGGYELRDRTYGQ crystal 1.38A 15.70% HC-dimer 11-MAR-07 20070311 HYDROLASE / IMMUNE SYSTEM X - RAY STRUCTURE OF A CAMELID AFFINITY MATURED SINGLE - DOMAIN VHH ANTIBODY FRAGMENT IN COMPLEX WITH RNASE A MOLECULE: RIBONUCLEASE PANCREATIC; SYNONYM: RNASE 1, RNASE A; EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 YIYMG 19 VAAMDSGGGGTLYADSVKG 12 GGDALVATRYGR crystal 1.90A 18.60% HC-dimer 11-MAR-07 20070311 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF KCSA MUTANT MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.05A 21.90% FAB 20-MAR-07 20070320 VIRAL PROTEIN CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELLELDKWASLWN MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.44A 20.10% ? 22-MAR-07 20070322 VIRAL PROTEIN CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELLELDKWASLWN IN NEW CRYSTAL FORM MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 13 RRGPTGPVNAMDV crystal 2.70A 22.30% ? 22-MAR-07 20070322 VIRAL PROTEIN CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE LELDKWASLW [N - AC] MOLECULE: GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.70A 23.80% ? 22-MAR-07 20070322 IMMUNOGLOBULIN ANTIBODY FAB COMPLEXED WITH PHENCYCLIDINE COMPLEXED WITH 1 - (1 - PHENYLCYCLOHEXYL) PIPERIDINE (PCP, OR PHENCYCLIDINE); ? ? MUS MUSCULUS 16 RSSQTIVHSNGNTYLE 7 KVTNRFS 9 FQGTHAPYT 5 DYYIH 17 YIYPNNGGNGYNHKFKG 8 STWDDFDY crystal 2.20A 19.60% FAB 02-JUN-98 19980602 VIRAL PROTEIN CRYSTAL STRUCTURE OF FAB' FROM THE HIV - 1 NEUTRALIZING ANTIBODY 2F5 ? ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 12 RRGPGPVNAMDV crystal 2.05A 24.00% FAB 03-MAY-07 20070503 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDKWNSL MOLECULE: PEPTIDE EPITOPE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.60A 21.30% FAB 10-MAY-07 20070510 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELDKWKSL MOLECULE: PEPTIDE EPITOPE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.55A 21.80% FAB 10-MAY-07 20070510 PROTEIN FIBRIL ALTERED DIMER INTERFACE DECREASES STABILITY IN AN AMYLOIDOGENIC KAPPA1 BENCE JONES PROTEIN. ? KAPPA ? HOMO SAPIENS 11 TCQASQDINNY 7 IYDASTL 11 HCQQYDNLPYT 0 N/A 0 N/A 0 N/A crystal 2.55A 16.60% LC-dimer 24-MAY-07 20070524 PROTEIN FIBRIL STRUCTURE OF THE GERMLINE VK1 O18 / O8 LIGHT CHAIN VARIABLE DOMAIN HOMODIMER MOLECULE: VK1 O18 / O8 GERMLINE LIGHT CHAIN VARIABLE DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 TCQASQDISNY 7 IYDASNL 11 YCQQYDNLPYT 0 N/A 0 N/A 0 N/A crystal 1.30A 12.00% LC-dimer 25-MAY-07 20070525 IMMUNE SYSTEM MOUSE ANTI - HEN EGG WHITE LYSOZYME ANTIBODY F10.6.6 FAB FRAGMENT ? ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YTSQSMS 9 QQSGSWPRT 5 TYWIE 17 EILPGSDSTYYNEKVKG 7 GDGFYVY crystal 2.00A 19.60% FAB 06-JUN-07 20070606 IMMUNE SYSTEM STRUCTURE OF THE MALARIA ANTIGEN AMA1 IN COMPLEX WITH A GROWTH - INHIBITORY ANTIBODY MOLECULE: APICAL MEMBRANE ANTIGEN 1; FRAGMENT: DOMAINS I AND II (RESIDUES 104 - 438); ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQSVSNDVV 7 YASIRYT 9 QQGFSSPRT 5 DTSMH 17 RIDPANDNSEYDPKFQG 3 SHF crystal 2.40A 20.40% ? 10-JUN-07 20070610 IMMUNE SYSTEM STRUCTURE OF THE MALARIA ANTIGEN AMA1 IN COMPLEX WITH A GROWTH - INHIBITORY ANTIBODY MOLECULE: APICAL MEMBRANE ANTIGEN 1; FRAGMENT: DOMAINS I AND II; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQSVSNDVV 7 YASIRYT 9 QQGFSSPRT 5 DTSMH 17 RIDPANDNSEYDPKFQG 3 SHF crystal 2.30A 21.20% ? 10-JUN-07 20070610 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF TYROSINE - SULFATED 412D ANTIBODY COMPLEXED WITH HIV - 1 YU2 GP120 AND CD4 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: D1D2, IG - LIKE V - TYPE AND IG - LIKE C2 - TYPE 1 DOMAINS; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISNWLA 7 KASSLKS 9 QQHDSSPYT 5 NYAIN 17 GIIPIFNIAHYAQRFQG 19 PYPNDNDAPEEGMSWYFDL crystal 3.30A 20.20% FAB 14-JUN-07 20070614 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A STAPHYLOCOCCUS AUREUS PROTEIN (SSL7) IN COMPLEX WITH FC OF HUMAN IGA1 ? ? IGA MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHA1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: HEK293EBNA; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PAPEX-3P DERIVATIVE; MOL_ID: 2; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280; STRAIN: STRAIN NUMBER 4427 (GL1 ISOLATE); GENE: SSL7; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: AD494(DE3)PLYSS; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET32A-3C 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.20A 22.90% FC 26-JUN-07 20070626 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF THE 13F6 - 1 - 2 FAB FRAGMENT BOUND TO ITS EBOLA VIRUS GLYCOPROTEIN PEPTIDE EPITOPE. MOLECULE: ENVELOPE GLYCOPROTEIN PEPTIDE; FRAGMENT: ENVELOPE GLYCOPROTEIN PEPTIDE, RESIDUES 404 - 414; ENGINEERED: YES LAMBDA ? MUS MUSCULUS 12 TLSRQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 SYDMS 17 YISRGGGYTYYPDTVKG 14 HIYYGSSHYYAMDY crystal 2.00A 20.30% FAB 02-JUL-07 20070702 IMMUNE SYSTEM STRUCTURAL CHARACTERIZATION OF A MUTATED, ADCC - ENHANCED HUMAN FC FRAGMENT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHM; EXPRESSION_SYSTEM_STRAIN: HEK 293; EXPRESSION_SYSTEM_CELL_LINE: MAMMALIAN; EXPRESSION_SYSTEM_VECTOR_TYPE: MAMMALIAN EXPRESSION VECTOR 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.53A 23.50% FC 12-JUL-07 20070712 SIGNALING PROTEIN NEUROPILIN - 2 A1A2B1B2 DOMAINS IN COMPLEX WITH A SEMAPHORIN - BLOCKING FAB MOLECULE: NEUROPILIN - 2; FRAGMENT: CUB 1, CUB2, F5 / 8 TYPE C 1, AND C2 DOMAINS; SYNONYM: VASCULAR ENDOTHELIAL CELL GROWTH FACTOR 165 RECEPTOR 2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQAWAYLPT 5 GYGIH 17 YIYPDSGYTDYADSVKG 15 EDFRNRRRLWYVMDY crystal 2.75A 18.90% FAB 26-JUL-07 20070726 SIGNALING PROTEIN NEUROPILIN - 2 A1A2B1B2 DOMAINS IN COMPLEX WITH A SEMAPHORIN - BLOCKING FAB MOLECULE: NEUROPILIN - 2; FRAGMENT: CUB 1, CUB2, F5 / 8 TYPE C 1, AND C2 DOMAINS; SYNONYM: VASCULAR ENDOTHELIAL CELL GROWTH FACTOR 165 RECEPTOR 2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQAWAYLPT 5 GYGIH 17 YIYPDSGYTDYADSVKG 15 EDFRNRRRLWYVMDY crystal 3.10A 19.00% FAB 26-JUL-07 20070726 SIGNALING PROTEIN NEUROPILIN - 1 B1 DOMAIN IN COMPLEX WITH A VEGF - BLOCKING FAB MOLECULE: NEUROPILIN - 1; FRAGMENT: F5 / 8 TYPE C 1 DOMAIN; SYNONYM: VASCULAR ENDOTHELIAL CELL GROWTH FACTOR 165 RECEPTOR, CD304 ANTIGEN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQYFSSYLA 7 GASSRAS 9 QQYLGSPPT 5 SYAMS 17 QISPAGGYTNYADSVKG 14 GELPYYRMSKVMDV crystal 2.20A 16.20% FAB 26-JUL-07 20070726 IMMUNE SYSTEM STRUCTURE OF VEGF COMPLEXED TO A FAB CONTAINING TYR AND SER IN THE CDRS MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; SYNONYM: VEGF - A; VASCULAR PERMEABILITY FACTOR; VPF ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 11 QQYSYYYYPFT 5 SSSIH 17 YIYPSYSYTSYADSVKG 9 YYGTGAMDY crystal 3.50A 29.20% FAB 27-JUL-07 20070727 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF ANTI - HIV - 1 V3 - FAB F425 - B4E8 IN COMPLEX WITH A V3 - PEPTIDE MOLECULE: ENVELOPE GLYCOPROTEIN GP120; FRAGMENT: RESIDUES 301 - 326; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDISNYLN 7 TASNLET 10 QQYDNLGDLS 7 FSSYVMH 19 AISSDGETTYHANSVKGRF 14 DRYYETSGSNAFDV crystal 2.80A 22.20% FAB 30-JUL-07 20070730 IMMUNE SYSTEM SOLUTION STRUCTURE OF HUMAN DIMERIC IMMUNOGLOBULIN A MOLECULE: KAPPA LIGHT CHAIN IGA1; KAPPA IGA HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 6 TSYGLH 17 GWISAGTGNTKYSQKFR 26 RDPYGGGKSEFDYWGQGTLVTVSSAS SolutionScattering N/A N/A ? 02-AUG-07 20070802 HYDROLASE, IMMUNE SYSTEM PROTEASE DOMAIN OF HGFA WITH INHIBITOR FAB58 MOLECULE: HEPATOCYTE GROWTH FACTOR ACTIVATOR; FRAGMENT: HGFA PROTEASE DOMAIN; EC: 3.4.21. -; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSYTTPPT 5 GSAIH 17 IINPNGGYTYYADSVKG 8 SARFSFDY crystal 3.51A 25.40% FAB 20-AUG-07 20070820 HYDROLASE, IMMUNE SYSTEM SHORT FORM HGFA WITH INHIBITORY FAB75 MOLECULE: HEPATOCYTE GROWTH FACTOR ACTIVATOR; ENGINEERED: YES ? ? HOMO SAPIENS, SYNTHETIC CONSTRUCT 11 RASQDVSTAVA 7 SASFLYS 9 QQSYTTPPT 5 NSGIH 17 WIYPTGGATDYADSVKG 8 FWWRSFDY crystal 2.20A 19.50% FAB 20-AUG-07 20070820 IMMUNE SYSTEM PFA2 FAB COMPLEXED WITH ABETA1 - 8 MOLECULE: AMYLOID BETA PEPTIDE FRAGMENT; FRAGMENT: OCTAPEPTIDE; SYNONYM: AMYLOID BETA A4 PROTEIN, FRAGMENT; ENGINEERED: YES ? IGG2 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDKNYNPSLKS 13 RAHNVVLGDWFAY crystal 2.50A 21.10% FAB 21-AUG-07 20070821 IMMUNE SYSTEM PFA1 FAB COMPLEXED WITH GRIPI PEPTIDE FRAGMENT MOLECULE: GRIPI PEPTIDE FRAGMENT; FRAGMENT: HEXAPEPTIDE; SYNONYM: GLUTAMATE RECEPTOR INTERACTING PROTEIN 1; ENGINEERED: YES ? IGG2 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDRSYNPSLKS 13 RAHTTVLGDWFAY crystal 2.10A 20.40% FAB 21-AUG-07 20070821 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 2 FAB IN COMPLEX WITH KDO ANALOGUES WITH KDO ANALOGUES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.70A 22.10% FAB 23-AUG-07 20070823 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 2 FAB IN COMPLEX WITH KDO ANALOGUES WITH KDO ANALOGUES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.60A 21.80% FAB 23-AUG-07 20070823 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 2 FAB IN COMPLEX WITH KDO ANALOGUES WITH KDO ANALOGUES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.60A 23.00% FAB 23-AUG-07 20070823 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 2 FAB IN COMPLEX WITH KDO ANALOGUES WITH KDO ANALOGUES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.65A 23.00% FAB 24-AUG-07 20070824 VIRAL PROTEIN / IMMUNE SYSTEM NEUTRALIZATION OF DENGUE VIRUS BY A SEROTYPE CROSS - REACTIVE ANTIBODY ELUCIDATED BY CRYOELECTRON MICROSCOPY AND X - RAY CRYSTALLOGRAPHY MOLECULE: ENVELOPE PROTEIN E; FRAGMENT: RESIDUES 478 - 574; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVVRYGNSFMH 7 RASSLES 9 QQTNVDPWA 5 DTYMH 17 RIDPANGYSKYDPKFQG 7 DYEGFAY crystal 3.00A 25.90% FAB 24-AUG-07 20070824 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 2 FAB IN COMPLEX WITH KDO ANALOGUES WITH KDO ANALOGUES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.60A 23.20% FAB 24-AUG-07 20070824 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 2 FAB IN COMPLEX WITH KDO ANALOGUES WITH KDO ANALOGUES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 2.40A 24.70% FAB 24-AUG-07 20070824 IMMUNE SYSTEM STRUCTURE OF S25 - 2 IN COMPLEX WITH KO WITH KO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 2.00A 21.70% FAB 25-AUG-07 20070825 SIGNALING PROTEIN CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR MOLECULE: BETA - 2 ADRENERGIC RECEPTOR; SYNONYM: BETA - 2 ADRENOCEPTOR, BETA - 2 ADRENORECEPTOR; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDINSYLS 7 RANRLVD 9 LQYDEFPYT 5 DYYIN 17 EIYPGSGNIDYNERFKD 4 GFGY crystal 3.40A 21.70% ? 31-AUG-07 20070831 SIGNALING PROTEIN CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR MOLECULE: BETA - 2 ADRENERGIC RECEPTOR; SYNONYM: BETA - 2 ADRENOCEPTOR, BETA - 2 ADRENORECEPTOR; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDINSYLS 7 RANRLVD 9 LQYDEFPYT 5 DYYIN 17 EIYPGSGNIDYNERFKD 4 GFGY crystal 3.40A 22.60% ? 31-AUG-07 20070831 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A RECOMBINANT IGE FAB FRAGMENT IN COMPLEX WITH BOVINE BETA - LACTOGLOBULIN ALLERGEN MOLECULE: BETA - LACTOGLOBULIN; SYNONYM: BETA - LG, ALLERGEN BOS D 5; ENGINEERED: YES; ? IGE HOMO SAPIENS 11 RASQGISSRLA 7 AASSLQS 9 QQYHSYPWT 5 HHGMT 17 SLSGSGTKTHFADSVKG 12 AKRVGATGYFDL crystal 2.80A 24.60% FAB 03-SEP-07 20070903 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 1A1D - 2 COMPLEXED WITH E - DIII OF DENGUE VIRUS AT 3.8 ANGSTROM RESOLUTION MOLECULE: MAJOR ENVELOPE PROTEIN E; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVVRYGNSFMH 7 RASSLES 9 QQTNVDPWA 5 DTYMH 17 RIDPANGYSKYDPKFQG 7 DYEGFAY crystal 3.80A 31.30% FAB 05-SEP-07 20070905 VIRUS / IMMUNE SYSTEM FIT OF E PROTEIN AND FAB 1A1D - 2 INTO 24 ANGSTROM RESOLUTION CRYOEM MAP OF FAB COMPLEXED WITH DENGUE 2 VIRUS. MOLECULE: MAJOR ENVELOPE PROTEIN E; FRAGMENT: E PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVVRYGNSFMH 7 RASSLES 9 QQTNVDPWA 5 DTYMH 17 RIDPANGYSKYDPKFQG 7 DYEGFAY ElectronMicroscopy N/A N/A FAB 06-SEP-07 20070906 IMMUNE SYSTEM / RNA HIGH RESOLUTION STRUCTURE OF A SPECIFIC SYNTHETIC FAB BOUND TO P4 - P6 RNA RIBOZYME DOMAIN MOLECULE: P4 - P6 RNA RIBOZYME DOMAIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASQSVSSAVA 7 SASSLYS 9 QQSYSSPIT 5 SSSIH 17 YISSSYGYTYYADSVKG 12 RAAGMSTYGFDY crystal 1.95A 19.60% FAB 11-SEP-07 20070911 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF Q207C MUTANT OF CLC - EC1 IN COMPLEX WITH FAB MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.10A 26.20% FAB 12-SEP-07 20070912 IMMUNE SYSTEM SOLUTION STRUCTURE OF HUMAN IMMUNOGLOBULIN M MOLECULE: J CHAIN; ? ? HOMO SAPIENS 11 TGTSSGSITVN 7 RDAMRPS 11 ASWNSSDNSYV 5 SYAMY 17 IIWDDGSDQHYADSVKG 9 DGGSSAPDY SolutionScattering N/A N/A ? 20-SEP-07 20070920 GERMLINE ANTIBODY IMMUNOGLOBULIN 48G7 GERMLINE FAB - AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY ? ? ? HOMO SAPIENS 11 RASQEISGYLS 7 AASTLDS 9 LQYASYPRT 5 DTYMH 17 RIDPANGNTKYDPKFQG 5 YYGIY crystal 2.10A 21.00% FAB 14-MAY-97 19970514 IMMUNE SYSTEM FC - FRAGMENT OF MONOCLONAL ANTIBODY IGG2B FROM MUS MUSCULUS ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; STRAIN: BALB/C; CELL_LINE: MYELOMA NS-0 AND MICE SPLEEN CELLS HYBRIDOME 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.13A 20.10% FC 05-OCT-07 20071005 IMMUNOGLOBULIN STRUCTURE OF A NOVEL BENCE - JONES PROTEIN (RHE) FRAGMENT AT 1.6 ANGSTROMS RESOLUTION ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; TISSUE: URINE 13 TGSATDIGSNSVI 7 YNDLLPS 11 AAWNDSLDEPG 0 N/A 0 N/A 0 N/A crystal 1.60A 14.90% LC-dimer 13-JUN-83 19830613 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE TEPC15 - VK45.1 ANTI - 2 - PHENYL - 5 - OXAZOLONE NQ10 - 1.12 SCFV IN COMPLEX WITH THE HAPTEN MOLECULE: NQ10 - 1.12 ANTI - PHOX ANTIBODY; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 DYYMA 19 FIRNKANGYTTDYSASVKG 10 GDYYGAWFAY crystal 2.90A 22.80% FV 02-MAR-07 20070302 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOCLONAL ANTIBODY DIRECTED AGAINST AN ANTIGENIC DETERMINANT COMMON TO OGAWA AND INABA SEROTYPES OF VIBRIO CHOLERAE O1 ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGDTYLE 7 KVSNRFS 9 FQGSHVPRT 5 SNWIN 17 HISPGSSSTNYNEKFKS 10 EETVRASFGN crystal 2.50A 21.30% FAB 10-APR-07 20070410 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HRAS (G12V) - ANTI - RAS FV COMPLEX MOLECULE: GTPASE HRAS; FRAGMENT: RESIDUES 1 - 166; SYNONYM: H - RAS ONCOPROTEIN, TRANSFORMING PROTEIN P21, P21RAS, H - RAS - 1, C - H - RAS, HA - RAS; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSISSYLN 7 SASVLQS 9 QQSVMIPMT 5 TFSMN 17 YISRTSKTIYYADSVKG 6 GRFFDY crystal 2.00A 19.80% FV 27-APR-07 20070427 IMMUNE SYSTEM STRUCTURE OF THE COMPLEX OF ANTIBODY MN423 WITH A FRAGMENT OF TAU PROTEIN MOLECULE: PEPTIDE FRAGMENT; ? ? MUS MUSCULUS 11 RASKSIRKFLA 7 SGSTLQS 9 QQHNDYPLT 5 DYYMS 19 LIRNKAKGYTTEYSASVKG 11 DNGAARATFAY crystal 1.65A 16.00% FAB 22-MAY-07 20070522 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN IMMUNOGEN SPECIFIC ANTI - MANNOPYRANOSIDE MONOCLONAL ANTIBODY FAB FRAGMENT ? ? ? MUS MUSCULUS 11 RASQDINNYLN 7 YTSNLHS 9 QQGNTLPRT 5 NYWID 17 EILPGSGSTNYNEKFRG 10 RGYWAYDFDY crystal 2.80A 24.24% FAB 30-JUL-07 20070730 IMMUNE SYSTEM UNUSUAL TWINNING IN CRYSTALS OF THE CITS BINDING ANTIBODY FAB FRAGMENT F3P4 ? ? ? SYNTHETIC CONSTRUCT 12 RASQSVSSNYLA 7 DSSSRAT 9 HQYSDISPT 5 NSAMH 17 SIWYSGSNTYYADSVKG 10 FAGGWGAYDV crystal 1.92A 15.53% FAB 31-JUL-07 20070731 CELL ADHESION / IMMUNE SYSTEM RE - REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST L - 739758 MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 3.10A 17.90% ? 18-SEP-07 20070918 CELL ADHESION / IMMUNE SYSTEM RE - REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.80A 16.40% ? 10-OCT-07 20071010 CELL ADHESION / IMMUNE SYSTEM RE - REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.75A 14.60% ? 10-OCT-07 20071010 CELL ADHESION / IMMUNE SYSTEM RE - REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.90A 16.90% ? 10-OCT-07 20071010 CELL ADHESION / IMMUNE SYSTEM RE - REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST EPTIFIBATIDE MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.90A 16.60% ? 10-OCT-07 20071010 CELL ADHESION / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQAGDV MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.51A 15.00% ? 10-OCT-07 20071010 CELL ADHESION / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE,LGGAKQAGDV MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.80A 15.80% ? 10-OCT-07 20071010 CELL ADHESION / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQRGDV MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.59A 14.30% ? 10-OCT-07 20071010 CELL ADHESION / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, LGGAKQRGDV MOLECULE: INTEGRIN BETA - 3; FRAGMENT: HEADPIECE, RESIDUES 27 - 487; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.40A 15.00% ? 10-OCT-07 20071010 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HRAS (G12V) - ANTI - RAS FV (DISULFIDE FREE MUTANT) COMPLEX MOLECULE: GTPASE HRAS; FRAGMENT: RESIDUES 1 - 166; SYNONYM: TRANSFORMING PROTEIN P21, P21RAS, H - RAS - 1, C - H - RAS, HA - RAS, H - RAS ONCOPROTEIN, TRANSFORMING PROTEIN P21; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSISSYLN 7 SASVLQS 10 AQQSVMIPMT 5 TFSMN 17 YISRTSKTIYYADSVKG 9 VARGRFFDY crystal 2.70A 21.50% FV 19-NOV-07 20071119 COMPLEX (HEMAGGLUTININ / IMMMUNOGLOBULIN) INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY MOLECULE: HEMAGGLUTININ; FRAGMENT: PROTEOLYTIC FRAGMENT "HA TOP" CONTAINING HA1 RESIDUES 28 - 328; ENGINEERED: YES LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SNGVH 16 VIWAGGNTNYNSALMS 14 DFYDYDVFYYAMDY crystal 3.25A 19.80% FAB 22-DEC-97 19971222 COMPLEX (HEMAGGLUTININ / IMMUNOGLOBULIN) INFLUENZA VIRUS HEMAGGLUTININ, (ESCAPE) MUTANT WITH THR 131 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY MOLECULE: HEMAGGLUTININ; FRAGMENT: PROTEOLYTIC FRAGMENT "HA TOP" CONTAINING HA1 RESIDUES 28 - 328; ENGINEERED: YES; MUTATION: YES LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SNGVH 16 VIWAGGNTNYNSALMS 14 DFYDYDVFYYAMDY crystal 3.25A 18.80% FAB 22-DEC-97 19971222 COMPLEX (HEMAGGLUTININ / IMMMUNOGLOBULIN) INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY MOLECULE: HEMAGGLUTININ; FRAGMENT: PROTEOLYTIC FRAGMENT "HA TOP" CONTAINING HA1 RESIDUES 28 - 328; ENGINEERED: YES; MUTATION: YES LAMBDA ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SNGVH 16 VIWAGGNTNYNSALMS 14 DFYDYDVFYYAMDY crystal 3.25A 18.80% FAB 22-DEC-97 19971222 IMMUNE SYSTEM STRUCTURE OF ANTI - COLLAGEN TYPE II FAB CIIC1 ? ? ? MUS MUSCULUS 15 RASKSVDSYGNSFME 7 RASNLES 9 QQSNEDPYT 5 SYWMN 17 MIHPSDSETRLSQKFKD 10 LKPGGTWFAY crystal 2.10A 21.60% FAB 08-JAN-08 20080108 IMMUNE SYSTEM ANTI TRIMERIC LEWIS X FAB54 - 5C10 - A ANTIGEN BINDING FRAGMENT; ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTFLQ 7 KVSNRFS 9 SQTTHVPWT 7 SSAMSVG 16 HIWWNDDKYYNPALKS 8 IPGFGFDY crystal 2.50A 20.60% FAB 10-MAR-08 20080310 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RABBIT IGG FC FRAGMENT ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; ORGANISM_COMMON: RABBIT; ORGANISM_TAXID: 9986; OTHER_DETAILS: FC FRAGMENT, COMMERCIALLY AVAILABLE RABBIT IGG PURIFIED FROM SERUM (SIGMA-ALDRICH, UK) 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.95A 16.76% FC 27-MAY-08 20080527 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR - B IN COMPLEX WITH A NEUTRALIZING ANTIBODY FAB FRAGMENT MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR B; SYNONYM: VEGF - B, VEGF - RELATED FACTOR, VRF, VASCULAR ENDOTHELIAL GROWTH FACTOR - B; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDISNFLN 7 YTSTLHS 9 QQGKTLPPT 5 GFWIH 17 HINPGNGGTNYNEKFKR 11 SYSNYVRAMDY crystal 3.40A 28.60% FAB 23-JUN-08 20080623 ALLERGEN CRYSTAL STRUCTURE OF THE MAJOR GRASS POLLEN ALLERGEN PHL P 2 IN COMPLEX WITH ITS SPECIFIC IGE - FAB MOLECULE: POLLEN ALLERGEN PHL P 2; FRAGMENT: RESIDUES 27 - 122; SYNONYM: TIMOTHY GRASS POLLEN ALLERGEN PHL P 2, PHL P II; ENGINEERED: YES; ? IGG HOMO SAPIENS 11 RASQRINTYLN 7 AASSLQS 9 QESLSASYT 7 SGGYYWS 16 YIYHSGNTYYNPSLKS 8 LDGYTLDI crystal 1.90A 17.90% FAB 08-JUL-08 20080708 CYTOKINE STRUCTURE OF IL - 17A IN COMPLEX WITH A POTENT, FULLY HUMAN NEUTRALISING ANTIBODY MOLECULE: INTERLEUKIN - 17A; FRAGMENT: RESIDUES 20 - 155; SYNONYM: IL - 17A, IL - 17, CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8, CTLA - 8, INTERLEUKINE - 17A; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSLANYYVQ 7 ANNQRPS 11 YCQTYDPYSVV 5 SYAMS 17 AISGSGGSTYYADSVKG 9 DLIHGVTRN crystal 2.63A 21.50% FAB 09-JUL-08 20080709 CYTOKINE CRYSTAL STRUCTURE OF HUMAN IL - 18 COMPLEXED TO MURINE REFERENCE ANTIBODY 125 - 2H FAB MOLECULE: INTERLEUKIN - 18; SYNONYM: IL - 18, INTERFERON - GAMMA - INDUCING FACTOR, IFN - GAMMA - INDUCING FACTOR, INTERLEUKIN - 1 GAMMA, IL - 1 GAMMA, IBOCTADEKIN; ENGINEERED: YES; MUTATION: YES; ? IGG MUS MUSCULUS 11 RASQDIGSKLY 7 ATSSLDS 9 LQYASSPYT 5 DYFIY 17 DIDPYNGDTSYNQKFRD 4 GLRF crystal 1.49A 16.40% FAB 10-JUL-08 20080710 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MURINE REFERENCE ANTIBODY 125 - 2H FAB FRAGMENT ? ? IGG MUS MUSCULUS 11 RASQDIGSKLY 7 ATSSLDS 9 LQYASSPYT 5 DYFIY 17 DIDPYNGDTSYNQKFRD 4 GLRF crystal 2.36A 18.70% FAB 10-JUL-08 20080710 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG ABT - 325 FAB FRAGMENT ? ? IGG HOMO SAPIENS 11 RASESISSNLA 7 TASTRAT 10 QQYNNWPSIT 5 SYWIG 17 FIYPGDSETRYSPTFQG 12 VGSGWYPYTFDI crystal 1.49A 15.50% FAB 10-JUL-08 20080710 IMMUNE SYSTEM STRUCTURE OF HUMAN MDM4 N - TERMINAL DOMAIN BOUND TO A SINGLE DOMAIN ANTIBODY MOLECULE: MDM4 PROTEIN; FRAGMENT: RESIDUES 16 - 116; SYNONYM: P53 - BINDING PROTEIN MDM4, MDM2 - LIKE P53 - BINDING PROTEIN, PROTEIN MDMX, DOUBLE MINUTE 4 PROTEIN, HUMAN MDM4; ENGINEERED: YES; ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 EYAML 17 GINARGYTTYYADSVKG 15 PWYPFMASKGSEFDY crystal 2.00A 20.70% HC-dimer 28-JUL-08 20080728 IMMUNE SYSTEM / METAL TRANSPORT POTASSIUM CHANNEL KCSA - FAB COMPLEX WITH TETRAOCTYLAMMONIUM MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: RESIDUES 1 - 124; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.40A 20.40% FAB 14-AUG-08 20080814 IMMUNE SYSTEM STRUCTURE OF AN AVIAN IGY - FC 3 - 4 FRAGMENT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GALLUS GALLUS; ORGANISM_COMMON: CHICKEN; ORGANISM_TAXID: 9031; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_CELL_LINE: NS0; EXPRESSION_SYSTEM_PLASMID: PRY 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.75A 17.10% FC 08-DEC-08 20081208 IMMUNE SYSTEM ANTI CITRULLINATED COLLAGEN TYPE 2 ANTIBODY ACC4 ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPLT 5 DYSIH 17 WINTETGEPTYTDDFKG 9 ATTATELAY crystal 1.50A 17.10% FAB 16-DEC-08 20081216 IMMUNE SYSTEM ANTI CITRULLINATED COLLAGEN TYPE 2 ANTIBODY ACC4 IN COMPLEX WITH A CITRULLINATED PEPTIDE MOLECULE: COLLAGEN DERIVED PEPTIDE PCII - CIT1; OTHER_DETAILS: BASED ON THE C1 (359 - 367) EPITOPE OF COLLAGEN TYPE II WITH A CIRULLINE AT POSITION 360 ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPLT 5 DYSIH 17 WINTETGEPTYTDDFKG 9 ATTATELAY crystal 2.21A 23.70% FAB 17-DEC-08 20081217 IMMUNE SYSTEM STRUCTURE OF FAB FRAGMENT OF THE ICSM 18 - ANTI - PRP THERAPEUTIC ANTIBODY AT 1.57 A RESOLUTION. ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 HQWRSNPYT 5 DYNLD 17 NVYPNNGVTGYNQKFRG 7 YYYDVSY crystal 1.57A 18.50% FAB 23-JAN-09 20090123 IMMUNE SYSTEM STRUCTURE OF ICSM 18 (ANTI - PRP THERAPEUTIC ANTIBODY) FAB FRAGMENT COMPLEXED WITH HUMAN PRP FRAGMENT 119 - 231 MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: RESIDUES 119 - 231; SYNONYM: PRP27 - 30, PRP33 - 35C, ASCR, PRP; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 HQWRSNPYT 5 DYNLD 17 NVYPNNGVTGYNQKFRG 7 YYYDVSY crystal 2.90A 21.00% FAB 23-JAN-09 20090123 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN IGG1 FC GLYCOFORM (MAN9GLCNAC2) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: CRL-1573; EXPRESSION_SYSTEM_CELL_LINE: 293T; EXPRESSION_SYSTEM_TISSUE: EMBRYONIC KIDNEY; EXPRESSION_SYSTEM_PLASMID: PHLSEC 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.51A 21.90% FC 06-FEB-09 20090206 IMMUNE SYSTEM THE HIGH RESOLUTION CRYSTAL STRUCTURE OF IGE FC ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_CELL_LINE: MOUSE MYELOMA NS0; EXPRESSION_SYSTEM_PLASMID: PEE6 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 19.49% FC 26-AUG-09 20090826 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HGFA IN COMPLEX WITH THE ALLOSTERIC NON - INHIBITORY ANTIBODY FAB40.DELTATRP MOLECULE: HEPATOCYTE GROWTH FACTOR ACTIVATOR SHORT CHAIN; EC: 3.4.21. -; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSNRAPAT 5 GTYIH 17 GIYPAGGATYYADSVKG 8 WAWPAFDY crystal 2.90A 21.60% FAB 01-OCT-09 20091001 HYDROLASE / HYDROLASE INHIBITOR CRYSTAL STRUCTURE OF HGFA IN COMPLEX WITH THE ALLOSTERIC NON - INHIBITORY ANTIBODY FAB40.DELTATRP AND AC - KQLR - CHLOROMETHYLKETONE MOLECULE: HEPATOCYTE GROWTH FACTOR ACTIVATOR SHORT CHAIN; EC: 3.4.21. -; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSNRAPAT 5 GTYIH 17 GIYPAGGATYYADSVKG 8 WAWPAFDY crystal 2.70A 22.60% FAB 01-OCT-09 20091001 VIRAL PROTEIN STRUCTURES OF LACTOCOCCAL PHAGE P2 BASEPLATE SHED LIGHT ON A NOVEL MECHANISM OF HOST ATTACHMENT AND ACTIVATION IN SIPHOVIRIDAE MOLECULE: PUTATIVE RECEPTOR BINDING PROTEIN; FRAGMENT: RESIDUES 2 - 264; ENGINEERED: YES; OTHER_DETAILS: LACTOCOCCAL PHAGE P2 ORF18; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NWCMG 17 ALNFDYDMTYYADSVKG 14 RSGGFSSNRELYDG crystal 2.60A 17.94% HC-dimer 01-DEC-09 20091201 CONTRACTILE PROTEIN GELSOLIN NANOBODY MOLECULE: GELSOLIN NANOBODY; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 MYRMG 19 VGTMVWSSDTIYYADSVKG 13 GAGWAGTMTDYNY crystal 1.34A 21.28% HC-dimer 03-JAN-10 20100103 CONTRACTILE PROTEIN GELSOLIN NANOBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.10A 20.40% Nanobody 03-JAN-10 20100103 CONTRACTILE PROTEIN GELSOLIN NANOBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.06A 21.40% Nanobody 03-JAN-10 20100103 IMMUNE SYSTEM STRUCTURE OF A SINGLE DOMAIN CAMELID ANTIBODY FRAGMENT IN COMPLEX WITH A C - TERMINAL PEPTIDE OF ALPHA - SYNUCLEIN MOLECULE: ALPHA - SYNUCLEIN PEPTIDE; FRAGMENT: C - TERMINAL FRAGMENT OF ALPHA - SYNUCLEIN, RESIDUES 132 - 140; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 SYCMG 18 RINGLGGVKTAYADSVKD 16 KFSPGYCGGSWSNFGY crystal 1.62A 16.00% HC-dimer 18-FEB-10 20100218 IMMUNE SYSTEM IMPLICATIONS OF THE HIV - 1 REV DIMER STRUCTURE AT 3.2A RESOLUTION FOR MULTIMERIC BINDING TO THE REV RESPONSE ELEMENT MOLECULE: PROTEIN REV; SYNONYM: ART / TRS, ANTI - REPRESSION TRANSACTIVATOR, REGULATOR OF EXPRESSION OF VIRAL PROTEINS; ENGINEERED: YES ? ? UNCLASSIFIED 11 QASQSISSWLS 7 DASNLAS 12 LGGYPAASYRTA 5 GFWLN 17 AIYRGSGSEWYASWAKG 10 DTTDNGYFTI crystal 3.17A 23.46% FAB 01-MAR-10 20100301 IMMUNE SYSTEM STRUCTURE OF THE BETA2_MICROGLOBULIN INVOLVED IN AMYLOIDOGENESIS MOLECULE: BETA - 2 - MICROGLOBULIN; FRAGMENT: RESIDUES 27 - 119; SYNONYM: BETA - 2 - MICROGLOBULIN FORM PI 5.3; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 RYCMA 17 RINSGRDITYYADSVKG 19 DIPLRCRDIVAKGGDGFRY crystal 2.16A 23.96% HC-dimer 07-MAR-10 20100307 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING LLAMA VHH D7 AND ITS MODE OF HIV - 1 GP120 INTERACTION ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SHDMG 17 AISWSGGTTNYVDSVKG 18 KWRPLRYSDNPSNSDYNY crystal 1.50A 16.70% HC-dimer 29-MAR-10 20100329 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB DOMAIN OF OMALIZUMAB AT 2.41A MOLECULE: OMALIZUMAB HEAVY CHAIN; ? ? HOMO SAPIENS 15 RASQSVDYDGDSYMN 7 AASYLES 9 QQSHEDPYT 6 SGYSWN 16 SITYDGSTNYNPSVKG 12 GSHYFGHWHFAV crystal 2.42A 22.30% FAB 30-MAR-10 20100330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI - EGFR ANTIBODY 7A7 ? ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPWT 5 RYAMS 17 TISSGGSYSYYPDSVKG 7 DSGGFAY crystal 1.40A 14.54% FAB 09-JUL-10 20100709 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 15 ANTIBODY IN COMPLEX WITH HUMAN IL - 15 MOLECULE: INTERLEUKIN 15; ENGINEERED: YES; ? ? HOMO SAPIENS 8 SGSTNYVY 7 RDRRRPS 11 AWYDRELSEWV 5 SFGIS 17 WISAFNGYTKYAQKFQD 16 DPAAWPLQQSLAWFDP crystal 2.60A 24.81% ? 01-SEP-10 20100901 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3 MOLECULE: ENVELOPE GLYCOPROTEIN H; FRAGMENT: RESIDUES 107 - 639; SYNONYM: GH; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASKSVSTSGYSYMY 7 LASNLES 9 QHSRELPWT 5 SYWMN 17 RIDPSDNETHYNQDFKD 9 LGYVYGFDY crystal 2.05A 18.87% FAB 08-SEP-10 20100908 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HK20 FAB IN COMPLEX WITH A GP41 MIMETIC 5 - HELIX MOLECULE: TRANSMEMBRANE PROTEIN GP41; FRAGMENT: 5 - HELIX INNER - CORE MIMETIC COMPRISED OF REPEATS OF RESIDUES 543 - 582 AND 625 - 662; ENGINEERED: YES; OTHER_DETAILS: SEQUENCE DERIVED FROM UNIPROT AC P04578 WHERE THREE REGIONS EACH EQUIVALENT TO AA 543 - 582 ARE INTERSPERSED BY TWO DIFFERENT REGIONS (EACH EQUIVALENT TO AA 625 - 662) . LINKERS GGSGG AND GSSGG JOIN THE REGIONS AND ALTERNATE STARTING WITH GGSGG. A METHIONINE INITIATES AND A TAIL CONTAINS GGHHHHHHG. CF\: ROOT ET AL, SCIENCE\: VOL. 291. NO. 5505,PP. 884 - 888,2001; ? ? HOMO SAPIENS 11 QASQDIRNHLN 7 DASNLAT 10 QHYDDLPRIT 5 RLAMS 17 GIMPIFDITNYAQKFQG 13 ASYSSSSPYAFDI crystal 2.30A 23.91% FAB 13-SEP-10 20100913 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CAPSID PROTEIN C - TERMINAL DOMAIN (146 - 231) IN COMPLEX WITH A CAMELID VHH. MOLECULE: GAG POLYPROTEIN; FRAGMENT: C - TERMINAL DOMAIN, RESIDUES 146 - 231; SYNONYM: HIV - 1 CAPSID PROTEIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 MSNVM 17 AAIRGGDMSTVYDDSVK 5 ASGSS crystal 1.32A 16.18% HC-dimer 03-OCT-10 20101003 HYDROLASE / ANTIBODY THE CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH 1D05 FAB MOLECULE: FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05; FRAGMENT: LIGHT CHAIN CONSTANT DOMAIN, RESIDUES 108 - 213; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGIRSALN 7 NGSTLQS 8 QQFDGDPT 5 SHAIS 17 GINPILGIANYAQKFQG 22 HYEIQIGRYGMNVYYLMYRFAS crystal 2.70A 20.29% FAB 10-OCT-10 20101010 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CAPSID PROTEIN C - TERMINAL DOMAIN (146 - 220) IN COMPLEX WITH A CAMELID VHH. MOLECULE: CAPSID PROTEIN P24; FRAGMENT: C - TERMINAL DOMAIN, RESIDUES 278 - 352; SYNONYM: HIV - 1 CAPSID PROTEIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 MSNVM 17 AAIRGGDMSTVYDDSVK 5 ASGSS crystal 1.89A 17.59% HC-dimer 22-OCT-10 20101022 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODY MOLECULE: THYROTROPIN RECEPTOR; FRAGMENT: LEUCINE RICH REPEAT DOMAIN, RESIDUES 22 - 260; SYNONYM: THYROID - STIMULATING HORMONE RECEPTOR, TSH - R; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSSSDIGSNYVS 7 DNNKRPS 11 GTWDSRLGIAV 5 DNWIG 17 IIYPGDSDTRYSPSFQG 10 LDWNYNPLRY crystal 1.90A 17.94% FAB 05-NOV-10 20101105 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A CAMELID VHH RAISED AGAINST THE HIV - 1 CAPSID PROTEIN C - TERMINAL DOMAIN. ? ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 MSNVM 17 AAIRGGDMSTVYDDSVK 5 ASGSS crystal 1.67A 18.15% HC-dimer 10-NOV-10 20101110 IMMUNE SYSTEM / PEPTIDE CRYSTAL STRUCTURE OF THE HIV - 1 CAPSID PROTEIN C - TERMINAL DOMAIN IN COMPLEX WITH A CAMELID VHH AND THE CAI PEPTIDE. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS; ORGANISM_COMMON: HIV-1; ORGANISM_TAXID: 12721; STRAIN: NL4-3; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3)CODONPLUS-RIL; EXPRESSION_SYSTEM_PLASMID: PET11C; MOL_ID: 2; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_COMMON: ALPACA; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 0 0 0 0 0 crystal 1.65A 19.35% VHH 10-NOV-10 20101110 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RECOMBINANT A.17 ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 10 GTWDSSLNPV 6 SGYYWG 16 SIYHSGSTYYNPSLKS 10 LTQSSHNDAN crystal 1.50A 16.76% FAB 24-NOV-10 20101124 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PHOSPHONATE - MODIFIED RECOMBINANT A.17 ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 10 GTWDSSLNPV 6 SGYYWG 16 SIYHSGSTYYNPSLKS 10 LTQSSHNDAN crystal 1.36A 16.26% FAB 24-NOV-10 20101124 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - (4 - HYDROXY - 3 - NITROPHENYL) - ACETYL MURINE GERMLINE MONOCLONAL ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE YQLRPNAETLRF MOLECULE: PHAGE DISPLAY DERIVED ANTIGEN; FRAGMENT: PEPTIDE, RESIDUES 1 - 12 ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTAYNEKFKS 11 YDYYGGSYFDY crystal 2.40A 24.07% FAB 01-DEC-10 20101201 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - (4 - HYDROXY - 3 - NITROPHENYL) - ACETYL MURINE GERMLINE ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE GDPRPSYISHLL MOLECULE: PHAGE DISPLAY DERIVED ANTIGEN; FRAGMENT: PEPTIDE, RESIDUES 1 - 12 ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTAYNEKFKS 11 YDYYGGSYFDY crystal 2.50A 23.39% FAB 30-NOV-10 20101130 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - (4 - HYDROXY - 3 - NITROPHENYL) - ACETYL MURINE GERMLINE MONOCLONAL ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE PPYPAWHAPGNI MOLECULE: PHAGE DISPLAY DERIVED ANTIGEN; FRAGMENT: PEPTIDE, RESIDUES 1 - 12 ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTAYNEKFKS 11 YDYYGGSYFDY crystal 2.40A 23.44% FAB 30-NOV-10 20101130 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI - (4 - HYDROXY - 3 - NITROPHENYL) - ACETYL MURINE GERMLINE ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE DLWTTAIPTIPS MOLECULE: DODECAPEPTIDE (DLWTTAIPTIPS); ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTAYNEKFKS 11 YDYYGGSYFDY crystal 2.70A 23.05% FAB 18-DEC-10 20101218 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE PATHOGENIC AUTOANTIBODY CIIC1 IN COMPLEX WITH THE TRIPLE - HELICAL C1 PEPTIDE MOLECULE: C1; FRAGMENT: C1 - EPITOPE; OTHER_DETAILS: TRIPLE - HELICAL SYNTHETIC PEPTIDE, CHAINS CROSSLINKED AT C - TERMINUS, CONTAINS C1 - EPITOPE OF COLLAGEN TYPE II FROM MOUSE FLANKED BY GPO REPEATS; ? ? MUS MUSCULUS 15 RASKSVDSYGNSFME 7 RASNLES 9 QQSNEDPYT 5 SYWMN 17 MIHPSDSETRLSQKFKD 10 LKPGGTWFAY crystal 2.20A 19.13% FAB 17-JAN-11 20110117 IMMUNE SYSTEM / VIRAL PROTEIN STRUCTURE OF AN EBOLAVIRUS - PROTECTIVE ANTIBODY IN COMPLEX WITH ITS MUCIN - DOMAIN LINEAR EPITOPE MOLECULE: ENVELOPE GLYCOPROTEIN; FRAGMENT: RESIDUES 477 - 493; SYNONYM: GP, GP1 ? ? MUS MUSCULUS 15 RASKSVSTSGYSYMH 7 LVSNLES 9 QHIAELTRT 5 DYVIS 17 EFYPGTDSTYYTENFKG 4 AFDY crystal 2.80A 23.86% ? 25-JAN-11 20110125 IMMUNE SYSTEM THE HIGH - AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: PHLSEC; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_CELL_LINE: MOUSE MYELOMA NS0; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: PEE6 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.40A 24.80% FC 01-FEB-11 20110201 IMMUNE SYSTEM / TOXIN CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOFFMANN MOLECULE: BETA - MAMMAL TOXIN CN2; SYNONYM: CN2 TOXIN, TOXIN 2, TOXIN II.9.2.2 ? ? HOMO SAPIENS 14 ATLSCRASQSVRSY 7 RLLFSDA 14 AIYYCQQYRYSPRT 5 NYAMH 17 GISRSSGDIDYADSVKG 8 GGVGSFDT crystal 2.55A 19.45% FV 09-MAR-11 20110309 IMMUNE SYSTEM / TOXIN CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOFFMANN MOLECULE: BETA - MAMMAL TOXIN CN2; SYNONYM: CN2 TOXIN, TOXIN 2, TOXIN II.9.2.2 ? ? HOMO SAPIENS 11 CRASQSVRSYL 7 SDASNRA 10 CQQYRYSPRT 5 NYAMH 17 GISRSSGDIDYADSVKG 8 GGVGSFDT crystal 1.90A 18.74% FV 10-MAR-11 20110310 IMMUNE SYSTEM STRUCTURE OF HUMAN ANTI - NICOTINE FAB FRAGMENT IN COMPLEX WITH NICOTINE WITH NICOTINE ? ? HOMO SAPIENS 13 SGSSSNIGSNYVY 7 RNNQRPS 11 AAWDDSLSAWV 1 G 16 SIYSSGSTYYNPSLKS 13 WFGDLLSLKGVEL crystal 1.85A 22.65% FAB 25-MAY-11 20110525 IMMUNE SYSTEM STRUCTURE OF HUMAN ANTI - NICOTINE FAB FRAGMENT IN COMPLEX WITH NICOTINE - 11 - YL - METHYL - (4 - ETHYLAMINO - 4 - OXO) - BUTANOATE WITH NICOTINE - 11 - YL - METHYL - (4 - ETHYLAMINO - 4 - OXO) - BUTANOATE ? ? HOMO SAPIENS 13 SGSSSNIGSNYVY 7 RNNQRPS 11 AAWDDSLSAWV 1 G 16 SIYSSGSTYYNPSLKS 13 WFGDLLSLKGVEL crystal 2.10A 21.66% FAB 27-MAY-11 20110527 IMMUNE SYSTEM CRYSTAL STRUCTURE OF INHIBITORY ANTI - ACHE FAB408 ? ? ? MUS MUSCULUS 11 RTSENIDSYLA 7 AATNLAD 9 QHYSTTPWT 5 GYYMN 17 EMSPSTGRTTYNQNFKA 15 SVPLTTLIEDWYFDV crystal 1.90A 20.94% FAB 10-OCT-12 20121010 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MENINGOCOCCAL VACCINE ANTIGEN FACTOR H BINDING PROTEIN IN COMPLEX WITH A BACTERICIDAL ANTIBODY MOLECULE: LIPOPROTEIN; SYNONYM: LIPOPROTEIN GNA1870, FACTOR H BINDING PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDIHNYLN 7 RANRLVD 9 LQYDEFPPT 5 DYNMS 17 IIDPKYGTINYNQKFKG 10 DYYGSSYFDY crystal 1.80A 18.34% FAB 01-NOV-12 20121101 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HUMANIZED HYHEL - 10 FV MUTANT (HQ39KW47Y) - HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, GAL D IV; EC: 3.2.1.17 ? ? HOMO SAPIENS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.40A 21.80% FV 03-APR-07 20070403 IMMUNE SYSTEM STRUCTURE OF NEW ANTIGEN RECEPTOR VARIABLE DOMAIN FROM SHARKS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ORECTOLOBUS MACULATUS; ORGANISM_COMMON: SPOTTED WOBBEGONG; ORGANISM_TAXID: 168098; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: TG1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PGC 0 0 0 0 0 0 crystal 2.71A 18.90% NAR 23-APR-07 20070423 IMMUNE SYSTEM STRUCTURE OF NEW ANTIGEN RECEPTOR VARIABLE DOMAIN FROM SHARKS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ORECTOLOBUS MACULATUS; ORGANISM_COMMON: SPOTTED WOBBEGONG; ORGANISM_TAXID: 168098; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: TG1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PGC Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.21A 18.90% NAR 23-APR-07 20070423 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MURINE ANTIBODY FAB 528 ? ? ? MUS MUSCULUS 16 RSSQNIVHNNGITYLE 7 KVSDRFS 9 FQGSHIPPT 5 SYWMH 17 NIYPGSGGTNYAEKFKN 9 SGGPYFFDY crystal 2.30A 19.10% FAB 22-JUN-07 20070622 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - CIGUATOXIN ANTIBODY 10C9 ? ? ? MUS MUSCULUS 10 SASSSVSSVH 7 DTSKLPS 9 QQWSSNPPT 6 SGYNWH 16 YIHYRGTTNYNTSLKS 7 DDFYSDY crystal 2.60A 22.00% FAB 14-SEP-07 20070914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - CIGUATOXIN ANTIBODY 10C9 IN COMPLEX WITH CTX3C_ABCDE WITH CTX3C_ABCDE ? ? MUS MUSCULUS 10 SASSSVSSVH 7 DTSKLPS 9 QQWSSNPPT 6 SGYNWH 16 YIHYRGTTNYNTSLKS 7 DDFYSDY crystal 2.30A 22.80% FAB 14-SEP-07 20070914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - CIGUATOXIN ANTIBODY 10C9 IN COMPLEX WITH CTX3C - ABCD WITH CTX3C - ABCD ? ? MUS MUSCULUS 17 SGGASVVCFLPKDINVK 0 11 EATIVKSFNRN 6 SGYNWH 16 YIHYRGTTNYNTSLKS 7 DDFYSDY crystal 2.40A 29.70% FAB 14-SEP-07 20070914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN PROSTATE SPECIFIC ANTIGEN COMPLEXED WITH AN ACTIVATING ANTIBODY MOLECULE: PROSTATE - SPECIFIC ANTIGEN; FRAGMENT: UNP RESIDUES 25 - 261; SYNONYM: PSA, KALLIKREIN - 3, SEMENOGELASE, GAMMA - SEMINOPROTEIN, SEMININ, P - 30 ANTIGEN; EC: 3.4.21.77; ? ? MUS MUSCULUS 15 KASQSVDFDGDSYMN 7 AASNLAS 9 QQSNEDPYT 5 TYYIN 17 RIAPASGTTYSSEMFKD 13 ADYGFNSGEAMDY crystal 2.83A 20.70% FAB 08-NOV-07 20071108 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A TERNARY COMPLEX BETWEEN PSA, A SUBSTRAT - ACYL INTERMEDIATE AND AN ACTIVATING ANTIBODY MOLECULE: PROSTATE - SPECIFIC ANTIGEN; FRAGMENT: UNP RESIDUES 25 - 261; SYNONYM: PSA, KALLIKREIN - 3, SEMENOGELASE, GAMMA - SEMINOPROTEIN, SEMININ, P - 30 ANTIGEN; EC: 3.4.21.77; ? ? MUS MUSCULUS 15 KASQSVDFDGDSYMN 7 AASNLAS 9 QQSNEDPYT 5 TYYIN 17 RIAPASGTTYSSEMFKD 13 ADYGFNSGEAMDY crystal 3.10A 22.30% FAB 09-NOV-07 20071109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN PROSTATE SPECIFIC ANTIGEN COMPLEXED WITH AN ACTIVATING ANTIBODY MOLECULE: PROSTATE - SPECIFIC ANTIGEN; FRAGMENT: UNP RESIDUES 25 - 261; SYNONYM: PSA, KALLIKREIN - 3, SEMENOGELASE, GAMMA - SEMINOPROTEIN, SEMININ, P - 30 ANTIGEN; EC: 3.4.21.77; ? ? MUS MUSCULUS 15 KASQSVDFDGDSYMN 7 AASNLAS 9 QQSNEDPYT 5 TYYIN 17 RIAPASGTTYSSEMFKD 13 ADYGFNSGEAMDY crystal 3.25A 20.40% FAB 09-NOV-07 20071109 PROTEIN TRANSPORT / IMMUNE SYSTEM CRYSTAL STRUCTURE OF SECYE TRANSLOCON FROM THERMUS THERMOPHILUS WITH A FAB FRAGMENT MOLECULE: PREPROTEIN TRANSLOCASE SECY SUBUNIT; FRAGMENT: RESIDUES 1 - 434; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPWT 5 SYWIA 17 EILPGSGSTNYNEKFKG 10 SPYYYGNWDY crystal 3.20A 24.60% FAB 08-MAR-08 20080308 IMMUNE SYSTEM HUMAN THROMBOPOIETIN NEUTRALIZING ANTIBODY TN1 FAB ? ? ? HOMO SAPIENS 10 SASSSVSYMY 7 STSNLAS 9 QQRSGYPRT 5 DAWMD 19 EIRSKVNNHAIHYAESVKG 5 WSFLY crystal 2.04A 19.50% FAB 21-MAR-08 20080321 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF SCFV10 IN COMPLEX WITH HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? MUS MUSCULUS, UNIDENTIFIED Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.71A 19.60% scFv 02-MAY-08 20080502 IMMUNE SYSTEM / HYDROLASE 5 - FLUOROTRYPTOPHAN INCORPORATED SCFV10 COMPLEXED TO HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? MUS MUSCULUS, UNIDENTIFIED Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.30A 19.50% scFv 02-MAY-08 20080502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF P20.1 FAB FRAGMENT IN COMPLEX WITH ITS ANTIGEN PEPTIDE MOLECULE: PROTEINASE - ACTIVATED RECEPTOR 4; FRAGMENT: UNP RESIDUES 46 - 53; SYNONYM: PAR - 4, THROMBIN RECEPTOR - LIKE 3, COAGULATION FACTOR II RECEPTOR - LIKE 3; ENGINEERED: YES LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRVP 9 ALWYSNHWV 5 TAGMQ 17 WINTRSGVPKYAEDFKG 7 EGPGFVY crystal 1.80A 17.30% FAB 16-JUL-08 20080716 OXIDOREDUCTASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DSBB - FAB COMPLEX MOLECULE: DISULFIDE BOND FORMATION PROTEIN B; SYNONYM: DSBB, DISULFIDE OXIDOREDUCTASE; EC: 1.8.5. -; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLYT 5 SYDMS 17 YISSGGGSTYYPDTVKG 6 PDAMDY crystal 3.30A 27.90% FAB 28-OCT-08 20081028 IMMUNE SYSTEM STRUCTURE OF AN ACTIVITY SUPPRESSING FAB FRAGMENT TO CYTOCHROME P450 AROMATASE ? ? IGG1 MUS MUSCULUS 15 RASKSVSTSGYGYMH 7 LVSNLES 8 QHIREPLT 6 SDYAWN 16 YISYSGSTSYNPSLKS 10 GYYGSSHSPV crystal 3.00A 21.30% FAB 21-APR-99 19990421 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 5C8, FAB - INHIBITOR COMPLEX CATALYTIC ANTIBODY CATALYTIC ANTIBODY 5C8, FAB - INHIBITOR COMPLEX ? IGG MUS MUSCULUS 12 TASSSVSSSNLH 7 STSNLAS 9 HQYHRSPYT 5 DTYMH 17 QIDPANGNTKYDPKFQG 10 DPPYYGHGDY crystal 2.00A 20.60% FAB 18-MAR-98 19980318 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT LN31D COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGDNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 18.90% FV 24-AUG-09 20090824 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT LN32D COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNDLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 19.40% FV 28-AUG-09 20090828 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF HYHEL - 10 FV MUTANT LN92D COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D IV; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSDSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 18.60% FV 28-AUG-09 20090828 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMANIZED RECOMBINANT FAB FRAGMENT OF A MURINE; ANTIBODY ? ? ? HOMO SAPIENS 16 RSSQSIVHSNGHTYLE 7 QVSTRFS 9 FQASLVPLT 7 TSRVGVS 16 HIYWDDDKRYNPSLKS 15 RGFYGRKYEVNHFDY crystal 2.20A 21.20% FAB 28-NOV-09 20091128 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COMPLEX OF THE BACILLUS ANTHRACIS MAJOR SPORE SURFACE PROTEIN BCLA WITH SCFV ANTIBODY FRAGMENT MOLECULE: BCLA PROTEIN; FRAGMENT: UNP RESIDUES 311 - 445; SYNONYM: MAJOR SPORE SURFACE PROTEIN BCLA; ENGINEERED: YES; ? ? MUS MUSCULUS 10 CSARSSVSYM 7 YRTSNLA 10 CQQYHSYPPT 5 SYAMS 16 SISTGGDTHYQDSVKG 8 NRGWYFDV crystal 3.09A 20.00% FV 28-NOV-09 20091128 IMMUNE SYSTEM / RNA CRYSTAL STRUCTURE OF A HUMAN IGG - APTAMER COMPLEX ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; SYNTHETIC: YES 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.15A 23.70% FC 08-APR-10 20100408 IMMUNE SYSTEM PREDICTING AMINO ACID PREFERENCES IN THE COMPLEMENTARITY DETERMINING REGIONS OF AN ANTIBODY - ANTIGEN RECOGNITION INTERFACE ? ? ? HOMO SAPIENS 11 CRASQDVSTAV 7 YSASFLY 10 CQQHYTTPPT 3 STA 13 KLLIYSASFLYSG 26 QQHYTTPPTFGCGTKVEIEVQLVESG crystal 2.40A 21.80% scFv 16-FEB-11 20110216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FUCOSYLATED FC FRAGMENT FROM HUMAN IMMUNOGLOBULIN G1 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: DG44; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX2160 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.00A 18.80% FC 04-MAR-11 20110304 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NONFUCOSYLATED FC COMPLEXED WITH BIS - GLYCOSYLATED SOLUBLE FORM OF FC GAMMA RECEPTOR IIIA ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: MS704; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX2160; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX93 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 22.50% FC 28-APR-11 20110428 IMMUNE SYSTEM / TRANSFERASE CRYSTAL STRUCTURE OF ISOLATED DOMAIN III OF THE EXTRACELLULAR REGION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR IN COMPLEX WITH THE FAB FRAGMENT OF IMC - 11F8 MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: SEQUENCE DATABASE RESIDUES 335 - 538; SYNONYM: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 HQYGSTPLT 7 SGDYYWS 16 YIYYSGSTDYNPSLKS 11 VSIFGVGTFDY crystal 2.58A 23.00% FAB 19-OCT-07 20071019 IMMUNE SYSTEM / TRANSFERASE CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR IN COMPLEX WITH THE FAB FRAGMENT OF IMC - 11F8 MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: EXTRACELLULAR DOMAIN; SYNONYM: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 HQYGSTPLT 7 SGDYYWS 16 YIYYSGSTDYNPSLKS 11 VSIFGVGTFDY crystal 3.30A 28.60% FAB 19-OCT-07 20071019 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE UNSTABLE AND HIGHLY FIBRILLOGENIC PRO7SER MUTANT OF THE RECOMBINANT VARIABLE DOMAIN 6AJL2 MOLECULE: AMYLOID LAMBDA 6 LIGHT CHAIN VARIABLE REGION PIP; FRAGMENT: RESIDUES 1 - 111; ENGINEERED: YES; MUTATION: YES LAMBDA ? HOMO SAPIENS 13 TRSSGSIASNYVQ 7 EDNQRPS 12 YCQSYDSSNHVV 0 N/A 0 N/A 0 N/A crystal 1.90A 16.80% LC-dimer 25-OCT-07 20071025 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CD8ALPHA - BETA IN COMPLEX WITH YTS 156.7 FAB MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN; FRAGMENT: IG - LIKE V - TYPE DOMAIN; SYNONYM: T - CELL SURFACE GLYCOPROTEIN LYT - 3, T - CELL MEMBRANE GLYCOPROTEIN LY - 3, LYMPHOCYTE ANTIGEN 3, CD8B ANTIGEN; ENGINEERED: YES ? ? RATTUS RATTUS 11 QASQNIDKYIA 7 YTSTLVS 8 LQYDTLYT 5 SDSVH 16 GIWADGSTEYNSALKS 9 NRESYYFDY crystal 2.70A 23.80% FAB 05-NOV-07 20071105 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN AUTONOMOUS VH DOMAIN MOLECULE: HEAVY CHAIN VARIABLE DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 DTYIG 17 SIYPTNGYTRYADSVKG 8 WGGYAMDY crystal 1.80A 15.70% HC-dimer 06-NOV-07 20071106 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB WO2 BOUND TO THE N TERMINAL DOMAIN OF AMYLOID BETA PEPTIDE (1 - 28) MOLECULE: AMYLOID BETA PEPTIDE; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGHTYLE 7 QVSTRFS 9 FQASLVPLT 7 TSKVGVS 16 HIYWDDDKRYNPSLES 15 RGFYGRKYEVNHFDY crystal 1.59A 20.90% FAB 07-NOV-07 20071107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SINGLE DOMAIN VL OF AN ANTI - DNA BINDING ANTIBODY 3D8 SCFV AND ITS ACTIVE SITE REVEALED BY COMPLEX STRUCTURES OF A SMALL MOLECULE AND METALS STRUCTURES OF A SMALL MOLECULE AND METALS ? ? MUS MUSCULUS 17 KSSQSLFNSRTRKNYLA 7 WASTRES 9 KQSYYHMYT 0 N/A 0 N/A 0 N/A crystal 1.60A 22.90% LC-dimer 14-NOV-07 20071114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SINGLE DOMAIN VL OF AN ANTI - DNA BINDING ANTIBODY 3D8 SCFV AND ITS ACTIVE SITE REVEALED BY COMPLEX STRUCTURES OF A SMALL MOLECULE AND METALS STRUCTURES OF A SMALL MOLECULE AND METALS ? ? MUS MUSCULUS 17 KSSQSLFNSRTRKNYLA 7 WASTRES 5 KQSYT 0 N/A 0 N/A 0 N/A crystal 2.40A 21.30% LC-dimer 14-NOV-07 20071114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SINGLE DOMAIN VL OF AN ANTI - DNA BINDING ANTIBODY 3D8 SCFV AND ITS ACTIVE SITE REVEALED BY COMPLEX STRUCTURES OF A SMALL MOLECULE AND METALS STRUCTURES OF A SMALL MOLECULE AND METALS ? ? MUS MUSCULUS 17 KSSQSLFNSRTRKNYLA 7 WASTRES 9 KQSYYHMYT 0 N/A 0 N/A 0 N/A crystal 2.00A 22.40% LC-dimer 14-NOV-07 20071114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE UNSTABLE AND HIGHLY FIBRILLOGENIC PRO7SER MUTANT OF THE RECOMBINANT VARIABLE DOMAIN 6AJL2 MOLECULE: AMYLOID LAMBDA 6 LIGHT CHAIN VARIABLE REGION PIP (FRAGMENT); FRAGMENT: RESIDUES 1 - 111; SYNONYM: RECOMBINANT LIGHT CHAIN VARIABLE DOMAIN; ENGINEERED: YES; MUTATION: YES LAMBDA ? HOMO SAPIENS 13 TRSSGSIASNYVQ 7 EDNQRPS 12 YCQSYDSSNHVV 0 N/A 0 N/A 0 N/A crystal 2.30A 20.50% LC-dimer 15-NOV-07 20071115 HORMONE DUAL SPECIFIC BH1 FAB IN COMPLEX WITH VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; FRAGMENT: SEQUENCE DATABASE RESIDUES 27 - 135; SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF; ENGINEERED: YES ? ? HOMO SAPIENS 15 RASQDIPRSISGYVA 7 WGSYLYS 9 QQHYTTPPT 5 KDTYI 17 ARIYPTNGYTRYADSVK 12 RWGGDGFYAMDY crystal 2.60A 19.70% FAB 15-NOV-07 20071115 TRANSFERASE DUAL SPECIFIC BH1 FAB IN COMPLEX WITH THE EXTRACELLULAR DOMAIN OF HER2 / ERBB - 2 MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; FRAGMENT: SEQUENCE DATABASE RESIDUES 23 - 646; SYNONYM: P185ERBB2, C - ERBB - 2, NEU PROTO - ONCOGENE, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2, MLN 19, CD340 ANTIGEN; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASQDIPRSISGYVA 7 WGSYLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.90A 22.20% FAB 15-NOV-07 20071115 VIRAL PROTEIN / IMMUNE SYSTEM X - RAY CRYSTAL STRUCTURE OF THE SARS CORONAVIRUS SPIKE RECEPTOR BINDING DOMAIN IN COMPLEX WITH F26G19 FAB MOLECULE: SPIKE PROTEIN S1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQEISGYLS 7 AASTLDS 9 LQYVSYPWT 5 TYRMH 17 AIYPGNSDTTYNQKFKD 12 EGIPQLLRTLDY crystal 3.00A 23.70% FAB 26-NOV-07 20071126 IMMUNOGLOBULIN LOC, A LAMBDA 1 TYPE LIGHT - CHAIN DIMER (BENCE - JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE MOLECULE: LOC - LAMBDA 1 TYPE LIGHT - CHAIN DIMER; SYNONYM: BENCE - JONES PROTEIN; OTHER_DETAILS: CRYSTALLIZED IN AMMONIUM SULFATE LAMBDA ? HOMO SAPIENS 13 SGSSSNIGENSVT 7 EDNSRAS 11 AAWDDSLDVAV 0 N/A 0 N/A 0 N/A crystal 2.30A 16.50% LC-dimer 26-MAY-95 19950526 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - AMYLOID BETA FAB WO2 (P21, FORMB) ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGHTYLE 7 QVSTRFS 9 FQASLVPLT 7 TSKVGVS 16 HIYWDDDKRYNPSLES 15 RGFYGRKYEVNHFDY crystal 1.90A 18.20% FAB 06-DEC-07 20071206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB WO2 BOUND TO THE N TERMINAL DOMAIN OF AMYLOID BETA PEPTIDE (1 - 16) MOLECULE: AMYLOID BETA PEPTIDE; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGHTYLE 7 QVSTRFS 9 FQASLVPLT 7 TSKVGVS 16 HIYWDDDKRYNPSLES 15 RGFYGRKYEVNHFDY crystal 1.59A 19.20% FAB 06-DEC-07 20071206 IMMUNE SYSTEM STRUCTURE OF ANTI - AMYLOID - BETA FAB WO2 (FORM A, P212121) ? KAPPA IGG2 MUS MUSCULUS 16 RSSQSIVHSNGHTYLE 7 QVSTRFS 9 FQASLVPLT 7 TSKVGVS 16 HIYWDDDKRYNPSLES 15 RGFYGRKYEVNHFDY crystal 1.60A 20.50% FAB 07-DEC-07 20071207 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CHIMERIC ANTIBODY C2H7 FAB IN COMPLEX WITH A CD20 PEPTIDE MOLECULE: B - LYMPHOCYTE ANTIGEN CD20; FRAGMENT: CD20 PEPTIDE, RESIDEUS 163 - 187; SYNONYM: MEMBRANE - SPANNING 4 - DOMAINS SUBFAMILY A MEMBER 1, B - LYMPHOCYTE SURFACE ANTIGEN B1, LEU - 16, BP35; ENGINEERED: YES ? ? HOMO SAPIENS, MUS MUSCULUS 10 RASSSVSYMH 7 APSNLAS 9 QQWSFNPPT 5 SYNMH 17 AIYPGNGDTSYNQKFKG 13 VVYYSNSYWYFDV crystal 2.61A 23.70% FAB 07-DEC-07 20071207 HYDROLASE CRYSTAL STRUCTURE OF MT - SP1 IN COMPLEX WITH FAB INHIBITOR E2 MOLECULE: MEMBRANE - TYPE SERINE PROTEASE 1; FRAGMENT: PEPTIDASE S1 DOMAIN; SYNONYM: SERINE PROTEASE 14, MATRIPTASE, SUPPRESSOR OF TUMORIGENICITY PROTEIN 14, MT - SP1, PROSTAMIN, SERINE PROTEASE TADG - 15, TUMOR - ASSOCIATED DIFFERENTIALLY - EXPRESSED GENE 15 PROTEIN; EC: 3.4.21.109; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQGISSYLA 7 AASSLQS 9 QQHGNLPYT 5 SYAMS 17 AISGSGGSTYYADSVKG 19 PYLTYPQRRGPQNVSPFDN crystal 2.17A 22.60% FAB 13-DEC-07 20071213 IMMUNE SYSTEM CO - CRYSTAL STRUCTURE OF S25 - 2 FAB IN COMPLEX WITH 5 - DEOXY - 4 - EPI - 2,3 - DEHYDRO KDO (4.8) KDO WITH 5 - DEOXY - 4 - EPI - 2,3 - DEHYDRO KDO (4.8) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.85A 22.60% FAB 18-DEC-07 20071218 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 2F5 FAB' - 3H6 FAB COMPLEX MOLECULE: 3H6 FAB LIGHT CHAIN; ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 18 RRGPTTLFGVPIVNAMDV crystal 3.00A 27.60% FAB 20-DEC-07 20071220 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE TRANSTHYRETIN - RETINOL BINDING PROTEIN - FAB COMPLEX MOLECULE: TRANSTHYRETIN; SYNONYM: PREALBUMIN, TBPA, TTR, ATTR; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQSNEDPYT 5 SYWMH 17 GVYPGDSHTSYNQKFKG 9 SGFDYGNED crystal 3.38A 23.90% FAB 27-DEC-07 20071227 IMMUNE SYSTEM STRUCTURE OF UROKINASE RECEPTOR, UROKINASE AND VITRONECTIN COMPLEX MOLECULE: VITRONECTIN; FRAGMENT: SOMETOMEDIN - B DOMAIN; SYNONYM: SERUM - SPREADING FACTOR, S - PROTEIN, V75; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 EISKLAS 8 QQWNYPFT 5 NFYIH 17 WIFHGSDNTEYNEKFKD 9 WGPHWYFDV crystal 2.50A 23.00% FAB 27-DEC-07 20071227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB F22 - 4 IN COMPLEX WITH A SHIGELLA FLEXNERI 2A O - AG DECASACCHARIDE WITH A SHIGELLA FLEXNERI 2A O - AG DECASACCHARIDE ? ? MUS MUSCULUS 16 RSSKSLLHSDGITYLY 7 HLSNLAS 9 AHNVELPRT 5 NYWMS 19 EIRLKSDNYATYYAESVKG 4 PMDY crystal 1.80A 17.70% FAB 17-JAN-08 20080117 IMMUNE SYSTEM CRYSTAL STRUCTURE THE FAB FRAGMENT OF MATUZUMAB / EMD72000 (FAB72000) ? ? ? HOMO SAPIENS, MUS MUSCULUS 8 SASVTYMY 7 DTSNLAS 9 QQWSSHIFT 0 17 EFNPSNGRTNYNEKFKS 12 RDYDYDGRYFDY crystal 2.15A 22.60% FAB 18-JAN-08 20080118 IMMUNE SYSTEM / TRANSFERASE CRYSTAL STRUCTURE THE FAB FRAGMENT OF MATUZUMAB (FAB72000) IN COMPLEX WITH DOMAIN III OF THE EXTRACELLULAR REGION OF EGFR MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: SEGFR DOMAIN III; SYNONYM: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS, MUS MUSCULUS 10 SASSSVTYMY 7 DTSNLAS 9 QQWSSHIFT 5 SHWMH 17 EFNPSNGRTNYNEKFKS 12 RDYDYAGRYFDY crystal 3.20A 24.50% FAB 18-JAN-08 20080118 IMMUNE SYSTEM ANTIBODY FAB FRAGMENT 447 - 52D IN COMPLEX WITH UG1033 PEPTIDE MOLECULE: ENVELOPE GLYCOPROTEIN; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 13 SGSSSNIGNNYVL 7 GNNKRPS 12 ATWDSGLSADWV 5 DVWLN 19 RIKSRTDGGTTDYAASVKG 20 DGFIMIRGVSEDYYYYYMDV crystal 2.10A 24.10% FAB 24-JAN-08 20080124 IMMUNE SYSTEM STRUCTURAL CHARACTERIZATION OF A HUMAN FC FRAGMENT ENGINEERED FOR LACK OF EFFECTOR FUNCTIONS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 21.90% FC 25-JAN-08 20080125 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL FAB F22 - 4 SPECIFIC FOR SHIGELLA FLEXNERI 2A O - AG ? ? ? MUS MUSCULUS 16 RSSKSLLHSDGITYLY 7 HLSNLAS 9 AHNVELPRT 2 MS 13 AEIRTYYAESVKG 4 PMDY crystal 2.00A 20.10% FAB 01-FEB-08 20080201 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB F22 - 4 IN COMPLEX WITH A SHIGELLA FLEXNERI 2A O - AG PENTADECASACCHARIDE WITH A SHIGELLA FLEXNERI 2A O - AG PENTADECASACCHARIDE ? ? MUS MUSCULUS 16 RSSKSLLHSDGITYLY 7 HLSNLAS 9 AHNVELPRT 5 NYWMS 19 EIRLKSDNYATYYAESVKG 4 PMDY crystal 1.80A 19.20% FAB 05-FEB-08 20080205 IMMUNE SYSTEM KI O18 / O8 N34I / Y87H IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN MOLECULE: LIGHT CHAIN AMYLOIDOGENIC; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 TCQASQDISNY 7 IYDASNL 11 HCQQYDNLPYT 0 N/A 0 N/A 0 N/A crystal 1.53A 19.10% LC-dimer 26-FEB-08 20080226 IMMUNE SYSTEM KI O18 / O8 Y87H IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN MOLECULE: IMMUGLOBULIN LIGHT CHAIN; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 TCQASQDISNY 7 IYDASNL 11 HCQQYDNLPYT 0 N/A 0 N/A 0 N/A crystal 1.53A 19.10% LC-dimer 26-FEB-08 20080226 IMMUNE SYSTEM AL - 09 H87Y, IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN ? ? ? HOMO SAPIENS 11 CQASQDINNYL 7 YDASTLE 10 CQQYDNLPYT 0 N/A 0 N/A 0 N/A crystal 2.43A 19.30% LC-dimer 27-FEB-08 20080227 IMMUNE SYSTEM HIGH - RESOLUTION STRUCTURE OF BLUE FLUORESCENT ANTIBODY EP2 - 19G2 IN COMPLEX WITH STILBENE HAPTEN AT 100K WITH STILBENE HAPTEN AT 100K KAPPA ? MUS MUSCULUS 16 RSTKSLLHSNGITYLY 7 QMSNLAS 9 AQNLELPPT 5 RYIMS 16 SISSGGITYYPDSVKG 6 GQGRPY crystal 1.60A 18.70% FAB 03-MAR-08 20080303 IMMUNE SYSTEM HIGH - RESOLUTION STRUCTURE OF BLUE FLUORESCENT ANTIBODY EP2 - 19G2 ? KAPPA ? MUS MUSCULUS 16 RSTKSLLHSNGITYLY 7 QMSNLAS 9 AQNLELPPT 5 RYIMS 16 SISSGGITYYPDSVKG 6 GQGRPY crystal 1.70A 19.30% FAB 03-MAR-08 20080303 IMMUNE SYSTEM PURPLE - FLUORESCENT ANTIBODY EP2 - 25C10 IN COMPLEX WITH ITS STILBENE HAPTEN WITH ITS STILBENE HAPTEN KAPPA ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGTTLPPT 6 SDYAWN 16 YISYSGRIRYNPSLKR 11 SDYGNYGRGDY crystal 2.50A 21.20% FAB 03-MAR-08 20080303 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PURPLE - FLUORESCENT ANTIBODY EP2 - 25C10 ? KAPPA ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGTTLPPT 6 SDYAWN 16 YISYSGRIRYNPSLKR 11 SDYGNYGRGDY crystal 2.99A 21.30% FAB 03-MAR-08 20080303 PROTEIN TRANSPORT / IMMUNE SYSTEM NANOBODY - AIDED STRUCTURE DETERMINATION OF THE EPSI:EPSJ PSEUDOPILIN HETERDIMER FROM VIBRIO VULNIFICUS MOLECULE: TYPE II SECRETORY PATHWAY, PSEUDOPILIN EPSJ; FRAGMENT: UNP ENTRIES 47 - 210; SYNONYM: TYPE II SECRETORY PATHWAY, COMPONENT EPSJ; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 GYAMS 16 GINRDGSTSYTAPVKG 9 WLGGRDWYD crystal 2.58A 23.20% HC-dimer 03-MAR-08 20080303 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CATALYTIC ELIMINATION ANTIBODY 34E4, ORTHORHOMBIC CRYSTAL FORM FUSION PROTEIN OF THE VARIABLE DOMAIN (AUTHOR RESIDUES 1 - 105) AND THE CONSTANT DOMAIN (UNP RESIDUES 131 - 239); ? ? MUS MUSCULUS, HOMO SAPIENS 14 RSSSGAVTTSNYAT 7 GTNKRAP 9 ALWNSNHLV 5 RYWMT 17 EINPDSRTINYMPSLKD 14 LDFDVYNHYYVLDY crystal 2.60A 20.20% FAB 04-MAR-08 20080304 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CATALYTIC ELIMINATION ANTIBODY 34E4, TRICLINIC CRYSTAL FORM FUSION PROTEIN OF THE VARIABLE DOMAIN (AUTHOR RESIDUES 1 - 105) AND THE CONSTANT DOMAIN (UNP RESIDUES 131 - 239); ? ? MUS MUSCULUS, HOMO SAPIENS 14 RSSSGAVTTSNYAT 7 GTNKRAP 9 ALWNSNHLV 5 RYWMT 17 EINPDSRTINYMPSLKD 14 LDFDVYNHYYVLDY crystal 2.60A 22.20% FAB 04-MAR-08 20080304 IMMUNE SYSTEM SOLUTION STRUCTURE OF HUMAN SECRETORY IGA1 MOLECULE: SECRETORY COMPONENT; SYNONYM: POLY - IG RECEPTOR, PIGR, HEPATOCELLULAR CARCINOMA - ASSOCIATED PROTEIN TB6 KAPPA IGA HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 6 TSYGLH 17 GWISAGTGNTKYSQKFR 26 RDPYGGGKSEFDYWGQGTLVTVSSAS SolutionScattering N/A N/A ? 10-MAR-08 20080310 IMMUNE SYSTEM ANTI - ANTI - IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, COMPLEX WITH HUMAN ANGIOTENSIN II MOLECULE: PROTEIN (8 - MER; HUMAN ANGIOTENSIN II); KAPPA IGG1 MUS MUSCULUS 17 KSSQNLLHSITRKNYLA 7 WASTRGS 8 KQSYNLYT 5 TDAMN 19 RIRSKGFNFATYYADSVRD 9 GRDGEAMDY crystal 3.00A 20.00% FAB 14-JUN-99 19990614 IMMUNE SYSTEM HIV NEUTRALIZING MONOCLONAL ANTIBODY YZ23 ? ? ? MUS MUSCULUS 11 KASQNVGNIIA 7 LASYRYS 9 QQYSSFPLT 5 SYNMH 17 AIYPGNGDTSYNQKFKG 9 GRLSLGFDY crystal 2.50A 22.50% FAB 18-MAR-08 20080318 IMMUNE SYSTEM HIV NEUTRALIZING MONOCLONAL ANTIBODY YZ23 ? ? ? MUS MUSCULUS 11 KASQNVGNIIA 7 LASYRYS 9 QQYSSFPLT 5 SYNMH 17 AIYPGNGDTSYNQKFKG 9 GRLSLGFDY crystal 2.00A 22.00% FAB 18-MAR-08 20080318 IMMUNE SYSTEM SOLUTION STRUCTURE OF HUMAN SIGA2 MOLECULE: SECRETORY COMPONENT; SYNONYM: POLY - IG RECEPTOR, PIGR, HEPATOCELLULAR CARCINOMA - ASSOCIATED PROTEIN TB6 KAPPA ? HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 6 TSYGLH 17 GWISAGTGNTKYSQKFR 26 RDPYGGGKSEFDYWGQGTLVTVSSAS SolutionScattering N/A N/A ? 21-MAR-08 20080321 IMMUNE SYSTEM HIV NEUTRALIZING MONOCLONAL ANTIBODY YZ18 ? ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLQS 8 QQYSKLFT 5 SYWMH 17 AIYPGNSDTSYNQKFKG 14 WPHYYGGSRYYFDY crystal 2.30A 24.80% FAB 24-MAR-08 20080324 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF THE TRIMERIC PREFUSION EBOLA VIRUS GLYCOPROTEIN IN COMPLEX WITH A NEUTRALIZING ANTIBODY FROM A HUMAN SURVIVOR MOLECULE: ENVELOPE GLYCOPROTEIN GP1; FRAGMENT: DELETION OF RESIDUES 312 - 463; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: WEAK OR DISCONTINUOUS ELECTRON DENSITY IS OBSERVED IN THE OUTER REGIONS OF THE GLYCOPROTEIN (RESIDUES 268 - 278 AND 299 - 310) AND THESE RESIDUES ARE TENTATIVELY ASSIGNED; ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKSYLA 7 WASTRES 9 QQYYSAPLT 4 NYRN 17 SISSSSSYIHYADSVKG 15 EGPRATGYSADVFDI crystal 3.40A 26.30% FAB 10-APR-08 20080410 IMMUNE SYSTEM HOW TCR - LIKE ANTIBODY RECOGNIZES MHC - BOUND PEPTIDE MOLECULE: BETA - 2 - MICROGLOBULIN; ? ? MUS MUSCULUS 11 KASEDIYNRLA 7 GATSLET 9 QQYWSTPLT 5 DYNMD 17 DINPNNGGTIYNQKFKG 12 KPYYGNFAWFAY crystal 2.90A 22.30% ? 18-APR-08 20080418 IMMUNE SYSTEM HOW TCR - LIKE ANTIBODY RECOGNIZES MHC - BOUND PEPTIDE MOLECULE: 25 - D1.16 HEAVY CHAIN; ? ? MUS MUSCULUS 11 KASEDIYNRLA 7 GATSLET 9 QQYWSTPLT 5 DYNMD 17 DINPNNGGTIYNQKFKG 12 KPYYGNFAWFAY crystal 1.80A 21.90% FAB 18-APR-08 20080418 OXIDOREDUCTASE STRUCTURE OF COMPLEX III WITH BOUND CYTOCHROME C IN REDUCED STATE AND DEFINITION OF A MINIMAL CORE INTERFACE FOR ELECTRON TRANSFER. MOLECULE: CYTOCHROME B - C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL; SYNONYM: UBIQUINOL - CYTOCHROME - C REDUCTASE COMPLEX CORE PROTEIN 2, CORE PROTEIN II, COMPLEX III SUBUNIT 2; EC: 1.10.2.2; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 1.90A 24.50% FV 23-APR-08 20080423 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - OSTEOPONTIN ANTIBODY 23C3 IN COMPLEX WITH ITS EPITOPE PEPTIDE MOLECULE: A PEPTIDE FROM OSTEOPONTIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASENIYSFLA 7 AATNLAD 9 QHFWGTPFT 5 IYAMN 19 RIRSQSNNYTTYYADSVKD 5 QMGDY crystal 2.80A 25.10% FAB 24-APR-08 20080424 OXIDOREDUCTASE STRUCTURE OF YEAST COMPLEX III WITH ISOFORM - 2 CYTOCHROME C BOUND AND DEFINITION OF A MINIMAL CORE INTERFACE FOR ELECTRON TRANSFER. MOLECULE: CYTOCHROME B - C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL; SYNONYM: UBIQUINOL - CYTOCHROME - C REDUCTASE COMPLEX CORE PROTEIN 2, CORE PROTEIN II, COMPLEX III SUBUNIT 2; EC: 1.10.2.2; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 2.50A 22.50% FV 24-APR-08 20080424 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 BROADLY NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH THE GP41 FP - MPER HYB3K CONSTRUCT 514GIGALFLGFLGAAGS528KK - AHX - 655KNEQELLELDKWASLWN671 MOLECULE: HYB3K PEPTIDE CONSTRUCT; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 15 RRGPTARGPVNAMDV crystal 2.35A 21.10% ? 01-MAY-08 20080501 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE LLELDKWASLW MOLECULE: GP41 PEPTIDE LLELDKWASLW; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.05A 21.80% FAB 02-MAY-08 20080502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF AN ANTI - FACTOR IX ANTIBODY 10C12 ? ? ? HOMO SAPIENS 13 SGSTSNIGNNYVS 7 DVSKRPS 11 AAWDDSLSEFL 5 TYAMH 17 IISYDGSKKYYADSVKG 11 ASIAAARVLDY crystal 3.77A 24.90% FAB 19-MAY-08 20080519 IMMUNE SYSTEM FC FRAGMENT OF IGG1 (HERCEPTIN) WITH PROTEIN - A MIMETIC PEPTIDE DENDRIMER LIGAND. ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; STRAIN: HUMAN; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL: CHO 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 19.00% FC 19-MAY-08 20080519 IMMUNE SYSTEM / CYTOKINE CRYSTAL STRUCTURE OF IL - 23 IN COMPLEX WITH NEUTRALIZING FAB MOLECULE: INTERLEUKIN - 23 SUBUNIT P19; FRAGMENT: SUBUNIT P19; SYNONYM: INTERLEUKIN - 23 SUBUNIT ALPHA; IL - 23 SUBUNIT ALPHA; IL - 23P19; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISDYLH 7 YASQSIS 9 QNGHSFPFT 5 SNVMH 17 YINPYNDGTKYNEKFKG 6 NWDVAY crystal 1.90A 17.20% FAB 22-MAY-08 20080522 HYDROLASE / IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE STRUCTURE OF HYHEL10 FAB COMPLEXED TO HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D 4, ALLERGEN GAL D IV; EC: 3.2.1.17; ? ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.20A 19.10% FAB 27-MAY-08 20080527 MEMBRANE PROTEIN STRUCTURE OF THE E148A, Y445A DOUBLY UNGATED MUTANT OF E.COLI CLC_EC1, CL - / H+ ANTIPORTER MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.80A 100.00% FAB 10-JUN-08 20080610 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FABOX108 ? ? ? HOMO SAPIENS 15 RASKSVSTSGYSYMH 7 LASNLES 8 QHSRELLT 5 SYVMH 17 YINPYNDDTNYNEKFKG 10 EDYYGSRWGY crystal 2.30A 19.00% FAB 13-JUN-08 20080613 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FABOX117 ? ? ? HOMO SAPIENS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSTPWT 5 SYYIH 17 WVFPGSGNTKYNEKFKG 10 GNYDRAWFAY crystal 2.40A 22.20% FAB 20-JUN-08 20080620 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ISOLATED, UNGLYCOSYLATED ANTIBODY CH2 DOMAIN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: TG1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PCOMB3X Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.75A 20.30% ? 22-JUN-08 20080622 IMMUNE SYSTEM ENZYME DEGLYCOSYLATED HUMAN IGG1 FC FRAGMENT ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: MAN; ORGANISM_TAXID: 9606; GENE: IGHM; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_STRAIN: MOUSE NSO CELLS; OTHER_DETAILS: INTACT, HUMANIZED IGG1 MEDI-524 PRODUCED IN HYBRIDOMAS. FC FRAGMENT PRODUCED BY PAPAIN DIGESTION 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.84A 24.00% FC 02-JUL-08 20080702 IMMUNE SYSTEM HUMAN 1GG1 FC FRAGMENT, 2.5 ANGSTROM STRUCTURE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_STRAIN: MOUSE NSO CELLS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 28.00% FC 03-JUL-08 20080703 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELLELDKWASLWN GROWN IN AMMONIUM SULFATE MOLECULE: ELLELDKWASLWN GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 13 RRGPTGPVNAMDV crystal 3.90A 22.20% FAB 11-JUL-08 20080711 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 BROADLY NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH THE GP41 FP - MPER HYB3K CONSTRUCT 514GIGALFLGFLGAAGS528KK - AHX - 655KNEQELLELDKWASLWN671 SOAKED IN PEG / 2 - PROPANOL SOLUTION MOLECULE: GP41 PEPTIDE EPITOPE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 13 RRGPTGPVNAMDV crystal 2.00A 22.70% FAB 11-JUL-08 20080711 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 BROADLY NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH THE GP41 SCRAMBLEDFP - MPER SCRHYB3K CONSTRUCT GIGAFGLLGFLAAGSKK - AHX - K656NEQELLELDKWASLWN671 MOLECULE: SCRHYB3K CONSTRUCT; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 13 RRGPTGPVNAMDV crystal 3.30A 20.30% FAB 11-JUL-08 20080711 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - OSTEOPONTIN ANTIBODY 23C3 IN COMPLEX WITH W43A MUTATED EPITOPE PEPTIDE MOLECULE: A PEPTIDE FROM OSTEOPONTIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASENIYSFLA 7 AATNLAD 9 QHFWGTPFT 5 IYAMN 19 RIRSQSNNYTTYYADSVKD 5 QMGDY crystal 2.80A 24.40% FAB 12-JUL-08 20080712 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SAG173 - 04 MOLECULE: IG - LIKE PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFKSRNQKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 10 DGYYADAMDY crystal 1.86A 18.20% FV 17-JUL-08 20080717 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SAG506 - 01, ORTHORHOMBIC, TWINNED, CRYSTAL 1 MOLECULE: IG - LIKE PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFKSRNQKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTVEYSASVKG 10 DGYYVDAMDY crystal 1.95A 25.50% FV 17-JUL-08 20080717 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SAG506 - 01, ORTHORHOMBIC, TWINNED, CRYSTAL 2 MOLECULE: IG - LIKE PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFKSRNQKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTVEYSASVKG 10 DGYYVDAMDY crystal 1.95A 19.50% FV 17-JUL-08 20080717 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SAG506 - 01, TETRAGONAL, CRYSTAL 1 MOLECULE: IG - LIKE PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFKSRNQKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTVEYSASVKG 10 DGYYVDAMDY crystal 1.95A 27.20% FV 18-JUL-08 20080718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SAG506 - 01, TETRAGONAL, CRYSTAL 2 MOLECULE: IG - LIKE PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFKSRNQKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTVEYSASVKG 10 DGYYVDAMDY crystal 1.95A 23.30% FV 18-JUL-08 20080718 PROTEIN FIBRIL STRUCTURE OF AMYLOIDOGENIC KAPPA 1 BENCE JONES PROTEIN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: MUTANT OF VK1 O18/O8 GERMLINE; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET-12A 11 QASQDITNHLN 7 DASNLET 9 QEYDYLPQT 0 N/A 0 N/A 0 N/A crystal 1.80A 19.60% LC-dimer 18-JUL-08 20080718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF K63 - SPECIFIC FAB APU.3A8 BOUND TO K63 - LINKED DI - UBIQUITIN MOLECULE: UBIQUITIN D77; ENGINEERED: YES; MUTATION: YES; ? IGG1 HOMO SAPIENS 11 RASQSVSSAVA 7 SARSLYS 11 QQYSSYSSLFT 5 TGLIH 17 YITPYYGSTSYADSVKG 11 EYYRWYTAIDY crystal 2.60A 22.40% FAB 18-JUL-08 20080718 PROTEIN FIBRIL CRYSTAL STRUCTURE OF KAPPA 1 AMYLOIDOGENIC LIGHT CHAIN VARIABLE DOMAIN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: MUTANT OF VK1 O18/O8 GERMLINE; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21 GOLD (DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET12A 11 CQASQDISNYL 7 YDASNLE 11 CQQYHNLPPYT 0 N/A 0 N/A 0 N/A crystal 1.53A 19.10% LC-dimer 18-JUL-08 20080718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF K63 - SPECIFIC FAB APU2.16 BOUND TO K63 - LINKED DI - UBIQUITIN MOLECULE: UBIQUITIN D77; ENGINEERED: YES; MUTATION: YES; ? IGG1 HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 11 QQYSSYSSLFT 5 TGLIH 17 YISPYYGSTSYADSVKG 11 EYYRWYTAIDY crystal 2.70A 22.30% FAB 18-JUL-08 20080718 IMMUNE SYSTEM STRUCTURE OF CABBCII - 10 NANOBODY MOLECULE: CABBCII - 10; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 6 STFSLG 17 AIASMGGLTYYADSVKG 16 VRGYFMRLPSSHNFRY crystal 2.90A 24.50% HC-dimer 23-JUL-08 20080723 IMMUNE SYSTEM CRYSTAL STRUCTURE AND THERMODYNAMIC ANALYSIS OF DIAGNOSTIC FAB 106.3 COMPLEXED WITH BNP 5 - 13 (C10A) REVEAL BASIS OF SELECTIVE MOLECULAR RECOGNITION MOLECULE: BNP PEPTIDE EPITOPE; ENGINEERED: YES ? ? MUS MUSCULUS 15 KASQSVDYNGDSYLN 7 AASNLES 9 QQSNEDPFT 5 HYGIN 17 WINTHTGEPIYADDFKG 8 SHRFGLDY crystal 2.10A 18.80% FAB 20-AUG-08 20080820 IMMUNE SYSTEM NBBCII10 HUMANIZED (FGLA MUTANT) MOLECULE: NBBCII10 - FGLA; ENGINEERED: YES; MUTATION: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 7 SYSTFSL 17 AAIASMGGLTYYADSVK 17 AVRGYFMRLPSSHNFRY crystal 1.95A 21.50% HC-dimer 26-AUG-08 20080826 IMMUNE SYSTEM / HYDROLASE CABHUL6 FGLW MUTANT (HUMANIZED) IN COMPLEX WITH HUMAN LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; EC: 3.2.1.17; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 2 SG 17 AIRSSDGTTYYADSVKG 15 TEVAGWPLDIGIYDY crystal 1.85A 21.10% HC-dimer 27-AUG-08 20080827 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF KCSA MOLECULE: KCSA; ? ? MUS MUSCULUS 11 RASQSVSSAVA 7 SASSLYS 9 QQYSYSLLT 5 YSSMH 17 YISPSYGYTSYADSVKG 13 SWEAYWRWSAMDY crystal 2.60A 23.00% FAB 08-SEP-08 20080908 MEMBRANE PROTEIN THE CRYSTAL STRUCTURE OF FULL - LENGTH KCSA IN ITS CLOSED CONFORMATION MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 22 - 160 ? ? MUS MUSCULUS 11 RASQSVSSAVA 7 SASFLES 11 QQYYSYSAPVT 5 SYSIH 17 SISSYYSSTYYADSVKG 15 QPSYHMYSWWVALDY crystal 3.80A 27.00% FAB 08-SEP-08 20080908 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 BROADLY NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH THE GP41 SCRAMBLEDFP - MPER SCRHYB3K CONSTRUCT GIGAFGLLGFLAAGSKK - AHX - K656NEQELLELDKWASLWN671 SOAKED IN AMMONIUM SULFATE MOLECULE: GP41 SCRFP - MPER CONSTRUCT; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 13 RRGPTGPVNAMDV crystal 3.60A 23.50% FAB 11-SEP-08 20080911 OXIDOREDUCTASE / IMMUNE SYSTEM A D - PATHWAY MUTATION DECOUPLES THE PARACOCCUS DENITRIFICANS CYTOCHROME C OXIDASE BY ALTERING THE SIDE CHAIN ORIENTATION OF A DISTANT, CONSERVED GLUTAMATE MOLECULE: CYTOCHROME C OXIDASE SUBUNIT 2; SYNONYM: CYTOCHROME C OXIDASE POLYPEPTIDE II, CYTOCHROME AA3 SUBUNIT 2, OXIDASE AA (3) SUBUNIT 2; EC: 1.9.3.1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLGE 10 QHHYGTPPLT 5 SYTMS 17 SINNGGGRTYYPDTVKG 9 HEYYYAMDY crystal 2.32A 20.60% FV 12-SEP-08 20080912 IMMUNE SYSTEM / PROTON TRANSPORT STRUCTURE OF E203H MUTANT OF E.COLI CL - / H+ ANTIPORTER, CLC - EC1 MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1 H (+) / CL ( - ) EXCHANGE; CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.20A 24.60% FAB 18-SEP-08 20080918 IMMUNE SYSTEM / PROTON TRANSPORT STRUCTURE OF E203V MUTANT E.COLI CL - / H+ EXCHANGER, CLC - EC1 MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1 H (+) / CL ( - ) EXCHANGE; CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.90A 25.30% FAB 18-SEP-08 20080918 IMMUNE SYSTEM STRUCTURE OF THE TRANSFORMING GROWTH FACTOR - BETA NEUTRALIZING ANTIBODY GC - 1008 ? ? ? MUS MUSCULUS 12 RASQSLGSSYLA 7 GASSRAP 9 QQYADSPIT 5 SNVIS 17 GVIPIVDIANYAQRFKG 11 TLGLVLDAMDY crystal 1.75A 18.30% FAB 26-SEP-08 20080926 IMMUNE SYSTEM / CYTOKINE STRUCTURE OF THE FAB FRAGMENT OF GC - 1008 IN COMPLEX WITH TRANSFORMING GROWTH FACTOR - BETA 3 MOLECULE: TRANSFORMING GROWTH FACTOR BETA - 3; FRAGMENT: UNP RESIDUES 301 - 412, RECEPTOR BINDING FRAGMENT; SYNONYM: TGF - BETA - 3; ENGINEERED: YES ? ? MUS MUSCULUS 12 RASQSLGSSYLA 7 GASSRAP 9 QQYADSPIT 5 SNVIS 17 GVIPIVDIANYAQRFKG 11 TLGLVLDAMDY crystal 3.10A 25.50% FAB 26-SEP-08 20080926 IMMUNE SYSTEM CRYSTAL STRUCTURE THE FAB FRAGMENT OF EFALIZUMAB ? ? ? HOMO SAPIENS 11 RASKTISKYLA 7 SGSTLQS 9 QQHNEYPLT 5 GHWMN 17 MIHPSDSETRYNQKFKD 12 GIYFYGTTYFDY crystal 1.80A 19.10% FAB 26-SEP-08 20080926 IMMUNE SYSTEM / CELL ADHESION CRYSTAL STRUCTURE THE FAB FRAGMENT OF EFALIZUMAB IN COMPLEX WITH LFA - 1 I DOMAIN, FORM I MOLECULE: INTEGRIN ALPHA - L; FRAGMENT: I DOMAIN; SYNONYM: LEUKOCYTE ADHESION GLYCOPROTEIN LFA - 1 ALPHA CHAIN, LFA - 1A, LEUKOCYTE FUNCTION - ASSOCIATED MOLECULE 1 ALPHA CHAIN, CD11 ANTIGEN - LIKE FAMILY MEMBER A; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASKTISKYLA 7 SGSTLQS 9 QQHNEYPLT 5 GHWMN 17 MIHPSDSETRYNQKFKD 12 GIYFYGTTYFDY crystal 2.80A 22.70% FAB 26-SEP-08 20080926 IMMUNE SYSTEM / CELL ADHESION CRYSTAL STRUCTURE THE FAB FRAGMENT OF EFALIZUMAB IN COMPLEX WITH LFA - 1 I DOMAIN, FORM II MOLECULE: INTEGRIN ALPHA - L; FRAGMENT: I DOMAIN; SYNONYM: LEUKOCYTE ADHESION GLYCOPROTEIN LFA - 1 ALPHA CHAIN, LFA - 1A, LEUKOCYTE FUNCTION - ASSOCIATED MOLECULE 1 ALPHA CHAIN, CD11 ANTIGEN - LIKE FAMILY MEMBER A; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASKTISKYLA 7 SGSTLQS 9 QQHNEYPLT 5 GHWMN 17 MIHPSDSETRYNQKFKD 12 GIYFYGTTYFDY crystal 3.60A 26.70% FAB 26-SEP-08 20080926 IMMUNE SYSTEM CRYSTAL STRUCTURE OF LAC031, AN ENGINEERED ANTI - VLA1 FAB ? ? ? MUS MUSCULUS 12 SASSSVNSSALF 7 LTSNLAS 9 QQISGNPWT 5 RYTMS 16 TISGGGHTYYLDSVKG 10 GFGDGGYFDV crystal 1.90A 23.40% FAB 29-SEP-08 20080929 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTHRAX - NEUTRALIZING SINGLE - CHAIN ANTIBODY 14B7 ? ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.30A 21.60% scFv 06-OCT-08 20081006 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ENGINEERED NEUTRALIZING ANTIBODY M18 ? ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.00A 19.40% scFv 06-OCT-08 20081006 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ENGINEERED NEUTRALIZING ANTIBODY 1H ? ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.80A 21.70% scFv 07-OCT-08 20081007 IMMUNE SYSTEM / TOXIN CRYSTAL STRUCTURE OF THE ENGINEERED NEUTRALIZING ANTIBODY M18 COMPLEXED WITH ANTHRAX PROTECTIVE ANTIGEN DOMAIN 4 MOLECULE: ANTHRAX PROTECTIVE ANTIGEN; FRAGMENT: DOMAIN 4 OF PROTECTIVE ANTIGEN PA - 63: UNP RESIDUES 621 - 764; SYNONYM: PA, PA - 83, PA83, ANTHRAX TOXINS TRANSLOCATING PROTEIN [CONTAINS: PROTECTIVE ANTIGEN PA - 20 AND PROTECTIVE ANTIGEN PA - 63]; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 3.80A 23.20% scFv 07-OCT-08 20081007 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HUMAN CYTOMEGALOVIRUS ANTIBODY 8F9 PLUS GB PEPTIDE MOLECULE: SYNTHETIC PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 CRASQSVGGYL 7 FDASIRA 11 CQQRSMWPPVT 5 DHGIH 17 VISSDGTDERYTDSVKG 16 DGKCGGGRCYSGLLDY crystal 2.30A 21.00% FAB 20-OCT-08 20081020 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HUMAN CYTOMEGALOVIRUS ANTIBODY 8F9 MOLECULE: AD - 2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVGGYLT 7 DASIRAT 10 QQRSMWPPVT 5 DHGIH 17 VISSDGTDERYTDSVKG 10 DGKYSGLLDY crystal 2.50A 24.10% FAB 21-OCT-08 20081021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MJ5 FAB, A GERMLINE ANTIBODY VARIANT OF ANTI - HUMAN CYTOMEGALOVIRUS ANTIBODY 8F9 ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 10 QQRSNWPPIT 5 SYGMH 17 VISYDGSNKYYADSVKG 9 DGKSGLLDY crystal 2.40A 25.00% FAB 21-OCT-08 20081021 IMMUNE SYSTEM PFA1 FAB FRAGMENT COMPLEXED WITH PYRO - GLU3 - A - BETA (3 - 8) MOLECULE: PYRO - GLU3 - A - BETA (3 - 8) PEPTIDE; ENGINEERED: YES KAPPA ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDRSYNPSLKS 13 RAHTTVLGDWFAY crystal 1.95A 20.70% FAB 21-OCT-08 20081021 IMMUNE SYSTEM PFA1 FAB FRAGMENT COMPLEXED WITH ROR2 (518 - 525) MOLECULE: ROR2 (518 - 525) PEPTIDE; ENGINEERED: YES KAPPA ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVG 16 HIWWDDDRSYNPSLKS 13 RAHTTVLGDWFAY crystal 2.71A 18.00% FAB 21-OCT-08 20081021 IMMUNE SYSTEM ANTI - LEWIS Y FAB FRAGMENT WITH LEWIS Y ANTIGEN IN THE PRESENCE OF ZINC IONS ? ? ? MUS MUSCULUS, HOMO SAPIENS 16 RSSQRIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YMSNVGAITDYPDTVKG 10 GTRDGSWFAY crystal 2.50A 21.00% FAB 22-OCT-08 20081022 PROTEIN TRANSPORT CRYSTAL STRUCTURE OF THE N - TERMINAL DOMAIN OF THE SECRETIN GSPD FROM ETEC DETERMINED WITH THE ASSISTANCE OF A NANOBODY MOLECULE: GENERAL SECRETION PATHWAY PROTEIN GSPD; FRAGMENT: N - TERMINAL DOMAIN (UNP RESIDUES 40 - 277); ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INSMD 16 TITSGGSTNYADSVKG 12 NVKTWAGMTRDY crystal 2.80A 19.40% HC-dimer 22-OCT-08 20081022 IMMUNE SYSTEM GERMLINE V - GENES SCULPT THE BINDING SITE OF A FAMILY OF ANTIBODIES NEUTRALIZING HUMAN CYTOMEGALOVIRUS ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 10 QQRSNWPPWT 5 SYGMH 17 VISYDGSNKYYADSVKG 8 DGSGLLDY crystal 2.95A 30.00% FAB 27-OCT-08 20081027 IMMUNE SYSTEM IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 12 - RESIDUE CYCLIC PEPTIDE (INCLUDING RESIDUES 315 - 324 OF HIV - 1 GP120 (MN ISOLATE); H315S MUTATION MOLECULE: PROTEIN (CYCLIC PEPTIDE (GP120) ); FRAGMENT: RESIDUES 315 - 324 FROM HIV - 1 GP120; SYNONYM: V3 LOOP; ENGINEERED: YES; MUTATION: YES ? IGG1 MUS MUSCULUS 15 KASQGVDFDGASFMN 7 AASTLES 9 QQSHEDPLT 6 SGYSWH 16 YIHYSAGTNYNPSLKS 17 EEAMPYGNQAYYYAMDC crystal 2.80A 20.00% FAB 23-OCT-98 19981023 MEMBRANE PROTEIN / METAL TRANSPORT KCSA POTASSIUM CHANNEL IN THE OPEN - INACTIVATED STATE WITH 32 A OPENING AT T112 MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.30A 25.90% ? 04-NOV-08 20081104 MEMBRANE PROTEIN / METAL TRANSPORT KCSA POTASSIUM CHANNEL IN THE OPEN - INACTIVATED STATE WITH 23 A OPENING AT T112 MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.20A 25.90% FAB 10-NOV-08 20081110 MEMBRANE PROTEIN / METAL TRANSPORT KCSA POTASSIUM CHANNEL IN THE PARTIALLY OPEN STATE WITH 17 A OPENING AT T112 MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 21 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.40A 26.30% FAB 10-NOV-08 20081110 MEMBRANE PROTEIN / METAL TRANSPORT KCSA POTASSIUM CHANNEL IN THE PARTIALLY OPEN STATE WITH 14.5 A OPENING AT T112 MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 21 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.80A 24.30% FAB 18-NOV-08 20081118 MEMBRANE PROTEIN / METAL TRANSPORT KCSA POTASSIUM CHANNEL IN THE PARTIALLY OPEN STATE WITH 16 A OPENING AT T112 MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 21 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.00A 24.80% FAB 18-NOV-08 20081118 MEMBRANE PROTEIN / METAL TRANSPORT OPEN KCSA POTASSIUM CHANNEL IN THE PRESENCE OF RB+ ION MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 21 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.30A 24.10% FAB 18-NOV-08 20081118 MEMBRANE PROTEIN / METAL TRANSPORT KCSA POTASSIUM CHANNEL IN THE OPEN - CONDUCTIVE STATE WITH 20 A OPENING AT T112 IN THE PRESENCE OF RB+ ION MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 21 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.40A 28.40% FAB 18-NOV-08 20081118 IMMUNE SYSTEM MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN ? ? ? HOMO SAPIENS 11 KASQNVGTPVA 7 SASNRYT 9 QQYSSYPLT 5 SYWMH 17 MIDPNSGGTKYNEKFKS 5 RDMDY crystal 2.40A 20.60% FAB 13-JUN-99 19990613 IMMUNE SYSTEM / HORMONE STRUCTURE OF PARATHYROID HORMONE - RELATED PROTEIN COMPLEXED TO A NEUTRALIZING MONOCLONAL ANTIBODY MOLECULE: PARATHYROID HORMONE - RELATED PROTEIN; SYNONYM: PTH - RP, PTHRP; ENGINEERED: YES ? ? MUS MUSCULUS 12 TLSSQHSTYTIE 7 LKQDGSH 15 MYICGVGDTIKEQFV 5 SYGMS 17 TISSGGSYTYYPDSVKG 9 QTTMTYFAY crystal 2.00A 22.40% FAB 03-DEC-08 20081203 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMAN FC FRAGMENT ENGINEERED FOR EXTENDED SERUM HALF - LIFE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; STRAIN: HUMAN; GENE: IGG1, IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_CELL: HUMAN EMBRYONIC KIDNEY CELL LINE; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PABOE 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 23.00% FC 15-DEC-08 20081215 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF INFLUENZA HEMAGGLUTININ (H5) IN COMPLEX WITH A BROADLY NEUTRALIZING ANTIBODY F10 MOLECULE: HEMAGGLUTININ; FRAGMENT: HA2; SYNONYM: HEMAGGLUTININ HA2 CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 3.20A 23.50% scFv 17-DEC-08 20081217 IMMUNE SYSTEM STRUCTURE OF ROTAVIRUS OUTER CAPSID PROTEIN VP7 TRIMER IN COMPLEX WITH A NEUTRALIZING FAB MOLECULE: GLYCOPROTEIN VP7; FRAGMENT: TRIMER SUBUNIT; SYNONYM: SEROTYPE - SPECIFIC ANTIGEN, OUTER CAPSID GLYCOPROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 RPSENIYSYLA 7 KAKTLPE 9 QHHNGPPLT 5 SYWIE 17 EILPGSGSINYNEKFKG 12 NHGSPDFHVMDY crystal 3.40A 22.40% FAB 22-DEC-08 20081222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING HUMAN FAB Z13E1 IN COMPLEX WITH A 12 - RESIDUE PEPTIDE CONTAINING THE Z13E1 EPITOPE ON GP41 MOLECULE: ENVELOPE POLYPROTEIN GP160; FRAGMENT: TRANSMEMBRANE GLYCOPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVGRNLG 7 DASNRAT 9 QARLLLPQT 5 NYYWS 16 HIIYGGTTKYNPSLES 17 VAIGVSGFLNYYYYMDV crystal 1.80A 21.20% FAB 22-DEC-08 20081222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HAPTEN COMPLEX OF CATALYTIC ELIMINATION ANTIBODY 13G5 (WILD - TYPE) FUSION PROTEIN. THE VARIABLE DOMAIN (RESIDUES 1 - 107) IS FROM A MURINE SOURCE AND THE CONSTANT DOMAIN (RESIDUES 108 - 214) IS FROM A HUMAN SOURCE; KAPPA IGG2 MUS MUSCULUS, HOMO SAPIENS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHLPPT 5 NYGVD 16 VIWSGGSTNYNSALMS 13 HWGGYYIPYGMDH crystal 2.50A 22.20% FAB 27-DEC-08 20081227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HAPTEN COMPLEX OF CATALYTIC ELIMINATION ANTIBODY 13G5 (GLU (L39) ALA MUTANT) FUSION PROTEIN. THE VARIABLE DOMAIN (RESIDUES 1 - 107) IS FROM A MURINE SOURCE AND THE CONSTANT DOMAIN (RESIDUES 108 - 214) IS FROM A HUMAN SOURCE; KAPPA IGG2 MUS MUSCULUS, HOMO SAPIENS 16 RSSQSIVHSNGNTYLA 7 KVSNRFS 9 FQGSHLPPT 5 NYGVD 16 VIWSGGSTNYNSALMS 13 HWGGYYIPYGMDH crystal 2.20A 22.80% FAB 27-DEC-08 20081227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HAPTEN COMPLEX OF CATALYTIC ELIMINATION ANTIBODY 13G5 (GLU (L39) GLN MUTANT) FUSION PROTEIN. THE VARIABLE DOMAIN (RESIDUES 1 - 107) IS FROM A MURINE SOURCE AND THE CONSTANT DOMAIN (RESIDUES 108 - 214) IS FROM A HUMAN SOURCE; KAPPA IGG2 MUS MUSCULUS, HOMO SAPIENS 16 RSSQSIVHSNGNTYLQ 7 KVSNRFS 9 FQGSHLPPT 5 NYGVD 16 VIWSGGSTNYNSALMS 13 HWGGYYIPYGMDH crystal 2.18A 20.40% FAB 27-DEC-08 20081227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ALDOLASE ANTIBODY 33F12 FAB' IN COMPLEX WITH HAPTEN 1,3 - DIKETONE WITH HAPTEN 1,3 - DIKETONE ? IGG2 MUS MUSCULUS 16 RSSQSLVHSYGNTFLN 7 KVSNRFS 9 SQGTHVPYT 5 RFWMS 19 EIRLKSDNYATHYAESVKG 7 YFYSFSY crystal 1.90A 21.60% FAB 29-DEC-08 20081229 IMMUNE SYSTEM IGG1 FAB CHARACTERIZED BY H / D EXCHANGE ? ? IGG1 HOMO SAPIENS 11 RASQDIRYYLN 7 VASSLQS 9 LQVYSTPRT 7 FNNYYMD 17 RISSSGDPTWYADSVKG 7 LTTGSDS crystal 2.50A 21.30% FAB 26-JAN-09 20090126 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A THYROID - STIMULATING AUTOANTIBODY MOLECULE: THYROTROPIN RECEPTOR; FRAGMENT: LEUCINE RICH REPEAT DOMAIN (SEGMENT 22 - 260); SYNONYM: THYROID - STIMULATING HORMONE RECEPTOR, TSH - R; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGNSSNIGNNAVN 7 YDDQLPS 11 TSWDDSLDSQL 5 SYWIN 17 RIDPTDSYTNYSPSFKG 12 LEPGYSSTWSVN crystal 2.55A 18.40% FAB 27-JAN-09 20090127 IMMUNE SYSTEM ANTIBODIES SPECIFICALLY TARGETING A LOCALLY MISFOLDED REGION OF TUMOR ASSOCIATED EGFR MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 HSSQDINSNIG 7 HGTNLDD 9 VQYAQFPWT 6 SDFAWN 16 YISYSGNTRYNPSLKS 7 AGRGFPY crystal 2.00A 22.90% ? 05-FEB-09 20090205 IMMUNE SYSTEM ANTIBODIES SPECIFICALLY TARGETING A LOCALLY MISFOLDED REGION OF TUMOR ASSOCIATED EGFR MOLECULE: 806 LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HSSQDINSNIG 7 HGTNLDD 9 VQYAQFPWT 6 SDFAWN 16 YISYSGNTRYNPSLKS 7 AGRGFPY crystal 2.30A 22.80% ? 05-FEB-09 20090205 IMMUNE SYSTEM ANTIBODIES SPECIFICALLY TARGETING A LOCALLY MISFOLDED REGION OF TUMOR ASSOCIATED EGFR MOLECULE: EGFR PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 HSSQDISSNIG 7 HGTNLED 9 VQYGQFPWT 6 SDYAWN 16 YISYSANTRYNPSLKS 7 AGRGFPY crystal 1.59A 19.90% ? 05-FEB-09 20090205 IMMUNE SYSTEM ANTIBODIES SPECIFICALLY TARGETING A LOCALLY MISFOLDED REGION OF TUMOR ASSOCIATED EGFR MOLECULE: 175 LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQDIISNIG 7 HGTNLSD 9 VQYAQFPWT 6 SDFAWN 16 YISYSGNTRYNPSLKS 7 AGRGFPY crystal 2.60A 21.80% ? 05-FEB-09 20090205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 13 ANTIBODY CNTO607 ? ? ? HOMO SAPIENS 11 SGDNIGGTFVS 7 DDNDRPS 10 GTWDMVTNNV 5 SYWIN 17 GIAYDSSNTLYADSVKG 13 GLGAFHWDMQPDY crystal 2.10A 21.20% FAB 06-FEB-09 20090206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CNTO607 FAB AND IL - 13 MOLECULE: INTERLEUKIN - 13; FRAGMENT: UNP RESIDUES 21 - 132; SYNONYM: IL - 13; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDNIGGTFVS 7 DDNDRPS 10 GTWDMVTNNV 5 SYWIN 17 GIAYDSSNTLYADSVKG 13 GLGAFHWDMQPDY crystal 3.20A 21.30% FAB 06-FEB-09 20090206 IMMUNE SYSTEM C3B IN COMPLEX WITH A C3B SPECIFIC FAB MOLECULE: COMPLEMENT C3 ALPHA CHAIN; SYNONYM: COMPLEMENT C3, C3 AND PZP - LIKE ALPHA - 2 - MACROGLOBULIN DOMAIN - CONTAINING PROTEIN 1; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSYATLPT 5 SSSVS 17 LIYPYNGFNYYADSVKG 14 NALYGSGGYYAMDY crystal 3.10A 21.80% FAB 06-FEB-09 20090206 FLUORESCENT PROTEIN / IMMUNE SYSTEM GREEN FLUORESCENT PROTEIN BOUND TO MINIMIZER NANOBODY MOLECULE: GREEN FLUORESCENT PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 SYSMA 16 NILRDGTTTYAGSVKG 23 DSGTQLGYVGAVGLSCLDYVMDY crystal 1.61A 16.20% HC-dimer 13-FEB-09 20090213 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN LI+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.85A 23.90% FAB 18-FEB-09 20090218 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB CR6261 IN COMPLEX WITH A H5N1 INFLUENZA VIRUS HEMAGGLUTININ. MOLECULE: HEMAGGLUTININ; FRAGMENT: MEMBRANE FUSION DOMAIN, HA2; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS 13 SGSSSNIGNDYVS 7 DNNKRPS 10 ATWDRTAYVV 5 SYAIS 17 GIIPIFGTTKYAPKFQG 12 HMGYQVRETMDV crystal 2.70A 20.60% FAB 20-FEB-09 20090220 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB CR6261 IN COMPLEX WITH THE 1918 H1N1 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ; FRAGMENT: MEMBRANE FUSION DOMAIN, HA2; SYNONYM: HEMAGGLUTININ HA1 CHAIN, HEMAGGLUTININ HA2 CHAIN; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS 13 SGSSSNIGNDYVS 7 DNNKRPS 12 ATWDRRPTAYVV 5 SYAIS 17 GIIPIFGTTKYAPKFQG 12 HMGYQVRETMDV crystal 2.20A 20.70% FAB 20-FEB-09 20090220 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB F22 - 4 IN COMPLEX WITH A CARBOHYDRATE - MIMETIC PEPTIDE MOLECULE: PEPTIDE B1; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSKSLLHSDGITYLY 7 HLSNLAS 9 AHNVELPRT 5 NYWMS 19 EIRLKSDNYATYYAESVKG 4 PMDY crystal 1.70A 19.80% FAB 02-MAR-09 20090302 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 FAB 447 - 52D IN COMPLEX WITH V3 PEPTIDE W2RW020 MOLECULE: ENVELOPE GLYCOPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSSSNIGNNYVL 7 GNNKRPS 12 ATWDSGLSADWV 5 DVWLN 19 RIKSRTDGGTTDYAASVKG 20 DGFIMIRGVSEDYYYYYMDV crystal 2.25A 19.60% FAB 03-MAR-09 20090303 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 FAB 537 - 10D IN COMPLEX WITH V3 PEPTIDE MN MOLECULE: ENVELOPE GLYCOPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGTSTDVNGYNYVS 7 DVSKRPS 11 SSYTSSTPYVL 5 NYWMS 17 NIKQDGNDKYYVDSVKG 20 EFSSYTDHLEYYYDYYYMDV crystal 2.40A 18.70% FAB 03-MAR-09 20090303 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF APCT K158A TRANSPORTER BOUND TO 7F11 MONOCLONAL FAB FRAGMENT MOLECULE: UNCHARACTERIZED PROTEIN MJ0609; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 17 KSSQSLLNTSNQKNYLA 7 FASTRES 9 QQHYSTPYT 5 SYWMY 17 EIDPSDSYTNYNQNFKG 15 SPHYYGTTYNYPMDY crystal 2.59A 25.60% FAB 05-MAR-09 20090305 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF APCT TRANSPORTER BOUND TO 7F11 MONOCLONAL FAB FRAGMENT MOLECULE: UNCHARACTERIZED PROTEIN MJ0609; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLNTSNQKNYLA 7 FASTRES 9 QQHYSTPYT 5 SYWMY 17 EIDPSDSYTNYNQNFKG 15 SPHYYGTTYNYPMDY crystal 2.48A 25.00% FAB 05-MAR-09 20090305 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - CD20 ANTIBODY OFATUMUMAB ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWPIT 5 DYAMH 17 TISWNSGSIGYADSVKG 13 DIQYGNYYYGMDV crystal 2.20A 19.80% FAB 07-MAR-09 20090307 IMMUNE SYSTEM RATIONAL DEVELOPMENT OF HIGH - AFFINITY T - CELL RECEPTOR - LIKE ANTIBODIES ? ? ? HOMO SAPIENS 14 TGTSRDVGGYNYVS 7 DVIERSS 9 WSFAGSYYV 5 TYQMS 17 GIVSSGGSTAYADSVKG 10 ELLPYYGMDV crystal 2.30A 22.60% FAB 08-MAR-09 20090308 IMMUNE SYSTEM RATIONAL DEVELOPMENT OF HIGH - AFFINITY T - CELL RECEPTOR - LIKE ANTIBODIES MOLECULE: BETA - 2 - MICROGLOBULIN; SYNONYM: BETA - 2 - MICROGLOBULIN FORM PI 5.3; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSRDVGGYNYVS 7 DVIERSS 9 WSFAGSYYV 5 TYQMS 17 GIVSSGGSTAYADSVKG 10 ELLPYYGMDV crystal 1.90A 20.40% ? 08-MAR-09 20090308 IMMUNE SYSTEM X - RAY CRYSTAL STRUCTURE OF THE FAB FROM MAB 14, MOUSE ANTIBODY AGAINST CANINE PARVOVIRUS ? ? ? MUS MUSCULUS 11 KASQDVNTALA 7 SASNRYT 9 QQHYTTPWT 5 NYDMN 17 WIFPGDGSTRYNEKFKG 11 RGFHGSYSFAY crystal 2.00A 26.60% FAB 10-MAR-09 20090310 IMMUNE SYSTEM, ANTITUMOR PROTEIN CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF NIMOTUZUMAB. AN ANTI - EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY ? ? ? HOMO SAPIENS 16 RSSQNIVHSNGNTYLD 7 KVSNRFS 9 FQYSHVPWT 5 NYYIY 17 GINPTSGGSNFNEKFKT 14 QGLWFDSDGRGFDF crystal 2.50A 21.70% FAB 11-MAR-09 20090311 IMMUNE SYSTEM CRYSTAL STRUCTURES OF A THERAPEUTIC SINGLE CHAIN ANTIBODY IN COMPLEX METHAMPHETAMINE ? ? ? MUS MUSCULUS 17 SVTGDSVTSGYWSWIRQ 7 GSTYYNP 15 YCSYFDSDDYAMEYW 5 SGYWS 16 YISYRGSTYYNPSLKS 25 FDSDDYAMEYWGQGTSVTVSSGGGG crystal 1.90A 21.00% scFv 11-MAR-09 20090311 IMMUNE SYSTEM ANTI - METHAMPHETAMINE SINGLE CHAIN FV IN COMPLEX WITH MDMA ? ? ? MUS MUSCULUS 17 SVTGDSVTSGYWSWIRQ 7 GSTYYNP 15 YCSYFDSDDYAMEYW 5 SGYWS 16 YISYRGSTYYNPSLKS 26 FDSDDYAMEYWGQGTSVTVSGGGGSG crystal 2.40A 21.40% scFv 12-MAR-09 20090312 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF THE JAA - F11 MONOCLONAL ANTIBODY FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RSSQTIVYSNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 TYWMH 17 FISPNTDYTEYNQKFRD 9 SFIGYNFDF crystal 2.10A 18.90% FAB 17-MAR-09 20090317 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 FAB 268 - D IN COMPLEX WITH V3 PEPTIDE MN MOLECULE: ENVELOPE GLYCOPROTEIN GP160; SYNONYM: ENV POLYPROTEIN, SURFACE PROTEIN, SU, GLYCOPROTEIN 120, GP120, TRANSMEMBRANE PROTEIN, TM, GLYCOPROTEIN 41, GP41; ENGINEERED: YES ? ? HOMO SAPIENS 11 SAEALSNQYAY 7 KDTKRPS 10 QSADSSGDYV 5 NAYWT 16 YVYHTGVTNYNPSLKS 14 EWAEDGDFGNAFHV crystal 1.89A 19.20% FAB 18-MAR-09 20090318 TRANSFERASE / IMMUNE SYSTEM FGFR3 IN COMPLEX WITH A FAB MOLECULE: FIBROBLAST GROWTH FACTOR RECEPTOR 3; FRAGMENT: DOMAINS 2 AND 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSYTTPPT 5 STGIS 17 RIYPTNGSTNYADSVKG 18 TYGIYDLYVDYTEYVMDY crystal 2.10A 19.10% FAB 26-MAR-09 20090326 IMMUNE SYSTEM / ANTIMICROBIAL PROTEIN HEPCIDIN - FAB COMPLEX MOLECULE: HEPCIDIN; FRAGMENT: UNP RESIDUES 60 - 84; SYNONYM: LIVER - EXPRESSED ANTIMICROBIAL PEPTIDE, LEAP - 1, PUTATIVE LIVER TUMOR REGRESSOR, PLTR, HEPCIDIN - 25, HEPC25, HEPCIDIN - 20, HEPC20; ENGINEERED: YES ? ? HOMO SAPIENS 13 TRSSGSIASYYVQ 7 EDSQRPS 11 YCQSYDSSNVV 7 SNSAAWN 18 RTYYRSKWFNDYAVSVQS 10 GIVFSYAMDV crystal 1.89A 20.50% FAB 10-APR-09 20090410 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SINGLE - CHAIN FV (SCFV) FRAGMENT OF AN ANTI - ERBB2 ANTIBODY CHA21 IN COMPLEX WITH RESIDUES 1 - 192 OF ERBB2 EXTRACELLULAR DOMAIN MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; FRAGMENT: EXTRACELLULAR DOMAIN, UNP RESIDUES 23 - 214; SYNONYM: P185ERBB2, C - ERBB - 2, NEU PROTO - ONCOGENE, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2, MLN 19; EC: 2.7.10.1; ENGINEERED: YES; ? ? MUS MUSCULUS 17 MTCKSSQTLLYSNNQKN 7 LISWAFT 15 YYCQQYSNYPWTFGG 6 KSSQTL 19 QKPGQSPKLLISWAFTRKS 26 QQYSNYPWTFGGGTRLEIEVQLQQSG crystal 2.45A 20.30% scFv 16-APR-09 20090416 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV EPITOPE - SCAFFOLD 4E10 FV COMPLEX MOLECULE: 4E10_S0_1TJLC_004_N; ENGINEERED: YES; OTHER_DETAILS: THE AUTHOR STATES THAT THE EPITOPE - SCAFFOLD IS BASED ON TRANSCRIPTION FACTOR DKSA FROM E. COLI (PDB ID 1TJL) . ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 16 EGTTGWLGKPIGAFAH crystal 2.70A 23.20% FV 16-APR-09 20090416 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH FAB FROM LDLR COMPETITIVE ANTIBODY MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; FRAGMENT: UNP RESIDUES 153 - 692; SYNONYM: PROPROTEIN CONVERTASE PC9, SUBTILISIN / KEXIN - LIKE PROTEASE PC9, NEURAL APOPTOSIS - REGULATED CONVERTASE 1, NARC - 1; EC: 3.4.21. -; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GNSNRPS 11 QSYDSSLSGSV 5 SYSMN 17 SISSSSSYISYADSVKG 14 DYDFWSAYYDAFDV crystal 2.30A 19.10% FAB 17-APR-09 20090417 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE IGE - FC3 - 4 DOMAINS ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_STRAIN: HI5; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: RECOMBINANT BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PACGP67A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.23A 23.30% FC 30-APR-09 20090430 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE IGE - FC3 - 4 DOMAINS ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_STRAIN: HI5; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: RECOMBINANT BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PACGP67A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.45A 23.20% FC 30-APR-09 20090430 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE IGE - FC3 - 4 DOMAINS ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_STRAIN: HI5; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: RECOMBINANT BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PACGP67A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 24.30% FC 30-APR-09 20090430 IMMUNE SYSTEM RATIONAL DEVELOPMENT OF HIGH - AFFINITY T - CELL RECEPTOR - LIKE ANTIBODIES MOLECULE: BETA - 2 - MICROGLOBULIN; SYNONYM: BETA - 2 - MICROGLOBULIN FORM PI 5.3; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSRDVGGYNYVS 7 DVIIRPS 9 WSFAGSYYV 5 AYGMG 17 SIGSSGGGTAYADSVKG 10 ELLPYYGMDV crystal 2.90A 20.50% FAB 01-MAY-09 20090501 OXIDOREDUCTASE HIGH RESOLUTION CRYSTAL STRUCTURE OF PARACOCCUS DENITRIFICANS CYTOCHROME C OXIDASE MOLECULE: CYTOCHROME C OXIDASE SUBUNIT 2; SYNONYM: CYTOCHROME C OXIDASE POLYPEPTIDE II, CYTOCHROME AA3 SUBUNIT 2, OXIDASE AA (3) SUBUNIT 2; EC: 1.9.3.1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLGE 10 QHHYGTPPLT 5 SYTMS 17 SINNGGGRTYYPDTVKG 9 HEYYYAMDY crystal 2.25A 22.00% FV 04-MAY-09 20090504 IMMUNE SYSTEM BHA10 IGG1 WILD - TYPE FAB - ANTIBODY DIRECTED AT HUMAN LTBR ? ? IGG1 HOMO SAPIENS 11 KASQNVGINVA 7 SASYRYS 9 QQYDTYPFT 5 TYYLH 17 WIYPGNVHAQYNEKFKG 7 SWEGFPY crystal 1.90A 18.20% FAB 05-MAY-09 20090505 IMMUNE SYSTEM BHA10 IGG1 FAB DOUBLE MUTANT VARIANT - ANTIBODY DIRECTED AT HUMAN LTBR ? ? IGG1 HOMO SAPIENS 11 KASQNVGINVA 7 SASYRYS 9 QQYDTYPFT 5 TYYLH 17 WIYPGNVHAQYNEKFKG 7 SWEGFPY crystal 1.72A 16.00% FAB 05-MAY-09 20090505 IMMUNE SYSTEM BHA10 IGG1 FAB QUADRUPLE MUTANT VARIANT - ANTIBODY DIRECTED AT HUMAN LTBR ? ? IGG1 HOMO SAPIENS 11 KASQNVGINVA 7 SASYRYS 9 QQYDTYPFT 5 TYYLH 17 WIYPGNGHAQYNEKFKG 7 SWEGFDY crystal 1.62A 16.20% FAB 05-MAY-09 20090505 COMPLEX (ANTIBODY - ANTIGEN) STRUCTURE OF AN ANTIBODY - ANTIGEN COMPLEX. CRYSTAL STRUCTURE OF THE HY / HEL - 10 FAB - LYSOZYME COMPLEX MOLECULE: HEN EGG WHITE LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? IGG1 MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 3.00A 24.60% FAB 11-AUG-88 19880811 STRUCTURAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF HIV - 1 GP120 (CORE WITH V3) IN COMPLEX WITH CD4 - BINDING - SITE ANTIBODY F105 MOLECULE: GLYCOPROTEIN 120; SYNONYM: GP120, SU; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSRYLA 7 GASSRAT 9 QQYDNSVCT 5 SHYWS 16 YIYYSGSTNYSPSLKS 15 GPVPAVFYGDYRLDP crystal 2.90A 20.40% ? 18-MAY-09 20090518 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF AL - 57 ? ? ? HOMO SAPIENS 11 RASQSIGSYLN 7 AASSLQS 8 QQSYSTPS 5 RYVMW 17 YIWPSGGNTYYADSVKG 11 SYDFWSNAFDI crystal 2.50A 23.60% FAB 18-MAY-09 20090518 CELL ADHESION / IMMUNE SYSTEM CRYSTAL STRUCTURE OF INTERMEDIATE AFFINITY I DOMAIN OF INTEGRIN LFA - 1 WITH THE FAB FRAGMENT OF ITS ANTIBODY AL - 57 MOLECULE: INTEGRIN ALPHA - L; FRAGMENT: UNP RESIDUES 153 - 332; SYNONYM: LEUKOCYTE ADHESION GLYCOPROTEIN LFA - 1 ALPHA CHAIN, LFA - 1A, LEUKOCYTE FUNCTION - ASSOCIATED MOLECULE 1 ALPHA CHAIN, CD11 ANTIGEN - LIKE FAMILY MEMBER A; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQSIGSYLN 7 AASSLQS 8 QQSYSTPS 5 RYVMW 17 YIWPSGGNTYYADSVKG 11 SYDFWSNAFDI crystal 2.30A 17.30% FAB 19-MAY-09 20090519 IMMUNE SYSTEM MURINE UNGLYCOSYLATED IGG FC FRAGMENT ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGH-4, IGH; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 24.20% FC 23-MAY-09 20090523 IMMUNE SYSTEM CRYSTAL STRUCTURE OF USTEKINUMAB FAB ? ? ? HOMO SAPIENS 11 RASQGISSWLA 7 AASSLQS 9 QQYNIYPYT 5 TYWLG 17 IMSPVDSDIRYSPSFQG 10 RRPGQGYFDF crystal 3.00A 23.10% FAB 29-MAY-09 20090529 CYTOKINE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF USTEKINUMAB FAB / IL - 12 COMPLEX MOLECULE: INTERLEUKIN - 12 SUBUNIT ALPHA; SYNONYM: IL - 12A, IL - 12 SUBUNIT P35, CYTOTOXIC LYMPHOCYTE MATURATION FACTOR 35 KDA SUBUNIT, CLMF P35, NK CELL STIMULATORY FACTOR CHAIN 1, NKSF1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISSWLA 7 AASSLQS 9 QQYNIYPYT 5 TYWLG 17 IMSPVDSDIRYSPSFQG 10 RRPGQGYFDF crystal 3.00A 21.50% FAB 29-MAY-09 20090529 IMMUNE SYSTEM CS - 35 FAB COMPLEX WITH OLIGOARABINOFURANOSYL HEXASACCHARIDE WITH OLIGOARABINOFURANOSYL HEXASACCHARIDE ? ? MUS MUSCULUS 11 RASQDIGSYLN 7 YTSRLHS 9 HQDTKPPYT 5 NYWMH 17 SIYPGNSDTNYKQKFKG 9 FGNYVPFAY crystal 2.00A 17.20% FAB 01-JUN-09 20090601 IMMUNE SYSTEM CS - 35 FAB COMPLEX WITH A LINEAR, TERMINAL OLIGOARABINOFURANOSYL TETRASACCHARIDE FROM LIPOARABINOMANNAN WITH A LINEAR, TERMINAL OLIGOARABINOFURANOSYL TETRASACCHARIDE FROM LIPOARABINOMANNAN ? ? MUS MUSCULUS 11 RASQDIGSYLN 7 YTSRLHS 9 HQDTKPPYT 5 NYWMH 17 SIYPGNSDTNYKQKFKG 9 FGNYVPFAY crystal 1.80A 19.90% FAB 01-JUN-09 20090601 IMMUNE SYSTEM CS - 35 FAB COMPLEX WITH OLIGOARABINOFURANOSYL TETRASACCHARIDE (BRANCH PART OF HEXASACCHARIDE) WITH OLIGOARABINOFURANOSYL TETRASACCHARIDE (BRANCH PART OF HEXASACCHARIDE) ? ? MUS MUSCULUS 11 RASQDIGSYLN 7 YTSRLHS 9 HQDTKPPYT 5 NYWMH 17 SIYPGNSDTNYKQKFKG 9 FGNYVPFAY crystal 2.00A 17.70% FAB 01-JUN-09 20090601 IMMUNE SYSTEM / METAL TRANSPORT KCSA E71H - F103A MUTANT IN THE CLOSED STATE MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 1 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.20A 22.00% FAB 04-JUN-09 20090604 IMMUNE SYSTEM M1PRIME PEPTIDE FROM IGE BOUND BY HUMANIZED ANTIBODY 47H4 FAB MOLECULE: M1PRIME - DERIVED PEPTIDE; ENGINEERED: YES ? IGE MUS MUSCULUS 16 RSSQSLVHNNANTYLH 7 KVSNRFS 9 SQNTLVPWT 5 DYGIA 17 FISDLAYTIYYADTVTG 8 DNWDAMDY crystal 2.40A 21.40% FAB 08-JUN-09 20090608 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S73 - 2 ANTIBODY IN COMPLEX WITH ANTIGEN KDO (2.4) KDO WITH ANTIGEN KDO (2.4) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSSSVKG 15 DINPGSDGYYDALDY crystal 2.15A 21.70% FAB 23-JUN-09 20090623 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S73 - 2 ANTIBODY IN COMPLEX WITH ANTIGEN KDO WITH ANTIGEN KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSSSVKG 15 DINPGSDGYYDALDY crystal 1.80A 20.90% FAB 23-JUN-09 20090623 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S73 - 2 ANTIBODY IN COMPLEX WITH ANTIGEN KDO (2.8) KDO (2.4) KDO WITH ANTIGEN KDO (2.8) KDO (2.4) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSSSVKG 15 DINPGSDGYYDALDY crystal 1.90A 21.40% FAB 24-JUN-09 20090624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S73 - 2 ANTIBODY IN COMPLEX WITH ANTIGEN KDO (2.4) KDO (2.4) KDO WITH ANTIGEN KDO (2.4) KDO (2.4) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 15 DINPGSDGYYDALDY crystal 2.10A 21.90% FAB 24-JUN-09 20090624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S54 - 10 ANTIBODY IN COMPLEX WITH ANTIGEN KDO (2.4) KDO (2.4) KDO WITH ANTIGEN KDO (2.4) KDO (2.4) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKVKGYTIDYSASVKG 13 DMRRFDDGDAMDY crystal 2.60A 21.40% FAB 24-JUN-09 20090624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 23 ANTIBODY CNTO4088 MOLECULE: CNTO4088 LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASKSVSSSAYSFFH 7 LASNLQS 9 QHSGELPFT 5 TYAMH 19 RIRSKSHNYATDYADPVKD 9 EGIYGSFAY crystal 2.80A 19.80% FAB 29-JUN-09 20090629 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE WEST NILE VIRUS ENVELOPE GLYCOPROTEIN IN COMPLEX WITH THE E53 ANTIBODY FAB MOLECULE: ENVELOPE GLYCOPROTEIN; ENGINEERED: YES; KAPPA ? MUS MUSCULUS 10 SASSSVSYMH 7 ESSKLAS 9 QQWSSHPLT 5 DYYMT 19 FIGNKANDYTTEYSASVKG 10 VYGNYPYFDV crystal 3.00A 24.70% FAB 03-JUL-09 20090703 IMMUNE SYSTEM ANTIBODY STRUCTURE ? ? ? MUS MUSCULUS 11 QSSQDINKYIG 7 YTSILRP 9 LQYDDLLLT 5 DFEIH 17 TLDPETGGTAYNQNFKG 16 WGKKFYYYGTSYAMDY crystal 1.95A 18.10% ? 08-JUL-09 20090708 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE LT1009 (SONEPCIZUMAB) ANTIBODY FAB FRAGMENT IN COMPLEX WITH SPHINGOSINE - 1 - PHOSPHATE WITH SPHINGOSINE - 1 - PHOSPHATE ? ? MUS MUSCULUS 11 ITTTDIDDDMN 7 EGNILRP 9 LQSDNLPFT 5 DHTIH 17 AISPRHDITKYNEMFRG 12 GGFYGSTIWFDF crystal 1.90A 19.20% FAB 10-JUL-09 20090710 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ALDKWD MOLECULE: GP41 MPER PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 1.86A 22.40% FAB 21-JUL-09 20090721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 FAB' FRAGMENT IN COMPLEX WITH GP41 PEPTIDE ALDKWNQ MOLECULE: GP41 MPER PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 13 RRGPTGPVNAMDV crystal 2.10A 21.20% FAB 21-JUL-09 20090721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 FAB' FRAGMENT IN COMPLEX WITH GP41 PEPTIDE ANALOG ELD (ORN) WAS MOLECULE: GP41 MPER PEPTIDE ANALOG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 22.90% FAB 21-JUL-09 20090721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 FAB' FRAGMENT IN COMPLEX WITH GP41 PEPTIDE ANALOG ELD (NRG) WAS MOLECULE: GP41 MPER PEPTIDE ANALOG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.24A 22.90% FAB 21-JUL-09 20090721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 FAB' FRAGMENT IN COMPLEX WITH GP41 PEPTIDE ANALOG ELD (PAF) WAS MOLECULE: GP41 MPER PEPTIDE ANALOG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.25A 22.00% FAB 21-JUL-09 20090721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - GP120 CORE IN COMPLEX WITH CD4 - BINDING SITE ANTIBODY B13, SPACE GROUP C222 MOLECULE: HIV - 1 HXBC2 GP120 CORE; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 QASQDIRNYLN 7 DASNSET 10 QQHQNVPLTT 5 NYAMH 17 LIKYDGRNKYYADSVKG 19 DIGLKGEHYDILTAYGPDY crystal 2.50A 18.10% FAB 22-JUL-09 20090722 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - GP120 CORE IN COMPLEX WITH CD4 - BINDING SITE ANTIBODY B13, SPACE GROUP C2221 MOLECULE: HIV - 1 HXBC2 GP120 CORE; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 QASQDIRNYLN 7 DASNSET 10 QQHQNVPLTT 5 NYAMH 17 LIKYDGRNKYYADSVKG 19 DIGLKGEHYDILTAYGPDY crystal 3.20A 19.80% FAB 22-JUL-09 20090722 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 237MAB WITH ANTIGEN MOLECULE: PODOPLANIN; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 8 SQSTHVPT 5 DAWMD 19 EIRNKANNHETYYAESVKG 7 GKVRNAY crystal 2.20A 22.90% FAB 23-JUL-09 20090723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 237MAB IN COMPLEX WITH A GALNAC WITH A GALNAC ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 8 SQSTHVPT 5 DAWMD 19 EIRNKANNHETYYAESVKG 7 GKVRNAY crystal 2.39A 22.80% FAB 23-JUL-09 20090723 IMMUNE SYSTEM X - RAY STRUCTURE OF AMYLOID BETA PEPTIDE:ANTIBODY (ABETA1 - 7:12A11) COMPLEX MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: RESIDUES 672 - 678; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQSSHVPLT 7 TSGMSVG 16 HIWWDDDKYYNPSLKS 10 RTTTADYFAY crystal 1.50A 18.00% FAB 24-JUL-09 20090724 IMMUNE SYSTEM X - RAY STRUCTURE OF AMYLOID BETA PEPTIDE:ANTIBODY (ABETA1 - 40:12A11) COMPLEX MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: RESIDUES 672 - 711; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQSSHVPLT 7 TSGMSVG 16 HIWWDDDKYYNPSLKS 10 RTTTADYFAY crystal 1.50A 18.80% FAB 24-JUL-09 20090724 IMMUNE SYSTEM X - RAY STRUCTURE OF AMYLOID BETA PEPTIDE:ANTIBODY (ABETA1 - 7:10D5) COMPLEX MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: RESIDUES 672 - 678; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQNIIHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TSGMGVS 16 HIYWDDDKRYNPSLKS 13 RPITPVLVDAMDY crystal 2.15A 16.50% FAB 24-JUL-09 20090724 IMMUNE SYSTEM X - RAY STRUCTURE OF AMYLOID BETA PEPTIDE:ANTIBODY (ABETA1 - 7:12B4) COMPLEX MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: RESIDUES 672 - 678; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQNIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 7 TNGMGVS 16 HIYWDEDKRYNPSLKS 13 RRIIYDVEDYFDY crystal 2.95A 23.60% FAB 24-JUL-09 20090724 TRANSPORT PROTEIN POTASSIUM CHANNEL KCSA - FAB COMPLEX IN LI+ AND K+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.75A 24.20% FAB 27-JUL-09 20090727 IMMUNE SYSTEM STRUCTURE OF S67 - 27 IN COMPLEX WITH KO WITH KO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSNNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 15 DISPSYGVYYEGFAY crystal 2.10A 21.50% FAB 04-AUG-09 20090804 IMMUNE SYSTEM STRUCTURE OF S67 - 27 IN COMPLEX WITH TSBP WITH TSBP ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSNNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 15 DISPSYGVYYEGFAY crystal 2.55A 21.90% FAB 04-AUG-09 20090804 IMMUNE SYSTEM STRUCTURE OF S67 - 27 IN COMPLEX WITH KDO (2.8) KDO WITH KDO (2.8) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSNNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 15 DISPSYGVYYEGFAY crystal 2.85A 23.90% FAB 05-AUG-09 20090805 IMMUNE SYSTEM STRUCTURE OF S67 - 27 IN COMPLEX WITH KDO (2.8) - 7 - O - METHYL - KDO WITH KDO (2.8) - 7 - O - METHYL - KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSNNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 15 DISPSYGVYYEGFAY crystal 2.60A 23.80% FAB 05-AUG-09 20090805 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN UNBOUND KZ52 NEUTRALIZING ANTI - EBOLAVIRUS ANTIBODY. ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKSYLA 7 WASTRES 9 QQYYSAPLT 5 NYRMN 17 SISSSSSYIHYADSVKG 16 EGPRATGYSMADVFDI crystal 2.50A 20.50% FAB 12-AUG-09 20090812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THERAPEUTIC ANTIBODY BASILIXIMAB IN COMPLEX WITH IL - 2RA (CD25) ECTODOMAIN MOLECULE: INTERLEUKIN - 2 RECEPTOR ALPHA CHAIN; FRAGMENT: EXTRACELLULAR DOMAIN, ECTODOMAIN, UNP RESIDUES 22 - 238; SYNONYM: IL - 2 RECEPTOR ALPHA SUBUNIT, IL - 2 - RA, IL2 - RA, P55, TAC ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 10 SASSSRSYMQ 7 DTSKLAS 7 HQRSSYT 5 RYWMH 17 AIYPGNSDTSYNQKFEG 8 DYGYYFDF crystal 2.90A 21.70% FAB 29-AUG-09 20090829 IMMUNE SYSTEM ANTI NEUGCGM3 GANGLIOSIDE CHIMERIC ANTIBODY CHP3 ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSTPWT 5 RYSVH 16 MIWGGGSTDYNSALKS 11 SGVRAQAWFAY crystal 1.75A 19.60% FAB 29-AUG-09 20090829 IMMUNE SYSTEM / RNA CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF AN RNA POLYMERASE RIBOZYME COMPLEXED WITH AN ANTIGEN BINDING ANTIBODY FRAGMENT MOLECULE: CLASS I LIGASE PRODUCT; ENGINEERED: YES; OTHER_DETAILS: SYN ? ? MUS MUSCULUS 11 CRASQSVSSAV 7 YSASSLY 10 CQQSYSFPST 6 SYSSIH 17 ASISPYSGSTYYADSVK 14 RQGYRRRSGRGFDY crystal 3.10A 20.80% FAB 01-SEP-09 20090901 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOTAVIZUMAB FAB BOUND TO PEPTIDE EPITOPE MOLECULE: FUSION GLYCOPROTEIN F1; FRAGMENT: SEQUENCE DATABASE RESIDUES 254 - 277; SYNONYM: FUSION GLYCOPROTEIN F0, PROTEIN F ? ? MUS MUSCULUS 10 SASSRVGYMH 7 DTSKLAS 9 FQGSGYPFT 7 TAGMSVG 16 DIWWDDKKHYNPSLKD 10 DMIFNFYFDV crystal 2.75A 21.60% FAB 04-SEP-09 20090904 VIRUS THE PSEUDO - ATOMIC STRUCTURE OF WEST NILE IMMATURE VIRUS IN COMPLEX WITH FAB FRAGMENTS OF THE ANTI - FUSION LOOP ANTIBODY E53 MOLECULE: ENVELOPE PROTEIN E; FRAGMENT: WEST NILE VIRUS ENVELOPE PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 ESSKLAS 9 QQWSSHPLT 5 DYYMT 19 FIGNKANDYTTEYSASVKG 10 VYGNYPYFDV ElectronMicroscopy N/A N/A FAB 26-FEB-09 20090226 VIRUS THE PSEUDO - ATOMIC STRUCTURE OF DENGUE IMMATURE VIRUS IN COMPLEX WITH FAB FRAGMENTS OF THE ANTI - FUSION LOOP ANTIBODY E53 MOLECULE: ENVELOPE PROTEIN E; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 ESSKLAS 9 QQWSSHPLT 5 DYYMT 19 FIGNKANDYTTEYSASVKG 10 VYGNYPYFDV ElectronMicroscopy N/A N/A FAB 26-FEB-09 20090226 IMMUNE SYSTEM VARIABLE DOMAINS OF THE X - RAY STRUCTURE OF FAB 14 FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 14 COMPLEX IMMUNE SYSTEM VARIABLE DOMAINS OF THE X - RAY STRUCTURE OF FAB 14 FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 14 COMPLEX ? ? MUS MUSCULUS 11 KGSQDVNSALA 7 SGSNRYS 9 QQHYTTPWT 5 NYDMN 18 WIFPGDGSARGNEKFGGA 11 RGFAGAASFAY ElectronMicroscopy N/A N/A FAB 07-APR-09 20090407 IMMUNE SYSTEM VARIABLE DOMAINS OF THE WAM OF FAB B FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB B COMPLEX MOLECULE: FAB B, HEAVY CHAIN; ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_TAXID: 10116; MOL_ID: 2; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_TAXID: 10116 11 QASQNINKYIA 7 YTSTLVS 9 LQYDSSPRT 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 09-APR-09 20090409 IMMUNE SYSTEM VARIABLE DOMAINS OF THE COMPUTER GENERATED MODEL (WAM) OF FAB 6 FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 6 COMPLEX MOLECULE: ANTIBODY 6, HEAVY CHAIN; FRAGMENT: FRAGMENT OF ANTIBODY 6 ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090 11 RATKNIYSYLA 7 NAKTLTE 9 QHHYATPYT 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 09-APR-09 20090409 IMMUNE SYSTEM VARIABLE DOMAINS OF THE COMPUTER GENERATED MODEL (WAM) OF FAB 8 FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 8 COMPLEX IMMUNE SYSTEM VARIABLE DOMAINS OF THE COMPUTER GENERATED MODEL (WAM) OF FAB 8 FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 8 COMPLEX ? ? MUS MUSCULUS 15 KASQRVDYDGVSYMN 7 AASDLES 9 QQSNYDPWT 5 DYIMV 17 NINPYHGRTAYNLKFKG 11 KGYVEGGGLDY ElectronMicroscopy N/A N/A FAB 09-APR-09 20090409 IMMUNE SYSTEM VARIABLE DOMAINS OF THE COMPUTER GENERATED MODEL (WAM) OF FAB 15 FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 15 COMPLEX MOLECULE: FRAGMENT OF NEUTRALIZING ANTIBODY 15 (HEAVY CHAIN); ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090 15 KASQSVDYEGDSYMN 7 AASNLES 9 QQSNGDPYT 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 09-APR-09 20090409 IMMUNE SYSTEM VARIABLE DOMAINS OF THE MOUSE FAB (1AIF) FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 16 COMPLEX IMMUNE SYSTEM VARIABLE DOMAINS OF THE MOUSE FAB (1AIF) FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB 16 COMPLEX ? IGG2 MUS MUSCULUS 12 SVSSSISSSNLH 7 GTSNLAS 9 QQWNSYPYT 5 NYWMS 19 EIRLNSDNFATHYAESVKG 10 RPLFYYAVDY ElectronMicroscopy N/A N/A FAB 09-APR-09 20090409 IMMUNE SYSTEM VARIABLE DOMAINS OF THE COMPUTER GENERATED MODEL (WAM) OF FAB E FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB E COMPLEX IMMUNE SYSTEM VARIABLE DOMAINS OF THE COMPUTER GENERATED MODEL (WAM) OF FAB E FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB E COMPLEX ? ? RATTUS NORVEGICUS 11 KASQNVDSNVD 7 KASNRNT 9 MQSTSYPLT 5 SYHVH 16 VMWNDGDTSYNLALNS 14 PELPGLTYGVWFPY ElectronMicroscopy N/A N/A FAB 09-APR-09 20090409 IMMUNE SYSTEM VARIABLE DOMAINS OF THE COMPUTER GENERATED MODEL (WAM) OF FAB F FITTED INTO THE CRYOEM RECONSTRUCTION OF THE VIRUS - FAB F COMPLEX MOLECULE: FRAGMENT FROM NEUTRALIZING ANTIBODY F (HEAVY CHAIN); ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_TAXID: 10116; MOL_ID: 2; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_TAXID: 10116 11 KASHNINKNLE 7 YANNLQT 8 YQYNSGHT 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 09-APR-09 20090409 VIRUS WEST NILE VIRUS IN COMPLEX WITH FAB FRAGMENTS OF MAB CR4354 (FITTED COORDINATES OF ENVELOPE PROTEINS AND FAB FRAGMENTS OF ONE ICOSAHEDRAL ASU) MOLECULE: POLYPROTEIN; FRAGMENT: ECTODOMAIN OF VIRAL SURFACE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A FAB 18-JUN-10 20100618 VIRUS / IMMUNE SYSTEM STRUCTURE OF ADENO - ASSOCIATED VIRUS - 2 IN COMPLEX WITH NEUTRALIZING MONOCLONAL ANTIBODY A20 MOLECULE: CAPSID PROTEIN VP1; FRAGMENT: SEE REMARK 999; SYNONYM: COAT PROTEIN VP1 ? ? MUS MUSCULUS 11 KASEDIHNRLA 7 GATSLET 9 QQYWIGPFT 7 TSGYTWH 16 GYIHFSGYTNYNPSLK 11 RGDYGYEWFTY ElectronMicroscopy N/A N/A FAB 23-MAY-12 20120523 IMMUNE SYSTEM ELECTRON CRYO - MICROSCOPY OF CHIKUNGUNYA VLP IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB M242 WITH NEUTRALIZING ANTIBODY FAB M242 ? ? MUS MUSCULUS 15 RASESVDSYGNSFMN 7 RASNLES 9 QQSNEDPFT 5 SFYIY 17 WIFPGSTNTKYNEKFKG 8 VDGYAMDY ElectronMicroscopy N/A N/A FAB 28-JAN-13 20130128 IMMUNE SYSTEM ELECTRON CRYO - MICROSCOPY OF CHIKUNGUNYA VLP IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB 9.8B WITH NEUTRALIZING ANTIBODY FAB 9.8B ? ? MUS MUSCULUS 10 SASSSVTYMY 7 DTSNLAS 9 QQRTNYPLT 5 SKWMH 17 NIDPSDSETHYNQKFKD 9 GVTRGYFDV ElectronMicroscopy N/A N/A FAB 28-JAN-13 20130128 IMMUNE SYSTEM ELECTRON CRYO - MICROSCOPY OF CHIKUNGUNYA VLP IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB M10 WITH NEUTRALIZING ANTIBODY FAB M10 ? ? MUS MUSCULUS 10 SASSSVTYMY 7 DTSNLAS 9 QQRTNYPLT 5 SKWMH 17 NIDPSDSETHYNQKFKD 9 GVTRGYFDV ElectronMicroscopy N/A N/A FAB 28-JAN-13 20130128 IMMUNE SYSTEM ELECTRON CRYO - MICROSCOPY OF CHIKUNGUNYA VLP IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB CHK152 WITH NEUTRALIZING ANTIBODY FAB CHK152 ? ? MUS MUSCULUS 15 RASESVDSYGNSFMN 7 RASNLES 9 QQSNEDPFT 5 SFYIY 17 WIFPGSTNTKYNEKFKG 8 VDGYAMDY ElectronMicroscopy N/A N/A FAB 28-JAN-13 20130128 VIRUS / IMMUNE SYSTEM CONFORMATIONAL SHIFT OF A MAJOR POLIOVIRUS ANTIGEN CONFIRMED BY IMMUNO - CRYOGENIC ELECTRON MICROSCOPY: 160S POLIOVIRUS AND C3 - FAB COMPLEX MOLECULE: UNKNOWN PEPTIDE; ? ? MUS MUSCULUS 16 SSSQSLVHSNGKTYLH 7 KVSNRFS 9 SQSTHVPYT 5 NYLIQ 17 VINPGSGGTDYNANFKG 11 DFYDYDVGFDY ElectronMicroscopy N/A N/A FAB 10-APR-13 20130410 VIRUS / IMMUNE SYSTEM CONFORMATIONAL SHIFT OF A MAJOR POLIOVIRUS ANTIGEN CONFIRMED BY IMMUNO - CRYOGENIC ELECTRON MICROSCOPY: 135S POLIOVIRUS AND C3 - FAB COMPLEX MOLECULE: PROTEIN VP1; FRAGMENT: UNP RESIDUES 580 - 881; SYNONYM: P1D, VIRION PROTEIN 1; ? ? MUS MUSCULUS 16 SSSQSLVHSNGKTYLH 7 KVSNRFS 9 SQSTHVPYT 5 NYLIQ 17 VINPGSGGTDYNANFKG 11 DFYDYDVGFDY ElectronMicroscopy N/A N/A FAB 10-APR-13 20130410 IMMUNE SYSTEM STRUCTURE OF MA28 - 7 NEUTRALIZING ANTIBODY FAB FRAGMENT FROM ELECTRON CRYO - MICROSCOPY OF ENTEROVIRUS 71 COMPLEXED WITH A FAB FRAGMENT A FAB FRAGMENT ? ? MUS MUSCULUS 11 KASQDVNTALA 7 SASNRYT 9 QQHYTTPWT 5 NYDMN 17 WIFPGDGSTRYNEKFKG 11 RGFHGSYSFAY ElectronMicroscopy N/A N/A FAB 21-MAY-13 20130521 VIRUS / IMMUNE SYSTEM OBSTRUCTION OF DENGUE VIRUS MATURATION BY FAB FRAGMENTS OF THE 2H2 ANTIBODY MOLECULE: ENVELOPE PROTEIN E; FRAGMENT: UNP RESIDUES 281 - 675; KAPPA ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 9 GQSYSTPYT 5 SFGMH 17 YISSGSSTLHYADTVKG 11 WGNYPHYAMDY ElectronMicroscopy N/A N/A FAB 13-JUN-13 20130613 VIRAL PROTEIN / IMMUNE SYSTEM CRYO - EM STRUCTURE OF THE BG505 SOSIP.664 HIV - 1 ENV TRIMER WITH 3 PGV04 FABS MOLECULE: BG505 SOSIP GP41; FRAGMENT: SEE REMARK 999; ENGINEERED: YES; ? ? HOMO SAPIENS 9 TAASYGHMT 7 ATSKRAS 5 QQLEF 6 RTELIH 18 WVKTVTGAVNFGSPDFRQ 14 QKFYTGGQGWYFDL ElectronMicroscopy N/A N/A FAB 26-OCT-13 20131026 VIRUS / IMMUNE SYSTEM CRYO - EM STRUCTURE OF DENGUE VIRUS SEROTYPE 3 IN COMPLEX WITH HUMAN ANTIBODY 5J7 FAB MOLECULE: MEMBRANE PROTEIN; FRAGMENT: UNP RESIDUES 206 - 280; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISRYLN 7 GASSLQR 9 QQSQYIPYT 5 SYTFN 17 GFIPVFNTTNYAQTFQG 12 DKELLFSRAFDI ElectronMicroscopy N/A N/A FAB 26-MAR-14 20140326 VIRAL PROTEIN / IMMUNE SYSTEM MODEL OF GP120, INCLUDING VARIABLE REGIONS, IN COMPLEX WITH CD4 AND 17B MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: UNP RESIDUES 26 - 208; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ? ? HOMO SAPIENS 11 RASQDISTWLA 7 AASTLQS 8 QQANSFFT 5 DFYMY 16 LIDEDADTMYAEKFRG 8 DPWELNNV ElectronMicroscopy N/A N/A ? 22-APR-14 20140422 IMMUNE SYSTEM ELECTRON CRYO - MICROSCOPY OF HUMAN PAPILLOMAVIRUS 16 AND H16.V5 FAB FRAGMENTS ? ? ? MUS MUSCULUS 17 KSSQSLLDSRNQKNYLA 7 FASTRES 9 QQHYSTPLT 5 SYWMQ 17 AIYPGDGDTWYTQKFKG 13 PPYYYGTTYYFDY ElectronMicroscopy N/A N/A FAB 23-JUN-14 20140623 VIRUS/IMMUNE SYSTEM CRYOELECTRON MICROSCOPY OF DENGUE-FAB E104 COMPLEX AT PH 5.5 MOLECULE: GLYCOPROTEIN DIII; FRAGMENT: SEE REMARK 999; ENGINEERED: YES; ? ? UNIDENTIFIED 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A FAB 13-OCT-14 20141013 VIRUS / IMMUNE SYSTEM CRYO - EM RECONSTRUCTION OF QUASI - HPV16 COMPLEX WITH H16.14J FAB MOLECULE: L1; FRAGMENT: UNP RESIDUES 47 - 500; SYNONYM: L1 PROTEIN, MAJOR CAPSID PROTEIN L1; ? ? MUS MUSCULUS 11 KASDHINNWLA 7 GATSLET 9 QQYWSTPLT 5 SYWMN 17 QIYPGDGATNYNGKFKG 13 PYRYDGGVYAMDY ElectronMicroscopy N/A N/A FAB 19-NOV-14 20141119 VIRUS / IMMUNE SYSTEM CRYO - EM RECONSTRUCTION OF QUASI - HPV16 COMPLEX WITH H263.A2 FAB MOLECULE: L1; FRAGMENT: UNP RESIDUES 47 - 500; SYNONYM: L1 PROTEIN, MAJOR CAPSID PROTEIN L1 ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAETLAE 9 QHHYVSPLT 5 SYWMQ 17 AIYPGDGATRYTQKFKG 13 PSYYDYDVTWFAY ElectronMicroscopy N/A N/A FAB 19-NOV-14 20141119 VIRUS / IMMUNE SYSTEM CRYO - EM RECONSTRUCTION OF QUASI - HPV16 COMPLEX WITH H16.1A FAB MOLECULE: L1; FRAGMENT: UNP RESIDUES 47 - 500; SYNONYM: L1 PROTEIN, MAJOR CAPSID PROTEIN L1; ? ? MUS MUSCULUS 17 KSSQSLFDSRNQKNYLA 7 FASTRES 9 QQHYSTPYT 5 SYWMQ 17 AIYPGDGYTRYTQKFKG 12 TYAGYYVGYFDY ElectronMicroscopy N/A N/A FAB 20-NOV-14 20141120 IMMUNE SYSTEM FITTING OF FAB INTO THE CRYOEM DENSITY MAP OF EV71 PROCAPSID IN COMPLEX WITH FAB22A12 WITH FAB22A12 ? ? MUS MUSCULUS 11 KASQDVNTALA 7 SASNRYT 9 QQHYTTPWT 5 NYDMN 17 WIFPGDGSTRYNEKFKG 11 RGFHGSYSFAY ElectronMicroscopy N/A N/A FAB 02-DEC-14 20141202 HYDROLASE / IMMUNE SYSTEM DOMAIN ORGANIZATION AND CONFORMATIONAL PLASTICITY OF THE G PROTEIN EFFECTOR, PDE6 MOLECULE: GAFA DOMAIN OF CONE PHOSPHODIESTERASE 6C; FRAGMENT: SEE REMARK 999; SYNONYM: CONE CGMP - SPECIFIC 3',5' - CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA'; KAPPA IGG1 MUS MUSCULUS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 DYYIH 17 WIDPEIGDTEYVPKFQG 11 GHDYDRGRFPY ElectronMicroscopy N/A N/A FAB 26-MAY-15 20150526 VIRUS / IMMUNE SYSTEM THE CRYOEM MAP OF EV71 MATURE VIRON IN COMPLEX WITH THE FAB FRAGMENT OF ANTIBODY D5 MOLECULE: CAPSID PROTEIN VP1; FRAGMENT: UNP RESIDUES 207 - 223; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 YQGSHVPYT 5 DTYIH 17 KIDPANGNTKYDPKFQD 9 SNYWFDFDY ElectronMicroscopy N/A N/A FAB 24-JUN-15 20150624 VIRUS / IMMUNE SYSTEM THE U4 ANTIBODY EPITOPE ON HUMAN PAPILLOMAVIRUS 16 IDENTIFIED BY CRYO - EM MOLECULE: MAJOR CAPSID PROTEIN L1; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLYSNTQKNYLA 7 WASTRES 9 QQYYSYPLT 5 SYAMS 16 SISSGGNTHYPDSVKG 14 GLYYGYDEGSDFDY ElectronMicroscopy N/A N/A FAB 11-AUG-15 20150811 VIRUS / IMMUNE SYSTEM COMPLEX OF POLIOVIRUS WITH VHH PVSP29F ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 5; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 0 0 0 0 0 ElectronMicroscopy N/A N/A Nanobody 26-AUG-15 20150826 VIRUS / IMMUNE SYSTEM COMPLEX OF POLIOVIRUS WITH VHH PVSP6A ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 5; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 0 0 0 0 0 ElectronMicroscopy N/A N/A Nanobody 26-AUG-15 20150826 VIRUS / IMMUNE SYSTEM COMPLEX OF POLIOVIRUS WITH VHH PVSS8A ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 5; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 0 0 0 0 0 ElectronMicroscopy N/A N/A Nanobody 26-AUG-15 20150826 VIRUS / IMMUNE SYSTEM COMPLEX OF POLIOVIRUS WITH VHH PVSP19B ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 5; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 0 0 0 0 0 ElectronMicroscopy N/A N/A nanobody 26-AUG-15 20150826 VIRUS / IMMUNE SYSTEM COMPLEX OF POLIOVIRUS WITH VHH PVSS21E ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: HUMAN POLIOVIRUS 1 MAHONEY; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 5; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 0 0 0 0 0 ElectronMicroscopy N/A N/A Nanobody 26-AUG-15 20150826 HYDROLASE / IMMUNE SYSTEM DOMAIN ORGANIZATION AND CONFORMATIONAL PLASTICITY OF THE G PROTEIN EFFECTOR, PDE6 MOLECULE: PHOSPHODIESTERASE 5 / 6 CHIMERA CATALYTIC DOMAIN; FRAGMENT: SEE REMARK 999; SYNONYM: CGMP - SPECIFIC 3',5' - CYCLIC PHOSPHODIESTERASE, CONE CGMP - SPECIFIC 3',5' - CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA' CHIMERA; KAPPA IGG1 MUS MUSCULUS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 DYYIH 16 WIDEIGDTEYVPKFQG 8 GHDYDRPY ElectronMicroscopy N/A N/A FAB 17-SEP-15 20150917 VIRUS / IMMUNE SYSTEM CANINE PARVOVIRUS COMPLEXED WITH FAB E MOLECULE: CAPSID PROTEIN 2; SYNONYM: VP2; ? ? RATTUS NORVEGICUS 11 KASQNVDSNVD 7 KASNRNT 9 MQSTSYPLT 5 SYHVH 16 VMWNDGDTSYNLALNS 14 PELPGLTYGVWFPY ElectronMicroscopy N/A N/A FAB 21-MAR-16 20160321 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A 3B3 VARIANT, A BROADLY NEUTRALIZING HIV - 1 SCFV ANTIBODY ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.50A 20.10% scFv 15-SEP-09 20090915 VIRAL PROTEIN STRUCTURE OF HIV - 1 GP120 WITH GP41 - INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY MOLECULE: HIV - 1 GP120 ENVELOPE GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDISTWLA 7 AASTLQS 8 QQANSFFT 5 DFYMY 17 LIDPEDADTMYAEKFRG 10 DPWELNAFNV crystal 2.61A 20.10% FAB 18-SEP-09 20090918 VIRAL PROTEIN STRUCTURE OF HIV - 1 GP120 WITH GP41 - INTERACTIVE REGION: LAYERED ARCHITECTURE AND BASIS OF CONFORMATIONAL MOBILITY MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDISTWLA 7 AASTLQS 8 QQANSFFT 5 DFYMY 17 LIDPEDADTMYAEKFRG 10 DPWELNAFNV crystal 3.51A 25.80% FAB 18-SEP-09 20090918 LUMINESCENT PROTEIN / IMMUNE SYSTEM GREEN FLUORESCENT PROTEIN BOUND TO ENHANCER NANOBODY MOLECULE: GREEN FLUORESCENT PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 RYSMR 17 GMSSAGDRSSYEDSVKG 6 NVGFEY crystal 2.15A 21.50% HC-dimer 28-SEP-09 20090928 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HGFA IN COMPLEX WITH THE ALLOSTERIC INHIBITORY ANTIBODY FAB40 MOLECULE: HEPATOCYTE GROWTH FACTOR ACTIVATOR SHORT CHAIN; SYNONYM: HGF ACTIVATOR, HGFA; EC: 3.4.21. -; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSNRAPAT 5 GTYIH 17 GIYPAGGATYYADSVKG 9 WWAWPAFDY crystal 2.35A 23.90% FAB 30-SEP-09 20090930 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A LLAMA ANTIBODY COMPLEXED WITH THE C. BOTULINUM NEUROTOXIN SEROTYPE A CATALYTIC DOMAIN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; GENE: LLAMA VHH IMMUNOGLOBULIN; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21 (DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET20B; MOL_ID: 2; ORGANISM_SCIENTIFIC: CLOSTRIDIUM BOTULINUM A STR. HALL; ORGANISM_TAXID: 441771; GENE: BOTA, CBO0806, CLC_0862, NEUROTOXIN CATALYTIC DOMAIN; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21 (DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET15B; MOL_ID: 3; ORGANISM_SCIENTIFIC: CLOSTRIDIUM BOTULINUM A STR. HALL; ORGANISM_TAXID: 441771; GENE: BOTA, CBO0806, CLC_0862, NEUROTOXIN CATALYTIC DOMAIN; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21 (DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET15B 0 0 0 0 0 0 crystal 2.60A 21.80% VHH 04-OCT-09 20091004 OXIDOREDUCTASE DISRUPTION OF PROTEIN DYNAMICS BY AN ALLOSTERIC EFFECTOR ANTIBODY MOLECULE: DIHYDROFOLATE REDUCTASE; EC: 1.5.1.3; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYWMY 17 MINPGGIITKYAESVKG 9 DWATGLAKK crystal 1.95A 19.80% HC-dimer 12-OCT-09 20091012 IMMUNE SYSTEM, RNA BINDING PROTEIN STRUCTURE OF ESSENTIAL PROTEIN FROM TRYPANOSOMA BRUCEI MOLECULE: MP18 RNA EDITING COMPLEX PROTEIN; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NNAMG 17 AISWTGGLLFYADSVNG 13 RPQGDYVTAHYDY crystal 2.10A 20.50% HC-dimer 13-OCT-09 20091013 IMMUNE SYSTEM, RNA BINDING PROTEIN STRUCTURE OF ESSENTIAL PROTEIN FROM TRYPANOSOMA BRUCEI MOLECULE: MP18 RNA EDITING COMPLEX PROTEIN; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYGMG 19 VAAISRSGGLTQYAESLKG 15 DLYGLGSHMENEYDS crystal 2.40A 22.60% HC-dimer 13-OCT-09 20091013 IMMUNE SYSTEM, RNA BINDING PROTEIN STRUCTURE OF THE CENTRAL INTERACTION PROTEIN FROM THE TRYPANOSOMA BRUCEI EDITOSOME IN COMPLEX WITH SINGLE DOMAIN ANTIBODIES MOLECULE: MP18 RNA EDITING COMPLEX PROTEIN; FRAGMENT: KREPA6; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SEAWG 16 AINNEGRTNYVDSVKG 13 NLQTGTLSGARLY crystal 3.40A 26.90% HC-dimer 13-OCT-09 20091013 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - STEROID FAB 5F2 IN COMPLEX WITH TESTOSTERONE WITH TESTOSTERONE ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 GVTNRPS 11 SSYTSTRTPYV 5 SYAMS 17 AISGSGGSTYYADSVKG 13 DPGLWDYYYGMDV crystal 1.50A 18.10% FAB 23-OCT-09 20091023 PROTEIN BINDING CRYSTAL STRUCTURE OF MURINE IG - BETA (CD79B) HOMODIMER ? ? ? MUS MUSCULUS 17 SSMVKFHCYTNHSGALT 0 8 KQKCNVTD 0 N/A 0 N/A 0 N/A crystal 3.11A 20.60% LC-dimer 30-OCT-09 20091030 PROTEIN BINDING CRYSTAL STRUCTURE OF MURINE IG - BETA (CD79B) IN THE MONOMERIC FORM ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: CD79B, IGB; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 17 SSMVKFHCYTNHSGALT 0 6 KQKCDS 0 N/A 0 N/A 0 N/A crystal 1.70A 18.80% LC-dimer 30-OCT-09 20091030 IMMUNE SYSTEM STRUCTURE OF RAT NOGO RECEPTOR BOUND TO 1D9 ANTAGONIST ANTIBODY MOLECULE: RETICULON - 4 RECEPTOR; FRAGMENT: UNP RESIDUES 27 - 312; SYNONYM: NOGO RECEPTOR, NGR, NOGO - 66 RECEPTOR; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRNRKNYLA 7 WASTRES 8 MQSYNLFT 5 SYGVH 16 VIWSGGNTHYNSALMS 8 YEGAWFAY crystal 3.10A 25.60% FAB 02-NOV-09 20091102 SIGNALING PROTEIN CRYSTAL STRUCTURE OF A METHYLATED BETA2 ADRENERGIC RECEPTOR - FAB COMPLEX MOLECULE: BETA - 2 ADRENERGIC RECEPTOR; SYNONYM: BETA - 2 ADRENORECEPTOR, BETA - 2 ADRENOCEPTOR; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDINSYLS 7 RANRLVD 9 LQYDEFPYT 5 DYYIN 17 EIYPGSGNIDYNERFKD 4 GFGY crystal 3.40A 24.20% FAB 02-NOV-09 20091102 TRANSFERASE / DNA CRYSTAL STRUCTURE OF AZT - RESISTANT HIV - 1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST - TRANSLOCATION AZTMP - TERMINATED DNA (COMPLEX P) MOLECULE: P51 RT; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 2.90A 26.00% ? 07-NOV-09 20091107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IGF - II ANTIBODY COMPLEX MOLECULE: INSULIN - LIKE GROWTH FACTOR II; SYNONYM: IGF - II, SOMATOMEDIN - A; ENGINEERED: YES; ? ? HOMO SAPIENS 11 CRASQSISNYL 7 YTASTLQ 10 CQQSYNSPWT 5 NYIMW 17 VISSSGGMTRYADSVKG 13 DNGDYVGEKGFDI crystal 2.20A 20.20% FAB 17-NOV-09 20091117 OXIDOREDUCTASE CRYSTAL STRUCTURE OF THE HEME DOMAIN OF FLAVOCYTOCHROME B2 IN COMPLEX WITH FAB B2B4 MOLECULE: CYTOCHROME B2, MITOCHONDRIAL; SYNONYM: L - LACTATE DEHYDROGENASE [CYTOCHROME] , L - LACTATE FERRICYTOCHROME C OXIDOREDUCTASE, L - LCR; EC: 1.1.2.3; ENGINEERED: YES ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNKRAP 9 ALWDSNHLV 5 SGYWN 16 YISYGGSTYYNPSLES 9 LFGSYYFDY crystal 2.70A 21.80% FAB 20-NOV-09 20091120 IMMUNE SYSTEM CRYSTAL STRUCTURE OF LI33 IGG1 FAB ? ? IGG1 HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQYDKWPLT 5 IYPMF 17 WIGPSGGITKYADSVKG 10 EGHNDWYFDL crystal 3.20A 19.80% FAB 06-DEC-09 20091206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF LI33 IGG2 DI - FAB ? ? IGG2 HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQYDKWPLT 5 IYPMF 17 WIGPSGGITKYADSVKG 10 EGHNDWYFDL crystal 2.62A 26.70% FAB 06-DEC-09 20091206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY MN423 FAB FRAGMENT WITH FREE COMBINING SITE, CRYSTALLIZED IN THE PRESENCE OF ZINC ? ? ? MUS MUSCULUS 11 RASKSIRKFLA 7 SGSTLQS 9 QQHNDYPLT 5 DYYMS 19 LIRNKAKGYTTEYSASVKG 11 DNGAARATFAY crystal 2.00A 16.20% FAB 14-DEC-09 20091214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL - 13 AND C836 FAB MOLECULE: INTERLEUKIN - 13; FRAGMENT: UNP RESIDUES 35 - 146; SYNONYM: IL - 13; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASKSISKYLA 7 SGSTLQS 9 QQHNEYPYT 7 TYGMGVG 16 HIWWDDVKRYNPALKS 11 MGSDYDVWFDY crystal 2.00A 20.80% FAB 22-DEC-09 20091222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL - 13 AND H2L6 FAB MOLECULE: INTERLEUKIN - 13; FRAGMENT: UNP RESIDUES 35 - 146; SYNONYM: IL - 13; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASKSISKYLA 7 SGSTLQS 9 QQHNEYPYT 7 TYGMGVG 16 HIWWDDVKRYNPALKS 11 MGSDYDVWFDY crystal 1.90A 20.90% FAB 22-DEC-09 20091222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 13 ANTIBODY C836 MOLECULE: C836 LIGHT CHAIN; FRAGMENT: CHIMERIC MOLECULE OF MOUSE VARIABLE DOMAIN AND HUMAN CONSTANT DOMAIN; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASKSISKYLA 7 SGSTLQS 9 QQHNEYPYT 7 TYGMGVG 16 HIWWDDVKRYNPALKS 11 MGSDYDVWFDY crystal 2.50A 20.40% ? 28-DEC-09 20091228 IMMUNE SYSTEM STRUCTURE OF IL - 13 ANTIBODY H2L6, A HUMANIZED VARIANT OF C836 MOLECULE: H2L6 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASKSISKYLA 7 SGSTLQS 9 QQHNEYPYT 7 TYGMGVG 16 HIWWDDVKRYNPALKS 11 MGSDYDVWFDY crystal 2.60A 20.70% ? 28-DEC-09 20091228 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN NOTCH1 NEGATIVE REGULATORY REGION (NRR) BOUND TO THE FAB FRAGMENT OF AN ANTAGONIST ANTIBODY MOLECULE: NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; FRAGMENT: NEGATIVE REGULATORY REGION (NRR1); SYNONYM: NOTCH 1, HN1, TRANSLOCATION - ASSOCIATED NOTCH PROTEIN TAN - 1, NOTCH 1 EXTRACELLULAR TRUNCATION, NOTCH 1 INTRACELLULAR DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQFYTTPST 5 SYWIH 17 RINPPNRSNQYADSVKG 10 GSGFRWVMDY crystal 2.19A 22.70% FAB 04-JAN-10 20100104 IMMUNE SYSTEM STRUCTURE OF JMJD6 AND FAB FRAGMENTS MOLECULE: BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL - HYDROXYLASE JMJD6; SYNONYM: HISTONE ARGININE DEMETHYLASE JMJD6, PEPTIDE - LYSINE 5 - DIOXYGENASE JMJD6, LYSYL - HYDROXYLASE JMJD6, JMJC DOMAIN - CONTAINING PROTEIN 6, JUMONJI DOMAIN - CONTAINING PROTEIN 6, PHOSPHATIDYLSERINE RECEPTOR, PROTEIN PTDSR; EC: 1.14.11. -; ENGINEERED: YES; ? ? CRICETULUS MIGRATORIUS 17 RSSQSLYYSGIKKNLLA 7 YASTLFT 9 QQGISNPYT 5 SYHWS 16 YIYNSGGTDYNPSLKS 10 RDYGTYYFDY crystal 2.70A 23.30% FAB 12-JAN-10 20100112 IMMUNE SYSTEM STRUCTURE OF JMJD6 COMPLEXD WITH ALPHA - KETOGLUTARATE AND FAB FRAGMENT. MOLECULE: BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL - HYDROXYLASE JMJD6; SYNONYM: HISTONE ARGININE DEMETHYLASE JMJD6, PEPTIDE - LYSINE 5 - DIOXYGENASE JMJD6, LYSYL - HYDROXYLASE JMJD6, JMJC DOMAIN - CONTAINING PROTEIN 6, JUMONJI DOMAIN - CONTAINING PROTEIN 6, PHOSPHATIDYLSERINE RECEPTOR, PROTEIN PTDSR; EC: 1.14.11. -; ENGINEERED: YES; ? ? CRICETULUS MIGRATORIUS 17 RSSQSLYYSGIKKNLLA 7 YASTLFT 9 QQGISNPYT 5 SYHWS 16 YIYNSGGTDYNPSLKS 10 RDYGTYYFDY crystal 2.70A 25.00% FAB 12-JAN-10 20100112 IMMUNE SYSTEM HIV - 1 ANTIBODY 2F5 IN COMPLEX WITH EPITOPE SCAFFOLD ES2 MOLECULE: RNA POLYMERASE SIGMA FACTOR; FRAGMENT: UNP RESIDUES 93 - 271; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.50A 20.60% ? 15-JAN-10 20100115 IMMUNE SYSTEM 2F5 EPITOPE SCAFFOLD ELICITED ANTI - HIV - 1 MONOCLONAL ANTIBODY 11F10 IN COMPLEX WITH HIV - 1 GP41 MOLECULE: ENVELOPE GLYCOPROTEIN GP41; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLAS 9 WQGTHFPWT 6 SDYAWS 16 YINYSGYTSYNPSLKS 7 GNYLPAY crystal 1.97A 16.60% ? 15-JAN-10 20100115 IMMUNE SYSTEM 2F5 EPITOPE SCAFFOLD ELICITED ANTI - HIV - 1 MONOCLONAL ANTIBODY 6A7 IN COMPLEX WITH HIV - 1 GP41 MOLECULE: ENVELOPE GLYCOPROTEIN GP41; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLAS 9 WQGTHFPWT 6 TDYAWN 16 YISYSGFTSYNPSLKS 7 GNYLPAY crystal 1.99A 18.00% ? 15-JAN-10 20100115 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV EPITOPE - SCAFFOLD 4E10_1VI7A_S0_002_N 4E10 FV COMPLEX MOLECULE: 4E10_1VI7A_S0_002_N (T88); ENGINEERED: YES; OTHER_DETAILS: THE AUTHOR STATES THAT THE EPITOPE - SCAFFOLD IS BASED ON THE RIBOSOME RECYCLING FACTOR FROM VIBRIO PARAHAEMOLYTICUS (PDB ID 1IS1) .; ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 14 EGTTLGKPIGAFAH crystal 2.65A 22.40% FV 21-JAN-10 20100121 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV EPITOPE - SCAFFOLD 4E10_D0_1ISEA_004_N 4E10 FV COMPLEX MOLECULE: 4E10_D0_1ISEA_004_N (T93); ENGINEERED: YES; OTHER_DETAILS: THE EPITOPE - SCAFFOLD IS BASED ON A MUTANT OF RIBOSOME RECYCLING FACTOR FROM ESCHERICHIA COLI (PDB ID 1ISE) ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 15 EGTTGLGKPIGAFAH crystal 2.70A 24.70% FV 22-JAN-10 20100122 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BLA G 2 COMPLEXED WITH FAB 4C3 MOLECULE: ASPARTIC PROTEASE BLA G 2; SYNONYM: ALLERGEN BLA G II; EC: 3.4.23. -; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDINNYLS 7 RADRLVD 9 LQYDELPYT 5 SFAMS 17 TINSNGASTYYPDTVKG 10 DPAGRAWFAY crystal 1.80A 17.80% FAB 25-JAN-10 20100125 IMMUNE SYSTEM STRUCTURE OF HUMAN ANTI HIV 21C FAB ? ? ? HOMO SAPIENS 13 SGSSSNIGKNYVS 7 DDTQRPS 12 GTWDSSLSTGQL 5 GLSIH 17 GFGPEENEIIYAQKFQG 16 GGNYYNLWTGYYPLAY crystal 2.20A 19.40% FAB 30-JAN-10 20100130 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FIBRIL - SPECIFIC B10 ANTIBODY FRAGMENT ? ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 HRYHR 19 VAVISQSGMRTYYADSVKG 15 GTRKNVWTRQHPFDY crystal 1.80A 19.90% HC-dimer 02-FEB-10 20100202 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CLADE C GP120 IN COMPLEX WITH SCD4 AND 21C FAB MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGKNYVS 7 DDTQRPS 12 GTWDSSLSTGQL 5 GLSIH 17 GFGPEENEIIYAQKFQG 16 GGNYYNLWTGYYPLAY crystal 3.40A 23.40% FAB 08-FEB-10 20100208 IMMUNE SYSTEM STRUCTURE OF ANTI - HUNTINGTIN VL DOMAIN MOLECULE: ANTI - HUNTINGTIN VL DOMAIN; FRAGMENT: ANTI - HUNTINGTIN VL DOMAIN; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 17 TISVSGSNSNIGSNTVN 7 DDDLLAP 12 AATWDDSLNGWV 0 N/A 0 N/A 0 N/A crystal 2.05A 17.20% LC-dimer 11-FEB-10 20100211 IMMUNE SYSTEM STRUCTURE OF ANTI - HUNTINGTIN VL DOMAIN IN COMPLEX WITH HUNTINGTIN PEPTIDE MOLECULE: HUNTINGTIN; FRAGMENT: HUNTINGTIN PEPTIDE; SYNONYM: HUNTINGTON DISEASE PROTEIN, HD PROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 17 TISVSGSNSNIGSNTVN 7 DDDLLAP 12 AATWDDSLNGWV 0 N/A 0 N/A 0 N/A crystal 2.60A 21.90% LC-dimer 11-FEB-10 20100211 IMMUNE SYSTEM STRUCTURE OF PG16, AN ANTIBODY WITH BROAD AND POTENT NEUTRALIZATION OF HIV - 1 ? ? ? HOMO SAPIENS 14 NGTSSDVGGFDSVS 7 DVSHRPS 10 SSLTDRSHRI 5 KYGMH 16 LISDDGMRKYHSDSMW 19 REAGGPINDGYYNYHYMDV crystal 2.37A 21.30% FAB 11-FEB-10 20100211 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - TETRAHYDROCANNABINOL FAB FRAGMENT IN COMPLEX WITH THC WITH THC ? ? MUS MUSCULUS 12 SASSSISSNYLH 7 RTSNLAS 9 QQGSSIPLT 5 NYVMV 16 SISRGGSTYYPDSVKG 9 GTTIVAGDV crystal 2.00A 21.60% FAB 12-FEB-10 20100212 IMMUNE SYSTEM ANTI - TETRAHYDROCANNABINOL FAB FRAGMENT, FREE FORM ? ? ? MUS MUSCULUS 12 SASSSISSNYLH 7 RTSNLAS 9 QQGSSIPLT 5 NYVMV 16 SISRGGSTYYPDSVKG 9 GTTIVAGDV crystal 1.90A 21.50% FAB 12-FEB-10 20100212 IMMUNOGLOBULIN LEN Q38E MUTANT: A DOMAIN FLIP FROM A SINGLE AMINO ACID SUBSTITUTION ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: DH-5ALPHA 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 2.00A 17.60% LC-dimer 12-MAY-98 19980512 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 2D1 IN COMPLEX WITH THE 1918 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ, HA2 SUBUNIT; FRAGMENT: ECTODOMAIN HA2, RESIDUES 345 - 520; SYNONYM: HEMAGGLUTININ HA1 CHAIN, HEMAGGLUTININ HA2 CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNTVS 7 GNNERPS 12 AAWDDSLNGFWV 7 TSGMSVS 19 LIDWDDDTYYITYSSSLKT 14 TLRVSGDYVRDFDL crystal 2.80A 23.20% FAB 01-MAR-10 20100301 IMMUNE SYSTEM HUMAN IGA1 FAB FRAGMENT ? ? IGA HOMO SAPIENS 16 RSSQSLLRRDGHNDLE 7 LGSTRAS 9 MQNKQTPLT 5 GSNVH 19 RIKRNAESDATAYAASMRG 8 RGDVYNRQ crystal 1.55A 15.40% FAB 18-MAR-10 20100318 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GP41 DERIVED PROTEIN COMPLEXED WITH FAB 8066 MOLECULE: TRANSMEMBRANE GLYCOPROTEIN; SYNONYM: GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNIPYEYAS 7 GDNNRPS 11 ASWDSMTVDGV 5 SYAFS 17 SIIPIFGTTNYAQKFQG 12 YFDTYNNYGFAN crystal 2.05A 19.40% FAB 23-MAR-10 20100323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GP41 - DERIVED PROTEIN COMPLEXED WITH FAB 8062 MOLECULE: TRANSMEMBRANE GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNIPYEYAS 7 GDNNRPS 11 ASWDSMTVDGV 5 SYAFS 17 SIIPLFGFVVYAQKFQG 12 YFDTYNNYGFAN crystal 2.50A 20.20% FAB 23-MAR-10 20100323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CHIMERIC ANTIBODY X836 MOLECULE: X836 LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSLLYNNNQKNYLA 7 WASTRES 9 QQYYSYPFT 7 TYGMGVG 16 HIWWDDVKRYNPALKS 11 MGSDYDVWFDY crystal 1.60A 21.10% ? 26-MAR-10 20100326 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF A LIGHT CHAIN DIMER CRYSTALLIZED IN WATER. CONFORMATIONAL FLEXIBILITY OF A MOLECULE IN TWO CRYSTAL FORMS ? LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.00A 20.80% LC-dimer 09-MAY-89 19890509 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - BETA - AMYLOID ANTIBODY C705 MOLECULE: C705 MONOCLONAL LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLE 7 KVSNRFS 9 FQGSRVPLT 7 TSGMGVS 16 HIYWDDDKRYNPSLKS 13 SSGSIVIATGFAY crystal 2.30A 20.40% ? 29-MAR-10 20100329 IMMUNE SYSTEM ANTI - BETA - AMYLOID ANTIBODY C706 FAB IN SPACE GROUP P21 MOLECULE: C706 MONOCLONAL LIGHT CHAIN; FRAGMENT: CHIMERIC MOLECULE OF MOUSE VARIABLE DOMAIN AND HUMAN CONSTANT DOMAIN; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 10 SASSSVSYMH 7 DSSRLAS 8 QNWRSSPT 5 TSWIE 17 EVLPGSGKSNHNANFKG 10 EGSNNNALAY crystal 1.70A 20.50% FAB 29-MAR-10 20100329 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HL4E10 FAB, A HAMSTER AB STIMULATORY FOR GAMMADELTA T CELLS ? ? ? CRICETULUS MIGRATORIUS 11 SGDKLSDVYVH 7 EDNRRPS 11 QSWDGTNSAWV 5 DYGVH 16 IIGHAGGTDYNSNLKS 8 HFYTYFDV crystal 2.94A 23.00% FAB 12-APR-10 20100412 IMMUNE SYSTEM CRYSTAL STRUCTURE OF JAML IN COMPLEX WITH THE STIMULATORY ANTIBODY HL4E10 MOLECULE: JUNCTIONAL ADHESION MOLECULE - LIKE; FRAGMENT: EXTRACELLULAR DOMAIN (UNP RESIDUES 21 - 280); SYNONYM: DENDRITIC CELL - SPECIFIC PROTEIN CREA7, MCREA7; ENGINEERED: YES; MUTATION: YES; ? ? CRICETULUS MIGRATORIUS 11 SGDKLSDVYVH 7 EDNRRPS 11 QSWDGTNSAWV 5 DYGVH 16 IIGHAGGTDYNSNLKS 8 HFYTYFDV crystal 2.95A 22.50% FAB 12-APR-10 20100412 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 2557 IN COMPLEX WITH A NY5 V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 11 SGDKLDDKYVS 7 QDFKRPS 15 QAWDASTGVSGGGTK 5 DSWIG 17 IIYPDDSDAHYSPSFEG 15 LYLFEGAQSSNAFDL crystal 1.80A 18.10% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 MAB 2557 FAB IN COMPLEX WITH A HIV - 1 GP120 V3 MIMOTOPE MOLECULE: RATIONALLY DESIGNED V3 MIMOTOPE; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDKLDDKYVS 7 QDFKRPS 15 QAWDASTGVSGGGTK 5 DSWIG 17 IIYPDDSDAHYSPSFEG 15 LYLFEGAQSSNAFDL crystal 2.50A 21.60% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 2557 IN COMPLEX WITH A UG1033 V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 11 SGDKLDDKYVS 7 QDFKRPS 13 QAWDASGTKLTVL 5 DSWIG 17 IIYPDDSDAHYSPSFEG 15 LYLFEGAQSSNAFDL crystal 2.49A 20.60% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 2557 IN COMPLEX WITH A ZAM18 V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 11 SGDKLDDKYVS 7 QDFKRPS 15 QAWDASTGVSGGGTK 5 DSWIG 17 IIYPDDSDAHYSPSFEG 15 LYLFEGAQSSNAFDL crystal 2.77A 20.20% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 2557 IN COMPLEX WITH AN NOF V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 11 SGDKLDDKYVS 7 QDFKRPS 15 QAWDASTGVSGGGTK 5 DSWIG 17 IIYPDDSDAHYSPSFEG 15 LYLFEGAQSSNAFDL crystal 2.48A 23.90% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 1006 - 15D IN COMPLEX WITH AN MN V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 13 SGNSSNIENNYVY 7 RDDQRPS 13 ASWDDSRGGPDYV 5 DHWIA 17 MIYPGDSDTRYSPSLQG 17 LHYSDRSGSYFNDVFHM crystal 2.70A 21.80% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 3074 IN COMPLEX WITH AN MN V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 13 SGSSSNIGNNMVS 7 ENSKRPS 10 ATWDGSLRTV 5 GFHWS 16 YIYYSGSTSYNPSLKS 19 DFGEYHYDGRGFQCEGFDL crystal 1.90A 19.20% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 3074 IN COMPLEX WITH A UR29 V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 13 SGSSSNIGNNMVS 7 ENSKRPS 10 ATWDGSLRTV 5 GFHWS 16 YIYYSGSTSYNPSLKS 19 DFGEYHYDGRGFQCEGFDL crystal 1.70A 18.20% FAB 18-APR-10 20100418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 3074 IN COMPLEX WITH A VI191 V3 PEPTIDE MOLECULE: HIV - 1 GP120 THIRD VARIABLE REGION (V3) CROWN; ? ? HOMO SAPIENS 13 SGSSSNIGNNMVS 7 ENSKRPS 10 ATWDGSLRTV 5 GFHWS 16 YIYYSGSTSYNPSLKS 19 DFGEYHYDGRGFQCEGFDL crystal 2.99A 19.80% FAB 18-APR-10 20100418 IMMUNE SYSTEM STRUCTURE AND FUNCTIONAL DISSECTION OF PG16, AN ANTIBODY WITH BROAD AND POTENT NEUTRALIZATION OF HIV - 1 ? ? ? HOMO SAPIENS 14 NGTSSDVGGFDSVS 7 DVSHRPS 10 SSLTDRSHRI 5 KYGMH 16 LISDDGMRKYHSDSMW 15 REAGGPYYNYHYMDV crystal 3.97A 25.90% FAB 19-APR-10 20100419 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NON - NEUTRALIZING HIV ANTIBODY 13H11 FAB FRAGMENT ? ? ? MUS MUSCULUS,HOMO SAPIENS 17 RCKSSQSLLNSRNERNY 7 VYFASIR 11 FCLQHYNTPWT 6 TDYSVH 17 GWINTETGEPTYADDFK 5 LGWLH crystal 2.40A 18.30% FAB 22-APR-10 20100422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NON - NEUTRALIZING HIV ANTIBODY 13H11 FAB FRAGMENT WITH A GP41 MPER - DERIVED PEPTIDE IN A HELICAL CONFORMATION MOLECULE: GP41; ENGINEERED: YES; ? ? MUS MUSCULUS,HOMO SAPIENS 17 CKSSQSLLNSRNERNYL 7 YFASIRE 10 CLQHYNTPWT 5 DYSVH 17 WINTETGEPTYADDFKG 4 GWLH crystal 2.20A 18.70% FAB 22-APR-10 20100422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NON - NEUTRALIZING HIV ANTIBODY 13H11 FAB FRAGMENT WITH A GP41 MPER - DERIVED PEPTIDE BEARING ALA SUBSTITUTIONS IN A HELICAL CONFORMATION MOLECULE: GP41 MPER - DERIVED PEPTIDE; ENGINEERED: YES; ? ? MUS MUSCULUS,HOMO SAPIENS 17 CKSSQSLLNSRNERNYL 7 YFASIRE 10 CLQHYNTPWT 5 DYSVH 17 WINTETGEPTYADDFKG 4 GWLH crystal 1.80A 18.00% FAB 22-APR-10 20100422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NON - NEUTRALIZING HIV ANTIBODY 13H11 FAB FRAGMENT ? ? ? MUS MUSCULUS,HOMO SAPIENS 17 CKSSQSLLNSRNERNYL 7 YFASIRE 10 CLQHYNTPWT 6 TDYSVH 17 GWINTETGEPTYADDFK 5 LGWLH crystal 1.80A 18.90% FAB 22-APR-10 20100422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEUTRALIZING HIV ANTIBODY 2F5 FAB FRAGMENT (RECOMBINANTLY PRODUCED FAB) WITH 17 AA GP41 MPER - DERIVED PEPTIDE MOLECULE: GP41 MPER - DERIVED PEPTIDE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.30A 18.60% FAB 22-APR-10 20100422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEUTRALIZING HIV ANTIBODY 2F5 FAB FRAGMENT (RECOMBINANTLY PRODUCED FAB) WITH 11 AA GP41 MPER - DERIVED PEPTIDE MOLECULE: GP41 MPER - DERIVED PEPTIDE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.60A 19.50% FAB 22-APR-10 20100422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEUTRALIZING HIV ANTIBODY 2F5 FAB FRAGMENT (RECOMBINANTLY PRODUCED IGG) WITH 11 AA GP41 MPER - DERIVED PEPTIDE MOLECULE: GP41 MPER - DERIVED PEPTIDE; ENGINEERED: YES; ? IGG HOMO SAPIENS 11 RASQGVTSALA 7 DASSLES 9 QQLHFYPHT 7 DFGVGVG 16 IIYSDDDKRYSPSLNT 22 RRGPTTLFGVPIARGPVNAMDV crystal 2.20A 18.60% FAB 22-APR-10 20100422 NEUROPEPTIDE, IMMUNE SYSTEM AMYLOID BETA (18 - 41) PEPTIDE FUSION WITH NEW ANTIGEN RECEPTOR VARIABLE DOMAIN FROM SHARKS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ORECTOLOBUS MACULATUS, HOMO SAPIENS, ORECTOLOBUS MACULATUS,; ORGANISM_COMMON: SPOTTED WOBBEGONG, HUMAN, SPOTTED WOBBEGONG; ORGANISM_TAXID: 168098, 9606, 168098; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PGC 0 0 0 0 0 0 crystal 2.05A 19.30% NAR 23-APR-10 20100423 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PG16, A BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 14 NGTSSDVGGFDSVS 7 DVSHRPS 10 SSLTDRSHRI 5 KYGMH 16 LISDDGMRKYHSDSMW 26 REAGGPIWHDDVKYDFNDGYYNYHYM crystal 2.49A 20.90% FAB 03-MAY-10 20100503 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PG9 LIGHT CHAIN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK 293S GNTI -/- 14 NGTSNDVGGYESVS 7 DVSKRPS 10 KSLTSTRRRV 0 N/A 0 N/A 0 N/A crystal 3.00A 24.80% LC-dimer 03-MAY-10 20100503 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - SHH 5E1 CHIMERA ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQSVSNDLT 7 YASNRYT 9 QQDYGSPPT 5 DEALH 17 VIRPYSGETNYNQKFKD 10 DWERGDFFDY crystal 1.90A 18.30% FAB 07-MAY-10 20100507 SIGNALING PROTEIN CRYSTAL STRUCTURE SONIC HEDGEHOG BOUND TO THE 5E1 FAB FRAGMENT MOLECULE: SONIC HEDGEHOG PROTEIN; SYNONYM: SHH, HHG - 1, SONIC HEDGEHOG PROTEIN N - PRODUCT, SONIC HEDGEHOG PROTEIN C - PRODUCT; ENGINEERED: YES; ? ? HOMO SAPIENS 11 KASQSVSNDLT 7 YASNRYT 9 QQDYGSPPT 5 DEALH 17 VIRPYSGETNYNQKFKD 10 DWERGDFFDY crystal 1.83A 18.10% FAB 07-MAY-10 20100507 TRANSFERASE / IMMUNE SYSTEM CRYSTALLOGRAPHIC TRIMER OF HER2 EXTRACELLULAR REGIONS IN COMPLEX WITH TRYPTOPHAN - RICH ANTIBODY FRAGMENT MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; FRAGMENT: UNP RESIDUES 23 - 646; SYNONYM: P185ERBB2, PROTO - ONCOGENE C - ERBB - 2, PROTO - ONCOGENE NEU, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2, METASTATIC LYMPH NODE GENE 19 PROTEIN, MLN 19; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQWWWWPST 5 WSWIH 17 SISPSSGWTSYADSVKG 8 WWSSAMDY crystal 3.20A 20.70% FAB 27-MAY-10 20100527 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE HUMAN NEUTRALIZING ANTI - WEST NILE VIRUS MAB CR4354 ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.43A 16.80% FAB 29-MAY-10 20100529 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB15 ? ? ? HOMO SAPIENS 11 RASQSIGLYLA 7 AASSLQS 9 QQGNTLSYT 5 NYWVG 17 FIDPSDSYTNYAPSFQG 12 ELYQGYMDTFDS crystal 1.70A 16.90% FAB 01-JUN-10 20100601 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB15 MUT5 ? ? ? HOMO SAPIENS 11 RASQSIGLYLA 7 AASSLQS 9 QQGNTLSYT 5 NYWIS 17 FIDPSDSYTNYAPSFQG 12 QLYQGYMDTFDS crystal 1.70A 17.90% FAB 01-JUN-10 20100601 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB15 MUT6 ? ? ? HOMO SAPIENS 11 RASQSIGLYLA 7 AASSLQS 9 QQGNTLSYT 5 NYWIS 17 RIDPSDSYTNYSPSFQG 12 ELYQGYMDTFDS crystal 2.32A 20.60% FAB 01-JUN-10 20100601 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB15 MUT7 ? ? ? HOMO SAPIENS 11 RASQSIGLYLA 7 AASSLQS 9 QQGNTLSYT 5 NYWIS 17 RIDPSDSYTNYSPSFQG 12 QLYQGYMDTFDS crystal 1.80A 18.60% FAB 01-JUN-10 20100601 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB15 MUT8 ? ? ? HOMO SAPIENS 11 RASQSIGLYLA 7 AASSLQS 9 QQGNTLPYT 5 NYWIS 17 FIDPSDSYTNYAPSFQG 12 QLYQGYMDTFDS crystal 1.60A 20.20% FAB 04-JUN-10 20100604 TRANSPORT PROTEIN X - RAY CRYSTAL STRUCTURE OF AN ARGININE AGMATINE ANTIPORTER (ADIC) IN COMPLEX WITH A FAB FRAGMENT MOLECULE: ADIC; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVNYMH 7 DTSKLAS 9 QQWSYNPPT 5 NYDIN 17 WIYPGDGSTMYNEKFKG 11 LDGNYGGWFAY crystal 3.20A 28.30% FAB 06-JUN-10 20100606 IMMUNE SYSTEM / CYTOKINE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THERAPEUTIC ANTIBODY DACLIZUMAB IN COMPLEX WITH IL - 2RA (CD25) ECTODOMAIN MOLECULE: INTERLEUKIN - 2 RECEPTOR SUBUNIT ALPHA; FRAGMENT: UNP RESIDUES 22 - 238; SYNONYM: IL - 2 RECEPTOR SUBUNIT ALPHA, IL - 2R SUBUNIT ALPHA, IL - 2 - RA, IL2 - RA, P55, TAC ANTIGEN, CD_ANTIGEN=CD25; ENGINEERED: YES ? ? HOMO SAPIENS 10 SASSSISYMH 7 TTSNLAS 9 HQRSTYPLT 5 SYRMH 17 YINPSTGYTEYNQKFKD 7 GGGVFDY crystal 2.86A 25.50% FAB 10-JUN-10 20100610 IMMUNE SYSTEM CRYSTAL STRUCTURE THE FAB FRAGMENT OF THERAPEUTIC ANTIBODY DACLIZUMAB ? ? ? HOMO SAPIENS 10 SASSSISYMH 7 TTSNLAS 9 HQRSTYPLT 5 SYRMH 17 YINPSTGYTEYNQKFKD 7 GGGVFDY crystal 2.60A 22.70% FAB 10-JUN-10 20100610 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV - 1 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 DCTLN 17 WLKPRGGAVNYARPLQG 12 GKNCDYNWDFEH crystal 2.68A 20.00% ? 11-JUN-10 20100611 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEUTRALIZING FAB FRAGMENT ABD1556 BOUND TO THE BMP TYPE I RECEPTOR IA MOLECULE: BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE - 1A; FRAGMENT: EXTRACELLULAR DOMAIN, UNP RESIDUES 24 - 152; SYNONYM: BMP TYPE I RECEPTOR, BMPR - IA, BMP TYPE - 1A RECEPTOR, BMPR - 1A, SERINE / THREONINE - PROTEIN KINASE RECEPTOR R5, SKR5, ACTIVIN RECEPTOR - LIKE KINASE 3, ALK - 3; EC: 2.7.11.30; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDSLGSKYVI 7 DDSNRPS 11 STFTMSGNGTV 5 NYTLN 17 YTSSSGSLTGYADSVKG 11 ERWHVRGYFDH crystal 2.70A 23.60% FAB 14-JUN-10 20100614 CELL ADHESION / BLOOD CLOTTING THE CLOSED HEADPIECE OF INTEGRIN ALPHAIIB BETA3 AND ITS COMPLEX WITH AN ALPAHIIB BETA3 - SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING MOLECULE: INTEGRIN BETA - 3; FRAGMENT: INTEGRIN BETA - 3, RESIDUES 27 - 497; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.30A 17.90% ? 15-JUN-10 20100615 CELL ADHESION / BLOOD CLOTTING THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 - SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING MOLECULE: INTEGRIN BETA - 3; FRAGMENT: INTEGRIN BETA - 3, RESIDUES 27 - 497; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.40A 17.60% ? 15-JUN-10 20100615 CELL ADHESION / BLOOD CLOTTING THE CLOSED HEADPIECE OF INTEGRIN IIB 3 AND ITS COMPLEX WITH AN IIB 3 - SPECIFIC ANTAGONIST THAT DOES NOT INDUCE OPENING MOLECULE: INTEGRIN BETA - 3; FRAGMENT: INTEGRIN BETA - 3, RESIDUES 27 - 497; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.25A 17.20% ? 15-JUN-10 20100615 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ENGINEERED ANTIBODY FRAGMENT BASED ON 3D5 ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSLVPPT 7 TSGMGVN 16 HIYWDDDKRYNPSLKS 12 RGGSSHYYAMDY crystal 3.10A 18.60% FV 23-JUN-10 20100623 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF MEMBRANE - TYPE SERINE PROTEASE 1 (MT - SP1) IN COMPLEX WITH THE FAB INHIBITOR S4 MOLECULE: SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN; FRAGMENT: PEPTIDASE S1 DOMAIN (UNP RESIDUES 615 - 855); SYNONYM: SERINE PROTEASE 14, MATRIPTASE, MEMBRANE - TYPE SERINE PROTEASE 1, MT - SP1, PROSTAMIN, SERINE PROTEASE TADG - 15, TUMOR - ASSOCIATED DIFFERENTIALLY - EXPRESSED GENE 15 PROTEIN; EC: 3.4.21.109; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNYVS 7 DNNQRPS 9 QSRDISQYV 5 SYAIS 17 GIIPIFGTANYAQKFQG 17 TFHIRRYRSGYYDKMDH crystal 1.50A 19.00% FAB 29-JUN-10 20100629 IMMUNE SYSTEM CRYSTAL STRUCTURE OF KD - 247 FAB, AN ANTI - V3 ANTIBODY THAT INHIBITS HIV - 1 ENTRY ? ? ? HOMO SAPIENS, MUS MUSCULUS 17 KSSQSLLNSGDQKNYLT 7 WASTGES 9 QNDYSYPWT 5 NSWIG 17 DIYPGGGYTNYNEIFKG 9 GIPGYAMDY crystal 1.55A 18.40% FAB 03-JUL-10 20100703 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 2 NEUTRALIZING FAB FRAGMENT 7C8 ? ? ? MUS MUSCULUS 16 RSSQTIVHSNGYTYLD 7 KVSNRFS 9 FQGSHVPFT 5 TYDIN 17 WIYPGDGSNKYNEKFKD 11 GYGKNVYAMDY crystal 2.70A 22.90% FAB 16-JUL-10 20100716 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - EMMPRIN ANTIBODY 5F6 FAB MOLECULE: 5F6 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS, MUS MUSCULUS 11 KASQSVSNDVA 7 YASNRYT 9 QQDYSSPYT 5 NYWMN 19 QIRLKSYNYATHYAESVKG 5 DGSDY crystal 2.00A 19.70% FAB 16-JUL-10 20100716 IMMUNE SYSTEM / OXIDOREDUCTASE CRYSTAL STRUCTURE OF NITRIC OXIDE REDUCTASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ANTIBODY FRAGMENT MOLECULE: NITRIC OXIDE REDUCTASE SUBUNIT B; SYNONYM: NITRIC OXIDE REDUCTASE CYTOCHROME B SUBUNIT, NOR LARGE SUBUNIT; EC: 1.7.99.7; ? ? MUS MUSCULUS 11 RASKSIRKYLA 7 SGSTLQF 9 QQHNEYPLT 5 SYWMH 17 AVYPGNSDTSYNQKFKG 15 SSLDGYYVKNWCFDV crystal 2.70A 18.80% FAB 20-JUL-10 20100720 IMMUNE SYSTEM ANTI - BETA - AMYLOID ANTIBODY C706 FAB IN SPACE GROUP C2 MOLECULE: C706 LIGHT CHAIN VARIABLE REGION, IG KAPPA CHAIN C REGION CHIMERA; ENGINEERED: YES; KAPPA ? MUS MUSCULUS, HOMO SAPIENS 10 SASSSVSYMH 7 DSSRLAS 8 QNWRSSPT 5 TSWIE 17 EVLPGSGKSNHNANFKG 10 EGSNNNALAY crystal 2.80A 22.30% FAB 20-JUL-10 20100720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 PRIMARY RECEPTOR CD4 IN COMPLEX WITH A POTENT ANTIVIRAL ANTIBODY MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: UNP RESIDUES 26 - 207; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLYSTNQKNYLA 7 WASTRES 8 QQYYSYRT 5 SYVIH 17 YINPYNDGTDYDEKFKG 13 EKDNYATGAWFAY crystal 2.19A 19.40% ? 22-JUL-10 20100722 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 1E9 PHEL89SER / LEUH47TRP / METH100BPHE, AN ENGINEERED DIELS - ALDERASE FAB WITH MODIFIED SPECIFICITY AND CATALYTIC ACTIVITY ? ? ? MUS MUSCULUS, HOMO SAPIENS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVRAFDY crystal 2.30A 19.40% FAB 22-JUL-10 20100722 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 1E9 PHEL89SER / LEUH47TRP / METH100BPHE FAB IN COMPLEX WITH A 39A11 TRANSITION STATE ANALOG WITH A 39A11 TRANSITION STATE ANALOG ? ? MUS MUSCULUS, HOMO SAPIENS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVRAFDY crystal 2.55A 20.90% FAB 22-JUL-10 20100722 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF 101F FAB BOUND TO 15 - MER PEPTIDE EPITOPE MOLECULE: FUSION GLYCOPROTEIN F1; FRAGMENT: RESIDUES 422 - 436; SYNONYM: PROTEIN F; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASQSVDYNGISYMH 7 AASNPES 9 QQIIEDPWT 7 TSGMGVS 16 HIYWDDDKRYNPSLKS 10 LYGFTYGFAY crystal 1.95A 17.90% FAB 26-JUL-10 20100726 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF 101F FAB BOUND TO 17 - MER PEPTIDE EPITOPE MOLECULE: FUSION GLYCOPROTEIN F1; FRAGMENT: UNP RESIDUES 422 - 438; SYNONYM: PROTEIN F; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASQSVDYNGISYMH 7 AASNPES 9 QQIIEDPWT 7 TSGMGVS 16 HIYWDDDKRYNPSLKS 10 LYGFTYGFAY crystal 2.87A 20.30% FAB 26-JUL-10 20100726 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - TAT HIV FAB'11H6H1 ? ? ? MUS MUSCULUS 16 KSGQSLLYSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 SYDMS 17 SISSGGSYTYYPDSVKG 8 DYDYGVDY crystal 2.00A 20.10% FAB 29-JUL-10 20100729 IMMUNE SYSTEM ANTI - TAT HIV 11H6H1 FAB' COMPLEXED WITH A 15 - MER TAT PEPTIDE MOLECULE: PROTEIN TAT 15 - MER PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSGQSLLYSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 SYDMS 17 SISSGGSYTYYPDSVKG 8 DYDYGVDY crystal 2.10A 18.80% FAB 29-JUL-10 20100729 IMMUNE SYSTEM ANTI - TAT HIV 11H6H1 FAB' COMPLEXED WITH A 9 - MER TAT PEPTIDE MOLECULE: PROTEIN TAT 9 - MER PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSGQSLLYSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 SYDMS 17 SISSGGSYTYYPDSVKG 8 DYDYGVDY crystal 2.40A 21.50% FAB 29-JUL-10 20100729 IMMUNE SYSTEM ANTIBODY 2G12 RECOGNIZES DI - MANNOSE EQUIVALENTLY IN DOMAIN - AND NON - DOMAIN - EXCHANGED FORMS, BUT ONLY BINDS THE HIV - 1 GLYCAN SHIELD IF DOMAIN - EXCHANGED ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 1.90A 21.30% FAB 05-AUG-10 20100805 IMMUNE SYSTEM A NON - SELF SUGAR MIMIC OF THE HIV GLYCAN SHIELD SHOWS ENHANCED ANTIGENICITY ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 1.95A 18.40% FAB 05-AUG-10 20100805 IMMUNE SYSTEM A NON - SELF SUGAR MIMIC OF THE HIV GLYCAN SHIELD SHOWS ENHANCED ANTIGENICITY ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 1.75A 17.80% FAB 06-AUG-10 20100806 IMMUNE SYSTEM A NON - SELF SUGAR MIMIC OF THE HIV GLYCAN SHIELD SHOWS ENHANCED ANTIGENICITY ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.85A 23.40% FAB 06-AUG-10 20100806 MEMBRANE PROTEIN KCSA E71A VARIANT IN PRESENCE OF NA+ MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 2 - 124; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.80A 24.90% FAB 16-AUG-10 20100816 FLUORESCENT PROTEIN / IMMUNE SYSTEM STRUCTURE OF THE GFP:GFP - NANOBODY COMPLEX AT 2.8 A RESOLUTION IN SPACEGROUP P21212 MOLECULE: GREEN FLUORESCENT PROTEIN; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 RYSMR 17 GMSSAGDRSSYEDSVKG 6 NVGFEY crystal 2.80A 20.40% HC-dimer 17-AUG-10 20100817 IMMUNE SYSTEM ANTI - INDOLICIDIN MONOCLONAL ANTIBODY V2D2 (FAB FRAGMENT) LIGHT CHAIN; ? ? MUS MUSCULUS 11 KASGNIHNYLA 7 NASTLAD 9 QHFWSTPFT 5 NYGMN 17 WINTYTGEPTYSDDFKG 15 ERDYGSRYRGYALDF crystal 2.00A 20.50% FAB 22-AUG-10 20100822 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 39 IN COMPLEX WITH KDO WITH KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 11 DHDGYYERFAY crystal 1.80A 23.50% FAB 24-AUG-10 20100824 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 39 IN COMPLEX WITH KO WITH KO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 11 DHDGYYERFAY crystal 2.40A 22.50% FAB 24-AUG-10 20100824 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 39 IN COMPLEX WITH KDO (2.4) KDO WITH KDO (2.4) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 11 DHDGYYERFAY crystal 1.95A 19.70% FAB 25-AUG-10 20100825 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 39 IN COMPLEX WITH KDO (2.8) KDO WITH KDO (2.8) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 11 DHDGYYERFAY crystal 1.80A 19.30% FAB 25-AUG-10 20100825 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNLIGANDED S25 - 39 ? ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 11 DHDGYYERFAY crystal 2.40A 23.20% FAB 25-AUG-10 20100825 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 39 IN COMPLEX WITH KDO (2.4) KDO (2.4) KDO WITH KDO (2.4) KDO (2.4) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 11 DHDGYYERFAY crystal 2.15A 21.70% FAB 25-AUG-10 20100825 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 39 IN COMPLEX WITH KDO (2.8) KDO (2.4) KDO WITH KDO (2.8) KDO (2.4) KDO ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKAKGYTTEYSASVKG 11 DHDGYYERFAY crystal 2.45A 21.30% FAB 25-AUG-10 20100825 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF TRANS - SIALIDASE IN COMPLEX WITH THE FAB FRAGMENT OF A NEUTRALIZING MONOCLONAL IGG ANTIBODY MOLECULE: TRANS - SIALIDASE; EC: 3.2.1.18; ENGINEERED: YES; MUTATION: YES; ? IGG MUS MUSCULUS 10 SASSSVSHMH 7 ITSYLAS 9 HQWSTFPST 4 DWIG 17 DIYLGGGYINYNEKFKG 10 GHYDGSYFDY crystal 3.40A 16.50% FAB 02-SEP-10 20100902 IMMUNE SYSTEM / TRANSPORT PROTEIN ON THE STRUCTURAL BASIS OF MODAL GATING BEHAVIOR IN K+CHANNELS - E71Q MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 22 - 124; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.70A 22.60% FAB 06-SEP-10 20100906 IMMUNE SYSTEM / TRANSPORT PROTEIN ON THE STRUCTURAL BASIS OF MODAL GATING BEHAVIOR IN K+CHANNELS - E71I MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; FRAGMENT: UNP RESIDUES 22 - 124; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.30A 26.40% FAB 06-SEP-10 20100906 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - GP41 FAB NC - 1 ? KAPPA IGG2 MUS MUSCULUS 10 SASSSVSYMH 7 STSNLAS 8 HQWSGFYT 5 SYWVE 17 KILPGIGSTSYNEKFKG 10 GYYGPTWFAY crystal 1.60A 19.20% FAB 24-SEP-10 20100924 SIGNALING PROTEIN, HYDROLASE STRUCTURE OF A NANOBODY - STABILIZED ACTIVE STATE OF THE BETA2 ADRENOCEPTOR MOLECULE: BETA - 2 ADRENERGIC RECEPTOR, LYSOZYME; FRAGMENT: UNP P07550 RESIDUES 1 - 230, 263 - 365, UNP P00720 RESIDUES 2 - 161; SYNONYM: ENDOLYSIN, LYSIS PROTEIN, MURAMIDASE; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: BETA - 2 - ADRENERGIC RECEPTOR / T4 - LYSOZYME CHIMERA; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INTMG 16 AIHSGGSTNYANSVKG 12 KDYGAVLYEYDY crystal 3.50A 24.30% HC-dimer 28-SEP-10 20100928 IMMUNE SYSTEM ANTI - EGFR / HER3 FAB DL11 ALONE ? ? ? HOMO SAPIENS 11 RASQDLATDVA 7 SASFLYS 9 QQSEPEPYT 5 GDWIH 17 EISAAGGYTDYADSVKG 12 ESRVSFEAAMDY crystal 2.85A 23.00% FAB 29-SEP-10 20100929 IMMUNE SYSTEM ANTI - EGFR / HER3 FAB DL11 IN COMPLEX WITH DOMAIN III OF EGFR EXTRACELLULAR REGION MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: DOMAIN III, UNP RESIDUES 334 - 540; SYNONYM: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1, PROTO - ONCOGENE C - ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDLATDVA 7 SASFLYS 9 QQSEPEPYT 5 GDWIH 17 EISAAGGYTDYADSVKG 12 ESRVSFEAAMDY crystal 1.80A 18.20% FAB 29-SEP-10 20100929 IMMUNE SYSTEM ANTI - EGFR / HER3 FAB DL11 IN COMPLEX WITH DOMAINS I - III OF THE HER3 EXTRACELLULAR REGION MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 3; FRAGMENT: DOMAINS I - III, UNP RESIDUES 20 - 532; SYNONYM: PROTO - ONCOGENE - LIKE PROTEIN C - ERBB - 3, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER3; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDLATDVA 7 SASFLYS 9 QQSEPEPYT 5 GDWIH 17 EISAAGGYTDYADSVKG 12 ESRVSFEAAMDY crystal 3.70A 24.90% FAB 29-SEP-10 20100929 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CLUSTER II FAB 1281 IN COMPLEX WITH HIV - 1 GP41 ECTODOMAIN MOLECULE: HIV - 1 GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGNNYVY 7 KNNIRPS 12 AAWDDSLSGPYV 5 SYSIS 17 GIVPSSGAAKYAQQFQG 17 DRSRVRYFDRESGWFDP crystal 3.30A 26.20% FAB 04-OCT-10 20101004 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ENGINEERED HUMAN AUTONOMOUS VH DOMAIN IN COMPLEX WITH VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; FRAGMENT: UNP RESIDUES 7 - 110; SYNONYM: ENGINEERED HUMAN AUTONOMOUS VH DOMAIN, VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF; ENGINEERED: YES; ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 DTYIG 17 RIYPTNGYTRYADSVKG 15 HYYGWHPGYGLSYSS crystal 2.41A 19.50% HC-dimer 18-OCT-10 20101018 MALTODEXTRIN BINDING PROTEIN / DE NOVO PRO CRYSTAL STRUCTURE OF MALTOSE BOUND MBP WITH A CONFORMATIONALLY SPECIFIC SYNTHETIC ANTIGEN BINDER (SAB) MOLECULE: MALTOSE - BINDING PERIPLASMIC PROTEIN; SYNONYM: MMBP, MALTODEXTRIN - BINDING PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSYIPVT 5 SSYIH 17 YISSYSGYTSYADSVKG 11 TPWWYWSGLDY crystal 2.10A 17.90% FAB 01-NOV-10 20101101 CARBOHYDRATE - BINDING PROTEIN CRYSTAL STRUCTURE OF S64 - 4 IN COMPLEX WITH PSBP WITH PSBP ? ? MUS MUSCULUS 15 RASKSVSSSVNSYMH 7 LASNLES 8 QHSRELRT 5 DYYMS 19 FIRNKGNGYTTEYSTSVKG 11 DIGYGNSPFAY crystal 2.60A 22.20% FAB 04-NOV-10 20101104 CARBOHYDRATE - BINDING PROTEIN CRYSTAL STRUCTURE OF S64 - 4 IN COMPLEX WITH KDO WITH KDO ? ? MUS MUSCULUS 15 RASKSVSSSVNSYMH 7 LASNLES 8 QHSRELRT 5 DYYMS 18 FIRNKGNGYTTEYSTSVK 11 DIGYGNSPFAY crystal 2.00A 22.90% FAB 04-NOV-10 20101104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 2909 FAB, A QUATERNARY STRUCTURE - SPECIFIC ANTIBODY AGAINST HIV - 1 ? ? ? HOMO SAPIENS 11 GGNNIANKNVH 7 YDDDRPS 11 QVWDSNSDHVV 5 DSTMH 17 LISWNGGRTYYADSVKG 21 DKGDSDYDYNLGYSYFYYMDG crystal 3.33A 24.00% FAB 07-NOV-10 20101107 TRANSPORT PROTEIN MECHANISM OF ACTIVATION GATING IN THE FULL - LENGTH KCSA K+ CHANNEL MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; SYNONYM: KCSA; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDVNTAVA 7 SASFLES 11 QQYYSYSAPVT 5 SYSIH 17 SISSYYSSTYYADSVKG 15 QPSYHMYSWWVALDY crystal 3.80A 28.10% FAB 10-NOV-10 20101110 PROTEIN BINDING / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN TDRD3 IN COMPLEX WITH AN ANTI - TDRD3 FAB MOLECULE: TUDOR DOMAIN - CONTAINING PROTEIN 3; ENGINEERED: YES ? ? HOMO SAPIENS, SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 11 QQHGPFYWLFT 5 SSYMH 17 SISSSYGSTYYADSVKG 17 TVRGSKKPYFSGWAMDY crystal 2.05A 22.40% FAB 19-NOV-10 20101119 IMMUNE SYSTEM EPITOPE CHARACTERIZATION AND CRYSTAL STRUCTURE OF GA101 PROVIDE INSIGHTS INTO THE MOLECULAR BASIS FOR THE TYPE I / TYPE II DISTINCTION OF ANTI - CD20 ANTIBODIES ? ? ? MUS MUSCULUS 16 RSSKSLLHSNGITYLY 7 QMSNLVS 9 AQNLELPYT 5 YSWIN 17 RIFPGDGDTDYNGKFKG 10 NVFDGYWLVY crystal 2.51A 21.00% FAB 24-NOV-10 20101124 IMMUNE SYSTEM EPITOPE CHARACTERIZATION AND CRYSTAL STRUCTURE OF GA101 PROVIDE INSIGHTS INTO THE MOLECULAR BASIS FOR THE TYPE I / TYPE II DISTINCTION OF ANTI - CD20 ANTIBODIES MOLECULE: B - LYMPHOCYTE ANTIGEN CD20; FRAGMENT: LARGE EXTRACELLULAR LOOP (UNP RESIDUES 163 - 187); SYNONYM: B - LYMPHOCYTE SURFACE ANTIGEN B1, BP35, LEUKOCYTE SURFACE ANTIGEN LEU - 16, MEMBRANE - SPANNING 4 - DOMAINS SUBFAMILY A MEMBER 1; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSKSLLHSNGITYLY 7 QMSNLVS 9 AQNLELPYT 5 YSWIN 17 RIFPGDGDTDYNGKFKG 10 NVFDGYWLVY crystal 1.60A 13.90% FAB 24-NOV-10 20101124 IMMUNE SYSTEM / CYTOKINE HIV - 1 NEUTRALIZING ANTIBODY Z13E1 IN COMPLEX WITH EPITOPE DISPLAY PROTEIN MOLECULE: INTERLEUKIN - 22; FRAGMENT: UNP RESIDUES 29 - 179; SYNONYM: IL - 22, CYTOKINE ZCYTO18, IL - 10 - RELATED T - CELL - DERIVED - INDUCIBLE FACTOR, IL - TIF; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSVGRNLG 7 DASNRAT 9 QARLLLPQT 5 NYYWS 16 HIIYGGTTKYNPSLES 17 VAIGVSGFLNYYYYMDV crystal 2.15A 21.00% FAB 17-DEC-10 20101217 IMMUNE SYSTEM / CELL ADHESION CRYSTAL STRUCTURE OF A - DOMAIN IN COMPLEX WITH ANTIBODY MOLECULE: INTEGRIN ALPHA - M; FRAGMENT: UNP RESIDUES 148 - 337; SYNONYM: CD11 ANTIGEN - LIKE FAMILY MEMBER B, CR - 3 ALPHA CHAIN, CELL SURFACE GLYCOPROTEIN MAC - 1 SUBUNIT ALPHA, LEUKOCYTE ADHESION RECEPTOR MO1, NEUTROPHIL ADHERENCE RECEPTOR; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQNLLYSSNQKNYLA 7 WASTRES 9 QQYYSYPLT 5 DIYMQ 17 RIDPANDKTKYDPKFQG 13 EGHYGYDGYAMDY crystal 2.70A 21.20% ? 21-DEC-10 20101221 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB OF HUMAN MAB 2909 SPECIFIC FOR QUATERNARY NEUTRALIZING EPITOPE OF HIV - 1 GP120 ? ? ? HOMO SAPIENS 11 GGNNIANKNVH 7 YDDDRPS 11 QVWDSNSDHVV 5 DSTMH 17 LISWNGGRTYYADSVKG 19 DKGDSDDNLGYSYFYYMDG crystal 3.19A 20.10% FAB 31-DEC-10 20101231 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB OF RHESUS MAB 2.5B SPECIFIC FOR QUATERNARY NEUTRALIZING EPITOPE OF HIV - 1 GP120 ? ? ? MACACA MULATTA 11 GGDNIGSKSVQ 7 ADDERSS 11 QVWDSSSHHML 5 NNHWS 17 LISGSGGSTDYNPSLKS 25 IDVVITSHEDDFGDYYTGEYYGLDS crystal 1.90A 19.30% FAB 31-DEC-10 20101231 IMMUNE SYSTEM / CELL ADHESION CRYSTAL STRUCTURE OF A - DOMAIN IN COMPLEX WITH ANTIBODY MOLECULE: INTEGRIN ALPHA - M; FRAGMENT: UNP RESIDUES 148 - 337; SYNONYM: CD11 ANTIGEN - LIKE FAMILY MEMBER B, CR - 3 ALPHA CHAIN, CELL SURFACE GLYCOPROTEIN MAC - 1 SUBUNIT ALPHA, LEUKOCYTE ADHESION RECEPTOR MO1, NEUTROPHIL ADHERENCE RECEPTOR; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQNLLYSSNQKNYLA 7 WASTRES 9 QQYYSYPLT 5 DIYMQ 17 RIDPANDKTKYDPKFQG 13 EGHYGYDGYAMDY crystal 3.00A 19.60% ? 10-JAN-11 20110110 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMANIZED APO LT3015 ANTI - LYSOPHOSPHATIDIC ACID ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 16 TSGQSLVHINGNTYLH 7 KVSNLFS 9 SQSTHFPFT 5 NYLIE 17 LINPGSDYTNYNENFKG 13 RFGYYGSGNYFDY crystal 2.15A 24.00% FAB 17-JAN-11 20110117 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE LT3015 ANTIBODY FAB FRAGMENT IN COMPLEX WITH LYSOPHOSPHATIDIC ACID (14:0) WITH LYSOPHOSPHATIDIC ACID (14:0) ? ? HOMO SAPIENS 16 TSGQSLVHINGNTYLH 7 KVSNLFS 9 SQSTHFPFT 5 NYLIE 17 LINPGSDYTNYNENFKG 13 RFGYYGSGNYFDY crystal 1.98A 22.30% FAB 17-JAN-11 20110117 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE LT3015 ANTIBODY FAB FRAGMENT IN COMPLEX WITH LYSOPHOSPHATIDIC ACID (18:2) WITH LYSOPHOSPHATIDIC ACID (18:2) ? ? HOMO SAPIENS 16 TSGQSLVHINGNTYLH 7 KVSNLFS 9 SQSTHFPFT 5 NYLIE 17 LINPGSDYTNYNENFKG 13 RFGYYGSGNYFDY crystal 2.51A 21.70% FAB 17-JAN-11 20110117 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN N12 - I2 FAB, AN ADCC AND NEUTRALIZING ANTI - HIV - 1 ENV ANTIBODY ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPET 5 SYGIT 17 GIIPIFDVTNYAQNFQG 14 DSRDFSHYYNIMDV crystal 1.95A 20.50% FAB 20-JAN-11 20110120 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN N12 - I15, AN ADCC AND NON - NEUTRALIZING ANTI - HIV - 1 ENV ANTIBODY ? ? ? HOMO SAPIENS 16 RSSQSLLHTNGFQYLD 7 LGSNRAT 8 MQAKESPT 5 NFYIV 17 VINPFRGDTYFAQKFKG 16 DLEMRDGNNHGSHLEF crystal 2.59A 21.80% FAB 20-JAN-11 20110120 IMMUNE SYSTEM / INHIBITOR STRUCTURAL BASIS FOR LIGAND RECOGNITION AND DISCRIMINATION OF A QUORUM QUENCHING ANTIBODY MOLECULE: AGR AUTOINDUCING PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQRLVHSNGNIYLH 7 KLSSRFS 9 SQTTHVPYT 6 SNYAWN 16 FISSYGTTTYNPSLKS 4 EGDY crystal 2.50A 18.60% ? 24-JAN-11 20110124 IMMUNE SYSTEM STRUCTURAL BASIS FOR LIGAND RECOGNITION AND DISCRIMINATION OF A QUORUM QUENCHING ANTIBODY ? ? ? MUS MUSCULUS 16 RSSQRLVHSNGNIYLH 7 KLSSRFS 9 SQTTHVPYT 6 SNYAWN 16 FISSYGTTTYNPSLKS 4 EGDY crystal 2.78A 19.70% ? 24-JAN-11 20110124 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB DEL2D1, A DELETION VARIANT OF ANTI - INFLUENZA ANTIBODY 2D1 ? ? ? HOMO SAPIENS 13 SGSSSNIGSNTVS 7 GNNERPS 12 AAWDDSLNGFWV 7 TSGMSVS 16 LIDWDDDTYYSSSLKT 14 TLRVSGDYVRDFDL crystal 1.66A 18.40% FAB 25-JAN-11 20110125 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - INFLUENZA FAB 2D1 ? ? ? HOMO SAPIENS 13 SGSSSNIGSNTVS 7 GNNERPS 12 AAWDDSLNGFWV 7 TSGMSVS 19 LIDWDDDTYYITYSSSLKT 11 TLRVYVRDFDL crystal 1.55A 18.10% FAB 26-JAN-11 20110126 IMMUNE SYSTEM ORTHORHOMBIC FORM OF HUMAN IGA1 FAB FRAGMENT, SHARING SAME FV AS IGG ? ? IGG HOMO SAPIENS 16 RSSQSLLRRDGHNDLE 7 LGSTRAS 9 MQNKQTPLT 5 GSNVH 19 RIKRNAESDATAYAASMRG 8 RGDVYNRQ crystal 2.20A 18.40% FV 09-FEB-11 20110209 IMMUNE SYSTEM MONOCLINIC FORM OF HUMAN IGA1 FAB FRAGMENT, SHARING SAME FV AS IGG ? ? IGG HOMO SAPIENS 16 RSSQSLLRRDGHNDLE 7 LGSTRAS 9 MQNKQTPLT 5 GSNVH 19 RIKRNAESDATAYAASMRG 2 RQ crystal 2.30A 18.80% FV 09-FEB-11 20110209 IMMUNE SYSTEM ORTHORHOMBIC FORM OF IGG1 FAB FRAGMENT (IN COMPLEX WITH ANTIGENIC TUBULIN PEPTIDE) SHARING SAME FV AS IGA MOLECULE: PEPTIDE FROM TUBULIN BETA CHAIN; SYNONYM: TUBULIN BETA - 5 CHAIN; ENGINEERED: YES ? IGG1 HOMO SAPIENS 16 RSSQSLLRRDGHNDLE 7 LGSTRAS 9 MQNKQTPLT 5 GSNVH 19 RIKRNAESDATAYAASMRG 3 RGQ crystal 2.20A 19.80% FAB 09-FEB-11 20110209 IMMUNE SYSTEM MONOCLINIC FORM OF IGG1 FAB FRAGMENT (IN COMPLEX WITH ANTIGENIC PEPTIDE) SHARING SAME FV AS IGA MOLECULE: PEPTIDE FROM TUBULIN BETA CHAIN; SYNONYM: TUBULIN BETA - 5 CHAIN; ENGINEERED: YES ? IGG1 HOMO SAPIENS 16 RSSQSLLRRDGHNDLE 7 LGSTRAS 9 MQNKQTPLT 5 GSNVH 19 RIKRNAESDATAYAASMRG 8 RGDVYNRQ crystal 2.30A 17.10% FAB 09-FEB-11 20110209 IMMUNE SYSTEM MONOCLINIC FORM OF IGG1 FAB FRAGMENT (APO FORM) SHARING SAME FV AS IGA ? ? IGG1 HOMO SAPIENS 16 RSSQSLLRRDGHNDLE 7 LGSTRAS 9 MQNKQTPLT 5 GSNVH 19 RIKRNAESDATAYAASMRG 8 RGDVYNRQ crystal 2.40A 16.90% FV 09-FEB-11 20110209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - TLR3 ANTIBODY C1068 FAB MOLECULE: C1068 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS, MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 QHFWSTPFT 5 TYWIH 17 EINPNNGRINYNEKFKT 10 VGVMITTFPY crystal 1.90A 20.40% FAB 14-FEB-11 20110214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB C2507 ? ? ? HOMO SAPIENS, RATTUS NORVEGICUS 11 KASQNIYNYLN 7 YTDRLQT 8 QQYNSRDT 5 ANWLN 17 SISPDGGSTSYSDTVKG 10 RATRVSPFDY crystal 2.00A 22.70% FAB 14-FEB-11 20110214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - HUMAN RSV (RESPIRATORY SYNCYTIAL VIRUS) F PROTEIN MAB 101F MOLECULE: 101F LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS, MUS MUSCULUS 15 RASQSVDYNGISYMH 7 AASNPES 9 QQIIEDPWT 7 TSGMGVS 16 HIYWDDDKRYNPSLKS 10 LYGFTYGFAY crystal 1.64A 17.50% FAB 15-FEB-11 20110215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIRSVF FAB B21M ? ? ? HOMO SAPIENS 15 RASQSVDYNGISYMH 7 AASNPES 9 QQIIEDPWT 7 TSGMGVS 16 HIYWDDDKRYNPSLKS 10 LYGFTYGFAY crystal 1.70A 16.20% FAB 17-FEB-11 20110217 HYDROLASE / IMMUNE SYSTEM 5 HISTIDINE VARIANT OF THE ANTI - RNASE A VHH IN COMPLEX WITH RNASE A MOLECULE: RIBONUCLEASE PANCREATIC; SYNONYM: RNASE 1, RNASE A; EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 HPYIY 17 VAAMDSGGGGTLYADSV 14 AAGGHHLRDHTYGQ crystal 1.75A 18.70% HC-dimer 21-FEB-11 20110221 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN PROSTATE SPECIFIC ANTIGEN (PSA) IN FAB SANDWICH WITH A HIGH AFFINITY AND A PCA SELECTIVE ANTIBODY MOLECULE: PROSTATE - SPECIFIC ANTIGEN; SYNONYM: PSA, GAMMA - SEMINOPROTEIN, SEMININ, KALLIKREIN - 3, P - 30 ANTIGEN, SEMENOGELASE; EC: 3.4.21.77; ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPVT 5 SYWMH 17 YINPSTGYTENNQKFKD 8 SGRLYFDV crystal 3.20A 20.30% FAB 24-FEB-11 20110224 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MOTAVIZUMAB EPITOPE - SCAFFOLD BOUND TO MOTAVIZUMAB FAB MOLECULE: MOTAVIZUMAB EPITOPE SCAFFOLD; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSRVGYMH 7 DTSKLAS 9 FQGSGYPFT 7 TAGMSVG 16 DIWWDDKKHYNPSLKD 10 DMIFNFYFDV crystal 1.90A 19.00% FAB 28-FEB-11 20110228 IMMUNE SYSTEM STRUCTURE OF AN ANTI - METHOTREXATE CDR1 - 3 GRAFT VHH ANTIBODY IN COMPLEX WITH METHOTREXATE MOLECULE: ANTI - METHOTREXATE CDR1 - 3 GRAFT VHH; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SWAMA 17 KISGDGRLTTYGDSVKG 15 DDNYVTASWRSGPDY crystal 1.70A 17.60% HC-dimer 02-MAR-11 20110302 IMMUNE SYSTEM FREE STRUCTURE OF AN ANTI - METHOTREXATE CDR1 - 3 GRAFT VHH ANTIBODY MOLECULE: ANTI - METHOTREXATE CDR1 - 3 GRAFT; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 3 AMA 17 KISGDGRLTTYGDSVKG 15 DDNYVTASWRSGPDY crystal 1.80A 18.30% HC-dimer 02-MAR-11 20110302 IMMUNE SYSTEM STRUCTURE OF AN ANTI - METHOTREXATE CDR1 - 4 GRAFT VHH ANTIBODY IN COMPLEX WITH METHOTREXATE MOLECULE: ANTI - METHOTREXATE CDR1 - 4 GRAFT VHH; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SWAMA 17 KISGDGRLTTYGDSVKG 15 DDNYVTASWRSGPDY crystal 2.50A 23.20% HC-dimer 02-MAR-11 20110302 IMMUNE SYSTEM FREE STRUCTURE OF AN ANTI - METHOTREXATE CDR1 - 4 GRAFT VHH ANTIBODY MOLECULE: ANTI - METHOTREXATE CDR1 - 4 GRAFT VHH; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SWAMA 17 KISGDGRLTTYGDSVKG 15 DDNYVTASWRSGPDY crystal 1.85A 19.20% HC-dimer 02-MAR-11 20110302 IMMUNE SYSTEM STRUCTURE OF A DIMERIC ANTI - HER2 SINGLE DOMAIN ANTIBODY ? ? IGG HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 AYDMA 17 AISSSGGSTYYADSVKG 16 LPDLCPGDNCTYPDAS crystal 1.60A 20.90% HC-dimer 03-MAR-11 20110303 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MOUSE CD3EPSILON ANTIBODY 2C11 FAB FRAGMENT ? ? ? CRICETULUS MIGRATORIUS 11 QASQDISNYLN 7 YTNKLAD 9 QQYYNYPWT 5 GYGMH 17 YITSSSINIKYADAVKG 7 FDWDKNY crystal 2.50A 19.30% FAB 07-MAR-11 20110307 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOUSE CD3EPSILON IN COMPLEX WITH ANTIBODY 2C11 FAB MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN; SYNONYM: T - CELL SURFACE ANTIGEN T3 / LEU - 4 EPSILON CHAIN; ENGINEERED: YES ? ? CRICETULUS MIGRATORIUS 11 QASQDISNYLN 7 YTNKLAD 9 QQYYNYPWT 5 GYGMH 17 YITSSSINIKYADAVKG 7 FDWDKNY crystal 4.10A 22.40% FAB 07-MAR-11 20110307 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV LLAMA VHH ANTIBODY A12 MOLECULE: LLAMA VHH A12; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYDMG 17 AISWSGGTTDYADSVKG 18 KWRPLRYSDYPSNSDYYD crystal 1.50A 19.40% HC-dimer 08-MAR-11 20110308 PROTEIN BINDING STRUCTURE BASIS OF ALLOSTERIC INHIBITION OF BACE1 BY AN EXOSITE - BINDING ANTIBODY MOLECULE: BETA - SECRETASE 1; FRAGMENT: CATALYTIC DOMAIN; SYNONYM: ASPARTYL PROTEASE 2, ASP2, ASP 2, BETA - SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA - SITE APP CLEAVING ENZYME 1, MEMAPSIN - 2, MEMBRANE - ASSOCIATED ASPARTIC PROTEASE 2; EC: 3.4.23.46; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQFPTYLPT 5 GYGIH 17 WISPAGGSTDYADSVKG 10 GPFSPWVMDY crystal 2.80A 22.40% FAB 10-MAR-11 20110310 IMMUNE SYSTEM BISPECIFIC DIGOXIGENIN BINDING ANTIBODIES FOR TARGETED PAYLOAD DELIVERY ? ? ? MUS MUSCULUS 11 RASQDIKNYLN 7 YSSTLLS 9 QQSITLPPT 5 DYAMS 17 SINIGATYAYYPDSVKG 16 PGSPYEYDKAYYSMAY crystal 2.80A 20.50% FAB 27-MAR-11 20110327 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH THE FAB FRAGMENT OF ANTIBODY HB7 MOLECULE: ADP - RIBOSYL CYCLASE 1; FRAGMENT: EXTRACELLULAR DOMAIN, RESIDUES 46 - 300; SYNONYM: CYCLIC ADP - RIBOSE HYDROLASE 1, CADPR HYDROLASE 1, T10; EC: 3.2.2.5; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASEDIYNRLA 7 GATSLET 8 QQYWSTPT 5 SYGVH 16 VIWRGGSTDYNAAFMS 11 TLITTGYAMDY crystal 3.04A 20.80% FAB 28-MAR-11 20110328 TRANSPORT PROTEIN / IMMUNE SYSTEM C. ELEGANS GLUTAMATE - GATED CHLORIDE CHANNEL (GLUCL) IN COMPLEX WITH FAB AND IVERMECTIN MOLECULE: AVERMECTIN - SENSITIVE GLUTAMATE - GATED CHLORIDE CHANNEL GLUCL ALPHA; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSTGAVTTINFAN 7 GINNRAP 9 ALWYSNHWV 5 GYTMN 17 LINPYNGGTSYNQKFKG 13 DGDYYRYGRYFDY crystal 3.26A 24.00% FAB 12-APR-11 20110412 TRANSPORT PROTEIN / IMMUNE SYSTEM C. ELEGANS GLUTAMATE - GATED CHLORIDE CHANNEL (GLUCL) IN COMPLEX WITH FAB, IVERMECTIN AND PICROTOXIN MOLECULE: AVERMECTIN - SENSITIVE GLUTAMATE - GATED CHLORIDE CHANNEL GLUCL ALPHA; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSTGAVTTINFAN 7 GINNRAP 9 ALWYSNHWV 5 GYTMN 17 LINPYNGGTSYNQKFKG 13 DGDYYRYGRYFDY crystal 3.40A 23.30% FAB 12-APR-11 20110412 TRANSPORT PROTEIN / IMMUNE SYSTEM C. ELEGANS GLUTAMATE - GATED CHLORIDE CHANNEL (GLUCL) IN COMPLEX WITH FAB, IVERMECTIN AND IODIDE. MOLECULE: AVERMECTIN - SENSITIVE GLUTAMATE - GATED CHLORIDE CHANNEL GLUCL ALPHA; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSTGAVTTINFAN 7 GINNRAP 9 ALWYSNHWV 5 GYTMN 17 LINPYNGGTSYNQKFKG 13 DGDYYRYGRYFDY crystal 3.80A 26.70% FAB 13-APR-11 20110413 TRANSPORT PROTEIN / IMMUNE SYSTEM C. ELEGANS GLUTAMATE - GATED CHLORIDE CHANNEL (GLUCL) IN COMPLEX WITH FAB, IVERMECTIN AND GLUTAMATE. MOLECULE: AVERMECTIN - SENSITIVE GLUTAMATE - GATED CHLORIDE CHANNEL GLUCL ALPHA; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSTGAVTTINFAN 7 GINNRAP 9 ALWYSNHWV 5 GYTMN 17 LINPYNGGTSYNQKFKG 13 DGDYYRYGRYFDY crystal 3.35A 24.90% FAB 13-APR-11 20110413 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV LLAMA VHH ANTIBODY A12 IN COMPLEX WITH C186 GP120 MOLECULE: C186 GP120; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYDMG 17 AISWSGGTTDYADSVKG 18 KWRPLRYSDYPSNSDYYD crystal 2.60A 25.70% HC-dimer 15-APR-11 20110415 VIRAL PROTEIN / IMMUNE SYSTEM HEPATITIS E VIRUS E2S DOMAIN (GENOTYPE I) IN COMPLEX WITH A NEUTRALIZING ANTIBODY MOLECULE: CAPSID PROTEIN; FRAGMENT: UNP RESIDUES 459 - 603; SYNONYM: PROTEIN ORF2, PORF2; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASEIIYSNLA 7 SATNLAE 9 QHFWGNPWT 7 TSGMGVG 16 HIWWDDVKRYSPALKS 14 IKSVITTGDYALDY crystal 1.90A 18.90% ? 18-APR-11 20110418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FROM 3BNC60, HIGHLY POTENT ANTI - HIV ANTIBODY ? ? ? HOMO SAPIENS 7 QANGYLN 7 DGSKLER 8 QVYEFIVP 5 DHFIH 19 WINPKTGQPNNPRQFQGRV 12 ARQRSDFWDFDV crystal 2.65A 21.00% FAB 26-APR-11 20110426 DE NOVO PROTEIN, IMMUNE SYSTEM STRUCTURE OF AN HIV EPITOPE SCAFFOLD IN COMPLEX WITH NEUTRALIZING ANTIBODY B12 FAB MOLECULE: EPITOPE SCAFFOLD 2BODX43; ENGINEERED: YES; ? ? HOMO SAPIENS 17 RTPVIRNRIASVPQGTW 7 LMSAAQA 15 AGLKNRPAYIIVYPL 5 NFVIH 17 WINPYNGNKEFSAKFQD 18 VGPYSWDDSPQDNYYMDV crystal 2.07A 17.00% FAB 04-MAY-11 20110504 IMMUNE SYSTEM STRUCTURE OF 4C1 FAB IN P212121 SPACE GROUP ? ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 2.05A 19.50% FAB 06-MAY-11 20110506 IMMUNE SYSTEM STRUCTURE OF 4C1 FAB IN C2221 SPACE GROUP ? ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 2.50A 21.40% FAB 06-MAY-11 20110506 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DER F 1 COMPLEXED WITH FAB 4C1 MOLECULE: PEPTIDASE 1; FRAGMENT: UNP RESIDUES 99 - 321; SYNONYM: ALLERGEN DER F I, MAJOR MITE FECAL ALLERGEN DER F 1; EC: 3.4.22.65; ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 1.90A 15.30% FAB 06-MAY-11 20110506 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1 MOLECULE: PEPTIDASE 1; FRAGMENT: UNP RESIDUES 99 - 320; SYNONYM: ALLERGEN DER P I, MAJOR MITE FECAL ALLERGEN DER P 1; EC: 3.4.22.65; ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 1.95A 15.80% FAB 06-MAY-11 20110506 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1 MOLECULE: PEPTIDASE 1; FRAGMENT: UNP RESIDUES 99 - 320; SYNONYM: ALLERGEN DER P I, MAJOR MITE FECAL ALLERGEN DER P 1; EC: 3.4.22.65; ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 2.50A 18.00% FAB 06-MAY-11 20110506 IMMUNE SYSTEM COMPLEX OF FCGAMMARIIA (CD32) AND THE FC OF HUMAN IGG1 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_CELL_LINE: NS0 MURINE MYELOMA CELLS; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD32, FCG2, FCGR2A, FCGR2A1, IGFR2; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; EXPRESSION_SYSTEM_TAXID: 7108; EXPRESSION_SYSTEM_CELL_LINE: SF21; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PVL1392 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.80A 25.20% FC 11-MAY-11 20110511 IMMUNE SYSTEM STRUCTURE OF THE 1121B FAB FRAGMENT ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQGIDNWLG 7 DASNLDT 9 QQAKAFPPT 5 SYSMN 17 SISSSSSYIYYADSVKG 7 VTDAFDI crystal 2.20A 18.50% FAB 17-MAY-11 20110517 IMMUNE SYSTEM / TRANSFERASE STRUCTURAL BASIS FOR THE FUNCTION OF TWO ANTI - VEGF RECEPTOR ANTIBODIES MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2; FRAGMENT: DOMAIN 3 OF VEGF RECEPTOR 2, UNP RESIDUES 220 - 338; SYNONYM: VEGFR - 2, FETAL LIVER KINASE 1, FLK - 1, KINASE INSERT DOMAIN RECEPTOR, PROTEIN - TYROSINE KINASE RECEPTOR FLK - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQSNEDPLT 5 EYIIH 17 WLYPESNIIKYNEKFKD 8 HDGTNFDY crystal 2.20A 20.60% FAB 17-MAY-11 20110517 IMMUNE SYSTEM / TRANSFERASE STRUCTURAL BASIS FOR THE FUNCTION OF TWO ANTI - VEGF RECEPTOR ANTIBODIES MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2; FRAGMENT: DOMAIN 3 OF VEGF RECEPTOR 2, UNP RESIDUES 220 - 338; SYNONYM: VEGFR - 2, FETAL LIVER KINASE 1, FLK - 1, KINASE INSERT DOMAIN RECEPTOR, PROTEIN - TYROSINE KINASE RECEPTOR FLK - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQGIDNWLG 7 DASNLDT 9 QQAKAFPPT 5 SYSMN 17 SISSSSSYIYYADSVKG 7 VTDAFDI crystal 3.20A 27.70% ? 17-MAY-11 20110517 IMMUNE SYSTEM / TRANSFERASE STRUCTURAL BASIS FOR THE FUNCTION OF TWO ANTI - VEGF RECEPTOR ANTIBODIES MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2; FRAGMENT: DOMAIN 3 OF VEGF RECEPTOR 2, UNP RESIDUES 220 - 338; SYNONYM: VEGFR - 2, FETAL LIVER KINASE 1, FLK - 1, KINASE INSERT DOMAIN RECEPTOR, PROTEIN - TYROSINE KINASE RECEPTOR FLK - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQGIDNWLG 7 DASNLDT 9 QQAKAFPPT 5 SYSMN 17 SISSSSSYIYYADSVKG 7 VTDAFDI crystal 2.70A 28.40% FAB 17-MAY-11 20110517 IMMUNE SYSTEM STRUCTURE OF FAB FRAGMENT OF MALARIA TRANSMISSION BLOCKING ANTIBODY 2A8 AGAINST P. VIVAX P25 PROTEIN ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSSNPPT 5 SYWMH 17 MIHPHSGSTNYNEKFKS 6 GADVAY crystal 4.01A 26.60% FAB 24-MAY-11 20110524 IMMUNE SYSTEM AGLYCOSYLATED HUMAN IGG1 FC FRAGMENT ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1, IGHM; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: DH10B; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PTRC 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.13A 26.20% FC 26-MAY-11 20110526 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 3B5H10 ? ? ? MUS MUSCULUS 12 TLNSQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 TYGMS 17 WINTYSGVPTYVDDFKG 10 GGDNYLWFAY crystal 1.90A 18.70% FAB 31-MAY-11 20110531 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR8020 BOUND TO THE INFLUENZA A H3 HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: UNP RESIDUES 346 - 521; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSMNYLA 7 GASRRAT 9 QQYGTSPRT 5 SFGVS 17 WISAYNGDTYYAQKFQA 13 EPPLFYSSWSLDN crystal 2.85A 20.30% ? 09-JUN-11 20110609 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC03 IN COMPLEX WITH HIV - 1 GP120 MOLECULE: HIV - 1 CLADE AE STRAIN 93TH057 GP120; FRAGMENT: CORE GP120 WITH TRUNCATIONS; ENGINEERED: YES; ? ? HOMO SAPIENS 10 KASQGGNAMT 7 DTSRRAS 5 QQFEF 5 DYSIH 17 WIKPLWGAVSYARQLQG 26 TPADTAEYFCVRRGSCDYCGDFPWQY crystal 1.90A 18.90% ? 10-JUN-11 20110610 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC - PG04 IN COMPLEX WITH HIV - 1 GP120 MOLECULE: HIV - 1 CLADE AE STRAIN 93TH057 GP120; FRAGMENT: CORE GP120 WITH TRANCATIONS; ENGINEERED: YES; ? ? HOMO SAPIENS 9 TAASYGHMT 7 ATSKRAS 5 QQLEF 6 RTELIH 18 WVKTVTGAVNFGSPDFRQ 14 QKFYTGGQGWYFDL crystal 2.00A 19.20% ? 10-JUN-11 20110610 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MOUSE MAB 17.2 MOLECULE: LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGSHFPYT 5 TNAMN 19 RIRSKINNYSTYYADSVKD 4 GTTY crystal 2.31A 17.60% ? 14-JUN-11 20110614 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MAB 17.2 IN COMPLEX WITH R13 PEPTIDE MOLECULE: R13 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGSHFPYT 5 TNAMN 19 RIRSKINNYSTYYADSVKD 4 GTTY crystal 1.89A 18.10% ? 14-JUN-11 20110614 IMMUNE SYSTEM UNIQUE CARBOHYDRATE - CARBOHYDRATE INTERACTIONS ARE REQUIRED FOR HIGH AFFINITY BINDING BETWEEN FCGIII AND ANTIBODIES LACKING CORE FUCOSE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD16A, FCG3, FCGR3, FCGR3A, IGFR3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 19.80% FC 15-JUN-11 20110615 IMMUNE SYSTEM UNIQUE CARBOHYDRATE / CARBOHYDRATE INTERACTIONS ARE REQUIRED FOR HIGH AFFINITY BINDING OF FCGIII AND ANTIBODIES LACKING CORE FUCOSE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A, CD16A, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 20.70% FC 15-JUN-11 20110615 IMMUNE SYSTEM STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF AN AGONISTIC ANTI - HUMAN EPHA2 MONOCLONAL ANTIBODY MOLECULE: EPHRIN TYPE - A RECEPTOR 2; FRAGMENT: UNP RESIDUES 23 - 202; SYNONYM: EPITHELIAL CELL KINASE, TYROSINE - PROTEIN KINASE RECEPTOR ECK; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISTWLA 7 KASNLHT 9 QQYNSYSRT 5 HYMMA 17 RIGPSGGPTHYADSVKG 19 YDSGYDYVAVAGPAEYFQH crystal 2.50A 21.90% FAB 22-JUN-11 20110622 SIGNALING PROTEIN / HYDROLASE CRYSTAL STRUCTURE OF THE BETA2 ADRENERGIC RECEPTOR - GS PROTEIN COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY crystal 3.20A 22.80% HC-dimer 28-JUN-11 20110628 HYDROLASE STRUCTURES OF FAB - PROTEASE COMPLEXES REVEAL A HIGHLY SPECIFIC NON - CANONICAL MECHANISM OF INHIBITION. MOLECULE: SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN; FRAGMENT: PEPTIDASE S1 DOMAIN; SYNONYM: MATRIPTASE, MEMBRANE - TYPE SERINE PROTEASE 1, MT - SP1, PROSTAMIN, SERINE PROTEASE 14, SERINE PROTEASE TADG - 15, TUMOR - ASSOCIATED DIFFERENTIALLY - EXPRESSED GENE 15 PROTEIN; EC: 3.4.21.109; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASTRAT 11 QQRSNWPPGYT 5 SYAMS 17 AISGSGGSTYYADSVKG 16 DLGIAARRFVSGAFDI crystal 2.10A 16.20% FAB 29-JUN-11 20110629 PROTEIN BINDING / IMMUNE SYSTEM THE STRUCTURE OF THE FIRST YWTD BETA PROPELLER DOMAIN OF LRP6 IN COMPLEX WITH A FAB MOLECULE: LOW - DENSITY LIPOPROTEIN RECEPTOR - RELATED PROTEIN 6; FRAGMENT: UNP RESIDUES 20 - 335; SYNONYM: LRP - 6; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSYTTPPT 5 NSYIH 17 WITPYGGYTNYADSVKG 17 GSGHVNAVKNYGYVMDY crystal 1.90A 17.60% FAB 30-JUN-11 20110630 HYDROLASE / IMMUNE SYSTEM PCSK9 J16 FAB COMPLEX MOLECULE: PCSK9 PRODOMAIN; SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1, NARC - 1, PROPROTEIN CONVERTASE 9, PC9, SUBTILISIN / KEXIN - LIKE PROTEASE PC9; EC: 3.4.21. -; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGISSALA 7 SASYRYT 9 QQRYSLWRT 5 SYYMH 17 EISPFGGRTNYNEKFKS 9 ERPLYASDL crystal 2.70A 22.60% FAB 05-JUL-11 20110705 RNA BINDING PROTEIN / IMMUNE SYSTEM A COMPLEX OF TWO EDITOSOME PROTEINS AND TWO NANOBODIES MOLECULE: RNA - EDITING COMPLEX PROTEIN MP42; FRAGMENT: UNP RESIDUES 247 - 393; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 16 AINRSGSTFYADAVKG 18 DRFSPVVPGPIPVNTVDS crystal 2.50A 20.10% HC-dimer 09-JUL-11 20110709 MEMBRANE PROTEIN KCSA POTASSIUM CHANNEL MUTANT Y82C WITH CADMIUM BOUND MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.40A 22.70% FAB 11-JUL-11 20110711 MEMBRANE PROTEIN KCSA POTASSIUM CHANNEL MUTANT Y82C WITH NITROXIDE SPIN LABEL MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.50A 24.60% FAB 11-JUL-11 20110711 IMMUNE SYSTEM S25 - 2 - A (2 - 8) - A (2 - 4) KDO TRISACCHARIDE COMPLEX IMMUNE SYSTEM S25 - 2 - A (2 - 8) - A (2 - 4) KDO TRISACCHARIDE COMPLEX ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.49A 19.00% FAB 15-JUL-11 20110715 DYE - BINDING PROTEIN UNLIGANDED FLUOROGEN ACTIVATING PROTEIN M8VL ? LAMBDA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: MACHTI; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PAK400 13 SGSSSNVEDNSVY 7 NDDRRSS 11 LSWDDSLNGWV 0 N/A 0 N/A 0 N/A crystal 1.45A 18.10% LC-dimer 20-JUL-11 20110720 DYE - BINDING PROTEIN FLUOROGEN ACTIVATING PROTEIN M8VL IN COMPLEX WITH DIMETHYLINDOLE RED WITH DIMETHYLINDOLE RED LAMBDA ? HOMO SAPIENS 13 SGSSSNVEDNSVY 7 NDDRRSS 11 LSWDDSLNGWV 0 N/A 0 N/A 0 N/A crystal 1.50A 15.00% LC-dimer 20-JUL-11 20110720 DYE - BINDING PROTEIN FLUOROGEN ACTIVATING PROTEIN M8VLA4 (S55P) IN COMPLEX WITH DIMETHYLINDOLE RED WITH DIMETHYLINDOLE RED LAMBDA ? HOMO SAPIENS 13 SGSSSNVEDNSVY 7 NDDRRPS 11 LSWDDSLNGWV 0 N/A 0 N/A 0 N/A crystal 1.96A 21.10% LC-dimer 20-JUL-11 20110720 HYDROLASE HUMAN HEPSIN PROTEASE IN COMPLEX WITH THE FAB FRAGMENT OF AN INHIBITORY ANTIBODY MOLECULE: SERINE PROTEASE HEPSIN; FRAGMENT: EXTRACELLULAR DOMAIN (UNP RESIDUES 46 - 417); SYNONYM: TRANSMEMBRANE PROTEASE SERINE 1, SERINE PROTEASE HEPSIN NON - CATALYTIC CHAIN, SERINE PROTEASE HEPSIN CATALYTIC CHAIN; EC: 3.4.21.106; ENGINEERED: YES; ? ? HOMO SAPIENS 14 RSSTGAVTTSNYAN 7 DTNNRAP 9 ALWYSNHFI 5 DYSMR 17 WINTETGSPTYADDFKG 4 GFAY crystal 2.55A 24.40% FAB 22-JUL-11 20110722 CELL ADHESION A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 27 - 498; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.60A 18.00% ? 25-JUL-11 20110725 CELL ADHESION A NOVEL HIGH AFFINITY INTEGRIN ALPHAIIBBETA3 RECEPTOR ANTAGONIST THAT UNEXPECTEDLY DISPLACES MG2+ FROM THE BETA3 MIDAS MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 27 - 498; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.20A 18.90% ? 25-JUL-11 20110725 IMMUNE SYSTEM S25 - 2 - KDO MONOSACCHARIDE COMPLEX IMMUNE SYSTEM S25 - 2 - KDO MONOSACCHARIDE COMPLEX ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.73A 19.80% FAB 26-JUL-11 20110726 IMMUNE SYSTEM S25 - 2 - A (2 - 8) KDO DISACCHARIDE COMPLEX IMMUNE SYSTEM S25 - 2 - A (2 - 8) KDO DISACCHARIDE COMPLEX ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.45A 19.50% FAB 28-JUL-11 20110728 IMMUNE SYSTEM S25 - 2 - A (2 - 4) KDO DISACCHARIDE COMPLEX IMMUNE SYSTEM S25 - 2 - A (2 - 4) KDO DISACCHARIDE COMPLEX ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 11 DHDGYYERFSY crystal 1.74A 20.90% FAB 29-JUL-11 20110729 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING ANTIBODY CH04 ? ? ? HOMO SAPIENS 12 RASQSVHSRYFA 7 GGSTRAT 9 QQYGRSPYT 5 NFGFG 17 GTNWNGGDSRYGDSVKG 24 GTDYTIDDQGIRYQGSGTFWYFDV crystal 1.91A 19.80% FAB 09-AUG-11 20110809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAS RECEPTOR EXTRACELLULAR DOMAIN IN COMPLEX WITH FAB EP6B_B01 MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; FRAGMENT: EXTRACELLULAR DOMAIN; SYNONYM: APO - 1 ANTIGEN, APOPTOSIS - MEDIATING SURFACE ANTIGEN FAS, FASLG RECEPTOR; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGNSSNIGRYPVN 7 SDNLRFS 11 STWDDTLEGWV 7 ANSYYGV 19 SIAYRGNSNSGSTYYNPSL 19 ARRQLLDDGTGYQWAAFDV crystal 2.10A 18.50% FAB 19-AUG-11 20110819 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAS RECEPTOR EXTRACELLULAR DOMAIN IN COMPLEX WITH FAB E09 MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; SYNONYM: APO - 1 ANTIGEN, APOPTOSIS - MEDIATING SURFACE ANTIGEN FAS, FASLG RECEPTOR; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGNSFNIGRYPVN 7 YNNLRFS 11 STWDDTLKGWV 7 ANSYYGV 19 SIAYRGNSNSGSTYYNPSL 19 ARRQLLDDGTGYQWAAFDV crystal 1.93A 20.60% FAB 24-AUG-11 20110824 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A32 FAB, AN ADCC MEDIATING ANTI - HIV - 1 ANTIBODY ? ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNNRPS 10 SSYTDIHNFV 7 SGAHYWS 16 YIHYSGNTYYNPSLKS 13 GTRLRTLRNAFDI crystal 1.85A 19.00% FAB 01-SEP-11 20110901 IMMUNE SYSTEM CRYSTAL STRUCTURE OF N5 - I5 FAB, AN ADCC MEDIATING AND NON - NEUTRALIZING CD4I ANTI - HIV - 1 ANTIBODY. ? ? ? HOMO SAPIENS 14 TGTSSDVGSYNFVS 7 EVSERPS 11 SSYAGSTTFRV 5 TYAMS 17 SINNSGRNTFSADSVKG 10 DLRLGGGSDY crystal 1.95A 20.00% FAB 01-SEP-11 20110901 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE OLIGOMER - SPECIFIC KW1 ANTIBODY FRAGMENT ? ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 QEFVI 19 VSGISLRKGWTYYADSVKG 12 APTATHALYFDY crystal 1.30A 14.30% HC-dimer 08-SEP-11 20110908 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF LEUT IN THE OUTWARD - OPEN CONFORMATION IN COMPLEX WITH FAB MOLECULE: LEUCINE TRANSPORTER LEUT; ENGINEERED: YES; MUTATION: YES; KAPPA ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 GASNLES 9 QQSNEDPYT 5 DYYIN 17 EIYPGVGTTYYDEKFKG 12 RTVTMGRYAMDY crystal 3.10A 22.00% FAB 13-SEP-11 20110913 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF LEUT IN THE INWARD - OPEN CONFORMATION IN COMPLEX WITH FAB MOLECULE: LEUCINE TRANSPORTER LEUT; ENGINEERED: YES; MUTATION: YES; KAPPA ? MUS MUSCULUS 15 RASESVDTYDNSFIH 7 RASNLES 9 QQSNEDPLT 5 NHHIN 17 YIIPYNDYTTNNRKFKG 9 GNYGAWFAY crystal 3.22A 25.90% FAB 13-SEP-11 20110913 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROAD AND POTENT HIV - 1 NEUTRALIZING ANTIBODY PGT128 IN COMPLEX WITH MAN9 MOLECULE: PGT128 LIGHT CHAIN, IG LAMBDA - 2 CHAIN C REGIONS; FRAGMENT: PGT128 LIGHT CHAIN; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.29A 15.90% FAB 19-SEP-11 20110919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROAD AND POTENT HIV - 1 NEUTRALIZING ANTIBODY PGT127 IN COMPLEX WITH MAN9 MOLECULE: PGT127 LIGHT CHAIN, IG LAMBDA - 2 CHAIN C REGIONS; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.65A 19.30% FAB 21-SEP-11 20110921 IMMUNE SYSTEM, VIRAL PROTEIN CRYSTAL STRUCTURE OF BROAD AND POTENT HIV - 1 NEUTRALIZING ANTIBODY PGT128 IN COMPLEX WITH A GLYCOSYLATED ENGINEERED GP120 OUTER DOMAIN WITH MINIV3 (EODMV3) MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 3.25A 20.90% FAB 25-SEP-11 20110925 IMMUNE SYSTEM FAB - ANTIBODY COMPLEX MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: UNP RESIDUES 701 - 711; ENGINEERED: YES ? ? HOMO SAPIENS 16 KSSQSLLYSDAKTYLN 7 QISRLDP 9 LQGTHYPVL 5 AYYIH 17 RIDPATGNTKYAPRLQD 7 LYSLPVY crystal 2.50A 22.00% FAB 29-SEP-11 20110929 IMMUNE SYSTEM AD RELATED MURINE ANTIBODY FRAGMENT ? KAPPA ? MUS MUSCULUS, HOMO SAPIENS 11 SASQGISNYLN 7 YTSSLHS 9 QQYRKLPYT 5 RYWMN 17 EINPDSSTINYTPSLKD 4 QMGY crystal 2.00A 19.10% FAB 29-SEP-11 20110929 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PGT145, A BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 16 KCSHSLQHSTGANYLA 7 LATHRAS 9 MQGLHSPWT 5 NHDVH 19 WMSHEGDKTGLAQKFQGRV 26 GSKHRLRDYFLNEGPNYEEWGDYLAT crystal 2.30A 19.60% FAB 30-SEP-11 20110930 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PG9 FAB IN COMPLEX WITH V1V2 REGION FROM HIV - 1 STRAIN ZM109 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; FRAGMENT: V1V2 REGION; ENGINEERED: YES ? ? HOMO SAPIENS 14 QGTSNDVGGYESVS 7 DVSKRPS 10 KSLTSTRRRV 5 RQGMH 19 FIKYDGSEKYHADSVWGRL 26 EAGGPDYRNGYNDFYDGYYNYHYMDV crystal 1.80A 17.90% FAB 04-OCT-11 20111004 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A LINEAR - SPECIFIC UBIQUITIN FAB BOUND TO LINEAR UBIQUITIN MOLECULE: LINEAR DI - UBIQUITIN; SYNONYM: UBIQUITIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SAKFLYS 9 QQSYTTPPT 5 NTYIS 17 SITPSSGQTDYADSVKG 10 TWLLRWVMDL crystal 2.43A 23.10% FAB 04-OCT-11 20111004 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PG9 FAB ? ? ? HOMO SAPIENS 14 QGTSNDVGGYESVS 7 DVSKRPS 10 KSLTSTRRRV 5 RQGMH 19 FIKYDGSEKYHADSVWGRL 15 EAGGPDYYNYHYMDV crystal 3.28A 21.60% FAB 04-OCT-11 20111004 IMMUNE SYSTEM CH04H / CH02L P212121 ? ? ? HOMO SAPIENS 12 RASQNVHPRYFA 7 SGSTRAA 9 QQYGGSPYT 5 NFGFG 17 GTNWNGGDSRYGDSVKG 24 GTDYTIDDQGIRYQGSGTFWYFDV crystal 2.91A 21.60% FAB 07-OCT-11 20111007 IMMUNE SYSTEM CH04H / CH02L FAB P4 MOLECULE: CH04 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQNVHPRYFA 7 SGSTRAA 9 QQYGGSPYT 5 NFGFG 17 GTNWNGGDSRYGDSVKG 24 GTDYTIDDQGIRYQGSGTFWYFDV crystal 2.89A 22.40% FAB 07-OCT-11 20111007 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PG9 FAB IN COMPLEX WITH V1V2 REGION FROM HIV - 1 STRAIN CAP45 MOLECULE: V1V2 REGION OF HIV - 1 ON 1FD6 SCAFFOLD; ENGINEERED: YES; ? ? HOMO SAPIENS 14 QGTSNDVGGYESVS 7 DVSKRPS 10 KSLTSTRRRV 5 RQGMH 19 FIKYDGSEKYHADSVWGRL 26 EAGGPDYRNGYNDFYDGYYNYHYMDV crystal 2.19A 18.40% FAB 07-OCT-11 20111007 IMMUNE SYSTEM THREE DIMENSIONAL STRUCTURE OF BROADLY NEUTRALIZING ANTI - HEPATITIS C VIRUS (HCV) GLYCOPROTEIN E2 SINGLE CHAIN FV FRAGMENT 1:7 ? ? ? HOMO SAPIENS 11 RASQSVNKYLA 7 DASNRAT 8 QQRSDWVT 6 SRYTIQ 17 GNIIPVYNTPNYAQKFQ 18 RVVIPNAIRHTMGYYFDY crystal 2.67A 19.30% FV 12-OCT-11 20111012 IMMUNE SYSTEM AL - 103 Y32F Y96F ? ? ? HOMO SAPIENS 11 TCQASQDISNF 7 IYDASNL 12 YCQQYHNLPPFT 0 N/A 0 N/A 0 N/A crystal 1.62A 16.90% LC-dimer 13-OCT-11 20111013 IMMUNE SYSTEM AL - 09 Y32F Y96F ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 11 QASQDINNFLI 7 DASTLET 9 QQYDNLPFT 0 N/A 0 N/A 0 N/A crystal 2.00A 20.30% LC-dimer 13-OCT-11 20111013 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NIH45 - 46 FAB MOLECULE: HEAVY CHAIN, IG GAMMA - 1 CHAIN C REGION; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 9 RTSQSGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WLKPRGGAVNYARKFQG 16 GKYCTARDYYNWDFEH crystal 2.60A 18.70% FAB 14-OCT-11 20111014 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF NIH45 - 46 FAB IN COMPLEX WITH GP120 OF 93TH057 HIV MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP120 CORE (UNP RESIDUES 43 - 122, 201 - 303, 325 - 486); ENGINEERED: YES; MUTATION: YES; KAPPA ? HOMO SAPIENS 9 RTSQSGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WLKPRGGAVNYARKFQG 16 GKYCTARDYYNWDFEH crystal 2.45A 20.90% FAB 14-OCT-11 20111014 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MURINE SIDEROCALIN IN COMPLEX WITH AN FAB FRAGMENT MOLECULE: NEUTROPHIL GELATINASE - ASSOCIATED LIPOCALIN; SYNONYM: NGAL, LIPOCALIN - 2, SV - 40 - INDUCED 24P3 PROTEIN, P25; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 11 QASQIIYNYIA 7 YTSTLES 9 LQYDNLPYM 5 SNSVH 16 GIWGDGRTDYNSALKS 11 CRRDSSYVVDA crystal 2.80A 22.30% FAB 19-OCT-11 20111019 TRANSFERASE CRYSTAL STRUCTURE OF EXTRACELLULAR DOMAIN OF HUMAN ERBB4 / HER4 IN COMPLEX WITH THE FAB FRAGMENT OF MAB1479 MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 4; FRAGMENT: EXTRACELLULAR REGION 1 - 625, JM - A ISOFORM; SYNONYM: PROTO - ONCOGENE - LIKE PROTEIN C - ERBB - 4, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER4, P180ERBB4, ERBB4 INTRACELLULAR DOMAIN, 4ICD, E4ICD, S80HER4; EC: 2.7.10.1; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPWT 7 TYGIGVG 16 HIWWNDNKYYNIALRS 9 IPDDHYFDY crystal 3.42A 23.60% FAB 19-OCT-11 20111019 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ENVELOPE GLYCOPROTEIN ECTODOMAIN FROM DENGUE VIRUS SEROTYPE 4 IN COMPLEX WITH THE FAB FRAGMENT OF THE CHIMPANZEE MONOCLONAL ANTIBODY 5H2 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: UNP RESIDUES 280 - 674; ENGINEERED: YES; ? ? PAN TROGLODYTES 11 RASQDISIRLN 7 DASTLES 9 QQFNSYPLT 5 DFYWS 16 YAHSRVSAYYNPSLKS 15 QGTGTTGVSEDSFDL crystal 3.23A 24.10% FAB 21-OCT-11 20111021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MOUSE CD1D - C20:2 - AGALCER - L363 MAB FAB COMPLEX MOLECULE: BETA - 2 - MICROGLOBULIN; FRAGMENT: UNP RESIDUES 21 - 119; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASEDIYNRIA 7 GATSLET 9 QHYWSSPLT 5 NYGMH 17 WINTYTGEPTYADDFKG 11 AAGIRWAWFAW crystal 3.10A 20.30% FAB 25-OCT-11 20111025 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DOMAIN I OF THE ENVELOPE GLYCOPROTEIN ECTODOMAIN FROM DENGUE VIRUS SEROTYPE 4 IN COMPLEX WITH THE FAB FRAGMENT OF THE CHIMPANZEE MONOCLONAL ANTIBODY 5H2 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: SEE REMARK 999; ENGINEERED: YES; ? ? PAN TROGLODYTES 11 RASQDISIRLN 7 DASTLES 9 QQFNSYPLT 5 DFYWS 16 YAHSRVSAYYNPSLKS 15 QGTGTTGVSEDSFDL crystal 2.71A 22.20% FAB 25-OCT-11 20111025 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 2558 IN COMPLEX WITH MN PEPTIDE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 306 - 328; SYNONYM: ENV POLYPROTEIN, SURFACE PROTEIN GP120, SU, GLYCOPROTEIN 120, GP120, TRANSMEMBRANE PROTEIN GP41, TM, GLYCOPROTEIN 41, GP41; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDILGDKYVS 7 EDTKRPS 10 QAWDSTLGVV 5 NYWIA 17 IVYPDDSDSSYNSSFQG 14 LGFEGDYSGSFFDY crystal 1.60A 16.30% FAB 07-NOV-11 20111107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 4025 IN COMPLEX WITH CON A PEPTIDE MOLECULE: GP120; FRAGMENT: UNP RESIDUES 30 - 52; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDALPEKYAY 7 EDSKRPS 11 YSTNSGGTFFV 5 SYWIA 17 FIYPADSDTRYSPSFQG 15 LGFWGANRGGGGMDV crystal 2.00A 17.80% FAB 07-NOV-11 20111107 IMMUNE SYSTEM STRUCTURE OF THE FAB FRAGMENT OF AB - 52, AN ANTIBODY THAT BINDS THE O - ANTIGEN OF FRANCISELLA TULARENSIS ? ? ? MUS MUSCULUS 17 KSSQSLLNSSNQKNYLA 7 FASTRES 9 QQHYSTPFT 5 SSWMH 17 EIHPNSGNTNYNEKFKG 4 GFAY crystal 2.10A 18.70% FAB 08-NOV-11 20111108 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB12 ? ? ? HOMO SAPIENS 11 SGDNIGSYYVH 7 EDSERPS 10 SSYDDPNFQV 7 SNSAAWG 18 IIQKRSKWYNNYAVSVKS 10 YSYPFYSIDY crystal 2.50A 21.50% FAB 11-NOV-11 20111111 IMMUNE SYSTEM STRUCTURE OF QUATERNARY COMPLEX OF HUMAN TLR3ECD WITH THREE FABS (FORM1) MOLECULE: TOLL - LIKE RECEPTOR 3; FRAGMENT: UNP RESIDUES 22 - 702; SYNONYM: TLR3ECD; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNIGSYYVH 7 EDSERPS 10 SSYDDPNFQV 7 SNSAAWG 18 IIQKRSKWYNNYAVSVKS 10 YSYPFYSIDY crystal 3.52A 27.00% FAB 11-NOV-11 20111111 IMMUNE SYSTEM STRUCTURE OF QUATERNARY COMPLEX OF HUMAN TLR3ECD WITH THREE FABS (FORM2) MOLECULE: TOLL - LIKE RECEPTOR 3; FRAGMENT: UNP RESIDUES 22 - 702; SYNONYM: TLR3ECD; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNIGSYYVH 7 EDSERPS 10 SSYDDPNFQV 7 SNSAAWG 18 IIQKRSKWYNNYAVSVKS 10 YSYPFYSIDY crystal 3.52A 23.20% FAB 11-NOV-11 20111111 IMMUNE SYSTEM SCFV12, ANTI - BCLA ANTIBODY SINGLE CHAIN VARIABLE FRAGMENT ? ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.80A 17.70% scFv 14-NOV-11 20111114 IMMUNE SYSTEM STRUCTURE OF A MONOCLONAL ANTIBODY COMPLEXED WITH ITS MHC - I ANTIGEN MOLECULE: H - 2 CLASS I HISTOCOMPATIBILITY ANTIGEN, L - D ALPHA CHAIN; FRAGMENT: H - 2L (D) PEPTIDE SEGMENT 46 - 54; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 8 SQSTHVPT 5 DYYMA 17 NINYDGSSTYYLDSLKG 8 LTNGYLDV crystal 1.64A 18.60% ? 16-NOV-11 20111116 IMMUNE SYSTEM A GENERAL STRATEGY FOR THE GENERATION OF HUMAN ANTIBODY VARIABLE DOMAINS WITH INCREASED AGGREGATION RESISTANCE MOLECULE: KAPPA LIGHT CHAIN VARIABLE DOMAIN; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 RASQSISSYLN 7 DADDLQS 9 QQSYSTPNT 0 N/A 0 N/A 0 N/A crystal 1.80A 23.10% LC-dimer 17-NOV-11 20111117 IMMUNE SYSTEM A GENERAL STRATEGY FOR THE GENERATION OF HUMAN ANTIBODY VARIABLE DOMAINS WITH INCREASED AGGREGATION RESISTANCE MOLECULE: HEAVY CHAIN VARIABLE DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 DEDMS 17 AISGSGGSTYYADSVKG 7 SYGAFDY crystal 2.80A 21.10% HC-dimer 17-NOV-11 20111117 IMMUNE SYSTEM ENDOGENOUS - LIKE INHIBITORY ANTIBODIES TARGETING ACTIVATED METALLOPROTEINASE MOTIFS SHOW THERAPEUTIC POTENTIAL MOLECULE: METALLOPROTEINASE, LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 13 RSSQSINGNTFLE 7 KVSNRFS 9 FQASHVPPT 5 TYDMS 17 TISSGGSYTYYPDSVKG 10 FRYDGWYFDV crystal 2.18A 23.10% FAB 27-NOV-11 20111127 CYTOKINE / IMMUNE SYSTEM STRUCTURAL INSIGHTS INTO A HUMAN ANTI - IFN ANTIBODY EXERTING THERAPEUTIC POTENTIAL FOR SYSTEMIC LUPUS ERYTHEMATOSUS MOLECULE: INTERFERON ALPHA - 1 / 13; SYNONYM: INTERFERON 1B, IFN - ALPHA - 1 / 13, INTERFERON ALPHA - D, LEIF D; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNYVS 7 DNNQRPS 11 QVRDNNENEWV 7 IGSNYVS 13 LLIYDNNQRPSGV 26 RDNNENEWVFGGGTKLTVLEVQLVES crystal 2.80A 18.60% scFv 04-DEC-11 20111204 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE DENGUE VIRUS SEROTYPE 4 ENVELOPE PROTEIN DOMAIN III IN COMPLEX WITH THE VARIABLE DOMAINS OF MAB 4E11 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III (UNP RESIDUES 296 - 400); ENGINEERED: YES ? ? MUS MUSCULUS 17 TASGFNIKDTYMSWVKQ 7 NGDTKYD 15 YYCSRGWEGFAYWGQ 5 DTYMS 17 RIDPANGDTKYDPKFQG 26 GWEGFAYWGQGTLVTVSAVMTQTPAS crystal 2.00A 18.20% scFv 06-DEC-11 20111206 IMMUNE SYSTEM STRUCTURE OF A MONOCLONAL ANTIBODY COMPLEXED WITH ITS MHC - I ANTIGEN MOLECULE: H - 2 CLASS I HISTOCOMPATIBILITY ANTIGEN, L - D ALPHA CHAIN; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 8 SQSTHVPT 5 DYYMA 17 NINYDGSSTYYLDSLKG 8 LTNGYLDV crystal 1.70A 19.40% FAB 06-DEC-11 20111206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE DENGUE VIRUS SEROTYPE 3 ENVELOPE PROTEIN DOMAIN III IN COMPLEX WITH THE VARIABLE DOMAINS OF MAB 4E11 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III (UNP RESIDUES 293 - 393); ENGINEERED: YES ? ? MUS MUSCULUS 17 TASGFNIKDTYMSWVKQ 7 NGDTKYD 15 YYCSRGWEGFAYWGQ 5 DTYMS 17 RIDPANGDTKYDPKFQG 26 GWEGFAYWGQGTLVTVSALVMTQTPA crystal 2.04A 21.80% scFv 07-DEC-11 20111207 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE DENGUE VIRUS SEROTYPE 1 ENVELOPE PROTEIN DOMAIN III IN COMPLEX WITH THE VARIABLE DOMAINS OF MAB 4E11 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III (UNP RESIDUES 576 - 680); ENGINEERED: YES ? ? MUS MUSCULUS 17 TASGFNIKDTYMSWVKQ 7 NGDTKYD 15 YYCSRGWEGFAYWGQ 5 DTYMS 17 RIDPANGDTKYDPKFQG 26 GWEGFAYWGQGTLVTVSAGGGGSGGL crystal 1.60A 17.70% scFv 07-DEC-11 20111207 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE DENGUE VIRUS SEROTYPE 2 ENVELOPE PROTEIN DOMAIN III IN COMPLEX WITH THE VARIABLE DOMAINS OF MAB 4E11 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III (UNP RESIDUES 576 - 680); ENGINEERED: YES; ? ? MUS MUSCULUS 17 TASGFNIKDTYMSWVKQ 7 NGDTKYD 15 YYCSRGWEGFAYWGQ 5 DTYMS 17 RIDPANGDTKYDPKFQG 26 GWEGFAYWGQGTLVTVSASELVMTQT crystal 2.10A 20.60% scFv 07-DEC-11 20111207 TOXIN 2.7 ANGSTROM CRYSTAL STRUCTURE OF BONT / AI IN COMPLEX WITH NTNHA MOLECULE: NTNH; SYNONYM: TYPE A PROGENITOR TOXIN NONTOXIC - NONHA; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 GSRYM 16 SSIEPSGTAWDGDSAK 13 TGYRTDTRIPGGS crystal 2.70A 17.80% HC-dimer 07-DEC-11 20111207 IMMUNE SYSTEM FAB WN1 222 - 5 UNLIGANDED ? ? ? MUS MUSCULUS 11 RASQNINIWLS 7 KASNLHT 9 LQGQSYPRT 5 DYYMT 19 LIRNKRNGDTAEYSASVKG 9 QGRGYTLDY crystal 2.13A 24.00% FAB 08-DEC-11 20111208 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB WN1 222 - 5 IN COMPLEX WITH LPS WITH LPS ? ? MUS MUSCULUS 11 RASQNINIWLS 7 KASNLHT 9 LQGQSYPRT 5 DYYMT 19 LIRNKRNGDTAEYSASVKG 9 QGRGYTLDY crystal 1.73A 18.40% FAB 08-DEC-11 20111208 CELL ADHESION CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT - 1 MOLECULE: INTEGRIN BETA - 7; FRAGMENT: UNP RESIDUES 20 - 512; SYNONYM: GUT HOMING RECEPTOR BETA SUBUNIT; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLAKSYGNTYLS 7 GISNRFS 9 LQGTHQPYT 7 FTSYWMH 17 EIDPSESNTNYNQKFKG 12 GGYDGWDYAIDY crystal 3.15A 22.00% FAB 15-DEC-11 20111215 IMMUNE SYSTEM STRUCTURE OF A MONOCLONAL ANTIBODY COMPLEXED WITH ITS MHC - I ANTIGEN MOLECULE: H - 2 CLASS I HISTOCOMPATIBILITY ANTIGEN, L - D ALPHA CHAIN; FRAGMENT: H - 2L (D) PEPTIDE SEGMENT 46 - 54; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 8 SQSTHVPT 5 DYYMA 17 NINYDGSSTYYLDSLKG 8 LTNGYLDV crystal 1.64A 21.50% ? 15-DEC-11 20111215 CELL ADHESION CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT - 1 AND RO0505376 MOLECULE: INTEGRIN BETA - 7; FRAGMENT: UNP RESIDUES 20 - 512; SYNONYM: GUT HOMING RECEPTOR BETA SUBUNIT; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLAKSYGNTYLS 7 GISNRFS 9 LQGTHQPYT 7 FTSYWMH 17 EIDPSESNTNYNQKFKG 12 GGYDGWDYAIDY crystal 3.10A 19.80% FAB 15-DEC-11 20111215 IMMUNE SYSTEM STRUCTURE OF A MONOCLONAL ANTIBODY COMPLEXED WITH ITS MHC - I ANTIGEN MOLECULE: H - 2 CLASS I HISTOCOMPATIBILITY ANTIGEN, L - D ALPHA CHAIN; FRAGMENT: H - 2LD PEPTIDE P46 - 53; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 8 SQSTHVPT 5 DYYMA 17 NINYDGSSTYYLDSLKG 8 LTNGYLDV crystal 1.70A 19.80% ? 15-DEC-11 20111215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI - HBV E - ANTIGEN MONOCLONAL FAB FRAGMENT (E6) , UNBOUND ? ? ? MUS MUSCULUS 17 KSSQSVLYSSNQKNYLA 7 WASTRES 10 HQYLSSYMYT 5 SYGMS 17 TISSGGNYIYYPDTVKG 14 EGAYSGSSSYPMDY crystal 2.52A 18.10% FAB 19-DEC-11 20111219 IMMUNE SYSTEM LEPTIN RECEPTOR - ANTIBODY COMPLEX MOLECULE: LEPTIN RECEPTOR; FRAGMENT: LEPTIN BINDING DOMAIN OF HUMAN OBESITY RECEPTOR; SYNONYM: LEP - R, HUB219, OB RECEPTOR, OB - R; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KATQNVRTAVT 7 LASNRHT 9 LQHWNYPLT 5 DDGVS 16 VIWGGGSTYFNSLFKS 9 HDGHETMDY crystal 1.95A 17.30% FAB 20-DEC-11 20111220 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HEPATITIS B VIRUS E - ANTIGEN MOLECULE: E - ANTIGEN; FRAGMENT: HBV E - ANTIGEN (CP ( - 10) 149); ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSVLYSSNQKNYLA 7 WASTRES 10 HQYLSSYMYT 5 SYGMS 17 TISSGGNYIYYPDTVKG 14 EGAYSGSSSYPMDY crystal 3.34A 23.40% FAB 20-DEC-11 20111220 IMMUNE SYSTEM STRUCTURAL BASIS FOR BROAD DETECTION OF GENOGROUP II NOROVIRUSES BY A MONOCLONAL ANTIBODY THAT BINDS TO A SITE OCCLUDED IN THE VIRAL PARTICLE MOLECULE: CAPSID; FRAGMENT: P DOMAIN RESIDUES 224 - 538; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 RASENIYSYLA 7 NVKTLAE 10 QHHYGSPPWT 5 NYLIE 17 VINPRSGDTNSNEKFKG 11 SGTTAYFAMDY crystal 3.30A 23.00% FAB 20-DEC-11 20111220 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL HUMAN ANTI - RHESUS D FC IGG1 T125 (YB2 / 0) IN THE PRESENCE OF ZN2+ ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: RATTUS NORVEGICUS; EXPRESSION_SYSTEM_COMMON: RAT; EXPRESSION_SYSTEM_TAXID: 10116; EXPRESSION_SYSTEM_CELL_LINE: (ATCC, CRL-1662) [T125(YB2/0)]; EXPRESSION_SYSTEM_VECTOR_TYPE: CMV PROMOTER; EXPRESSION_SYSTEM_PLASMID: PCI-NEO 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.02A 23.70% FC 21-DEC-11 20111221 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL HUMAN ANTI - RHESUS D FC IGG1 T125 (YB2 / 0) DOUBLE MUTANT (H310 AND H435 IN K) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: HUMAN, IGHG1; EXPRESSION_SYSTEM: RATTUS NORVEGICUS; EXPRESSION_SYSTEM_COMMON: RAT; EXPRESSION_SYSTEM_TAXID: 10116; EXPRESSION_SYSTEM_CELL_LINE: EBV-TRANSFECTED B CELL CRL-1662; EXPRESSION_SYSTEM_VECTOR_TYPE: CMV PROMOTER; EXPRESSION_SYSTEM_PLASMID: PCI-NEO 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.77A 25.80% FC 22-DEC-11 20111222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL HUMAN ANTI - RHESUS D FC AND IGG1 T125 (YB2 / 0) IN THE PRESENCE OF EDTA ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: RATTUS NORVEGICUS; EXPRESSION_SYSTEM_COMMON: RAT; EXPRESSION_SYSTEM_TAXID: 10116; EXPRESSION_SYSTEM_CELL_LINE: (ATCC, CRL-1662) [T125(YB2/0)]; EXPRESSION_SYSTEM_VECTOR_TYPE: CMV PROMOTER; EXPRESSION_SYSTEM_PLASMID: PCI-NEO 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 25.50% FC 23-DEC-11 20111223 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF SUDAN EBOLAVIRUS GLYCOPROTEIN (STRAIN BONIFACE) BOUND TO 16F6 MOLECULE: ENVELOPE GLYCOPROTEIN; FRAGMENT: SUDAN BONIFACE GLYCOPROTEIN; SYNONYM: GP1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVTTAVA 7 WASTRHT 9 QQHYSTPLT 5 YYDMF 17 YINSGGGNTYYPDTVKG 10 QLYGNSFFDY crystal 3.35A 22.50% ? 06-JAN-12 20120106 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY 3F8 FAB FRAGMENT THAT BINDS TO GD2 GANGLIOSIDE MOLECULE: 3F8 LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQSVSNDVT 7 SASNRYS 6 QQDYSS 5 NYGVH 16 VIWAGGITNYNSAFMS 11 RGGHYGYALDY crystal 1.65A 17.80% FAB 09-JAN-12 20120109 IMMUNE SYSTEM ANTIBODY FAB FRAGMENT ? ? ? MUS MUSCULUS 11 KATQNVRTAVT 7 LASNRHT 9 LQHWNYPLT 5 DDGVS 16 VIWGGGSTYFNSLFKS 9 HDGHETMDY crystal 2.27A 19.40% FAB 10-JAN-12 20120110 SIGNALING PROTEIN CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE - AGONIST ANTIBODY AT 2.7 A RESOLUTION MOLECULE: ADENOSINE RECEPTOR A2A; FRAGMENT: UNP RESIDUES 1 - 316; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASEFIYSSLT 7 AATNLAD 9 QHFYGSTWA 5 AYNMN 17 NINPYYGSTRYNQKFKG 15 EGNYYDGGSVRYFDY crystal 2.70A 20.80% FAB 04-AUG-11 20110804 SIGNALING PROTEIN CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE - AGONIST ANTIBODY AT 3.1 A RESOLUTION MOLECULE: ADENOSINE RECEPTOR A2A; FRAGMENT: UNP RESIDUES 1 - 316; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASEFIYSSLT 7 AATNLAD 9 QHFYGSTWA 5 AYNMN 17 NINPYYGSTRYNQKFKG 15 EGNYYDGGSVRYFDY crystal 3.10A 19.90% FAB 04-AUG-11 20110804 CELL ADHESION / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN HEADPIECE (LIGAND - FREE FORM) MOLECULE: INTEGRIN BETA - 1; FRAGMENT: UNP RESIDUES 21 - 465; SYNONYM: FIBRONECTIN RECEPTOR SUBUNIT BETA, VLA - 4 SUBUNIT BETA; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSNKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 SYWIE 17 EILPGSGYIHYNEKFKG 9 ALALYAMDY crystal 2.90A 21.00% FAB 21-SEP-11 20110921 CELL ADHESION / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN HEADPIECE IN COMPLEX WITH RGD PEPTIDE MOLECULE: INTEGRIN BETA - 1; SYNONYM: FIBRONECTIN RECEPTOR SUBUNIT BETA, VLA - 4 SUBUNIT BETA; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSNKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 SYWIE 17 EILPGSGYIHYNEKFKG 9 ALALYAMDY crystal 2.90A 21.80% FAB 21-SEP-11 20110921 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF BMJ4 P24 CAPSID PROTEIN IN COMPLEX WITH A10F9 FAB MOLECULE: GAG PROTEIN; FRAGMENT: UNP RESIDUES 130 - 360; SYNONYM: P24 CAPSID PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 QHFWSTPRT 5 SYTMS 17 IISSGGSYTYYSDSVKG 13 DEGNGNYVEAMDY crystal 3.20A 21.50% FAB 12-APR-12 20120412 IMMUNE SYSTEM / DNA ANTIBODY 64M - 5 FAB IN COMPLEX WITH A DOUBLE - STRANDED DNA (6 - 4) PHOTOPRODUCT MOLECULE: DNA (5' - D ( *CP *CP *CP *GP *TP *CP *CP *AP *TP *AP *AP *TP *CP *AP *CP *TP *CP *G) - 3'); ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQNIVHSNGYTYLE 7 TVSNRFS 8 FRGSHVPT 5 NYWMH 17 TIYPGNSDTTYSQKFKG 11 RNYGSSYAMDY crystal 2.50A 24.70% FAB 30-JUL-12 20120730 HORMONE / HORMONE RECEPTOR / IMMUNE SYSTEM INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1 - CR IN COMPLEX WITH HUMAN INSULIN, ALPHA - CT PEPTIDE (704 - 719) AND FAB 83 - 7 MOLECULE: INSULIN B CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNFLA 7 WASTRES 8 QQYFRYRT 5 AYGVN 16 MIWGDGNTDYNSALKS 10 DPYGSKPMDY crystal 3.90A 26.60% FAB 06-NOV-12 20121106 HORMONE RECEPTOR / HORMONE / IMMUNE SYSTEM INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1 - CR IN COMPLEX WITH HIGH - AFFINITY INSULIN ANALOGUE [D - PRO - B26] - DTI - NH2, ALPHA - CT PEPTIDE (704 - 719) AND FAB 83 - 7 MOLECULE: INSULIN B CHAIN; FRAGMENT: UNP RESIDUES 25 - 50; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNFLA 7 WASTRES 8 QQYFRYRT 5 AYGVN 16 MIWGDGNTDYNSALKS 10 DPYGSKPMDY crystal 4.30A 29.10% FAB 06-NOV-12 20121106 HORMONE RECEPTOR / HORMONE / IMMUNE SYSTEM INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1 - CR IN COMPLEX WITH HIGH - AFFINITY INSULIN ANALOGUE [D - PRO - B26] - DTI - NH2, ALPHACT PEPTIDE (693 - 719) AND FAB 83 - 7 MOLECULE: INSULIN B CHAIN; FRAGMENT: UNP RESIDUES 25 - 50; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNFLA 7 WASTRES 8 QQYFRYRT 5 AYGVN 16 MIWGDGNTDYNSALKS 10 DPYGSKPMDY crystal 4.30A 29.10% FAB 06-NOV-12 20121106 HORMONE / HORMONE RECEPTOR / IMMUNE SYSTEM INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1,CR,L2, FNIII - 1 AND ALPHACT PEPTIDE IN COMPLEX WITH BOVINE INSULIN AND FAB 83 - 14 MOLECULE: INSULIN B CHAIN; ? ? MUS MUSCULUS 11 RASQDIGGNLY 7 ATSSLDP 9 LQYSSSPWT 5 NYDIH 17 WIYPGDGSTKYNEKFKG 4 EWAY crystal 4.40A 24.60% FAB 06-NOV-12 20121106 IMMUNE SYSTEM CRYSTAL STRUCTURE OF STAPHYLOCOCCAL EENTEROTOXIN B IN COMPLEX WITH A NOVEL NEUTRALIZATION MONOCLONAL ANTIBODY FAB FRAGMENT MOLECULE: ENTEROTOXIN TYPE B; SYNONYM: SEB; ENGINEERED: YES; ? ? MUS MUSCULUS 12 RATSSVSSTYLH 7 STSNLAS 9 QQYINYPLT 6 SDFAWN 16 YINYSGYTNYNPSLKS 12 EAYYGRAYWFAY crystal 3.10A 20.00% FAB 28-NOV-12 20121128 IMMUNE SYSTEM STRUCTURE OF HUMAN MONOCLONAL ANTIBODY E317 FAB ? ? ? HOMO SAPIENS 12 RASQSVTSSQLA 7 GASNRAT 8 QQYGSSPT 5 TYGVS 17 RTIPLFGKTDYAQKFQG 13 DLTTLTSYNWWDL crystal 2.32A 19.40% FAB 03-APR-13 20130403 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF HUMAN MONOCLONAL ANTIBODY E317 FAB COMPLEX WITH HSV - 2 GD MOLECULE: ENVELOPE GLYCOPROTEIN D; FRAGMENT: UNP RESIDUES 1 - 300; SYNONYM: GD; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVTSSQLA 7 GASNRAT 8 QQYGSSPT 5 TYGVS 17 RTIPLFGKTDYAQKFQG 13 DLTTLTSYNWWDL crystal 2.30A 20.60% FAB 03-APR-13 20130403 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI-POLYSIALIC ACID ANTIBODY SINGLE CHAI FRAGMENT (MAB735) COMPLEXED WITH OCTASIALIC ACID OCTASIALIC ACID ? ? MUS MUSCULUS 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.80A 23.40% scFv 14-MAY-13 20130514 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TNFALPHA IN COMPLEX WITH ADALIMUMAB FAB FRAGMENT MOLECULE: TUMOR NECROSIS FACTOR; FRAGMENT: TUMOR NECROSIS FACTOR, SOLUBLE FORM; SYNONYM: TNFALPHA; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGIRNYLA 7 AASTLQS 9 QRYNRAPYT 5 DYAMH 17 AITWNSGHIDYADSVEG 12 VSYLSTASSLDY crystal 3.10A 19.10% FAB 06-JUN-13 20130606 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - PROSTAGLANDIN E2 FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 LQGSHVPLT 5 EYFIH 17 WFYPGSGSLNYNGKFKD 8 HAYDKEPY crystal 2.02A 18.90% FAB 01-JUL-13 20130701 IMMUNE SYSTEM / OXIDOREDUCTASE REDUCED CYTOCHROME C - DEPENDENT NITRIC OXIDE REDUCTASE (CNOR) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ANTIBODY FRAGMENT MOLECULE: NITRIC OXIDE REDUCTASE SUBUNIT B; SYNONYM: NOR LARGE SUBUNIT, NITRIC OXIDE REDUCTASE CYTOCHROME B SUBUNIT; EC: 1.7.2.5; ? ? MUS MUSCULUS 11 RASKSIRKYLA 7 SGSTLQF 9 QQHNEYPLT 5 SYWMH 17 AVYPGNSDTSYNQKFKG 15 SSLDGYYVKNWCFDV crystal 2.70A 20.50% FAB 18-JUL-13 20130718 IMMUNE SYSTEM / OXIDOREDUCTASE REDUCED AND CARBONMONOXIDE - BOUND CYTOCHROME C - DEPENDENT NITRIC OXIDE REDUCTASE (CNOR) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ANTIBODY FRAGMENT MOLECULE: NITRIC OXIDE REDUCTASE SUBUNIT B; SYNONYM: NOR LARGE SUBUNIT, NITRIC OXIDE REDUCTASE CYTOCHROME B SUBUNIT; EC: 1.7.2.5; ? ? MUS MUSCULUS 11 RASKSIRKYLA 7 SGSTLQF 9 QQHNEYPLT 5 SYWMH 17 AVYPGNSDTSYNQKFKG 15 SSLDGYYVKNWCFDV crystal 2.50A 19.30% FAB 18-JUL-13 20130718 IMMUNE SYSTEM / OXIDOREDUCTASE REDUCED AND ACETALDOXIME - BOUND CYTOCHROME C - DEPENDENT NITRIC OXIDE REDUCTASE (CNOR) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ANTIBODY FRAGMENT MOLECULE: NITRIC OXIDE REDUCTASE SUBUNIT B; SYNONYM: NOR LARGE SUBUNIT, NITRIC OXIDE REDUCTASE CYTOCHROME B SUBUNIT; EC: 1.7.2.5; ? ? MUS MUSCULUS 11 RASKSIRKYLA 7 SGSTLQF 9 QQHNEYPLT 5 SYWMH 17 AVYPGNSDTSYNQKFKG 15 SSLDGYYVKNWCFDV crystal 2.30A 19.30% FAB 18-JUL-13 20130718 IMMUNE SYSTEM / OXIDOREDUCTASE REDUCED AND CYANIDE - BOUND CYTOCHROME C - DEPENDENT NITRIC OXIDE REDUCTASE (CNOR) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ANTIBODY FRAGMENT MOLECULE: NITRIC OXIDE REDUCTASE SUBUNIT B; SYNONYM: NOR LARGE SUBUNIT, NITRIC OXIDE REDUCTASE CYTOCHROME B SUBUNIT; EC: 1.7.2.5; ? ? MUS MUSCULUS 11 RASKSIRKYLA 7 SGSTLQF 9 QQHNEYPLT 5 SYWMH 17 AVYPGNSDTSYNQKFKG 15 SSLDGYYVKNWCFDV crystal 2.49A 19.10% FAB 18-JUL-13 20130718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - PROSTAGLANDIN E2 FAB FRAGMENT PGE2 COMPLEX IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - PROSTAGLANDIN E2 FAB FRAGMENT PGE2 COMPLEX ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 LQGSHVPLT 5 EYFIH 17 WFYPGSGSLNYNGKFKD 8 HAYDKEPY crystal 1.90A 16.90% FAB 19-JUL-13 20130719 VIRAL PROTEIN / IMMUNE SYSTEM A NEW CONSERVED NEUTRALIZING EPITOPE AT THE GLOBULAR HEAD OF HEMAGGLUTININ IN H3N2 INFLUENZA VIRUSES MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 25 - 517; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGYAVH 7 GNSNRPS 11 QSYDSSLSGSV 5 SYGLS 17 WINTYDGQTKYVKKFQG 17 VEGVRGVMGFHYYPMDV crystal 4.00A 23.50% ? 25-AUG-13 20130825 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - PROSTAGLANDIN E2 FAB FRAGMENT PGE1 COMPLEX IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - PROSTAGLANDIN E2 FAB FRAGMENT PGE1 COMPLEX ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 LQGSHVPLT 5 EYFIH 17 WFYPGSGSLNYNGKFKD 8 HAYDKEPY crystal 1.70A 16.90% FAB 03-SEP-13 20130903 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - PROSTAGLANDIN E2 FAB FRAGMENT 9CL - PGF2BETA COMPLEX IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - PROSTAGLANDIN E2 FAB FRAGMENT 9CL - PGF2BETA COMPLEX ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 LQGSHVPLT 5 EYFIH 17 WFYPGSGSLNYNGKFKD 8 HAYDKEPY crystal 1.70A 17.30% FAB 12-SEP-13 20130912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE THIRD FIBRONECTIN DOMAIN (FN3) OF HUMAN ROBO1 IN COMPLEX WITH THE FAB FRAGMENT OF MURINE MONOCLONAL ANTIBODY B2212A. MOLECULE: ROUNDABOUT HOMOLOG 1; SYNONYM: DELETED IN U TWENTY TWENTY, H - ROBO - 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDISNFLN 7 YTSRLHS 9 QQGNTLPLT 5 DYYMN 17 DIVPNNGDTTYNQNFRG 10 FSNYVYPFDY crystal 1.70A 19.20% FAB 12-SEP-13 20130912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF B2212A, A MURINE MONOCLONAL ANTIBODY SPECIFIC FOR THE THIRD FIBRONECTIN DOMAIN (FN3) OF HUMAN ROBO1. ? ? ? MUS MUSCULUS 11 RASQDISNFLN 7 YTSRLHS 9 QQGNTLPLT 5 DYYMN 17 DIVPNNGDTTYNQNFRG 10 FSNYVYPFDY crystal 1.60A 18.70% FAB 12-SEP-13 20130912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IIB SELECTIVE FC VARIANT, FC (P238D) , IN COMPLEX WITH FCGRIIB ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK293F; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD32, FCG2, FCGR2B, FCGR2C, IGFR2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 23.20% FC 10-OCT-13 20131010 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IIB SELECTIVE FC VARIANT, FC (V12) , IN COMPLEX WITH FCGRIIB ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK293F; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR2C, CD32, FCG2, IGFR2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.86A 23.20% FC 11-OCT-13 20131011 HYDROLASE THE PERIPLASMIC PDZ TANDEM FRAGMENT OF THE RSEP HOMOLOGUE FROM AQUIFEX AEOLICUS IN COMPLEX WITH THE FAB FRAGMENT MOLECULE: PUTATIVE ZINC METALLOPROTEASE AQ_1964; FRAGMENT: PDZ TANDEM FRAGMENT, UNP RESIDUES 115 - 292; EC: 3.4.24. -; ENGINEERED: YES; KAPPA IGG1 MUS MUSCULUS 15 RASESVDSYGDSFMH 7 LASNLES 9 QQNNEDPWT 5 DTYLH 17 RIDPANGNAKYDPKFQD 14 RQLGLRGYYYAMDY crystal 2.20A 22.70% FAB 28-OCT-13 20131028 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ARTIFICIAL PROTEIN AFFINGER P17 (AF.P17) COMPLEXED WITH FC FRAGMENT OF HUMAN IGG ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL: OVARY CELL; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.90A 20.20% FC 29-OCT-13 20131029 HYDROLASE / IMMUNE SYSTEM MOLECULAR ARCHITECTURE OF THE ERBB2 EXTRACELLULAR DOMAIN HOMODIMER MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN, MLN 19, PROTO - ONCOGENE NEU, PROTO - ONCOGENE C - ERBB - 2, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2, P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 DVSKRPS 10 SSYTSSSTLV 5 SYWIG 17 WISAYNGNTNYAQKLQG 8 EGDGAFDY crystal 3.09A 23.40% ? 15-NOV-13 20131115 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ASYMMETRICALLY ENGINEERED FC VARIANT IN COMPLEX WITH FCGRIIIA ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A, CD16A, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.78A 23.80% FC 05-DEC-13 20131205 TRANSFERASE / IMMUNE SYSTEM STRUCTURE OF HER2 WITH AN FAB MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; FRAGMENT: UNP RESIDUES 23 - 586; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN, MLN 19, PROTO - ONCOGENE NEU, PROTO - ONCOGENE C - ERBB - 2, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2, P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSRTNAGRDPVS 7 TAPQGPS 11 TVWDSVPGASV 5 SYGIS 17 DVNTYAGNTNYAQKLQG 9 DRGYYAFDI crystal 3.50A 22.40% FAB 20-MAR-14 20140320 APOPTOSIS / IMMUNE SYSTEM TRAIL - R2 EXTRACELLULAR REGION COMPLEXED TO A FAB FRAGMENT FROM HUMAN AGONIST ANTIBODY KMTR2 MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; FRAGMENT: UNP RESIDUES 54 - 184; SYNONYM: DEATH RECEPTOR 5, TNF - RELATED APOPTOSIS - INDUCING LIGAND RECEPTOR 2, TRAIL RECEPTOR 2, TRAIL - R2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWPLT 5 NYKIN 17 WMNPDTDSTGYPQKFQG 17 SYGSGSYYRDYYYGMDV crystal 2.10A 18.80% FAB 20-JAN-15 20150120 IMMUNE SYSTEM FAB FRAGMENT FROM ANTI TRAIL - R2 HUMAN AGONIST ANTIBODY KMTR2 MOLECULE: HEAVY CHAIN OF KMTR2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWPLT 5 NYKIN 17 WMNPDTDSTGYPQKFQG 17 SYGSGSYYRDYYYGMDV crystal 2.51A 18.80% FAB 20-JAN-15 20150120 CELL ADHESION / IMMUNE SYSTEM INTEGRIN ALPHAIIB BETA3 HEADPIECE AND RGD PEPTIDE COMPLEX MOLECULE: INTEGRIN BETA - 3; FRAGMENT: INTEGRIN HEADPIECE, RESIDUES 27 - 498; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.45A 16.30% FAB 03-DEC-12 20121203 CELL ADHESION / IMMUNE SYSTEM / PEPTIDE INTEGRIN ALPHAIIB BETA3 HEADPIECE AND RGD PEPTIDE COMPLEX MOLECULE: INTEGRIN BETA - 3; FRAGMENT: RESIDUES 27 - 498; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.45A 18.23% FAB 03-DEC-12 20121203 CELL ADHESION / IMMUNE SYSTEM / PEPTIDE INTEGRIN ALPHAIIB BETA3 HEADPIECE AND RGD PEPTIDE COMPLEX MOLECULE: INTEGRIN BETA - 3; FRAGMENT: RESIDUES 27 - 498; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.75A 18.48% FAB 03-DEC-12 20121203 CELL ADHESION / IMMUNE SYSTEM / PEPTIDE INTEGRIN ALPHAIIB BETA3 HEADPIECE AND RGD PEPTIDE COMPLEX MOLECULE: INTEGRIN BETA - 3; FRAGMENT: RESIDUES 27 - 498; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.95A 18.54% FAB 03-DEC-12 20121203 CELL ADHESION / IMMUNE SYSTEM / PEPTIDE INTEGRIN ALPHAIIB BETA3 HEADPIECE AND RGD PEPTIDE COMPLEX MOLECULE: INTEGRIN BETA - 3; FRAGMENT: RESIDUES 27 - 498; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 3.00A 17.57% FAB 03-DEC-12 20121203 CELL ADHESION / IMMUNE SYSTEM / PEPTIDE INTEGRIN ALPHAIIB BETA3 HEADPIECE AND RGD PEPTIDE COMPLEX MOLECULE: INTEGRIN BETA - 3; FRAGMENT: RESIDUES 27 - 498; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.35A 17.55% FAB 03-DEC-12 20121203 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF SINGLE DOMAIN ANTIBODY 8 - 4 SCAFFOLD. HUMAN HEAVY CHAIN DOMAIN ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 SYAMG 17 LISGSGGSTWYDDSVKG 10 HAPSTEAPDY crystal 1.96A 18.06% HC-dimer 21-DEC-12 20121221 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF SINGLE DOMAIN ANTIBODY 2X1 SCAFFOLD ? ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 SYAMS 17 AISGSGGSTYYADSVKG 10 HAPSTEAPDY crystal 1.96A 25.52% HC-dimer 22-DEC-12 20121222 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF SINGLE DOMAIN ANTIBODY 8 - 14 SCAFFOLD ? ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 SYAMG 17 LISGSGGSTWYDDSVKG 10 HAPSTEAPDY crystal 2.47A 19.40% HC-dimer 22-DEC-12 20121222 HYDROLASE / IMMUNE SYSTEM BACE2 FAB COMPLEX MOLECULE: BETA - SECRETASE 2; FRAGMENT: EXTRACELLULAR, RESIDUES 75 - 460; SYNONYM: ASPARTIC - LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA - SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA - SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, M MEMAPSIN - 1, MEMBRANE - ASSOCIATED ASPARTIC PROTEASE 1, THETA - SECRETASE BACE2; EC: 3.4.23.45; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASKSVDTYGHSFIH 7 LASNLES 9 QQNNEDPWT 5 RYGVH 16 VIWAGGTTNYNSAFMS 8 AYRNAMDY crystal 1.85A 21.25% FAB 23-JAN-13 20130123 IMMUNE SYSTEM / HYDROLASE BACE2 FAB INHIBITOR COMPLEX MOLECULE: BETA - SECRETASE 2; FRAGMENT: EXTRACELLULAR DOMAN, RESIDUES 13 - 198; SYNONYM: BACE2, ASPARTIC - LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA - SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA - SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN - 1, MEMBRANE - ASSOCIATED ASPARTIC PROTEASE 1, THETA - SECRETASE; EC: 3.4.23.45; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASKSVDTYGHSFIH 7 LASNLES 9 QQNNEDPWT 5 RYGVH 16 VIWAGGTTNYNSAFMS 8 AYRNAMDY crystal 2.00A 20.56% FAB 23-JAN-13 20130123 HYDROLASE / IMMUNE SYSTEM BACE2 XAPERONE COMPLEX MOLECULE: BETA - SECRETASE 2; FRAGMENT: EXTRACELLULAR, RESIDUES 75 - 460; SYNONYM: ASPARTIC - LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA - SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA - SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN - 1, MEMBRANE - ASSOCIATED ASPARTIC PROTEASE 1, THETA - SECRETASE, BACE2; EC: 3.4.23.45; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SAIMT 17 TIGSDGSITTYADSVKG 16 AGRRGPGTQVTVSSHH crystal 1.51A 19.13% HC-dimer 24-JAN-13 20130124 HYDROLASE / IMMUNE SYSTEM BACE2 XAPERONE COMPLEX WITH INHIBITOR MOLECULE: BETA - SECRETASE 2; FRAGMENT: EXTRACELLULAR, RESIDUES 75 - 460; SYNONYM: ASPARTIC - LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA - SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA - SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN - 1, MEMBRANE - ASSOCIATED ASPARTIC PROTEASE 1, THETA - SECRETASE, BACE2; EC: 3.4.23.45; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SAIMT 17 TIGSDGSITTYADSVKG 3 AGR crystal 2.11A 21.12% HC-dimer 24-JAN-13 20130124 IMMUNE SYSTEM ANTIBODY STRUCTURAL ORGANIZATION: ROLE OF KAPPA - LAMBDA CHAIN CONSTANT DOMAIN SWITCH IN CATALYTIC FUNCTIONALITY ? KAPPA ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 10 GTWDSSLNPV 6 SGYYWG 16 SIYHSGSTYYNPSLKS 10 LTQSSHNDAN crystal 1.95A 20.77% FAB 28-JAN-13 20130128 IMMUNE SYSTEM / LIGASE MOUSE IGG2A IN COMPLEX WITH MOUSE TRIM21 PRYSPRY ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.99A 18.47% FV 19-FEB-13 20130219 IMMUNE SYSTEM / VIRAL PROTEIN STRUCTURE OF INFLUENZA A NEUTRALIZING ANTIBODY SELECTED FROM CULTURES OF SINGLE HUMAN PLASMA CELLS IN COMPLEX WITH HUMAN H3 INFLUENZA HAEMAGGLUTININ. MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: RESIDUES 346 - 520; ? ? HOMO SAPIENS 15 KSSQSVTFNYKNYLA 7 WASTRES 9 QQHYRTPPT 5 TYAMH 17 VISYDANYKYYADSVKG 20 DSQLRSLLYFEWLSQGYFDY crystal 3.41A 23.67% ? 08-JUL-11 20110708 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF INFLUENZA A NEUTRALIZING ANTIBODY SELECTED FROM CULTURES OF SINGLE HUMAN PLASMA CELLS IN COMPLEX WITH HUMAN H1 INFLUENZA HAEMAGGLUTININ. MOLECULE: HAEMAGGLUTININ; FRAGMENT: HA2, RESIDUES 345 - 520; ? ? HOMO SAPIENS 15 KSSQSVTFNYKNYLA 7 WASTRES 9 QQHYRTPPT 5 TYAMH 17 VISYDANYKYYADSVKG 20 DSQLRSLLYFEWLSQGYFDY crystal 3.00A 21.80% ? 12-JUL-11 20110712 IMMUNOGLOBULIN CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY ? ? ? MUS MUSCULUS 17 KSSQSLLNISNQKNYLA 7 FASTRES 9 QQHYRAPRT 6 SRYNVH 16 GMIWGGGSIEYNPALK 11 SYGYGGDRFSY crystal 2.20A 21.00% FV 10-MAR-99 19990310 IMMUNOGLOBULIN CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY WITH BOUND P - NITROPHENOL ? ? ? MUS MUSCULUS 17 KSSQSLLNISNQKNYLA 7 FASTRES 9 QQHYRAPRT 5 RYNVH 16 MIWGGGSIEYNPALKS 10 YGYGGDRFSY crystal 2.30A 20.60% FV 10-MAR-99 19990310 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - (4 - HYDROXY - 3 - NITROPHENYL) - ACETYL MURINE GERMLINE ANTIBODY BBE6.12H3 ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTAYNEKFKS 11 YDYYGGSYFDY crystal 2.90A 24.00% FAB 10-NOV-11 20111110 IMMUNE SYSTEM DEACTIVATION OF HUMAN IGG1 FC BY ENDOGLYCOSIDASE TREATMENT ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; CELL_LINE: 293T; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293T; EXPRESSION_SYSTEM_ATCC_NUMBER: CRL-1573; EXPRESSION_SYSTEM_PLASMID: PHLSEC 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.49A 19.68% FC 16-DEC-11 20111216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - AAHI FAB9C2 ANTIBODY ? ? ? MUS MUSCULUS 11 RASENIYRNLA 7 AATNLAA 9 QHFWNIPFT 5 SNWIN 17 NISPGGSNTNHNEKFKS 10 YDGDYGSFDY crystal 1.60A 17.61% FAB 10-JAN-12 20120110 IMMUNE SYSTEM / TOXIN CRYSTAL STRUCTURE OF THE AAHII - FAB4C1 COMPLEX MOLECULE: ALPHA - MAMMAL TOXIN AAH2; SYNONYM: AAH II, AAHII, NEUROTOXIN 2; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPLT 5 GYYMY 17 SISDGGSFTYYPDSVKG 11 PDDYSYDGFAY crystal 2.30A 20.14% FAB 10-JAN-12 20120110 IMMUNE SYSTEM / TRANSFERASE CRYSTAL STRUCTURE OF A DDR1 - FAB COMPLEX MOLECULE: EPITHELIAL DISCOIDIN DOMAIN - CONTAINING RECEPTOR 1; FRAGMENT: RESIDUES 29 - 367; SYNONYM: EPITHELIAL DISCOIDIN DOMAIN RECEPTOR 1, CD167 ANTIGEN - LIKE FAMILY MEMBER A, CELL ADHESION KINASE, DISCOIDIN RECEPTOR TYROSINE KINASE, HGK2, MAMMARY CARCINOMA KINASE 10, MCK - 10, PROTEIN - TYROSINE KINASE 3A, PROTEIN - TYROSINE KINASE RTK - 6, TRK E, TYROSINE KINASE DDR, TYROSINE - PROTEIN KINASE CAK, CD167A; EC: 2.7.10.1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVTFMY 7 LTSNLAS 9 QQWSSNPYT 5 ISWIN 17 NIYPSGGYTNYNQKFKD 7 GYGHLDY crystal 2.80A 21.56% FAB 24-JAN-12 20120124 IMMUNE SYSTEM STRUCTURE OF DENGUE VIRUS DIII IN COMPLEX WITH FAB 2H12 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III, RESIDUES 295 - 395; SYNONYM: E GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 KASQNVRTSVA 7 LASNRHT 9 LQHWTYPYT 5 SYWIN 17 NIYPGSGTVNYDDKFKS 8 GGSHAMDY crystal 1.66A 17.13% FAB 02-MAR-12 20120302 IMMUNE SYSTEM STRUCTURE OF DENGUE VIRUS DIII IN COMPLEX WITH FAB 2H12 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III, RESIDUES 293 - 393; SYNONYM: E GLYCOPROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQNVRTSVA 7 LASNRHT 9 LQHWTYPYT 5 SYWIN 17 NIYPGSGTVNYDDKFKS 8 GGSHAMDY crystal 1.84A 17.88% FAB 02-MAR-12 20120302 VIRAL PROTEIN STRUCTURE OF DENGUE VIRUS STRAIN 4 DIII IN COMPLEX WITH FAB 2H12 MOLECULE: ENVELOPE PROTEIN,; FRAGMENT: DOMAIN III, RESIDUES 295 - 395; SYNONYM: E GLYCOPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS, MUS MUSCULUS 11 KASQNVRTSVA 7 LASNRHT 9 LQHWTYPYT 5 SYWIN 17 NIYPGSGTVNYDDKFKS 8 GGSHAMDY crystal 3.02A 19.88% FAB 06-MAR-12 20120306 IMMUNE SYSTEM FAB FRAGMENT OF ANTIPORPHRIN ANTIBODY 13G10 ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 5 SYNMH 17 VIYPGNGDTSYSQKFKG 8 GGAGIMAY crystal 2.05A 22.44% FAB 12-MAR-12 20120312 STRUCTURAL PROTEIN STRUCTURE OF THE SBSB S - LAYER PROTEIN OF GEOBACILLUS STEAROTHERMOPHILUS PV72P2 IN COMPLEX WITH NANOBODY KB6 MOLECULE: SBSB PROTEIN; FRAGMENT: RESIDUES 32 - 920; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 AYAMG 17 GISSKGGSTYYGASMKG 15 SDKYNFDTSHAGYGY crystal 2.42A 18.57% HC-dimer 12-APR-12 20120412 IMMUNE SYSTEM FAB FRAGMENT OF ANTIPORPHYRIN ANTIBODY 14H7 ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHLV 0 17 VIYPGNGDTSYNQKFRD 8 GGSGLLAY crystal 2.55A 28.13% FAB 04-MAY-12 20120504 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN AMYLOID - BETA BINDING SINGLE CHAIN ANTIBODY G7 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NNAMG 16 RISSGGRTTYADSVKG 10 ASLVRGPLDH crystal 1.19A 13.74% HC-dimer 27-JUL-12 20120727 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 GP41 MPER - SPECIFIC LLAMA VHH 2H10 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 VDVMS 16 FITDRGRTNYKVSVKG 14 ESRTSWSSPSPLDV crystal 1.30A 14.68% HC-dimer 02-AUG-12 20120802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ISOLATED IGG4 CH3 DOMAIN ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.80A 18.51% FC 02-AUG-12 20120802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN AMYLOID - BETA BINDING SINGLE CHAIN ANTIBODY PS2 - 8 MOLECULE: PS2 - 8; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RDAMG 19 VAAINLNGGRTYSADSVKG 18 REGDVGLVSYKRSSNYPY crystal 1.94A 18.41% HC-dimer 03-AUG-12 20120803 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG FC BEARING HYBRID - TYPE GLYCANS ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293T; EXPRESSION_SYSTEM_ATCC_NUMBER: CRL-1573; EXPRESSION_SYSTEM_VECTOR: PHLSEC 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.36A 21.78% FC 20-AUG-12 20120820 IMMUNE SYSTEM HIGH RESOLUTION NMR STRUCTURE OF THE C MU3 DOMAIN FROM IGM ? ? IGM MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A NMR N/A N/A ? 12-SEP-12 20120912 HYDROLASE / IMMUNE SYSTEM BACE2 XAPERONE COMPLEX MOLECULE: BETA - SECRETASE 2; FRAGMENT: EXTRACELLULAR, RESIDUES 75 - 460; SYNONYM: ASPARTIC - LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA - SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA - SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN - 1, MEMBRANE - ASSOCIATED ASPARTIC PROTEASE 1, THETA - SECRETASE, BACE2; EC: 3.4.23.45; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SAIMT 17 TIGSDGSITTYADSVKG 3 AGR crystal 1.85A 18.34% HC-dimer 11-MAR-13 20130311 HYDROLASE / IMMUNE SYSTEM BACE2 XAPERONE COMPLEX MOLECULE: BETA - SECRETASE 2; FRAGMENT: EXTRACELLULAR, RESIDUES 75 - 460; SYNONYM: ASPARTIC - LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA - SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA - SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN - 1, MEMBRANE - ASSOCIATED ASPARTIC PROTEASE 1, THETA - SECRETASE, BACE2; EC: 3.4.23.45; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SAIMT 17 TIGSDGSITTYADSVKG 3 AGR crystal 2.21A 20.72% HC-dimer 18-MAR-13 20130318 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GERMLINE ANTIBODY 36 - 65 IN COMPLEX WITH PEPTIDE PPYPAWHAPGNI MOLECULE: DODECAPEPTIDE ANTIGEN; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YGSRLHS 9 QQGNTLPRT 5 SYGIN 17 YINPGNGYTKYNEKFKG 12 SVYYGGSYYFDY crystal 2.89A 22.99% ? 30-MAR-13 20130330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GERMLINE ANTIBODY 36 - 65 IN COMPLEX WITH PEPTIDE GDPRPSYISHLL MOLECULE: DODECAPEPTIDE ANTIGEN; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YGSRLHS 9 QQGNTLPRT 5 SYGIN 17 YINPGNGYTKYNEKFKG 12 SVYYGGSYYFDY crystal 2.40A 23.05% ? 30-MAR-13 20130330 IMMUNOGLOBULIN LOCW, A LAMBDA 1 TYPE LIGHT - CHAIN DIMER (BENCE - JONES PROTEIN) CRYSTALLIZED IN DISTILLED WATER MOLECULE: LOC - LAMBDA 1 TYPE LIGHT - CHAIN DIMER; SYNONYM: BENCE - JONES PROTEIN; OTHER_DETAILS: CRYSTALLIZED IN DISTILLED WATER LAMBDA ? HOMO SAPIENS 13 SGSSSNIGENSVT 7 EDNSRAS 11 AAWDDSLDVAV 0 N/A 0 N/A 0 N/A crystal 2.40A 15.50% LC-dimer 26-MAY-95 19950526 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ARTHRITOGENIC ANTIBODY M2139 (FAB FRAGMENT) IN COMPLEX WITH THE TRIPLE - HELICAL J1 PEPTIDE MOLECULE: J1 EPITOPE; OTHER_DETAILS: TRIPLE - HELICAL SYNTHETIC PEPTIDE, CHAINS CROSSLINKED AT C - TERMINUS, CONTAINS J1 - EPITOPE OF COLLAGEN TYPE II FROM MOUSE FLANKED BY GPO REPEATS; ? ? MUS MUSCULUS 15 RASESVEYFGTSLMQ 7 AASNVES 9 QQSREVPYT 5 SYWMN 17 AINPSDGYTEYNQKFKD 7 YGGYFDY crystal 3.25A 22.38% FAB 26-APR-13 20130426 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IGG FC F241A MUTANT WITH NATIVE GLYCOSYLATION ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293T; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: PHLSEC 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.95A 19.97% FC 07-MAY-13 20130507 IMMUNE SYSTEM HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 1 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.75A 17.93% FC 11-JUN-13 20130611 IMMUNE SYSTEM HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 2 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.15A 20.30% FC 11-JUN-13 20130611 IMMUNE SYSTEM HUMAN IGE AGAINST THE MAJOR ALLERGEN BET V 1 - CRYSTAL STRUCTURE OF CLONE M0418 SCFV ? ? IGE HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.30A 14.67% scFv 20-JUN-13 20130620 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SIALYLATED IGG FC ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_VARIANT: CRL-1573; EXPRESSION_SYSTEM_CELL_LINE: HEK 293T; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: PHLSEC 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 22.43% FC 19-JUL-13 20130719 IMMUNE SYSTEM / VIRAL PROTEIN STRUCTURE OF DENGUE VIRUS EDIII IN COMPLEX WITH FAB 3E31 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN 3, RESIDUES 301 - 394; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNHLA 7 WASTRES 9 QHFYIYPYT 5 SYWIN 17 DIYPGRGTTNYNENFKS 8 GSKGAMDY crystal 2.15A 22.50% FAB 23-JUL-13 20130723 IMMUNE SYSTEM - VIRAL PROTEIN COMPLEX STRUCTURE OF DENGUE VIRUS EDIII IN COMPLEX WITH FAB 2D73 MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN 3, RESIDUES 301 - 394; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQGINSDLS 7 RANRLVD 9 LQYDEFPLT 5 DYNMH 17 YTYPYNGGIGYNQKFKS 12 RGYRYDGAHFDY crystal 2.03A 20.62% FAB 23-JUL-13 20130723 VIRUS / IMMUNE SYSTEM CRYO - EM RECONSTRUCTION OF ENTEROVIRUS 71 IN COMPLEX WITH A NEUTRALIZING ANTIBODY E18 MOLECULE: VP2; ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 7 XXXXXXX 19 XXXXXXXXXXXXXXXXXXX 26 XXXXXXXXXXXXXXXXXXXXXXXXXX ElectronMicroscopy N/A N/A HC-dimer 08-AUG-13 20130808 VIRUS / IMMUNE SYSTEM CRYO - EM RECONSTRUCTION OF EMPTY ENTEROVIRUS 71 IN COMPLEX WITH A NEUTRALIZING ANTIBODY E18 MOLECULE: VP2; ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 7 XXXXXXX 19 XXXXXXXXXXXXXXXXXXX 26 XXXXXXXXXXXXXXXXXXXXXXXXXX ElectronMicroscopy N/A N/A HC-dimer 08-AUG-13 20130808 VIRUS / IMMUNE SYSTEM CRYO - EM RECONSTRUCTION OF EMPTY ENTEROVIRUS 71 IN COMPLEX WITH A NEUTRALIZING ANTIBODY E19 MOLECULE: VP3; ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 7 XXXXXXX 19 XXXXXXXXXXXXXXXXXXX 26 XXXXXXXXXXXXXXXXXXXXXXXXXX ElectronMicroscopy N/A N/A HC-dimer 08-AUG-13 20130808 VIRUS CRYO - EM STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH FAB FRAGMENTS OF HUMAN ANTIBODY 1F4 MOLECULE: POLYPROTEIN; FRAGMENT: MEMBRANE PROTEIN, RESIDUES 206 - 280; OTHER_DETAILS: STRAIN PVP159; ? ? HOMO SAPIENS 13 SGSSSNIGNNAVN 7 YDDLLPS 11 AAWDDSLIGVV 5 AYGMH 17 IIWYDGSNKYYADSVKG 16 DKNPGTKPYYHYGMDV ElectronMicroscopy N/A N/A FAB 18-AUG-13 20130818 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RECOMBINANT HUMAN IGG4 FC ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 17.20% FC 10-SEP-13 20130910 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SERUM - DERIVED HUMAN IGG4 FC ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.35A 19.03% FC 10-SEP-13 20130910 TRANSFERASE STRUCTURE OF GAK KINASE IN COMPLEX WITH A NANOBODY MOLECULE: CYCLIN - G - ASSOCIATED KINASE; FRAGMENT: KINASE DOMAIN RESIDUES 14 - 351; SYNONYM: GAK; EC: 2.7.11.1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DSYMS 17 GIWEDSSAAHYRDSVKG 26 RGYSGDYRPINNPSSQGTQVTVSSAA crystal 2.55A 18.02% HC-dimer 10-SEP-13 20130910 TRANSFERASE STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_VARIANT: R3; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PNIC28-BSA4; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844 0 0 0 0 0 0 crystal 2.16A 18.24% Nanobody 10-SEP-13 20130910 TRANSFERASE STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_VARIANT: R3; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PNIC28-BSA4; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844 0 0 0 0 0 0 crystal 2.80A 20.52% Nanobody 10-SEP-13 20130910 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE IGG2A LPT3 IN COMPLEX WITH AN 8 - SUGAR INNER CORE ANALOGUE OF NEISSERIA MENINGITIDIS MOLECULE: LPT3 LIGHT CHAIN; ? IGG2 MUS MUSCULUS 10 SASSSVRYMH 7 DTSKLAS 10 QQWNGYPPLT 5 RFGMH 17 YIGGGSSTIYYADTVKG 9 DETGSWFAY crystal 2.69A 22.84% ? 29-SEP-13 20130929 PROTEIN BINDING MECHANISM OF FARNESYLATED CAAX PROTEIN PROCESSING BY THE INTEGRAL MEMBRANE PROTEASE RCE1 MOLECULE: RAS AND A - FACTOR CONVERTING ENZYME 1, RCE1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 QHFWSTPWT 5 SYWIE 17 EIFPGSGNTNYNEKFKG 16 RGAFYSYGSSYYAMDF crystal 2.50A 22.82% FAB 08-OCT-13 20131008 VIRUS THREE - DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB MOLECULE: ENVELOPE PROTEIN E; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 09-OCT-13 20131009 VIRAL PROTEIN / IMMUNE SYSTEM PRE - FUSION STRUCTURE OF TRIMERIC HIV - 1 ENVELOPE GLYCOPROTEIN DETERMINED BY CRYO - ELECTRON MICROSCOPY MOLECULE: GP41; ENGINEERED: YES; OTHER_DETAILS: COMPLETE ECTODOMAIN OF HIV - 1 ENV FROM THE CLADE A STRAIN KNH1144 INLCUDING RESIDUES IN THE MEMBRANE PROXIMAL EXTERNAL REGION WITH THE FOLLOWING RESIDUE SUBSTITUTIONS A662E, S668N, AND S676T; ? ? HUMAN IMMUNODEFICIENCY VIRUS 1 10 KASQGGNAMT 7 DTSRRAS 5 QQFEF 7 XXXXXXX 19 XXXXXXXXXXXXXXXXXXX 26 XXXXXXXXXXXXXXXXXXXXXXXXXX ElectronMicroscopy N/A N/A FAB 18-OCT-13 20131018 HYDROLASE CRYSTAL STRUCTURE OF THE BLOOM'S SYNDROME HELICASE BLM IN COMPLEX WITH NANOBODY MOLECULE: BLOOM SYNDROME PROTEIN; FRAGMENT: CATALYTIC CORE, RESIDUES 636 - 1298; SYNONYM: BLOOM SYNDROME HELICASE, DNA HELICASE, RECQ - LIKE TYPE 2, RECQ2, RECQ PROTEIN - LIKE 3; EC: 3.6.4.12; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INNMA 16 IITSAGTTNYVDSVKG 11 VADYDMGFQSF crystal 2.79A 20.76% HC-dimer 31-OCT-13 20131031 IMMUNE SYSTEM CRYSTALLOGRAPHIC STRUCTURE OF THE HUMAN IGG1 ALPHA 2 - 6 SIALILATED FC - FRAGMENT ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 23.65% FC 31-OCT-13 20131031 HYDROLASE / IMMUNE SYSTEM MODEL OF COMPLEX BETWEEN THE E.COLI ENZYME BETA - GALACTOSIDASE AND FOUR SINGLE CHAIN FV ANTIBODY DOMAINS SCFV13R4. MOLECULE: BETA - GALACTOSIDASE; SYNONYM: BETA - GAL, LACTASE; EC: 3.2.1.23; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIGNDLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY ElectronMicroscopy N/A N/A FV 03-JAN-14 20140103 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF CD38 WITH A NOVEL CD38 - TARGETING ANTIBODY SAR650984 MOLECULE: ADP - RIBOSYL CYCLASE 1; FRAGMENT: EXTRACELLULAR DOMAIN, RESIDUES 45 - 300; SYNONYM: CYCLIC ADP - RIBOSE HYDROLASE 1, CADPR HYDROLASE 1, T10, CD38, ACYL - RIBOSE CYCLASE 1; EC: 3.2.2.5; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDVSTVVA 7 SASYRYI 9 QQHYSPPYT 5 DYWMQ 17 TIYPGDGDTGYAQKFQG 11 GDYYGSNSLDY crystal 1.53A 18.89% FAB 15-JAN-14 20140115 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB PORTION OF OLOKIZUMAB IN COMPLEX WITH IL - 6 MOLECULE: INTERLEUKIN - 6; FRAGMENT: RESIDUES 41 - 212; SYNONYM: IL - 6, B - CELL STIMULATORY FACTOR 2, BSF - 2, CTL DIFFERENTIATION FACTOR, CDF, HYBRIDOMA GROWTH FACTOR, INTERFERON BETA - 2, IFN - BETA - 2; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDIGISLS 7 NANNLAD 9 LQHNSAPYT 5 DYFMN 19 QMRNKNYQYGTYYAESLEG 9 ESYYGFTSY crystal 2.20A 17.81% FAB 22-JAN-14 20140122 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DEGLYCOSYLATED SERUM - DERIVED HUMAN IGG4 FC ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 20.70% FC 12-MAY-14 20140512 PROTEIN BINDING CRYSTAL STRUCTURE OF THE NK1 DOMAIN OF HGF IN COMPLEX WITH ANTI - HGF MONOCLONAL ANTIBODY SFN68. MOLECULE: HEPATOCYTE GROWTH FACTOR; FRAGMENT: RESIDUES 23 - 210; SYNONYM: HEPATOPOIETIN - A, SCATTER FACTOR, SF, NK1; ENGINEERED: YES; MUTATION: YES; ? ? ORYCTOLAGUS CUNICULUS 11 QASQSVSNLLA 7 GASNLES 10 QSGYYSAGAT 5 TYYMS 17 YIGTSSGTTYYANSVKG 7 GLGRINL crystal 2.62A 26.91% FAB 21-OCT-14 20141021 IMMUNE SYSTEM FAB STRUCTURE OF ANTI - HIV - 1 GP120 V2 MAB 697 ? ? ? HOMO SAPIENS 14 TGSSSNIGAHYDVH 7 GNSNRPS 11 QSYDSSLSGYV 5 TYTIS 19 RIIPIFGIVNPAQKFPGRV 12 SGVGLHFGYFDY crystal 2.48A 18.00% FAB 11-JAN-12 20120111 HYDROLASE / IMMUNE SYSTEM INHIBITING ALTERNATIVE PATHWAY COMPLEMENT ACTIVATION BY TARGETING THE EXOSITE ON FACTOR D MOLECULE: FACTOR D; ENGINEERED: YES; ? ? HOMO SAPIENS 11 ITSTDIDDDMN 7 GGNTLRP 9 LQSDSLPYT 5 NYGMN 17 WINTYTGETTYADDFKG 6 EGGVNN crystal 2.28A 19.10% FAB 11-JAN-12 20120111 HYDROLASE / IMMUNE SYSTEM INHIBITING ALTERNATIVE PATHWAY COMPLEMENT ACTIVATION BY TARGETING THE EXOSITE ON FACTOR D MOLECULE: COMPLEMENT FACTOR D; SYNONYM: ADIPSIN, C3 CONVERTASE ACTIVATOR, PROPERDIN FACTOR D; EC: 3.4.21.46; ENGINEERED: YES; ? ? HOMO SAPIENS 11 ITSTDIDDDMN 7 GGNTLRP 9 LQSDSLPYT 5 NYGMN 17 WINTYTGETTYADDFKG 6 EGGVNN crystal 2.42A 21.50% FAB 11-JAN-12 20120111 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF THE HUMAN METAPNEUMOVIRUS FUSION PROTEIN WITH NEUTRALIZING ANTIBODY IDENTIFIES A PNEUMOVIRUS ANTIGENIC SITE MOLECULE: FUSION GLYCOPROTEIN F0; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 SGDKLGDKYAS 7 QDSERPS 9 QAWDSSTAV 5 SSYMS 16 VFYSGGTTYYADAVKG 14 VLSRASGMPDAFDI crystal 3.39A 26.10% FAB 12-JAN-12 20120112 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF 3B5H10, AN ANTIBODY - SPECIFIC FOR EXTENDED POLYGLUTAMINE REPEATS (ORTHORHOMBIC FORM) ? ? ? MUS MUSCULUS 12 TLNSQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 TYGMS 17 WINTYSGVPTYVDDFKG 10 GGNNFLWFAY crystal 1.94A 18.80% FAB 18-JAN-12 20120118 PROTEIN BINDING STRUCTURE OF POM1 FAB FRAGMENT COMPLEXED WITH HUMAN PRPC FRAGMENT 120 - 230 MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: RESIDUES 120 - 230; SYNONYM: PRP, ASCR, PRP27 - 30, PRP33 - 35C; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 2.40A 25.90% FAB 26-JAN-12 20120126 IMMUNE SYSTEM / VIRAL PROTEIN STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HCV1, P2 (1) FORM MOLECULE: E2 PEPTIDE; FRAGMENT: UNP RESIDUES 51 - 62; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 8 QQRSNWIT 5 NYGMH 17 VIWFDENNKYYADSVRG 14 DISLVRDAFIYFDF crystal 1.80A 17.20% FAB 26-JAN-12 20120126 IMMUNE SYSTEM / VIRAL PROTEIN STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HCV1, C2 FORM MOLECULE: E2 PEPTIDE; FRAGMENT: UNP RESIDUES 51 - 62; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 8 QQRSNWIT 5 NYGMH 17 VIWFDENNKYYADSVRG 14 DISLVRDAFIYFDF crystal 1.80A 18.90% FAB 27-JAN-12 20120127 RNA BINDING PROTEIN / IMMUNE SYSTEM STRUCTURE OF EDITOSOME PROTEIN MOLECULE: RNA - EDITING COMPLEX PROTEIN MP81; ENGINEERED: YES; MUTATION: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LYSMG 17 AISRNGANTYYTDSVKG 18 DRFPTMEVVTIMTNEYDY crystal 2.76A 22.60% HC-dimer 03-FEB-12 20120203 RNA BINDING PROTEIN / IMMUNE SYSTEM STRUCTURE OF EDITOSOME PROTEIN MOLECULE: RNA - EDITING COMPLEX PROTEIN MP81; ENGINEERED: YES; MUTATION: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LYSMG 17 AISRNGANTYYTDSVKG 18 DRFPTMEVVTIMTNEYDY crystal 2.65A 22.60% HC-dimer 03-FEB-12 20120203 RNA BINDING PROTEIN / IMMUNE SYSTEM STRUCTURE OF EDITOSOME PROTEIN MOLECULE: RNA - EDITING COMPLEX PROTEIN MP81; ENGINEERED: YES; MUTATION: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LYSMG 17 AISRNGANTYYTDSVKG 18 DRFPTMEVVTIMTNEYDY crystal 1.97A 18.90% HC-dimer 03-FEB-12 20120203 CYTOKINE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN - 34 BOUND TO FAB1.1 MOLECULE: INTERLEUKIN - 34; FRAGMENT: ACTIVE CORE; SYNONYM: IL - 34; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQSFYFPNT 5 STWIH 17 RISPYYYYSDYADSVKG 13 GLGKGSKRGAMDY crystal 3.00A 23.20% FAB 03-FEB-12 20120203 CYTOKINE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN - 34 BOUND TO FAB2 MOLECULE: INTERLEUKIN - 34; FRAGMENT: ACTIVE CORE; SYNONYM: IL - 34; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSYLA 7 GASSRAS 9 QQYWSEPVT 5 SYGIS 17 HIDWYGGDTDYADSVKG 9 GGPDYAMDV crystal 2.61A 22.70% FAB 03-FEB-12 20120203 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MCP - 1 ANTIBODY CNTO888 MOLECULE: CNTO888 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSDAYLA 7 DASSRAT 10 HQYIQLHSFT 5 SYGIS 17 GIIPIFGTANYAQKFQG 10 YDGIYGELDF crystal 2.60A 19.40% ? 08-FEB-12 20120208 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CNTO888 FAB AND MCP - 1 MUTANT P8A MOLECULE: C - C MOTIF CHEMOKINE 2; SYNONYM: HC11, MONOCYTE CHEMOATTRACTANT PROTEIN 1, MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR, MCAF, MONOCYTE CHEMOTACTIC PROTEIN 1, MCP - 1, MONOCYTE SECRETORY PROTEIN JE, SMALL - INDUCIBLE CYTOKINE A2; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 12 RASQSVSDAYLA 7 DASSRAT 10 HQYIQLHSFT 5 SYGIS 17 GIIPIFGTANYAQKFQG 10 YDGIYGELDF crystal 2.80A 20.00% FAB 08-FEB-12 20120208 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PG16 FAB IN COMPLEX WITH V1V2 REGION FROM HIV - 1 STRAIN ZM109 MOLECULE: 1FD6 - V1V2 SCAFFOLD ZM109 HIV - 1 STRAIN; ENGINEERED: YES ? ? HOMO SAPIENS 14 QGTSSDVGGFDSVS 7 DVSHRPS 10 SSLTDRSHRI 5 KYGMH 16 LISDDGMRKYHSDSMW 26 REAGGPIWHDDVKYDFNDGYYNYHYM crystal 2.44A 20.30% FAB 16-FEB-12 20120216 BLOOD CLOTTING INHIBITOR / IMMUNE SYSTEM HEMOSTATIC EFFECT OF A MONOCLONAL ANTIBODY MAB 2021 BLOCKING THE INTERACTION BETWEEN FXA AND TFPI IN A RABBIT HEMOPHILIA MODEL MOLECULE: TISSUE FACTOR PATHWAY INHIBITOR; FRAGMENT: KUNITZ - TYPE PROTEASE INHIBITOR DOMAIN 2 (UNP RESIDUES 119 - 178); SYNONYM: TFPI, EXTRINSIC PATHWAY INHIBITOR, EPI, LIPOPROTEIN - ASSOCIATED COAGULATION INHIBITOR, LACI; ENGINEERED: YES ? ? HOMO SAPIENS 16 KSSQSLLESDGKTYLN 7 LVSILDS 9 LQATHFPQT 5 NYAMS 17 TISRSGSYSYFPDSVQG 12 LGGYDEGDAMDS crystal 1.80A 19.80% FAB 21-FEB-12 20120221 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF PRO - UPA ANTIBODY MAB - 112 ? ? ? MUS MUSCULUS 12 RASSTVSFHYLH 7 ATSNLAS 9 QHYSAYPRT 5 RYAMS 16 SITNGGSTYYSDSVKG 9 GELTYAMDY crystal 1.93A 22.40% FAB 23-FEB-12 20120223 IMMUNE SYSTEM / TRANSCRIPTION INHIBITOR CRYSTAL STRUCTURE OF YU2 GP120 CORE IN COMPLEX WITH FAB 48D AND NBD - 557 MOLECULE: GLYCOPROTEIN GP120; FRAGMENT: UNP RESIDUES 83 - 123; 199 - 301; 324 - 492; SYNONYM: ENV POLYPROTEIN, SURFACE PROTEIN GP120, SU, GLYCOPROTEIN 120, GP120, TRANSMEMBRANE PROTEIN GP41, TM, GLYCOPROTEIN 41, GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDISTWLA 7 AASTLQS 8 QQANSFFT 5 DFYMY 17 LIDPEDADTMYAEKFRG 10 DPWELNAFNV crystal 2.50A 23.30% FAB 23-FEB-12 20120223 HYDROLASE / IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH THE FAB FRAGMENT OF MAB - 112 MOLECULE: UROKINASE - TYPE PLASMINOGEN ACTIVATOR; FRAGMENT: CATALYTIC DOMAIN, UNP RESIDUES 179 - 424; SYNONYM: UROKINASE - TYPE PLASMINOGEN ACTIVATOR CHAIN B; EC: 3.4.21.73; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSTVSFHYLH 7 ATSNLAS 9 QHYSAYPRT 5 RYAMS 16 SITNGGSTYYSDSVKG 9 GELTYAMDY crystal 2.97A 24.30% FAB 24-FEB-12 20120224 IMMUNE SYSTEM HUMAN IGG1 FC FRAGMENT HETERODIMER ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.91A 20.60% FC 29-FEB-12 20120229 IMMUNE SYSTEM FAB STRUCTURE OF ANTI - VACCINIA VIRUS D8L ANTIGEN MOUSE IGG2A LA5 ? ? IGG2 MUS MUSCULUS 10 SASSSVSYMY 7 DTSNLAS 9 QQWTSYPLT 5 FYWMH 17 MIDPSESESRLNQKFKD 10 SNYRYDYFDV crystal 1.60A 20.00% FAB 23-MAR-12 20120323 IMMUNE SYSTEM NERVE GROWTH FACTOR IN COMPLEX WITH FAB FROM HUMANIZED VERSION OF MOUSE MAB 911 (TANEZUMAB) MOLECULE: BETA - NERVE GROWTH FACTOR; SYNONYM: BETA - NGF; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISNNLN 7 YTSRFHS 9 QQEHTLPYT 5 GYDLN 16 IIWGDGTTDYNSAVKS 13 GGYWYATSYYFDY crystal 2.48A 20.30% FAB 27-MAR-12 20120327 IMMUNE SYSTEM NERVE GROWTH FACTOR IN COMPLEX WITH FAB FROM MOUSE MAB 911 MOLECULE: BETA - NERVE GROWTH FACTOR; SYNONYM: BETA - NGF; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDISNHLN 7 YISRFHS 9 QQSKTLPYT 5 GYDIN 16 MIWGDGTTDYNSALKS 13 GGYYYGTSYYFDY crystal 2.50A 20.90% FAB 27-MAR-12 20120327 OXIDOREDUCTASE / IMMUNE SYSTEM CA1698 CAMEL ANTIBODY FRAGMENT IN COMPLEX WITH DHFR MOLECULE: DIHYDROFOLATE REDUCTASE; EC: 1.5.1.3; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 VYKMT 16 LITTNNNTMTVDSVKG 9 NRGLAGPAY crystal 2.50A 17.40% HC-dimer 05-APR-12 20120405 OXIDOREDUCTASE / IMMUNE SYSTEM STRUCTURE OF NB113 BOUND TO APODHFR MOLECULE: DIHYDROFOLATE REDUCTASE; EC: 1.5.1.3; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 17 AITWGGSTTLYADSVKG 19 DGSQYRSTYSFRDKPDYGS crystal 2.20A 17.30% HC-dimer 06-APR-12 20120406 OXIDOREDUCTASE / IMMUNE SYSTEM BINDING OF NB113 CAMELID ANTIBODY FRAGMENT WITH THE BINARY DHFR:FOLATE COMPLEX MOLECULE: DIHYDROFOLATE REDUCTASE; EC: 1.5.1.3; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 17 AITWGGSTTLYADSVKG 19 DGSQYRSTYSFRDKPDYGS crystal 1.75A 18.80% HC-dimer 06-APR-12 20120406 TRANSPORT PROTEIN STRUCTURE OF THE N - AND C - TERMINAL TRIMMED CLC - EC1 CL - / H+ ANTIPORTER AND FAB COMPLEX MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.40A 24.10% FAB 13-APR-12 20120413 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A DISEASE - ASSOCIATED ANTI - HUMAN GM - CSF AUTOANTIBODY MB007 ? LAMBDA IGG1 HOMO SAPIENS 13 SGSSSNIGNSYVY 7 RNNRRPS 11 ATWDDSLSGRL 5 RYGIK 17 WINTRSGVPAYAQGFTG 18 RPPRFYDKTEYWEDGFDV crystal 1.97A 22.60% FAB 16-APR-12 20120416 IMMUNE SYSTEM A MOLECULAR BASIS FOR NEGATIVE REGULATION OF THE GLUCAGON RECEPTOR MOLECULE: GLUCAGON RECEPTOR; SYNONYM: GL - R; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGIRNDLG 7 AASSLES 9 LQHNSNPLT 5 SYGMH 17 VMYYDGSNKDYVDSVKG 19 EKDHYDILTGYNYYYGLDV crystal 2.64A 23.40% FAB 20-APR-12 20120420 IMMUNE SYSTEM / VIRAL PROTEIN VACCINIA VIRUS D8L IMV ENVELOPE PROTEIN IN COMPLEX WITH FAB OF MURINE IGG2A LA5 MOLECULE: IMV MEMBRANE PROTEIN; FRAGMENT: UNP RESIDUES 1 - 261; SYNONYM: D8L IMV ENVELOPE PROTEIN; ENGINEERED: YES ? IGG2 MUS MUSCULUS 10 SASSSVSYMY 7 DTSNLAS 9 QQWTSYPLT 5 FYWMH 17 MIDPSESESRLNQKFKD 10 SNYRYDYFDV crystal 2.10A 20.30% FAB 24-APR-12 20120424 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB CR6261 (SOMATIC HEAVY CHAIN WITH GERMLINE - REVERTED LIGHT CHAIN) ? LAMBDA ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 12 GTWDSSLSAYVV 5 SYAIS 17 GIIPIFGTTKYAPKFQG 12 HMGYQVRETMDV crystal 2.85A 23.10% FAB 26-APR-12 20120426 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN IGE - FC (EPSILON) 3 - 4 BOUND TO ITS B CELL RECEPTOR DERCD23 ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCER2, CD23A, CLEC4J, FCE2, IGEBF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.10A 26.50% FC 03-MAY-12 20120503 IMMUNE SYSTEM MOLECULAR BASIS OF INFECTIVITY OF 2009 PANDEMIC H1N1 INFLUENZA A VIRUSES MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 18 - 520; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASESVSNFIN 7 TASNKGT 12 QQTKEVPYGTFG 5 DYDMS 17 GILGGSERSYYRDSVKG 5 HSWGG crystal 2.81A 23.50% FAB 06-MAY-12 20120506 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A TGEV CORONAVIRUS SPIKE FRAGMENT IN COMPLEX WITH THE TGEV NEUTRALIZING MONOCLONAL ANTIBODY 1AF10 MOLECULE: SPIKE PROTEIN; FRAGMENT: RESIDUES 481 - 650; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTSIH 7 YASESIS 9 QQTDSWPTT 5 SSWMN 17 RIYPGDGETNYSEKFKG 13 GGYRYDPYYAMDY crystal 3.00A 21.80% FAB 08-MAY-12 20120508 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THERAPEUTIC ANTIBODY MORAB - 009 ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSKHPLT 5 GYTMN 17 LITPYNGASSYNQKFRG 10 GGYDGRGFDY crystal 1.75A 20.80% FAB 08-MAY-12 20120508 IMMUNE SYSTEM STRUCTURE OF THE TETHERED N - TERMINUS OF ALZHEIMER'S DISEASE A PEPTIDE MOLECULE: COLICIN - E7 IMMUNITY PROTEIN; SYNONYM: IMME7, MICROCIN - E7 IMMUNITY PROTEIN; ? ? MUS MUSCULUS 16 RSSQTILHSNGNTYLE 7 KVSKRFS 9 FQGSRVPLT 7 TSRVGVS 16 HIYWDDDKRYNPSLES 15 RGFYGRKYEVNHFDY crystal 2.57A 22.60% FAB 09-MAY-12 20120509 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MSLN7 - 64 MORAB - 009 FAB COMPLEX MOLECULE: MESOTHELIN; SYNONYM: CAK1 ANTIGEN, PRE - PRO - MEGAKARYOCYTE - POTENTIATING FACTOR, MEGAKARYOCYTE - POTENTIATING FACTOR, MPF, MESOTHELIN, CLEAVED FORM; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSKHPLT 5 GYTMN 17 LITPYNGASSYNQKFRG 10 GGYDGRGFDY crystal 2.65A 17.90% FAB 09-MAY-12 20120509 IMMUNE SYSTEM FAB STRUCTURE OF A NEUTRALIZING ANTIBODY L1 FROM AN EARLY SUBTYPE A HIV - 1 INFECTED PATIENT ? ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 DVTNRPS 10 AAYTVASTLL 5 DFGMN 17 FVPFDRRINYYAESVRG 16 HRSQWNFWPREGGLDH crystal 1.70A 18.80% FAB 12-MAY-12 20120512 IMMUNE SYSTEM FAB STRUCTURE OF A NEUTRALIZING ANTIBODY L3 FROM AN EARLY SUBTYPE A HIV - 1 INFECTED PATIENT ? ? ? HOMO SAPIENS 14 TGTTSDVGTYNFVS 7 DVTNRPS 10 AAYTVASTLL 5 DFGMN 17 FVPFDRRINYYAESVRG 16 HRSQWNFWPREGGLDH crystal 2.49A 21.00% FAB 12-MAY-12 20120512 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN BTN3A1 ECTODOMAIN IN COMPLEX WITH THE 20.1 SINGLE CHAIN ANTIBODY MOLECULE: BUTYROPHILIN SUBFAMILY 3 MEMBER A1; FRAGMENT: ECTODOMAIN (UNP RESIDUES 30 - 246); ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQNINLWLS 7 RASNLHT 9 QQGHSYPYT 3 LWL 13 KLLIYRASNLHTG 26 QGHSYPYTFGGGTKLDIKRAQVQLQE crystal 3.14A 25.60% scFv 18-MAY-12 20120518 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN BTN3A1 ECTODOMAIN IN COMPLEX WITH THE 103.2 SINGLE CHAIN ANTIBODY MOLECULE: BUTYROPHILIN SUBFAMILY 3 MEMBER A1; FRAGMENT: ECTODOMAIN (UNP RESIDUES 30 - 246); ENGINEERED: YES; ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 3.52A 37.50% scFv 19-MAY-12 20120519 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF A FLUORESCEIN - FAB COMPLEX CRYSTALLIZED IN 2 - METHYL - 2,4 - PENTANEDIOL CRYSTALLIZED IN 2 - METHYL - 2,4 - PENTANEDIOL KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSQGNTYLR 7 KVSNRFS 9 SQSTHVPWT 5 DYWMN 19 QIRNKPYNYETYYSDSVKG 7 SYYGMDY crystal 2.70A 21.50% FAB 10-APR-89 19890410 HYDROLASE / IMMUNE SYSTEM, INHIBITOR CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPP4, DPP - IV, CD26) IN COMPLEX WITH 11A19 FAB MOLECULE: DIPEPTIDYL PEPTIDASE 4; SYNONYM: BILE CANALICULUS DOMAIN - SPECIFIC MEMBRANE GLYCOPROTEIN, DIPEPTIDYL PEPTIDASE IV, DPP IV, GP110 GLYCOPROTEIN, T - CELL ACTIVATION ANTIGEN CD26, DIPEPTIDYL PEPTIDASE 4 MEMBRANE FORM, DIPEPTIDYL PEPTIDASE IV MEMBRANE FORM, DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM, DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM, DIPEPTIDYL PEPTIDASE 4 60 KDA SOLUBLE FORM, DIPEPTIDYL PEPTIDASE IV 60 KDA SOLUBLE FORM; EC: 3.4.14.5; ENGINEERED: YES; ? ? MUS MUSCULUS 10 RASSSVNNMH 7 GTSNLAS 9 QQWSNHPPT 5 DYNIN 17 VVIPKYGTTNYNQKFQG 8 FRDVFFDV crystal 2.40A 27.20% FV 01-JUN-12 20120601 HYDROLASE / IMMUNE SYSTEM, INHIBITOR CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPP4, DPP - IV, CD26) IN COMPLEX WITH FAB + SITAGLIPTIN MOLECULE: DIPEPTIDYL PEPTIDASE 4; SYNONYM: BILE CANALICULUS DOMAIN - SPECIFIC MEMBRANE GLYCOPROTEIN, DIPEPTIDYL PEPTIDASE IV, DPP IV, GP110 GLYCOPROTEIN, T - CELL ACTIVATION ANTIGEN CD26, DIPEPTIDYL PEPTIDASE 4 MEMBRANE FORM, DIPEPTIDYL PEPTIDASE IV MEMBRANE FORM, DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM, DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM, DIPEPTIDYL PEPTIDASE 4 60 KDA SOLUBLE FORM, DIPEPTIDYL PEPTIDASE IV 60 KDA SOLUBLE FORM; EC: 3.4.14.5; ENGINEERED: YES; ? ? MUS MUSCULUS 10 RASSSVNNMH 7 GTSNLAS 9 QQWSNHPPT 5 DYNIN 17 VVIPKYGTTNYNQKFQG 8 FRDVFFDV crystal 2.90A 28.80% FAB 01-JUN-12 20120601 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DENV1 - E111 FAB FRAGMENT BOUND TO DENV - 1 DIII (WESTERN PACIFIC - 74 STRAIN) . MOLECULE: ENVELOPE PROTEIN E; FRAGMENT: UNP RESIDUES 573 - 679; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDHYGNSFIY 7 LASNLES 9 QQNNEDPYT 5 NWWMH 17 RIDPNSDVNKYNEKFEN 9 WFFPWYFDV crystal 3.80A 23.70% FAB 01-JUN-12 20120601 TRANSPORT PROTEIN STRUCTURE OF ECCLC E148A MUTANT IN GLUTAMATE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.02A 23.90% FAB 04-JUN-12 20120604 OXIDOREDUCTASE / PROTEIN BINDING ENHANCING DHFR CATALYSIS BY BINDING OF AN ALLOSTERIC REGULATOR NANOBODY (NB179) MOLECULE: DIHYDROFOLATE REDUCTASE; EC: 1.5.1.3; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 16 ISWSGSNTYYADSAKG 20 PGRPHGSSWSLNKKGQGYDY crystal 2.80A 22.10% HC-dimer 06-JUN-12 20120606 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY C05 ? ? ? HOMO SAPIENS 11 QASQDIRKFLN 7 DASNLQR 9 QQYDGLPFT 7 ESTLSYY 17 WLSIINAGGGDIDYADS 26 CAKHMSMQQVVSAGWERADLVGDAFD crystal 2.30A 21.40% FAB 19-JUN-12 20120619 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY C05 BOUND TO H3 INFLUENZA HEMAGGLUTININ, HA1 SUBUNIT MOLECULE: HEMAGGLUTININ HA1 CHAIN; FRAGMENT: UNP RESIDUES 59 - 325; SYNONYM: HEMAGGLUTININ RECEPTOR BINDING SUBUNIT HA1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIRKFLN 7 DASNLQR 9 QQYDGLPFT 7 ESTLSYY 17 WLSIINAGGGDIDYADS 26 CAKHMSMQQVVSAGWERADLVGDAFD crystal 2.95A 21.40% FAB 21-JUN-12 20120621 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PGT121 FAB ? ? ? HOMO SAPIENS 11 GEKSLGSRAVQ 7 NNQDRPS 15 YYCHIWDSRVPTKWV 5 DSYWS 16 YVHKSGDTNYSPSLKS 24 TLHGRRIYGIVAFNEWFTYFYMDV crystal 3.00A 21.80% FAB 24-JUN-12 20120624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10 - 1074 FAB ? ? ? HOMO SAPIENS 11 GRQALGSRAVQ 7 NNQDRPS 15 YYCHMWDSRSGFSWS 5 NYYWT 16 YISDRESATYNPSLNS 24 ARRGQRIYGVVSFGEFFYYYSMDV crystal 1.90A 18.90% FAB 24-JUN-12 20120624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PGT121 FAB BOUND TO A COMPLEX - TYPE SIALYLATED N - GLYCAN TYPE SIALYLATED N - GLYCAN ? ? HOMO SAPIENS 11 GEKSLGSRAVQ 7 NNQDRPS 15 YYCHIWDSRVPTKWV 5 DSYWS 16 YVHKSGDTNYSPSLKS 24 TLHGRRIYGIVAFNEWFTYFYMDV crystal 2.40A 20.30% FAB 25-JUN-12 20120625 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB CR9114 ? LAMBDA ? HOMO SAPIENS 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 NYAIS 17 GISPIFGSTAYAQKFQG 12 HGNYYYYSGMDV crystal 2.05A 20.20% FAB 25-JUN-12 20120625 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB CR9114 IN COMPLEX WITH A H5N1 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 347 - 520; SYNONYM: HEMAGGLUTININ MEMBRANE FUSION SUBUNIT HA2; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 NYAIS 17 GISPIFGSTAYAQKFQG 12 HGNYYYYSGMDV crystal 1.71A 20.00% FAB 25-JUN-12 20120625 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA B / FLORIDA / 4 / 2006 HEMAGGLUTININ FAB CR8071 COMPLEX MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 46 - 343; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGTNYVY 7 RSYQRPS 11 ATWDDSLDGWV 5 ESGIT 17 WISGYSGDTKYAQKLQG 16 DVQYSGSYLGAYYFDY crystal 2.50A 23.20% FAB 25-JUN-12 20120625 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA B / BRISBANE / 60 / 2008 HEMAGGLUTININ FAB CR8059 COMPLEX MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 363 - 538; SYNONYM: HEMAGGLUTININ MEMBRANE FUSION SUBUNIT HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGTNYVY 7 RSYQRPS 11 ATWDDSLNGWV 5 ESGIT 17 WISGYSGDTKYAQKLQG 16 DVQYSGSYLGAYYFDY crystal 5.65A 30.80% FAB 25-JUN-12 20120625 IMMUNE SYSTEM INFLUENZA B HA ANTIBODY (FAB) CR8033 ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASTRAT 9 QQYGSSPWT 5 EYTMH 17 GINWKGNFMGYADSVQG 18 DRLESSAMDILEGGTFDI crystal 1.90A 19.60% FAB 25-JUN-12 20120625 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GERMLINE ANTIBODY PGT121 - GL FAB ? ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 12 QVWDSSSDHPWV 5 SYYWS 16 YIYYSGSTNYNPSLKS 24 TQQGKRIYGVVSFGDYYYYYYMDV crystal 2.42A 19.50% FAB 25-JUN-12 20120625 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY C05 BOUND TO H3 INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: UNP RESIDUES 346 - 519; SYNONYM: HEMAGGLUTININ FUSION SUBUNIT HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIRKFLN 7 DASNLQR 9 QQYDGLPFT 7 ESTLSYY 17 WLSIINAGGGDIDYADS 26 CAKHMSMQQVVSAGWERADLVGDAFD crystal 4.10A 31.00% FAB 25-JUN-12 20120625 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR9114 BOUND TO H7 INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 349 - 524; SYNONYM: HEMAGGLUTININ MEMBRANE FUSION SUBUNIT HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 NYAIS 17 GISPIFGSTAYAQKFQG 12 HGNYYYYSGMDV crystal 5.75A 31.50% FAB 25-JUN-12 20120625 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR9114 BOUND TO H3 INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 346 - 519; SYNONYM: HEMAGGLUTININ MEMBRANE FUSION SUBUNIT HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 NYAIS 17 GISPIFGSTAYAQKFQG 12 HGNYYYYSGMDV crystal 5.25A 36.60% FAB 25-JUN-12 20120625 IMMUNE SYSTEM CRYSTAL STRUCTURE OF C11 FAB, AN ADCC MEDIATING ANTI - HIV - 1 ANTIBODY. ? ? ? HOMO SAPIENS 16 RSSQSLLHSNGYNYLD 7 LGSNRAS 8 MQALQAVG 5 SYSMN 17 SISNTSTYIYYADSVEG 22 ANQHFDWLLSLLGGYHYYGMDV crystal 2.66A 25.60% FAB 06-JUL-12 20120706 IMMUNE SYSTEM CRYSTAL STRUCTURE OF N26_I1 FAB, AN ADCC MEDIATING ANTI - HIV - 1 ANTIBODY. ? ? ? HOMO SAPIENS 11 SGDNLRDGYAS 7 RDDKRPS 9 QAWASTTVI 5 SYFIS 17 GITPLLGTANYAQKFQG 16 TVYYDILTGLYTNFHY crystal 2.00A 19.10% FAB 06-JUL-12 20120706 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TNF - ALPHA IN COMPLEX WITH INFLIXIMAB FAB FRAGMENT MOLECULE: TUMOR NECROSIS FACTOR; FRAGMENT: TUMOR NECROSIS FACTOR, SOLUBLE FORM; SYNONYM: TNF - ALPHA; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQFVGSSIH 7 YASESMS 9 QQSHSWPFT 5 NHWMN 19 EIRSKSINSATHYAESVKG 9 NYYGSTYDY crystal 2.60A 19.10% FAB 15-JUL-12 20120715 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE THERAPEUTICAL ANTIBODY FRAGMENT OF CANAKINUMAB IN ITS UNBOUND STATE ? ? ? HOMO SAPIENS 11 RASQSIGSSLH 7 YASQSFS 9 HQSSSLPFT 5 VYGMN 17 IIWYDGDNQYYADSVKG 9 DLRTGPFDY crystal 1.83A 19.50% ? 18-JUL-12 20120718 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY AP33 MOLECULE: E2 PEPTIDE; FRAGMENT: E2 PEPTIDE; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASESVDGYGNSFLH 7 LASNLNS 9 QQNNVDPWT 5 SGYWN 16 YISYSGSTYYNLSLRS 10 ITTTTYAMDY crystal 2.50A 18.00% FAB 18-JUL-12 20120718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB IN COMPLEX WITH AN HIV - 1 GP41 PEPTIDE MOLECULE: GP41 MPER PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.10A 18.10% FAB 19-JUL-12 20120719 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IL - 1BETA IN COMPLEX WITH THE THERAPEUTIC ANTIBODY BINDING FRAGMENT OF CANAKINUMAB MOLECULE: INTERLEUKIN - 1 BETA; FRAGMENT: HUMAN INTERLEUKIN - 1BETA; SYNONYM: IL - 1 BETA, CATABOLIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGSSLH 7 YASQSFS 9 HQSSSLPFT 5 VYGMN 17 IIWYDGDNQYYADSVKG 9 DLRTGPFDY crystal 2.03A 22.70% ? 19-JUL-12 20120719 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE THERAPEUTIC ANTIBODY BINDING FRAGMENT OF GEVOKIZUMAB IN ITS UNBOUND STATE ? ? ? HOMO SAPIENS, MUS MUSCULUS 11 RASQDISNYLS 7 YTSKLHS 9 LQGKMLPWT 7 TSGMGVG 16 HIWWDGDESYNPSLKS 10 NRYDPPWFVD crystal 1.90A 18.40% ? 19-JUL-12 20120719 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IL - 1BETA IN COMPLEX WITH THERAPEUTIC ANTIBODY BINDING FRAGMENT OF GEVOKIZUMAB MOLECULE: INTERLEUKIN - 1 BETA; FRAGMENT: UNP RESIDUES 117 - 267; SYNONYM: IL - 1 BETA, CATABOLIN; ENGINEERED: YES; ? ? HOMO SAPIENS, MUS MUSCULUS 11 RASQDISNYLS 7 YTSKLHS 9 LQGKMLPWT 7 TSGMGVG 16 HIWWDGDESYNPSLKS 10 NRYDPPWFVD crystal 1.81A 20.30% ? 19-JUL-12 20120719 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF VOLTAGE SENSING DOMAIN OF CI - VSP WITH FRAGMENT ANTIBODY (R217E, 2.5 A) MOLECULE: VOLTAGE - SENSOR CONTAINING PHOSPHATASE; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQYFYWPIT 5 SSSIH 17 SISSYYGYTSYADSVKG 10 SYSWSYAIDY crystal 2.50A 20.30% ? 20-JUL-12 20120720 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF VOLTAGE SENSING DOMAIN OF CI - VSP WITH FRAGMENT ANTIBODY (R217E, 2.8 A) MOLECULE: VOLTAGE - SENSOR CONTAINING PHOSPHATASE; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQYFYWPIT 5 SSSIH 17 SISSYYGYTSYADSVKG 10 SYSWSYAIDY crystal 2.80A 20.90% ? 20-JUL-12 20120720 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF VOLTAGE SENSING DOMAIN OF CI - VSP WITH FRAGMENT ANTIBODY (WT, 3.8 A) MOLECULE: VOLTAGE - SENSOR CONTAINING PHOSPHATASE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQHQYNSLI 5 YSSIH 17 YISPSSGSTYYADSVKG 15 KQYSYWRDSYWAMDY crystal 3.58A 25.00% ? 20-JUL-12 20120720 IMMUNE SYSTEM STRUCTURE OF THE BROADLY NEUTRALIZING ANTIBODY AP33 IN COMPLEX WITH ITS HCV EPITOPE (E2 RESIDUES 412 - 423) MOLECULE: GENOME POLYPROTEIN; FRAGMENT: RESIDUES 412 - 423 OF HCV E2; SYNONYM: CORE PROTEIN P21, CAPSID PROTEIN C, P21, CORE PROTEIN P19, ENVELOPE GLYCOPROTEIN E1, GP32, GP35, ENVELOPE GLYCOPROTEIN E2, NS1, GP68, GP70, P7, PROTEASE NS2 - 3, P23; EC: 3.4.22. -; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASESVDGYGNSFLH 7 LASNLNS 9 QQNNVDPWT 5 SGYWN 16 YISYSGSTYYNLSLRS 10 ITTTTYAMDY crystal 1.80A 17.90% FAB 25-JUL-12 20120725 IMMUNE SYSTEM STRUCTURE OF THE BROADLY NEUTRALIZING ANTIBODY AP33 IN COMPLEX WITH ITS HCV EPITOPE (E2 RESIDUES 411 - 424) MOLECULE: GENOME POLYPROTEIN; FRAGMENT: UNP RESIDUES 94 - 107; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASESVDGYGNSFLH 7 LASNLNS 9 QQNNVDPWT 3 YWN 16 YISYSGSTYYNLSLRS 10 ITTTTYAMDY crystal 2.51A 24.40% FAB 25-JUL-12 20120725 IMMUNE SYSTEM STRUCTURE OF THE BROADLY NEUTRALIZING ANTIBODY AP33 ? ? ? MUS MUSCULUS 15 RASESVDGYGNSFLH 7 LASNLNS 9 QQNNVDPWT 5 SGYWN 16 YISYSGSTYYNLSLRS 10 ITTTTYAMDY crystal 2.65A 24.70% FAB 26-JUL-12 20120726 PROTEIN BINDING, IMMUNE SYSTEM MALARIA INVASION MACHINERY PROTEIN - NANOBODY COMPLEX MOLECULE: MYOSIN A TAIL DOMAIN INTERACTING PROTEIN; FRAGMENT: C - TERMINAL DOMAIN (UNP RESIDUES 137 - 204); ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SNYAMG 17 GITGSGRSQYYADSVKG 15 RVVPVFSDSTKGYVY crystal 1.60A 18.20% HC-dimer 03-AUG-12 20120803 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CALCIUM2+ - BOUND HUMAN IGE - FC (EPSILON) 3 - 4 BOUND TO ITS B CELL RECEPTOR DERCD23 ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCER2, CD23A, CLEC4J, FCE2, IGEBF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.30A 27.50% FC 13-AUG-12 20120813 IMMUNE SYSTEM STRUCTURE OF THE ANTI - PTAU FAB (PT231 / PS235_1) IN COMPLEX WITH PHOSPHOEPITOPE PT231 / PS235 MOLECULE: PHOSPHO - PEPTIDE; FRAGMENT: PHOSPHO - PEPTIDE; ENGINEERED: YES; ? ? GALLUS GALLUS 8 SGSDYDYG 7 YWNDKRP 12 CGAYDGSAGGGI 5 SYQMM 17 GITSRGGVTGYGSAVKG 18 PALDSDQCGFPEAGCIDA crystal 1.90A 18.10% FAB 14-AUG-12 20120814 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HETEROSUBTYPIC FAB S139 / 1 IN COMPLEX WITH INFLUENZA A H3 HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: UNP RESIDUES 347 - 522; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQNVDTNVA 7 SASNRYS 9 QQYNSYPYT 5 SYWIE 17 EILPEIGMTNYNENFKG 9 PYDYSWFAY crystal 2.95A 20.90% FAB 16-AUG-12 20120816 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HETEROSUBTYPIC FAB S139 / 1 ? ? ? MUS MUSCULUS 11 KASQNVDTNVA 7 SASNRYS 9 QQYNSYPYT 5 SYWIE 17 EILPEIGMTNYNENFKG 9 PYDYSWFAY crystal 2.05A 16.00% FAB 16-AUG-12 20120816 VIRAL PROTEIN CHIKUNGUNYA VIRUS NEUTRALIZING ANTIBODY 9.8B FAB FRAGMENT ? ? ? MUS MUSCULUS 10 SASSSVTYMY 7 DTSNLAS 9 QQRTNYPLT 5 SKWMH 17 NIDPSDSETHYNQKFKD 9 GVTRGYFDV crystal 3.00A 32.50% FAB 22-AUG-12 20120822 IMMUNE SYSTEM STRUCTURE BASED DESIGN OF SUB - NANOMOLAR AFFINITY ANTI - METHAMPHETAMINE SINGLE CHAIN ANTIBODIES. ? ? ? MUS MUSCULUS 17 SVTGDSVTSGYWSWIRQ 7 GSTYYNP 15 YCTYFDSDDYAMEYW 5 SGYWS 16 YISYRGSTYYNPSLKS 26 FDSDDYAMEYWGQGTSVTVSGGGSQI crystal 2.00A 19.70% scFv 23-AUG-12 20120823 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF IGE COMPLEXED WITH E2_79, AN ANTI - IGE INHIBITOR ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; ORGANISM_TAXID: 562; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; EXPRESSION_SYSTEM_TAXID: 7108; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS 0 0 0 0 0 0 crystal 4.24A 27.30% FC 24-AUG-12 20120824 IMMUNE SYSTEM STRUCTURE OF A COMPLEX OF HUMAN IL - 23 WITH 3 NANOBODIES (LLAMA VHHS) MOLECULE: INTERLEUKIN - 12 SUBUNIT BETA; SYNONYM: IL - 12B, CYTOTOXIC LYMPHOCYTE MATURATION FACTOR 40 KDA SUBUNIT, CLMF P40, IL - 12 SUBUNIT P40, NK CELL STIMULATORY FACTOR CHAIN 2, NKSF2; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAIA 17 GIDSGDGSAYYADSVKG 16 VRTGWGLNAPDYAMDY crystal 2.55A 18.40% HC-dimer 27-AUG-12 20120827 IMMUNE SYSTEM H5.3 FAB STRUCTURE ? ? ? HOMO SAPIENS 11 SGDTLGDKYVC 7 QDTKRPS 9 QAWDSSSFV 6 SSYWWS 16 EIYHSGNTNYNPSLKS 14 VALFDILTGGWFDP crystal 2.25A 17.40% FAB 27-AUG-12 20120827 IMMUNE SYSTEM AN ENGINEERED DISULFIDE BOND REVERSIBLY TRAPS THE IGE - FC3 - 4 IN A CLOSED, NON - RECEPTOR BINDING CONFORMATION ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER; EXPRESSION_SYSTEM_TAXID: 7111 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.61A 19.20% FC 28-AUG-12 20120828 IMMUNE SYSTEM CQFD MEDITOPE MOLECULE: CQFD MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS,HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.24A 18.40% FAB 31-AUG-12 20120831 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 3BNC60 FAB WITH P61A MUTATION ? ? ? HOMO SAPIENS 7 QANGYLN 7 DGSKLER 8 QVYEFIVP 5 DHFIH 19 WINPKTGQPNNARQFQGRV 12 ARQRSDFWDFDV crystal 2.65A 21.50% FAB 31-AUG-12 20120831 IMMUNE SYSTEM CQYN MEDITOPE - CETUXIMAB FAB MOLECULE: CQYN MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS,HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.20A 17.50% FAB 31-AUG-12 20120831 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY 1F1 BOUND TO THE 1918 INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: UNP RESIDUES 345 - 520; SYNONYM: HEMAGGLUTININ MEMBRANE FUSION SUBUNIT; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSYTVN 7 SLNQRPS 12 AAWDDSLSAHVV 5 SYAMH 17 VISYDGRNKYYADSVKG 17 ELLMDYYDHIGYSPGPT crystal 3.29A 22.10% ? 04-SEP-12 20120904 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - INFLUENZA VIRUS ANTIBODY 1F1 ? ? ? HOMO SAPIENS 13 SGSSSNIGSYTVN 7 SLNQRPS 12 AAWDDSLSAHVV 5 SYAMH 17 VISYDGRNKYYADSVKG 17 ELLMDYYDHIGYSPGPT crystal 1.45A 18.20% ? 04-SEP-12 20120904 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SCFV - 2D10 IN COMPLEX WITH METHYL ALPHA - D - MANNOPYRANOSIDE ? ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.40A 22.90% scFv 08-SEP-12 20120908 IMMUNE SYSTEM CRYSTAL STRUCTURE AND COMPUTATIONAL MODELING OF THE FAB FRAGMENT FROM THE PROTECTIVE ANTI - RICIN MONOCLONAL ANTIBODY RAC18 ? ? ? MUS MUSCULUS 11 KASQDVTSAVA 7 SASYRYT 9 QQHYGTPLT 5 DYYVN 17 LIIPSNGGTTYNQKFRG 10 RGLTGALFAY crystal 1.90A 19.50% FAB 11-SEP-12 20120911 IMMUNE SYSTEM STRUCTURE OF POM1 FAB FRAGMENT COMPLEXED WITH MOUSE PRPC FRAGMENT 120 - 230 MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: C - TERM FRAGMENT; SYNONYM: PRP, PRP27 - 30, PRP33 - 35C; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 1.90A 20.10% FAB 21-SEP-12 20120921 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF NON - NEUTRALIZING AND ADCC - POTENT ANTIBODY N5 - I5 IN COMPLEX WITH HIV - 1 CLADE A / E GP120 AND SCD4. MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGTSSDVGSYNFVS 7 EVSERPS 11 SSYAGSTTFRV 5 TYAMS 17 SINNSGRNTFSADSVKG 10 DLRLGGGSDY crystal 1.85A 18.40% FAB 24-SEP-12 20120924 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FC - FRAGMENT OF HUMAN IGG2 ANTIBODY (PRIMITIVE CRYSTAL FORM) ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.04A 20.00% FC 26-SEP-12 20120926 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FC - FRAGMENT OF HUMAN IGG2 ANTIBODY (CENTERED CRYSTAL FORM) ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.40A 30.10% FC 26-SEP-12 20120926 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A CONFORMATION - DEPENDENT RABBIT IGG FAB SPECIFIC FOR AMYLOID PREFIBRILLAR OLIGOMERS MOLECULE: ANTIGEN BINDING FRAGMENT, IMMUNOGLOBULIN IGG - HEAVY CHAIN; ENGINEERED: YES; ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; ORGANISM_COMMON: RABBIT; ORGANISM_TAXID: 9986; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; MOL_ID: 2; ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; ORGANISM_COMMON: RABBIT; ORGANISM_TAXID: 9986; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 11 QASQSISSYLA 7 ETSTLAS 11 QSTYENPTYVS 0 N/A 0 N/A 0 N/A crystal 1.54A 20.00% LC-dimer 27-SEP-12 20120927 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A LOOP DELETED MUTANT OF HUMAN MADCAM - 1 D1D2 COMPLEXED WITH FAB 10G3 MOLECULE: MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; SYNONYM: MADCAM - 1, HMADCAM - 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGIGRNIG 7 HGTNLKD 9 IQYVQFPYT 6 SGYYWN 16 YISYDGSNNYNPSLKN 9 ASDSDGFAY crystal 2.87A 20.30% FAB 28-SEP-12 20120928 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN MADCAM - 1 D1D2 COMPLEXED WITH FAB PF - 547659 MOLECULE: MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; SYNONYM: MADCAM - 1, HMADCAM - 1; ENGINEERED: YES ? ? HOMO SAPIENS 16 KSSQSLLHTDGTTYLY 7 EVSNRFS 9 MQNIQLPWT 5 SYGIN 17 WISVYSGNTNYAQKVQG 15 EGSSSSGDYYYGMDV crystal 2.30A 15.80% FAB 01-OCT-12 20121001 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 3E5 IGG3 FAB FROM MUS MUSCULUS MOLECULE: KAPPA LIGHT CHAIN VARIABLE REGION, ANTI - COLORECTAL CARCINOMA LIGHT CHAIN; ENGINEERED: YES; KAPPA IGG3 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVANRFS 9 SQSTHVPWT 5 NYFMS 17 VITSNGDNTYYPDTVKG 11 RDSSASLYFDY crystal 2.45A 21.10% FAB 02-OCT-12 20121002 VIRAL PROTEIN LLAMA VHH - 02 BINDER OF ORF49 (RBP) FROM LACTOCOCCAL PHAGE TP901 - 1 MOLECULE: BPP; SYNONYM: BASEPLATE PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYAMG 16 ISQTGSHTYYRNSVKG 14 GDNYYYTRTYEYDY crystal 1.65A 16.80% HC-dimer 04-OCT-12 20121004 VIRAL PROTEIN COMPLEX OF LACTOCOCCAL PHAGE TP901 - 1 WITH A LLAMA VHH (VHH17) BINDER (NANOBODY) MOLECULE: BPP; SYNONYM: BASEPLATE PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAIG 17 YISMSDGRTYVADSVTG 22 GRFVTFGSAWSFVGGGPYGIDY crystal 1.75A 19.80% HC-dimer 04-OCT-12 20121004 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 8F8 IN COMPLEX A H2N2 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNPVN 7 ADEHRPS 13 AAWDDSLSGPAVV 5 SYVMH 17 VIWYDGSKTYFADSMRG 21 QQDSGYSGPEVSYYSHYGMDV crystal 3.00A 23.20% FAB 04-OCT-12 20121004 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 8M2 IN COMPLEX WITH A H2N2 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVAGNLA 7 GASTRAT 10 QQYNNWPPWT 5 SYTIT 17 GITPIFGSPNYAQRFQD 14 VGGEWGSGRYYLDH crystal 3.11A 19.50% FAB 05-OCT-12 20121005 IMMUNE SYSTEM ANTI ROTAVIRUS ANTIBODY ? ? ? HOMO SAPIENS 11 RASQSISNYLN 7 AATSLQS 8 QKTLRTWT 5 SYYVH 17 MINPSDGSTYYAQRFQP 11 GVVGATNEIDF crystal 2.60A 18.80% FAB 05-OCT-12 20121005 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 2G1 IN COMPLEX WITH A H2N2 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIRKYLN 7 DASNVKT 9 QQYDNLPIT 5 THVFT 17 GFIAIFGTSNYAQKFQG 11 GISGSYGWFDP crystal 3.20A 25.20% FAB 06-OCT-12 20121006 IMMUNE SYSTEM SHARK IGNAR VARIABLE DOMAIN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: SQUALUS ACANTHIAS; ORGANISM_COMMON: DOGFISH SHARK; ORGANISM_TAXID: 7797; EXPRESSION_SYSTEM: CHLOROCEBUS AETHIOPS; EXPRESSION_SYSTEM_COMMON: AFRICAN GREEN MONKEY; EXPRESSION_SYSTEM_TAXID: 9534; EXPRESSION_SYSTEM_CELL_LINE: COS-1 0 0 0 0 0 0 crystal 3.04A 23.90% NAR 08-OCT-12 20121008 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 2 IN COMPLEX WITH A 5,6 - DEHYDRO - KDO DISACCHARIDE WITH A 5,6 - DEHYDRO - KDO DISACCHARIDE ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYNLRT 5 DYYMS 19 FIRNKANGYTTEYSPSVKG 10 DHDGYYERFS crystal 1.65A 17.70% FAB 08-OCT-12 20121008 IMMUNE SYSTEM ANTI - HUMAN CYTOMEGALOVIRUS (HCMV) FAB KE5 ? ? ? HOMO SAPIENS 11 RASQSVGGYLT 7 DASNRAT 10 QQRGNWPPIT 5 NHGMH 17 VISYDGRHEHYADLVKG 16 EGLSRDNSGFTGLIDY crystal 1.70A 21.70% FAB 09-OCT-12 20121009 IMMUNE SYSTEM ANTI - HUMAN CYTOMEGALOVIRUS (HCMV) FAB KE5 WITH EPITOPE PEPTIDE AD - 2S1 MOLECULE: GLYCOPROTEIN B; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVGGYLT 7 DASNRAT 10 QQRGNWPPIT 5 NHGMH 17 VISYDGRHEHYADLVKG 16 EGLSRDNSGFTGLIDY crystal 1.60A 21.30% FAB 09-OCT-12 20121009 IMMUNE SYSTEM ANTI - STREPTOCOCCUS PNEUMONIAE 23F FAB 023.102 ? ? ? HOMO SAPIENS 11 RASQSVTNYLA 7 GASNRAT 11 QQRDNWPPDAT 5 RYGMH 17 VVSSDGRTTYYADSVKG 11 EGGDNKFSFDY crystal 1.90A 21.80% FAB 11-OCT-12 20121011 IMMUNE SYSTEM ANTI - STREPTOCOCCUS PNEUMONIAE 23F FAB 023.102 WITH BOUND RHAMNOSE. ? ? ? HOMO SAPIENS 7 RATNYLA 7 GASNRAT 11 QQRDNWPPDAT 5 RYGMH 17 VVSSDGRTTYYADSVKG 11 EGGDNKFSFDY crystal 2.00A 22.40% FAB 11-OCT-12 20121011 IMMUNE SYSTEM ANTI - STREPTOCOCCUS PNEUMONIAE 23F FAB 023.102 WITH BOUND RHAMNOSE - GALACTOSE ? ? ? HOMO SAPIENS 5 RAYLA 7 GASNRAT 11 QQRDNWPPDAT 5 RYGMH 17 VVSSDGRTTYYADSVKG 11 EGGDNKFSFDY crystal 2.30A 24.30% FAB 11-OCT-12 20121011 IMMUNE SYSTEM ANTI - STREPTOCOCCUS PNEUMONIAE 23F FAB 023.102 WITH BOUND L - RHAMNOSE - (1 - 2) - ALPHA - D - GALACTOSE - (3 - O) - PHOSPHATE - 2 - GLYCEROL ? ? ? HOMO SAPIENS 11 RASQSVTNYLA 7 GASNRAT 11 QQRDNWPPDAT 5 RYGMH 17 VVSSDGRTTYYADSVKG 11 EGGDNKFSFDY crystal 2.10A 24.90% FAB 11-OCT-12 20121011 PROTEIN FIBRIL / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMANISED 3D6 FAB BOUND TO AMYLOID BETA PEPTIDE MOLECULE: BETA - AMYLOID PROTEIN 40; SYNONYM: BETA - APP40; ENGINEERED: YES ? ? HOMO SAPIENS, MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 NYGMS 17 SIRSGGGRTYYSDNVKG 10 YDHYSGSSDY crystal 2.20A 17.40% FAB 12-OCT-12 20121012 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN GIPR ECD IN COMPLEX WITH GIPG013 FAB AT 3 - A RESOLUTION MOLECULE: GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; FRAGMENT: EXTRA - CELLULAR DOMAIN, UNP RESIDUES 24 - 138; SYNONYM: GIP - R, GLUCOSE - DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSNSNIGSNTVH 7 SNNQRPS 11 AAWDDSLNGVV 5 SYAIS 17 GIIPTFGTANYAQKFQG 10 GPIVGAPTDY crystal 3.00A 26.00% FAB 12-OCT-12 20121012 IMMUNE SYSTEM MEDITOPE - ENABLED TRASTUZUMAB MOLECULE: PROTEIN L FRAGMENT; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.00A 15.50% ? 12-OCT-12 20121012 IMMUNE SYSTEM STRUCTURE REVEALS FUNCTION OF THE DUAL VARIABLE DOMAIN IMMUNOGLOBULIN (DVD - IG) MOLECULE MOLECULE: INTERLEUKIN - 18; FRAGMENT: UNP RESIUDES 37 - 192; SYNONYM: IL - 18, IBOCTADEKIN, INTERFERON GAMMA - INDUCING FACTOR, IFN - GAMMA - INDUCING FACTOR, INTERLEUKIN - 1 GAMMA, IL - 1 GAMMA; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.10A 18.60% FAB 12-OCT-12 20121012 IMMUNE SYSTEM UCA FAB (UNBOUND) FROM CH65 - CH67 LINEAGE ? ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 11 QVWDSSSDHVV 5 GYYMH 17 WINPNSGGTNYAQKFQG 17 GGLEPRSVDYYYYGMDV crystal 2.50A 20.90% FAB 14-OCT-12 20121014 IMMUNE SYSTEM I2 FAB (UNBOUND) FROM CH65 - CH67 LINEAGE ? ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 11 QVWDSSSDHVV 5 DYYIH 17 WIHPNSGGTNYAQKFQG 17 GGLEPRSVDYYYYGMDV crystal 3.00A 22.40% FAB 14-OCT-12 20121014 IMMUNE SYSTEM CH67 FAB (UNBOUND) FROM THE CH65 - 67 LINEAGE ? ? ? HOMO SAPIENS 17 GGNNIGRKRVDWFQQKP 7 TTATLTI 15 VLGQPKAAPSVTLFP 5 DNYIH 17 WIHPNSGATKYAQKFEG 17 AGLEPRSVDYYFYGLDV crystal 3.60A 26.10% FAB 15-OCT-12 20121015 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA HEMAGGLUTININ IN COMPLEX WITH CH67 FAB MOLECULE: HEMAGGLUTININ HA1; FRAGMENT: UNP RESIDUES 65 - 276; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNNIGRKRVD 1 E 11 QVWDSDSDHVV 5 DNYIH 17 WIHPNSGATKYAQKFEG 17 AGLEPRSVDYYFYGLDV crystal 2.50A 18.80% FAB 15-OCT-12 20121015 IMMUNE SYSTEM TRASTUZUMAB FAB COMPLEXED WITH PROTEIN L AND PROTEIN A FRAGMENTS MOLECULE: PROTEIN L FRAGMENT; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.08A 16.40% FAB 15-OCT-12 20121015 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB C179 IN COMPLEX WITH A H2N2 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; ENGINEERED: YES; ? ? MUS MUSCULUS 11 LASQTIGTWLA 7 AATSLAD 9 QQLYSTPWT 5 DDYMT 19 FIRDRANGYTTEYSASVKG 11 PKGYFPYAMDY crystal 2.90A 23.10% FAB 17-OCT-12 20121017 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF RV144 - ELICITED ANTIBODY CH58 IN COMPLEX WITH V2 PEPTIDE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 160 - 178; ENGINEERED: YES ? ? HOMO SAPIENS 13 TRSSGSVASDYVQ 7 EDNQRPS 11 YCQSYDNSSWV 5 SYWIV 17 IIYPGDFDTKYSPSFQG 17 LGGRYYHDSSGYYYLDY crystal 1.69A 18.70% FAB 24-OCT-12 20121024 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF RV144 - ELICITED ANTIBODY CH59 IN COMPLEX WITH V2 PEPTIDE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 160 - 178; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDALPKNYAY 7 EDSKRPS 11 YSTDSSGNHRV 5 DGAMH 17 GISWNSNIIAYADSVKG 11 DSPRGELPLNY crystal 1.50A 17.20% FAB 24-OCT-12 20121024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RV144 - ELICITED ANTIBODY CH58 ? ? ? HOMO SAPIENS 13 TRSSGSVASDYVQ 7 EDNQRPS 11 YCQSYDNSSWV 5 SYWIV 17 IIYPGDFDTKYSPSFQG 10 LGGGYYYLDY crystal 2.40A 18.50% FAB 25-OCT-12 20121025 IMMUNE SYSTEM HEPATITUS C ENVELOPE GLYCOPROTEIN E2 FRAGMENT 412 - 423 WITH HUMANIZED AND AFFINITY - MATURED ANTIBODY MRCT10.V362 MOLECULE: E2 - PEPTIDE; FRAGMENT: UNP RESIDUES 50 - 62; ENGINEERED: YES ? ? HOMO SAPIENS 15 RASESVDGYGYSFLH 7 LASNLNS 9 QQNNVDPWT 5 SGYWN 16 YISYSGSTYYSLSLRS 10 ITTSTYAMDY crystal 1.53A 17.50% ? 29-OCT-12 20121029 IMMUNE SYSTEM HEPATITUS C ENVELOPE GLYCOPROTEIN E2 FRAGMENT 412 - 423 WITH HUMANIZED AND AFFINITY - MATURED ANTIBODY HU5B3.V3 MOLECULE: E2 - PEPTIDE; FRAGMENT: UNP RESIDUES 50 - 62; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASESVDNYGISFMN 7 SASNHAS 9 HQSKEAPYA 5 NYWIN 17 DIYPSDSFTNYNQNFKD 13 SSIYYGKDYVLDY crystal 2.60A 22.50% FAB 29-OCT-12 20121029 IMMUNE SYSTEM HUMAN TWEAK IN COMPLEX WITH THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY MOLECULE: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12; SYNONYM: APO3 LIGAND, TNF - RELATED WEAK INDUCER OF APOPTOSIS, TWEAK, TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12, MEMBRANE FORM, TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12, SECRETED FORM; ? ? ORYCTOLAGUS CUNICULUS 11 QASQNIYSNLA 7 TASYLAS 13 QTAYYNSRPDTVA 5 TYYMS 17 TVYVRQGTTYYASWLNG 11 GGYNYDDAFVI crystal 2.50A 18.80% FAB 31-OCT-12 20121031 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ECTODOMAIN 3 OF THE IL - 13 RECEPTOR ALPHA 1 IN COMPLEX WITH A HUMAN NEUTRALIZING MONOCLONAL ANTIBODY FRAGMENT MOLECULE: INTERLEUKIN - 13 RECEPTOR SUBUNIT ALPHA - 1; SYNONYM: IL - 13 RECEPTOR SUBUNIT ALPHA - 1, IL - 13R SUBUNIT ALPHA - 1, IL - 13R - ALPHA - 1, IL - 13RA1, CANCER / TESTIS ANTIGEN 19, CT19; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSISSSYLA 7 GASSRAT 5 QQYET 6 TSYWIG 17 GVIYPGDSYTRYSPSFQ 10 RMPNWGSFDY crystal 2.61A 19.80% FAB 07-NOV-12 20121107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ECTODOMAIN 3 OF THE IL - 13 RECEPTOR ALPHA1 IN COMPLEX WITH A HUMAN NEUTRALIZING MONOCLONAL ANTIBODY FRAGMENT WITH A HUMAN NEUTRALIZING MONOCLONAL ANTIBODY FRAGMENT ? ? HOMO SAPIENS 12 RASQSISSSYLA 7 GASSRAT 5 QQYET 5 SYWIG 17 VIYPGDSYTRYSPSFQG 9 MPNWGSFDY crystal 2.43A 17.80% FAB 07-NOV-12 20121107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 13D9 FAB ? ? ? MUS MUSCULUS 10 SVSSSVNYMH 7 DTSNLAS 9 FQGSGYPLT 5 NYRMH 19 VITVKSDIYGANYAESVKG 8 SRGRTLDY crystal 2.06A 21.70% FAB 09-NOV-12 20121109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 6B9 FAB ? ? ? MUS MUSCULUS 16 RSSQTIVHSNGNTYLE 7 KVSNRFP 9 FQASHDPPT 5 NYGMN 17 WIKTNTGEPTYAEDFKG 6 LRAVDY crystal 2.45A 20.10% FAB 09-NOV-12 20121109 IMMUNE SYSTEM NEUTRALIZING ANTIBODY MAB#8 IN COMPLEX WITH THE EPITOPE II OF HCV E2 ENVELOPE PROTEIN MOLECULE: E2 ENVELOP PROTEIN; FRAGMENT: EPITOPE II RESIDUES 430 - 446 ? ? MUS MUSCULUS 16 RSSQSLVHSDGNTYLE 7 KLSNRFS 9 FQGSHVPPT 5 TYAMS 17 TISSGGSYTYYPDNVKG 13 HPPTVVAGDAMDY crystal 2.85A 22.40% FAB 15-NOV-12 20121115 IMMUNE SYSTEM / HYDROLASE THE STRUCTURE OF THE CAMELID ANTIBODY CABHUL5 IN COMPLEX WITH HUMAN LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C; EC: 3.2.1.17; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 3 VMA 17 AIYTGDGFPYYADSVKG 19 KTGAFSYGSLWWMSRAYNH crystal 1.95A 18.90% HC-dimer 16-NOV-12 20121116 OXIDOREDUCTASE / IMMUNE SYSTEM NANOBODY CA1697 BINDING TO THE DHFR.FOLATE BINARY COMPLEX MOLECULE: DIHYDROFOLATE REDUCTASE; EC: 1.5.1.3; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAIG 17 AISWGGGLTVYGESVEG 18 SRISYRVWNTIPYNKLTL crystal 1.60A 15.50% HC-dimer 19-NOV-12 20121119 CYTOKINE, SIGNALING PROTEIN CRYSTAL STRUCTURE OF HUMAN PROLACTIN RECEPTOR COMPLEXED WITH FAB FRAGMENT MOLECULE: PROLACTIN RECEPTOR; FRAGMENT: EXTRACELLULAR DOMAIN (UNP RESIDUES 25 - 235); SYNONYM: PRL - R; ENGINEERED: YES ? ? MUS MUSCULUS 11 CRASQSVSSAV 7 YSASSLY 12 CQQYYSYYYPFT 5 SSSMH 17 YISPYYGSTSYADSVKG 16 SYGYVYWNAYSSGMDY crystal 3.24A 19.40% FAB 20-NOV-12 20121120 OXIDOREDUCTASE / IMMUNE SYSTEM R104A - CA1697 NANOBODY BINDING TO THE BINARY DHFR.FOLATE COMPLEX MOLECULE: DIHYDROFOLATE REDUCTASE; EC: 1.5.1.3; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAIG 17 AISWGGGLTVYGESVEG 18 SRISYAVWNTIPYNKLTL crystal 1.89A 17.90% HC-dimer 21-NOV-12 20121121 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE OUTER DOMAIN OF HIV - 1 GP120 IN COMPLEX WITH VRC - PG04 SPACE GROUP P3221 MOLECULE: OUTER DOMAIN OF HIV - 1 GP120 (KER2018 OD4.2.2); ENGINEERED: YES; ? ? HOMO SAPIENS 9 TAASYGHMT 7 ATSKRAS 5 QQLEF 6 RTELIH 18 WVKTVTGAVNFGSPDFRQ 14 QKFYTGGQGWYFDL crystal 3.00A 18.60% FAB 26-NOV-12 20121126 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE OUTER DOMAIN OF HIV - 1 GP120 IN COMPLEX WITH VRC - PG04 SPACE GROUP P21 MOLECULE: OUTER DOMAIN OF HIV - 1 GP120 (KER2018 OD4.2.2); ENGINEERED: YES; ? ? HOMO SAPIENS 9 TAASYGHMT 7 ATSKRAS 5 QQLEF 6 RTELIH 18 WVKTVTGAVNFGSPDFRQ 14 QKFYTGGQGWYFDL crystal 2.85A 25.30% FAB 26-NOV-12 20121126 IMMUNE SYSTEM / CYTOKINE LEBRIKIZUMAB FAB BOUND TO IL - 13 MOLECULE: INTERLEUKIN - 13; SYNONYM: IL - 13; ENGINEERED: YES ? ? HOMO SAPIENS 15 RASKSVDSYGNSFMH 7 LASNLES 9 QQNNEDPRT 5 AYSVN 16 MIWGDGKIVYNSALKS 10 DGYYPYAMDN crystal 1.90A 18.00% FAB 30-NOV-12 20121130 METAL TRANSPORT HUMAN TWO PORE DOMAIN K+ CHANNEL TRAAK (K2P4.1) - FAB COMPLEX STRUCTURE MOLECULE: POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; FRAGMENT: UNP RESIDUES 1 - 300; SYNONYM: TWIK - RELATED ARACHIDONIC ACID - STIMULATED POTASSIUM CHANNEL PROTEIN, TRAAK, TWO PORE POTASSIUM CHANNEL KT4.1, TWO PORE K (+) CHANNEL KT4.1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSNSPPT 5 GYIMN 17 LINPNTGYTTYNQKFKG 7 GNYVFDY crystal 2.75A 20.30% FAB 05-DEC-12 20121205 IMMUNE SYSTEM S.AUREUS A - HEMOLYSIN MONOMER IN COMPLEX WITH FAB MOLECULE: ALPHA - HEMOLYSIN; SYNONYM: ALPHA - HL, ALPHA - TOXIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQTISNNFVA 7 GASTRAT 9 QQYGSSPYT 5 NVAIN 17 GIIPGLDTPNYAQKFQG 16 EMEVSGRWRPTEAFEI crystal 3.36A 25.20% FAB 12-DEC-12 20121212 IMMUNE SYSTEM LOW MELTING TEMPERATURE ANTI - CHOLERA TOXIN LLAMA VHH DOMAIN ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IRAMG 16 SLTTTGTADYGDFVKG 15 DGRRFDGARWREYES crystal 2.09A 20.70% HC-dimer 12-DEC-12 20121212 OXIDOREDUCTASE / OXIDOREDUCTASE INHIBITOR OXIDOREDUCTASE FRAGMENT OF HUMAN QSOX1 IN COMPLEX WITH A FAB FRAGMENT FROM AN ANTI - HUMAN QSOX1 ANTIBODY MOLECULE: SULFHYDRYL OXIDASE 1; FRAGMENT: OXIDOREDUCTASE FRAGMENT, UNP RESIDUES 33 - 272; SYNONYM: HQSOX, QUIESCIN Q6; EC: 1.8.3.2; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPLT 5 GYGVN 16 MIWGDGRTDYKSALKS 10 DYYGSGSFAY crystal 2.70A 20.20% FAB 21-DEC-12 20121221 IMMUNE SYSTEM UNCROSSED FAB BINDING TO HUMAN ANGIOPOIETIN 2 MOLECULE: HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 11 QVWDSSSDHYV 5 GYYMH 17 WINPNSGGTNYAQKFQG 20 SPNPYYYDSSGYYYPGAFDI crystal 2.20A 20.00% FAB 03-JAN-13 20130103 IMMUNE SYSTEM CROSSFAB BINDING TO HUMAN ANGIOPOIETIN 2 MOLECULE: CROSSED HEAVY CHAIN (VH - CKAPPA); ENGINEERED: YES; KAPPA ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 11 QVWDSSSDHYV 5 GYYMH 17 WINPNSGGTNYAQKFQG 20 SPNPYYYDSSGYYYPGAFDI crystal 2.93A 23.90% FAB 03-JAN-13 20130103 HYDROLASE CRYSTAL STRUCTURE ANALYSIS OF FAB - BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) MOLECULE: INSULIN - DEGRADING ENZYME; SYNONYM: ABETA - DEGRADING PROTEASE, INSULIN PROTEASE, INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; ? ? MUS MUSCULUS 8 RAVSSAVA 7 STSSLYS 10 QQSSPSFLIT 5 SYSIH 17 SISSYYGSTSYADSVKG 20 DRVMYYWSFSKYGYPYGMDY crystal 3.35A 23.50% FAB 07-JAN-13 20130107 IMMUNE SYSTEM MEDITOPE - ENABLED TRASTUZUMAB IN COMPLEX WITH CQFDLSTRRLKC MOLECULE: MEDITOPE; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.95A 17.70% ? 07-JAN-13 20130107 VIRAL PROTEIN STRUCTURE OF PHAGE TP901 - 1 RBP (ORF49) IN COMPLEX WITH NANOBODY 11. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LACTOCOCCUS PHAGE TP901-1; ORGANISM_TAXID: 35345; GENE: BPP, ORF49; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21; EXPRESSION_SYSTEM_VECTOR_TYPE: PET20G; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21 0 0 0 0 0 0 crystal 2.40A 20.20% Nanobody 08-JAN-13 20130108 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB NATALIZUMAB MOLECULE: INTEGRIN ALPHA4 SUBUNIT; ENGINEERED: YES; ? ? HOMO SAPIENS 11 KTSQDINKYMA 7 YTSALQP 8 LQYDNLWT 5 DTYIH 17 RIDPANGYTKYDPKFQG 14 EGYYGNYGVYAMDY crystal 2.84A 23.90% FAB 15-JAN-13 20130115 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR POLY - GLUTAMINE ? ? ? MUS MUSCULUS 12 TLSRQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 TYGMN 17 WINTYSGVPTYADDFKG 10 RRSYSNYFDY crystal 1.50A 19.90% FAB 17-JAN-13 20130117 IMMUNE SYSTEM MONOMERIC FC ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 22.30% FC 31-JAN-13 20130131 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY 93F3 UNSTABLE VARIANT ? ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSYDLPT 5 DYGVS 16 VIWGGGSTYYNSALKS 4 PGDS crystal 2.58A 21.30% ? 02-FEB-13 20130202 IMMUNE SYSTEM THE COMPLEX OF HUMAN IGE - FC WITH TWO BOUND FAB FRAGMENTS MOLECULE: IG EPSILON CHAIN C REGION; ENGINEERED: YES; MUTATION: YES; ? IGE HOMO SAPIENS 13 CSGSSSNIGNNGV 7 YYDDLLP 12 CEAWDDSLDGVV 7 SNSAAWN 18 RTYYRSKWYNDYAVSMKS 15 DGEISYDYYYYGMDV crystal 2.91A 23.90% FAB 07-FEB-13 20130207 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC23 IN COMPLEX WITH HIV - 1 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGVGSDVA 7 GASTRAS 5 QQYET 5 DYVLQ 17 WIKPERGAVSYAPQFQG 12 GVRRDASWWLQF crystal 1.64A 16.50% ? 11-FEB-13 20130211 IMMUNE SYSTEM STRUCTURE OF AN OCTAPEPTIDE REPEAT OF THE PRION PROTEIN BOUND TO THE POM2 FAB ANTIBODY FRAGMENT MOLECULE: MAJOR PRION PROTEIN; SYNONYM: PRP, PRP27 - 30, PRP33 - 35C; ENGINEERED: YES ? ? MUS MUSCULUS 10 KASQVGTALA 7 WASTRHT 8 QQYSSYPT 5 NYLIE 17 VINPGSGDTNYNEKFKG 13 SGAAAPTYYAMDY crystal 2.30A 24.70% FAB 14-FEB-13 20130214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTI - HIV - 1 ANTIBODY CH103 MOLECULE: ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN OF CH103; ENGINEERED: YES; ? ? HOMO SAPIENS 8 SGASTNVC 7 ENYKRPS 10 QVWDSFSTFV 5 GTYWS 16 YIFHTGETNYSPSLKG 13 LPRGQLVNAYFRN crystal 1.65A 17.00% ? 18-FEB-13 20130218 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CH103 IN COMPLEX WITH HIV - 1 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP120 OF HIV - 1 CLADE C; ENGINEERED: YES; ? ? HOMO SAPIENS 8 SGASTNVC 7 ENYKRPS 10 QVWDSFSTFV 5 GTYWS 16 YIFHTGETNYSPSLKG 13 LPRGQLVNAYFRN crystal 3.15A 19.90% ? 18-FEB-13 20130218 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC06 IN COMPLEX WITH HIV - 1 GP120 CORE MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 10 RASQGGNSLN 7 DTSRRAS 5 QQFEF 5 DFSIH 17 WIKPMWGAVNYARQLQG 26 SADTADYFCVRRGSSCPHCGDFHFEH crystal 2.60A 25.00% ? 19-FEB-13 20130219 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF CHIMERIC GERM - LINE PRECURSOR OF NIH45 - 46 FAB IN COMPLEX WITH GP120 OF 93TH057 HIV - 1 MOLECULE: GP120; FRAGMENT: GP120 CORE; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 9 RTSQSGSLA 7 SGSTRAA 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 12 GKYCYYNWDFQH crystal 3.26A 22.90% FAB 25-FEB-13 20130225 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GERM - LINE PRECURSOR OF NIH45 - 46 FAB ? KAPPA ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 16 GKYCTARDYYNWDFQH crystal 1.65A 17.40% FAB 25-FEB-13 20130225 IMMUNE SYSTEM STRUCTURE OF PHOSPHOTYROSINE (PTYR) SCAFFOLD BOUND TO PTYR PEPTIDE MOLECULE: PHOSPHOPEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 TFRKF 17 WVASIVTGGRKTYYSDS 14 CTRGYSSTSYAMDY crystal 1.95A 16.50% FAB 28-FEB-13 20130228 IMMUNE SYSTEM APO STRUCTURE OF PHOSPHOTYROSINE (PYAB) SCAFFOLD ? ? ? HOMO SAPIENS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 KFGMS 17 SIVTGGRKTYYSDSVKG 11 GYSSTSYAMDY crystal 2.63A 19.00% FAB 28-FEB-13 20130228 IMMUNE SYSTEM STRUCTURE OF PHOSPHOSERINE (PSAB) SCAFFOLD BOUND TO PSER PEPTIDE MOLECULE: PHOSPHOPEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 KFGMS 17 SIATGGHTTYYSDSVKG 11 GYSSTSYAMDY crystal 1.75A 15.60% FAB 28-FEB-13 20130228 IMMUNE SYSTEM STRUCTURE OF PHOSPHOSERINE / THREONINE (PSTAB) SCAFFOLD BOUND TO PSER PEPTIDE MOLECULE: PHOSPHOPEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 KFGMS 18 SISTPRGSTTYYSDSVKG 11 GYSSTSYAMDY crystal 1.81A 16.30% FAB 28-FEB-13 20130228 IMMUNE SYSTEM STRUCTURE OF PHOSPHOSERINE / THREONINE (PSTAB) SCAFFOLD BOUND TO PTHR PEPTIDE MOLECULE: PHOSPHOPEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 RKFGM 18 ASISTPRGSTTYYSDSVK 12 RGYSSTSYAMDY crystal 1.55A 15.20% FAB 28-FEB-13 20130228 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RSV - NEUTRALIZING HUMAN ANTIBODY D25 MOLECULE: D25 ANTIGEN - BINDING FRAGMENT HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIVNYLN 7 VASNLET 9 QQYDNLPLT 5 NYIIN 17 GIIPVLGTVHYAPKFQG 17 ETALVVSTTYLPHYFDN crystal 1.60A 24.10% ? 04-MAR-13 20130304 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN STABILIZED IN THE PREFUSION CONFORMATION BY HUMAN ANTIBODY D25 MOLECULE: FUSION GLYCOPROTEIN F0; SYNONYM: PROTEIN F, FUSION GLYCOPROTEIN F2, FUSION GLYCOPROTEIN F1; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 QASQDIVNYLN 7 VASNLET 9 QQYDNLPLT 5 NYIIN 17 GIIPVLGTVHYAPKFQG 17 ETALVVSTTYLPHYFDN crystal 3.60A 21.60% ? 05-MAR-13 20130305 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR POLY - GLUTAMINE ? ? ? MUS MUSCULUS 12 TLSRQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 TYGMN 17 WINTYSGVPTYADDFKG 10 RRSDSNYFDY crystal 2.44A 24.10% FAB 07-MAR-13 20130307 VIRAL PROTEIN / IMMUNE SYSTEM RESTRICTING HIV - 1 PATHWAYS FOR ESCAPE USING RATIONALLY - DESIGNED ANTI - HIV - 1 ANTIBODIES MOLECULE: GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WLKPRWGAVNYARKFQG 16 GKYCTARDYYNWDFEH crystal 2.82A 19.50% ? 11-MAR-13 20130311 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A DESIGNED RESPIRATORY SYNCYTIAL VIRUS IMMUNOGEN IN COMPLEX WITH MOTAVIZUMAB MOLECULE: RSV_1ISEA DESIGNED SCAFFOLD; ENGINEERED: YES ? ? HOMO SAPIENS 10 SASSRVGYMH 7 DTSKLAS 9 FQGSGYPFT 7 TAGMSVG 16 DIWWDDKKHYNPSLKD 10 DMIFNFYFDV crystal 2.71A 19.40% FAB 12-MAR-13 20130312 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF PGT 135 FAB IN COMPLEX WITH GP120 CORE PROTEIN FROM HIV - 1 STRAIN JR - FL BOUND TO CD4 AND 17B FAB MOLECULE: GP120; FRAGMENT: CORE WITH MINI V3 LOOP; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQNINKNLA 7 ETYSKIA 9 QQYEEWPRT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 3.10A 24.10% FAB 13-MAR-13 20130313 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PGT 135 FAB ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.75A 20.90% FAB 13-MAR-13 20130313 IMMUNE SYSTEM AN ANTIDOTE FOR DABIGATRAN ? ? ? MUS MUSCULUS 16 KSSQSLLYTDGKTYLY 7 LVSKLDS 9 LQSTHFPHT 5 SYIVD 16 VIWAGGSTGYNSALRS 14 AAYYSYYNYDGFAY crystal 1.89A 17.70% FAB 14-MAR-13 20130314 IMMUNE SYSTEM / INHIBITOR AN ANTIDOTE FOR DABIGATRAN ? ? ? MUS MUSCULUS 16 KSSQSLLYTDGKTYLY 7 LVSKLDS 9 LQSTHFPHT 1 D 16 VIWAGGSTGYNSALRS 14 AAYYSYYNYDGFAY crystal 1.71A 16.80% FAB 14-MAR-13 20130314 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF RABBIT MAB R56 FAB IN COMPLEX WITH V3 CROWN OF HIV - 1 JR - FL GP120 MOLECULE: GP120; FRAGMENT: THIRD VARIABLE REGION (V3) CROWN (UNP RESIDUES 32 - 54); ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 13 QSSQNVYSNNNLA 7 DASKLAS 13 LGGYDCSSGDCAA 6 NNYDMC 18 CIETGSSDSAAYATWAKG 4 NFDL crystal 2.03A 18.30% FAB 16-MAR-13 20130316 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF RABBIT MAB R56 FAB IN COMPLEX WITH V3 CROWN OF HIV - 1 CONSENSUS A GP120 MOLECULE: GP120; FRAGMENT: THIRD VARIABLE REGION (V3) CROWN (UNP RESIDUES 30 - 52); ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 13 QSSQNVYSNNNLA 7 DASKLAS 13 LGGYDCSSGDCAA 6 NNYDMC 18 CIETGSSDSAAYATWAKG 4 NFDL crystal 2.50A 19.30% FAB 16-MAR-13 20130316 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF RABBIT MAB R20 FAB IN COMPLEX WITH V3 C - TERMINUS OF HIV - 1 CONSENSUS B GP120 MOLECULE: GP120; FRAGMENT: THIRD VARIABLE REGION (V3) C - TERMINUS (UNP RESIDUES 48 - 62); ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 11 QASETISNYLA 7 KASTLAS 12 QQGYSISDIDNS 6 NNYYMC 18 CIYGGGRDIVFYATWAKG 21 ENFDAVGVGGGTYSTDYYFDL crystal 2.60A 18.70% FAB 16-MAR-13 20130316 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RABBIT MAB R20 FAB ? ? ? ORYCTOLAGUS CUNICULUS 11 QASETISNYLA 7 KASTLAS 12 QQGYSISDIDNS 6 NNYYMC 18 CIYGGGRDIVFYATWAKG 21 ENFDAVGVGGGTYSTDYYFDL crystal 2.27A 18.60% FAB 16-MAR-13 20130316 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A PUTATIVE VRC01 GERMLINE PRECURSOR FAB ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 12 GKNCDYNWDFQH crystal 2.10A 17.70% FAB 19-MAR-13 20130319 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF THE GERMLINE - TARGETING HIV - 1 GP120 ENGINEERED OUTER DOMAIN EOD - GT6 IN COMPLEX WITH A PUTATIVE VRC01 GERMLINE PRECURSOR FAB MOLECULE: GERMLINE - TARGETING HIV - 1 GP120 ENGINEERED OUTER DOMAIN, EOD - GT6; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 12 GKNSDYNWDFQH crystal 2.40A 20.30% FAB 19-MAR-13 20130319 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 3BNC117 IN COMPLEX WITH HIV - 1 GP120 MOLECULE: HIV - 1 CLADE A STRAIN 93TH057 GP120 WITH LOOP D AND LOOPD V5 REPLACED FROM HIV STRAIN 3415V1; ENGINEERED: YES; ? ? HOMO SAPIENS 7 QANGYLN 7 DGSKLER 8 QVYEFVVP 5 DYFIH 19 WINPKTGQPNNPRQFQGRV 12 ARQRSDYWDFDV crystal 2.83A 20.30% ? 19-MAR-13 20130319 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 12A21 IN COMPLEX WITH HIV - 1 STRAIN 93TH057 GP120 MUTANT MOLECULE: HIV - 1 CLADE A / E STRAIN 73TH057 GP120 WITH MUTATION H375S; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 QAGQGIGSSLN 7 GASNLQR 5 AVFQW 5 NYILH 17 LIKPVFGAVNYARQFQG 13 DESGDDLKWHLHP crystal 2.90A 20.90% ? 19-MAR-13 20130319 SIGNALING PROTEIN STRUCTURE OF ACTIVE BETA - ARRESTIN1 BOUND TO A G PROTEIN - COUPLED RECEPTOR PHOSPHOPEPTIDE MOLECULE: VASOPRESSIN V2 RECEPTOR PHOSPHOPEPTIDE; FRAGMENT: UNP RESIDUES 343 - 371; ENGINEERED: YES ? ? MUS MUSCULUS 11 CRASQSVSSAV 7 YSASSLY 10 CQQYKYVPVT 5 SSSIH 17 SISSYYGYTYYADSVKG 11 SRQFWYSGLDY crystal 2.60A 20.30% FAB 20-MAR-13 20130320 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF NITRATE / NITRITE EXCHANGER NARK MOLECULE: NITRITE EXTRUSION PROTEIN 1; SYNONYM: NITRITE FACILITATOR 1; ENGINEERED: YES; KAPPA ? MUS MUSCULUS 11 QASQNITNYIV 7 YTSTLES 8 LQYNSLLT 5 DYGMN 17 WINTSNGYTTYGAAFKG 9 SWYNRAMDY crystal 2.60A 23.10% ? 21-MAR-13 20130321 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF NITRATE / NITRITE EXCHANGER NARK WITH NITRITE BOUND MOLECULE: NITRITE EXTRUSION PROTEIN 1; SYNONYM: NITRITE FACILITATOR 1; ENGINEERED: YES; KAPPA ? MUS MUSCULUS 11 QASQNITNYIV 7 YTSTLES 8 LQYNSLLT 5 DYGMN 17 WINTSNGYTTYGAAFKG 9 SWYNRAMDY crystal 2.80A 22.60% ? 21-MAR-13 20130321 IMMUNE SYSTEM THREE DIMENSIONAL STRUCTURE OF BROADLY NEUTRALIZING ANTI - HEPATITIS C VIRUS (HCV) GLYCOPROTEIN E2 ALPACA NANOBODY D03 MOLECULE: ANTI - HCV E2 ALPACA NANOBODY D03; ENGINEERED: YES ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 4 YAIG 17 CITNFDGGTYYADSVKS 16 DKGLCSWLRAKVTFGS crystal 1.76A 18.30% HC-dimer 26-MAR-13 20130326 PROTEIN BINDING IGM C2 - DOMAIN FROM MOUSE ? ? IGM MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGH-6; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 511693; EXPRESSION_SYSTEM_STRAIN: BL21; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET28A 0 0 0 0 0 0 crystal 1.30A 13.90% FC 26-MAR-13 20130326 PROTEIN BINDING IGM C4 - DOMAIN FROM MOUSE ? ? IGM MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGH-6; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 511693; EXPRESSION_SYSTEM_STRAIN: BL21; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET28A 0 0 0 0 0 0 crystal 2.00A 19.90% FC 26-MAR-13 20130326 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PGT121, A BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 11 GEKSLGSRAVQ 7 NNQDRPS 15 YYCHIWDSRVPTKWV 5 DSYWS 16 YVHKSGDTNYSPSLKS 24 TLHGRRIYGIVAFNEWFTYFYMDV crystal 2.80A 19.20% FAB 29-MAR-13 20130329 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PGT122, A BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 11 GEESLGSRSVI 7 NNNDRPS 15 YYCHIWDSRRPTNWV 5 DNYWS 16 YVHDSGDTNYNPSLKS 24 TKHGRRIYGVVAFKEWFTYFYMDV crystal 1.75A 20.00% FAB 29-MAR-13 20130329 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PGT123, A BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 11 GKESIGSRAVQ 7 NNQDRPA 15 YYCHIYDARGGTNWV 5 DAYWS 16 YVHHSGDTNYNPSLKR 24 ALHGKRIYGIVALGELFTYFYMDV crystal 2.50A 21.00% FAB 29-MAR-13 20130329 CYTOKINE RECEPTOR / IMMUNE SYSTEM CRYSTAL STRUCTURE OF RECEPTOR - FAB COMPLEX MOLECULE: INTERLEUKIN - 3 RECEPTOR SUBUNIT ALPHA; FRAGMENT: DOMAIN 2, DOMAIN 3, UNP RESIDUES 20 - 307; SYNONYM: IL - 3 RECEPTOR SUBUNIT ALPHA, IL - 3R SUBUNIT ALPHA, IL - 3R - ALPHA, IL - 3RA; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 17 ESSQSLLNSGNQKNYLT 7 WASTRES 9 QNDYSYPYT 5 DYYMK 17 DIIPSNGATFYNQKFKG 11 SHLLRASWFAY crystal 2.80A 18.80% FAB 03-APR-13 20130403 IMMUNE SYSTEM / VIRAL PROTEIN THREE DIMENSIONAL STRUCTURE OF BROADLY NEUTRALIZING HUMAN ANTI - HEPATITIS C VIRUS (HCV) GLYCOPROTEIN E2 FAB FRAGMENT HC84 - 1 MOLECULE: ENVELOPE GLYCOPROTEIN E2; FRAGMENT: RESIDUES 434 - 446 OF HCV STRAIN H77 POLYPROTEIN; SYNONYM: NS1, GP68, GP70, GENOME POLYPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 9 QVWDSSSVV 0 17 GFIPTFRTAMYAQGFQG 10 GPLSRGYYDY crystal 2.05A 20.00% FAB 03-APR-13 20130403 IMMUNE SYSTEM / VIRAL PROTEIN THREE DIMENSIONAL STRUCTURE OF BROADLY NEUTRALIZING HUMAN ANTI - HEPATITIS C VIRUS (HCV) GLYCOPROTEIN E2 FAB FRAGMENT HC84 - 27 MOLECULE: ENVELOPE GLYCOPROTEIN E2; FRAGMENT: RESIDUES 434 - 446 OF HCV STRAIN H77 POLYPROTEIN; SYNONYM: NS1, GP68, GP70, GENOME POLYPROTEIN; EC: 3.4.22. - , 3.4.21.98, 3.6.1.15, 3.6.4.13, 2.7.7.48; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDKLGDKYAS 7 QDNKRPS 9 QAWDSNTGV 5 NYVIT 17 GFIPTFRTAMYAQGFQG 10 GPLSRGYYDY crystal 2.22A 19.80% FAB 03-APR-13 20130403 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE AMYLOID - FORMING IMMUNOGLOBULIN AL - 103 CIS - PROLINE 95 MUTANT ? ? ? HOMO SAPIENS 11 CQASQDISNYL 7 YDASNLE 10 CQQYHNLPYT 0 N/A 0 N/A 0 N/A crystal 2.83A 20.30% LC-dimer 03-APR-13 20130403 IMMUNE SYSTEM STRUCTURE OF ANTI - UPAR FAB ATN - 658 ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPLT 5 SYYMH 17 EINPYNGGASYNQKIKG 10 SIYGHSVLDY crystal 1.60A 20.10% FAB 08-APR-13 20130408 IMMUNE SYSTEM STRUCTURE OF ANTI - UPAR FAB ATN - 658 IN COMPLEX WITH UPAR MOLECULE: VITRONECTIN; FRAGMENT: UNP RESIDUES 21 - 60; SYNONYM: VN, S - PROTEIN, SERUM - SPREADING FACTOR, V75, VITRONECTIN V65 SUBUNIT, VITRONECTIN V10 SUBUNIT, SOMATOMEDIN - B; ENGINEERED: YES; ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPLT 5 SYYMH 17 EINPYNGGASYNQKIKG 10 SIYGHSVLDY crystal 4.50A 22.00% FAB 08-APR-13 20130408 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFEBA - 175 F1 IN COMPLEX WITH R218 ANTIBODY FAB FRAGMENT MOLECULE: ERYTHROCYTE BINDING ANTIGEN 175; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RAGQDISNYLN 7 YTSRLHS 9 QQGSTFPWT 5 DNYMH 17 RIDPANGNTKYDPKFQG 12 HYDGYFLYYFEY crystal 2.45A 20.60% FAB 09-APR-13 20130409 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOVINE ANTIBODY BLV1H12 WITH ULTRALONG CDR H3 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTGGNTGYNPGLKS 26 VHQETKKYQSCPDGYRERSDCSNRPA crystal 1.85A 18.40% ? 10-APR-13 20130410 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOVINE ANTIBODY BLV5B8 WITH ULTRALONG CDR H3 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 2 VG 16 SIDTGGSTGYNPGLKS 26 VHQETRKTCSDGYIAVDSCGRGQSDG crystal 2.20A 20.40% ? 10-APR-13 20130410 IMMUNE SYSTEM IMMUNOGLOBULIN LAMBDA VARIABLE DOMAIN L5 (L89S) FLUOROGEN ACTIVATING PROTEIN ? LAMBDA ? HOMO SAPIENS 14 GSSTGAVTSGHYAN 7 ETDKKYS 9 SLSDVDGYL 0 N/A 0 N/A 0 N/A crystal 1.93A 19.50% LC-dimer 10-APR-13 20130410 IMMUNE SYSTEM / INHIBITOR IMMUNOGLOBULIN LAMBDA VARIABLE DOMAIN L5 (L89S) FLUOROGEN ACTIVATIONG PROTEIN IN COMPLEX WITH MALACHITE GREEN WITH MALACHITE GREEN LAMBDA ? HOMO SAPIENS 14 GSSTGAVTSGHYAN 7 ETDKKYS 9 SLSDVDGYL 0 N/A 0 N/A 0 N/A crystal 2.45A 19.60% LC-dimer 10-APR-13 20130410 TRANSFERASE / IMMUNE SYSTEM / GROWTH FACTOR CRYSTAL STRUCTURE OF ONARTUZUMAB FAB IN COMPLEX WITH MET AND HGF - BETA MOLECULE: HEPATOCYTE GROWTH FACTOR BETA CHAIN; FRAGMENT: SEMA AND PSI DOMAIN, UNP RESIDUES 39 - 564; SYNONYM: HGF RECEPTOR, HGF / SF RECEPTOR, PROTO - ONCOGENE C - MET, SCATTER FACTOR RECEPTOR, SF RECEPTOR, TYROSINE - PROTEIN KINASE MET; EC: 2.7.10.1; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSLLYTSSQKNYLA 7 WASTRES 9 QQYYAYPWT 5 SYWLH 17 MIDPSNSDTRFNPNFKD 10 YRSYVTPLDY crystal 2.80A 21.30% FAB 10-APR-13 20130410 IMMUNE SYSTEM GENERATION AND CHARACTERIZATION OF A UNIQUE REAGENT THAT RECOGNIZES A PANEL OF RECOMBINANT HUMAN MONOCLONAL ANTIBODY THERAPEUTICS IN THE PRESENCE OF ENDOGENOUS HUMAN IGG ? ? IGG HOMO SAPIENS 10 RASSSVSYLH 7 APSNLAS 9 QQWAFNPPT 5 SYNMH 17 AIYPGNGATSYNQKFKG 13 VVYYSASYWYFDV crystal 2.95A 22.20% FAB 17-APR-13 20130417 IMMUNE SYSTEM AN ANTIBODY AGAINST THE C - TERMINAL DOMAIN OF PCSK9 LOWERS LDL CHOLESTEROL LEVELS IN VIVO MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; FRAGMENT: UNP RESIDUES 153 - 692; SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1, NARC - 1, PROPROTEIN CONVERTASE 9, PC9, SUBTILISIN / KEXIN - LIKE PROTEASE PC9; EC: 3.4.21. -; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQGISSALA 7 DASSLES 9 QQFNSYLIT 5 SYDMH 16 AIGTAGDTYYPDSVKG 20 EGTYYHDSGSDNYYSYGMDV crystal 3.22A 17.00% FAB 18-APR-13 20130418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF KIT D4D5 FRAGMENT IN COMPLEX WITH ANTI - KIT ANTIBODY FAB19 MOLECULE: MAST / STEM CELL GROWTH FACTOR RECEPTOR KIT; SYNONYM: SCFR, PIEBALD TRAIT PROTEIN, PBT, PROTO - ONCOGENE C - KIT, TYROSINE - PROTEIN KINASE KIT, P145 C - KIT, V - KIT HARDY - ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 10 QQWAVHSLIT 5 SYSMH 17 SIYPYSGYTYYADSVKG 8 YVYHALDY crystal 2.40A 20.00% FAB 19-APR-13 20130419 IMMUNE SYSTEM CRYSTAL STRUCTURE OF KIT D4D5 FRAGMENT IN COMPLEX WITH ANTI - KIT ANTIBODIES FAB79D MOLECULE: MAST / STEM CELL GROWTH FACTOR RECEPTOR KIT; SYNONYM: SCFR, PIEBALD TRAIT PROTEIN, PBT, PROTO - ONCOGENE C - KIT, TYROSINE - PROTEIN KINASE KIT, P145 C - KIT, V - KIT HARDY - ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG; EC: 2.7.10.1; ENGINEERED: YES ? ? MUS MUSCULUS 13 RASQRGLRNVAVA 7 SASSLYS 10 QQWAVHSLIT 6 SVYMMH 17 ASIYPYSGYTYYADSVK 9 RYVYHALDY crystal 2.70A 24.80% FAB 19-APR-13 20130419 IMMUNE SYSTEM STRUCTURE OF RITUXIMAB FAB MOLECULE: RITUXIMAB LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS, MUS MUSCULUS 10 RASSSVSYIH 7 ATSNLAS 9 QQWTSNPPT 5 SYNMH 17 AIYPGNGDTSYNQKFKG 12 STYYGGDWYFNV crystal 2.48A 18.20% FAB 22-APR-13 20130422 IMMUNE SYSTEM STRUCTURE OF AN EARLY NATIVE - LIKE INTERMEDIATE OF BETA2 - MICROGLOBULIN AMYLOIDOSIS MOLECULE: BETA - 2 - MICROGLOBULIN; FRAGMENT: UNP RESIDUES 21 - 119; SYNONYM: BETA - 2 - MICROGLOBULIN FORM PI 5.3; ENGINEERED: YES ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 RYCMA 17 RINSGRDITYYADSVKG 19 DIPLRCRDIVAKGGDGFRY crystal 2.60A 22.80% HC-dimer 25-APR-13 20130425 IMMUNE SYSTEM TRIPLE HELIX BUNDLE OF GP41 COMPLEXED WITH FAB 8066 MOLECULE: GP41 HELIX; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNIPYEYAS 7 GDNNRPS 11 ASWDSMTVDGV 5 SYAFS 17 SIIPIFGTTNYAQKFQG 12 YFDTYNNYGFAN crystal 2.82A 21.70% FAB 01-MAY-13 20130501 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GP41 HELIX COMPLEXED WITH ANTIBODY 8062 MOLECULE: GP41 HELIX; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNIPYEYAS 7 GDNNRPS 11 ASWDSMTVDGV 5 SYAFS 17 SIIPLFGFVVYAQKFQG 12 YFDTYNNYGFAN crystal 2.92A 23.90% ? 01-MAY-13 20130501 IMMUNE SYSTEM PRIMITIVE TRICLINIC CRYSTAL FORM OF THE HUMAN IGE - FC (EPSILON) 3 - 4 BOUND TO ITS B CELL RECEPTOR DERCD23 ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCER2, CD23A, CLEC4J, FCE2, IGEBF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.20A 23.40% FC 01-MAY-13 20130501 IMMUNE SYSTEM CYSTAL STRUCTURE OF HUMAN FACTOR VIII C2 DOMAIN IN A TERNARY COMPLEX WITH MURINE INHBITORY ANTIBODIES 3E6 AND G99 MOLECULE: COAGULATION FACTOR VIII; FRAGMENT: C2 DOMAIN; SYNONYM: ANTIHEMOPHILIC FACTOR, AHF, PROCOAGULANT COMPONENT, FACTOR VIIIA HEAVY CHAIN, 200 KDA ISOFORM, FACTOR VIIIA HEAVY CHAIN, 92 KDA ISOFORM, FACTOR VIII B CHAIN, FACTOR VIIIA LIGHT CHAIN; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSTVSYMY 7 DTSNLAS 9 QHWSSYPLT 5 DYSLH 17 WINTETGDPAYADDFKG 7 EDDGLAS crystal 2.47A 19.00% FAB 01-MAY-13 20130501 TRANPORT PROTEIN, MEMBRANE PROTEIN STRUCTURE OF THE CLC - EC1 DELTANC CONSTRUCT IN THE ABSENCE OF HALIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: UNP RESIDUES 17 - 460; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.20A 22.40% FAB 03-MAY-13 20130503 TRANPORT PROTEIN, MEMBRANE PROTEIN STRUCTURE OF THE CLC - EC1 DELTANC CONSTRUCT IN 100MM FLUORIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: UNP RESIDUES 17 - 460; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.88A 22.20% FAB 03-MAY-13 20130503 TRANSPORT PROTEIN, MEMBRANE PROTEIN STRUCTURE OF THE CLC - EC1 DELTANC CONSTRUCT IN 100MM FLUORIDE AND 20MM BROMIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.03A 23.20% FAB 03-MAY-13 20130503 TRANSPORT PROTEIN STRUCTURE OF THE CLC - EC1 DELTANC CONSTRUCT IN 20MM FLUORIDE AND 20MM BROMIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.17A 23.40% FAB 05-MAY-13 20130505 TRANSPORT PROTEIN STRUCTURE OF CLC - EC1 DELTANC CONSTRUCT IN 20MM BROMIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: UNP RESIDUES 17 - 460; SYNONYM: CLC - EC1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.18A 23.70% FAB 05-MAY-13 20130505 TRANSPORT PROTEIN STRUCTURE OF THE E148Q MUTANT OF CLC - EC1 DELTANC CONSTRUCT IN 100MM FLUORIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: UNP RESIDUES 17 - 460; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.86A 21.20% FAB 05-MAY-13 20130505 TRANSPORT PROTEIN STRUCTURE OF THE E148A MUTANT OF CLC - EC1 DELTANC CONSTRUCT IN 100MM FLUORIDE AND 2MM BROMIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: CLC - EC1 DELTANC; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.00A 22.00% FAB 05-MAY-13 20130505 TRANSPORT PROTEIN STRUCTURE OF THE E148A MUTANT OF CLC - EC1 DELTANC CONSTRUCT IN 100MM FLUORIDE AND 20MM BROMIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: CLC - EC1 DELTANC, UNP RESIDUES 17 - 460; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.00A 22.20% FAB 05-MAY-13 20130505 TRANSPORT PROTEIN STRUCTURE OF THE E148A MUTANT OF CLC - EC1 DELTANC CONSTRUCT IN 20MM FLUORIDE AND 20MM BROMIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: CLC - EC1 DELTANC; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.02A 23.80% FAB 05-MAY-13 20130505 TRANSPORT PROTEIN STRUCTURE OF THE E148A MUTANT OF CLC - EC1 DELTANC CONSTRUCT IN 20MM BROMIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: CLC - EC1 DELTANC; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.18A 23.30% FAB 05-MAY-13 20130505 TRANPORT PROTEIN, MEMBRANE PROTEIN STRUCTURE OF THE E148A MUTANT OF CLC - EC1 DELTA NC CONSTRUCT IN 100MM FLUORIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: UNP RESIDUES 17 - 460; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.85A 25.10% FAB 06-MAY-13 20130506 MEMBRANE PROTEIN / PROTEIN BINDING PROBING THE N - TERMINAL BETA - SHEET CONVERSION IN THE CRYSTAL STRUCTURE OF THE FULL - LENGTH HUMAN PRION PROTEIN BOUND TO A NANOBODY MOLECULE: MAJOR PRION PROTEIN; SYNONYM: PRP, ASCR, PRP27 - 30, PRP33 - 35C; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYNMG 17 SITSSGDKSDYTDSVKG 15 GLGIYIIRARGGYDH crystal 1.50A 17.60% HC-dimer 08-MAY-13 20130508 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY 5 - 51 / O12 ? KAPPA ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPLT 5 SYWIG 17 IIYPGDSDTRYSPSFQG 10 YDGIYGELDF crystal 2.10A 17.30% FAB 08-MAY-13 20130508 IMMUNE SYSTEM STRUCTURE OF THE FAB FRAGMENT OF N62, A PROTECTIVE MONOCLONAL ANTIBODY TO THE NONREDUCING END OF FRANCISELLA TULARENSIS O - ANTIGEN MOLECULE: N62 LIGHT CHAIN; ? ? MUS MUSCULUS 10 SASSSVNYMH 7 TTSNLAS 8 HQWSSYPT 5 SGYWN 16 YINYSGNTFYNPSLKS 5 YRFNY crystal 2.59A 22.50% FAB 13-MAY-13 20130513 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 17A ANTIBODY CNTO3186 ? ? ? HOMO SAPIENS 11 RASQGISNWLN 7 AASSLQS 8 QQYSDDPT 5 SYAIS 17 SIIPWFGTTNYAQKFQG 8 DSEYYFDH crystal 1.92A 17.30% FAB 14-MAY-13 20130514 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 17A ANTIBODY CNTO7357 ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDVSTAVA 7 WASTRHT 9 QQHYSTPYT 5 DYAMH 17 VISTYSGDARFNQKFTG 8 EVRRSMDY crystal 2.45A 21.30% FAB 14-MAY-13 20130514 TRANSFERASE / IMMUNE SYSTEM NANOBODY / VHH DOMAIN 7D12 IN COMPLEX WITH DOMAIN III OF THE EXTRACELLULAR REGION OF EGFR, PH 6.0 MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: EXTRACELLULAR REGION DOMAIN III (UNP RESIDUES 335 - 538); SYNONYM: PROTO - ONCOGENE C - ERBB - 1, RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYGMG 17 GISWRGDSTGYADSVKG 15 AAGSAWYGTLYEYDY crystal 2.85A 21.50% HC-dimer 16-MAY-13 20130516 TRANSFERASE / IMMUNE SYSTEM NANOBODY / VHH DOMAIN 7D12 IN COMPLEX WITH DOMAIN III OF THE EXTRACELLULAR REGION OF EGFR, PH 3.5 MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: EXTRACELLULAR REGION DOMAIN III (UNP RESIDUES 335 - 538); SYNONYM: PROTO - ONCOGENE C - ERBB - 1, RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYGMG 17 GISWRGDSTGYADSVKG 15 AAGSAWYGTLYEYDY crystal 2.65A 21.00% HC-dimer 16-MAY-13 20130516 IMMUNE SYSTEM NANOBODY / VHH DOMAIN EGA1 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 17 AIRWSGGYTYYTDSVKG 21 TYLSSDYSRYALPQRPLDYDY crystal 1.55A 20.00% HC-dimer 16-MAY-13 20130516 TRANSFERASE / IMMUNE SYSTEM NANOBODY / VHH DOMAIN EGA1 IN COMPLEX WITH THE EXTRACELLULAR REGION OF EGFR MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: EXTRACELLULAR REGION (UNP RESIDUES 25 - 642); SYNONYM: PROTO - ONCOGENE C - ERBB - 1, RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? LAMA GLAMA 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 SYAMG 17 AIRWSGGYTYYTDSVKG 21 TYLSSDYSRYALPQRPLDYDY crystal 3.05A 22.40% FAB 16-MAY-13 20130516 TRANSFERASE / IMMUNE SYSTEM NANOBODY / VHH DOMAIN 9G8 IN COMPLEX WITH THE EXTRACELLULAR REGION OF EGFR MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: EXTRACELLULAR REGION (UNP RESIDUES 25 - 642); SYNONYM: PROTO - ONCOGENE C - ERBB - 1, RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? LAMA GLAMA 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 SYAMG 17 AINWSSGSTYYADSVKG 18 GYQINSGNYNFKDYEYDY crystal 2.82A 21.70% FAB 16-MAY-13 20130516 IMMUNE SYSTEM FAB FRAGMENT OF HIV VACCINE - ELICITED CD4BS - DIRECTED ANTIBODY, GE136, FROM NON - HUMAN PRIMATE ? ? ? MACACA MULATTA 14 TLSSGFTVGRYSIF 7 YFSDSSQ 15 EADYHCAIWHSGAWV 5 TNDWS 17 GISGSSGDTDYNPALKS 16 EGIVLVNLAVKNWFDV crystal 2.00A 21.50% FAB 20-MAY-13 20130520 IMMUNE SYSTEM FAB FRAGMENT OF HIV VACCINE - ELICITED CD4BS - DIRECTED ANTIBODY, GE148, FROM NON - HUMAN PRIMATE ? ? ? MACACA MULATTA 14 TLSSGINVGSYSIF 7 YYSDSSK 15 EADYYCAIWHNFACV 6 GGYGWG 17 SIYSSSGSTDYNPSLKS 16 VQNIVVVFTIKEFFEL crystal 1.80A 16.60% FAB 20-MAY-13 20130520 IMMUNE SYSTEM ROLE OF THE HINGE AND C - GAMMA - 2 / C - GAMMA - 3 INTERFACE IN IMMUNOGLOBIN G1 FC DOMAIN MOTIONS: IMPLICATIONS FOR FC ENGINEERING ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; TISSUE: SERUM 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 21.50% FC 21-MAY-13 20130521 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF RICIN - A CHAIN IN COMPLEX WITH THE ANTIBODY 6C2 MOLECULE: RICIN; SYNONYM: RICIN A CHAIN, RRNA N - GLYCOSIDASE; EC: 3.2.2.22; ENGINEERED: YES; ? ? MUS MUSCULUS 10 RASKSVSYMH 7 LGSNLES 9 QHKREYPPT 5 SYWIN 17 NIYPGSGRTNYDEKFKN 12 WVYGNFDSALDY crystal 2.79A 24.10% FAB 21-MAY-13 20130521 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - EMMPRIN ANTIBODY 4A5 FAB IN TRIGONAL FORM ? ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSLLYSSNQKNYLA 7 WASTRES 8 QQYYSYPT 5 DYYMN 17 GINPNNGGTSYNQKFKG 11 NDGYRGYAMDY crystal 2.70A 23.30% FAB 22-MAY-13 20130522 IMMUNE SYSTEM SCFV GC1009 IN COMPLEX WITH TGF - BETA1. MOLECULE: TRANSFORMING GROWTH FACTOR BETA - 1; FRAGMENT: UNP RESIDUES 279 - 390; SYNONYM: TGF - BETA - 1, LATENCY - ASSOCIATED PEPTIDE, LAP; ENGINEERED: YES; ? ? HOMO SAPIENS 12 CRASQSLGSSYL 7 YGASSRA 10 CQQYADSPIT 5 SNVIS 17 GVIPIVDIANYAQRFKG 11 TLGLVLDAMDY crystal 3.00A 23.30% FV 22-MAY-13 20130522 IMMUNE SYSTEM 2H2 FAB FRAGMENT OF IMMATURE DENGUE VIRUS MOLECULE: IG HEAVY CHAIN V REGION MOPC 21, IGH PROTEIN; ENGINEERED: YES; KAPPA ? MUS MUSCULUS 11 KASENVVTYVS 7 GASNRYT 9 GQGYSYPYT 5 SFGMH 17 YISSGSSTLHYADTVKG 11 WGNYPHYAMDY crystal 2.31A 18.20% FAB 22-MAY-13 20130522 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 39.29 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ A / PERTH / 16 / 2009 (H3N2) MOLECULE: HEMAGGLUTININ; FRAGMENT: EXTRACELLULAR HA0 FRAGMENT; ENGINEERED: YES; ? IGG HOMO SAPIENS 11 RASQVISHNLA 7 GASTRAS 11 QHYSNWPPRLT 2 VH 17 LISYDGANQYYADSVKG 16 PGPVFGIFPPWSYFDN crystal 3.10A 20.50% FAB 22-MAY-13 20130522 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TGFB2 IN COMPLEX WITH GC2008. MOLECULE: TRANSFORMING GROWTH FACTOR BETA - 2; FRAGMENT: UNP RESIDUES 303 - 414; SYNONYM: TGF - BETA - 2, BSC - 1 CELL GROWTH INHIBITOR, CETERMIN, GLIOBLASTOMA - DERIVED T - CELL SUPPRESSOR FACTOR, G - TSF, POLYERGIN, LATENCY - ASSOCIATED PEPTIDE, LAP; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSLGSSYLA 7 GASSRAP 9 QQYADSPIT 5 SNVIS 17 GVIPIVDIANYAQRFKG 11 TLGLVLDAMDY crystal 2.83A 18.30% FAB 28-MAY-13 20130528 IMMUNE SYSTEM HUMANIZED HP1 / 2 FAB MUHP1 / 2 CDRS + HUMAN KAPPA B3 GERMLINE VL FRAMEWORK; KAPPA IGG1 HOMO SAPIENS 11 KASQSVTNDVA 7 YASNRYT 9 QQDYSSPYT 5 DVYMH 17 RIDPASGDTKYDPKFQV 12 GMWVSTGYALDF crystal 2.97A 21.00% FAB 28-MAY-13 20130528 IMMUNE SYSTEM / RNA CRYSTAL STRUCTURE OF AN RNA APTAMER IN COMPLEX WITH FLUOROPHORE AND FAB MOLECULE: RNA (84 - MER); ENGINEERED: YES; OTHER_DETAILS: SPINACH RNA APTAMER ? ? MUS MUSCULUS 11 CRASQSVSSAV 7 YSASSLY 10 CQQSYSFPST 5 YSSIH 17 SISPYSGSTYYADSVKG 13 QGYRRRSGRGFDY crystal 2.19A 18.00% FAB 29-MAY-13 20130529 IMMUNE SYSTEM / RNA CRYSTAL STRUCTURE OF AN RNA APTAMER IN COMPLEX WITH FAB MOLECULE: RNA (84 - MER); ENGINEERED: YES; OTHER_DETAILS: SPINACH RNA APTAMER ? ? MUS MUSCULUS 11 CRASQSVSSAV 7 YSASSLY 10 CQQSYSFPST 5 YSSIH 17 SISPYSGSTYYADSVKG 13 QGYRRRSGRGFDY crystal 2.40A 18.80% FAB 29-MAY-13 20130529 IMMUNE SYSTEM BENCE - JONES IMMUNOGLOBULIN REI VARIABLE PORTION WITH SEVEN POINT MUTATIONS ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 11 RASQDIIKYLA 7 EASNLQA 9 QQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 1.68A 21.30% LC-dimer 03-JUN-13 20130603 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FC - FRAGMENT OF HUMAN IGG2 - SIGMA ANTIBODY ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL: HEK 293E 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.92A 20.10% FC 07-JUN-13 20130607 VIRAL PROTEIN, IMMUNE SYSTEM CRYSTAL STRUCTURE OF DENV1 - E106 FAB BOUND TO DENV - 1 ENVELOPE PROTEIN DIII MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III (UNP RESIDUES 293 - 399); ENGINEERED: YES; KAPPA IGG2 MUS MUSCULUS 11 ITSTDIDDDMN 7 EGNTLRP 9 LQSDNLPLT 5 GYYIH 17 EINPRTGDTTYNQKFKA 8 RINWALDY crystal 2.45A 19.20% FAB 11-JUN-13 20130611 VIRAL PROTEIN / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 YU2 ENVELOPE GP120 GLYCOPROTEIN IN COMPLEX WITH CD4 - MIMETIC MINIPROTEIN, M48U1, AND LLAMA SINGLE - DOMAIN, BROADLY NEUTRALIZING, CO - RECEPTOR BINDING SITE ANTIBODY, JM4 MOLECULE: HIV - 1 YU2 GP120 ENVELOPE GLYCOPROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YYSIG 17 CISDSDGRTYYADSVKG 15 DCTVDPSLLYVMDYY crystal 2.14A 18.80% HC-dimer 20-JUN-13 20130620 IMMUNE SYSTEM CRYSTAL STRUCTURES OF A THERAPEUTIC SINGLE CHAIN ANTIBODY IN THE FREE FORM AND IN COMPLEX WITH AMPHETAMINE AND 4 - HYDROXYMETHAMPHETAMINE MOLECULE: SINGLE HEAVY CHAIN VARIABLE FRAGMENT; FRAGMENT: HEAVY CHAIN; ENGINEERED: YES; ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS; EXPRESSION_SYSTEM_COMMON: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: KM71H; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPICZ-ALPHA; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS; EXPRESSION_SYSTEM_COMMON: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: KM71H; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPICZ-ALPHA 12 CSASSSVSSSHL 7 YSTSNLA 10 CHQWSSFPFT 0 N/A 0 N/A 0 N/A crystal 2.80A 21.00% LC-dimer 20-JUN-13 20130620 IMMUNE SYSTEM CRYSTAL STRUCTURES OF A THERAPEUTIC SINGLE CHAIN ANTIBODY IN THE FREE FORM AND IN COMPLEX WITH AMPHETAMINE AND 4 - HYDROXYMETHAMPHETAMINE MOLECULE: SINGLE HEAVY CHAIN VARIABLE FRAGMENT; FRAGMENT: HEAVY CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 KVTLTCSASSSVSSSH 7 PKLWIYS 15 AASYFCHQWSSFPFT 5 SGYWS 16 YISYRGSTYYNPSLKS 10 FDSDDYAMEY crystal 2.38A 21.90% FV 20-JUN-13 20130620 IMMUNE SYSTEM CRYSTAL STRUCTURES OF A THERAPEUTIC SINGLE CHAIN ANTIBODY IN THE FREE FORM AND IN COMPLEX WITH AMPHETAMINE AND 4 - HYDROXYMETHAMPHETAMINE MOLECULE: SINGLE HEAVY CHAIN VARIABLE FRAGMENT; FRAGMENT: HEAVY CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 15 VTLTCSASSSVSSSH 7 KLWIYST 14 ASYFCHQWSSFPFT 5 SGYWS 16 YISYRGSTYYNPSLKS 10 FDSDDYAMEY crystal 2.33A 16.40% FV 20-JUN-13 20130620 TRANSPORT PROTEIN, MEMBRANE PROTEIN STRUCTURE OF KCSA WITH R122A MUTATION MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL, SKC1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.75A 16.90% FAB 20-JUN-13 20130620 IMMUNE SYSTEM ANTI CANINE CD28 ANTIBODY, 1C6 ? ? ? MUS MUSCULUS 17 CRSTKSLLHSNGNTYLY 7 YYMSNLA 10 CMQSLEYPYT 5 NYGMT 17 WINTYTGRPTYADDFKG 5 LGEDF crystal 1.90A 18.20% ? 21-JUN-13 20130621 TRANSPORT PROTEIN, MEMBRANE PROTEIN STRUCTURE OF KCSA WITH E118A MUTATION MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL, SKC1; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.75A 18.50% FAB 23-JUN-13 20130623 MEMBRANE PROTEIN / HYDROLASE STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO BI167107 AND AN ENGINEERED NANOBODY MOLECULE: LYSOZYME, BETA - 2 ADRENERGIC RECEPTOR; FRAGMENT: UNP RESIDUES 29 - 348 WITH A DELETION OF RESIDUES 235 - 263; SYNONYM: ENDOLYSIN, LYSIS PROTEIN, MURAMIDASE, BETA - 2 ADRENORECEPTOR, BETA - 2 ADRENOCEPTOR; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 2.79A 22.80% HC-dimer 24-JUN-13 20130624 MEMBRANE PROTEIN / HYDROLASE STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO HYDROXYBENZYLISOPROTERENOL AND AN ENGINEERED NANOBODY MOLECULE: LYSOZYME, BETA - 2 ADRENERGIC RECEPTOR; SYNONYM: ENDOLYSIN, LYSIS PROTEIN, MURAMIDASE, BETA - 2 ADRENORECEPTOR, BETA - 2 ADRENOCEPTOR; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 3.10A 23.00% HC-dimer 24-JUN-13 20130624 MEMBRANE PROTEIN / HYDROLASE STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO ADRENALINE AND AN ENGINEERED NANOBODY MOLECULE: LYSOZYME, BETA - 2 ADRENERGIC RECEPTOR; SYNONYM: ENDOLYSIN, LYSIS PROTEIN, MURAMIDASE, BETA - 2 ADRENORECEPTOR, BETA - 2 ADRENOCEPTOR; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 3.20A 22.40% HC-dimer 24-JUN-13 20130624 TRANSFERASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HER3 FAB RG7116 IN COMPLEX WITH THE EXTRACELLULAR DOMAINS OF HUMAN HER3 (ERBB3) MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 3; FRAGMENT: UNP RESIDUES 20 - 631; SYNONYM: HER3 (ERBB3) EXTRACELLULAR DOMAINS, PROTO - ONCOGENE - LIKE PROTEIN C - ERBB - 3, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER3; EC: 2.7.10.1; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSVLNSGNQKNYLT 7 WASTRES 9 QSDYSYPYT 5 SSYIS 17 WIYAGTGSPSYNQKLQG 11 HRDYYSNSLTY crystal 2.64A 23.00% FAB 26-JUN-13 20130626 IMMUNE SYSTEM UNLIGANDED CRYSTAL STRUCTURE OF MAB7 ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPWT 5 SGFWN 16 YIGFSGSTYYNPSLKS 9 VDNSAALDY crystal 2.02A 18.70% FAB 26-JUN-13 20130626 IMMUNE SYSTEM INHIBITORY MECHANISM OF AN ALLOSTERIC ANTIBODY TARGETING THE GLUCAGON RECEPTOR MOLECULE: GLUCAGON RECEPTOR; FRAGMENT: GCGR ECD (UNP RESIDUES 29 - 123); SYNONYM: GL - R; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQGIRNDLG 7 AASSLES 9 LQHNSNPLT 5 SYGMH 17 VMWYDGSNKDYVDSVKG 19 EKDHYDILTGYNYYYGLDV crystal 2.73A 21.20% FAB 26-JUN-13 20130626 HYDROLASE / IMMUNE SYSTEM RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH1) MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 36 - 296; SYNONYM: RICIN A CHAIN, RRNA N - GLYCOSIDASE; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 HYAIG 17 CNRGEYGSTVYVDSVKG 8 GCYSWRGP crystal 2.40A 22.80% HC-dimer 28-JUN-13 20130628 HYDROLASE / IMMUNE SYSTEM RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH3) MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 40 - 294; SYNONYM: RICIN A CHAIN, RRNA N - GLYCOSIDASE; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 IYRTC 16 AITSGGNTYYADSVKG 11 DEAGIGGFNDY crystal 1.65A 18.10% HC-dimer 28-JUN-13 20130628 HYDROLASE / IMMUNE SYSTEM RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH4) MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 39 - 301; SYNONYM: RICIN A CHAIN, RRNA N - GLYCOSIDASE; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 RNAMA 17 SINWTGSGTYYLDSVKG 20 STVFAEITGLAGYQSGSYDY crystal 2.70A 20.20% HC-dimer 28-JUN-13 20130628 HYDROLASE / IMMUNE SYSTEM RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH5) MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 39 - 297; SYNONYM: RICIN A CHAIN, RRNA N - GLYCOSIDASE; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 FETMG 16 TITNEGSSNYADSVKG 13 TFGSRWPYAHSDH crystal 1.80A 19.80% HC-dimer 01-JUL-13 20130701 HYDROLASE / IMMUNE SYSTEM RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH8) MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 39 - 298; SYNONYM: RICIN A CHAIN, RRNA N - GLYCOSIDASE; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 RNAMG 17 AINWSASSTYYRDSVKG 20 SSVYAEMPYADSVKATSYNY crystal 2.30A 19.30% HC-dimer 01-JUL-13 20130701 IMMUNE SYSTEM STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CSF - 1 RECEPTOR IN COMPLEX WITH THE FAB FRAGMENT OF RG7155 MOLECULE: MACROPHAGE COLONY - STIMULATING FACTOR 1 RECEPTOR; FRAGMENT: ECTODOMAIN, UNP RESIDUES 2 - 512; SYNONYM: CSF - 1 RECEPTOR, CSF - 1 - R, CSF - 1R, M - CSF - R, PROTO - ONCOGENE C - FMS; EC: 2.7.10.1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASEDVNTYVS 7 AASNRYT 8 QQSFSYPT 5 SYDIS 16 VIWTDGGTNYAQKLQG 8 DQRLYFDV crystal 2.60A 18.90% FAB 03-JUL-13 20130703 IMMUNE SYSTEM AN ANTIBODY AGAINST THE C - TERMINAL DOMAIN OF PCSK9 LOWERS LDL CHOLESTEROL LEVELS IN VIVO ? ? ? HOMO SAPIENS 11 RASQGISSALA 7 DASSLES 9 QQFNSYLIT 5 SYDMH 16 AIGTAGDTYYPDSVKG 20 EGTYYHDSGSDNYYSYGMDV crystal 2.20A 17.50% FAB 07-JUL-13 20130707 IMMUNE SYSTEM HUMANIZED ANTIBODY 4B12 FAB COMPLEXED WITH A CEMX SEGMENT MOLECULE: CEMX SEGMENT; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPPT 6 SDYAWN 16 SISYSGITGYNPSLKS 8 MGYDGLAY crystal 1.92A 18.20% FAB 09-JUL-13 20130709 IMMUNE SYSTEM STRUCTURE OF WILD - TYPE IGG1 ANTIBODY HEAVY CHAIN CONSTANT DOMAIN 1 AND LIGHT CHAIN LAMBDA CONSTANT DOMAIN (IGG1 CH1:CLAMBDA) AT 1.19A ? LAMBDA IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 511693; EXPRESSION_SYSTEM_STRAIN: CODONPLUS BL21(DE3); MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGLC2; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 511693 0 0 0 0 0 0 crystal 1.19A 14.60% CH1/CL 09-JUL-13 20130709 IMMUNE SYSTEM STRUCTURE OF REDESIGNED IGG1 FIRST CONSTANT AND LAMBDA DOMAINS (CH1:CLAMBDA CONSTANT REDESIGN 1, CRD1) AT 1.75A ? LAMBDA IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGLC2; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.75A 17.90% CH1/CL 09-JUL-13 20130709 IMMUNE SYSTEM STRUCTURE OF REDESIGNED IGG1 FIRST CONSTANT AND LAMBDA DOMAINS (CH1:CLAMBDA CONSTANT REDESIGN 2 BETA, CRD2B) AT 1.42A ? LAMBDA IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686G11190; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGL@; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.42A 18.90% CH1/CL 09-JUL-13 20130709 IMMUNE SYSTEM STRUCTURE OF PERTUZUMAB FAB WITH LIGHT CHAIN CLAMBDA AT 2.16A MOLECULE: LIGHT CHAIN CLAMBDA; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQRFKG 10 NLGPSFYFDY crystal 2.16A 22.50% FAB 09-JUL-13 20130709 IMMUNE SYSTEM THE STRUCTURE OF THE UNBOUND FORM OF ANTI - HIV ANTIBODY 4E10 FV ? ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.39A 21.70% FV 09-JUL-13 20130709 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PERTUZUMAB CLAMBDA FAB WITH VARIABLE DOMAIN REDESIGN (VRD2) AT 1.95A MOLECULE: LIGHT CHAIN CLAMBDA; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQRFKG 10 NLGPSFYFDY crystal 1.95A 21.20% FAB 09-JUL-13 20130709 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PERTUZUMAB CLAMBDA FAB WITH VARIABLE AND CONSTANT DOMAIN REDESIGNS (VRD2 AND CRD2) AT 1.6A MOLECULE: LIGHT CHAIN CLAMBDA; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQEFKG 10 NLGPSFYFDY crystal 1.60A 19.90% FAB 09-JUL-13 20130709 CELL ADHESION / IMMUNE SYSTEM DEVELOPMENT AND PRECLINICAL CHARACTERIZATION OF A HUMANIZED ANTIBODY TARGETING CXCL12 MOLECULE: STROMAL CELL - DERIVED FACTOR 1; SYNONYM: SDF - 1, HSDF - 1, C - X - C MOTIF CHEMOKINE 12, INTERCRINE REDUCED IN HEPATOMAS, IRH, HIRH, PRE - B CELL GROWTH - STIMULATING FACTOR, PBSF, SDF - 1 - BETA (3 - 72) , SDF - 1 - ALPHA (3 - 67); ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESISYSLS 7 NAVKLES 9 KQYWNTPFT 5 VYSVH 16 ALWGSGGTEYNSNLKS 12 DQGLNYGSLFDY crystal 2.77A 25.50% ? 10-JUL-13 20130710 MEMBRANE PROTEIN, TRANPORT PROTEIN STRUCTURE OF THE E148Q MUTANT OF CLC - EC1 DELTANC CONSTRUCT IN THE ABSENCE OF HALIDE MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; FRAGMENT: CLC - EC1 DELTANC; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 2.98A 21.20% FAB 13-JUL-13 20130713 IMMUNE SYSTEM STRUCTURE OF MURINE IGG2B A2C7 - FAB IN COMPLEX WITH VACCINIA ANTIGEN A33R AT THE RESOLUTION OF 2.3 ANGSTROMS MOLECULE: A33R; FRAGMENT: ECTODOMAIN (UNP RESIDUES 89 - 185); SYNONYM: EEV GLYCOPROTEIN, EEV MEMBRANE GLYCOPROTEIN, EEV MEMBRANE PHOSPHOGLYCOPROTEIN, VACV - DUKE - 164, VACV152; ENGINEERED: YES; MUTATION: YES; ? IGG2 MUS MUSCULUS 16 RSSQSLIHTNGNTYLH 7 KVSNRFS 10 SQSTHIPPWT 5 DYYIY 17 YISNSGGNTYYSDAVKG 8 QWGGAMDY crystal 2.30A 19.90% FAB 17-JUL-13 20130717 IMMUNE SYSTEM ANTI CMV FAB FRAGMENT MOLECULE: MSL - 109 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLLHTNGYNYLD 7 LASNRAS 9 MQALQIPRT 5 PYSVF 17 SINSDSTYKYYADSVKG 19 DRSYYAFSSLSDYYYGLDV crystal 1.65A 18.80% FAB 19-JUL-13 20130719 IMMUNE SYSTEM ONTOGENY OF RECOGNITION SPECIFICITY AND FUNCTIONALITY FOR THE ANTI - HIV ANTIBODY 4E10 MOLECULE: GEP 1 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 CRASQSVSSSYL 7 YGASSRA 10 CQQYGSSPST 0 17 GIIPIFGTANYAQKFQG 14 EGGWLGKPIGAFAY crystal 1.89A 19.00% FV 20-JUL-13 20130720 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC - CH31 IN COMPLEX WITH HIV - 1 CLADE A / E GP120 93TH057 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; ORGANISM_TAXID: 11676; STRAIN: 93TH057; GENE: ENV; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.15A 18.20% FC 23-JUL-13 20130723 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC - CH31 IN COMPLEX WITH HIV - 1 CLADE A / E GP120 93TH057 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN 3415_V1_C1 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; ORGANISM_TAXID: 11676; STRAIN: 93TH057; GENE: ENV; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.25A 19.40% FC 23-JUL-13 20130723 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC - CH31 IN COMPLEX WITH HIV - 1 CLADE A / E STRAN 93TH057 GP120 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN KER_2018_11 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; ORGANISM_TAXID: 11676; STRAIN: 93TH057; GENE: ENV; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293F; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PVRC8400 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.28A 19.80% FC 23-JUL-13 20130723 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV - 1 CLADE A STRAIN KER_2018_11 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 DCTLN 17 WLKPRGGAVNYARPLQG 12 GKNCDYNWDFEH crystal 2.59A 19.50% ? 23-JUL-13 20130723 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV - 1 CLADE C STRAIN ZM176.66 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP120 OF HIV - 1 CLADE C; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 DCTLN 17 WLKPRGGAVNYARPLQG 12 GKNCDYNWDFEH crystal 2.55A 19.30% ? 23-JUL-13 20130723 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC - PG20 IN COMPLEX WITH HIV - 1 CLADE A / E 93TH057 GP120 MOLECULE: HIV - 1 CLADE A / E STRAIN 93TH057 GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 8 TGASTSVA 7 DGNKRPS 5 NAFEF 5 DYFIH 17 WMNPQWGQVNYARTFQG 13 RMRSQDREWDFQH crystal 2.30A 18.20% ? 23-JUL-13 20130723 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 3BNC117 IN COMPLEX WITH HIV - 1 CLADE C C1086 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 7 QANGYLN 7 DGSKLER 8 QVYEFVVP 5 DYFIH 19 WINPKTGQPNNPRQFQGRV 12 ARQRSDYWDFDV crystal 3.00A 26.20% ? 23-JUL-13 20130723 IMMUNE SYSTEM STRUCTURE OF MURINE IGG2A A20G2 - FAB IN COMPLEX WITH VACCINIA ANTIGEN A33R AT THE RESOLUTION OF 2.9 ANGSTROMS MOLECULE: A33R; FRAGMENT: ECTODOMAIN (UNP RESIDUES 89 - 185); SYNONYM: EEV GLYCOPROTEIN, EEV MEMBRANE GLYCOPROTEIN, EEV MEMBRANE PHOSPHOGLYCOPROTEIN, VACV - DUKE - 164, VACV152; ENGINEERED: YES; MUTATION: YES; ? IGG2 MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 DYYIY 17 YISNGGYKTYYPDTVKG 4 GMDY crystal 2.90A 23.70% FAB 24-JUL-13 20130724 IMMUNOGLOBULIN LEN K30T MUTANT: A DOMAIN FLIP AS A RESULT OF A SINGLE AMINO ACID SUBSTITUTION MOLECULE: LEN; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: KAPPA - IV LIGHT CHAIN DIMER KAPPA ? HOMO SAPIENS 17 KSSQSVLYSSNSTNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 2.30A 19.00% LC-dimer 12-MAY-98 19980512 IMMUNE SYSTEM INSIGHT INTO HIGHLY CONSERVED H1 SUBTYPE - SPECIFIC EPITOPES IN INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 18 - 520; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVSNYGINFIN 7 TASNKGT 9 QQTKEVPYT 5 DYDMS 17 GILGGSERSYYRDSVKG 13 HGSPGYTLYAWDY crystal 2.80A 23.40% FAB 26-JUL-13 20130726 HYDROLASE / INHIBITOR / IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFSUB1 - PRODOMAIN - NIMP.M7 FAB COMPLEX MOLECULE: SUBTILISIN - LIKE SERINE PROTEASE; FRAGMENT: RPFSUB1 PRODP9 (UNP RESIDUES 127 - 219); EC: 3.4.21.61; ENGINEERED: YES ? ? MUS MUSCULUS 12 SASSSVSTSYFH 7 STSNLAS 9 HQFHRSPLT 6 SGYSWH 16 YIHYSGSTDYNDSLKA 11 YRYDGQWVFDD crystal 2.25A 19.80% FAB 26-JUL-13 20130726 HYDROLASE / INHIBITOR / IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFSUB1 - PRODOMAIN - NIMP.M7 FAB COMPLEX WITH ADDED CACL2 MOLECULE: SUBTILISIN - LIKE SERINE PROTEASE; FRAGMENT: RPFSUB1 PRODP9 (UNP RESIDUES 127 - 219); EC: 3.4.21.61; ENGINEERED: YES ? ? MUS MUSCULUS 12 SASSSVSTSYFH 7 STSNLAS 9 HQFHRSPLT 6 SGYSWH 16 YIHYSGSTDYNDSLKA 11 YRYDGQWVFDD crystal 2.26A 19.40% FAB 26-JUL-13 20130726 HYDROLASE CRYSTAL STRUCTURE ANALYSIS OF FAB - BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH AMYLOID - BETA (1 - 40) MOLECULE: INSULIN - DEGRADING ENZYME; SYNONYM: ABETA - DEGRADING PROTEASE, INSULIN PROTEASE, INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 8 RASSSAVA 7 STSSLYS 10 QQSSPSFLIT 5 SYSIH 17 SISSYYGSTSYADSVKG 20 DRVMYYWSFSKYGYPYGMDY crystal 3.50A 23.00% FAB 02-AUG-13 20130802 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 FAB 447 - 52D IN COMPLEX WITH V3 CYCLIC PEPTIDE MN MOLECULE: CYCLIC V3 ARCH PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSSSNIGNNYVL 7 GNNKRPS 12 ATWDSGLSADWV 5 DVWLN 19 RIKSRTDGGTTDYAASVKG 20 DGFIMIRGVSEDYYYYYMDV crystal 1.80A 18.80% FAB 02-AUG-13 20130802 IMMUNE SYSTEM STRUCTURE OF MURINE IGG2A A27D7 - FAB IN COMPLEX WITH VACCINIA ANTIGEN A33R AT THE RESOLUTION OF 1.6 ANGSTROMS MOLECULE: A33R; FRAGMENT: ECTODOMAIN (UNP RESIDUES 89 - 185); SYNONYM: EEV GLYCOPROTEIN, EEV MEMBRANE GLYCOPROTEIN, EEV MEMBRANE PHOSPHOGLYCOPROTEIN, VACV - DUKE - 164, VACV152; ENGINEERED: YES; MUTATION: YES ? IGG2 MUS MUSCULUS 12 SASSSISSNYLH 7 RTSNLAS 9 QQGSSIPFT 5 DYGVS 16 VTWGGGTTYYNSALKS 10 HKASYNGLDY crystal 1.60A 20.30% FAB 02-AUG-13 20130802 IMMUNE SYSTEM STRUCTURE OF A SINGLE - DOMAIN CAMELID ANTIBODY FRAGMENT CAB - H7S SPECIFIC OF THE BLAP BETA - LACTAMASE FROM BACILLUS LICHENIFORMIS ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 ITTMG 16 LINSVGDTTYAGSVKG 12 FMSTNSGRTGSF crystal 1.95A 20.80% HC-dimer 06-AUG-13 20130806 HYDROLASE / IMMUNE SYSTEM STRUCTURE OF A SINGLE DOMAIN CAMELID ANTIBODY FRAGMENT CAB - H7S IN COMPLEX WITH THE BLAP BETA - LACTAMASE FROM BACILLUS LICHENIFORMIS ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BACILLUS LICHENIFORMIS; ORGANISM_TAXID: 1402; GENE: PENP, BLAP; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PNY; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PMES4 0 0 0 0 0 0 crystal 1.48A 16.30% VHH 06-AUG-13 20130806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - RABIES GLYCOPROTEIN FAB 523 - 11 ? ? ? MUS MUSCULUS 11 RASQIIGTSIH 7 YASESIS 9 QQSNSWPVT 5 DYNMD 17 DISPYYGSTGYSQKFKG 10 RNYDGSWFAY crystal 1.85A 19.60% FAB 06-AUG-13 20130806 TRANSPORT PROTEIN X - RAY STRUCTURE OF DOPAMINE TRANSPORTER ELUCIDATES ANTIDEPRESSANT MECHANISM MOLECULE: TRANSPORTER; FRAGMENT: SEE REMARK 999; SYNONYM: DOPAMINE TRANSPORTER, GFP; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 2.96A 22.30% FAB 06-AUG-13 20130806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING FAB 5J8 ? ? ? HOMO SAPIENS 11 GGNNIGTKVLH 7 DDSDRPS 11 QVWDISTDQAV 6 SNYYWG 16 SIYHSGSTYYKPSLES 15 HVRSGYPDTAYYFDK crystal 1.55A 17.30% FAB 08-AUG-13 20130808 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY 5J8 BOUND TO 2009 PANDEMIC INFLUENZA HEMAGGLUTININ, HA1 SUBUNIT MOLECULE: HEMAGGLUTININ HA1 CHAIN; FRAGMENT: UNP RESIDUES 63 - 285; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNNIGTKVLH 7 DDSDRPS 11 QVWDISTDQAV 6 SNYYWG 16 SIYHSGSTYYKPSLES 15 HVRSGYPDTAYYFDK crystal 2.25A 19.30% FAB 08-AUG-13 20130808 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNLIGANDED ANTI - DNA FAB A52 ? ? ? MUS MUSCULUS 17 KSSQSVLYSSNQKNYLA 7 WASTRES 8 HQHLSSWT 5 GYNMN 17 KINPYYGSTSYNQKFKG 11 GRLRRGGYFDY crystal 1.62A 19.60% FAB 08-AUG-13 20130808 IMMUNE SYSTEM ONTOGENY OF RECOGNITION SPECIFICITY AND FUNCTIONALITY FOR THE ANTI - HIV NEUTRALIZING ANTIBODY 4E10 MOLECULE: T117; ENGINEERED: YES KAPPA ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPST 5 SYAIS 17 GIIPIFGTANYAQKFQG 18 EGTTGSGWLGKPIGAFAY crystal 1.80A 19.10% FV 08-AUG-13 20130808 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 23 ANTIBODY CNTO1959 AT PH 9.5 MOLECULE: CNTO1959 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGSGYDVH 7 GNSKRPS 11 ASWTDGLSLVV 5 NYWIG 17 IIDPSNSYTRYSPSFQG 8 WYYKPFDV crystal 2.00A 18.50% ? 09-AUG-13 20130809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - IL - 23 ANTIBODY CNTO1959 AT PH 6.5 MOLECULE: CNTO1959 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGSGYDVH 7 GNSKRPS 11 ASWTDGLSLVV 5 NYWIG 17 IIDPSNSYTRYSPSFQG 8 WYYKPFDV crystal 2.00A 18.20% ? 09-AUG-13 20130809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - NGF ANTIBODY CNTO7309 MOLECULE: CNTO7309 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISSALA 7 DASSLES 9 QQFNSYPLT 5 SYSMN 17 YISRSSHTIFYADSVKG 14 VYSSGWHVSDYFDY crystal 2.80A 18.90% ? 09-AUG-13 20130809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF S25 - 26 IN COMPLEX WITH KDO (2.8) KDO (2.4) KDO TRISACCHARIDE WITH KDO (2.8) KDO (2.4) KDO TRISACCHARIDE ? ? MUS MUSCULUS 16 RSSQYIVHRNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 TYGVH 16 VIWSGGSTDYNAAFIS 10 MRITTDWFAY crystal 1.95A 21.30% FAB 12-AUG-13 20130812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - TISSUE FACTOR ANTIBODY 10H10 MOLECULE: 10H10 LIGHT CHAIN; FRAGMENT: SEE REMARK 999; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSLLSSGNQKNYLT 7 WASTRES 9 QNDYTYPLT 5 TYWIE 17 DILPGSGSTNYNENFKG 11 SGYYGNSGFAY crystal 1.90A 20.60% ? 12-AUG-13 20130812 BLOOD CLOTTING / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN TISSUE FACTOR EXTRACELLULAR DOMAIN AND ANTIBODY 10H10 FAB FRAGMENT MOLECULE: TISSUE FACTOR; FRAGMENT: EXTRACELLULAR DOMAIN (UNP RESIDUES 37 - 245); SYNONYM: TF, COAGULATION FACTOR III, THROMBOPLASTIN; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSLLSSGNQKNYLT 7 WASTRES 9 QNDYTYPLT 5 TYWIE 17 DILPGSGSTNYNENFKG 11 SGYYGNSGFAY crystal 3.40A 24.50% FAB 12-AUG-13 20130812 IMMUNE SYSTEM UNLIGANDED 1 CRYSTAL STRUCTURE OF S25 - 26 FAB ? ? ? MUS MUSCULUS 16 RSSQYIVHRNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 TYGVH 16 VIWSGGSTDYNAAFIS 10 MRITTDWFAY crystal 2.75A 21.70% FAB 12-AUG-13 20130812 IMMUNE SYSTEM ONTOGENY OF RECOGNITION SPECIFICITY AND FUNCTIONALITY FOR THE ANTI - HIV NEUTRALIZING ANTIBODY 4E10 MOLECULE: 4E10 EPITOPE SCAFFOLD T117; ENGINEERED: YES KAPPA ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPST 5 SYAIS 17 GIIPIFGTANYAQKFQG 5 EGTTG crystal 2.89A 26.30% FV 13-AUG-13 20130813 IMMUNE SYSTEM UNLIGANDED 2 CRYSTAL STRUCTURE OF S25 - 26 FAB ? ? ? MUS MUSCULUS 16 RSSQYIVHRNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 TYGVH 16 VIWSGGSTDYNAAFIS 10 MRITTDWFAY crystal 2.09A 21.90% FAB 14-AUG-13 20130814 IMMUNE SYSTEM UNLIGANDED 3 CRYSTAL STRUCTURE OF S25 - 26 FAB ? ? ? MUS MUSCULUS 16 RSSQYIVHRNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 TYGVH 16 VIWSGGSTDYNAAFIS 10 MRITTDWFAY crystal 2.32A 23.10% FAB 15-AUG-13 20130815 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HINGE RABBIT ANTIBODY C2095 MOLECULE: C2095 LIGHT CHAIN; FRAGMENT: SEE REMARK 999; ENGINEERED: YES; ? ? ORYCTOLAGUS CUNICULUS, HOMO SAPIENS 13 QASQSVYNKNYLA 7 SASTLAS 13 LGSYDCNRAECHA 5 SYPMN 16 GIGTSGNIWYASWAKG 8 GLYNDYTV crystal 2.00A 18.10% ? 15-AUG-13 20130815 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOUSE PRION PROTEIN COMPLEXED WITH PROMAZINE MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: UNP RESIDUES 116 - 229; SYNONYM: PRP, PRP27 - 30, PRP33 - 35C; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 1.97A 21.70% FAB 15-AUG-13 20130815 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOUSE PRION PROTEIN COMPLEXED WITH CHLORPROMAZINE MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: UNP RESIDUES 116 - 229; SYNONYM: PRP, PRP27 - 30, PRP33 - 35C; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 2.20A 19.70% FAB 15-AUG-13 20130815 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - ST2L ANTIBODY C2244 MOLECULE: C2244 LIGHT CHAIN; FRAGMENT: SEE REMARK 999; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 15 RASKSVSTSGSSYMF 7 LASNLES 9 QHSREIPYT 6 SDYAWN 16 FISYSGDTSFNPSLKS 8 YDGYSFDY crystal 1.90A 18.50% ? 16-AUG-13 20130816 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB H5M9 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A / VIET NAM / 1203 / 2004 (H5N1) MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: MEMBRANE FUSION DOMAIN (UNP RESIDUES 347 - 520); ENGINEERED: YES; KAPPA ? MUS MUSCULUS 15 RASESVDNFGKSFMH 7 RASNREF 9 QQSNEDPRT 5 EYTIH 17 GIFPNNGDTTYNQKFKV 11 NYGSSYGYFDV crystal 3.56A 20.30% FAB 29-AUG-13 20130829 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB H5M9 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A / GOOSE / GUANGDONG / 1 / 96 (H5N1) MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: MEMBRANE FUSION DOMAIN (UNP RESIDUES 347 - 521); ENGINEERED: YES; KAPPA ? MUS MUSCULUS 15 RASESVDNFGKSFMH 6 RASNRE 9 QQSNEDPRT 5 EYTIH 17 GIFPNNGDTTYNQKFKV 11 NYGSSYGYFDV crystal 6.98A 38.00% FAB 29-AUG-13 20130829 IMMUNE SYSTEM T CELL RESPONSE TO A HIV REVERSE TRANSCRIPTASE EPITOPE PRESENTED BY THE PROTECTIVE ALLELE HLA - B *51:01 MOLECULE: BETA - 2 - MICROGLOBULIN; SYNONYM: BETA - 2 - MICROGLOBULIN FORM PI 5.3; ENGINEERED: YES; ? ? HOMO SAPIENS 10 DPISGHTALY 7 FQGTGAA 15 AVYLCASSLTGGGEL 0 N/A 0 N/A 0 N/A crystal 2.99A 24.50% LC-dimer 03-SEP-13 20130903 SIGNALING PROTEIN STRUCTURE OF ACTIVE HUMAN M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND TO THE AGONIST IPEROXO MOLECULE: MUSCARINIC ACETYLCHOLINE RECEPTOR M2; FRAGMENT: UNP RESIDUES 1 - 232, 373 - 466; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 NFDDYAI 17 SCIDPSDGSTIYADSAK 10 AWTLFHSDEY crystal 3.50A 25.40% HC-dimer 16-SEP-13 20130916 SIGNALING PROTEIN STRUCTURE OF ACTIVE HUMAN M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND TO THE AGONIST IPEROXO AND ALLOSTERIC MODULATOR LY2119620 MOLECULE: MUSCARINIC ACETYLCHOLINE RECEPTOR M2; FRAGMENT: UNP RESIDUES 1 - 232,373 - 466; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 NFDDYAI 17 SCIDPSDGSTIYADSAK 10 AWTLFHSDEY crystal 3.70A 25.50% HC-dimer 16-SEP-13 20130916 METAL TRANSPORT, MEMBRANE PROTEIN CLC - EC1 FAB COMPLEX CYSLESS A399C - A432C MUTANT MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.52A 22.50% FAB 16-SEP-13 20130916 TRANSPORT PROTEIN Y78 ESTER MUTANT OF KCSA IN HIGH K+ MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 22 - 124; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL, SKC1; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.06A 19.90% FAB 18-SEP-13 20130918 IMMUNE SYSTEM STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3C MOLECULE: ENVELOPE GLYCOPROTEIN E2; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSVSSNLA 7 GASTRAT 9 QQYYRSPLT 5 NYALN 17 GVVPLFGTTRNAQKFQG 18 SVTPRYCGGGFCYGEFDY crystal 2.65A 23.30% FAB 24-SEP-13 20130924 CYTOKINE / IMMUNE SYSTEM STRUCTURE OF LYMPHOTOXIN ALPHA BOUND TO ANTI - LTA FAB MOLECULE: LYMPHOTOXIN - ALPHA; SYNONYM: LT - ALPHA, TNF - BETA, TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQAVSSAVA 7 SASHRYT 9 QESYSTPWT 5 SYVIH 17 YNNPYNAGTNYNEKFKG 9 PTMLPWFAY crystal 3.20A 18.10% FAB 26-SEP-13 20130926 CYTOKINE / IMMUNE SYSTEM STRUCTURE OF HETEROTRIMERIC LYMPHOTOXIN LTA1B2 BOUND TO LYMPHOTOXIN BETA RECEPTOR LTBR AND ANTI - LTA FAB MOLECULE: LYMPHOTOXIN - ALPHA; SYNONYM: LT - ALPHA, TNF - BETA, TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQAVSSAVA 7 SASHRYT 9 QESYSTPWT 5 SYVIH 17 YNNPYNAGTNYNEKFKG 9 PTMLPWFAY crystal 3.60A 23.40% FAB 26-SEP-13 20130926 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C ENVELOPE GLYCOPROTEIN E1 ANTIGENIC REGION 314 - 324 BOUND TO THE CROSS - NEUTRALIZING ANTIBODY IGH526 MOLECULE: HCV E1 PEPTIDE; FRAGMENT: ANTIGENIC SITE (UNP RESIDUES 314 - 324); ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSSSNIGGNTVN 7 NNDLRPS 11 AAWDDGLNGWV 5 SYAIH 17 WINPGNGNAKYSQRFQG 16 DRGFDLLTGHYLGLDP crystal 1.75A 18.00% ? 02-OCT-13 20131002 IMMUNE SYSTEM / HYDROLASE STRUCTURAL EVIDENCE FOR ANTIGEN RECEPTOR EVOLUTION MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? HOMO SAPIENS 11 RASQDIASDLN 7 SDSYLQS 9 QQYYMIPST 0 N/A 0 N/A 0 N/A crystal 1.70A 19.90% LC-dimer 03-OCT-13 20131003 IMMUNE SYSTEM / HYDROLASE STRUCTURAL EVIDENCE FOR ANTIGEN RECEPTOR EVOLUTION MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C, ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? HOMO SAPIENS 11 RASQDIAAALN 7 ASSYLQS 9 QQDGYYPAT 0 N/A 0 N/A 0 N/A crystal 2.23A 22.50% LC-dimer 04-OCT-13 20131004 HYDROLASE / IMMUNE SYSTEM STRUCTURE OF A SINGLE - DOMAIN CAMELID ANTIBODY FRAGMENT CAB - F11N IN COMPLEX WITH THE BLAP BETA - LACTAMASE FROM BACILLUS LICHENIFORMIS MOLECULE: BETA - LACTAMASE; FRAGMENT: UNP RESIDUES 44 - 307; SYNONYM: PENICILLINASE, LARGE EXOPENICILLINASE, SMALL EXOPENICILLINASE; EC: 3.5.2.6; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 17 AISRSGGDTKYADSVKG 18 TTYASLSDTYIGEHIYDD crystal 3.00A 21.20% HC-dimer 04-OCT-13 20131004 IMMUNE SYSTEM THREE - DIMENSIONAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MATRIX PROTEIN 2 OF INFLUENZA A VIRUS MOLECULE: EXTRACELLULAR DOMAIN OF INFLUENZA MATRIX PROTEIN 2; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLFYSSYQKDLLA 7 WASTRES 9 QQYYTYPLT 5 DYAMH 17 VIGTDNGNTNYNQKFKG 10 RDRDDVWFAY crystal 1.60A 19.60% ? 17-OCT-13 20131017 APOPTOSIS / IMMUNE SYSTEM CRYSTAL STRUCTURE OF TERNARY COMPLEX OF TRAIL, DR5, AND FAB FRAGMENT FROM A DR5 AGONIST ANTIBODY MOLECULE: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10; FRAGMENT: UNP RESIDUES 114 - 281; SYNONYM: APO - 2 LIGAND, APO - 2L, TNF - RELATED APOPTOSIS - INDUCING LIGAND, PROTEIN TRAIL; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQGISRSYLA 7 GASSRAT 9 QQFGSSPWT 7 SGDYFWS 16 HIHNSGTTYYNPSLKS 12 DRGGDYYYGMDV crystal 3.30A 22.90% FAB 18-OCT-13 20131018 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A COMPUTATIONALLY DESIGNED RSV - PRESENTING EPITOPE SCAFFOLD AND ITS ELICITED ANTIBODY 17HD9 MOLECULE: EPITOPE SCAFFOLD RSV_1ISEA_FFL_001_C; ENGINEERED: YES ? ? MACACA MULATTA 11 RASQGISNYLA 7 YTSHLES 9 QQHNSYPRT 5 SYYWT 17 EMNGNSGYTNYNPSLQS 16 DAIVMVFTDMRGRVDV crystal 2.50A 26.50% ? 21-OCT-13 20131021 MEMBRANE PROTEIN / PROTEIN BINDING PROBING THE N - TERMINAL BETA - SHEET CONVERSION IN THE CRYSTAL STRUCTURE OF THE HUMAN PRION PROTEIN BOUND TO A NANOBODY MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: C - TERMINAL RESIDUES 90 - 231; SYNONYM: PRP, ASCR, PRP27 - 30, PRP33 - 35C; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYNMG 17 SITSSGDKSDYTDSVKG 15 GLGIYIIRARGGYDH crystal 1.50A 15.10% HC-dimer 21-OCT-13 20131021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CLOSTRIDIUM DIFFICILE TOXIN A FRAGMENT TCDA - A1 BOUND TO A20.1 VHH MOLECULE: TCDA; FRAGMENT: UNP RESIDUES 2573 - 2709; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 MDPMA 19 VAAGSSTGRTTYYADSVKG 14 APYGANWYRDEYAY crystal 1.75A 19.70% HC-dimer 23-OCT-13 20131023 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TCDA - A2 BOUND TO TWO MOLECULES OF A20.1 VHH MOLECULE: CELL WALL - BINDING REPEAT PROTEIN; FRAGMENT: UNP RESIDUES 1 - 248; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 MDPMA 19 VAAGSSTGRTTYYADSVKG 14 APYGANWYRDEYAY crystal 2.08A 21.20% HC-dimer 23-OCT-13 20131023 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TCDA - A1 BOUND TO A26.8 VHH MOLECULE: TCDA; FRAGMENT: UNP RESIDUES 2573 - 2709; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RYPVA 17 VISSTGTSTYYADSVKG 15 NSQRTRLQDPNEYDY crystal 1.75A 20.80% HC-dimer 23-OCT-13 20131023 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TCDA - A2 BOUND TO A26.8 VHH MOLECULE: CELL WALL - BINDING REPEAT PROTEIN; FRAGMENT: UNP RESIDUES 1 - 248; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RYPVA 17 VISSTGTSTYYADSVKG 15 NSQRTRLQDPNEYDY crystal 2.30A 20.10% HC-dimer 23-OCT-13 20131023 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TCDA - A2 BOUND TO A20.1 VHH AND A26.8 VHH MOLECULE: CELL WALL - BINDING REPEAT PROTEIN; FRAGMENT: UNP RESIDUES 1 - 248; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 MDPMA 19 VAAGSSTGRTTYYADSVKG 14 APYGANWYRDEYAY crystal 2.61A 20.50% HC-dimer 23-OCT-13 20131023 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TCDB - B1 BOUND TO B39 VHH MOLECULE: TOXIN B; FRAGMENT: UNP RESIDUES 2248 - 2366; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RYVMG 16 AITWGGTPNYADSVKG 14 GLGWDSRYSQSYNY crystal 2.50A 19.40% HC-dimer 23-OCT-13 20131023 IMMUNE SYSTEM NEUTRALIZING ANTIBODY TO MURINE NOROVIRUS ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 STSNLAS 9 QQRSSYPFT 5 RYWMS 17 QINPHSSTINYTPSLRD 10 LLRYFYALDY crystal 2.49A 20.70% FAB 24-OCT-13 20131024 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV - 1 ENV TRIMER IN COMPLEX WITH THE BROADLY NEUTRALIZING FAB PGT122 MOLECULE: BG505 SOSIP GP41; FRAGMENT: SEE REMARK 999; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GEESLGSRSVI 7 NNNDRPS 15 YYCHIWDSRRPTNWV 5 DNYWS 16 YVHDSGDTNYNPSLKS 24 TKHGRRIYGVVAFKEWFTYFYMDV crystal 4.70A 37.60% FAB 24-OCT-13 20131024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 NEUTRALIZING ANTIBODY 4E10 FAB FRAGMENT IN COMPLEX WITH A HYDROCARBON - STAPLED PEPTIDE CONTAINING THE 4E10 EPITOPE ON GP41 AND A TETHERED PHOSPHATE MOIETY. MOLECULE: MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41); ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.68A 17.20% FAB 01-NOV-13 20131101 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HIV - 1 NEUTRALIZING ANTIBODY 4E10 FAB FRAGMENT IN COMPLEX WITH A HYDROCARBON - STAPLED PEPTIDE CONTAINING THE 4E10 EPITOPE ON GP41. MOLECULE: MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41); ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.91A 21.30% FAB 04-NOV-13 20131104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 2G12 IGG DIMER MOLECULE: HEPATITIS B VIRUS RECEPTOR BINDING PROTEIN; FRAGMENT: UNP RESIDUES 139 - 348; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 8 KGSDRLDA crystal 8.00A 36.00% ? 05-NOV-13 20131105 IMMUNE SYSTEM STRUCTURE OF 2G12 IGG DIMER MOLECULE: 2G12 IGG DIMER HEAVY CHAIN; FRAGMENT: UNP RESIDUES 139 - 348; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 16 SISSSTYRDYADAVKG 8 KGSDRLDA crystal 6.50A 38.10% ? 05-NOV-13 20131105 ONCOPROTEIN / IMMUNE SYSTEM STRUCTURE OF HUMAN GANKYRIN IN COMPLEX TO THE SINGLE CHAIN ANTIBODY F5 MOLECULE: 26S PROTEASOME NON - ATPASE REGULATORY SUBUNIT 10; SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT P28, GANKYRIN, P28 (GANK); ENGINEERED: YES; ? ? HOMO SAPIENS 17 AASGFTFSNYSMNWVRQ 7 SRYIYYA 15 YYCVRGVIDKFDYWG 5 NYSMN 17 SISGSSRYIYYADFVKG 26 GVIDKFDYWGRGTLVTVSASQSVLTQ crystal 2.50A 16.60% scFv 06-NOV-13 20131106 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 8B10 IN COMPLEX WITH MPTS MOLECULE: 8B10 LIGHT CHAIN; ? ? MUS MUSCULUS 15 RASESVDSYGISFMH 7 RASNLES 9 QQSNEDPRT 5 DYYMH 17 YIYPNNGGNGYNQKFKG 12 RGGYGSRGYFDV crystal 1.95A 21.70% FAB 08-NOV-13 20131108 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 6C8 IN COMPLEX WITH MPTS MOLECULE: 6C8 LIGHT CHAIN; ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQSNEDPRT 5 DYYMH 17 YIYPNNGGNGYNQKFKG 12 RGGYGIRGYFDV crystal 2.20A 21.90% FAB 08-NOV-13 20131108 IMMUNE SYSTEM / CHAPERONE CRYSTAL STRUCTURE OF ENGINEERED ANTI - EE SCFV ANTIBODY FRAGMENT ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSLVPPT 7 TAGMGVN 16 HIYWDDDKRYNPSLKS 12 RGGSSHYYAMDY crystal 3.30A 19.70% FV 12-NOV-13 20131112 CYTOKINE CRYSTAL STRUCTURE OF A FAB ? ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 DVSNRPS 10 SSYTSSSTRV 5 SYIMM 17 SIYPSGGITFYADTVKG 11 IKLGTVTTVDY crystal 2.41A 20.00% FAB 12-NOV-13 20131112 IMMUNE SYSTEM / CHAPERONE CRYSTAL STRUCTURE OF ENGINEERED ANTI - EE SCFV ANTIBODY FRAGMENT ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSLVPPT 7 TKGMGVN 16 HIYWDDDKRYNPSLKS 12 RGGSSHYYAMDY crystal 3.71A 26.50% FV 12-NOV-13 20131112 IMMUNE SYSTEM / CHAPERONE CRYSTAL STRUCTURE OF ENGINEERED ANTI - EE SCFV ANTIBODY FRAGMENT ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSLVPPT 5 DYYMN 17 DINPNNGGTSYNQKFKG 12 SSPYSMRAAMDY crystal 3.50A 31.00% FV 12-NOV-13 20131112 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR8043 ? ? ? HOMO SAPIENS 17 KSSQSVFSSSTNKNYLA 7 WSSTRES 9 HQYYTAPWT 5 AYSMH 17 WINTAIGNTQYSQKFQD 12 GASWDARGWSGY crystal 2.65A 17.80% FAB 14-NOV-13 20131114 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR8043 BOUND TO H3 INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 17 KSSQSVFSSSTNKNYLA 7 WSSTRES 9 HQYYTAPWT 5 AYSMH 17 WINTAIGNTQYSQKFQD 12 GASWDARGWSGY crystal 4.00A 24.20% ? 14-NOV-13 20131114 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF APO MANGANESE ABC TRANSPORTER MNTC FROM STAPHYLOCOCCUS AUREUS BOUND TO AN ANTAGONISTIC FAB FRAGMENT MOLECULE: LIPOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 10 QQSYYSSPFT 5 SSSIH 17 SIYSYSGYTYYADSVKG 19 QSSAEIESWYYYSGEAMDY crystal 2.69A 22.60% FAB 18-NOV-13 20131118 IMMUNE SYSTEM CLOSTRIDIUM DIFFICILE TOXIN B CROP DOMAIN IN COMPLEX WITH FAB DOMAINS OF NEUTRALIZING ANTIBODY BEZLOTOXUMAB MOLECULE: TOXIN B; FRAGMENT: CROP DOMAIN (UNP RESIDUES 1834 - 2099); ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSTWT 5 SYWIG 17 IFYPGDSSTRYSPSFQG 10 RRNWGNAFDI crystal 2.89A 19.90% FAB 20-NOV-13 20131120 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GERMLINE FAB PGT121, A PUTATIVE PRECURSOR OF THE BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 12 QVWDSRGPTNWV 5 SYYWS 16 YIYYSGSTNYNPSLKS 21 TLHGRRIYGIVEWFTYYYMDV crystal 1.80A 18.40% FAB 22-NOV-13 20131122 IMMUNE SYSTEM KNOB - INTO - HOLE IGG FC ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS; ORGANISM_TAXID: 1279 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.64A 23.00% FC 25-NOV-13 20131125 IMMUNE SYSTEM ANTI - PARALLEL FC - HOLE (T366S / L368A / Y407V) HOMODIMER ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.10A 19.80% FC 25-NOV-13 20131125 IMMUNE SYSTEM ANTI - PARALLEL FC - KNOB (T366W) HOMODIMER ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 22.60% FC 25-NOV-13 20131125 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING ANTIBODY M66 IN COMPLEX WITH GP41 MPER PEPTIDE MOLECULE: ENVELOPE GLYCOPROTEIN GP41; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSIGSYLN 7 AASTLQS 9 QQSYSTPFT 5 SEWIG 17 IIYPGDSDTKYSPSFQG 15 QNHYGSTAYYYAMDV crystal 2.21A 18.90% ? 27-NOV-13 20131127 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING ANTIBODY M66 MOLECULE: M66 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGSYLN 7 AASTLQS 9 QQSYSTPFT 5 SEWIG 17 IIYPGDSDTKYSPSFQG 13 QNHYGAYYYAMDV crystal 3.14A 22.90% ? 27-NOV-13 20131127 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 NEUTRALIZING ANTIBODY M66.6 ? ? ? HOMO SAPIENS 11 RASQHIKKYLN 7 GALNLQS 9 QQSYSTPFT 5 SEWIG 17 IIYPGDSDTKYSPSFQG 21 QNHYGSGSYFYRTAYYYAMDV crystal 2.42A 17.80% FAB 27-NOV-13 20131127 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BROADLY NEUTRALIZING ANTIBODY PGT151 MOLECULE: PGT151 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 16 KSSESLRQSNGKTSLY 7 EVSNRFS 9 MQSKDFPLT 5 KYPMY 17 AISGDAWHVVYSNSVQG 26 MFQESGPPRLDRWSGRNYYYYSGMDV crystal 1.86A 16.10% FAB 03-DEC-13 20131203 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BROADLY NEUTRALIZING ANTIBODY PGT152 MOLECULE: PGT152 LIGHT CHAIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 16 KSSQSLRQSNGKTSLY 7 EVSNRFS 9 MQSKDFPLT 5 KYPMY 17 AISADAWHVVYSGSVQG 18 MFQESGPPNYYYYSGMDV crystal 1.83A 17.00% FAB 03-DEC-13 20131203 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - HUMAN NGF FAB APE1531 ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLT 7 WASTRES 9 QQYDNYPIT 5 NYAIS 17 GIIPIFGTANYAQKFQG 19 GPEYYDYVWGSYRYNYFDY crystal 1.75A 15.20% FAB 06-DEC-13 20131206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF APE1551, AN ANTI - HUMAN NGF FAB WITH A NINE AMINO ACID INSERTION IN CDR H1 ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLT 7 WASTRES 9 QQYDNYPIT 6 SNYAIS 17 GIIPIFGTANYAQKFQG 19 GPEYYDYVWGSYRYNYFDY crystal 1.60A 16.80% FAB 06-DEC-13 20131206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ADALIMUMAB FAB FRAGMENT MOLECULE: ADALIMUMAB LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGIRNYLA 7 AASTLQS 9 QRYNRAPYT 5 DYAMH 17 AITWNSGHIDYADSVEG 12 VSYLSTASSLDY crystal 2.80A 27.70% FAB 10-DEC-13 20131210 IMMUNE SYSTEM / PROTEIN BINDING CRYSTAL STRUCTURE OF THE ANTIBODY - BINDING REGION OF PROTEIN M (PROTEIN M TD) IN COMPLEX WITH ANTI - HIV ANTIBODY PGT135 FAB MOLECULE: PROTEIN M TD; FRAGMENT: ANTIBODY - BINDING REGION (UNP RESIDUES 74 - 468); SYNONYM: PROTEIN MG281; ENGINEERED: YES ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.65A 15.60% FAB 12-DEC-13 20131212 PROTEIN BINDING / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTIBODY - BINDING REGION OF PROTEIN M (PROTEIN M TD) IN COMPLEX WITH ANTI - INFLEUNZA HEMAGGLUTININ ANTIBODY CR9114 FAB MOLECULE: PROTEIN M TD; FRAGMENT: ANTIBODY - BINDING REGION (UNP RESIDUES 74 - 468); SYNONYM: PROTEIN MG281; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 NYAIS 17 GISPIFGSTAYAQKFQG 12 HGNYYYYSGMDV crystal 2.50A 18.10% FAB 12-DEC-13 20131212 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE PRIMARY MONOCLONAL ANTIBODY 13PL FAB' FROM A MULTIPLE MYELOMA PATIENT ? ? ? HOMO SAPIENS 11 QASQDIAKFLD 7 DASNLAI 9 QHYDDFPIS 5 SYAFH 17 FISYNGSSKYYASFVSG 16 APDCADADCHKGAFGY crystal 1.20A 13.70% FAB 12-DEC-13 20131212 PROTEIN BINDING ALPHAVBETA3 INTEGRIN IN COMPLEX WITH MONOCLONAL ANTIBODY FAB FRAGMENT. MOLECULE: INTEGRIN BETA - 3; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDISNYLS 7 YTSKLHS 9 QQGNTFPYT 5 SFWMH 17 YINPRSGYTECNEIFRD 9 FLGRGAMDY crystal 3.60A 25.00% FAB 13-DEC-13 20131213 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - HINGE RABBIT ANTIBODY 2095 - 2 IN COMPLEX WITH IDES HINGE PEPTIDE MOLECULE: IDES HINGE PEPTIDE; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS, HOMO SAPIENS 13 QASQSVYNKNYLA 7 SASTLAS 13 LGSYDCNRAECHA 5 SYPMN 16 GIGTSGNIWYASWAKG 8 GLYNDYTV crystal 1.85A 19.40% ? 19-DEC-13 20131219 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE QAA VARIANT OF ANTI - HINGE RABBIT ANTIBODY 2095 - 2 IN COMPLEX WITH IDES HINGE PEPTIDE MOLECULE: IDES HINGE PEPTIDE; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS, HOMO SAPIENS 13 QASQSVYNKNYLA 7 SASTLAS 10 LGSYDQAAHA 5 SYPMN 16 GIGTSGNIWYASWAKG 8 GLYNDYTV crystal 2.20A 18.40% ? 19-DEC-13 20131219 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY F045 - 092 IN COMPLEX WITH A / VICTORIA / 3 / 1975 (H3N2) INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: HEMAGGLUTININ HA2 CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSRSNIGGNTVN 7 SSNQRSS 11 ASWDDSLNGVV 4 YAIN 17 GIIPFFGTTNYAQKFQG 23 PSITESHYCLDCAAKDYYYGLDV crystal 2.75A 18.00% FAB 19-DEC-13 20131219 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY F045 - 092 IN COMPLEX WITH A / VICTORIA / 361 / 2011 (H3N2) INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: HEMAGGLUTININ HA2 CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSRSNIGGNTVN 7 SSNQRSS 11 ASWDDSLNGVV 4 YAIN 17 GIIPFFGTTNYAQKFQG 23 PSITESHYCLDCAAKDYYYGLDV crystal 6.50A 20.30% FAB 19-DEC-13 20131219 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY F045 - 092 ? ? ? HOMO SAPIENS 13 SGSRSNIGGNTVN 7 SSNQRSS 11 ASWDDSLNGVV 4 YAIN 17 GIIPFFGTTNYAQKFQG 23 PSITESHYCLDCAAKDYYYGLDV crystal 1.50A 17.60% FAB 19-DEC-13 20131219 IMMUNE SYSTEM STRUCTURE OF INTERLEUKIN - 6 IN COMPLEX WITH A CAMELID FAB FRAGMENT MOLECULE: INTERLEUKIN - 6; FRAGMENT: UNP RESIDUES 28 - 212; SYNONYM: IL - 6, B - CELL STIMULATORY FACTOR 2, BSF - 2, CTL DIFFERENTIATION FACTOR, CDF, HYBRIDOMA GROWTH FACTOR, INTERFERON BETA - 2, IFN - BETA - 2; ENGINEERED: YES; ? ? LLAMA GLAMA 14 GLSSGSVTASNYPG 7 STNDRHS 9 ALDIGDITE 5 SYRMY 17 AISAGGGSTYYGDSVKG 9 RAGWGMGDY crystal 2.42A 21.70% FAB 02-JAN-14 20140102 IMMUNE SYSTEM FAB STRUCTURE OF ANTI - HIV GP120 V2 MAB 2158 ? ? ? HOMO SAPIENS 11 RASQTISSWLA 7 KASSIVS 9 QQYNSSPET 5 SYTIS 17 RITPIFDITNYAQKFQG 21 DKSDVVVVTSIRPAYYYGMDV crystal 2.80A 18.60% FAB 06-JAN-14 20140106 IMMUNE SYSTEM ONTOGENY OF RECOGNITION SPECIFICITY AND FUNCTIONALITY FOR THE BROADLY NEUTRALIZING ANTI - HIV ANTIBODY 4E10 ? ? ? HOMO SAPIENS 12 CRASQSVSSSYL 7 YGASSRA 10 CQQYGSSPST 3 AIS 17 GIIPIFGTANYAQKFQG 17 EGTTGGWLGKPIGAFQH crystal 1.70A 18.00% FV 06-JAN-14 20140106 HYDROLASE, PROTEIN BINDING CRYSTAL STRUCTURE OF THE RPN8 - RPN11 MPN DOMAIN HETERODIMER, CRYSTAL FORM IA MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN11; FRAGMENT: UNP RESIDUES 1 - 220; SYNONYM: PROTEIN MPR1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 STVMA 17 TIRWSGGNTYYADSVKG 13 GTYYGTLSYKYDF crystal 2.40A 19.80% HC-dimer 09-JAN-14 20140109 HYDROLASE, PROTEIN BINDING CRYSTAL STRUCTURE OF THE RPN8 - RPN11 MPN DOMAIN HETERODIMER, CRYSTAL FORM IB MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN11; FRAGMENT: UNP RESIDUES 1 - 220; SYNONYM: PROTEIN MPR1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 STVMA 17 TIRWSGGNTYYADSVKG 13 GTYYGTLSYKYDF crystal 1.99A 21.80% HC-dimer 09-JAN-14 20140109 HYDROLASE, PROTEIN BINDING CRYSTAL STRUCTURE OF THE RPN8 - RPN11 MPN DOMAIN HETERODIMER, CRYSTAL FORM II MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN11; FRAGMENT: UNP RESIDUES 1 - 220; SYNONYM: PROTEIN MPR1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 2 MA 17 TIRWSGGNTYYADSVKG 13 GTYYGTLSYKYDF crystal 2.25A 23.50% HC-dimer 09-JAN-14 20140109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.01, A POTENT V1V2 - DIRECTED HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGSSSTIGNNYVS 7 KNDNRPS 12 GTWDTSLSGGGV 5 NFAMG 17 FISSDGSNKNYGDSVKG 21 DVGDYKSPIQDPRAMVGAFDL crystal 1.90A 18.10% FAB 09-JAN-14 20140109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.10, A POTENT V1V2 - DIRECTED HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGSSSNIGDNYVS 7 ENTRRPS 12 GTWDVRPNRGAV 5 GHGLH 17 SISFAGTKMDYADSVKG 25 DMREYECEYWTPCIDRRGVVGIFDM crystal 1.90A 21.20% FAB 09-JAN-14 20140109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.06, A POTENT V1V2 - DIRECTED HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGSTSKIGQNSVS 7 ENDRRPS 9 ETWDGSGGV 5 NYGMH 17 GISFAGIKKYYGTSVKG 26 DLRELECEEWTLNYDRGPCVDPRGVA crystal 3.00A 19.50% FAB 09-JAN-14 20140109 IMMUNE SYSTEM FAB COMPLEX WITH METHOTREXATE WITH METHOTREXATE ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSTRFS 9 FQGSHVPLT 6 SPYAWN 16 YISYRGSTTYHPSLKS 8 YGNYGAYS crystal 2.39A 18.80% FAB 09-JAN-14 20140109 IMMUNE SYSTEM FAB FOR METHOTREXATE (UNBOUND APO) ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSTRFS 9 FQGSHVPLT 6 SPYAWN 16 YISYRGSTTYHPSLKS 8 YGNYGAYS crystal 2.79A 18.30% FAB 09-JAN-14 20140109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.03, A POTENT V1V2 - DIRECTED HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGSSSNIGNNFVS 7 ENNKRPS 12 ATWSASLSSARV 5 RYGMH 19 AISYDGTDKYHADKVWGRF 26 DLREDECEEWWSDDFGKQLPCRKSRG crystal 2.69A 20.50% FAB 09-JAN-14 20140109 APOPTOSIS / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF AN ANTI - DR5 ANTIBODY BOUND TO DR5 MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; FRAGMENT: UNP RESIDUES 73 - 183; SYNONYM: DEATH RECEPTOR 5, TNF - RELATED APOPTOSIS - INDUCING LIGAND RECEPTOR 2, TRAIL RECEPTOR 2, TRAIL - R2; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDSLRSYYAS 7 GANNRPS 11 NSADSSGNHVV 5 DYAMS 17 GINWQGGSTGYADSVKG 12 ILGAGRGWYFDY crystal 3.20A 24.80% FAB 09-JAN-14 20140109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.07, A POTENT V1V2 - DIRECTED HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGSGSNIGNNFVS 7 ESNKRPS 12 ATWAARLNSARV 5 RYGMH 19 GISFDGTDRYHADNVWGRF 24 DLREDECEEWPCRKSRGVAGVFDK crystal 2.62A 22.20% FAB 09-JAN-14 20140109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.UCA, A POTENT V1V2 - DIRECTED HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 ENNKRPS 8 GTWDSGGV 5 SYGMH 17 VISYDGSNKYYADSVKG 15 DLGESENGVVGAFDI crystal 2.89A 22.50% FAB 10-JAN-14 20140110 IMMUNE SYSTEM UNLIGANDED FAB STRUCTURE OF LIPID A - SPECIFIC ANTIBODY S55 - 3 ? ? ? MUS MUSCULUS 15 RASETVDSYGNSFMH 7 RASNLES 9 QQSNEDPRT 5 GYGMS 17 LISNGGSYAYYSDSVKG 13 HKGLRGGTNAMDY crystal 1.94A 21.20% FAB 10-JAN-14 20140110 IMMUNE SYSTEM FAB STRUCTURE OF LIPID A - SPECIFIC ANTIBODY S1 - 15 IN COMPLEX WITH LIPID A CARBOHYDRATE BACKBONE WITH LIPID A CARBOHYDRATE BACKBONE KAPPA ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLRS 9 QQGNTLPWT 5 TYAMN 19 RIRSKSNNYATYYADSVKD 16 HRGAPLYYGNGAWFAY crystal 1.95A 19.90% FAB 10-JAN-14 20140110 IMMUNE SYSTEM UNLIGANDED FAB STRUCTURE OF LIPID A - SPECIFIC ANTIBODY S1 - 15 ? KAPPA ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLRS 9 QQGNTLPWT 5 TYAMN 19 RIRSKSNNYATYYADSVKD 16 HRGAPLYYGNGAWFAY crystal 2.29A 19.00% FAB 10-JAN-14 20140110 IMMUNE SYSTEM FAB STRUCTURE OF LIPID A - SPECIFIC ANTIBODY A6 IN COMPLEX WITH LIPID A CARBOHYDRATE BACKBONE WITH LIPID A CARBOHYDRATE BACKBONE KAPPA ? MUS MUSCULUS 11 RASQDIRNYLS 7 YTSKLHS 10 QQGKTLPLYT 5 SYYMS 17 AINSNGGNTYYPDTVKG 13 LYGNYVRIHTMDY crystal 2.15A 20.70% FAB 10-JAN-14 20140110 IMMUNE SYSTEM UNLIGANDED FAB STRUCTURE OF LIPID A - SPECIFIC ANTIBODY A6 ? KAPPA ? MUS MUSCULUS 11 RASQDIRNYLS 7 YTSKLHS 10 QQGKTLPLYT 5 SYYMS 17 AINSNGGNTYYPDTVKG 13 LYGNYVRIHTMDY crystal 2.72A 23.30% FAB 10-JAN-14 20140110 IMMUNE SYSTEM 4E10 GERMLINE ENCODED PRECURSOR NO.7 IN COMPLEX WITH EPITOPE SCAFFOLD T117 MOLECULE: 4E10 EPITOPE SCAFFOLD T117; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPST 5 SYAIS 17 GIIPIFGTANYAQKFQG 18 EGTTGWGWLGKPIGAFQH crystal 3.10A 28.10% FV 10-JAN-14 20140110 HORMONE RECEPTOR / HORMONE / IMMUNE SYSTEM INSULIN IN COMPLEX WITH SITE 1 OF THE HUMAN INSULIN RECEPTOR MOLECULE: INSULIN B CHAIN; FRAGMENT: UNP RESIDUES 25 - 54; SYNONYM: INSULIN B CHAIN, INSULIN A CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNFLA 7 WASTRES 8 QQYFRYRT 5 AYGVN 16 MIWGDGNTDYNSALKS 10 DPYGSKPMDY crystal 3.50A 26.50% FAB 15-JAN-14 20140115 HYDROLASE / ANTIBODY CRYSTAL STRUCTURE OF FAB DX - 2930 IN COMPLEX WITH HUMAN PLASMA KALLIKREIN AT 2.4 ANGSTROM RESOLUTION MOLECULE: PLASMA KALLIKREIN; FRAGMENT: UNP RESIDUES 391 - 631; SYNONYM: FLETCHER FACTOR, KININOGENIN, PLASMA PREKALLIKREIN, PLASMA KALLIKREIN HEAVY CHAIN, PLASMA KALLIKREIN LIGHT CHAIN; EC: 3.4.21.34; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASTLES 8 QQYNTYWT 5 HYIMM 17 GIYSSGGITVYADSVKG 13 RRIGVPRRDEFDI crystal 2.40A 18.80% FAB 16-JAN-14 20140116 HYDROLASE / ANTIBODY CRYSTAL STRUCTURE OF FAB DX - 2930 IN COMPLEX WITH HUMAN PLASMA KALLIKREIN AT 2.1 ANGSTROM RESOLUTION MOLECULE: PLASMA KALLIKREIN; FRAGMENT: UNP RESIDUES 391 - 631; SYNONYM: FLETCHER FACTOR, KININOGENIN, PLASMA PREKALLIKREIN, PLASMA KALLIKREIN HEAVY CHAIN, PLASMA KALLIKREIN LIGHT CHAIN; EC: 3.4.21.34; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASTLES 8 QQYNTYWT 1 M 17 GIYSSGGITVYADSVKG 13 RRIGVPRRDEFDI crystal 2.10A 18.50% FAB 16-JAN-14 20140116 VIRAL PROTEIN / IMMUNE SYSTEM WEST NILE VIRUS NS1 IN COMPLEX WITH NEUTRALIZING 22NS1 ANTIBODY FAB MOLECULE: NON - STRUCTURAL PROTEIN NS1; FRAGMENT: UNP RESIDUES 963 - 1143; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 QHFWSTPRT 5 SYWMH 17 DINPNNGGPSYNEKFKR 8 DDGYRFGY crystal 3.00A 21.60% FAB 19-JAN-14 20140119 IMMUNE SYSTEM HUMANISED 3D6 FAB COMPLEXED TO AMYLOID BETA 1 - 8 MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: UNP RESIDUES 672 - 679; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 NYGMS 17 SIRSGGGRTYYSDNVKG 10 YDHYSGSSDY crystal 2.00A 17.40% FAB 21-JAN-14 20140121 BLOOD CLOTTING CRYSTAL STRUCTURE OF ANOPHELINE ANTI - PLATELET PROTEIN WITH FAB ANTIBODY MOLECULE: ANTI - PLATELET AGGREGATION PROTEIN; FRAGMENT: UNP RESIDUES 201 - 266; SYNONYM: GE RICH SALIVARY GLAND PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPYT 5 SYWMN 17 LIDPSDSETHYNQMFKD 4 GGTY crystal 1.80A 22.00% FAB 23-JAN-14 20140123 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRGGAVSYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.20A 20.10% ? 25-JAN-14 20140125 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 - G54F IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRFGAVSYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.50A 20.60% ? 25-JAN-14 20140125 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 - G54H IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRHGAVSYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.71A 20.10% ? 25-JAN-14 20140125 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 - G54L IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRLGAVSYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.20A 20.30% ? 25-JAN-14 20140125 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 - G54R IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRGGAVSYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.35A 20.40% ? 25-JAN-14 20140125 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 - G54W IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRWGAVSYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.10A 20.60% ? 25-JAN-14 20140125 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 - G54Y IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRYGAVSYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.29A 19.40% ? 25-JAN-14 20140125 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY VRC07 - I30Q, G54W, S58N IN COMPLEX WITH CLADE A / E 93TH057 HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 NCPIN 17 WMKPRWGAVNYARQLQG 16 GKYCTARDYYNWDFEH crystal 2.13A 19.20% ? 25-JAN-14 20140125 IMMUNE SYSTEM FAB FRAGMENT OF 3D6 IN COMPLEX WITH AMYLOID BETA 1 - 7 MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: UNP RESIDUES 672 - 678; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 NYGMS 17 SIRSGGGRTYYSDNVKG 10 YDHYSGSSDY crystal 2.00A 16.00% FAB 28-JAN-14 20140128 IMMUNE SYSTEM FAB FRAGMENT OF 3D6 IN COMPLEX WITH AMYLOID BETA 1 - 40 MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: UNP RESIDUES 672 - 711; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPRT 5 NYGMS 17 SIRSGGGRTYYSDNVKG 8 YDSGSSDY crystal 2.20A 18.00% FAB 28-JAN-14 20140128 MEMBRANE PROTEIN / IMMUNE SYSTEM LINGO - 1 / LI81 FAB COMPLEX MOLECULE: LEUCINE - RICH REPEAT AND IMMUNOGLOBULIN - LIKE DOMAIN - CONTAINING NOGO RECEPTOR - INTERACTING PROTEIN 1; FRAGMENT: UNP RESIDUES 40 - 517; SYNONYM: LEUCINE - RICH REPEAT AND IMMUNOGLOBULIN DOMAIN - CONTAINING PROTEIN 1, LEUCINE - RICH REPEAT NEURONAL PROTEIN 1, LEUCINE - RICH REPEAT NEURONAL PROTEIN 6A; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 10 QQRSNWPMYT 5 AYEMK 17 VIGPSGGFTFYADSVKG 9 EGDNDAFDI crystal 3.23A 19.50% FAB 10-FEB-14 20140210 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.04, A POTENT V1V2 - DIRECTED HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGSSSNIGNNFVS 7 ETNKRPS 9 ATWLTSARV 5 RYGMH 19 AISYDGTDKYHADKVWGRF 26 DLREDECEEWWSDLPCRKSRGVAGIF crystal 3.12A 27.60% FAB 11-FEB-14 20140211 TRANSFERASE / APOPTOSIS / IMMUNE SYSTEM HIV - 1 NEF PROTEIN IN COMPLEX WITH SINGLE DOMAIN ANTIBODY SDAB19 AND AN ENGINEERED HCK SH3 DOMAIN MOLECULE: PROTEIN NEF; FRAGMENT: NEF PROTEIN, UNP RESIDUES 45 - 210; SYNONYM: 3'ORF, NEGATIVE FACTOR, F - PROTEIN, C - TERMINAL CORE PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TSNMA 16 LITISGYTDYADSVKD 8 RVGSEYDL crystal 2.00A 20.40% HC-dimer 12-FEB-14 20140212 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HCMV GB - NEUTRALIZING SM5 - 1 FAB FRAGMENT ? ? ? HOMO SAPIENS 13 SGSSSNIGKNYVS 7 DNNKRPS 10 GTPDRSLSVI 5 DHYMV 17 WINPQSGGTGYGQKFQG 19 DGAKTVSNSLLYYHNRLDA crystal 1.87A 19.10% FAB 13-FEB-14 20140213 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURAL BASIS FOR THE RECOGNITION OF HUMAN CYTOMEGALOVIRUS GLYCOPROTEIN B BY THE NEUTRALIZING HUMAN ANTIBODY SM5 - 1 MOLECULE: ENVELOPE GLYCOPROTEIN B; FRAGMENT: UNP RESIDUES 113 - 133, 344 - 438; SYNONYM: GB, GLYCOPROTEIN GP55; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: 4 - RESIDUE LINKER BETWEEN A133 AND A344; ? ? HOMO SAPIENS 13 SGSSSNIGKNYVS 7 DNNKRPS 10 GTPDRSLSVV 5 DHYMV 17 WINPQSGGTGYGQKFQG 22 DGAKTVSNSGLSLLYYHNRLDA crystal 2.11A 17.40% FAB 13-FEB-14 20140213 IMMUNE SYSTEM STRUCTURE OF THE ANTI - FRANCISELLA TULARENSIS O - ANTIGEN ANTIBODY N203 FAB FRAGMENT ? ? ? MUS MUSCULUS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDYSYPLT 5 SYWMQ 17 AIYPGDGDTRYTQKFKG 4 RWDY crystal 2.10A 19.40% FAB 14-FEB-14 20140214 IMMUNE SYSTEM ANTI - BLA G 1 SCFV ? ? ? GALLUS GALLUS 17 ETVKITCSGGGSSSNYG 7 YNNNNRP 15 CGGRDSTYAGMFGAG 2 SS 13 APVTVIYNNNNRP 26 CGGRDSTYAGMFGAGTTLTVLAVTLD crystal 1.80A 16.60% scFv 18-FEB-14 20140218 HYDROLASE ANTI - MT1 - MMP MONOCLONAL ANTIBODY MOLECULE: ANTI_MT1 - MMP HEAVY CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHAPYT 5 NYAMS 17 TISGGGRNIYSLDSVKG 9 ENYGSSFTY crystal 2.60A 19.90% ? 19-FEB-14 20140219 IMMUNE SYSTEM X - RAY STRUCTURE OF THE DC8E8 FAB APO - FORM CRYSTALLIZED AT PH 8.5 AND REFINED TO 3.0 A. ? ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 3.00A 22.80% FAB 13-FEB-14 20140213 TOXIN COMPLEX OF SHIGA TOXIN 2E WITH A NEUTRALIZING SINGLE - DOMAIN ANTIBODY MOLECULE: SHIGA TOXIN 2E, SUBUNIT B; SYNONYM: SLT - IIEB, SHIGA TOXIN 2 VARIANT E B - SUBUNIT, SHIGA TOXIN 2B SUBUNIT, SHIGA TOXIN 2E B, SHIGA TOXIN 2E SUBUNIT B, SHIGA - LIKE TOXIN 2B - SUBUNIT, SHIGA - LIKE TOXIN IIE VARIANT SUBUNIT B, SLT - IIVB, VEROTOXIN 2E SUBUNIT B; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LSTMG 16 SITSYGDTNYRDSVKG 14 NIEAGTYYGPGRDY crystal 2.82A 19.00% HC-dimer 18-FEB-14 20140218 IMMUNE SYSTEM MT1 - MMP:FAB COMPLEX (FORM I) MOLECULE: MATRIX METALLOPROTEINASE - 14; SYNONYM: MMP - 14, MMP - X1, MEMBRANE - TYPE MATRIX METALLOPROTEINASE 1, MTMMP1, MEMBRANE - TYPE - 1 MATRIX METALLOPROTEINASE, MT1MMP; EC: 3.4.24.80; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHAPYT 5 NYAMS 17 TISGGGRNIYSLDSVKG 9 ENYGSSFTY crystal 1.94A 15.60% FAB 06-MAR-14 20140306 IMMUNE SYSTEM MT1 - MMP:FAB COMPLEX (FORM II) MOLECULE: MATRIX METALLOPROTEINASE - 14; FRAGMENT: MT1 - MMP V - B LOOP; SYNONYM: MMP - 14, MMP - X1, MEMBRANE - TYPE MATRIX METALLOPROTEINASE 1, MTMMP1, MEMBRANE - TYPE - 1 MATRIX METALLOPROTEINASE, MT1MMP; EC: 3.4.24.80; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHAPYT 5 NYAMS 17 TISGGGRNIYSLDSVKG 9 ENYGSSFTY crystal 1.95A 16.10% FAB 07-MAR-14 20140307 IMMUNE SYSTEM THE STRUCTURE OF A CHICKEN ANTI - CARDIAC TROPONIN I SCFV ? ? ? GALLUS GALLUS 14 SGGGRYYDGSYYYG 7 YENTKRP 12 CGSADDNMNPTI 7 GSYYYGW 13 TVIYENTKRPSNI 26 ADDNMNPTIFGAGTTLTVLGALTLDE crystal 1.35A 15.70% scFv 12-MAR-14 20140312 IMMUNE SYSTEM THE STRUCTURE OF A CHICKEN ANTI - PROSTATE SPECIFIC ANTIGEN SCFV ? ? ? GALLUS GALLUS 8 SGSSGSYG 7 YQSNQRP 15 CGGWGSSVGMFGAGT 0 13 TVIYQSNQRPSDI 26 WGSSVGMFGAGTTLTVLGAVTLDESG crystal 1.40A 18.50% scFv 12-MAR-14 20140312 SIGNALING PROTEIN, IMMUNE SYSTEM HER3 EXTRACELLULAR DOMAIN IN COMPLEX WITH FAB FRAGMENT OF MOR09825 MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 3; SYNONYM: PROTO - ONCOGENE - LIKE PROTEIN C - ERBB - 3,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER3; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISNWLA 7 GASSLQS 9 QQYSSFPTT 5 SYAMS 17 AINSQGKSTYYADSVKG 8 WGDEGFDI crystal 3.40A 18.70% FAB 15-MAR-14 20140315 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF 8ANC195 FAB IN COMPLEX WITH GP120 OF 93TH057 HIV - 1 AND SOLUBLE CD4 D1D2 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: CD4 D1D2; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDKWSGLHHDGVMAFSS crystal 3.00A 23.70% FAB 04-APR-14 20140404 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 8ANC195 FAB MOLECULE: 8ANC195 LIGHT CHAIN; FRAGMENT: 8ANC195 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDKWSGLHHDGVMAFSS crystal 2.13A 21.20% FAB 04-APR-14 20140404 IMMUNE SYSTEM STRUCTURE OF THE FAB FRAGMENT OF THE ANTI - FRANCISELLA TULARENSIS GROEL ANTIBODY AB53 MOLECULE: AB53 HEAVY CHAIN; ? ? MUS MUSCULUS 16 KSSQSLLDSDGGTYLN 7 LVSKLDS 9 WQGAHFPYT 5 IFWMN 19 EVRLKSNNYATHYAESVKG 10 GYYGSNYGEY crystal 2.50A 21.40% FAB 10-APR-14 20140410 IMMUNE SYSTEM STRUCTURE OF THE FAB FRAGMENT OF THE ANTI - FRANCISELLA TULARENSIS GROEL ANTIBODY AB64 MOLECULE: AB64 HEAVY CHAIN; ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPYT 5 DYNMY 17 YIDPYNGDASYNQKFKG 13 TGYYYGRSYAMDY crystal 2.60A 19.10% FAB 11-APR-14 20140411 FLUORESCENT PROTEIN CRYSTAL STRUCTURE OF VSFGFP - 0 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: AEQUOREA VICTORIA, VICUGNA PACOS; ORGANISM_COMMON: JELLYFISH, ALPACA; ORGANISM_TAXID: 6100, 30538; GENE: GFP; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_CELL_LINE: TOP10; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBAD33 0 0 0 0 0 0 crystal 2.60A 20.10% Nanobody-fused 29-APR-14 20140429 IMMUNE SYSTEM / HYDROLASE HUMAN HEAVY - CHAIN DOMAIN ANTIBODY IN COMPLEX WITH HEN EGG - WHITE LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C,ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 3 DMG 17 SIYGPSGSTYYADSVKG 12 YTSPPQNHGFDY crystal 2.60A 22.80% HC-dimer 02-MAY-14 20140502 TRANSPORT PROTEIN X - RAY STRUCTURE OF THE MOUSE SEROTONIN 5 - HT3 RECEPTOR MOLECULE: 5 - HYDROXYTRYPTAMINE RECEPTOR 3A; SYNONYM: 5 - HT3A,5 - HYDROXYTRYPTAMINE RECEPTOR 3,5 - HT3R,SEROTONIN RECEPTOR 3A,SEROTONIN - GATED ION CHANNEL RECEPTOR; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 ILRMDWY 19 TRDAAGYADSTNYADSVKG 11 DARTITGRADY crystal 3.50A 21.90% HC-dimer 09-MAY-14 20140509 VIRAL PROTEIN / IMMUME SYSTEM HEPATITIS E VIRUS E2S DOMAIN (GENOTYPE IV) IN COMPLEX WITH A NEUTRALIZING ANTIBODY 8G12 MOLECULE: CAPSID PROTEIN; FRAGMENT: E2S DOMAIN, UNP RESIDUES 93 - 240; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSNLV 7 AATNLPD 9 QHFWETPFT 5 DFNMH 17 YIYPYNGITGQNQKFKS 14 ERFGVGNNYAWFTY crystal 2.30A 18.90% ? 18-MAY-14 20140518 VIRAL PROTEIN / IMMUNE SYSTEM HEPATITIS E VIRUS E2S DOMAIN (GENOTYPE I) IN COMPLEX WITH A NEUTRALIZING ANTIBODY 8G12 MOLECULE: CAPSID PROTEIN; FRAGMENT: E2S DOMAIN, UNP RESIDUES 8 - 152; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSNLV 7 AATNLPD 9 QHFWETPFT 5 DFNMH 17 YIYPYNGITGQNQKFKS 14 ERFGVGNNYAWFTY crystal 4.00A 26.60% ? 18-MAY-14 20140518 HYDROLASE / IMMUNE SYSTEM VHH - METAL IN COMPLEX WITH RNASE A MOLECULE: RIBONUCLEASE PANCREATIC; SYNONYM: RNASE 1, RNASE A; EC: 3.1.27.5; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YLHMG 19 VAAMDSGGGGTLYADSVKG 12 GGYQLRDRTYGH crystal 1.75A 18.50% HC-dimer 26-FEB-14 20140226 IMMUNE SYSTEM ENGINEERED DUAL SPECIFIC VHH ANTIBODY ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YLHMG 19 VAAMDSGGGGTLYADSVKG 12 GGYQLRDRTYGH crystal 1.50A 20.30% HC-dimer 26-FEB-14 20140226 IMMUNE SYSTEM FAB FRAGMENT OF DER P 1 SPECIFIC ANTIBODY 10B9 ? ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPYT 5 SGFWN 16 YITYSGTSYYKPSLKS 14 RGFLTTVNYYAMDY crystal 1.75A 17.10% FAB 26-FEB-14 20140226 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 5H8 MOLECULE: PEPTIDASE 1; SYNONYM: ALLERGEN DER P I, MAJOR MITE FECAL ALLERGEN DER P 1; EC: 3.4.22.65; ? ? MUS MUSCULUS 11 RASQDITNYLN 7 YTSRLHS 8 QQGKTLPT 5 GYGVN 16 MIWGDGRIDYNLVRKS 12 AYQRYDYYAMDY crystal 3.00A 22.10% FAB 26-FEB-14 20140226 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 10B9 MOLECULE: PEPTIDASE 1; SYNONYM: ALLERGEN DER P I, MAJOR MITE FECAL ALLERGEN DER P 1; EC: 3.4.22.65 ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPYT 5 SGFWN 16 YITYSGTSYYKPSLKS 14 RGFLTTVNYYAMDY crystal 2.74A 20.30% FAB 26-FEB-14 20140226 IMMUNE SYSTEM ENGINEERED DUAL SPECIFIC VHH ANTIBODY IN COMPLEX WITH A NICKEL (II) ION ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YLHMG 19 VAAMDSGGGGTLYADSVKG 12 GGYELRDRTYGH crystal 1.50A 19.40% HC-dimer 27-FEB-14 20140227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL - 13 AND M1295 FAB MOLECULE: INTERLEUKIN - 13; FRAGMENT: UNP RESIDUES 35 - 146; SYNONYM: IL - 13; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASKSISKYLA 7 SGSTLQS 8 QQHDYPYT 7 TYGVGVG 16 HIWWDDVKRYNPALKS 11 LGSDYDVWFDY crystal 2.80A 21.40% FAB 06-MAR-14 20140306 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - 23F STREP FAB C05 ? ? ? HOMO SAPIENS 11 RASQSVGTYLA 7 DASRRAT 11 QHRDSWPPGAT 5 SHGMH 17 VIASHGNVNYYADSVKG 16 ESDSCGGDCSRFAFDV crystal 1.80A 17.20% FAB 11-MAR-14 20140311 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - 23F STREP FAB C05 WITH RHAMNOSE ? ? ? HOMO SAPIENS 11 RASQSVGTYLA 7 DASRRAT 11 QHRDSWPPGAT 5 SHGMH 17 VIASHGNVNYYADSVKG 16 ESDSCGGDCSRFAFDV crystal 1.51A 18.00% FAB 11-MAR-14 20140311 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB DX - 2930 MOLECULE: DX - 2930 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASTLES 8 QQYNTYWT 1 M 15 GIYGGITVYADSVKG 9 RRIRDEFDI crystal 1.75A 17.40% FAB 12-MAR-14 20140312 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 3.1 ? ? ? HOMO SAPIENS 11 RASQGISSWLA 7 AASSLQS 9 QQANSFPLT 5 MYATH 17 LISYDGSNKYYADSVKG 13 DLGGYFIRGIMDV crystal 2.70A 23.00% FAB 26-MAR-14 20140326 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 3.1 IN COMPLEX WITH THE 1918 INFLUENZA VIRUS HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: MEMBRANE FUSION SUBUNIT (UNP RESIDUES 345 - 520); ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISSWLA 7 AASSLQS 9 QQANSFPLT 5 MYATH 17 LISYDGSNKYYADSVKG 13 DLGGYFIRGIMDV crystal 2.91A 19.60% FAB 26-MAR-14 20140326 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF NON - NEUTRALIZING ANTIBODY IN COMPLEX WITH EPITOPE II OF HCV E2 MOLECULE: ENVELOPE GLYCOPROTEIN E2; FRAGMENT: EPITOPE II (UNP RESIDUES 421 - 446); SYNONYM: NS1, GP68, GP70 ? ? MUS MUSCULUS 16 RSSQSIVHNNGNTYLD 7 KVSNRFS 9 FQGSHVPPT 5 SYYIH 17 WIYPGNVNTKYNEKFKG 10 DDYDGAWFAY crystal 2.90A 22.40% FAB 02-APR-14 20140402 IMMUNE SYSTEM FAB FRAGMENT OF HIV VACCINE - ELICITED CD4BS - DIRECTED ANTIBODY, GE356, FROM A NON - HUMAN PRIMATE ? ? ? MACACA MULATTA 13 TGSSSNIGGYDVH 7 DNNERPS 11 QSYDSSLNAWV 5 DYYMH 17 QINPKTGGTNYAQKFQG 15 GGQRLLLLRNYYFYY crystal 1.93A 23.40% FAB 10-APR-14 20140410 HYDROLASE CRYSTAL STRUCTURE ANALYSIS OF FAB - BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INSULIN MOLECULE: INSULIN - DEGRADING ENZYME; SYNONYM: ABETA - DEGRADING PROTEASE, INSULIN PROTEASE, INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSVSSAVA 7 STSSLYS 10 QQSSPSFLIT 5 SYSIH 17 SISSYYGSTSYADSVKG 20 DRVMYYWSFSKYGYPYGMDY crystal 3.93A 24.70% FAB 18-APR-14 20140418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MURINE 2D5 FAB, A POTENT ANTI - CD4 HIV - 1 - NEUTRALIZING ANTIBODY IN COMPLEX WITH CD4 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASQSVSTSRYSYMH 7 YASNLES 9 QHSWEIPYT 5 DYSMH 17 RINTETGEAKYVDDFMG 11 YDGYSWDAMDY crystal 3.65A 22.80% FAB 22-APR-14 20140422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A CHEMOENZYMATIC GLYCOENGINEERED DISIALYLATED FC (DI - SFC) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293-6E 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.00A 26.00% FC 23-APR-14 20140423 IMMUNE SYSTEM F241A FC ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293-6E; EXPRESSION_SYSTEM_PLASMID: PCDNA3.1 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.19A 20.60% FC 24-APR-14 20140424 IMMUNE SYSTEM WILD TYPE FC (WTFC) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293-6E 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.35A 21.10% FC 24-APR-14 20140424 IMMUNE SYSTEM IGNAR ANTIBODY DOMAIN C1 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21 STAR (DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET28A 0 0 0 0 0 0 crystal 2.40A 26.60% NAR 29-APR-14 20140429 IMMUNE SYSTEM IGNAR ANTIBODY DOMAIN C2 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21 STAR (DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET28A 0 0 0 0 0 0 crystal 1.50A 18.20% NAR 30-APR-14 20140430 IMMUNE SYSTEM IGNAR ANTIBODY DOMAIN C3 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GINGLYMOSTOMA CIRRATUM; ORGANISM_COMMON: NURSE SHARK; ORGANISM_TAXID: 7801; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21 STAR (DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET28A Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 26.00% NAR 30-APR-14 20140430 RNA CRYSTAL STRUCTURE OF AN RNA APTAMER BOUND TO BROMO - LIGAND ANALOG IN COMPLEX WITH FAB MOLECULE: SPINACH RNA APTAMER; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.45A 18.40% scFv 01-MAY-14 20140501 RNA / IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN RNA APTAMER BOUND TO TRIFLUOROETHYL - LIGAND ANALOG IN COMPLEX WITH FAB MOLECULE: SPINACH RNA APTAMER; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 3.12A 20.60% scFv 01-MAY-14 20140501 CYTOKINE / CYTOKINE RECEPTOR PDGF - B BLOCKING ANTIBODY BOUND TO PDGF - BB MOLECULE: PLATELET - DERIVED GROWTH FACTOR SUBUNIT B; SYNONYM: PDGF SUBUNIT B, PDGF - 2, PLATELET - DERIVED GROWTH FACTOR B CHAIN, PLATELET - DERIVED GROWTH FACTOR BETA POLYPEPTIDE, PROTO - ONCOGENE C - SIS; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDSLGSYFVH 7 DDSNRPS 9 SAFTHNSDV 5 SYAMS 17 YISDDGSLKYYADSVKG 11 HPYWYGGQLDL crystal 2.30A 21.30% ? 12-MAY-14 20140512 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFEBA - 175 RII IN COMPLEX WITH A FAB FRAGMENT FROM INHIBITORY ANTIBODY R217 MOLECULE: ERYTHROCYTE - BINDING ANTIGEN - 175; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASKGVDSYGNSFMH 7 LASHLES 9 QQNNEDPFT 5 ENTMH 17 GINTDNGGTTYSQKFKG 7 GYDAMDY crystal 4.50A 23.50% FAB 19-MAY-14 20140519 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNLIGANDED CH59UA, THE INFERRED UNMUTATED ANCESTOR OF THE RV144 ANTI - HIV ANTIBODY LINEAGE PRODUCING CH59 ? ? ? HOMO SAPIENS 11 SGDALPKKYAY 7 EDSKRPS 11 YSTDSSGNHRV 5 DYAMH 17 GISWNSGSIGYADSVKG 11 DSPRGELPFDY crystal 2.40A 18.40% FAB 19-MAY-14 20140519 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF HUMAN IGG FC DOMAIN WITH ENHANCED AROMATIC SEQUON ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.99A 29.90% FC 25-MAY-14 20140525 IMMUNE SYSTEM CAMELID (LLAMA) NANOBODY N25 (VHH) AGAINST TYPE 6 SECRETION SYSTEM TSSM PROTEIN MOLECULE: NANOBODY N25, VH DOMAIN; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAIG 17 CISNLDGSTYYPDSVKG 17 VNAQCTDYIIGPYGMDY crystal 1.38A 19.20% HC-dimer 26-MAY-14 20140526 IMMUNE SYSTEM UCA (UNBOUND) FROM CH103 LINEAGE ? ? ? HOMO SAPIENS 11 SGDKLGDKYAC 7 QDSKRPS 10 QAWDSFSTFV 5 SYYWS 16 YIYYSGSTNYNPSLKS 13 LPRGQLVNAYFDY crystal 3.49A 27.00% FAB 28-MAY-14 20140528 IMMUNE SYSTEM I3.2 (UNBOUND) FROM CH103 LINEAGE ? ? ? HOMO SAPIENS 11 SGDKLGDKYAC 7 QDSKRPS 10 QAWDSFSTFV 5 GYYWS 16 YIFHTGHTNYNPSLES 13 LPRGQLVNAFFDN crystal 3.15A 23.90% FAB 28-MAY-14 20140528 IMMUNE SYSTEM I3.1 (UNBOUND) FROM CH103 LINEAGE ? ? ? HOMO SAPIENS 11 SGDKVASKNVC 7 ENYKRPS 10 QVWDSFSTFV 5 GYYWS 16 YIFHTGHTNYNPSLES 13 LPRGQLVNAFFDN crystal 3.23A 22.60% FAB 28-MAY-14 20140528 IMMUNE SYSTEM I2 (UNBOUND) FROM CH103 LINEAGE ? ? ? HOMO SAPIENS 11 SGDKVASKNVC 7 ENYKRPS 10 QVWDSFSTFV 5 GTYWS 16 YIFHTGHTNYNPSLEG 13 LPRGQLVNAYFRN crystal 3.00A 22.80% FAB 28-MAY-14 20140528 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IL - 17A / FAB6785 COMPLEX MOLECULE: INTERLEUKIN - 17A; SYNONYM: IL - 17, IL - 17A, CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8, CTLA - 8; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 SGDNLGDKYAN 7 DDIDRPS 11 GSYDFFLGMIV 5 SYAMS 17 TISLTSGFTYYADSVKG 6 QLTLDV crystal 2.20A 17.30% FAB 29-MAY-14 20140529 MEMBRANE PROTEIN / IMMUNE SYSTEM STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO A COVALENT AGONIST AND AN ENGINEERED NANOBODY MOLECULE: BETA - 2 ADRENERGIC RECEPTOR; SYNONYM: BETA - 2 ADRENORECEPTOR, BETA - 2 ADRENOCEPTOR; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 3.30A 24.00% HC-dimer 10-JUN-14 20140610 IMMUNE SYSTEM LLAMA NANOBODY N02 RAISED AGAINST EAEC T6SS TSSM MOLECULE: LLAMA NANOBODY N02 VH DOMAIN; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYALG 17 AISWSGGSTYYADSVQG 15 DKYYTGPGGESVYDY crystal 1.70A 20.80% HC-dimer 13-JUN-14 20140613 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 2009 PANDEMIC H1N1 INFLUENZA VIRUS NEURAMINIDASE WITH A NEUTRALIZING ANTIBODY MOLECULE: NEURAMINIDASE; FRAGMENT: UNP RESIDUES 82 - 467; EC: 3.2.1.18; ENGINEERED: YES; ? ? MUS MUSCULUS 10 RTSSSVSYMH 7 ATSNLAS 9 QQWNSNPPT 5 TYAMN 19 RIRSKSNNYATFYADSVKD 13 PSIYYYASGYLDV crystal 2.80A 18.30% FAB 18-JUN-14 20140618 APOPTOSIS, TRANSCRIPTION P53 DNA BINDING DOMAIN IN COMPLEX WITH NB139 MOLECULE: CELLULAR TUMOR ANTIGEN P53; FRAGMENT: P53DBD, UNP RESIDUES 92 - 312; SYNONYM: ANTIGEN NY - CO - 13, PHOSPHOPROTEIN P53, TUMOR SUPPRESSOR P53; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYAMG 17 QINWSGTTTYYAESVKD 14 HPQRGWGSTLGWTY crystal 1.92A 16.70% HC-dimer 19-JUN-14 20140619 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 3BD10: A MONOCLONAL ANTIBODY AGAINST THE TSH RECEPTOR ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKVDS 9 WQGTHSPLT 5 NYWMN 17 RIDPSDSETHYNQNFKD 3 SGY crystal 2.50A 23.80% ? 07-JUL-14 20140707 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - UPAR FAB 8B12 ? ? ? MUS MUSCULUS 11 RASQDIGSSLN 7 ATSSLDS 9 LQYATSPYT 5 AYWIE 17 EILPGSSSTNCNEMFKG 13 DFSGDRSNLYFDV crystal 2.17A 23.10% FAB 08-JUL-14 20140708 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN UPAR IN COMPLEX WITH ANTI - UPAR FAB 8B12 MOLECULE: UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR; SYNONYM: U - PAR, UPAR, MONOCYTE ACTIVATION ANTIGEN MO3; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDIGSSLN 7 ATSSLDS 9 LQYATSPYT 5 AYWIE 17 EILPGSSSTNCNEMFKG 13 DFSGDRSNLYFDV crystal 3.00A 25.20% FAB 08-JUL-14 20140708 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB410 - BFACHE COMPLEX MOLECULE: ACETYLCHOLINESTERASE; FRAGMENT: UNP RESIDUES 32 - 566; SYNONYM: ACHE; EC: 3.1.1.7; ? ? MUS MUSCULUS 10 SASSSVSYMY 7 RTSNLAS 9 QQYNSHPMT 5 TYAMH 19 RIRSKSNKYATHYADSVKD 14 EGSYYDSSYGAMDY crystal 2.70A 20.10% FAB 17-JUL-14 20140717 IMMUNE SYSTEM ANTIGEN BINDING FRAGMENT OF AN ANTI IFNAR1 ANTIBODY ? ? IGG1 HOMO SAPIENS 12 RASQSVSSSFFA 7 GASSRAT 9 QQYDSSAIT 5 NYWIA 17 IIYPGDSDIRYSPSFQG 8 HDIEGFDY crystal 2.30A 19.30% FAB 20-JUL-14 20140720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MSP2 FV FRAGMENT (MAB6D8) IN COMPLEX WITH FC27 - MSP2 14 - 30 MOLECULE: MEROZOITE SURFACE ANTIGEN 2; FRAGMENT: UNP RESIDUES 33 - 49; SYNONYM: MEROZOITE SURFACE PROTEIN 2, MSA - 2; ENGINEERED: YES ? ? MUS MUSCULUS 15 KASQSVDHDGDSYMN 7 AASNLES 9 QQTNEDPYT 5 DDFIH 17 RIDPANGYTKYAPKFQD 5 YGVAY crystal 1.58A 15.70% FV 22-JUL-14 20140722 IMMUNE SYSTEM NOVEL INHIBITION MECHANISM OF MEMBRANE METALLOPROTEASE BY AN EXOSITE - SWIVELING CONFORMATIONAL ANTIBODY MOLECULE: MATRIX METALLOPROTEINASE - 14; FRAGMENT: PEPTIDE (UNP RESIDUES 218 - 228); SYNONYM: MMP - 14, MMP - X1, MEMBRANE - TYPE MATRIX METALLOPROTEINASE 1, MT - MMP 1, MTMMP1, MEMBRANE - TYPE - 1 MATRIX METALLOPROTEINASE, MT1 - MMP, MT1MMP; EC: 3.4.24.80; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHAPYT 5 NYAMS 17 TISGGGRNIYSLDSVKG 9 ENYGSSFTY crystal 2.30A 24.60% ? 22-JUL-14 20140722 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MSP2 FV FRAGMENT (MAB6D8) IN COMPLEX WITH 3D7 - MSP2 14 - 30 MOLECULE: MEROZOITE SURFACE ANTIGEN 2; FRAGMENT: UNP RESIDUES 33 - 49; SYNONYM: MEROZOITE SURFACE PROTEIN 2, MSA - 2, 45 KDA MEROZOITE SURFACE ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 15 KASQSVDHDGDSYMN 7 AASNLES 9 QQTNEDPYT 5 DDFIH 17 RIDPANGYTKYAPKFQD 5 YGVAY crystal 1.35A 15.20% FV 24-JUL-14 20140724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MSP2 FV FRAGMENT (MAB6D8) IN COMPLEX WITH MSP2 14 - 22 MOLECULE: MEROZOITE SURFACE ANTIGEN 2; FRAGMENT: UNP RESIDUES 33 - 41; SYNONYM: MEROZOITE SURFACE PROTEIN 2, MSA - 2; ENGINEERED: YES ? ? MUS MUSCULUS 15 KASQSVDHDGDSYMN 7 AASNLES 9 QQTNEDPYT 5 DDFIH 17 RIDPANGYTKYAPKFQD 5 YGVAY crystal 1.21A 15.20% FV 24-JUL-14 20140724 IMMUNE SYSTEM ANTI - CANINE CD28 ANTIBODY, 1C6, BOUND CANINE CD28 MOLECULE: T - CELL COSTIMULATORY MOLECULE CD28; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSTKSLLHSNGNTYLY 7 YMSNLAS 9 MQSLEYPYT 5 NYGMT 17 WINTYTGRPTYADDFKG 5 LGEDF crystal 3.30A 25.80% ? 31-JUL-14 20140731 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PGT124, A BROADLY NEUTRALIZING AND POTENT HIV - 1 NEUTRALIZING ANTIBODY MOLECULE: PGT124 - LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GRQALGSRAVQ 7 NNQDRPS 15 YYCHMWDSRSGFSWS 5 NYYWT 16 YISDRETTTYNPSLNS 24 ARRGQRIYGVVSFGEFFYYYYMDV crystal 2.50A 23.50% FAB 08-AUG-14 20140808 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PGT124 FAB BOUND TO HIV - 1 JRCSF GP120 CORE AND TO CD4 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GRQALGSRAVQ 7 NNQDRPS 15 YYCHMWDSRSGFSWS 5 NYYWT 16 YISDRETTTYNPSLNS 24 ARRGQRIYGVVSFGEFFYYYYMDV crystal 3.28A 21.00% FAB 11-AUG-14 20140811 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MSP2 FV FRAGMENT (MAB6D8) IN COMPLEX WITH MSP2 11 - 23 MOLECULE: MEROZOITE SURFACE PROTEIN; FRAGMENT: 11 - 23; ENGINEERED: YES ? ? MUS MUSCULUS 15 KASQSVDHDGDSYMN 7 AASNLES 9 QQTNEDPYT 5 DDFIH 17 RIDPANGYTKYAPKFQD 5 YGVAY crystal 1.70A 15.40% FV 18-AUG-14 20140818 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - HIV - 1 ANTIBODY 2.2C ? ? ? HOMO SAPIENS 11 RASQGISSYLA 1 A 8 QHLIGLRS 5 GHYWS 16 EIKHNGSPNYHPSLKS 11 RSNWPYLPFDP crystal 2.20A 16.80% FAB 19-AUG-14 20140819 VIRAL PROTEIN / IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF NON - NEUTRALIZING, A32 - LIKE ANTIBODY 2.2C IN COMPLEX WITH HIV - 1 YU2 GP120 MOLECULE: M48U1 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 10 RASQGISYLA 7 AASTLQS 8 QHLIGLRS 5 GHYWS 16 EIKHNGSPNYHPSLKS 11 RSNWPYLPFDP crystal 3.51A 25.50% ? 19-AUG-14 20140819 VIRAL PROTEIN / IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF NON - NEUTRALIZING, A32 - LIKE ANTIBODY 2.2C IN COMPLEX WITH HIV - 1 ENV GP120 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: UNP RESIDUES 26 - 203; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISSYLA 7 AASTLQS 8 QHLIGLRS 5 GHYWS 16 EIKHNGSPNYHPSLKS 11 RSNWPYLPFDP crystal 4.28A 31.00% ? 19-AUG-14 20140819 VIRAL PROTEIN / IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF THE ANTI - HIV - 1 ANTIBODY 2.2C IN COMPLEX WITH HIV - 1 93UG037 GP120 MOLECULE: HIV - 1 GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISSYLA 7 AASTLQS 8 QHLIGLRS 4 HYWS 16 EIKHNGSPNYHPSLKS 11 RSNWPYLPFDP crystal 3.56A 29.70% ? 19-AUG-14 20140819 IMMUNE SYSTEM FAB HU 15C1 ? ? ? HOMO SAPIENS 11 RASQSISDHLH 7 YASHAIS 9 QQGHSFPLT 6 GGYSWH 16 YIHYSGYTDFNPSLKT 9 KDPSDAFPY crystal 2.75A 17.80% FAB 27-AUG-14 20140827 IMMUNE SYSTEM FAB C2E3 ? ? ? HOMO SAPIENS 11 RASQSISDHLH 7 YASHAIS 9 QQGYDFPLT 6 FGYSWH 16 YIHYSGYTDFNPSLKT 9 KDSGNYFPY crystal 3.45A 23.80% FAB 28-AUG-14 20140828 IMMUNE SYSTEM CRYSTAL STRUCTURE OF H7 HEMAGGLUTININ FROM A / ANHUI / 1 / 2013 IN COMPLEX WITH A NEUTRALIZING ANTIBODY CT149 MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 340 - 516; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASHRVGSTYIA 7 GASNRAT 9 QQFSVSPWT 5 TYGVS 17 WISAYTGITDYAQKFQG 17 DKVQGRVEVGSGGRHDY crystal 2.79A 26.50% ? 03-SEP-14 20140903 IMMUNE SYSTEM ANTI CD70 LLAMA GLAMA FAB 27B3 ? ? ? LLAMA GLAMA 14 GLKSGSVTSTNFPT 7 NTNTRHS 10 ALFISNPSVE 5 VYYMN 17 DINNEGGTTYYADSVKG 13 DAGYSNHVPIFDS crystal 1.75A 16.40% FAB 03-SEP-14 20140903 IMMUNE SYSTEM STRUCTURE OF A LLAMA GLAMA FAB 48A2 AGAINST HUMAN CMET ? ? ? LLAMA GLAMA 17 CKSSQSVLFSSNQKNYL 7 YWASIRE 10 CQQGYSFPYS 5 MNSID 17 RIDPEDGGTKYAQKFQG 10 VDDYYLGYDY crystal 3.31A 22.10% FAB 03-SEP-14 20140903 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF KKO ? ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRYS 9 QQYNSYPLT 5 NYFIY 17 EINPRNGDTDFNEKFES 11 SPYGNNYGFTY crystal 2.20A 20.30% FAB 03-SEP-14 20140903 IMMUNE SYSTEM / CYTOKINE CRYSTAL STRUCTURE OF KKOFAB IN COMPLEX WITH PLATELET FACTOR 4 MOLECULE: PLATELET FACTOR 4; SYNONYM: PF - 4, C - X - C MOTIF CHEMOKINE 4, IROPLACT, ONCOSTATIN - A, PLATELET FACTOR 4, SHORT FORM; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRYS 9 QQYNSYPLT 5 NYFIY 17 EINPRNGDTDFNEKFES 11 SPYGNNYGFTY crystal 4.11A 32.00% FAB 08-SEP-14 20140908 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RTOFAB IN COMPLEX WITH HUMAN PF4 MOLECULE: PLATELET FACTOR 4; SYNONYM: PF - 4, C - X - C MOTIF CHEMOKINE 4, IROPLACT, ONCOSTATIN - A, PLATELET FACTOR 4, SHORT FORM; ENGINEERED: YES ? ? MUS MUSCULUS 11 SASQGINNYLS 7 YTSSLHS 9 QQFSKLPYT 5 RYDMS 17 TITSGDNYTYYPDSVKG 10 QGLLYYAMDY crystal 3.74A 24.50% FAB 11-SEP-14 20140911 IMMUNE SYSTEM / APOPTOSIS CRYSTAL STRUCTURE OF SCFVC4 IN COMPLEX WITH THE FIRST 17 AA OF HUNTINGTIN MOLECULE: HUNTINGTIN; SYNONYM: HUNTINGTON DISEASE PROTEIN, HD PROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGTSSDIGAYNYVS 7 DVSNRPS 9 SSFANSGPL 5 SYSMS 17 VISYDGSNKYYADSVKG 6 DRYFDL crystal 2.50A 18.20% FV 11-SEP-14 20140911 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV NEUTRALIZING ANTIBODY 2G12 IN COMPLEX WITH A BACTERIAL OLIGOSACCHARIDE ANALOG OF MAMMALIAN OLIGOMANOSE WITH A BACTERIAL OLIGOSACCHARIDE ANALOG OF MAMMALIAN OLIGOMANOSE ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 1.85A 20.90% FAB 12-SEP-14 20140912 TRANSPORT PROTEIN CALCIUM - ACTIVATED CHLORIDE CHANNEL BESTROPHIN - 1, FROM CHICKEN, IN COMPLEX WITH FAB ANTIBODY FRAGMENTS, CHLORIDE AND CALCIUM MOLECULE: BESTROPHIN - 1; FRAGMENT: UNP RESIDUES 2 - 405; SYNONYM: BEST1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLT 7 NAKTLTE 9 QHHYGTPPT 5 NYWMH 17 MIDPSKSETTLNQKFRG 7 EVYYFDY crystal 2.85A 21.80% FAB 19-SEP-14 20140919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ADCC - POTENT ANTI - HIV - 1 RHESUS MACAQUE ANTIBODY JR4 FAB ? ? ? MACACA MULATTA 13 SGSSSNIGRSYVS 7 DTNKRPS 11 GAWDGSLNVHI 5 RNYWS 17 HSYGSGGSTNYNPSLES 14 TVWYYTSGTHYFDH crystal 1.91A 19.40% FAB 25-SEP-14 20140925 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ADCC - POTENT RHESUS MACAQUE ANTIBODY JR4 IN COMPLEX WITH HIV - 1 CLADE A / E GP120 AND M48 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4 MIMETIC M48; ENGINEERED: YES ? ? MACACA MULATTA 13 SGSSSNIGRSYVS 7 DTNKRPS 11 GAWDGSLNVHI 5 RNYWS 17 HSYGSGGSTNYNPSLES 14 TVWYYTSGTHYFDH crystal 3.21A 27.60% FAB 26-SEP-14 20140926 VIRAL PROTEIN / IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF THE ADCC - POTENT ANTIBODY N60 - I3 FAB IN COMPLEX WITH HIV - 1 CLADE A / E GP120 AND M48U1 MOLECULE: M48U1 CD4 MIMETIC PEPTIDE; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGGYKYVS 7 EVSNRPS 10 SSYTSSSTWV 7 SGGYFWS 16 NIYYIGNTYYNPSLKS 12 VPRLRGGNYFDS crystal 3.20A 22.30% FAB 26-SEP-14 20140926 TOXIN / IMMUNE SYSTEM STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN B BOUND TO THE NEUTRALIZING ANTIBODY 20B1 MOLECULE: ENTEROTOXIN TYPE B; FRAGMENT: UNP RESIDUES 28 - 266; SYNONYM: SEB, STAPHYLOCOCCAL ENTEROTOXIN B; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQEISDYLT 7 VASSLDS 9 LQYANYPWT 5 IAGIQ 17 WINTHSGVPEYAEEFKG 12 IYYGNNGGVMDY crystal 2.69A 22.80% FAB 30-SEP-14 20140930 TOXIN / IMMUNE SYSTEM STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN B BOUND TO TWO NEUTRALIZING ANTIBODIES, 14G8 AND 6D3 MOLECULE: ENTEROTOXIN TYPE B; FRAGMENT: UNP RESIDUES 28 - 266; SYNONYM: SEB, STAPHYLOCOCCAL ENTEROTOXIN B; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIGDYLH 7 YASQSIS 9 QNGHSFPYT 5 AYGLS 16 SISGGGSVYYPDSVKG 12 DLYGDYVGRYAY crystal 2.70A 24.20% FAB 30-SEP-14 20140930 TOXIN / IMMUNE SYSTEM STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN B BOUND TO THE NEUTRALIZING ANTIBODY 14G8 MOLECULE: ENTEROTOXIN TYPE B; FRAGMENT: UNP RESIDUES 28 - 266; SYNONYM: SEB, STAPHYLOCOCCAL ENTEROTOXIN B; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIGDYLH 7 YASQSIS 9 QNGHSFPYT 5 AYGLS 16 SISGGGSVYYPDSVKG 12 DLYGDYVGRYAY crystal 1.80A 14.40% FAB 30-SEP-14 20140930 IMMUNE SYSTEM STRUCTURAL ANALYSIS OF THE UNMUTATED ANCESTOR OF THE HIV - 1 ENVELOPE V2 REGION ANTIBODY CH58 ISOLATED FROM AN RV144 HIV - 1 VACCINE EFFICACY TRIAL VACCINEE AND ASSOCIATED WITH DECREASED TRANSMISSION RISK ? ? ? HOMO SAPIENS 13 TRSSGSIASNYVQ 7 EDNQRPS 11 YCQSYDSSSWV 5 SYWIG 17 IIYPGDSDTRYSPSFQG 17 LGGRYYYDSSGYYYFDY crystal 2.50A 22.40% FAB 07-OCT-14 20141007 IMMUNE SYSTEM STRUCTURAL ANALYSIS OF THE UNMUTATED ANCESTOR OF THE HIV - 1 ENVELOPE V2 REGION ANTIBODY CH58 ISOLATED FROM AN RV144 HIV - 1 VACCINE EFFICACY TRIAL VACCINEE AND ASSOCIATED WITH DECREASED TRANSMISSION RISK MOLECULE: ENVELOPE GLYCOPROTEIN; FRAGMENT: HIV - 1 GP120 DERIVED PEPTIDE (UNP RESIDUES 160 - 177); ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSIASNYVQ 7 EDNQRPS 11 YCQSYDSSSWV 5 SYWIG 17 IIYPGDSDTRYSPSFQG 17 LGGRYYYDSSGYYYFDY crystal 2.30A 17.00% FAB 07-OCT-14 20141007 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTI - HIV ANTIBODY PGT130 MOLECULE: PGT130 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 NGTSSDIGGWNFVS 7 EVNKRPS 10 SSLFGRWDVV 7 TGHYYWG 16 HIHYTTAVLHNPSLKS 9 SGKPHWFSP crystal 2.76A 24.50% ? 24-OCT-14 20141024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PGDM1400, A BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 16 KSSHSLIHGDRNNYLA 7 LASSRAS 9 MQGRESPWT 5 TYDLH 19 WISHEGDKKVIVERFKAKV 26 GSKHRLRDYALDDDGALNWAVDVDYL crystal 3.10A 22.30% FAB 04-NOV-14 20141104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FULLY GLYCOSYLATED HIV - 1 GP120 CORE BOUND TO CD4 AND 17B FAB MOLECULE: 2 - DOMAIN CD4; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 4.49A 27.90% FAB 05-NOV-14 20141105 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB COMPLEXED WITH ANTIGEN ASF1P, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET PDR16 MOLECULE: ANTIGEN ASF1P; ENGINEERED: YES ? ? HOMO SAPIENS 11 TCRASQSVSSA 7 IYSASSL 11 YCQQSQWYPIT 5 YSSIH 17 YIYPSSGYTSYADSVKG 10 SYSTKLAMDY crystal 2.79A 18.50% FAB 06-NOV-14 20141106 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF VH1 - 46 GERMLINE - DERIVED CD4 - BINDING SITE - DIRECTED ANTIBODY 8ANC131 IN COMPLEX WITH HIV - 1 CLADE B YU2 GP120 MOLECULE: HIV - 1 YU2 GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 10 RASQGLNFVV 7 APSGRAP 9 QEYSSTPYN 5 EFVIH 16 LIKRSGRLMTAYNFQD 16 DGLGEVAPDYRYGIDV crystal 2.13A 22.10% ? 08-DEC-14 20141208 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF VH1 - 46 GERMLINE - DERIVED CD4 - BINDING SITE - DIRECTED ANTIBODY 8ANC134 IN COMPLEX WITH HIV - 1 CLADE A Q842.D12 GP120 MOLECULE: HIV - 1 CLADE A Q842.D12 GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 10 RASQGLNFVV 7 GPTDRAP 9 QEYSSTPYN 5 EFVIH 16 LIKRSGRLMTSYKFQD 16 DGLGEVAPAYLYGIDA crystal 3.45A 21.00% ? 08-DEC-14 20141208 IMMUNE SYSTEM FV M6P - 1 IN COMPLEX WITH MANNOSE - 6 - PHOSPHATE WITH MANNOSE - 6 - PHOSPHATE ? ? LEPUS CURPAEUMS 12 QSSQSVYNNRLA 7 SASTLAS 10 HGGYRSDRYA 5 WYTMN 18 SIGAGVYGSNYYASWAKG 9 DGINGGYDI crystal 2.72A 22.80% FV 19-DEC-14 20141219 METAL BINDING PROTEIN / IMMUNE SYSTEM GELSOLIN NANOBODY SHIELDING MUTANT PLASMA GELSOLIN FROM FURIN PROTEOLYSIS MOLECULE: GELSOLIN; FRAGMENT: GELSOLIN DOMAIN 2; SYNONYM: AGEL, ACTIN - DEPOLYMERIZING FACTOR, ADF, BREVIN; ENGINEERED: YES; MUTATION: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SFVMG 17 SISRSGSVTRYADSAKG 18 DLHRPYGPGSQRTDDYDT crystal 2.61A 22.80% HC-dimer 07-JAN-15 20150107 IMMUNE SYSTEM GELSOLIN NANOBODY SHIELDING MUTANT PLASMA GELSOLIN FROM FURIN PROTEOLYSIS ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SFVMG 17 SISRSGSVTRYADSAKG 18 DLHRPYGPGSQRTDDYDT crystal 2.00A 16.10% HC-dimer 07-JAN-15 20150107 IMMUNE SYSTEM STRUCTURE OF IGG1 FAB FRAGMENT IN COMPLEX WITH BIOTINCYTIDINAMIDE WITH BIOTINCYTIDINAMIDE ? IGG1 MUS MUSCULUS 11 RASGNIHNYLS 7 SAKTLAD 9 QHFWSSIYT 5 DTFFQ 17 RIDPANGFTKYDPKFQG 11 WDTYGAAWFAY crystal 2.50A 22.80% FAB 13-JAN-15 20150113 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A VRC01 - LINEAGE ANTIBODY, 45 - VRC01.H03+06.D - 001739, IN COMPLEX WITH CLADE A / E HIV - 1 GP120 CORE MOLECULE: HIV - 1 GP120 CORE; FRAGMENT: RESIDUE 44 - 492; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 EYSIH 17 WIKGMWGAVSYARQLQG 26 SGDTAEYFCVRKGPSCPHCGDFHWQH crystal 2.40A 22.10% FAB 14-JAN-15 20150114 VIRAL PROTEIN / IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF A VRC01 - LINEAGE ANTIBODY, 45 - VRC01.H08.F - 117225, IN COMPLEX WITH CLADE A / E HIV - 1 GP120 CORE MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; FRAGMENT: RESIDUE 44 - 492; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 ESLIN 17 WINPRGGGVNYGRRFQG 23 GKSCCGGRRYCNGADCFNWDFEH crystal 3.21A 26.20% FAB 14-JAN-15 20150114 VIRAL PROTEIN / IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF A VRC01 - LINEAGE ANTIBODY, 45 - VRC01.H5.F - 185917, IN COMPLEX WITH CLADE A / E HIV - 1 GP120 CORE MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; FRAGMENT: RESIDUE 44 - 492; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 KYYLH 17 WINPRGGQVNYSRQFPG 16 TADCERDPCKGWVFPH crystal 3.39A 26.40% FAB 14-JAN-15 20150114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF MONOCLONAL ANTIBODY ROAB13 ? ? ? MUS MUSCULUS 17 KSSQSLLYRGNQMNYLA 7 WASTRES 9 QQYYTYPRT 5 TYAMS 16 SISTGDNTYYTDSVRG 11 GRGDRGDLFGY crystal 2.10A 18.90% FAB 22-JAN-15 20150122 TRANSPORT PROTEIN / IMMUNE SYSTEM C. ELEGANS GLUTAMATE - GATED CHLORIDE CHANNEL (GLUCL) IN COMPLEX WITH FAB IN A NON - CONDUCTING CONFORMATION MOLECULE: AVERMECTIN - SENSITIVE GLUTAMATE - GATED CHLORIDE CHANNEL GLUCL ALPHA; FRAGMENT: UNP RESIDUES 62 - 363,UNP RESIDUES 422 - 455; SYNONYM: PROTEIN GLC - 1; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSTGAVTTINFAN 7 GINNRAP 9 ALWYSNHWV 5 GYTMN 17 LINPYNGGTSYNQKFKG 13 DGDYYRYGRYFDY crystal 3.60A 26.20% FAB 05-JUN-14 20140605 TRANSPORT PROTEIN / IMMUNE SYSTEM C. ELEGANS GLUTAMATE - GATED CHLORIDE CHANNEL (GLUCL) IN COMPLEX WITH FAB AND POPC IN A LIPID - MODULATED CONFORMATION MOLECULE: AVERMECTIN - SENSITIVE GLUTAMATE - GATED CHLORIDE CHANNEL GLUCL ALPHA; FRAGMENT: UNP RESIDUES 62 - 363,UNP RESIDUES 422 - 455; SYNONYM: PROTEIN GLC - 1; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSTGAVTTINFAN 7 GINNRAP 9 ALWYSNHWV 5 GYTMN 17 LINPYNGGTSYNQKFKG 13 DGDYYRYGRYFDY crystal 3.20A 22.80% FAB 05-JUN-14 20140605 IMMUNE SYSTEM STRUCTURE OF 35O22 FAB, A HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 1.55A 16.70% FAB 06-JUN-14 20140606 IMMUNE SYSTEM STRUCTURE OF TAU5 ANTIBODY FAB FRAGMENT ? KAPPA ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPWT 5 DYYMH 17 WIDPENGDIAYAPKFQG 12 RGGMITTDFFDY crystal 1.60A 14.50% FAB 09-JUN-14 20140609 IMMUNE SYSTEM STRUCTURE OF TAU PEPTIDE IN COMPLEX WITH TAU5 ANTIBODY FAB FRAGMENT MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; FRAGMENT: RESIDUES 532 - 547; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES KAPPA ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPWT 5 DYYMH 17 WIDPENGDIAYAPKFQG 12 RGGMITTDFFDY crystal 1.60A 15.40% FAB 11-JUN-14 20140611 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN. ? ? ? MUS MUSCULUS 16 RSSQSLVHRNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 1 N 17 AIDPYYGGTSYNQKFKG 4 GMEY crystal 1.25A 15.10% ? 17-JUN-14 20140617 IMMUNE SYSTEM / HYDROLASE STRUCTURE OF A LYSOZYME FAB COMPLEX MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C,ALLERGEN GAL D IV; EC: 3.2.1.17; ? ? HOMO SAPIENS 14 TGRSSNIGAGYDVH 7 GNTNRPS 11 QSYDSSLSGSV 5 SNYMS 16 VIYSGGSTYYADSVKG 9 EGPGDSIDY crystal 2.27A 28.20% FAB 18-JUN-14 20140618 IMMUNE SYSTEM / HYDROLASE STRUCTURE OF A LYSOZYME ANTIBODY COMPLEX MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C,ALLERGEN GAL D IV; EC: 3.2.1.17; ? ? HOMO SAPIENS 14 TGRSSNIGAGYDVH 7 GNTNRPS 11 QSYDRSLSGSV 5 SNYMS 16 VIYSGGSTYYADSVKG 9 EGRGDSFVY crystal 1.95A 19.50% FAB 18-JUN-14 20140618 IMMUNE SYSTEM / HYDROLASE STRUCTURE OF A LYSOZYME ANTIBODY COMPLEX MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C,ALLERGEN GAL D IV; EC: 3.2.1.17; ? ? HOMO SAPIENS 14 TGRSSNIGAGYDVH 7 GNTNRPS 11 QSYDSSLSGSV 5 SNYMS 16 VIYSGGSTYYADSVKG 9 EGRGDSIDY crystal 1.92A 21.00% FAB 18-JUN-14 20140618 IMMUNE SYSTEM STRUCTURE OF A LYSOZYME ANTIBODY COMPLEX MOLECULE: LYSOZYME C; FRAGMENT: RESIDUES 19 - 147; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C,ALLERGEN GAL D IV; EC: 3.2.1.17; ? ? HOMO SAPIENS 14 TGRSSNIGAGYDVH 7 GNTNRPS 11 QSYDSSLRGSV 5 SNYMS 16 AIYSGGSTYYADSVKG 9 EGPGDSIVY crystal 2.15A 25.60% FAB 20-JUN-14 20140620 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN. MOLECULE: PEPTIDE1; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHRNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 0 17 AIDPYYGGTSYNQKFKG 4 GMEY crystal 1.89A 18.20% ? 24-JUN-14 20140624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN. MOLECULE: PEPTIDE2; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHRNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 5 GYNMN 17 AIDPYYGGTSYNQKFKG 4 GMEY crystal 1.60A 16.40% ? 24-JUN-14 20140624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN. MOLECULE: PEPTIDE2; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHRNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 4 YNMN 17 AIDPYYGGTSYNQKFKG 4 GMEY crystal 1.40A 18.90% ? 24-JUN-14 20140624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY AGAINST NEUROBLASTOMA ASSOCIATED ANTIGEN. ? ? ? MUS MUSCULUS 16 RSSQSLVHRNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 5 GYNMN 17 AIDPYYGGTSYNQKFKG 4 GMEY crystal 1.55A 16.80% ? 24-JUN-14 20140624 MEMBRANE PROTEIN LAP1 (AA356 - 583) , H.SAPIENS, BOUND TO VHH - BS1 MOLECULE: TORSIN - 1A - INTERACTING PROTEIN 1; FRAGMENT: UNP RESIDUES 356 - 583; SYNONYM: LAMIN - ASSOCIATED PROTEIN 1B,LAP1B; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 6 SSYAVG 19 FVATISRSGGSTHYADSVK 19 ATFTPDGSWYYTRGSSYDY crystal 1.60A 18.20% HC-dimer 27-JUN-14 20140627 IMMUNE SYSTEM HOMODIMERIC SINGLE DOMAIN ANTIBODY (SDAB) AGAINST STAPHYLOCOCCAL ENTEROTOXIN B (SEB) ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SRAVMG 19 AAISAAPGTAYYAFYADSV 19 AADLKMQVAAYMNQRSVDY crystal 2.13A 24.00% HC-dimer 09-JUL-14 20140709 IMMUNE SYSTEM HOMODIMERIC SINGLE DOMAIN ANTIBODY (SDAB) AGAINST STAPHYLOCOCCAL ENTEROTOXIN B (SEB) S74A VARIANT ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SRAVMG 19 AAISAAPGTAYYAFYADSV 19 AADLKMQVAAYMNQRSVDY crystal 2.50A 21.00% HC-dimer 11-JUL-14 20140711 IMMUNE SYSTEM PLASMODIUM FALCIPARUM RETICULOCYTE - BINDING PROTEIN HOMOLOGUE 5 (PFRH5) BOUND TO MONOCLONAL ANTIBODY 9AD4 MOLECULE: RETICULOCYTE BINDING PROTEIN 5; SYNONYM: RETICULOCYTE - BINDING PROTEIN HOMOLOGUE 5, PFRH5; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVEYYGTSLMQ 7 GASNVQS 9 QQSTKVPWT 5 DYGMA 17 FISNMAYSIYYADTVTG 13 AIFDYAGYWYFDV crystal 2.30A 22.30% ? 14-JUL-14 20140714 IMMUNE SYSTEM PLASMODIUM FALCIPARUM RETICULOCYTE - BINDING PROTEIN HOMOLOGUE 5 (PFRH5) BOUND TO MONOCLONAL ANTIBODY QA1 MOLECULE: RETICULOCYTE BINDING PROTEIN 5; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASQSVSTSSYTYFH 7 YASNLES 9 QHSWEIPYT 5 DFYMY 17 TISDGDSYIYYPDSVRG 13 DGNGKDGGDAMDY crystal 3.10A 23.80% ? 15-JUL-14 20140715 IMMUNE SYSTEM STRUCTURE OF A HUMAN VH ANTIBODY DOMAIN BINDING TO THE CLEFT OF HEN EGG LYSOZYME MOLECULE: LYSOZYME C; SYNONYM: 1,4 - BETA - N - ACETYLMURAMIDASE C,ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 AEDMG 17 SIYGPSGSTYYADSVKG 12 YTSPPQNHGFDY crystal 2.26A 19.20% HC-dimer 23-JUL-14 20140723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB IN COMPLEX WITH A HYDROCARBON - STAPLED HIV - 1 GP41 MPER PEPTIDE MOLECULE: SAH - MPER (662 - 683KKK) (B,Q); ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 4.20A 22.80% FAB 28-JUL-14 20140728 IMMUNE SYSTEM VACCINIA L1 / M12B9 - FAB COMPLEX MOLECULE: PROTEIN L1; SYNONYM: VIRION MEMBRANE PROTEIN M25; ENGINEERED: YES ? IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHDPWT 5 RFWMH 17 YINPSTGYTEYNQKFKD 10 SDQTNYLFPY crystal 3.10A 21.20% FAB 29-JUL-14 20140729 IMMUNE SYSTEM MECHANISMS OF NEUTRALIZATION OF A HUMAN ANTI - ALPHA TOXIN ANTIBODY MOLECULE: ALPHA - HEMOLYSIN; SYNONYM: ALPHA - HL,ALPHA - TOXIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASSLES 8 KQYADYWT 5 SHDMH 16 GIGTAGDTYYPDSVKG 14 DRYSPTGHYYGMDV crystal 2.56A 20.00% FAB 29-JUL-14 20140729 IMMUNE SYSTEM HOMODIMERIC SINGLE DOMAIN ANTIBODY (SDAB) AGAINST STAPHYLOCOCCAL ENTEROTOXIN B (SEB) CRYSTALLIZED FOR 5 MONTHS MOLECULE: SDAB A3; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SRAVMG 19 AAISAAPGTAYYAFYADSV 19 AADLKMQVAAYMNQRSVDY crystal 2.07A 23.30% HC-dimer 31-JUL-14 20140731 CELL INVASION CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM KNOWLESI IN COMPLEX WITH AN INVASION INHIBITORY ANTIBODY MOLECULE: APICAL MEROZOITE ANTIGEN 1; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: FRAGMENT 43 - 387 OF B3L5E1. N - TERMINAL RESIDUES GLU 41 AND PHE 42 ARE CLONING ARTIFACTS. C - TERMINAL RESIDUE GLY 388 IS A CLONING ARTIFACT, AND FOLLOWING RESIDUES LEU 389 TO HIS 410 CORRESPOND TO EXPRESSION TAGS.; ? ? RATTUS NORVEGICUS 11 QASQDIGNNLI 7 YATKLAN 9 LQYKQFPLT 5 NYYMA 17 TITTSGSRSYYPDSVKG 12 RGYGGYSEDFDY crystal 3.10A 19.30% ? 11-AUG-14 20140811 IMMUNE SYSTEM NEW DESIGN FOR MONOVALENT BISPECIFIC IGG THROUGH CYSTEINE ENGINEERING OF THE CH1 - CL INTERFACE ? ? IGG1 HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.20A 23.30% FAB 11-AUG-14 20140811 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A NEUTRALIZING HUMAN MONOCLONAL ANTIBODY WITH 1968 H3 HA MOLECULE: HEMAGGLUTININ HA1 CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASHRVGSTYIA 7 GASNRAT 9 QQFSVSPWT 5 TYGVS 17 WISAYTGITDYAQKFQG 17 DKVQGRVEVGSGGRHDY crystal 3.50A 21.50% ? 12-AUG-14 20140812 VIRAL PROTEIN CRYO - EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 IN COMPLEX WITH ANTIGEN - BINDING FRAGMENTS OF HUMAN ANTIBODY 2D22 MOLECULE: DENGUE VIRUS SEROTYPE 2 STRAIN STRAIN PVP94 07 - MEMBRANE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNVGSNYVY 7 RNNRRPS 11 ATWDDSLSGLV 5 NYAIS 17 GIIPIFGGANYAQKFQG 12 RPQSIFDWNFDL ElectronMicroscopy N/A N/A ? 30-MAR-15 20150330 VIRAL PROTEIN CRYO - EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA - C COMPLEXED WITH HUMAN ANTIBODY 2D22 FAB AT 37 DEGREE C. THE FAB MOLECULES WERE ADDED TO THE VIRUS BEFORE 37 DEGREE C INCUBATION. MOLECULE: DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA - C E PROTEIN ECTODOMAIN; EC: 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNVGSNYVY 7 RNNRRPS 11 ATWDDSLSGLV 5 NYAIS 17 GIIPIFGGANYAQKFQG 12 RPQSIFDWNFDL ElectronMicroscopy N/A N/A FAB 30-MAR-15 20150330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF QUININE - DEPENDENT FAB 314.1 ? ? ? MUS MUSCULUS 11 RASQDISNYLS 7 YTSKLHS 9 QQGNTLPPT 5 SYWMH 17 AIYPGNSDTSYNQKFKG 13 ERGLYYGSSSFDY crystal 2.00A 18.84% FAB 30-MAR-15 20150330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF QUININE - DEPENDENT FAB 314.1 WITH QUININE ? ? ? MUS MUSCULUS 11 RASQDISNYLS 7 YTSKLHS 9 QQGNTLPPT 5 SYWMH 17 AIYPGNSDTSYNQKFKG 13 ERGLYYGSSSFDY crystal 2.85A 27.47% FAB 30-MAR-15 20150330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF QUININE - DEPENDENT FAB 314.3 ? ? ? MUS MUSCULUS 11 RASQDISNYLT 7 YTSKLHS 9 QQGNSLPPT 5 SYWMH 17 TIYPGNSDSSYNQRFKG 13 ERGLYYGGRSFDY crystal 2.70A 22.23% FAB 30-MAR-15 20150330 IMMUNE SYSTEM CRYSTAL STRUCTURE OF QUININE - DEPENDENT FAB 314.3 WITH QUININE ? ? ? MUS MUSCULUS 11 RASQDISNYLT 7 YTSKLHS 9 QQGNSLPPT 5 SYWMH 17 TIYPGNSDSSYNQRFKG 13 ERGLYYGGRSFDY crystal 2.50A 20.65% FAB 30-MAR-15 20150330 IMMUNE SYSTEM INDUCED MONOMER OF THE MCG VARIABLE DOMAIN MOLECULE: IG LAMBDA CHAIN V - II REGION MGC; FRAGMENT: LIGHT - CHAIN VARIABLE DOMAIN, RESIDUES 1 - 110; SYNONYM: MCG - MONOMER; ENGINEERED: YES; MUTATION: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 11 SSYEGSDNAVE 0 N/A 0 N/A 0 N/A crystal 2.70A 24.56% LC-dimer 30-MAY-14 20140530 IMMUNE SYSTEM MCG - A DIMER OF LAMBDA VARIABLE DOMAINS MOLECULE: IG LAMBDA CHAIN V - II REGION MGC; FRAGMENT: LIGHT - CHAIN VARIABLE DOMAIN, RESIDUES 1 - 110; SYNONYM: MCG; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 0.95A 10.85% LC-dimer 30-MAY-14 20140530 IMMUNE SYSTEM COVALENT DIMER OF LAMBDA VARIABLE DOMAINS ? LAMBDA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; TISSUE: BLOOD; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: PET26B 14 TGTSSDVGGYNYVS 7 EVNKRPS 11 SSYEGSDNFVC 0 N/A 0 N/A 0 N/A crystal 1.60A 19.61% LC-dimer 30-MAY-14 20140530 IMMUNE SYSTEM ELECTRON CRYO - MICROSCOPY OF VENEZUELAN EQUINE ENCEPHALITIS VIRUS TC - 83 IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB 3B4C - 4 WITH NEUTRALIZING ANTIBODY FAB 3B4C - 4 ? ? HOMO SAPIENS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPFT 5 DYYIN 17 RIYPGYGNTKYNDKFKG 7 SLTFFDV ElectronMicroscopy N/A N/A FAB 04-JUN-14 20140604 VIRAL PROTEIN ELECTRON CRYO - MICROSCOPY OF VENEZUELAN EQUINE ENCEPHALITIS VIRUS TC - 83 IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB F5 WITH NEUTRALIZING ANTIBODY FAB F5 ? ? HOMO SAPIENS 13 SGSSSNIEGNTVN 7 GKDQRPS 11 AAWDDSLNGWV 5 DYYIN 17 RIYPGYGNTKYNDKFKG 7 SLTFFDV ElectronMicroscopy N/A N/A FAB 05-JUN-14 20140605 VIRAL PROTEIN CRYSTAL STRUCTURE OF DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN IN COMPLEX WITH THE FAB FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 B7 MOLECULE: ENVELOPE GLYCOPROTEIN E; FRAGMENT: SOLUBLE ECTODOMAIN, RESIDUES 281 - 671; SYNONYM: E PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGISSDVETYNLVS 7 EASKRPS 10 CSYAGGKSLV 5 SHWMH 17 RTNSDGSSTSYADSVKG 24 DGVRYYYDSTGYYPDNFFQYGLDV crystal 3.20A 21.40% FAB 18-JUL-14 20140718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SCFV FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 ? ? ? HOMO SAPIENS 14 CTGTSSNADTYNLV 7 YEGTKRP 11 CCSYATSRTLV 5 NHWMH 17 RINSDGSTRNYADFVKG 24 DGVRFYYDSTGYYPDSFFKYGMDV crystal 1.70A 16.17% FV 18-JUL-14 20140718 VIRAL PROTEIN CRYSTAL STRUCTURE OF DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN DIMER IN COMPLEX WITH THE SCFV FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C10 MOLECULE: ENVELOPE GLYCOPROTEIN E; FRAGMENT: SOLUBLE ECTODOMAIN, RESIDUES 281 - 671; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGGFNYVS 7 DVTSRPS 10 SSHTSRGTWV 5 SYAMH 17 WINAGNGNTKYSQKFQD 19 DKVDDYGDYWFPTLWYFDY crystal 3.20A 20.01% FV 18-JUL-14 20140718 IMMUNE SYSTEM - VIRAL PROTEIN COMPLEX CRYSTAL STRUCTURE OF DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN IN COMPLEX WITH THE FAB FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C8 MOLECULE: ENVELOPE GLYCOPROTEIN E; FRAGMENT: SOLUBLE ECTODOMAIN, RESIDUES 281 - 671; SYNONYM: E PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 CRASQSISTFL 7 YDASTRA 11 CQQRYNWPPYT 5 TYSMH 17 AITGEGDSAFYADSVKG 13 GYSNFYYYYTMDV crystal 3.00A 21.45% FAB 18-JUL-14 20140718 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN IN COMPLEX WITH THE FAB FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 MOLECULE: ENVELOPE GLYCOPROTEIN E; FRAGMENT: SOLUBLE ECTODOMAIN, RESIDUES 281 - 671; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSNADTYNLVS 7 EGTKRPS 10 CSYATSRTLV 5 NHWMH 17 RINSDGSTRNYADFVKG 24 DGVRFYYDSTGYYPDSFFKYGMDV crystal 3.85A 23.11% FAB 18-JUL-14 20140718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN C5A IN COMPLEX WITH MEDI7814 A NEUTRALISING ANTIBODY MOLECULE: COMPLEMENT C5; FRAGMENT: C5A; SYNONYM: C5A ANAPHYLATOXIN C5A, C3 AND PZP - LIKE ALPHA - 2 - MACROGLOBULIN DOMAIN - CONTAINING PROTEIN 4; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDIGGSKYVS 7 DVNRRPS 10 TSYHPTKTIL 5 SYAMS 17 AISGSGGSTYYADSVKG 15 DDDYEEWPWYYGMDV crystal 2.12A 17.59% FV 25-JUL-14 20140725 IMMUNE SYSTEM / METAL TRANSPORT POTASSIUM CHANNEL KCSA - FAB WITH TETRAHEXYLAMMONIUM MOLECULE: VOLTAGE - GATED POTASSIUM CHANNEL KCSA; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL, KCSA; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.40A 19.44% FAB 29-JUL-14 20140729 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - FPR FPRO0165 FAB FRAGMENT ? ? ? HOMO SAPIENS 16 RSSQPLLAMDGHNYLD 7 QSKWRAS 9 MQALQTPLT 5 NAWMN 19 RVKSKTDGGAADYAAPVKG 24 DQLGYDFWNGYYTDTLYYYFGMDV crystal 3.08A 24.46% FAB 04-AUG-14 20140804 TRANSFERASE THE COMPLEX STRUCTURE OF EXTRACELLULAR DOMAIN OF EGFR AND GC1118A MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: EXTRACELLULAR DOMAIN, UNP RESIDUES 25 - 645; SYNONYM: PROTO - ONCOGENE C - ERBB - 1, RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1, EPIDERMAL GROWTH FACTOR RECEPTOR 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSNQDLTHSNGNTYLE 7 KVSNRFS 9 MQGTHWPWT 5 DYDMS 17 GILGGSERSYYRDSVKG 13 HGSPGYTLYAWDY crystal 2.10A 20.43% ? 05-AUG-14 20140805 TOXIN / IMMUNE SYSTEM TERNARY COMPLEX AMONG TWO HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENTS AND CN2 TOXIN FROM SCORPION CENTRUROIDES NOXIUS. MOLECULE: BETA - MAMMAL TOXIN CN2; FRAGMENT: UNP RESIDUES 17 - 82; SYNONYM: TOXIN 2, TOXIN II.9.2.2; ? ? HOMO SAPIENS 11 CRASQSVRSYL 7 SDASNRA 10 CQQYRYSPRT 5 SYGMH 17 VISYGGGNKYYADSVKG 15 DARDCLLCADWHFDL crystal 3.10A 18.71% FV 25-SEP-14 20140925 IMMUNE SYSTEM ANTI - MARBURGVIRUS NUCLEOPROTEIN SINGLE DOMAIN ANTIBODY B COMPLEXED WITH NUCLEOPROTEIN C - TERMINAL DOMAIN MOLECULE: NUCLEOPROTEIN; FRAGMENT: C - TERMINAL DOMAIN RESIDUES 601 - 695; SYNONYM: NUCLEOCAPSID PROTEIN,PROTEIN N; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INTLG 16 RISSGGITRYADSVKG 10 RNWGGGLDVY crystal 3.20A 23.30% HC-dimer 17-AUG-17 20170817 IMMUNE SYSTEM ANTI - MARBURGVIRUS NUCLEOPROTEIN SINGLE DOMAIN ANTIBODY C ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SSAMG 16 SLTTTGTADYGDFVKG 10 DPYGMESLRY crystal 1.77A 16.70% HC-dimer 17-AUG-17 20170817 IMMUNE SYSTEM ANTI - MARBURGVIRUS NUCLEOPROTEIN SINGLE DOMAIN ANTIBODY C COMPLEXED WITH NUCLEOPROTEIN C - TERMINAL DOMAIN MOLECULE: NUCLEOPROTEIN; FRAGMENT: C - TERMINAL DOMAIN RESIDUES 632 - 695; SYNONYM: NUCLEOCAPSID PROTEIN,PROTEIN N; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SSAMG 16 SLTTTGTADYGDFVKG 10 DPYGMESLRY crystal 2.70A 22.50% HC-dimer 17-AUG-17 20170817 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FC AT 1.80 A ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; OTHER_DETAILS: THE PROTEIN IS COMMERCIALLY PURCHASED FROM ROCHE. 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.80A 20.10% FC 15-AUG-14 20140815 IMMUNE SYSTEM HIGH - RESOLUTION CRYSTAL STRUCTURE OF FC BOUND TO ITS HUMAN RECEPTOR FC - GAMMA - RI ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; OTHER_DETAILS: THE PROTEIN IS COMMERCIALLY PURCHASED FROM ROCHE.; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR1A, FCG1, FCGR1, IGFR1; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_TAXID: 7108; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.80A 17.50% FC 15-AUG-14 20140815 IMMUNE SYSTEM CYTOPLASMICALLY PRODUCED HOMODIMERIC SINGLE DOMAIN ANTIBODY (SDAB) C22A / C99V VARIANT AGAINST STAPHYLOCOCCAL ENTEROTOXIN B (SEB) ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SRAVMG 19 AAISAAPGTAYYAFYADSV 18 VAADLKMQVAAYMNQRSV crystal 2.00A 20.10% HC-dimer 20-AUG-14 20140820 CELL ADHESION CO - COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF6 MOLECULE: F18 FIMBRIAL ADHESIN AC; FRAGMENT: UNP RESIDUES 35 - 185; SYNONYM: FEDF; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RDSMG 16 CIDTSGIVNYADSVKG 17 GPFVYGRGCLGQAFYSY crystal 2.51A 20.00% HC-dimer 21-AUG-14 20140821 CELL ADHESION CO - COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF7 MOLECULE: F18 FIMBRIAL ADHESIN AC; FRAGMENT: UNP RESIDUES 35 - 185; SYNONYM: FEDF; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 KYCMG 17 CINSGGGTSYYADSVKG 16 SSNSVCPPGHVAWYND crystal 1.88A 18.80% HC-dimer 21-AUG-14 20140821 CELL ADHESION CO - COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF9 MOLECULE: F18 FIMBRIAL ADHESIN AC; FRAGMENT: UNP RESIDUES 35 - 185; SYNONYM: FEDF, LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SNCMA 17 SINTRGGITYYADSVKG 20 VREATYSDNRCSVRSYTYDY crystal 1.57A 19.60% HC-dimer 21-AUG-14 20140821 IMMUNE SYSTEM PERIPLASMICALLY PRODUCED MONOMERIC SINGLE DOMAIN ANTIBODY (SDAB) C22A / C99V VARIANT AGAINST STAPHYLOCOCCAL ENTEROTOXIN B (SEB) AT PH 7.0 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SRAVMG 19 AAISAAPGTAYYAFYADSV 18 VAADLKMQVAAYMNQRSV crystal 2.28A 19.00% HC-dimer 21-AUG-14 20140821 IMMUNE SYSTEM PERIPLASMICALLY PRODUCED MONOMERIC SINGLE DOMAIN ANTIBODY (SDAB) C22A / C99V VARIANT AGAINST STAPHYLOCOCCAL ENTEROTOXIN B (SEB) AT PH 8.0 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 FSRAVMG 19 VAAISAAPGTAYYAFYADS 17 VAADLKMQVAAYMNQRS crystal 2.25A 19.50% HC-dimer 22-AUG-14 20140822 IMMUNE SYSTEM FAB FRAGMENT OF MOUSE AZ130 MONOCLONAL ANTIBODY MOLECULE: AZ130 HEAVY CHAIN; ? ? MUS MUSCULUS 15 RASESVDSYGNSFLH 7 LASNLES 9 QQNNEAPFT 5 DTYIH 17 MINPANGNSNYDPKFQD 7 ITTDFDV crystal 2.00A 17.50% FAB 05-SEP-14 20140905 IMMUNE SYSTEM / VIRAL PROTEIN STRUCTURE OF THE CORE ECTODOMAIN OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN 2 MOLECULE: HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN 2; FRAGMENT: UNP RESIDUES 456 - 655; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLNSNNQKNYLA 7 FASTRES 9 QQHYSTPYT 5 DTYIH 17 RIDPANGHTQYDPKFQG 9 SDYSYALDS crystal 2.40A 20.40% FAB 09-SEP-14 20140909 STRUCTURAL PROTEIN CO - COMPLEX STRUCTURE OF THE F4 FIMBRIAL ADHESIN FAEG VARIANT AC WITH LLAMA SINGLE DOMAIN ANTIBODY V1 MOLECULE: K88 FIMBRIAL PROTEIN AC; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IDAMG 16 YISEGGILNYGDFVKG 13 SHWGTLLIKGIEH crystal 1.55A 17.00% HC-dimer 10-SEP-14 20140910 STRUCTURAL PROTEIN CO - COMPLEX STRUCTURE OF THE F4 FIMBRIAL ADHESIN FAEG VARIANT AC WITH LLAMA SINGLE DOMAIN ANTIBODY V2 MOLECULE: K88 FIMBRIAL PROTEIN AC; FRAGMENT: UNP RESIDUES 20 - 263; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INAMG 16 HITNTGVTEFADSVKG 13 TDWGTLLIKGIDH crystal 1.89A 19.00% HC-dimer 10-SEP-14 20140910 CELL ADHESION CO - COMPLEX STRUCTURE OF THE F4 FIMBRIAL ADHESIN FAEG VARIANT AD WITH LLAMA SINGLE DOMAIN ANTIBODY V3 MOLECULE: K88 FIMBRIAL PROTEIN AD; FRAGMENT: RESIDUES 40 - 285; SYNONYM: K88 ANTIGEN,K88 PILIN; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYAMG 17 AISWTGISTYYADIAKG 12 QKSLNVPAPWDY crystal 2.61A 20.60% HC-dimer 11-SEP-14 20140911 METAL TRANSPORT HUMAN TRAAK K+ CHANNEL IN A K+ BOUND CONDUCTIVE CONFORMATION MOLECULE: POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; SYNONYM: TWIK - RELATED ARACHIDONIC ACID - STIMULATED POTASSIUM CHANNEL PROTEIN,TRAAK,TWO PORE POTASSIUM CHANNEL KT4.1,TWO PORE K (+) CHANNEL KT4.1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSNSPPT 5 GYIMN 17 LINPNTGYTTYNQKFKG 7 GNYVFDY crystal 2.50A 20.10% FAB 15-SEP-14 20140915 METAL TRANSPORT HUMAN TRAAK K+ CHANNEL IN A K+ BOUND NONCONDUCTIVE CONFORMATION MOLECULE: POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; SYNONYM: TWIK - RELATED ARACHIDONIC ACID - STIMULATED POTASSIUM CHANNEL PROTEIN,TRAAK,TWO PORE POTASSIUM CHANNEL KT4.1,TWO PORE K (+) CHANNEL KT4.1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSNSPPT 5 GYIMN 17 LINPNTGYTTYNQKFKG 7 GNYVFDY crystal 2.50A 21.50% FAB 15-SEP-14 20140915 METAL TRANSPORT HUMAN TRAAK K+ CHANNEL IN A TL+ BOUND CONDUCTIVE CONFORMATION MOLECULE: POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; SYNONYM: TWIK - RELATED ARACHIDONIC ACID - STIMULATED POTASSIUM CHANNEL PROTEIN,TRAAK,TWO PORE POTASSIUM CHANNEL KT4.1,TWO PORE K (+) CHANNEL KT4.1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSNSPPT 5 GYIMN 17 LINPNTGYTTYNQKFKG 7 GNYVFDY crystal 3.00A 20.40% FAB 15-SEP-14 20140915 METAL TRANSPORT HUMAN TRAAK K+ CHANNEL IN A TL+ BOUND NONCONDUCTIVE CONFORMATION MOLECULE: POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; SYNONYM: TWIK - RELATED ARACHIDONIC ACID - STIMULATED POTASSIUM CHANNEL PROTEIN,TRAAK,TWO PORE POTASSIUM CHANNEL KT4.1,TWO PORE K (+) CHANNEL KT4.1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSNSPPT 5 GYIMN 17 LINPNTGYTTYNQKFKG 7 GNYVFDY crystal 3.01A 20.50% FAB 15-SEP-14 20140915 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH NANOBODY MOLECULE: DIVALENT METAL CATION TRANSPORTER MNTH; FRAGMENT: UNP RESIDUES 43 - 448; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IDTAN 16 TITRDGNANYADSVKG 13 AIRTTVRTSAQEY crystal 3.10A 25.10% HC-dimer 19-SEP-14 20140919 TRANSPORT PROTEIN STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE MOLECULE: DIVALENT METAL CATION TRANSPORTER MNTH; FRAGMENT: UNP RESIDUES 43 - 448; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IDTAN 16 TITRDGNANYADSVKG 13 AIRTTVRTSAQEY crystal 3.40A 25.30% HC-dimer 19-SEP-14 20140919 VIRAL PROTEIN STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY 3 / 11, P1 CRYSTAL FORM MOLECULE: EPITOPE PEPTIDE; FRAGMENT: UNP RESIDUES 51 - 62; ENGINEERED: YES ? ? RATTUS NORVEGICUS 16 RSSQSLLESDGNTYLN 7 SVSNLES 8 MQTTHAPT 5 DSYLA 17 SITNSGGRFYYRDSVKG 3 MDY crystal 2.22A 21.10% FAB 23-SEP-14 20140923 VIRAL PROTEIN STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY 3 / 11, P21 CRYSTAL FORM MOLECULE: EPITOPE PEPTIDE; FRAGMENT: UNP RESIDUES 51 - 62; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 16 RSSQSLLESDGNTYLN 7 SVSNLES 8 MQTTHAPT 5 DSYLA 17 SITNSGGRFYYRDSVKG 3 MDY crystal 2.62A 20.70% FAB 24-SEP-14 20140924 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC (WILD - TYPE) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F; EXPRESSION_SYSTEM_PLASMID: PEE6.4 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 22.90% FC 25-SEP-14 20140925 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION I253A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 22.40% FC 25-SEP-14 20140925 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION S254A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 24.70% FC 25-SEP-14 20140925 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION H310A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 23.40% FC 25-SEP-14 20140925 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION N434A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 22.90% FC 25-SEP-14 20140925 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION H435A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 23.30% FC 25-SEP-14 20140925 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION Y436A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 21.80% FC 25-SEP-14 20140925 IMMUNE SYSTEM STRUCTURAL MAPPING OF THE HUMAN IGG1 BINDING SITE FOR FCRN: HU3S193 FC MUTATION I253A / H310A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.65A 21.30% FC 25-SEP-14 20140925 IMMUNE SYSTEM CRYSTAL STRUCTURE OF APO CH65 FAB MOLECULE: CH65 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNDIGRKSVH 7 YDSDRPS 11 QVWDSSSDHVI 5 DYHIN 17 WIHPNSGDTNYAQKFQG 17 GGLEPRSVDYYYYGMDV crystal 1.70A 18.20% FAB 01-NOV-14 20141101 IMMUNE SYSTEM STRUCTURE OF ESK1 IN COMPLEX WITH HLA - A *0201 / WT1 MOLECULE: BETA - 2 - MICROGLOBULIN; FRAGMENT: UNP RESIDUES 21 - 119; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNTVN 7 SNNQRPS 11 AAWDDSLNGWV 5 NFWIS 17 RVDPGYSYSTYSPSFQG 12 VQYSGYYDWFDP crystal 3.05A 20.40% ? 03-NOV-14 20141103 TRANSFERASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FGFR2 D2 DOMAIN IN COMPLEX WITH FAB 2B.1.3 MOLECULE: FIBROBLAST GROWTH FACTOR RECEPTOR 2; FRAGMENT: UNP RESIDUES 153 - 251; SYNONYM: FGFR - 2,K - SAM,KGFR,KERATINOCYTE GROWTH FACTOR RECEPTOR; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVDTSLA 7 SASFLYS 9 QQSTGHPQT 5 STGIS 17 RTHLGDGSTNYADSVKG 18 TYGIYDLYVDYTEYVMDY crystal 2.36A 20.10% FAB 04-NOV-14 20141104 PROTEIN BINDING CRYSTAL STRUCTURE OF THE C DOMAIN OF STAPHYLOCOCCAL PROTEIN A IN COMPLEX WITH THE FC FRAGMENT OF HUMAN IGG AT 2.3 ANGSTROM RESOLUTION ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280; GENE: SPA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PAED4; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG3; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: ORIGAMI ROSETTA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.31A 21.10% FC 11-NOV-14 20141111 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RECOMBINANT 4E10 EXPRESSED IN ESCHERICHIA COLI WITH EPITOPE BOUND MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 662 - 674; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.10A 16.40% FAB 16-NOV-14 20141116 IMMUNE SYSTEM ENGINEERED FAB FRAGMENT SPECIFIC FOR EYMPME (EE) PEPTIDE ? ? ? HOMO SAPIENS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSLVPPT 7 TSGMGVN 16 HIYWDDDKRYNPSLKS 12 RGGSSHYYAMDY crystal 2.04A 16.70% FAB 21-NOV-14 20141121 IMMUNE SYSTEM STRUCTURE OF FCGAMMARI IN COMPLEX WITH FC REVEALS THE IMPORTANCE OF GLYCAN RECOGNITION FOR HIGH AFFINITY IGG BINDING ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR1A, FCG1, FCGR1, IGFR1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.49A 24.90% FC 03-DEC-14 20141203 IMMUNE SYSTEM RETROFITTING ANTIBODIES WITH STABILIZING MUTATIONS. HERCEPTIN SCFV MUTANT. MOLECULE: HUMAN VARIABLE HEAVY CHAIN OF HERCEPTIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SADFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 5 WAMDV crystal 2.25A 22.80% FV 04-DEC-14 20141204 IMMUNE SYSTEM RETROFITTING ANTIBODIES WITH STABILIZING MUTATIONS. HERCEPTIN SCFV MUTANT K30D / S52D. MOLECULE: HUMAN VARIABLE HEAVY CHAIN OF HERCEPTIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SADFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 6 WYAMDV crystal 2.49A 21.30% FV 04-DEC-14 20141204 IMMUNE SYSTEM RETROFITTING ANTIBODIES WITH STABILIZING MUTATIONS. HERCEPTIN VL MUTANT F53D. MOLECULE: HERCEPTIN VL DOMAIN WITH F53D MUTATION; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASDLYS 9 QQHYTTPPT 0 N/A 0 N/A 0 N/A crystal 1.80A 17.90% LC-dimer 04-DEC-14 20141204 VIRAL PROTEIN CRYSTAL STRUCTURE OF SAGA - 2006 GII.4 P DOMAIN IN COMPLEX WITH NANO - 85 MOLECULE: VP1; FRAGMENT: UNP RESIDUES 225 - 530; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 IYAMG 16 SISSGGGTNYADSVKG 12 EDYSAYAPPSGS crystal 2.00A 16.90% HC-dimer 09-DEC-14 20141209 VIRAL PROTEIN CRYSTAL STRUCTURE OF 2012 NSW GII.4 P DOMAIN IN COMPLEX WITH NANO - 85 MOLECULE: VP1; FRAGMENT: UNP RESIDUES 225 - 530; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IYAMG 15 ISSGGGTNYADSVKG 12 EDYSAYAPPSGS crystal 2.15A 19.80% HC-dimer 09-DEC-14 20141209 VIRAL PROTEIN CRYSTAL STRUCTURE OF NOROVIRUS GII.10 P DOMAIN IN COMPLEX WITH NANO - 85 MOLECULE: CAPSID PROTEIN; FRAGMENT: UNP RESIDUES 224 - 538; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 IYAMG 16 SISSGGGTNYADSVKG 12 EDYSAYAPPSGS crystal 2.11A 19.00% HC-dimer 09-DEC-14 20141209 VIRAL PROTEIN CRYSTAL STRUCTURE OF NOROVIRUS GII.10 P DOMAIN IN COMPLEX WITH NANO - 25 MOLECULE: CAPSID PROTEIN; FRAGMENT: VHH, UNP RESIDUES 224 - 538; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 FNHMA 16 VITREGSTDYADSVKG 5 GISNP crystal 1.70A 16.10% HC-dimer 09-DEC-14 20141209 IMMUNE SYSTEM STRUCTURE OF OMALIZUMAB FAB FRAGMENT CRYSTAL FORM 1 MOLECULE: EPIDIDYMIS LUMINAL PROTEIN 214; FRAGMENT: RESIDUES 20 - 241; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 15 RASQSVDYDGDSYMN 7 AASYLES 9 QQSHEDPYT 6 SGYSWN 16 SITYDGSTNYNPSVKG 12 GSHYFGHWHFAV crystal 1.90A 20.10% FAB 09-DEC-14 20141209 IMMUNE SYSTEM STRUCTURE OF OMALIZUMAB FAB FRAGMENT, CRYSTAL FORM 2 ? ? ? HOMO SAPIENS 15 RASQSVDYDGDSYMN 7 AASYLES 9 QQSHEDPYT 6 SGYSWN 16 SITYDGSTNYNPSVKG 12 GSHYFGHWHFAV crystal 3.00A 19.70% FAB 09-DEC-14 20141209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MURINE 7B4 FAB MONOCLONAL ANTIBODY AGAINST ADAMTS5 ? ? IGG1 MUS MUSCULUS 11 RTSENIYSYLA 7 NAKTLAE 9 QHKYGTPWT 5 DAWMD 19 EIRNKANNHARHYNESVKG 13 TYYYGSSYGYCDV crystal 2.60A 22.20% FAB 09-DEC-14 20141209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MURINE 12F4 FAB MONOCLONAL ANTIBODY AGAINST ADAMTS5 ? ? ? MUS MUSCULUS 11 KTSQSVGTTIV 7 SASNRHT 9 QQYTSYPFT 5 DAWMD 13 PEKGLEWVAEIRG 4 PFAY crystal 2.35A 21.80% FAB 10-DEC-14 20141210 IMMUNE SYSTEM IMMUNOGLOBULIN FC HETERODIMER VARIANT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F; EXPRESSION_SYSTEM_ORGAN: KIDNEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F; EXPRESSION_SYSTEM_ORGAN: KIDNEY 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 23.10% FC 11-DEC-14 20141211 IMMUNE SYSTEM IMMUNOGLOBULIN FC HETERODIMERS VARIANT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 25.10% FC 11-DEC-14 20141211 TRANSFERASE BETA - KETOACYL - ACYL CARRIER PROTEIN SYNTHASE III - 2 (FABH2) (C113A) FROM VIBRIO CHOLERAE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: VIBRIO CHOLERAE SEROTYPE O1; ORGANISM_TAXID: 243277; STRAIN: ATCC 39315 / EL TOR INABA N16961; GENE: FABH2, VC_A0751; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21-CODONPLUS(DE3)-RIL; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PMCSG7 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.61A 15.30% FAB 11-DEC-14 20141211 TRANSFERASE BETA - KETOACYL - ACP SYNTHASE III - 2 (FABH2) (C113A) FROM VIBRIO CHOLERAE SOAKED WITH OCTANOYL - COA: CONFORMATIONAL CHANGES WITHOUT CLEARLY BOUND SUBSTRATE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: VIBRIO CHOLERAE SEROTYPE O1 (STRAIN ATCC 39315 / EL TOR INABA N16961); ORGANISM_TAXID: 243277; STRAIN: ATCC 39315 / EL TOR INABA N16961; GENE: FABH2, VC_A0751; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21-CODONPLUS(DE3)-RIL; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PMCSG7 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 19.70% HC-dimer 11-DEC-14 20141211 IMMUNE SYSTEM CRYSTAL STRUCTURE OF POTENT NEUTRALIZING ANTIBODY M336 IN COMPLEX WITH MERS CO - V RBD MOLECULE: SPIKE GLYCOPROTEIN; FRAGMENT: RECEPTOR - BINDING DOMAIN (UNP RESIDUES 367 - 601); SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; ENGINEERED: YES; OTHER_DETAILS: MERS - COV RBD WITH HRV3C CLEAVAGE SITE AND HIS 6X TAG AT THE C - TERMINAL.; ? ? HOMO SAPIENS 11 RASQGIRNDLG 7 AASSLQS 9 QQLNSYPLT 5 SYAIS 17 GIIPIFGTASYAQKFQG 16 VGYCSSTSCNRGAFDI crystal 2.45A 20.10% ? 15-DEC-14 20141215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH ITS PEPTIDE EPITOPE ON HIV - 1 GP41: CRYSTALS CRYOPROTECTED WITH PHOSPHATIDIC ACID (08:0 PA) MOLECULE: FRAGMENT OF HIV GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 13 EGTTGKPIGAFAH crystal 1.47A 15.00% FAB 15-DEC-14 20141215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH ITS PEPTIDE EPITOPE ON HIV - 1 GP41: CRYSTALS CRYOPROTECTED WITH SPHINGOMYELIN (02:0 SM (D18:1 / 2:0) ) . MOLECULE: PEPTIDE FRAGMENT OF HIV GLYCOPROTEIN (GP41) INCLUDING THE REGION 671 - 683 OF THE MPER; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 14 EGTTLGKPIGAFAH crystal 1.76A 15.30% FAB 16-DEC-14 20141216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH PHOSPHATIDIC ACID (06:0 PA): 2.73 A RESOLUTION WITH PHOSPHATIDIC ACID (06:0 PA): 2.73 A RESOLUTION ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 16 EGTTGWLGKPIGAFAH crystal 2.73A 20.40% FAB 16-DEC-14 20141216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB CRYSTALIZED IN THE PRESENCE OF PHOSPHATIDYLETHANOLAMINE (06:0 PE) ? ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.94A 23.00% FAB 17-DEC-14 20141217 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH ITS PEPTIDE EPITOPE ON HIV - 1 GP41: CRYSTALS CRYOPROTECTED WITH SN - GLYCEROL 3 - PHOSPHATE MOLECULE: MODIFIED FRAGMENT OF HIV - 1 GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 1.63A 14.50% FAB 17-DEC-14 20141217 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH ITS PEPTIDE EPITOPE ON HIV - 1 GP41; CRYSTALS CRYOPROTECTED WITH RAC - GLYCEROL 1 - PHOSPHATE MOLECULE: MODIFIED FRAGMENT OF HIV - 1 GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 1.63A 13.90% FAB 17-DEC-14 20141217 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB CRYSTALIZED IN THE PRESENCE OF PHOSPHATIDYLCHOLINE (06:0 PC); I422 SPACE GROUP ? ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.81A 22.40% FAB 17-DEC-14 20141217 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB CRYSTALIZED IN THE PRESENCE OF PHOSPHATIDYLCHOLINE (06:0 PC); C2 SPACE GROUP ? ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.93A 19.50% FAB 17-DEC-14 20141217 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH ITS PEPTIDE EPITOPE ON HIV - 1 GP41; CRYSTALS CRYOPROTECTED WITH PHOSPHATIDYLCHOLINE (03:0 PC) MOLECULE: MODIFIED FRAGMENT OF HIV - 1 GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 14 EGTTLGKPIGAFAH crystal 1.43A 13.80% FAB 18-DEC-14 20141218 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH PHOSPHATIDIC ACID (06:0 PA); 2.9 A RESOLUTION WITH PHOSPHATIDIC ACID (06:0 PA); 2.9 A RESOLUTION ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.90A 19.50% FAB 18-DEC-14 20141218 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN 4E10 FAB IN COMPLEX WITH PHOSPHATIDYLGLYCEROL (06:0 PG) WITH PHOSPHATIDYLGLYCEROL (06:0 PG) ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 16 EGTTGWGGKPIGAFAH crystal 3.96A 24.60% FAB 18-DEC-14 20141218 CELL ADHESION CRYSTAL STRUCTURE OF HUMAN PAXILLIN LD2 MOTIF IN COMPLEX WITH FAB FRAGMENT MOLECULE: PAXILLIN LD2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSSSLIT 5 SYSSI 17 ASIYSYYGYTYYADSVK 10 RGYYGAAMDY crystal 2.50A 22.80% FAB 04-JAN-15 20150104 CELL ADHESION CRYSTAL STRUCTURE OF HUMAN PAXILLIN LD4 MOTIF IN COMPLEX WITH FAB FRAGMENT MOLECULE: PAXILLIN LD4; ENGINEERED: YES ? ? HOMO SAPIENS 8 RSVSSAVA 7 SASSLYS 11 QQFKRQKEPIT 5 SYSIH 17 YISSSSGYTYYADSVKG 8 TWYYGFDY crystal 2.00A 22.60% FAB 04-JAN-15 20150104 VIRAL PROTEIN / IMMUNE SYSTEM GHGL OF VARICELLA - ZOSTER VIRUS IN COMPLEX WITH HUMAN NEUTRALIZING ANTIBODIES. MOLECULE: ENVELOPE GLYCOPROTEIN L; SYNONYM: GL; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGLDNFLA 7 AASTLQR 9 QQLNSYSLT 5 GYHLH 17 WINPNSGETNYAQKFQD 12 GGMTMVRGVMMD crystal 3.16A 23.80% FAB 05-JAN-15 20150105 VIRAL PROTEIN / IMMUNE SYSTEM GHGL OF VARICELLA - ZOSTER VIRUS IN COMPLEX WITH HUMAN NEUTRALIZING ANTIBODIES MOLECULE: ENVELOPE GLYCOPROTEIN L; SYNONYM: GL; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISSWLA 7 AASSLQS 9 QQANNFPLT 5 TYAMH 17 VVSDGGGNRYYAASVKG 12 SRGNHYYYGMDV crystal 3.90A 24.70% FAB 06-JAN-15 20150106 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF FAB OF HIV - 1 GP120 V3 - SPECIFIC HUMAN MONOCLONAL ANTIBODY 2424 IN COMPLEX WITH JR - FL V3 PEPTIDE MOLECULE: HIV - 1 JR - FL GP120 V3 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 16 RASQSLLYSDGHNYLD 7 LGSTRAS 8 MQPLQSYT 5 EYYMT 16 VLYKDGSQFYAPSVKG 15 ENADYGSDYYFGMDV crystal 3.18A 22.80% FAB 14-JAN-15 20150114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB OF HIV - 1 GP120 V3 - SPECIFIC HUMAN MONOCLONAL ANTIBODY 2424 ? ? ? HOMO SAPIENS 16 RASQSLLYSDGHNYLD 7 LGSTRAS 8 MQPLQSYT 5 EYYMT 16 VLYKDGSQFYAPSVKG 15 ENADYGSDYYFGMDV crystal 2.68A 20.40% FAB 14-JAN-15 20150114 TRANSPORT PROTEIN / IMMUNE SYSTEM STRUCTURE OF THE YEAST COAT NUCLEOPORIN COMPLEX, SPACE GROUP C2 MOLECULE: NUCLEOPORIN NUP145; SYNONYM: NUCLEAR PORE PROTEIN NUP145; EC: 3.4.21. -; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 5 QQPIT 5 YSSIH 17 SIYPYYGSTSYADSVKG 6 TGALDY crystal 7.38A 33.20% ? 14-JAN-15 20150114 PROTEIN TRANSPORT STRUCTURE OF THE YEAST COAT NUCLEOPORIN COMPLEX, SPACE GROUP P212121 MOLECULE: NUCLEOPORIN NUP145; SYNONYM: NUCLEAR PORE PROTEIN NUP145; EC: 3.4.21. -; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 4 QQIT 5 SSSIH 17 SISSYYGYTSYADSVKG 4 YMDY crystal 7.60A 32.10% ? 14-JAN-15 20150114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC08 IN COMPLEX WITH HIV - 1 CLADE A STRAIN Q842.D12 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160,ENVELOPE GLYCOPROTEIN GP160, ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 195 - 297, 319 - 481; ENGINEERED: YES; ? ? HOMO SAPIENS 12 KTSQAITPRHLV 7 GTSERAS 5 QCLEA 5 EILIN 17 WMNPRGGGVNYARQFQG 23 GRSCCGGRRHCNGADCFNWDFQH crystal 1.78A 16.60% ? 15-JAN-15 20150115 VIRAL PROTEIN / IMMUNE SYSTEM ANTIBODY INFLUENZA H5 COMPLEX MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 74 - 285; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDTLGDKYVC 7 QDTKRPS 9 QAWDSSSFV 6 SSYWWS 16 EIYHSGNTNYNPSLKS 14 VALFDILTGGWFDP crystal 2.51A 21.50% FAB 15-JAN-15 20150115 VIRAL PROTEIN / IMMUNE SYSTEM ANTIBODY HEMAGGLUTININ COMPLEXES MOLECULE: INFLUENZA H5 HA HEAD DOMAIN VIETNAM RDT MUTATIONS; FRAGMENT: UNP RESIDUES 74 - 285; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDTLGDKYVC 7 QDTKRPS 9 QAWDSSSFV 6 SSYWWS 16 EIYHSGNTNYNPSLKS 14 VALFDILTGGWFDP crystal 2.00A 19.20% ? 15-JAN-15 20150115 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER IN COMPLEX WITH NISOXETINE MOLECULE: INTEGRAL MEMBRANE PROTEIN - DOPAMINE TRANSPORTER; ENGINEERED: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 2.98A 22.70% ? 16-JAN-15 20150116 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER IN COMPLEX WITH REBOXETINE MOLECULE: TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 3.00A 21.90% ? 16-JAN-15 20150116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC08C IN COMPLEX WITH HIV - 1 CLADE A STRAIN Q842.D12 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160,ENVELOPE GLYCOPROTEIN GP160, ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 195 - 297, 319 - 481; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RPSQAISKSHLA 7 GTYERAS 5 QCFEG 5 ESLIN 17 WMNPRGGGVNYAQRFQG 23 GKSCCNGRRYCNGADCFNWDFEY crystal 2.30A 18.40% ? 16-JAN-15 20150116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC06B IN COMPLEX WITH HIV - 1 CLADE A / E STRAIN 93TH057 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160,ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 10 KASQGGNSLS 7 DTSRRAS 5 QQFEF 5 EYSIH 19 WIKGMWGAVNYARQLQGRV 17 VRKGPSCPHCGDFHWQH crystal 3.39A 24.70% ? 16-JAN-15 20150116 MEMBRANE PROTEIN / TRANSPORT PROTEIN X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO NEUROTRANSMITTER DOPAMINE MOLECULE: DOPAMINE TRANSPORTER, ISOFORM B; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 2.89A 22.00% ? 16-JAN-15 20150116 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER IN COMPLEX WITH COCAINE MOLECULE: DOPAMINE TRANSPORTER; SYNONYM: DOPAMINE TRANSPORTER,ISOFORM A,GH22929P; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 2.80A 23.60% ? 16-JAN-15 20150116 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO COCAINE ANALOGUE - RTI55 MOLECULE: DOPAMINE TRANSPORTER, ISOFORM B; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 3.30A 24.70% ? 16-JAN-15 20150116 TRANPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO PSYCHOSTIMULANT METHAMPHETAMINE MOLECULE: TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 3.10A 23.70% ? 16-JAN-15 20150116 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO PSYCHOSTIMULANT D - AMPHETAMINE MOLECULE: TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 2.80A 21.20% ? 16-JAN-15 20150116 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO 3, 4DICHLOROPHENETHYLAMINE MOLECULE: TRANSPORTER; ENGINEERED: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 2.95A 23.10% ? 16-JAN-15 20150116 TRANPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER WITH SUBSITEB MUTATIONS (D121G / S426M) BOUND TO COCAINE MOLECULE: TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 3.05A 24.60% ? 16-JAN-15 20150116 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER WITH SUBSITEB MUTATIONS (D121G / S426M) BOUND TO RTI - 55 MOLECULE: DOPAMINE TRANSPORTER - PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 3.27A 24.40% ? 16-JAN-15 20150116 TRANSPORT PROTEIN / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER WITH SUBSITEB MUTATIONS (D121G / S426M) BOUND TO BETA - CFT OR WIN35428 MOLECULE: DOPAMINE TRANSPORTER; ENGINEERED: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 3.21A 25.20% ? 16-JAN-15 20150116 PROTEIN TRANSPORT / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER WITH SUBSITEB MUTATIONS (D121G / S426M) BOUND TO 3,4DICHLOROPHENETHYLAMINE MOLECULE: TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 2.90A 24.20% ? 17-JAN-15 20150117 PROTEIN TRANSPORT / INHIBITOR X - RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER WITH SUBSITEB MUTATIONS D121G / S426M AND EL2 DELETION OF 162 - 201 IN COMPLEX WITH SUBSTRATE ANALOGUE 3,4 DICHLOROPHEN ETHYLAMINE MOLECULE: DOPAMINE TRANSPORTER; SYNONYM: DOPAMINE TRANSPORTER,ISOFORM A,GH22929P; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 RASSSVGSSYLH 7 STSNLAS 9 QQFSGYPLT 5 SYAMS 17 EISSGGRYIYYSDTVTG 10 GEVRQRGFDY crystal 3.36A 23.20% ? 17-JAN-15 20150117 VIRAL PROTEIN / IMMUNE SYSTEM ANTIBODY HEMAGGLUTININ COMPLEXES MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 15 - 226; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDTLGDKYVC 7 QDTKRPS 9 QAWDSSSFV 6 SSYWWS 16 EIYHSGNTNYNPSLKS 14 VALFDILTGGWFDP crystal 2.74A 19.50% FAB 20-JAN-15 20150120 VIRAL PROTEIN / SIGNALLING PROTEIN STRUCTURE OF A NANOBODY - BOUND VIRAL GPCR BOUND TO HUMAN CHEMOKINE CX3CL1 MOLECULE: FRACTALKINE; FRAGMENT: UNP RESIDUES 25 - 101; SYNONYM: C - X3 - C MOTIF CHEMOKINE 1,CX3C MEMBRANE - ANCHORED CHEMOKINE, NEUROTACTIN,SMALL - INDUCIBLE CYTOKINE D1; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 IYAMG 16 RITFGGDTNYADSVKG 10 EETIVEEADY crystal 2.89A 20.40% HC-dimer 22-JAN-15 20150122 HYDROLASE / TRANSPORT PROTEIN STRUCTURE OF GET3 BOUND TO THE TRANSMEMBRANE DOMAIN OF PEP12 MOLECULE: ATPASE GET3; SYNONYM: ARSENICAL PUMP - DRIVING ATPASE, ARSENITE - STIMULATED ATPASE, GOLGI TO ER TRAFFIC PROTEIN 3, GUIDED ENTRY OF TAIL - ANCHORED PROTEINS 3; EC: 3.6. - . -; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS, SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 11 QQYPYYSSLIT 5 YYSIH 17 SISPYSSSTSYADSVKG 10 GRWYRRALDY crystal 2.05A 18.90% ? 23-JAN-15 20150123 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC 2 REGION 412 - 423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC33.1 MOLECULE: HCV E2 ANTIGEN; FRAGMENT: UNP RESIDUES 412 - 423; ENGINEERED: YES; ? ? HOMO SAPIENS 17 TISCSGGSFNIGNNYVS 7 DNDNRPS 11 GTWDSSLNVVV 6 TNFAVS 17 SAISSSDGSTYYSDSVK 19 RAVVSSDITYTYWSKYFDY crystal 2.00A 22.50% ? 27-JAN-15 20150127 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 DONOR 45 D45 - 01DG5 COREE GP120 WITH ANTIBODY 45 - VRC01.H01+07.O - 863513 / 45 - VRC01.L01+07.O - 110653 (VRC07_1995) MOLECULE: DONOR 45 01DG5 COREE GP120; ENGINEERED: YES ? ? HOMO SAPIENS 9 RTSQYGSLA 7 GGSSRAT 5 QQYEF 5 NCPIN 17 WMKPRGGAVNYPQKFQG 16 GKYCTASDYYNWDFEH crystal 1.90A 19.50% ? 27-JAN-15 20150127 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 93TH057 COREE GP120 WITH ANTIBODY 45 - VRC01.H01+07.O - 863513 / 45 - VRC01.L01+07.O - 110653 (VRC07_1995) MOLECULE: ENVELOPE GLYCOPROTEIN GP120 OF HIV - 1 CLADE A / E; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 GGSSRAT 5 QQYEF 5 NCPIN 17 WMKPRGGAVNYPQKFQG 16 GKYCTASDYYNWDFEH crystal 1.69A 18.30% ? 28-JAN-15 20150128 HYDROLASE / TRANSPORT PROTEIN STRUCTURE OF GET3 BOUND TO THE TRANSMEMBRANE DOMAIN OF NYV1 MOLECULE: ATPASE GET3; SYNONYM: ARSENICAL PUMP - DRIVING ATPASE,ARSENITE - STIMULATED ATPASE, GOLGI TO ER TRAFFIC PROTEIN 3,GUIDED ENTRY OF TAIL - ANCHORED PROTEINS 3; EC: 3.6. - . -; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS, SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 11 QQYPYYSSLIT 5 YYSIH 17 SISPYSSSTSYADSVKG 10 GRWYRRALDY crystal 2.35A 19.90% ? 28-JAN-15 20150128 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF LCAT (C31Y) IN COMPLEX WITH FAB1 MOLECULE: PHOSPHATIDYLCHOLINE - STEROL ACYLTRANSFERASE; FRAGMENT: UNP RESIDUES 25 - 440; SYNONYM: LECITHIN - CHOLESTEROL ACYLTRANSFERASE,PHOSPHOLIPID - CHOLESTEROL ACYLTRANSFERASE; EC: 2.3.1.43; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 SGDKLGNKFTS 7 QDTKRPS 10 QAWDSSTAWV 5 SYGMH 17 VIWYDGSNKFYEDSVKG 17 EGAAVRSFYYSYYGMDV crystal 2.65A 18.00% FAB 28-JAN-15 20150128 HYDROLASE / TRANSPORT PROTEIN STRUCTURE OF GET3 BOUND TO THE TRANSMEMBRANE DOMAIN OF SEC22 MOLECULE: ATPASE GET3; SYNONYM: ARSENICAL PUMP - DRIVING ATPASE,ARSENITE - STIMULATED ATPASE, GOLGI TO ER TRAFFIC PROTEIN 3,GUIDED ENTRY OF TAIL - ANCHORED PROTEINS 3; EC: 3.6. - . -; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS, SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 11 QQYPYYSSLIT 5 YYSIH 17 SISPYSSSTSYADSVKG 10 GRWYRRALDY crystal 2.75A 19.80% ? 29-JAN-15 20150129 HYDROLASE / IMMUNE SYSTEM LOW RESOLUTION STRUCTURE OF LCAT IN COMPLEX WITH FAB1 MOLECULE: PHOSPHATIDYLCHOLINE - STEROL ACYLTRANSFERASE; SYNONYM: LECITHIN - CHOLESTEROL ACYLTRANSFERASE,PHOSPHOLIPID - CHOLESTEROL ACYLTRANSFERASE; EC: 2.3.1.43; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDKLGNKFTS 7 QDTKRPS 10 QAWDSSTAWV 5 SYGMH 17 VIWYDGSNKFYEDSVKG 17 EGAAVRSFYYSYYGMDV crystal 3.60A 20.00% FAB 29-JAN-15 20150129 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MID - REGION AMYLOID BETA CAPTURE BY SOLANEZUMAB MOLECULE: AMYLOID - BETA FRAGMENT; FRAGMENT: UNP RESIDUES 683 - 699; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSLIYSDGNAYLH 7 KVSNRFS 9 SQSTHVPWT 5 RYSMS 17 QINSVGSSTYYPDTVKG 3 GDY crystal 2.41A 25.10% FAB 30-JAN-15 20150130 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN FACTOR VIII C2 DOMAIN IN COMPLEX WITH MURINE 3E6 INHIBITORY ANTIBODY MOLECULE: COAGULATION FACTOR VIII; SYNONYM: ANTIHEMOPHILIC FACTOR,AHF,PROCOAGULANT COMPONENT; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSTVSYMY 7 DTSNLAS 9 QHWSSYPLT 5 DYSLH 17 WINTETGDPAYADDFKG 7 EDDGLAS crystal 2.61A 20.20% FAB 05-FEB-15 20150205 PROTEIN BINDING / IMMUNE SYSTEM DIABODY 305 COMPLEX WITH EPOR MOLECULE: ERYTHROPOIETIN RECEPTOR; SYNONYM: EPO - R; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 14 TGTSSDVGGYIYVS 7 DVSRRPS 10 NSYTTLSTWL 6 SSYWMS 17 ANIKPDGSEKYYVDSVK 10 RVSRGGSYSD crystal 2.60A 18.90% ? 12-FEB-15 20150212 PROTEIN BINDING / IMMUNE SYSTEM DIABODY 305 COMPLEX WITH EPOR MOLECULE: ERYTHROPOIETIN RECEPTOR; SYNONYM: EPO - R; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSSSNIGNNAVS 7 YDNLLPS 11 AAWDDSLNDWV 5 SYAMS 17 AISGSGGSTYYADSVKG 15 DRVAVAGKGSYYFDS crystal 3.15A 20.40% ? 12-FEB-15 20150212 PROTEIN BINDING / IMMUNE SYSTEM DIABODY 330 COMPLEX WITH EPOR MOLECULE: ERYTHROPOIETIN RECEPTOR; SYNONYM: EPO - R; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 14 TGTSSDVGAYNYVS 7 EVARRPS 11 SSYAGSNNFAV 4 YWMT 16 NIPDGSEKYYVESVKG 9 VSRGGSFSD crystal 2.85A 22.10% ? 12-FEB-15 20150212 TRANSFERASE CRYSTAL STRUCTURE OF CYCLIN - G ASSOCIATED KINASE (GAK) COMPLEXED WITH SELECTIVE 12I INHIBITOR ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: GAK; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_VARIANT: R3 PRARE2; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PNIC28-BSA4; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844 0 0 0 0 0 0 crystal 2.10A 19.40% Nanobody 16-FEB-15 20150216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A COMPUTATIONALLY OPTIMIZED PG9 MUTANT MOLECULE: PG9_N100FY LIGHT CHAIN; ENGINEERED: YES ? ? HOMO SAPIENS 14 NGTSNDVGGYESVS 7 DVSKRPS 10 KSLTSTRRRV 5 RQGMH 19 FIKYDGSEKYHADSVWGRL 26 EAGGPDYRNGYYDFYDGYYNYHYMDV crystal 2.30A 20.60% FAB 17-FEB-15 20150217 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE STABILIZED INNER DOMAIN OF CLADE A / E HIV - 1 GP120 IN COMPLEX WITH THE ADCC MEDIATING ANTI - HIV - 1 ANTIBODY A32 MOLECULE: STABILIZED INNER DOMAIN OF CLADE A / E GP120; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNNRPS 10 SSYTDIHNFV 6 GAHYWS 16 YIHYSGNTYYNPSLKS 13 GTRLRTLRNAFDI crystal 3.10A 23.50% FAB 18-FEB-15 20150218 TRANSPORT PROTEIN / IMMUNE SYSTEM RAT GLUT5 WITH FV IN THE OUTWARD - OPEN FORM MOLECULE: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 5; SYNONYM: FRUCTOSE TRANSPORTER,GLUCOSE TRANSPORTER TYPE 5,SMALL INTESTINE,GLUT - 5; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 16 SCRSSQSIVHSNGNTY 7 IYKVSNR 11 YCFQGSHVPYT 6 SSFGMH 17 AHISSGSRTIDYADTVK 11 RGNGYYDALDY crystal 3.27A 24.40% FV 19-FEB-15 20150219 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE STABILIZED INNER DOMAIN OF CLADE A / E HIV - 1 GP120 FROM E. COLI IN COMPLEX WITH THE ANTIBODY A32. MOLECULE: THE STABILIZED INNER DOMAIN OF CLADE A / E HIV - 1 GP120 FROM E. COLI; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNNRPS 10 SSYTDIHNFV 6 GAHYWS 16 YIHYSGNTYYNPSLKS 13 GTRLRTLRNAFDI crystal 3.02A 23.00% FAB 19-FEB-15 20150219 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROAD AND POTENTLY NEUTRALIZING VRC01 - CLASS ANTIBODY Z258 - VRC27.01, ISOLATED FROM HUMAN DONOR Z258, IN COMPLEX WITH HIV - 1 GP120 FROM CLADE A STRAIN Q23.17 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 191 - 293, 315 - 482; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGIGSDLH 7 HASAREE 5 QVIES 5 AYILH 17 WIKPKFGAVNYAHSFQG 13 DRLYDGSSWRLDP crystal 3.45A 22.50% ? 22-FEB-15 20150222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 44 - VRC13.01 IN COMPLEX WITH HIV - 1 CLADE AE STRAIN 93TH057 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160,ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.31A 22.50% ? 22-FEB-15 20150222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY C38 - VRC16.01 IN COMPLEX WITH HIV - 1 CLADE AE STRAIN 93TH057 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160,ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486,UNP RESIDUES 43 - 122, 201 - 303, 325 - 486,UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDIANYLN 7 GATNLHH 9 QQSFQTVGS 5 NYAMG 17 VTSAHGGSAYFGEFVKG 20 VTFYHEGSGYYYRAGNYFDS crystal 2.05A 16.80% ? 22-FEB-15 20150222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY C38 - VRC18.02 IN COMPLEX WITH HIV - 1 CLADE AE STRAIN 93TH057GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160,ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RTSQGILSNQLA 7 GGSNRAP 5 QILEF 5 DHFIH 19 WINPRGGGVNYSRSFQGKL 10 GFAGYEWSFI crystal 1.80A 17.60% ? 22-FEB-15 20150222 IMMUNE SYSTEM STRUCTURE OF THE ANTIBODY 7B2 THAT CAPTURES HIV - 1 VIRIONS MOLECULE: HIV GP41 PEPTIDE GP41 (596 - 606); FRAGMENT: HIV GP41 PEPTIDE GP41 (596 - 606); ENGINEERED: YES; KAPPA ? HOMO SAPIENS 8 KSSQHSIA 7 WASMRLS 9 HQYSSHPPT 5 EYYMT 17 YISKNGEYSKYSPSSNG 17 ADGLTYFSELLQYIFDL crystal 2.70A 19.10% ? 23-FEB-15 20150223 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF NEUTRALIZING ANTIBODY HJ16 IN COMPLEX WITH HIV - 1 GP120 MOLECULE: HT593.1 GP120; ENGINEERED: YES; OTHER_DETAILS: HIV - 1 CLADE B GP120 CORE; ? ? HOMO SAPIENS 17 KSSHSLLYAPYDKDALV 7 WASSRRS 10 CQQTRWTPPT 5 RNGFE 16 TVTFESKTHVTASARG 19 DQTIFHKNGAVDFFSYFDL crystal 2.72A 19.00% ? 23-FEB-15 20150223 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VH1 - 46 GERMLINE - DERIVED CD4 - BINDING SITE - DIRECTED ANTIBODY 1B2530 IN COMPLEX WITH HIV - 1 CLADE A / E 93TH057 GP120 MOLECULE: ENVELOPE GLYCOPROTEIN GP160,ENVELOPE GLYCOPROTEIN GP160, ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 43 - 122, 201 - 303, 325 - 486,UNP RESIDUES 43 - 122, 201 - 303, 325 - 486,UNP RESIDUES 43 - 122, 201 - 303, 325 - 486; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGGPSNVGGNYVY 7 RDDQRPS 11 ATYDSDGSIRL 5 KYIIH 19 MIDPYRGRPWSAHKFQGRL 16 AEAASDSHSRPIMFDH crystal 3.39A 27.50% ? 25-FEB-15 20150225 METAL BINDING PROTEIN CDPK1, FROM TOXOPLASMA GONDII, BOUND TO INHIBITORY VHH - 1B7 MOLECULE: CALMODULIN - DOMAIN PROTEIN KINASE 1; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 DHSAV 17 LCINANGVSLDYADSIK 15 ATREFCSAYVFLYEH crystal 2.94A 22.70% HC-dimer 26-FEB-15 20150226 IMMUNE SYSTEM REVERSAL AGENT FOR DABIGATRAN ? ? ? HOMO SAPIENS 16 RSSQSIVHSDGNIYLE 7 KVSYRFS 9 FQASHVPYT 5 DYYMH 17 ETNPRNGGTTYNEKFKG 10 GTSGYDYFDY crystal 1.76A 17.90% FAB 26-FEB-15 20150226 IMMUNE SYSTEM REVERSAL AGENT FOR DABIGATRAN ? ? ? HOMO SAPIENS 16 RSSQSIVHSDGNIYLE 7 KVSYRFS 9 FQASHVPYT 5 DYYMH 17 ETNPRNGGTTYNEKFKG 10 GTSGYDYFDY crystal 1.90A 18.30% FAB 27-FEB-15 20150227 IMMUNE SYSTEM REVERSAL AGENT FOR DABIGATRAN ? ? ? HOMO SAPIENS 16 RSSQSIVHSDGNIYLE 7 KVSYRFS 9 FQASHVPYT 5 DYYMH 17 ETNPRNGGTTYNEKFKG 10 GTSGYDYFDY crystal 2.21A 17.70% FAB 27-FEB-15 20150227 IMMUNE SYSTEM REVERSAL AGENT FOR DABIGATRAN ? ? ? HOMO SAPIENS 16 RSSQSIVHSDGNIYLE 7 KVSYRFS 9 FQASHVPYT 5 DYYMH 17 ETNPRNGGTTYNEKFKG 10 GTSGYDYFDY crystal 2.09A 18.30% FAB 27-FEB-15 20150227 IMMUNE SYSTEM REVERSAL AGENT FOR DABIGATRAN ? ? ? HOMO SAPIENS 16 RSSQSIVHSDGNIYLE 7 KVSYRFS 9 FQASHVPYT 5 DYYMH 17 ETNPRNGGTTYNEKFKG 10 GTSGYDYFDY crystal 2.16A 17.20% FAB 27-FEB-15 20150227 IMMUNE SYSTEM REVERSAL AGENT FOR DABIGATRAN ? ? ? HOMO SAPIENS 16 RSSQSIVHSDGNIYLE 7 KVSYRFS 9 FQASHVPYT 5 DYYMH 17 ETNPRNGGTTYNEKFKG 10 GTSGWDYFDY crystal 1.82A 18.20% FAB 27-FEB-15 20150227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 309M3 - B FAB IN COMPLEX WITH H3K9ME3 PEPTIDE MOLECULE: H3K9ME3 PEPTIDE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGTNIGDISVH 7 DDSDRPS 11 QVWDDSINAYV 5 DYWMS 17 DINPDGITRYYIDAVKG 12 EFHSGLGWHFDL crystal 2.53A 21.30% FAB 27-FEB-15 20150227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 309M3 - B IN COMPLEX WITH TRIMETHYLATED LYS WITH TRIMETHYLATED LYS ? ? HOMO SAPIENS 11 GGTNIGDISVH 7 DDSDRPS 11 QVWDDSINAYV 5 DYWMS 17 DINPDGITRYYIDAVKG 12 EFHSGLGWHFDL crystal 1.90A 20.80% FAB 27-FEB-15 20150227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 304M3 - B FAB IN COMPLEX WITH H3K4ME3 PEPTIDE MOLECULE: H3K4ME3 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 GGTNIGDISVH 7 DDSDRPS 11 QVWDDSINAYV 5 DYWMS 17 DIHQDGQVRYYLDAVKG 12 NFVRGFGWHFDL crystal 2.30A 18.40% FAB 27-FEB-15 20150227 VIRAL PROTEIN / IMMUNE SYSTEM HUMAN ANTIBODY H2526 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ H1 SOLOMON ISLANDS / 03 / 2006 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNVGTNAVD 7 YNNQRPS 11 ATWDNSLNDRV 7 VGTNAVD 13 LLIYYNNQRPSGV 26 WDNSLNDRVFGGGTKLTVLQVQLVQS crystal 2.72A 23.10% scFv 03-MAR-15 20150303 VIRAL PROTEIN / IMMUNE SYSTEM HUMAN ANTIBODY 641 I - 9 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ H1 SOLOMON ISLANDS / 03 / 2006 MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 65 - 280; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSIPLT 5 SYYWS 16 YIYYSGSTDYNPSLKS 17 RRSDFETVDFIYHYMDV crystal 2.80A 22.20% ? 03-MAR-15 20150303 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTI - HUMAN PODOPLANIN ANTIBODY NZ - 1 ? ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVN 7 RDDKRPD 10 FCHSYSSGIV 5 NYGMA 17 SISAGGDKTYYGDSVKG 8 TSRVYFDY crystal 1.58A 17.00% FAB 11-MAR-15 20150311 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTI - HUMAN PODOPLANIN ANTIBODY NZ - 1 WITH BOUND PA PEPTIDE MOLECULE: PA14 PEPTIDE; ENGINEERED: YES ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVN 7 RDDKRPD 10 FCHSYSSGIV 5 NYGMA 17 SISAGGDKTYYGDSVKG 8 TSRVYFDY crystal 1.56A 18.10% FAB 11-MAR-15 20150311 IMMUNE SYSTEM STRUCTURAL INSIGHTS INTO THE NEUTRALIZATION PROPERTIES OF A HUMAN ANTI - INTERFERON MONOCLONAL ANTIBODY MOLECULE: INTERFERON ALPHA - 2; SYNONYM: IFN - ALPHA - 2,INTERFERON ALPHA - A,LEIF A; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVSSTYLA 7 GASSRAT 9 QQYGSSPRT 5 SYSIS 17 WISVYNGNTNYAQKFQG 7 DPIAAGY crystal 3.00A 20.90% ? 12-MAR-15 20150312 CYTOKINE / IMMUNE SYSTEM MOUSE IL - 2 BOUND TO JES6 - 1 SCFV FRAGMENT MOLECULE: INTERLEUKIN - 2; SYNONYM: IL - 2, T - CELL GROWTH FACTOR, TCGF; ENGINEERED: YES ? ? MUS MUSCULUS 17 NCKSSQSLLSSGNQKNY 7 IYYASTG 11 YCLQHYISPPT 5 DYLIH 17 WIDPEDGETRYAQKFQS 12 SLDSTYIYPFAY crystal 2.83A 17.10% FV 13-MAR-15 20150313 IMMUNE SYSTEM FAB FRAGMENT OF 5G6 IN COMPLEX WITH EPITOPE PEPTIDE MOLECULE: ACE - LYS - LEU - ARG - GLY - VAL - LEU - GLN - GLY - HIS - LEU; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIYNYLA 7 NAKTLAD 9 QHFWDTPWT 7 TSNMGVV 16 HILWNDGKFYNPALKS 12 LFTTTTSGYFDV crystal 2.38A 21.40% FAB 14-MAR-15 20150314 CYTOKINE / IMMUNE SYSTEM MOUSE IL - 2 BOUND TO S4B6 FAB FRAGMENT MOLECULE: INTERLEUKIN - 2; SYNONYM: IL - 2, T - CELL GROWTH FACTOR, TCGF; ENGINEERED: YES ? ? MUS MUSCULUS 11 CQASQDIGNYL 7 HSATSLA 10 CLQHYSTPYT 6 AYYLHF 17 RIDPEDDSTKYAENFKN 14 VTFYYSRELRWFAY crystal 2.19A 20.50% FAB 18-MAR-15 20150318 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF 830A IN COMPLEX WITH V1V2 MOLECULE: SCAFFOLD HIV - 1 GP120 V1V2 REGION DERIVED FROM STRAIN ZM109; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQIINTNLA 7 AASARAT 10 QQYKHWPPYT 5 RYYWS 16 QIDHTGSTTYNPSLKG 18 APSGYPGVSLYQYYGLDV crystal 3.00A 22.30% ? 20-MAR-15 20150320 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOVINE PRION PROTEIN COMPLEXED WITH POM1 FAB MOLECULE: MAJOR PRION PROTEIN; SYNONYM: PRP,MAJOR SCRAPIE - ASSOCIATED FIBRIL PROTEIN 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 2.19A 21.80% FAB 22-MAR-15 20150322 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DEER PRION PROTEIN COMPLEXED WITH POM1 FAB MOLECULE: MAJOR PRION PROTEIN; SYNONYM: PRP; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 2.70A 24.50% FAB 23-MAR-15 20150323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ELK PRION PROTEIN COMPLEXED WITH POM1 FAB MOLECULE: MAJOR PRION PROTEIN; SYNONYM: PRP; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 2.81A 30.30% FAB 23-MAR-15 20150323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SYRIAN HAMSTER PRION PROTEIN COMPLEXED WITH POM1 FAB MOLECULE: MAJOR PRION PROTEIN; SYNONYM: PRP,PRP27 - 30,PRP33 - 35C; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQNIGTSIH 7 YASESIS 9 QQSNTWPYT 5 DYWMH 17 SIDPSDSYTSHNEKFKG 10 SGYGYYAMEY crystal 2.60A 26.50% FAB 23-MAR-15 20150323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANION EXCHANGER DOMAIN OF HUMAN ERYTHROCYTE BAND 3 MOLECULE: BAND 3 ANION TRANSPORT PROTEIN; SYNONYM: ANION EXCHANGE PROTEIN 1,ANION EXCHANGER 1,SOLUTE CARRIER FAMILY 4 MEMBER 1; OTHER_DETAILS: OUTWARD FACING STRUCTURE OF HUMAN ANION EXCHANGER 1 (BAND 3) IN CO - CRYSTALLISED WITH FAB ANTIBODY FRAGMENTS.; ? ? MUS MUSCULUS 15 RASQSVSTSSYSYMN 7 YASNLES 9 QHSWEIPWT 7 TSGIGVG 16 HIWWSASKYYNTALKS 13 AYYGNYGGYYFDY crystal 3.50A 27.50% FAB 25-MAR-15 20150325 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - OFLOXACIN ANTIBODY AND EXPLORATION ITS RECEPTOR BINDING SITE ? ? ? MUS MUSCULUS 10 SASSSVSEMH 0 9 QQGSENTET 5 SYAME 17 YISTGGGSTYYADSVKG 13 HNYYGGRIYSMDY crystal 3.20A 27.80% FAB 26-MAR-15 20150326 IMMUNE SYSTEM STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 434 - 446 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC26AM MOLECULE: HCV E2 ANTIGEN (RESIDUES 432 - 446); ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDKLGDKYVS 7 QDSKRPS 9 QAWDSSALV 5 NYVIT 17 GFIPDFRTAMYAQGFQG 10 GPLSRGYYDY crystal 2.00A 23.00% ? 26-MAR-15 20150326 CYTOKINE / IMMUNE SYSTEM RONTALIZUMAB FAB BOUND TO INTERFERON - A2 MOLECULE: INTERFERON ALPHA - 2; SYNONYM: IFN - ALPHA - 2,INTERFERON ALPHA - A,LEIF A; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASQSVSTSSYSYMH 7 YASNLES 9 QHSWGIPRT 5 EYIIH 17 SINPDYDITNYNQRFKG 8 WISDFFDY crystal 3.00A 22.30% FAB 02-APR-15 20150402 MEMBRANE PROTEIN / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 IN COMPLEX WITH AGDV PEPTIDE MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 29 - 497; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA,GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.60A 23.00% ? 07-APR-15 20150407 MEMBRANE PROTEIN / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 IN COMPLEX WITH AGDV PEPTIDE MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 29 - 497; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA,GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.85A 22.40% FAB 07-APR-15 20150407 MEMBRANE PROTEIN / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 IN COMPLEX WITH AGDV - NH2 PEPTIDE MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 29 - 497; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA,GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.70A 18.80% ? 07-APR-15 20150407 IMMUNE SYSTEM / DNA FAB STRUCTURE OF ANTIBODY S1 - 15 IN COMPLEX WITH SSDNA DNA, 5' - P5 (DT) P - 3' MOLECULE: 5' - D (P *TP *TP *TP *TP *T) - 3'; ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLRS 9 QQGNTLPWT 5 TYAMN 19 RIRSKSNNYATYYADSVKD 16 HRGAPLYYGNGAWFAY crystal 1.75A 20.90% FAB 08-APR-15 20150408 IMMUNE SYSTEM / DNA FAB STRUCTURE OF ANTIBODY S1 - 15 IN COMPLEX WITH SSDNA DNA, 5' - 5 (DT) - P - 3' WITH SSDNA DNA, 5' - 5 (DT) - P - 3' ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLRS 9 QQGNTLPWT 5 TYAMN 19 RIRSKSNNYATYYADSVKD 16 HRGAPLYYGNGAWFAY crystal 1.79A 20.50% FAB 09-APR-15 20150409 HYDROLASE / IMMUNE SYSTEM RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH2) (F5) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: RICINUS COMMUNIS; ORGANISM_COMMON: CASTOR BEAN; ORGANISM_TAXID: 3988; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.50A 17.90% Nanobody 10-APR-15 20150410 IMMUNE SYSTEM STRUCTURE OF A TRANSGLUTAMINASE 2 - SPECIFIC AUTOANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASSLES 11 QHYNSYSPGYT 5 SYWIG 17 IIYPGDSDTRYSPSFQG 12 PHYYDSLDAFDI crystal 2.40A 20.40% FAB 16-APR-15 20150416 SIGNALING PROTEIN / IMMUNE SYSTEM DUAL - ACTING FAB 5A12 IN COMPLEX WITH VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; FRAGMENT: UNP RESIDUES 217 - 315; SYNONYM: VEGF - A,VASCULAR PERMEABILITY FACTOR,VPF; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQFLSSFGVA 7 GASSLYS 9 QQGLLSPLT 5 DYWIH 17 GITPAGGYTYYADSVKG 11 FVFFLPYAMDY crystal 2.75A 19.90% FAB 21-APR-15 20150421 SIGNALING PROTEIN / IMMUNE SYSTEM DUAL - SPECIFICITY FAB 5A12 IN COMPLEX WITH ANGIOPOIETIN 2 MOLECULE: ANGIOPOIETIN - 2; FRAGMENT: RECEPTOR BINDING DOMAIN, UNP RESIDUES 225 - 444; SYNONYM: ANG - 2; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQFLSSFGVA 7 GASSLYS 9 QQGLLSPLT 5 DYWIH 17 GITPAGGYTYYADSVKG 11 FVFFLPYAMDY crystal 2.27A 17.90% FAB 21-APR-15 20150421 IMMUNE SYSTEM J22.9 - XI: CHIMERIC MOUSE / HUMAN ANTIBODY AGAINST HUMAN BCMA (CD269) MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17; FRAGMENT: EXTRACELLULAR (N - TERMINAL) DOMAIN, UNP RESIDUES 1 - 54; SYNONYM: B - CELL MATURATION PROTEIN, BCMA, CD269; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQSVDSNVA 7 SASLRFS 9 QQYNNYPLT 5 RYWMS 17 EINPDSSTINYAPSLKD 11 LYYDYGDAMDY crystal 1.90A 17.80% FAB 21-APR-15 20150421 PROTEIN BINDING CRYSTAL STRUCTURE OF A NANOBODY RAISED AGAINST KDM5B MOLECULE: NB17; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IRTMG 16 IISSGGSTDYADSVKG 9 RVGITMLAH crystal 1.85A 18.80% HC-dimer 22-APR-15 20150422 PROTEIN BINDING FC FRAGMENT OF HUMAN IGG IN COMPLEX WITH THE C DOMAIN OF STAPHYLOCOCCAL PROTEIN A MUTANT - Q9W ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280; GENE: SPA; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG3; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: ROSETTAGAMI 2 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.28A 19.80% FC 04-MAY-15 20150504 IMMUNE SYSTEM IGG1 FC - FCGAMMARI ECD COMPLEX ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR1A, FCG1, FCGR1, IGFR1; EXPRESSION_SYSTEM: MAMMALIAN EXPRESSION VECTOR PCK146; EXPRESSION_SYSTEM_TAXID: 943932; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: MAMMALIAN EXPRESSION VECTOR PBGSA; EXPRESSION_SYSTEM_TAXID: 285261 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.42A 20.30% FC 04-MAY-15 20150504 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF MERS - CORONAVIRUS SPIKE RECEPTOR - BINDING DOMAIN (ENGLAND1 STRAIN) IN COMPLEX WITH VACCINE - ELICITED MURINE NEUTRALIZING ANTIBODY D12 (CRYSTAL FORM 1) MOLECULE: SPIKE GLYCOPROTEIN; FRAGMENT: RECEPTOR - BINGING DOMAIN, UNP RESIDUES 381 - 588; SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDINNYLN 7 YTSRLHS 9 QQANTLPPT 5 SYAMS 17 TISSGGTYTYYPDSVKG 7 DGNSMDY crystal 2.59A 20.60% ? 08-MAY-15 20150508 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF MERS - CORONAVIRUS SPIKE RECEPTOR - BINDING DOMAIN (ENGLAND1 STRAIN) IN COMPLEX WITH VACCINE - ELICITED MURINE NEUTRALIZING ANTIBODY D12 (CRYSTAL FORM 2) MOLECULE: SPIKE GLYCOPROTEIN; FRAGMENT: UNP RESIDUES 381 - 588; SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDINNYLN 7 YTSRLHS 9 QQANTLPPT 5 SYAMS 17 TISSGGTYTYYPDSVKG 7 DGNSMDY crystal 3.20A 22.60% ? 08-MAY-15 20150508 IMMUNE SYSTEM RECEPTOR BINDING DOMAIN AND FAB COMPLEX MOLECULE: S PROTEIN; FRAGMENT: RECEPTOR BINDING DOMAIN, UNP RESIDUES 361 - 589; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDINSFLA 7 GASNLET 8 QQYDKLPT 5 DYYMN 17 YISSSSGYTNYGDSVKG 12 DRDDFWSGYYKH crystal 3.17A 20.60% FAB 13-MAY-15 20150513 IMMUNE SYSTEM STRUCTURAL MIMICRY OF RECEPTOR INTERACTION BY ANTAGONISTIC IL - 6 ANTIBODIES MOLECULE: INTERLEUKIN - 6; FRAGMENT: RESIDUES 14 - 184; SYNONYM: IL - 6,B - CELL STIMULATORY FACTOR 2,BSF - 2,CTL DIFFERENTIATION FACTOR,CDF,HYBRIDOMA GROWTH FACTOR,INTERFERON BETA - 2,IFN - BETA - 2; ENGINEERED: YES; ? ? LAMA GLAMA 14 AGANNDIGTYAYVS 7 KVTTRAS 10 ASYRNFNNAV 7 TRYYAWS 16 VIDYDGDTYYSPSLKS 12 DPDVVTGFHYDY crystal 2.93A 26.50% FAB 13-MAY-15 20150513 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A COMPLEX BETWEEN B7 - H6, A TUMOR CELL LIGAND FOR NATURAL CYTOTOXICITY RECEPTOR NKP30, AND AN INHIBITORY ANTIBODY MOLECULE: NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3 LIGAND 1; SYNONYM: B7 HOMOLOG 6,B7 - H6; ENGINEERED: YES ? ? HOMO SAPIENS 10 CSASSSVSYM 7 YLTSNLA 10 CQQWSSNPLT 5 SYNMH 17 AIYPGNGDTSYNQKFKG 12 EGLGALLRDLYY crystal 2.50A 22.60% ? 13-MAY-15 20150513 IMMUNE SYSTEM FAB / EPITOPE COMPLEX STRUCTURE OF RABBIT MONOCLONAL ANTIBODY R53 TARGETING AN EPITOPE IN HIV - 1 GP120 C4 REGION MOLECULE: EPITOPE OF RABBIT MONOCLONAL ANTIBODY R53; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 11 QASQAIDEYLG 7 YASTLAS 14 QNYYVGSSTNYAFT 6 SFYYMC 18 CIVTDITGESYYATWAKG 15 GDTYGYGDTVYALNL crystal 2.30A 17.00% FAB 14-MAY-15 20150514 IMMUNE SYSTEM FAB STRUCTURE OF RABBIT MONOCLONAL ANTIBODY R53 TARGETING AN EPITOPE IN HIV - 1 GP120 C4 REGION ? ? ? ORYCTOLAGUS CUNICULUS 11 QASQAIDEYLG 7 YASTLAS 14 QNYYVGSSTNYAFT 6 SFYYMC 18 CIVTDITGESYYATWAKG 15 GDTYGYGDTVYALNL crystal 1.63A 19.60% FAB 14-MAY-15 20150514 HORMONE RECEPTOR / IMMUNE SYSTEM STRUCTURE OF THE HUMAN INSULIN RECEPTOR ECTODOMAIN, IRDELTABETA CONSTRUCT, IN COMPLEX WITH FOUR FAB MOLECULES MOLECULE: INSULIN RECEPTOR; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNFLA 7 WASTRES 8 QQYFRYRT 5 NYDIH 17 WIYPGDGSTKYNEKFKG 4 EWAY crystal 3.30A 20.70% FAB 20-MAY-15 20150520 IMMUNE SYSTEM CRYSTAL STRUCTURE OF QUATERNARY - SPECIFIC RSV - NEUTRALIZING HUMAN ANTIBODY AM14 MOLECULE: AM14 LIGHT CHAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDIKKYLN 7 DASNLET 10 QQYDNLPPLT 5 HYAMH 17 VISYDGENTYYADSVKG 11 DRIVYYYGMDV crystal 2.00A 18.80% FAB 21-MAY-15 20150521 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOTAVIZUMAB AND QUATERNARY - SPECIFIC RSV - NEUTRALIZING HUMAN ANTIBODY AM14 IN COMPLEX WITH PREFUSION RSV F GLYCOPROTEIN MOLECULE: FUSION GLYCOPROTEIN F0,FIBRITIN; SYNONYM: PROTEIN F; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSRVGYMH 7 DTSKLAS 9 FQGSGYPFT 7 TAGMSVG 16 DIWWDDKKHYNPSLKD 10 DMIFNFYFDV crystal 5.50A 21.40% FAB 21-MAY-15 20150521 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB4201 RAISED AGAINST HUMAN ERYTHROCYTE ANION EXCHANGER 1 ? ? ? MUS MUSCULUS 15 RASQSVSTSSYSYMN 7 YASNLES 9 QHSWEIPWT 7 TSGIGVG 16 HIWWSASKYYNTALKS 13 AYYGNYGGYYFDY crystal 2.50A 21.49% FAB 28-APR-15 20150428 VIRUS CRYO - EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 STRAIN PVP94 - 07 COMPLEXED WITH HUMAN ANTIBODY 2D22 FAB AT 37 DEGREES C MOLECULE: MEMBRANE GLYCOPROTEIN; FRAGMENT: RESIDUES 92 - 163; SYNONYM: M PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNVGSNYVY 7 RNNRRPS 11 ATWDDSLSGLV 5 NYAIS 17 GIIPIFGGANYAQKFQG 12 RPQSIFDWNFDL ElectronMicroscopy N/A N/A FAB 06-MAY-15 20150506 VIRAL PROTEIN CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN FLD194 FAB AND TRANSMISSIBLE MUTANT H5 HAEMAGGLUTININ MOLECULE: HEMAGGLUTININ; FRAGMENT: HA1 OF TRYPSIN RELEASED ECTODOMAIN, RESIDUES 347 - 512; SYNONYM: HAEMAGGLUTININ HA1; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLLHGNGYNYLD 7 LGSNRAS 9 MQALQTPLT 5 DYWIG 17 IIYPASSEIRYSPSFQG 16 HASCSARSCYWGPVDY crystal 2.89A 24.55% FAB 01-JUN-15 20150601 VIRAL PROTEIN NEGATIVE STAIN EM OF BG505 SOSIP.664 IN COMPLEX WITH SCD4, 17B, AND 8ANC195 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDKWSGLHHDGVMAFSS ElectronMicroscopy N/A N/A ? 10-JUL-15 20150710 VIRAL PROTEIN / IMMUNE SYSTEM CRYO - ET SUBTOMOGRAM AVERAGING OF BG505 SOSIP.664 IN COMPLEX WITH SCD4, 17B, AND 8ANC195 MOLECULE: T - CELL SURFACE GLYCOPROTEIN CD4; FRAGMENT: SOLUBLE CD4 D1 - D2 DOMAINS, RESIDUES26 - 208; SYNONYM: T - CELL SURFACE ANTIGEN T4 / LEU - 3, CD4; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH ElectronMicroscopy N/A N/A ? 15-JUL-15 20150715 IMMUNE SYSTEM STRUCTURE OF A REDESIGNED CROSS - REACTIVE ANTIBODY TO DENGUE VIRUS WITH INCREASED IN VIVO POTENCY MOLECULE: ENVELOPE PROTEIN; FRAGMENT: RESIDUES 2 - 109; SYNONYM: DENGUE SEROTYPE 4 ENVELOPE PROTEIN DOMAIN III; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.49A 22.22% scFv 27-JUL-15 20150727 VIRAL PROTEIN STRUCTURE OF A REDESIGNED CROSS - REACTIVE ANTIBODY TO DENGUE VIRUS WITH INCREASED IN VIVO POTENCY MOLECULE: DENGUE SEROTYPE 4 ENVELOPE PROTEIN DOMAIN 3; FRAGMENT: D3; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 3.27A 22.85% scFv 30-JUL-15 20150730 IMMUNE SYSTEM MCG IMMUNOGLOBULIN VARIABLE DOMAIN WITH SULFASALAZINE ? LAMBDA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; TISSUE: BLOOD; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3) 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 1.49A 16.00% LC-dimer 17-AUG-15 20150817 IMMUNE SYSTEM MCG IMMUNOGLOBULIN VARIABLE DOMAIN WITH METHYLENE BLUE MOLECULE: MCG; FRAGMENT: IG LAMBDA CHAIN V - II REGION MGC; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 1.05A 11.10% LC-dimer 17-AUG-15 20150817 VIRAL PROTEIN CRYO - EM STRUCTURE OF PGT128 FAB IN COMPLEX WITH BG505 SOSIP. 664 ENV TRIMER MOLECULE: HIV - 1 ENVELOPE GLYCOPROTEIN; FRAGMENT: GP41, RESIDUES 509 - 661; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: THE ENV SEQUENCE IS FROM THE CLADE A VIRUS BG505, TRUNCATED AT RESIDUE 664 OF GP41, MUTATED TO HAVE THE N332 GLYCOSYLATION SITE, AND CONTAINS STABILIZING SOSIP MUTATIONS.; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A FAB 17-AUG-15 20150817 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE PARAOXON - MODIFIED A.17 ANTIBODY FAB FRAGMENT - LIGHT CHAIN S35R MUTANT ? ? ? HOMO SAPIENS 13 SGSSSNIGNNYVR 7 DNNKRPS 10 GTWDSSLNPV 6 SGYYWG 16 SIYHSGSTYYNPSLKS 6 LTNDAN crystal 1.55A 17.00% FAB 21-AUG-15 20150821 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE A.17 ANTIBODY FAB FRAGMENT - LIGHT CHAIN S35R MUTANT ? ? ? HOMO SAPIENS 13 SGSSSNIGNNYVR 7 DNNKRPS 10 GTWDSSLNPV 6 SGYYWG 16 SIYHSGSTYYNPSLKS 4 LTAN crystal 2.13A 18.10% FAB 21-AUG-15 20150821 IMMUNE SYSTEM TICAGRELOR ANTIDOTE CANDIDATE MEDI2452 IN COMPLEX WITH TICAGRELOR MOLECULE: MEDI2452 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSNSDIGNNYVS 7 DNNKRPS 11 GTWLYDRAVGL 5 SYSIH 17 GIIPAFGTLSSAQDFQA 20 GSFDYYFWSASHPPNDALAI crystal 2.16A 21.62% ? 07-MAR-15 20150307 IMMUNE SYSTEM TICAGRELOR ANTIDOTE CANDIDATE FAB 72 IN COMPLEX WITH TICAGRELOR WITH TICAGRELOR ? ? HOMO SAPIENS 13 SGSNSDIGNNYVS 7 DNNKRPS 11 GTWDISLSAGL 5 SYSIH 17 GIIPAFGTLSSAQDFQA 12 GSHLYPNDALAI crystal 1.70A 19.95% FAB 07-MAR-15 20150307 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IGE FC IN COMPLEX WITH A NEUTRALIZING ANTIBODY ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-EBNA; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHINESE HAMSTER OVARY-EBNA; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHINESE HAMSTER OVARY-EBNA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.85A 19.88% FC 07-SEP-15 20150907 VIRUS ELECTRON CRYO - MICROSCOPY OF CHIKUNGUNYA VIRUS IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB CHK265 MOLECULE: E2; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSNIGAVTSSNCAN 7 DTNNRRS 9 ALWYNNLWV 5 EYPML 17 LIYTNTGEPTYAEEFKG 8 DYFISLDY ElectronMicroscopy N/A N/A FAB 08-SEP-15 20150908 IMMUNE SYSTEM / PEPTIDE CRYSTAL STRUCTURE OF A FAB FRAGMENT WITH THE LIGAND PEPTIDE MOLECULE: PEPTIDE RENLYFQGKDG; ENGINEERED: YES; OTHER_DETAILS: THE MODIFIED TEV PROTEASE RECOGNITION SEQUENCE ? ? RATTUS 16 RSSQSLLHRNGNTYLN 7 LVSRLES 9 VQGTHAPLT 7 FSNVAMY 19 RIRTKPNNYATYYADSVKG 5 EVATD crystal 2.05A 19.10% FAB 30-APR-15 20150430 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - HIV - 1 BROADLY NEUTRALIZING ANTIBODY 3BC176 FAB ? ? ? HOMO SAPIENS 14 TGSRNDVGGYDFVS 7 EISKRPS 10 CSYASYDRLI 5 DYHIH 17 WIDPVGGITKYAGQFQG 19 SMRPVDHGIDYSGLFVFHF crystal 1.89A 18.00% FAB 06-JUL-15 20150706 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF 9E5, A MURINE MONOCLONAL ANTIBODY SPECIFIC FOR HUMAN EPIREGULIN ? ? ? MUS MUSCULUS 11 KASQDINKYIA 7 YTSTLHP 8 LQYDNLRT 5 DTYMH 17 RIDPLNDKTKYDPKFQG 9 GGGDPVFVY crystal 1.60A 19.50% FAB 16-SEP-15 20150916 IMMUNE SYSTEM FAB FRAGMENT OF CALCIUM - DEPENDENT ANTIGEN BINDING ANTIBODY, 6RL#9 ? ? ? HOMO SAPIENS 5 TGDVH 7 HNTHRPS 11 QSHDSSLSAVV 5 SYYMH 17 IINPSGGSTSYAQKFQG 12 DDPGGGEYYFDY crystal 2.20A 21.50% FAB 02-OCT-15 20151002 IMMUNE SYSTEM STRUCTURE OF MONOMERIC MUTANT OF REI IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN MOLECULE: IG KAPPA CHAIN V - I REGION REI; ENGINEERED: YES; MUTATION: YES KAPPA ? HOMO SAPIENS 11 QASQDIIKYLN 7 EASNLQA 9 QQYQSLPKT 0 N/A 0 N/A 0 N/A crystal 2.88A 18.80% LC-dimer 14-FEB-16 20160214 TRANSPORT PROTEIN ACTIVATION OF NMDA RECEPTORS AND THE MECHANISM OF INHIBITION BY IFENPRODIL MOLECULE: NMDA GLUTAMATE RECEPTOR SUBUNIT; FRAGMENT: UNP RESIDUES 23 - 405; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDINKYIA 7 YTSTLQP 8 LQYDNLYT 5 SYSMS 17 YISNGGSGTYYPDTVKG 13 PSRGGSSYWYFDV crystal 2.90A 27.50% FAB 01-MAR-16 20160301 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN FAB AGAINST HUMAN INFLUENZA A ? ? ? MUS MUSCULUS 15 KASQSVDYDGDSYVT 7 VASNLES 9 QQSNEDPWT 5 RYYMS 17 AINHNSGRTYYSDTVKG 12 HPLIYHGNYLDY crystal 2.40A 28.80% FAB 05-APR-16 20160405 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF AN ANTI - LEUKOTRIENE C4 MONOCLONAL ANTIBODY COMPLEXED WITH LTC4 LTC4 KAPPA ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSKYVPYT 5 NYWMN 19 EIRLKSNNYVTHYAESVKG 7 IYSPFAY crystal 2.10A 19.70% FAB 27-MAY-16 20160527 IMMUNE SYSTEM CRYSTAL STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH SKY59 MOLECULE: COMPLEMENT C5 BETA CHAIN; FRAGMENT: UNP RESIDUES 20 - 124; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGISSSLA 7 GASETES 12 QNTKVGSSYGNT 6 SSYYMA 17 AIFTGSGAEYKAEWAKG 13 DAGYDYPTHAMHY crystal 2.11A 24.80% FAB 03-JUN-16 20160603 IMMUNE SYSTEM HIGH RESOLUTION STRUCTURE OF THE HUMAN PD - 1 IN COMPLEX WITH PEMBROLIZUMAB FV MOLECULE: PROGRAMMED CELL DEATH PROTEIN 1; SYNONYM: HPD - 1; ENGINEERED: YES ? ? HOMO SAPIENS 15 RASKGVSTSGYSYLH 7 LASYLES 9 QHSRDLPLT 5 NYYMY 17 GINPSNGGTNFNEKFKN 11 RDYRFDMGFDY crystal 2.15A 18.60% FV 14-JUN-16 20160614 SUGAR BINDING PROTEIN CRYSTAL STRUCTURE OF MALTOSE BINDING PROTEIN IN COMPLEX WITH AN ALLOSTERIC SYNTHETIC ANTIBODY MOLECULE: MALTOSE - BINDING PERIPLASMIC PROTEIN; SYNONYM: MBP,MMBP,MALTODEXTRIN - BINDING PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 10 QQASLTALLT 5 SSSIH 17 SIYSYYGSTSYADSVKG 18 EYHSYWSYSWWPRVGLDY crystal 1.95A 19.60% FAB 12-SEP-17 20170912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 663 FAB BOUND TO CIRCUMSPOROZOITE PROTEIN NANP 5 - MER MOLECULE: CIRCUMSPOROZOITE PROTEIN NANP 5 - MER; ENGINEERED: YES ? ? HOMO SAPIENS 15 RSTQSLIFGEHNYLD 7 LASNRAS 9 VQTVQVPYT 5 NYAFN 17 IIYRSGSRMYHADSVKG 12 LLIYESDVGVDF crystal 3.15A 23.70% FAB 12-SEP-17 20170912 SUGAR BINDING PROTEIN CRYSTAL STRUCTURE OF MALTOSE BINDING PROTEIN IN COMPLEX WITH AN ENDOSTERIC SYNTHETIC ANTIBODY MOLECULE: MALTOSE BINDING PROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 10 QQSPQGYLVT 5 YSSIH 17 SIYSYYGSTSYADSVKG 16 EYHSYVYEPPLYGMDY crystal 2.15A 20.80% FAB 12-SEP-17 20170912 SUGAR BINDING PROTEIN CRYSTAL STRUCTURE OF MALTOSE BINDING PROTEIN IN COMPLEX WITH A PERISTERIC SYNTHETIC ANTIBODY MOLECULE: MALTOSE - BINDING PERIPLASMIC PROTEIN; SYNONYM: MBP,MMBP,MALTODEXTRIN - BINDING PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 CRASQSVSSAV 7 YSASSLY 11 CQQYYYGYPIT 6 YSSSIH 17 ASISSYSGYTSYADSVK 18 RYKYPYWSWYYYWGGMDY crystal 2.60A 21.40% FAB 12-SEP-17 20170912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEUTRALIZING ANTI - CIRCUMSPOROZOITE PROTEIN 580 ANTIBODY ? ? ? HOMO SAPIENS 17 KSSQSVFFSSNNRTYFA 7 WASTRES 9 QQYYSSPIT 5 HYAMS 17 GISGGGESTNYADSVKG 16 DPGGDSSPAGRTWFDP crystal 2.80A 19.10% FAB 12-SEP-17 20170912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - CIRCUMSPOROZOITE PROTEIN 663 GERMLINE ANTIBODY ? ? ? HOMO SAPIENS 16 RSSQSLLHSNGYNYLD 7 LGSNRAS 9 MQALQTPYT 4 YAMS 17 VIYSGGSSTYYADSVKG 12 LLILESDVGVDY crystal 3.00A 26.00% FAB 12-SEP-17 20170912 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A THEOPHYLLINE BINDING ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 16 RSSQSIVYNNRYTYLE 7 GVSNRFS 9 YQGTHAPYT 6 SDYAWN 16 YIRYSGHTGYNPSLKS 7 WVDYFDY crystal 2.80A 18.80% FAB 22-MAY-15 20150522 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMAN JAG1 FRAGMENT IN COMPLEX WITH AN ANTI - JAG1 FAB MOLECULE: PROTEIN JAGGED - 1; FRAGMENT: UNP RESIDUES 186 - 335; SYNONYM: HJ1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQYYTTATT 5 NYGIH 17 WITPDGGYTDYADSVKG 7 AGTLFAY crystal 2.56A 22.20% FAB 26-MAY-15 20150526 DE NOVO PROTEIN CRYSTAL STRUCTURE OF THE ARTIFICIAL NANOBODY OCTARELLINV.1 COMPLEX ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PMES4; MOL_ID: 2; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PJB122 0 0 0 0 0 0 crystal 1.95A 19.40% Nanobody 27-MAY-15 20150527 HYDROLASE / IMMUNE SYSTEM RICIN A CHAIN BOUND TO CAMELID NANOBODY (VHH9) (E1) MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 39 - 298; EC: 3.2.2.22; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 4 RSSM 17 ASIVWADGTTLYGDSVK 18 DNKFVRGLVAVRAIDYDY crystal 3.10A 21.80% HC-dimer 27-MAY-15 20150527 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS - HUMAN FAB 5F - 10 FRAGMENT ? ? ? HOMO SAPIENS 6 TSSNVH 7 VNSNRPS 7 QSYGSAV 5 RYAMT 17 WINTYTGNPTYVQGFTG 9 EGGARGFDY crystal 2.74A 23.80% FAB 28-MAY-15 20150528 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN LCAT (L4F, N5D) IN COMPLEX WITH FAB OF AN AGONISTIC ANTIBODY MOLECULE: PHOSPHATIDYLCHOLINE - STEROL ACYLTRANSFERASE; SYNONYM: LECITHIN - CHOLESTEROL ACYLTRANSFERASE,PHOSPHOLIPID - CHOLESTEROL ACYLTRANSFERASE; EC: 2.3.1.43; MUTATION: YES; ? ? HOMO SAPIENS 11 SGDKLGNKFTS 7 QDTKRPS 10 QAWDSSTAWV 5 SYGMH 17 VIWYDGSNKFYEDSVKG 17 EGAAVRSFYYSYYGMDV crystal 2.45A 19.10% FAB 04-JUN-15 20150604 IMMUNE SYSTEM THE MOLECULAR MODE OF ACTION AND SPECIES SPECIFICITY OF CANAKINUMAB, A HUMAN MONOCLONAL ANTIBODY NEUTRALIZING IL - 1BETA ? ? ? HOMO SAPIENS 11 RASQSIGSSLH 7 YASQSFS 9 HQSSSLPFT 5 VYGMN 17 IIWYDGDNQYYADSVKG 9 DLRTGPFDY crystal 2.00A 18.60% FAB 05-JUN-15 20150605 IMMUNE SYSTEM THE MOLECULAR MODE OF ACTION AND SPECIES SPECIFICITY OF CANAKINUMAB, A HUMAN MONOCLONAL ANTIBODY NEUTRALIZING IL - 1BETA MOLECULE: INTERLEUKIN - 1 BETA; FRAGMENT: FAB HEAVY - CHAIN, UNP RESIDUES 117 - 269; SYNONYM: IL - 1 BETA,CATABOLIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGSSLH 7 YASQSFS 9 HQSSSLPFT 5 VYGMN 17 IIWYDGDNQYYADSVKG 9 DLRTGPFDY crystal 2.20A 19.00% FAB 05-JUN-15 20150605 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NONFUCOSYLATED FC Y296W MUTANT COMPLEXED WITH BIS - GLYCOSYLATED SOLUBLE FORM OF FC GAMMA RECEPTOR IIIA ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: MS704; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX2160; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A, CD16A, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX93 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.00A 20.60% FC 06-JUN-15 20150606 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PCDN - 27A, AN ANTIBODY FROM THE PCDN FAMILY OF HIV - 1 ANTIBODIES ? ? ? HOMO SAPIENS 12 RASQSVSARNLA 7 GVSIRNT 8 QQYGDSPT 5 AFSWS 16 EIDHTGSANYNPSLKS 20 GGRKVYHAYWSGYVNNCFDP crystal 2.70A 21.30% FAB 11-JUN-15 20150611 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PCDN - 27B, AN ANTIBODY FROM THE PCDN FAMILY OF HIV - 1 ANTIBODIES EIVLTQSPGTLSLSPGERATLSCRASQSVSAKNLAWYQQKPGQTPRLLMYGVSLRNTGVP DRFSGSGSGTDFTLTISRLEPEDSAVYFCQQYGTSPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGT ASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGEC; ? ? HOMO SAPIENS 12 RASQSVSAKNLA 7 GVSLRNT 8 QQYGTSPT 6 SAFSWS 16 EIDHTTSSNYNPSLKR 20 GGRKVYHAYWSGYVNNCFDP crystal 2.90A 23.60% FAB 11-JUN-15 20150611 LIPID TRANSPORT DEVELOPMENT OF A MONOCLONAL ANTIBODY TARGETING SECRETED AP2 TO TREAT DIABETES AND FATTY LIVER DISEASE MOLECULE: FATTY ACID - BINDING PROTEIN, ADIPOCYTE; SYNONYM: AP2,3T3 - L1 LIPID - BINDING PROTEIN,ADIPOCYTE LIPID - BINDING PROTEIN,ALBP,ADIPOCYTE - TYPE FATTY ACID - BINDING PROTEIN,AFABP,FATTY ACID - BINDING PROTEIN 4,MYELIN P2 PROTEIN HOMOLOG,P15,P2 ADIPOCYTE PROTEIN,PROTEIN 422; ENGINEERED: YES; ? ? ORYCTOLAGUS CUNICULUS 11 QASEDISRYLV 7 KASTLAS 14 QCTYGTYAGSFFYS 0 N/A 0 N/A 0 N/A crystal 3.00A 19.40% LC-dimer 12-JUN-15 20150612 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A GENERATION 3 INFLUENZA HEMAGGLUTININ STABILIZED STEM COMPLEXED WITH THE BROADLY NEUTRALIZING ANTIBODY C179 MOLECULE: HEMAGGLUTININ, ENVELOPE GLYCOPROTEIN, FIBRITIN FUSION PROTEIN; FRAGMENT: UNP Q6WG00 RESIDUES 18 - 49, 328 - 402, 436 - 517, UNP P04578 RESIDUES 546 - 577, 628 - 654 AND UNP D9IEJ2 RESIDUES 458 - 485; ENGINEERED: YES; ? ? MUS MUSCULUS 11 LASQTIGTWLA 7 AATSLAD 9 QQLYSTPWT 5 DDYMT 19 FIRDRANGYTTEYSASVKG 11 PKGYFPYAMDY crystal 3.19A 20.20% FAB 12-JUN-15 20150612 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A GENERATION 4 INFLUENZA HEMAGGLUTININ STABILIZED STEM IN COMPLEX WITH THE BROADLY NEUTRALIZING ANTIBODY CR6261 MOLECULE: HEMAGGLUTININ, ENVELOPE GLYCOPROTEIN, FIBRITIN FUSION PROTEIN; FRAGMENT: UNP Q6WG00 RESIDUES 18 - 49, 328 - 402, 436 - 517, UNP P04578 RESIDUES 546 - 577, 628 - 654 AND UNP D9IEJ2 RESIDUES 458 - 485; SYNONYM: ENV POLYPROTEIN,ENV POLYPROTEIN; ENGINEERED: YES; OTHER_DETAILS: ENGINEERED FUSION BETWEEN AN INFLUENZA HEMAGGLUTININ STEM, AN HIV - 1 GP41 SIX - HELIX BUNDLE AND T4 PHAGE FOLDON; ? ? HOMO SAPIENS 13 SGSSSNIGNDYVS 7 DNNKRPS 12 ATWDRRPTAYVV 5 SYAIS 17 GIIPIFGTTKYAPKFQG 12 HMGYQVRETMDV crystal 4.30A 24.10% ? 12-JUN-15 20150612 SIGNALING PROTEIN / ANTAGONIST CRYSTAL STRUCTURE OF ACTIVE MU - OPIOID RECEPTOR BOUND TO THE AGONIST BU72 MOLECULE: MU - TYPE OPIOID RECEPTOR; SYNONYM: MOR - 1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 3 PMG 17 SITWSGIDPTYADSVAD 8 RAPVDYDY crystal 2.10A 18.70% HC-dimer 15-JUN-15 20150615 TRANSPORT PROTEIN FERREDOXIN - LIKE DOMAIN OF NUCLEOPORIN NUP54 BOUND TO A NANOBODY MOLECULE: NUP54; FRAGMENT: NUP54 FERREDOXIN - LIKE DOMAIN, UNP RESIDUES 212 - 349; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 2 IG 17 AISSRDGSTYYPDAVKG 19 DRRQRWGPYYYLSALEYVY crystal 1.55A 17.80% HC-dimer 16-JUN-15 20150616 TRANSPORT PROTEIN STRUCTURE OF THE METAZOAN NUP62.NUP58.NUP54 NUCLEOPORIN COMPLEX. MOLECULE: NUCLEOPORIN NUP58; FRAGMENT: COILED COIL; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 NYAMS 17 DIGSGGDRITYADSVKG 3 QYG crystal 2.90A 26.60% HC-dimer 17-JUN-15 20150617 VIRAL PROTEIN / IMMUE SYSTEM CRYSTAL STRUCTURE OF HCMV GLYCOPROTEIN B IN COMPLEX WITH 1G2 FAB MOLECULE: ENVELOPE GLYCOPROTEIN B; SYNONYM: GB; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIETNYVS 7 RNNQRPS 9 GTWDDNSWV 7 RSTYYWG 16 NIYYNGRAVYSPSLKS 10 RWNYFFDFDY crystal 3.60A 21.40% FAB 23-JUN-15 20150623 IMMUNE SYSTEM CRYSTAL STRUCTURE BG505 SOSIP GP140 HIV - 1 ENV TRIMER BOUND TO BROADLY NEUTRALIZING ANTIBODIES PGT128 AND 8ANC195 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; FRAGMENT: UNP RESIDUES 30 - 507; ENGINEERED: YES; ? ? HOMO SAPIENS 9 TGTSNNFVS 7 DVNKRPS 10 GSLVGNWDVI 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDKWSGLHHDGVMAFSS crystal 4.60A 29.00% FAB 24-JUN-15 20150624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOR04357, A NEUTRALIZING ANTI - HUMAN GM - CSF ANTIBODY FAB FRAGMENT IN COMPLEX WITH HUMAN GM - CSF MOLECULE: GRANULOCYTE - MACROPHAGE COLONY - STIMULATING FACTOR; FRAGMENT: UNP RESIDUES 18 - 144; SYNONYM: GM - CSF,COLONY - STIMULATING FACTOR,CSF,MOLGRAMOSTIN, SARGRAMOSTIM; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDSIGKKYAY 2 KK 9 SAWGDKGMV 5 SYWMN 19 GIENKYAGGATYYAASVKG 6 GFGTDF crystal 2.95A 23.40% FAB 25-JUN-15 20150625 MEMBRANE PROTEIN A YIDC - LIKE PROTEIN IN THE ARCHAEAL PLASMA MEMBRANE MOLECULE: PROTEIN MJ0480; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSSRPVT 6 SSSSIH 17 ASISPSYGYTYYADSVK 20 RGIWSYWYMVYPHDNYGMDY crystal 3.50A 25.60% ? 25-JUN-15 20150625 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HIGHLY FIBRILLOGENIC ARG24GLY MUTANT OF THE RECOMBINANT VARIABLE DOMAIN 6AJL2 MOLECULE: AMYLOID LAMBDA 6 LIGHT CHAIN VARIABLE REGION PIP; ENGINEERED: YES; MUTATION: YES LAMBDA ? HOMO SAPIENS 13 TGSSGSIASNYVQ 7 EDNQRPS 12 YCQSYDSSNHVV 0 N/A 0 N/A 0 N/A crystal 1.92A 17.30% LC-dimer 27-JUN-15 20150627 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - HIV - 1 BROADLY NEUTRALIZING ANTIBODY 3BC315 FAB ? ? ? HOMO SAPIENS 14 SGTRSDVGGYDFVS 7 EVTKRPS 10 CSYANYDKLI 5 DYYMH 17 WVNTNGGFTKYGAKFQG 19 PMRPVSHGIDYSGLFVFQF crystal 1.95A 16.00% FAB 02-JUL-15 20150702 IMMUNE SYSTEM STRUCTURE OF IMMATURE VRC01 - CLASS ANTIBODY DRVIA7 MOLECULE: DRVIA7 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQRIDNWVA 7 KASILET 5 QQFEE 5 SSFIH 17 WMNPRHGAVNYPRRFQG 11 SRTKDYDWDFV crystal 2.90A 23.70% ? 02-JUL-15 20150702 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN IMMATURE VRC01 - CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A / E HIV - 1 GP120 CORE MOLECULE: 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQRIDNWVA 7 KASILET 5 QQFEE 5 SSFIH 17 WMNPRHGAVNYPRRFQG 11 SRTKDYDWDFV crystal 3.40A 26.90% FAB 03-JUL-15 20150703 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 32H+109L, A PUTATIVE PRECURSOR OF THE PGT121 FAMILY OF POTENT HIV - 1 ANTIBODIES ? ? ? HOMO SAPIENS 11 GGRSLGSRAVQ 7 NNQDRPS 15 YYCHMWDSRSAINWV 5 DHYWS 16 YVYDSGDTNYNPSLKS 24 TQHGRRIYGIVAFREWFTYFYMDV crystal 2.11A 20.20% FAB 07-JUL-15 20150707 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB 9H+3L, A PUTATIVE PRECURSOR OF THE PGT121 FAMILY OF POTENT HIV - 1 ANTIBODIES ? ? ? HOMO SAPIENS 11 GRQALGSRAVQ 7 NNQDRPS 12 HMWDSRSGFSWS 5 NYYWT 16 YISDRETTTYNPSLKS 24 ARRGQRIYGVVSFGEFFYYYYMDV crystal 2.39A 22.70% FAB 07-JUL-15 20150707 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV - 1 ENV TRIMER IN COMPLEX WITH AN EARLY PUTATIVE PRECURSOR OF THE PGT121 FAMILY AT 3.0 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 509 - 661; SYNONYM: ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 13 - 1 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 18 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 19 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 21 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 25 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 6 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 7 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 8 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 9 ENV POLYPROTEIN,ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.03A 23.50% FAB 08-JUL-15 20150708 IMMUNE SYSTEM FAB FRAGMENT OF CHIKUNGUNYA VIRUS NEUTRALIZING HUMAN MONOCLONAL ANTIBODY 4J21 ? ? ? HOMO SAPIENS 13 SGGSSNIGSNPVN 7 TNNQRPS 12 AVWDDSLSGRWV 5 SYSIN 17 WIDTNTGNPTYAQDFAG 18 YYVDLWGSYRQDYYGMDV crystal 2.07A 16.90% FAB 09-JUL-15 20150709 IMMUNE SYSTEM FAB FRAGMENTS OF CHIKUNGUNYA VIRUS NEUTRALIZING HUMAN MONOCLONAL ANTIBODY 5M16 ? ? ? HOMO SAPIENS 16 KSSQSLLHSDGKTYLY 7 EVSNRLS 10 MQSIQVPLYT 5 SYFMH 17 ITYPGGGSPSYAPQFQG 13 GAHRSIGTTPLDS crystal 2.05A 17.40% FAB 10-JUL-15 20150710 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NON - NEUTRALIZING VERSION OF 4E10 (WDWD) WITH EPITOPE BOUND MOLECULE: PEPTIDE FROM THE MPER REGION OF THE ENV PROTEIN OF HIV - 1; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGDGDLGKPIGAFAH crystal 1.81A 16.40% FAB 13-JUL-15 20150713 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NON - NEUTRALIZING VERSION OF 4E10 (DELTALOOP) WITH EPITOPE BOUND MOLECULE: PEPTIDE FROM MPER REGION OF HIV - 1 ENV; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 16 EGTTGSGGKPIGAFAH crystal 1.70A 14.90% FAB 13-JUL-15 20150713 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNBOUND 4E10 ? ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 18 EGTTGWGWLGKPIGAFAH crystal 2.48A 18.50% FAB 13-JUL-15 20150713 HYDROLASE / HYDROLASE INHIBITOR CRYSTAL STRUCTURE ANALYSIS OF ELBOW - ENGINEERED - FAB - BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INSULIN MOLECULE: INSULIN; ENGINEERED: YES ? ? MUS MUSCULUS 8 RAVSSAVA 6 SSSLYS 10 QQSSPSFLIT 5 SYSIH 17 SISSYYGSTSYADSVKG 20 DRVMYYWSFSKYGYPYGMDY crystal 3.29A 19.90% FAB 14-JUL-15 20150714 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A TRIMERIC INFLUENZA HEMAGGLUTININ STEM IN COMPLEX WITH AN BROADLY NEUTRALIZING ANTIBODY CR9114 MOLECULE: DESIGNED INFLUENZA HEMAGGLUTININ STEM #4900, HA2; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 NYAIS 17 GISPIFGSTAYAQKFQG 12 HGNYYYYSGMDV crystal 3.60A 34.70% ? 14-JUL-15 20150714 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOMERIC INFLUENZA HEMAGGLUTININ STEM IN COMPLEX WITH AN BROADLY NEUTRALIZING ANTIBODY CR9114 MOLECULE: DESIGNED INFLUENZA HEMAGGLUTININ STEM #4454, HA1; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 NYAIS 17 GISPIFGSTAYAQKFQG 12 HGNYYYYSGMDV crystal 4.30A 26.40% ? 15-JUL-15 20150715 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF 8ANC195 FAB IN COMPLEX WITH BG505 SOSIP.664 HIV - 1 ENV TRIMER MOLECULE: BG505 ENV GP41; FRAGMENT: UNP RESIDUES 509 - 661; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDRWSGLHHDGVMAFSS crystal 3.58A 24.00% FAB 15-JUL-15 20150715 IMMUNE SYSTEM ANTI - B7 - H3 MONOCLONAL ANTIBODY CH8H9 FAB FRAGMENT ? ? ? MUS MUSCULUS 11 RASQSISDYLH 7 YASQSIS 9 QNGHSFPLT 5 NYDIN 17 WIFPGDGSTQYNEKFKG 9 QTTATWFAY crystal 2.50A 21.10% FAB 16-JUL-15 20150716 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTIGEN - BINDING FRAGMENT OF MONOCLONAL ANTIBODY AGAINST SULFONAMIDES IN COMPLEX WITH SULFATHIAZOLE WITH SULFATHIAZOLE ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPQT 6 SGYSWH 16 YIHYSGSTNYNPSLRG 4 YGGY crystal 1.99A 21.70% FAB 21-JUL-15 20150721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTIGEN - BINDING FRAGMENT OF MONOCLONAL ANTIBODY AGAINST SULFONAMIDES ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLN 7 LVSKLDS 9 WQGTHFPQT 6 SGYSWH 16 YIHYSGSTNYNPSLRG 4 YGGY crystal 3.01A 26.30% FAB 21-JUL-15 20150721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1 - 11 MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: UNP RESIDUES 672 - 682; SYNONYM: ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,CEREBRAL VASCULAR AMYLOID PEPTIDE,CVAP,PREA4,PROTEASE NEXIN - II,PN - II; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 LQIYNMPIT 5 SYAMS 17 AINASGTRTYYADSVKG 10 GKGYVRYFDV crystal 1.80A 19.80% FAB 23-JUL-15 20150723 TRANSFERASE CRYSTAL STRUCTURE OF SERBB3 - FAB3379 COMPLEX MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 3; SYNONYM: PROTO - ONCOGENE - LIKE PROTEIN C - ERBB - 3,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER3; EC: 2.7.10.1; ENGINEERED: YES; ? IGG HOMO SAPIENS 13 SGSLSNIGLNYVS 7 RNNQRPS 11 AAWDDSPPGEA 5 YYYMQ 17 YIGSSGGVTNYADSVKG 9 VGLGDAFDI crystal 3.20A 25.40% FAB 25-JUL-15 20150725 PROTEIN TRANSPORT CRYSTAL STRUCTURE OF THE INTACT CHAETOMIUM THERMOPHILUM NSP1 - NUP49 - NUP57 CHANNEL NUCLEOPORIN HETEROTRIMER BOUND TO ITS NIC96 NUCLEAR PORE COMPLEX ATTACHMENT SITE MOLECULE: NUCLEOPORIN NSP1; FRAGMENT: UNP RESIDUES 467 - 674; SYNONYM: NUCLEAR PORE PROTEIN NSP1,NUCLEOSKELETAL - LIKE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSSSLIT 5 SYSIH 17 SIYSYYGSTYYADSVKG 14 LTWRSYRGVHALDY crystal 3.77A 23.10% FAB 28-JUL-15 20150728 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NOTCH3 NRR IN COMPLEX WITH 20350 FAB ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: NOTCH3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-FS; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.19A 20.60% FAB 01-AUG-15 20150801 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NOTCH3 NRR IN COMPLEX WITH 20358 FAB ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: NOTCH3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.10A 19.00% FAB 01-AUG-15 20150801 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GASDALIE IGG1 FC ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.39A 24.30% FC 08-AUG-15 20150808 IMMUNE SYSTEM STRUCTURE OF 4497 FAB BOUND TO SYNTHETIC WALL TEICHOIC ACID FRAGMENT ? ? IGG1 HOMO SAPIENS 17 KSSQSIFRTSRNKNLLN 7 WASTRKS 9 QQYFSPPYT 5 SFWMH 17 FTNNEGTTTAYADSVRG 7 GDGGLDD crystal 1.72A 20.50% FAB 12-AUG-15 20150812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GASDALIE IGG1 FC IN COMPLEX WITH FCGRIIIA ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A, CD16A, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.13A 27.30% FC 12-AUG-15 20150812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOR03929, A NEUTRALIZING ANTI - HUMAN GM - CSF ANTIBODY FAB FRAGMENT IN COMPLEX WITH HUMAN GM - CSF MOLECULE: GRANULOCYTE - MACROPHAGE COLONY - STIMULATING FACTOR; SYNONYM: GM - CSF,COLONY - STIMULATING FACTOR,CSF,MOLGRAMOSTIN, SARGRAMOSTIM; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDSIGKKYAY 0 9 SSWDSTGLV 5 SYWMN 17 GISYSGSETYYADSVKG 6 GFGTDF crystal 2.06A 19.10% FAB 13-AUG-15 20150813 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOR04302, A NEUTRALIZING ANTI - HUMAN GM - CSF ANTIBODY FAB FRAGMENT IN COMPLEX WITH HUMAN GM - CSF MOLECULE: GRANULOCYTE - MACROPHAGE COLONY - STIMULATING FACTOR; SYNONYM: GM - CSF,COLONY - STIMULATING FACTOR,CSF,MOLGRAMOSTIN, SARGRAMOSTIM; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDSIGKKYAY 0 9 SAWGDKGMV 5 SYWMN 17 GISYSGSETYYADSVKG 6 GFGTDF crystal 2.25A 18.10% FAB 13-AUG-15 20150813 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOR04252, A NEUTRALIZING ANTI - HUMAN GM - CSF ANTIBODY FAB FRAGMENT IN COMPLEX WITH HUMAN GM - CSF MOLECULE: GRANULOCYTE - MACROPHAGE COLONY - STIMULATING FACTOR; SYNONYM: GM - CSF,COLONY - STIMULATING FACTOR,CSF,MOLGRAMOSTIN, SARGRAMOSTIM; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDSIGKKYAY 2 KK 9 SSWDSTGLV 5 SYWMN 19 GIENKYAGGATYYAASVKG 6 GFGTDF crystal 2.60A 23.20% FAB 13-AUG-15 20150813 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOR04357, A NEUTRALIZING ANTI - HUMAN GM - CSF ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 11 SGDSIGKKYAY 5 KKRPS 9 SAWGDKGMV 5 SYWMN 19 GIENKYAGGATYYAASVKG 6 GFGTDF crystal 1.88A 21.40% FAB 14-AUG-15 20150814 IMMUNE SYSTEM DEVELOPMENT OF A THERAPEUTIC MONOCLONAL ANTIBODY TARGETING SECRETED AP2 TO TREAT TYPE 2 DIABETES. MOLECULE: FATTY ACID - BINDING PROTEIN, ADIPOCYTE; SYNONYM: 3T3 - L1 LIPID - BINDING PROTEIN,ADIPOCYTE LIPID - BINDING PROTEIN,ALBP,ADIPOCYTE - TYPE FATTY ACID - BINDING PROTEIN,AFABP,FATTY ACID - BINDING PROTEIN 4,MYELIN P2 PROTEIN HOMOLOG,P15,P2 ADIPOCYTE PROTEIN,PROTEIN 422; ENGINEERED: YES; ? ? ORYCTOLAGUS CUNICULUS 12 SVSSSISSSNLH 7 GTSNLAS 9 QQWSHYPLT 5 SNWIT 17 DIYPGSGSTTNNEKFKS 10 LRGYYDYFDF crystal 3.00A 20.80% FAB 17-AUG-15 20150817 OXIDOREDUCTASE OXIDOREDUCTASE FRAGMENT OF MOUSE QSOX1 IN COMPLEX WITH A FAB FRAGMENT FROM A MOUSE QSOX1 - SPECIFIC ANTIBODY MOLECULE: SULFHYDRYL OXIDASE 1; FRAGMENT: RESIDUES 36 - 275; SYNONYM: MSOX,QUIESCIN Q6,SKIN SULFHYDRYL OXIDASE; EC: 1.8.3.2; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYMY 7 RTSNLAS 9 QQYHSYPLT 5 SYYIH 17 WIYPGSYNTEYSEKFKG 7 SEDWFAY crystal 2.20A 17.70% FAB 18-AUG-15 20150818 IMMUNE SYSTEM OXIDOREDUCTASE FRAGMENT OF MOUSE QSOX1 IN COMPLEX WITH A FAB FRAGMENT FROM AN ANTIBODY TARGETING MOUSE AND HUMAN QSOX1 MOLECULE: SULFHYDRYL OXIDASE 1; SYNONYM: MSOX,QUIESCIN Q6,SKIN SULFHYDRYL OXIDASE; EC: 1.8.3.2; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSGAVA 7 MASQRYT 9 QQHYAIPLT 5 GYSVI 16 MIWGDGRTEYKSALKS 10 DSMDPGSFAY crystal 2.30A 17.00% FAB 18-AUG-15 20150818 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BG505 SOSIP GP140 HIV - 1 ENV TRIMER IN COMPLEX WITH THE BROADLY NEUTRALIZING FAB PGT122 AND SCFV NIH45 - 46 MOLECULE: ENVELOPE GLYCOPROTEIN GP41; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS 11 GEESLGSRSVI 7 NNNDRPS 15 YYCHIWDSRRPTNWV 5 DNYWS 16 YVHDSGDTNYNPSLKS 24 TKHGRRIYGVVAFKEWFTYFYMDV crystal 4.40A 29.00% FV 18-AUG-15 20150818 TRANSPORT PROTEIN STRUCTURE OF THE THE SLC26 TRANSPORTER SLC26DG IN COMPLEX WITH A NANOBODY MOLECULE: SULPHATE TRANSPORTER; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 1 G 19 VAAVTRSGGKSYNADSVKG 13 GDTAITSWYGYDY crystal 3.20A 26.10% HC-dimer 19-AUG-15 20150819 IMMUNE SYSTEM STRUCTURE OF A NANOBODY RECOGNIZING THE FUMARATE TRANSPORTER SLC26DG MOLECULE: NANOBODY RECOGNIZING THE MEMBRANE PROTEIN SLC26DG; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SSDVMG 18 VAAVTRSGGKSYNADSVK 14 AGDTAITSWYGYDY crystal 2.40A 23.30% HC-dimer 19-AUG-15 20150819 IMMUNE SYSTEM CRYSTAL STRUCTURES IN AN ANTI - HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES MOLECULE: OLIGO PEPTIDE; ENGINEERED: YES ? ? MACACA MULATTA 11 RTSQSISTWLA 7 TASSLAS 9 QQYISLPPT 5 SFWWG 17 TIYGSSGRGEYNPSLKS 19 GLFQPNGFSFTLTSYWFDV crystal 2.49A 23.20% FAB 24-AUG-15 20150824 IMMUNE SYSTEM CRYSTAL STRUCTURES IN AN ANTI - HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES ? ? ? MACACA MULATTA 11 RTSQSISTWLA 7 TASSLAS 9 QQYISLPPT 5 SFWWG 17 TIYGSSGRGEYNPSLKS 19 GLFQPNGFSFTLTSYWFDV crystal 1.60A 18.70% FAB 24-AUG-15 20150824 IMMUNE SYSTEM CRYSTAL STRUCTURES IN AN ANTI - HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES ? ? ? MACACA MULATTA 11 RTSQTISTWLA 7 TASSLES 9 QQYISLPPT 5 SFWWG 17 TIYGSSGRGEYNPSLKS 19 GLFQPNGFSFTLTSYWFDV crystal 1.80A 20.20% FAB 24-AUG-15 20150824 IMMUNE SYSTEM CRYSTAL STRUCTURES IN AN ANTI - HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES ? ? ? MACACA MULATTA 11 RASQSISTWLA 7 KASSLES 9 QQYSSKPPT 5 SFWWG 17 TIYGSSGRAEYNPSLKS 19 GLFQPNGFSFTLTSYWFDV crystal 1.90A 20.20% FAB 24-AUG-15 20150824 IMMUNE SYSTEM CRYSTAL STRUCTURES IN AN ANTI - HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES ? ? ? MACACA MULATTA 11 RTSQSISTWLA 7 TASSLAS 9 QQYISLPPT 5 SFWWG 17 TIYGSSGRGEYNPSLKS 15 GLFQPATLTSYWFDV crystal 1.70A 19.10% FAB 24-AUG-15 20150824 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH MURINE FAB FRAGMENT K04 MOLECULE: CD81 ANTIGEN; SYNONYM: 26 KDA CELL SURFACE PROTEIN TAPA - 1,TARGET OF THE ANTIPROLIFERATIVE ANTIBODY 1,TETRASPANIN - 28,TSPAN - 28; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASKSVSTSIYSYMH 7 YASYLES 9 EHSREFPFT 5 SSWMN 17 RIYSGDGDAIYNGKFKG 11 EGKTGDLLLRS crystal 2.80A 24.20% FV 27-AUG-15 20150827 CELL ADHESION CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT K13 MOLECULE: CD81 ANTIGEN; FRAGMENT: UNP RESIDUES 112 - 201; SYNONYM: 26 KDA CELL SURFACE PROTEIN TAPA - 1,TARGET OF THE ANTIPROLIFERATIVE ANTIBODY 1,TETRASPANIN - 28,TSPAN - 28; ENGINEERED: YES; ? ? MUS MUSCULUS 17 TTSGFNFKDSYLHWVKQ 7 NGNVKFD 15 YYCVPYGYGFHSWGD 5 DSYLH 17 RIDTGNGNVKFDPKFQD 18 YGYGFHSWGDGTTLTVSS crystal 2.33A 19.40% scFv 27-AUG-15 20150827 TRANSFERASE STRUCTURE OF VPS34 COMPLEX II FROM S. CEREVISIAE. MOLECULE: SERINE / THREONINE - PROTEIN KINASE VPS15; SYNONYM: GOLGI - RETENTION DEFECTIVE MUTANT PROTEIN 8,VACUOLAR PROTEIN SORTING - ASSOCIATED PROTEIN 15; EC: 2.7.11.1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 4 NSMG 16 VMTIDGRTNYQDSVKG 7 ETRGFMH crystal 4.40A 36.90% HC-dimer 27-AUG-15 20150827 IMMUNE SYSTEM HIV - 1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES MOLECULE: PROTEIN REV; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQSISSWLS 7 DASNLAS 12 LGGYPAASYRTA 5 GFWLN 17 AIYRGSGSEWYASWAKG 10 DTTDNGYFTI crystal 2.30A 19.00% FAB 31-AUG-15 20150831 IMMUNE SYSTEM HIV - 1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES MOLECULE: PROTEIN REV; SYNONYM: ART / TRS,ANTI - REPRESSION TRANSACTIVATOR,REGULATOR OF EXPRESSION OF VIRAL PROTEINS; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQSISSWLS 7 DASNLAS 12 LGGYPAASYRTA 3 SWL 19 IYDASNLASGVPSRFMGSG 26 TAFGGGTELEIIQEQLVESGGRLVTP crystal 2.90A 24.70% scFv 31-AUG-15 20150831 IMMUNE SYSTEM HIV - 1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES MOLECULE: PROTEIN REV; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQSISSWLS 7 DASNLAS 12 LGGYPAASYRTA 5 GFWLN 17 AIYRGSGSEWYASWAKG 10 DTTDNGYFTI crystal 3.10A 29.20% FAB 31-AUG-15 20150831 IMMUNE SYSTEM HIV - 1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES MOLECULE: PROTEIN REV; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQSISSWLS 7 DASNLAS 12 LGGYPAASYRTA 5 GFWLN 17 AIYRGSGSEWYASWAKG 10 DTTDNGYFTI crystal 4.30A 0.00% FAB 31-AUG-15 20150831 IMMUNE SYSTEM FC KNOB - HOLE HETERODIMER T366W + T366S / L368A / Y407V ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 22.70% FC 31-AUG-15 20150831 IMMUNE SYSTEM FC HETERODIMER DESIGN 11.2 Y349S / K370Y + E357D / S364Q ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.28A 19.60% FC 01-SEP-15 20150901 IMMUNE SYSTEM FC HETERODIMER DESIGN 7.4 Y407A + T366V / K409V ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.56A 19.00% FC 01-SEP-15 20150901 IMMUNE SYSTEM FC HETERODIMER DESIGN 6.1 F405W / Y407A + T366M ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.00A 23.70% FC 01-SEP-15 20150901 IMMUNE SYSTEM FC HETERODIMER DESIGN 7.7 D399M / Y407A + T366V / K409I ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 21.70% FC 01-SEP-15 20150901 IMMUNE SYSTEM FC HETERODIMER DESIGN 9.1 Y407M + T366I ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.90A 21.00% FC 01-SEP-15 20150901 IMMUNE SYSTEM FC HETERODIMER DESIGN 8.1 L368V / Y407A + T366V / K409F ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.10A 23.20% FC 01-SEP-15 20150901 IMMUNE SYSTEM FC HETERODIMER DESIGN 5.1 T366V + Y407F ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 22.30% FC 02-SEP-15 20150902 IMMUNE SYSTEM FC HETERODIMER DESIGN 2.9 L368M / K370E + E357A / S364G ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.25A 20.60% FC 02-SEP-15 20150902 IMMUNE SYSTEM FC HETERODIMER DESIGN 20.8 Y349S / T366V / K370Y / K409V + E357D / S364Q / Y407A ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.15A 22.30% FC 02-SEP-15 20150902 IMMUNE SYSTEM FC HETERODIMER DESIGN 7.8 D399M / Y407A + T366V / K409V ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 23.40% FC 02-SEP-15 20150902 IMMUNE SYSTEM FC HETERODIMER DESIGN 20.8.34 Y349S / T366M / K370Y / K409V + E356G / E357D / S364Q / Y407A ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 22.70% FC 02-SEP-15 20150902 IMMUNE SYSTEM FC HETERODIMER E356K / D399K + K392D / K409D ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630; OTHER_DETAILS: CPC SCIENTIFIC INC., SUNNYVALE CA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 22.80% FC 02-SEP-15 20150902 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PEMBROLIZUMAB, A FULL LENGTH IGG4 ANTIBODY MOLECULE: LIGHT CHAIN; ENGINEERED: YES; ? IGG4 HOMO SAPIENS 15 RASKGVSTSGYSYLH 7 LASYLES 9 QHSRDLPLT 5 NYYMY 17 GINPSNGGTNFNEKFKN 11 RDYRFDMGFDY crystal 2.28A 18.60% ? 02-SEP-15 20150902 IMMUNE SYSTEM COMPLEX OF INFLUENZA M2E AND ANTIBODY MOLECULE: MATRIX PROTEIN 2; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 16 RSSQSIVHSIGDTYLE 7 KVSNRFS 9 FQGSHFPYT 5 TYAMS 16 SMSSGGSLYYPDTVKG 7 GGYGTSY crystal 2.20A 18.90% ? 07-SEP-15 20150907 IMMUNE SYSTEM X - RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416 - 430) MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 12 QSSQSVRTNKLA 7 SASTLDF 13 LGYFDCSIADCVA 0 N/A 0 N/A 0 N/A crystal 2.50A 21.20% LC-dimer 08-SEP-15 20150908 IMMUNE SYSTEM / SIGNALING PROTEIN STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH CHI220 FAB MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5; FRAGMENT: EXTRACELLULAR DOMAIN RESIDUES 23 - 193; SYNONYM: B - CELL SURFACE ANTIGEN CD40,BP50,CD40L RECEPTOR,CDW40; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSISDYLH 7 YASHSIS 9 QHGHSFPWT 5 TTGMQ 17 WINTHSGVPKYVEDFKG 13 SGNGNYDLAYFAY crystal 3.69A 17.00% FAB 08-SEP-15 20150908 IMMUNE SYSTEM / SIGNALING PROTEIN STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56 - 5 DAB ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD40, TNFRSF5; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: HB2151; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PDOM13 0 0 0 0 0 0 crystal 2.79A 23.00% DAB 08-SEP-15 20150908 VIRAL PROTEIN / IMMUNE SYSTEM COMPLEX STRUCTURE OF MERS - RBD BOUND WITH 4C2 ANTIBODY MOLECULE: S PROTEIN; FRAGMENT: UNP RESIDUES 367 - 606; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPRT 5 SYTMS 17 TISSGGSYTYYPDSVKG 7 DGNDYDY crystal 2.41A 24.70% ? 10-SEP-15 20150910 IMMUNE SYSTEM STRUCTURE OF S55 - 3 FAB IN COMPLEX WITH LIPID A MOLECULE: MAB 44B1 LIGHT CHAIN; ? ? MUS MUSCULUS 15 RASETVDSYGNSFMH 7 RASNLES 9 QQSNEDPRT 5 GYGMS 17 LISNGGSYAYYSDSVKG 13 HKGLRGGTNAMDY crystal 1.95A 21.40% FAB 14-SEP-15 20150914 IMMUNE SYSTEM STRUCTURE OF S55 - 5 FAB IN COMPLEX WITH LIPID A CARBOHYDRATE BACKBONE WITH LIPID A CARBOHYDRATE BACKBONE KAPPA ? MUS MUSCULUS 15 RASESVDNYGNSFMH 7 RASNLES 9 QQSNEDPRT 5 SHGMS 17 LISRGGSYTYYSDSVKG 13 HKGLRRGTNAMDY crystal 1.94A 17.50% FAB 14-SEP-15 20150914 IMMUNE SYSTEM STRUCTURE OF UNLIGANDED S55 - 5 FAB ? KAPPA ? MUS MUSCULUS 15 RASESVDNYGNSFMH 7 RASNLES 9 QQSNEDPRT 5 SHGMS 17 LISRGGSYTYYSDSVKG 13 HKGLRRGTNAMDY crystal 2.61A 19.50% FAB 14-SEP-15 20150914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SCLEROSTIN - NEUTRALIZING FAB ABD09097 ? ? ? HOMO SAPIENS 12 RASQSISSNELA 7 DTSNRAT 9 QQYYSYPIT 5 NYYMH 17 TIAYDGSSTYYADSVKG 6 WFTDDI crystal 1.85A 19.10% FAB 15-SEP-15 20150915 IMMUNE SYSTEM CONTEXT - INDEPENDENT ANTI - HYPUSINE ANTIBODY FABHPU24 IN COMPLEX WITH HYPUSINE WITH HYPUSINE ? ? ORYCTOLAGUS CUNICULUS 13 QSSETVYRGDWLS 7 DASYLAS 11 LGGYYDDADDT 5 DYAMI 17 IIYGGSNKLAYAKWAKG 13 GYGSMDGYDRLNL crystal 1.99A 18.50% FAB 16-SEP-15 20150916 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BCR FAB FRAGMENT FROM SUBSET #4 CASE CLL183 ? ? ? HOMO SAPIENS 16 CRSSQSLVHSDGNTYL 7 YKVSDRD 11 CMQGTHWPPYT 5 GYYWT 16 EINHSGSTTYNPSLKS 18 GYGDTPTIRRYYYYGMDV crystal 2.27A 19.70% FAB 16-SEP-15 20150916 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BCR FAB FRAGMENT FROM SUBSET #4 CASE CLL240 MOLECULE: CLL240 HEAVY CHAIN (VH AND CH1 DOMAINS); ENGINEERED: YES; ? ? HOMO SAPIENS 16 CRSSQSLVHSDGNTYL 7 YKVSDRD 11 CMQGTHWPPYT 5 GYYWS 16 EINHSGSTNYNPSLKS 18 GYADTPVFRRYYYYGMDV crystal 2.10A 19.50% FAB 16-SEP-15 20150916 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 ANTIBODY F240 FAB IN COMPLEX WITH GP41 PEPTIDE MOLECULE: ENVELOPE GLYCOPROTEIN GP160; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 17 RSSRNILHSLNNKNYLA 7 WASMRVS 9 QHYYTTHRT 5 DYYMS 17 YITKDGSEKKYADSLQH 16 DDGYYDRSGYYGVFDL crystal 2.54A 20.60% FAB 16-SEP-15 20150916 IMMUNE SYSTEM CONTEXT - INDEPENDENT ANTI - HYPUSINE ANTIBODY FABHPU98 IN COMPLEX WITH HYPUSINE MOLECULE: TETRAPEPTIDE GLY - HPU - GLY - ALA; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 11 QASEDIKRYLA 7 AASKLAS 12 QQGYTSSNVNNA 0 N/A 0 N/A 0 N/A crystal 1.95A 18.50% FAB 17-SEP-15 20150917 IMMUNE SYSTEM CONTEXT - INDEPENDENT ANTI - HYPUSINE ANTIBODY FABHPU24.B IN COMPLEX WITH HYPUSINE MOLECULE: PEPTIDE: GLY - HPU - GLY - SER - GLY; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 13 RSRQRVYLGDWLS 7 DASFRGD 11 LGGYYDDADDT 5 DYAMI 17 IIYGVINDLAYAKWAKG 13 GYGSMDGYDRLNL crystal 2.40A 20.90% FAB 17-SEP-15 20150917 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB CAP256 - VRC26.25, A POTENT V1V2 - DIRECTED HIV - 1 BROADLY NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 13 SGNTSNIGNNFVS 7 ETDKRPS 12 ATWAASLSSARV 5 GYGMH 19 SISHDGIKKYHAEKVWGRF 26 DLREDECEEWWSDDFGKQLPCAKSRG crystal 1.95A 17.20% FAB 17-SEP-15 20150917 IMMUNE SYSTEM CONTEXT - INDEPENDENT ANTI - HYPUSINE ANTIBODY FABHPU98.61 IN COMPLEX WITH HYPUSINE MOLECULE: PEPTIDE: GLY - 5CT - GLY - ALA; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 11 QASEDIKRYLA 7 AASKLAS 12 QQGYTSSNVNNA 0 N/A 0 N/A 0 N/A crystal 1.90A 21.30% FAB 18-SEP-15 20150918 IMMUNE SYSTEM CONTEXT - INDEPENDENT ANTI - HYPUSINE ANTIBODY FABHPU98 IN COMPLEX WITH DEOXYHYPUSINE MOLECULE: PEPTIDE: GLY - 5GG - GLY - ALA; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 11 QASEDIKRYLA 7 AASKLAS 12 QQGYTSSNVNNA 0 N/A 0 N/A 0 N/A crystal 2.00A 18.30% FAB 18-SEP-15 20150918 IMMUNE SYSTEM CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY 65C6 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSNLA 7 GASTRAT 9 QQYNNWPYT 7 STYFWIS 17 RIDPTDSYINYSPSFQG 18 HRRGHFYGSGSAWDWFES crystal 3.00A 21.80% FAB 19-SEP-15 20150919 IMMUNE SYSTEM INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH ANTIBODY AVFLUIGG03 MOLECULE: HEMAGGLUTININ; FRAGMENT: GLOBULAR HEAD, UNP RESIDUES 61 - 284; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GNSNRPS 9 QSYDSSVVV 5 NYAMS 13 AISGTYYADSVKG 18 DDSYDGGGHYGLHNWFDS crystal 3.05A 20.70% ? 20-SEP-15 20150920 IMMUNE SYSTEM INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH ANTIBODY 100F4 MOLECULE: HEMAGGLUTININ; FRAGMENT: GLOBULAR HEAD, UNP RESIDUES 61 - 284; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGGSSNIGAGYSVH 7 GSNSRPS 12 QSYDSSLSGSQV 7 SGSYYWS 16 NMHGSGHTNYNPSLKS 11 ALLTTVTTFEY crystal 2.82A 21.00% ? 20-SEP-15 20150920 IMMUNE SYSTEM FC DESIGN 7.7 B CHAIN HOMODIMER T366V / K409I ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 23.70% FC 21-SEP-15 20150921 IMMUNE SYSTEM FC DESIGN 20.8.37 A CHAIN HOMODIMER Y349S / T366M / K370Y / K409V ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 20.20% FC 21-SEP-15 20150921 IMMUNE SYSTEM FC DESIGN 20.8.37 B CHAIN HOMODIMER E357D / S364R / Y407A ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.95A 22.60% FC 21-SEP-15 20150921 IMMUNE SYSTEM FC K392D / K409D HOMODIMER ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 18.90% FC 21-SEP-15 20150921 IMMUNE SYSTEM FC K392D / K409D HOMODIMER ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 19.40% FC 21-SEP-15 20150921 IMMUNE SYSTEM BETA COMMON RECEPTOR IN COMPLEX WITH A FAB MOLECULE: CYTOKINE RECEPTOR COMMON SUBUNIT BETA; SYNONYM: CDW131,GM - CSF / IL - 3 / IL - 5 RECEPTOR COMMON BETA SUBUNIT; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQGISSWLA 7 AASSLQS 9 QQANSFPIT 5 WYRVH 17 SIRSSGGFPYYNYKVKG 8 FYDSFFDI crystal 3.97A 29.10% FAB 23-SEP-15 20150923 SIGNALING PROTEIN CRYSTAL STRUCTURE OF MOUSE PD - L1 NANOBODY ? ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 5 MHAMT 17 VITSHGDRANYTDSVRG 5 PRYDS crystal 1.44A 17.00% HC-dimer 24-SEP-15 20150924 IMMUNE SYSTEM FAB43.1 COMPLEX WITH FLOURESCEIN WITH FLOURESCEIN ? ? MUS MUSCULUS 16 KSSQSLFASDGRTYLN 7 LVSNLDS 9 WQGTHFPQT 5 TSVIH 17 YIFPYNYGTQYNEEFRG 4 RSGP crystal 2.36A 19.60% FAB 25-SEP-15 20150925 SIGNALING PROTEIN CRYSTAL STRUCTURE OF MOUSE CTLA - 4 NANOBODY ? ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 5 SVAVG 17 TSSTSSTTATYADSVKG 4 GLTN crystal 1.69A 17.20% HC-dimer 28-SEP-15 20150928 IMMUNE SYSTEM / RNA SPECIFIC RECOGNITION OF A SINGLE - STRANDED RNA SEQUENCE BY AN ENGINEERED SYNTHETIC ANTIBODY FRAGMENT MOLECULE: RNA; ENGINEERED: YES ? ? HOMO SAPIENS 11 CRASQSVSSAV 7 YSASSLY 10 CQQSYSYPYT 5 SSYIH 17 YIYPYYGSTYYADSVKG 17 YYSSGGSYYRYSRGFDY crystal 2.38A 21.10% FAB 28-SEP-15 20150928 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF THE NUP98 C - TERMINAL DOMAIN BOUND TO NANOBODY TP377 MOLECULE: NUCLEAR PORE COMPLEX PROTEIN NUP98 - NUP96; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: C - TERMINAL DOMAIN, RESIDUES 715 - 866 ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 NSVMA 19 LSVLNWSSGRTSIADSVKG 17 SNRGSLYTLDNQNRYED crystal 1.90A 16.90% HC-dimer 29-SEP-15 20150929 METAL TRANSPORT STRUCTURE OF KCSA WITH L24C / R117C MUTATIONS MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 4 - 124; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 3.40A 24.80% FAB 29-SEP-15 20150929 TOXIN / IMMUNE SYSTEM RICIN TOXIN IN COMPLEX WITH NEUTRALIZING SINGLE CHAIN MONOCLONAL ANTIBODIES (VHHS) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: RICINUS COMMUNIS; ORGANISM_COMMON: CASTOR BEAN; ORGANISM_TAXID: 3988; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: CAMELIDAE; ORGANISM_TAXID: 9835; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.03A 20.50% VHH 29-SEP-15 20150929 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - TAU ANTIBODY AT8 FAB MOLECULE: AT8 LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPYT 6 SGYYWN 16 YISYDGSNNYNPSLKN 4 GSLV crystal 2.10A 20.80% FAB 01-OCT-15 20151001 IMMUNE SYSTEM STRUCTURE OF ANTI - TAU AT8 FAB IN THE PRESENCE OF PHOSPHOPEPTIDE MOLECULE: AT8 LIGHT CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSKSLLHGNTYLY 0 9 MQHLEYPYT 6 SGYYWN 16 YISYDGSNNYNPSLKN 4 GSLV crystal 2.40A 18.90% FAB 01-OCT-15 20151001 IMMUNE SYSTEM ANTI - TAU AT8 FAB WITH DOUBLY PHOSPHORYLATED TAU PEPTIDE MOLECULE: TAU PHOSPHOPEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPYT 6 SGYYWN 16 YISYDGSNNYNPSLKN 4 GSLV crystal 1.64A 16.60% FAB 01-OCT-15 20151001 IMMUNE SYSTEM ANTI - TAU AT8 FAB WITH TRIPLY PHOSPHORYLATED TAU PEPTIDE MOLECULE: TAU - PHOSPHOPEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPYT 6 SGYYWN 16 YISYDGSNNYNPSLKN 4 GSLV crystal 1.50A 21.60% FAB 01-OCT-15 20151001 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOUSE CTLA - 4 IN COMPLEX WITH NANOBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: CTLA4, CD152; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.18A 19.50% Nanobody 08-OCT-15 20151008 IMMUNE SYSTEM STRUCTURE OF A NANOBODY (VHH) FROM CAMEL AGAINST PHAGE TP901 - 1 RBP (BPPL, ORF53) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: DROMEDARY; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21; EXPRESSION_SYSTEM_TAXID: 511693; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN6 0 0 0 0 0 0 crystal 1.10A 16.00% Nanobody 12-OCT-15 20151012 VIRAL PROTEIN COMPLEX BETWEEN LACTOCOCCAL PHAGE TUC2009 RBP HEAD DOMAIN AND A NANOBODY (L06) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: DROMEDARY; ORGANISM_TAXID: 9838; STRAIN: BL21; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21; EXPRESSION_SYSTEM_TAXID: 511693; MOL_ID: 2; ORGANISM_SCIENTIFIC: LACTOCOCCUS PHAGE TUC2009; ORGANISM_TAXID: 35241; EXPRESSION_SYSTEM: LACTOCOCCUS LACTIS; EXPRESSION_SYSTEM_TAXID: 1358 0 0 0 0 0 0 crystal 2.70A 19.50% Nanobody 12-OCT-15 20151012 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN EPIREGULIN IN COMPLEX WITH THE FAB FRAGMENT OF MURINE MONOCLONAL ANTIBODY 9E5 MOLECULE: PROEPIREGULIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDINKYIA 7 YTSTLHP 8 LQYDNLRT 5 DTYMH 17 RIDPLNDKTKYDPKFQG 9 GGGDPVFVY crystal 2.50A 19.30% FAB 14-OCT-15 20151014 IMMUNE SYSTEM / HYDROLASE CRYSTAL STRUCTURE OF THROMBIN BOUND TO AN EXOSITE 1 - SPECIFIC IGA FAB MOLECULE: THROMBIN HEAVY CHAIN; SYNONYM: COAGULATION FACTOR II; EC: 3.4.21.5; ? IGA HOMO SAPIENS 11 RASQNVSSFLA 7 DASSRAT 10 QQRRSWPPLT 5 EAAIH 17 GLDPQDGETVYAQQFKG 16 GDFSEFEPFSMDYFHF crystal 1.90A 20.30% FAB 14-OCT-15 20151014 MEMBRANE PROTEIN ANTIBODY - BOUND GLUCAGON - LIKE PEPTIDE - 1 RECEPTOR EXTRACELLULAR DOMAIN MOLECULE: GLUCAGON - LIKE PEPTIDE 1 RECEPTOR; FRAGMENT: N - TERMINAL EXTRACELLULAR DOMAIN, UNP RESIDUES 24 - 145; SYNONYM: GLP - 1R; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPFT 6 STYDWH 16 YISYSGSTNYNPSLKS 14 ATASFYDGSYYFDY crystal 2.00A 19.00% FAB 14-OCT-15 20151014 IMMUNE SYSTEM BOVINE FAB FRAGMENT F08_B11 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTGGTAGYNPGLKT 26 VYQKTTQKKNCPDDYTECYGGACDGT crystal 2.06A 19.80% FAB 14-OCT-15 20151014 IMMUNE SYSTEM STRUCTURE OF THE ANTIBODY 7968 WITH HUMAN COMPLEMENT FACTOR H - DERIVED PEPTIDE MOLECULE: COMPLEMENT FACTOR H - RELATED PROTEIN 2; FRAGMENT: UNP RESIDUES 150 - 162; SYNONYM: FHR - 2,DDESK59,H FACTOR - LIKE 3,H FACTOR - LIKE PROTEIN 2; ENGINEERED: YES; OTHER_DETAILS: THE PEPTIDE WAS N - TERMINALLY ACETYLATED AND C - TERMINALLY AMIDATED. ? ? HOMO SAPIENS 17 KSSQRLLYSSNNKNYLA 7 WASTRES 9 QQYYNPPWT 5 RYGMH 17 VMSYDGSTKYYADSVKG 10 GGAAAAVMDV crystal 2.00A 20.20% FAB 15-OCT-15 20151015 MEMBRANE PROTEIN KCSA T75G IN THE CONDUCTIVE STATE MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 1 - 125; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.30A 20.90% FAB 19-OCT-15 20151019 MEMBRANE PROTEIN KCSA T75G MUTANT IN THE NONCONDUCTIVE STATE MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 1 - 125; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.50A 21.90% FAB 19-OCT-15 20151019 MEMBRANE PROTEIN KCSA WITH G77ESTER MUTATION MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 1 - 123; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.30A 22.50% FAB 19-OCT-15 20151019 MEMBRANE PROTEIN KCSA WITH V76ESTER MUTATION MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 1 - 125; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.75A 24.60% FAB 20-OCT-15 20151020 MEMBRANE PROTEIN KCSA WITH V76ESTER+G77DA MUTATIONS MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 1 - 125; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.30A 23.30% FAB 20-OCT-15 20151020 IMMUNE SYSTEM STRUCTURAL DETERMINATION OF AN PROTEIN COMPLEX OF A FAB WITH INCREASED SOLUBILITY MOLECULE: HISTONE CHAPERONE ASF1; FRAGMENT: UNP RESIDUES 1 - 156; SYNONYM: ANTI - SILENCING FUNCTION PROTEIN 1,YASF1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSDDPIT 5 YSSIH 17 SISSYYGSTYYADSVKG 15 SRGQASWDYWWAMDY crystal 2.44A 18.80% FAB 29-OCT-15 20151029 VIRAL PROTEIN / IMMUNE SYSTEM MOLECULAR BASIS FOR ANTIBODY - MEDIATED NEUTRALIZATION OF NEW WORLD HEMORRHAGIC FEVER MAMMARENAVIRUSES MOLECULE: PRE - GLYCOPROTEIN POLYPROTEIN GP COMPLEX; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQNVGSAVA 7 SASNRYT 9 QQYSSYPLA 5 NYWMQ 17 AVYPGDGDTRFSQKFKG 15 RRVYYGSNYIYALDY crystal 1.82A 18.30% ? 09-NOV-15 20151109 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB C2 IN COMPLEX WITH A CYCLIC VARIANT OF HEPATITIS C VIRUS E2 EPITOPE I MOLECULE: ALA - CYS - GLN - LEU - ILE - ASN - THR - ASN - GLY - SER - TRP - HIS - ILE - CYS; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASKSVSTSGYSYMH 7 LGSNLES 9 QHIRELTRS 5 TYWMN 17 MIQPSDSETRLNQKFKD 10 TGRGDAWLTY crystal 1.98A 23.40% FAB 10-NOV-15 20151110 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF THE MURINE FAB 1G6 BOUND TO THE VACCINIA VIRUS A27 PEPTIDE 31 - 40 MOLECULE: PROTEIN A27; FRAGMENT: UNP RESIDUES 31 - 40; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPPT 7 TSGMGVG 16 HIWWDDDKYYNPSLQS 9 DRGYYAMDY crystal 1.95A 19.90% FAB 10-NOV-15 20151110 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF THE MURINE ANTIBODY FAB 8E3 BOUND TO THE VACCINIA VIRUS A27 PEPTIDE 101 - 110 MOLECULE: PROTEIN A27; FRAGMENT: UNP RESIDUES 101 - 110; ENGINEERED: YES ? ? MUS MUSCULUS 12 TLSSQHSTYTID 7 LRRDGSH 15 IYICGVGDTIKEQFV 5 SYGVH 16 VIWSGGNTDYNAAFIS 7 YYRYGAY crystal 2.27A 20.40% FAB 10-NOV-15 20151110 TOXIN / IMMUNE SYSTEM CERATOTOXIN VARIANT IN COMPLEX WITH SPECIFIC ANTIBODY FAB FRAGMENT MOLECULE: BETA - THERAPHOTOXIN - CM1A; SYNONYM: BETA - TRTX - CM1A,CCOTX1,CERATOTOXIN - 1; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVHNNGNTYIE 7 KVSNRFS 9 FQGSHVPFT 5 NFWMN 17 MIDPSDSETHYNQMFKD 10 RDYYGILFDY crystal 1.75A 19.20% FAB 11-NOV-15 20151111 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF HCV E2 GLYCOPROTEIN ANTIGENIC EPITOPE II BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC84 - 26 MOLECULE: HCV E2 GLYCOPROTEIN EPITOPE II; ENGINEERED: YES ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 9 QVWDSSSVV 6 SNYVIT 17 GGFIPTFRTAMYAQGFQ 11 RGPLSRGYYDY crystal 2.90A 22.00% FAB 15-NOV-15 20151115 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HCV E2 ANTIBODY HC84 - 26 ? ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 9 QVWDSSSVV 5 NYVIT 17 GFIPTFRTAMYAQGFQG 10 GPLSRGYYDY crystal 2.60A 18.80% FAB 16-NOV-15 20151116 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH CYCLIC BETA - ALANINE - LINKED MEDITOPE MOLECULE: CYCLIC BETA - ALANINE - LINKED MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.55A 19.20% FAB 16-NOV-15 20151116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CH03, ISOLATED FROM DONOR CH0219, IN COMPLEX WITH SCAFFOLDED TRIMERIC HIV - 1 ENV V1V2 DOMAIN FROM THE CLADE C SUPERINFECTING STRAIN OF DONOR CAP256. MOLECULE: 2 - C - METHYL - D - ERYTHRITOL 2,4 - CYCLODIPHOSPHATE SYNTHASE, ENVELOPE GLYCOPROTEIN GP160; SYNONYM: MECPS,ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 13 - 1 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 18 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 19 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 21 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 25 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 6 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 7 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 8 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 9 ENV POLYPROTEIN,ENVELOPE GLYCOPROTEIN GP160,MECPS; EC: 4.6.1.12,4.6.1.12; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVHPKYFA 7 SGSTRAA 9 QQYGGSPYT 5 NYGLT 17 GMNWNGGDTRYADSVRG 24 GTDYTIDDQGIFYKGSGTFWYFDL crystal 3.11A 21.10% ? 17-NOV-15 20151117 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CH04, ISOLATED FROM DONOR CH0219, IN COMPLEX WITH SCAFFOLDED TRIMERIC HIV - 1 ENV V1V2 DOMAIN FROM THE CLADE AE STRAIN A244 MOLECULE: 2 - C - METHYL - D - ERYTHRITOL 2,4 - CYCLODIPHOSPHATE SYNTHASE, ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 125 - 205; SYNONYM: MECPS,ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 13 - 1 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 18 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 19 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 21 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 25 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 6 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 7 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 8 ENV POLYPROTEIN,ENVELOPE GLYCOPROTEIN GP160,MECPS; EC: 4.6.1.12,4.6.1.12; ENGINEERED: YES ? ? HOMO SAPIENS 9 RASSSRYFA 7 GGSTRAT 9 QQYGRSPYT 5 NFGFG 17 GTNWNGGDSRYGDSVKG 24 GTDYTIDDQGIRYQGSGTFWYFDV crystal 4.19A 25.50% ? 17-NOV-15 20151117 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH L5E MEDITOPE VARIANT MOLECULE: L5E MEDITOPE VARIANT; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.53A 18.30% FAB 18-NOV-15 20151118 VIRAL PROTEIN CRYSTAL STRUCTURE OF HIV - 1 INTEGRASE CATALYTIC CORE IN COMPLEX WITH FAB MOLECULE: INTEGRASE; FRAGMENT: CATALYTIC CORE DOMAIN, UNP RESIDUES 36 - 188; SYNONYM: PR160GAG - POL; EC: 2.7.7. -; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: INTEGRASE CENTRAL CORE DOMAIN; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSYSPLT 5 SYSMH 17 YIYPYSGSTSYADSVKG 21 ESSYFYDGSYSYYDYEGAMDY crystal 2.64A 18.40% FAB 18-NOV-15 20151118 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH F3H MEDITOPE VARIANT MOLECULE: F3H MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.50A 17.50% FAB 18-NOV-15 20151118 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN FAB VRC38.01, AN HIV - 1 V1V2 - DIRECTED NEUTRALIZING ANTIBODY ISOLATED FROM DONOR N90 MOLECULE: VRC38.01 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLLLGNGRNYLD 7 LGSNRAS 10 MEARQTPRLT 5 DNDMH 16 SIGSSGDTYYIDAVKG 16 GPESGWFYHYYWGLGV crystal 1.60A 17.40% FAB 20-NOV-15 20151120 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB OF PARASITE INVASION INHIBITORY ANTIBODY C1 - HEXAGONAL FORM ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A N/A N/A FAB 26-NOV-15 20151126 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB OF PARASITE INVASION INHIBITORY ANTIBODY C1 - ORTHORHOMBIC FORM ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: MOUSE; EXPRESSION_SYSTEM_TAXID: 10090 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A N/A N/A FAB 26-NOV-15 20151126 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB OF PARASITE INVASION INHIBITORY ANTIBODY C1 - MONOCLINIC FORM ? ? ? MUS MUSCULUS 11 KASQSVRNDVA 7 FASNRYT 9 QQGYTSPRT 5 RYWMS 17 EINPGSSTIKYTPSLKD 10 YGSYVYAMDY crystal 2.43A 19.00% FAB 26-NOV-15 20151126 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFCYRPA IN COMPLEX WITH AN INVASION - INHIBITORY ANTIBODY FAB. MOLECULE: C12 FAB; ENGINEERED: YES ? ? HOMO SAPIENS 11 KASQSVRNDVA 7 FASNRYT 9 QQGYTSPRT 5 RYWMS 17 EINPGSSTIKYTPSLKD 10 YGSYVYAMDY crystal 3.63A 27.60% FAB 26-NOV-15 20151126 HYDROLASE / IMMUNE SYSTEM HUMAN CD38 IN COMPLEX WITH NANOBODY MU1053 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD38; EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS; EXPRESSION_SYSTEM_COMMON: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: X33; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPICZALPHA; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN2 0 0 0 0 0 0 crystal 2.30A 20.00% Nanobody 30-NOV-15 20151130 HYDROLASE / IMMUNE SYSTEM HUMAN CD38 IN COMPLEX WITH NANOBODY MU551 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD38; EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS; EXPRESSION_SYSTEM_COMMON: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: X33; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPICZALPHA; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN2 0 0 0 0 0 0 crystal 2.20A 17.10% Nanobody 30-NOV-15 20151130 HYDROLASE / IMMUNE SYSTEM HUMAN CD38 IN COMPLEX WITH NANOBODY MU375 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD38; EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS; EXPRESSION_SYSTEM_COMMON: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: X33; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPICZALPHA; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN2 0 0 0 0 0 0 crystal 1.90A 16.50% Nanobody 01-DEC-15 20151201 SIGNALING PROTEIN / IMMUNE SYSTEM STRUCTURE OF MYOSTATIN IN COMPLEX WITH CHIMERIC RK35 ANTIBODY MOLECULE: GROWTH / DIFFERENTIATION FACTOR 8; FRAGMENT: UNP RESIDUES 267 - 375; SYNONYM: GDF - 8,MYOSTATIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSTPWT 5 SYAMS 17 TISSGGSYTSYPDSVKG 7 QDYAMNY crystal 1.76A 18.10% ? 02-DEC-15 20151202 SIGNALING PROTEIN / IMMUNE SYSTEM STRUCTURE OF MYOSTATIN IN COMPLEX WITH HUMANIZED RK35 ANTIBODY MOLECULE: GROWTH / DIFFERENTIATION FACTOR 8; SYNONYM: GDF - 8,MYOSTATIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSTPWT 5 SYAMS 17 TISSGGSYTSYPDSVKG 7 QDYAMNY crystal 2.70A 22.10% ? 02-DEC-15 20151202 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DBP IN COMPLEX WITH INHIBITORY MONOCLONAL ANTIBODY 2D10 MOLECULE: DUFFY RECEPTOR; FRAGMENT: UNP RESIDUES 211 - 525; SYNONYM: ERYTHROCYTE - BINDING PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSKSLLYQDGKTYLN 7 LMSTRAS 15 QQLVEYPLTFGAGTK 7 YQDGKTY 13 QLLIYLMSTRASG 26 QQLVEYPLTFGAGTKLELKRQLQQSG crystal 4.00A 26.90% scFv 02-DEC-15 20151202 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TIER 2 NEUTRALIZING ANTIBODY DH427 FROM A RHESUS MACAQUE ? ? ? HOMO SAPIENS 14 TGTSSDIGAYTGVS 7 DVSKRPS 10 CSYRTGATYI 5 NSGMI 17 YISLSGANTYYADSVKG 8 EGWSYFDF crystal 2.66A 23.20% FAB 06-DEC-15 20151206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TIER 2 NEUTRALIZING ANTIBODY DH428 FROM A RHESUS MACAQUE ? ? ? HOMO SAPIENS 14 TGTNSDIGDYNGVS 7 DVSKRPS 10 CSYRTGGTYI 5 TYGMS 17 YISISGGSTYYTDSVKG 8 EGWAYFDY crystal 2.32A 22.00% FAB 06-DEC-15 20151206 VIRAL PROTEIN / IMMUE SYSTEM CRYSTAL STRUCTURE OF TIER 2 NEUTRALIZING ANTIBODY DH427 FROM A RHESUS MACAQUE IN COMPLEX WITH HIV - 1 GP120 CORE MOLECULE: ENVELOPE GLYCOPROTEIN GP120 OF HIV - 1 CLADE C; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGTSSDIGAYTGVS 7 DVSKRPS 10 CSYRTGATYI 5 NSGMI 17 YISLSGANTYYADSVKG 8 EGWSYFDF crystal 6.63A 25.90% FAB 06-DEC-15 20151206 DE NOVO PROTEIN DE NOVO DESIGN AND CRYSTALLOGRAPHIC VALIDATION OF ANTIBODIES TARGETING A PRE - SELECTED EPITOPE MOLECULE: KELCH - LIKE ECH - ASSOCIATED PROTEIN 1; SYNONYM: CYTOSOLIC INHIBITOR OF NRF2,INRF2,KELCH - LIKE PROTEIN 19; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.85A 22.50% scFv 07-DEC-15 20151207 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GERM - LINE PRECURSOR OF 3BNC60 FAB ? ? ? HOMO SAPIENS 11 QASQDISNYLN 7 DASNLET 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 10 ERSDFWDFDL crystal 1.90A 20.00% FAB 08-DEC-15 20151208 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN 17875 IN COMPLEX WITH NANOBODY NB - ER19 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; VARIANT: 17875; GENE: BABA2; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: WK6 0 0 0 0 0 0 crystal 2.17A 17.30% Nanobody 08-DEC-15 20151208 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN 17875 IN COMPLEX WITH NANOBODY NB - ER14 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; VARIANT: 17875; GENE: BABA2; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: WK6 0 0 0 0 0 0 crystal 2.74A 21.50% Nanobody 08-DEC-15 20151208 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN 17875 IN COMPLEX WITH BLOOD GROUP H LEWIS B HEXASACCHARIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; VARIANT: 17875; GENE: BABA2; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10 0 0 0 0 0 0 crystal 2.72A 18.10% Nanobody 08-DEC-15 20151208 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN 17875 IN COMPLEX WITH BLOOD GROUP A LEWIS B PENTASACCHARIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; VARIANT: 17875; GENE: BABA2; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; VARIANT: 17875; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10 0 0 0 0 0 0 crystal 2.28A 17.20% Nanobody 08-DEC-15 20151208 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN 17875 IN COMPLEX WITH BLOOD GROUP B LEWIS B HEPTASACCHARIDE MOLECULE: ADHESIN BINDING FUCOSYLATED HISTO - BLOOD GROUP ANTIGEN; SYNONYM: BLOOD GROUP ANTIGEN BINDING ADHESIN (BABA); ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 GNVMG 16 AITPQGVPNYADSVKG 6 LPNYRS crystal 2.81A 17.30% HC-dimer 08-DEC-15 20151208 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN 17875 IN COMPLEX WITH BLOOD GROUP A TYPE - 1 HEXASACCHARIDE MOLECULE: ADHESIN BINDING FUCOSYLATED HISTO - BLOOD GROUP ANTIGEN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 GNVMG 16 AITPQGVPNYADSVKG 6 LPNYRS crystal 2.44A 17.70% HC-dimer 08-DEC-15 20151208 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH L5Y MEDITOPE VARIANT MOLECULE: L5Y MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 16.50% FAB 09-DEC-15 20151209 IMMUNE SYSTEM STRUCTURE OF THE UNLIGANDED FAB FROM HIV - 1 NEUTRALISING ANTIBODY CAP248 - 2B THAT BINDS TO THE GP120 C - TERMINUS - GP41 INTERFACE MOLECULE: CAP248 - 2B HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDIGGYKYVS 7 DVIKRPS 15 SSYTTKKTSFFGPAT 7 NEDYYWT 17 DIYYNSGTTHYNPSLKS 15 EASTKITDDGGAFDF crystal 2.78A 23.10% FAB 09-DEC-15 20151209 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN S831 IN COMPLEX WITH NANOBODY NB - ER19 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; GENE: BABA2, BABA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: WK6 0 0 0 0 0 0 crystal 2.59A 19.70% Nanobody 09-DEC-15 20151209 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN S831 IN COMPLEX WITH BLOOD GROUP H LEWIS B HEXASACCHARIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; GENE: BABA2, BABA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: WK6 0 0 0 0 0 0 crystal 2.44A 19.10% Nanobody 09-DEC-15 20151209 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN A730 IN COMPLEX WITH BLOOD GROUP H LEWIS B HEXASACCHARIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; GENE: BABA2, BABA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.99A 18.40% Nanobody 09-DEC-15 20151209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VH1 - 46 GERMLINE - DERIVED CD4 - BINDING SITE - DIRECTED ANTIBODY CH235.12 IN COMPLEX WITH HIV - 1 CLADE A / E 93TH057 GP120 MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASRSVRNNVA 7 DASTRAA 8 LQYNNWWT 5 DYYIH 17 YIDPANGRPDYAGALRE 13 NVGTAGSLLHYDH crystal 2.24A 19.20% ? 09-DEC-15 20151209 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN A730 IN COMPLEX WITH BLOOD GROUP A TYPE 1 HEXASACCHARIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; GENE: BABA2, BABA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: WK6 0 0 0 0 0 0 crystal 2.62A 19.10% Nanobody 09-DEC-15 20151209 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN P436 IN COMPLEX WITH BLOOD GROUP H LEWIS B HEXASACCHARIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; GENE: BABA2, BABA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: WK6 0 0 0 0 0 0 crystal 2.44A 20.70% Nanobody 09-DEC-15 20151209 CELL ADHESION BLOOD GROUP ANTIGEN BINDING ADHESIN BABA OF HELICOBACTER PYLORI STRAIN P436 IN COMPLEX WITH LEWIS B BLOOD GROUP B HEPTASACCHARIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HELICOBACTER PYLORI; ORGANISM_TAXID: 210; GENE: BABA2, BABA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: TOP10; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_VARIANT: WK6 0 0 0 0 0 0 crystal 2.59A 19.70% Nanobody 09-DEC-15 20151209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VH1 - 46 GERMLINE - DERIVED CD4 - BINDING SITE - DIRECTED ANTIBODY CH235.09 IN COMPLEX WITH HIV - 1 CLADE A / E 93TH057 GP120 MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVRNNLA 7 GASTRAT 8 QQYNNWWT 5 DYYIH 17 WIDPSGGRTDYAGAFGD 13 NVGTAGSLLHYDH crystal 1.86A 20.50% ? 10-DEC-15 20151210 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VH1 - 46 GERMLINE - DERIVED CD4 - BINDING SITE - DIRECTED ANTIBODY CH235 IN COMPLEX WITH HIV - 1 CLADE A / E 93TH057 GP120 MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVRSNLA 7 GTSTRAT 8 LQYNNWWT 5 NYYVH 17 WIDPSWGRTNYAQNFQG 13 NVATEGSLLHYDY crystal 2.89A 18.30% ? 10-DEC-15 20151210 IMMUNE SYSTEM STRUCTURE OF INTERLEUKIN - 16 BOUND TO THE 14.1 ANTIBODY MOLECULE: PRO - INTERLEUKIN - 16; FRAGMENT: UNP RESIDUES 1224 - 1323; ENGINEERED: YES KAPPA ? MUS MUSCULUS 15 RASKSVSTSGYSYMH 7 LASNLES 9 QHSRELPYT 5 GYTMN 17 LINPYNSGTNYNQKFKD 12 SDYYDSTHYFDY crystal 2.07A 17.40% FAB 14-DEC-15 20151214 IMMUNE SYSTEM DIABODY MOLECULE: DIABODY; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.01A 17.80% scFv 15-DEC-15 20151215 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE INNER DOMAIN OF CLADE A / E HIV - 1 GP120 IN COMPLEX WITH THE ADCC - POTENT RHESUS MACAQUE ANTIBODY JR4 MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; FRAGMENT: UNP RESIDUES 1 - 140; ENGINEERED: YES; ? ? MACACA MULATTA 13 SGSSSNIGRSYVS 7 DTNKRPS 11 GAWDGSLNVHI 5 RNYWS 17 HSYGSGGSTNYNPSLES 14 TVWYYTSGTHYFDH crystal 1.85A 18.60% FAB 15-DEC-15 20151215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 3BNC60 FAB GERMLINE PRECURSOR IN COMPLEX WITH 426C.TM4DELTAV1 - 3 GP120 MOLECULE: 426C.TM4DELTAV1 - 3 GP120; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 QASQDISNYLN 7 DASNLET 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 10 ERSDFWDFDL crystal 3.17A 20.40% FAB 16-DEC-15 20151216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PCT64_35B, A BROADLY NEUTRALIZING ANTI - HIV ANTIBODY ? ? ? HOMO SAPIENS 12 RATQRVGSDYLA 7 GTSRRAA 8 RQYETSFS 0 13 LEWVGHYAAPVKG 4 LIDV crystal 3.10A 26.00% FAB 17-DEC-15 20151217 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH L10Q MEDITOPE VARIANT MOLECULE: L10Q MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.50A 15.80% FAB 17-DEC-15 20151217 IMMUNE SYSTEM THREE DIMENSIONAL STRUCTURE OF BROADLY NEUTRALIZING HUMAN ANTI - HEPATITIS C VIRUS (HCV) GLYCOPROTEIN E2 FAB FRAGMENT HC33.4 MOLECULE: GENOME POLYPROTEIN; EC: 3.4.22. - ,3.4.21.98,3.6.1.15,3.6.4.13,2.7.7.48; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDNLGDKFVC 7 EDTKRPS 10 QTWDSSTDVV 5 SYAMS 17 AISGSGGSTYYADSVKG 12 AVVFYYSKYFDY crystal 1.65A 17.20% FAB 20-DEC-15 20151220 VIRAL PROTEIN THREE DIMENSIONAL STRUCTURE OF BROADLY NEUTRALIZING HUMAN ANTI - HEPATITIS C VIRUS (HCV) GLYCOPROTEIN E2 FAB FRAGMENT HC33.8 MOLECULE: GENOME POLYPROTEIN; EC: 3.4.22. - ,3.4.21.98,3.6.1.15,3.6.4.13,2.7.7.48; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDKLGDKYVS 7 QDNKRPS 10 QAWDSSTDVV 5 TYAMT 17 ASSSTDGTTYYADSVKG 18 AVVFTDSSAYYYSKYFDY crystal 1.90A 19.60% FAB 20-DEC-15 20151220 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PROTECTIVE EBOLA VIRUS ANTIBODY 114 ? ? ? HOMO SAPIENS 11 RASQAFDNYVA 7 AASALHA 9 QNYNSAPLT 5 MYDMH 16 AVGPSGDTYYADSVKG 11 SDRGVAGLFDS crystal 1.97A 18.20% FAB 21-DEC-15 20151221 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PROTECTIVE EBOLA VIRUS ANTIBODY 100 ? ? ? HOMO SAPIENS 11 SGDNLGDKYVC 7 QDNKRPS 8 QTWDSTVV 5 SFYWS 16 YIYYSGSPNYSPSLES 17 ASRSYYWGSYRPTAFDS crystal 1.97A 16.00% FAB 21-DEC-15 20151221 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF PROTECTIVE HUMAN ANTIBODIES 100 AND 114 IN COMPLEX WITH EBOLA VIRUS FUSION GLYCOPROTEIN (GP) MOLECULE: ENVELOPE GLYCOPROTEIN; FRAGMENT: UNP RESIDUES 502 - 599; SYNONYM: GP1,2,GP; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNLGDKYVC 7 QDNKRPS 8 QTWDSTVV 5 MYDMH 16 AVGPSGDTYYADSVKG 11 SDRGVAGLFDS crystal 6.70A 26.50% FAB 21-DEC-15 20151221 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 ANG. RESOLUTION. MOLECULE: INTERLEUKIN - 4; SYNONYM: IL - 4,B - CELL STIMULATORY FACTOR 1,BSF - 1,BINETRAKIN,LYMPHOCYTE STIMULATORY FACTOR 1,PITRAKINRA; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.55A 18.70% ? 22-DEC-15 20151222 VIRUS ELECTRON CRYO - MICROSCOPY OF GRAPEVINE FANLEAF VIRUS COMPLEX WITH NANOBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: GRAPEVINE FANLEAF VIRUS; ORGANISM_TAXID: 12274; MOL_ID: 2; ORGANISM_SCIENTIFIC: GRAPEVINE FANLEAF VIRUS; ORGANISM_TAXID: 12274 0 0 0 0 0 0 ElectronMicroscopy N/A N/A Nanobody 22-NOV-15 20151122 IMMUNE SYSTEM BIOPHYSICAL AND CELLULAR CHARACTERISATION OF A JUNCTIONAL EPITOPE ANTIBODY THAT LOCKS IL - 6 AND GP80 TOGETHER IN A STABLE COMPLEX: IMPLICATIONS FOR NEW THERAPEUTIC STRATEGIES MOLECULE: INTERLEUKIN - 6; FRAGMENT: RESIDUES 49 - 212; SYNONYM: IL - 6, B - CELL STIMULATORY FACTOR 2, BSF - 2, IFN - BETA - 2, CTL DIFFERENTIATION FACTOR, CDF, HYBRIDOMA GROWTH FACTOR, INTERFERON BETA - 2; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 TYCMG 17 HIYTNSGRTYYADSVKG 16 RPSIRCASFSATEYKD crystal 2.70A 23.10% HC-dimer 25-JAN-16 20160125 IMMUNE SYSTEM EXTENDING THE HALF - LIFE OF A FAB FRAGMENT THROUGH GENERATION OF A HUMANISED ANTI - HUMAN SERUM ALBUMIN (HSA) FV DOMAIN: AN INVESTIGATION INTO THE CORRELATION BETWEEN AFFINITY AND SERUM HALF - LIFE MOLECULE: SERUM ALBUMIN; SYNONYM: FAB645 - HSA; ENGINEERED: YES; ? ? HOMO SAPIENS 12 QSSPSVWSNFLS 7 EASKLTS 11 GGGYSSISDTT 5 NYAIN 16 IIWASGTTFYATWAKG 13 TVPGYSTAPYFDL crystal 3.60A 21.51% FAB 28-JAN-16 20160128 VIRAL PROTEIN ECTODOMAIN OF CLEAVED WILD TYPE JR - FL ENVDCT TRIMER IN COMPLEX WITH PGT151 FAB MOLECULE: HIV - 1 ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41, RESIDUES 503 - 655; ENGINEERED: YES; OTHER_DETAILS: GP41 ECTODOMAIN OF JR - FL ENV; ? ? HOMO SAPIENS 16 KSSESLRQSNGKTSLY 7 EVSNRFS 9 MQSKDFPLT 5 KYPMY 17 AISGDAWHVVYSNSVQG 26 MFQESGPPRLDRWSGRNYYYYSGMDV ElectronMicroscopy N/A N/A FAB 29-JAN-16 20160129 IMMUNE SYSTEM EXTENDING THE HALF - LIFE OF A FAB FRAGMENT THROUGH GENERATION OF A HUMANISED ANTI - HUMAN SERUM ALBUMIN (HSA) FV DOMAIN: AN INVESTIGATION INTO THE CORRELATION BETWEEN AFFINITY AND SERUM HALF - LIFE ? ? ? HOMO SAPIENS 12 QSSPSVWSNFLS 7 EASKLTS 11 GGGYSSISDTT 5 NYAIN 16 IIWASGTTFYATWAKG 13 TVPGYSTAPYFDL crystal 2.68A 21.19% FAB 01-FEB-16 20160201 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HVEGF IN COMPLEX WITH VK DOMAIN ANTIBODY MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; FRAGMENT: VEGF RESIDUES 27 - 136; SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF, VASCULAR ENDOTHE LIAL GROWTH FACTOR; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQWIGPELK 7 HGSILQS 9 QQYMYYPHT 0 N/A 0 N/A 0 N/A crystal 2.70A 20.82% LC-dimer 02-FEB-16 20160202 HORMONE CRYSTAL STRUCTURE OF HVEGF IN COMPLEX WITH VH DOMAIN ANTIBODY MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; FRAGMENT: VEGF UNP RESIDUES 27 - 136; SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF, VASCULAR ENDOTHELIAL GROWTH FACTOR; ENGINEERED: YES; ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 AYPMM 17 EISPSGSYTYYADSVKG 7 DPRKLDY crystal 3.45A 21.48% HC-dimer 02-FEB-16 20160202 IMMUNE SYSTEM LLAMA NANOBODY PORM_130 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYVMG 17 AISWSGGSIHYADSVKG 21 GFAGYGSFTSRSARDSDKYDY crystal 1.70A 18.80% HC-dimer 18-FEB-16 20160218 VIRAL PROTEIN CRYSTAL STRUCTURE AT 3.4 A RESOLUTION OF FULLY GLYCOSYLATED HIV - 1 CLADE G X1193.C1 SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES PGT122, 35O22 AND VRC01 MOLECULE: GP41 ENV ECTODOMAIN; FRAGMENT: GP41 ENV ECTODOMAIN, RESIDUES 510 - 663; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.11A 21.66% FAB 08-MAR-16 20160308 VIRAL PROTEIN CRYSTAL STRUCTURE AT 3.7 A RESOLUTION OF FULLY GLYCOSYLATED HIV - 1 CLADE JR - FL SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES PGT122, 35O22 AND VRC01 MOLECULE: JR - FL, GP41 ENV ECTODOMAIN; FRAGMENT: GP41 ENV ECTODOMAIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.11A 24.88% FAB 08-MAR-16 20160308 VIRAL PROTEIN CRYSTAL STRUCTURE AT 3.7 A RESOLUTION OF FULLY GLYCOSYLATED HIV - 1 CLADE A BG505 SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES PGT122 AND 35O22 MOLECULE: BG505 GP120 ENV ECTODOMAIN; FRAGMENT: GP120 ENV ECTODOMAIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.10A 25.37% FAB 08-MAR-16 20160308 HYDROLASE CBS DOMAIN TANDEM OF SITE - 2 PROTEASE FROM ARCHAEOGLOBUS FULGIDUS IN COMPLEX WITH LLAMA NANOBODY - APO FORM MOLECULE: SITE - 2 PROTEASE; FRAGMENT: REGULATORY DOMAIN, RESIDUES 236 - 362; EC: 3.4.24.85; ENGINEERED: YES; OTHER_DETAILS: C - TERMINAL STREPII - TAG; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NNAMG 16 AITSFGSTNYADSVKG 9 GWGATPRSY crystal 2.40A 20.90% HC-dimer 02-JUN-16 20160602 HYDROLASE CBS DOMAIN TANDEM OF SITE - 2 PROTEASE FROM ARCHAEOGLOBUS FULGIDUS IN COMPLEX WITH LLAMA NANOBODY - NUCLEOTIDE - BOUND FORM MOLECULE: SITE - 2 PROTEASE; FRAGMENT: REGULATORY DOMAIN, RESIDUES 236 - 362; EC: 3.4.24.85; ENGINEERED: YES; OTHER_DETAILS: C - TERMINAL STREPII - TAG; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NNAMG 16 AITSFGSTNYADSVKG 9 GWGATPRSY crystal 2.80A 24.80% HC-dimer 09-JUN-16 20160609 IMMUNE SYSTEM THE COMPLEX BETWEEN HUMAN IGE - FC AND TWO ANTI - IGE FAB FRAGMENTS MOLECULE: IG EPSILON CHAIN C REGION; FRAGMENT: IMMUNOGLOBULIN E - FC; SYNONYM: IMMUNOGLOBULIN E; ENGINEERED: YES; MUTATION: YES; ? IGE HOMO SAPIENS 15 RASQSVDYDGDSYMN 7 AASYLES 9 QQSHEDPYT 6 SGYSWN 16 SITYDGSTNYNPSVKG 12 GSHYFGHWHFAV crystal 3.72A 26.10% FAB 14-JUN-16 20160614 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NIVOLUMAB FAB FRAGMENT MOLECULE: NIVOLUMAB LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQSSNWPRT 5 NSGMH 17 VIWYDGSKRYYADSVKG 4 NDDY crystal 1.90A 19.70% FAB 16-JUN-16 20160616 IMMUNE SYSTEM PD - 1 IN COMPLEX WITH NIVOLUMAB FAB MOLECULE: PROGRAMMED CELL DEATH PROTEIN 1; FRAGMENT: UNP RESIDUES 26 - 150; SYNONYM: HPD - 1; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQSSNWPRT 5 NSGMH 17 VIWYDGSKRYYADSVKG 4 NDDY crystal 3.30A 22.40% FAB 16-JUN-16 20160616 IMMUNE SYSTEM PD - 1 IN COMPLEX WITH PEMBROLIZUMAB FAB MOLECULE: PROGRAMMED CELL DEATH PROTEIN 1; FRAGMENT: UNP RESIDUES 26 - 148; SYNONYM: HPD - 1; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 15 RASKGVSTSGYSYLH 7 LASYLES 9 QHSRDLPLT 5 NYYMY 17 GINPSNGGTNFNEKFKN 11 RDYRFDMGFDY crystal 2.00A 18.20% FAB 16-JUN-16 20160616 IMMUNE SYSTEM PD - L1 IN COMPLEX WITH BMS - 936559 FAB MOLECULE: PROGRAMMED CELL DEATH 1 LIGAND 1; FRAGMENT: UNP RESIDUES 18 - 134; SYNONYM: PROGRAMMED DEATH LIGAND 1,B7 HOMOLOG 1,B7 - H1; ENGINEERED: YES; MUTATION: YES; ? IGG HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 8 QQRSNWPT 5 TYAIS 17 GIIPIFGKAHYAQKFQG 14 KFHFVSGSPFGMDV crystal 2.80A 21.40% FAB 16-JUN-16 20160616 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TREMELIMUMAB FAB MOLECULE: HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSINSYLD 7 AASSLQS 9 QQYYSTPFT 5 SYGMH 17 VIWYDGSNKYYADSVKG 16 DPRGATLYYYYYGMDV crystal 2.29A 18.80% FAB 16-JUN-16 20160616 IMMUNE SYSTEM CTLA - 4 IN COMPLEX WITH TREMELIMUMAB FAB MOLECULE: LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 17 EYASPGKATEVRVTVLR 7 MGNELTF 13 KVELMYPPPYYLG 5 SYGMH 17 VIWYDGSNKYYADSVKG 16 DPRGATLYYYYYGMDV crystal 2.00A 18.30% FAB 16-JUN-16 20160616 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROAD NEUTRALIZING ANTIBODY 10E8 WITH LONG EPITOPE BOUND MOLECULE: ENDOGENOUS RETROVIRUS GROUP K MEMBER 8 ENV POLYPROTEIN; FRAGMENT: UNP RESIDUES 674 - 698; SYNONYM: ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 13 - 1 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 18 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 19 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 21 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 25 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 6 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 7 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 9 ENV POLYPROTEIN,ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.40A 19.40% FAB 21-JUN-16 20160621 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FAB FRAGMENT WITH ITS LIGAND PEPTIDE MOLECULE: LYS - PRO - ILE - ILE - ILE - GLY - SER - HIS - ALA - TYR - GLY - ASP; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQRISNNLH 7 YTSQSIS 9 QQSNSWPFT 5 SYWMN 17 MIHPSDGETRLNQKFKD 4 HFDY crystal 1.93A 18.40% FAB 24-JUN-16 20160624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FAB FRAGMENT WITH ITS LIGAND PEPTIDE MOLECULE: THR - LYS - PRO - ILE - THR - ILE - GLY - SER - HIS - ALA - HIS - GLY - ASP - GLN - TYR - LYS; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQRISNNLH 7 YTSQSIS 9 QQSNSWPFT 5 SYWMN 17 MIHPSDGETRLNQKFKD 4 HFDY crystal 1.93A 18.80% FAB 24-JUN-16 20160624 IMMUNE SYSTEM CRYSTAL STRUCTURE OF H1 HEMAGGLUTININ FROM A / CALIFORNIA / 04 / 2009 IN COMPLEX WITH A NEUTRALIZING ANTIBODY 3E1 MOLECULE: HEMAGGLUTININ; FRAGMENT: NEUTRALIZING ANTIBODY 3E1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASSLES 9 QQYNSYPWT 5 SYYWI 16 RFYTSGSPNYNPSLRS 13 EEHITFGGVIVRY crystal 2.90A 25.40% FAB 01-JUL-16 20160701 IMMUNE SYSTEM CRYSTAL STRUCTURE OF H1 HEMAGGLUTININ FROM A / WASHINGTON / 05 / 2011 IN COMPLEX WITH A NEUTRALIZING ANTIBODY 3E1 MOLECULE: HEMAGGLUTININ; FRAGMENT: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASSLES 9 QQYNSYPWT 5 SYYWI 16 RFYTSGSPNYNPSLRS 13 EEHITFGGVIVRY crystal 3.10A 21.80% FAB 01-JUL-16 20160701 IMMUNE SYSTEM / DNA CRYSTAL STRUCTURE OF SLE PATIENT - DERIVED ANTI - DNA ANTIBODY IN COMPLEX WITH OLIGONUCLEOTIDE MOLECULE: DNA (5' - D (P *TP *TP *TP *T) - 3'); ENGINEERED: YES LAMBDA IGG2 HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 DVSKRPS 10 CSYAGSYTYV 2 WS 16 YIYYSGSTNYNPSLKS 8 HRNWLFDY crystal 2.10A 16.40% FAB 05-JUL-16 20160705 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SLE PATIENT - DERIVED ANTI - DNA ANTIBODY ? LAMBDA IGG2 HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 DVSKRPS 10 CSYAGSYTYV 5 SYFWS 16 YIYYSGSTNYNPSLKS 8 HRNWLFDY crystal 2.05A 21.90% FAB 05-JUL-16 20160705 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF MERS - COV RBD IN COMPLEX WITH A FULLY HUMAN ANTIBODY MCA1 MOLECULE: S PROTEIN; FRAGMENT: UNP RESIDUES 367 - 588; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPIT 5 SYAIS 17 RIIPILGIANYAQKFQG 15 KQGDYYDRTSYAFDI crystal 2.70A 24.10% ? 15-JUL-16 20160715 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN PD - L1 WITH MONOCLONAL ANTIBODY AVELUMAB MOLECULE: AVELUMAB H CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 DVSNRPS 10 SSYTSSSTRV 5 SYIMM 17 SIYPSGGITFYADTVKG 11 IKLGTVTTVDY crystal 3.21A 20.50% ? 11-AUG-16 20160811 IMMUNE SYSTEM STRUCTURE OF MONO - SPECIFIC DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; ORGANISM_TAXID: 83333; STRAIN: K12; GENE: MALE, B4034, JW3994; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 3; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111 0 0 0 0 0 0 crystal 1.96A 19.90% Diabody 12-AUG-16 20160812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HOMO - SPECIFIC DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111 0 0 0 0 0 0 crystal 2.30A 18.50% Diabody 12-AUG-16 20160812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HOMO - SPECIFIC DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111 0 0 0 0 0 0 crystal 2.80A 18.20% Diabody 12-AUG-16 20160812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DISULFIDE - BONDED DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.00A 17.00% Diabody 12-AUG-16 20160812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DISULFIDE - BONDED DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.64A 19.90% Diabody 12-AUG-16 20160812 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DISULFIDE - BONDED DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.70A 24.90% Diabody 13-AUG-16 20160813 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX OF TLR3 AND BI - SPECIFIC DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: TLR3; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 3; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 4; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 5; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111 0 0 0 0 0 0 crystal 3.28A 19.50% Diabody 13-AUG-16 20160813 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HOMO - SPECIFIC DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111 0 0 0 0 0 0 crystal 2.00A 26.70% Diabody 13-AUG-16 20160813 SUGAR BINDING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DIABODY COMPLEX WITH REPEBODY AND MBP ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ESCHERICHIA COLI (STRAIN K12); ORGANISM_TAXID: 83333; STRAIN: K12; GENE: MALE, B4034, JW3994; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 4; ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; ORGANISM_TAXID: 562; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 3.59A 22.20% Diabody 13-AUG-16 20160813 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DIABODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_TAXID: 7111 0 0 0 0 0 0 crystal 1.70A 19.30% Diabody 13-AUG-16 20160813 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IGG FC WITH A HOMOGENEOUS GLYCOFORM AND ANTIBODY - DEPENDENT CELLULAR CYTOTOXICITY ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: OVARY CELL; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.85A 22.90% FC 17-AUG-16 20160817 MEMBRANE PROTEIN CYTOCHROME C - DEPENDENT NITRIC OXIDE REDUCTASE (CNOR) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH XENON MOLECULE: NITRIC OXIDE REDUCTASE SUBUNIT B; FRAGMENT: NITRIC OXIDE REDUCTASE SUBUNIT B; SYNONYM: NOR LARGE SUBUNIT,NITRIC OXIDE REDUCTASE CYTOCHROME B SUBUNIT; EC: 1.7.2.5; ? ? MUS MUSCULUS 11 RASKSIRKYLA 7 SGSTLQF 9 QQHNEYPLT 5 SYWMH 17 AVYPGNSDTSYNQKFKG 15 SSLDGYYVKNWCFDV crystal 3.30A 21.20% FAB 31-AUG-16 20160831 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF A LACY / NANOBODY COMPLEX ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ESCHERICHIA COLI (STRAIN K12); ORGANISM_TAXID: 83333; STRAIN: K12; GENE: LACY, B0343, JW0334; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 3.30A 34.00% Nanobody 16-SEP-16 20160916 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FM329, A RECOMBINANT FAB ADOPTED FROM CETUXIMAB MOLECULE: FM329 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS/MUS MUSCULUS XENOGRAFT 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 1.70A 18.90% FAB 26-SEP-16 20160926 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN MOLECULE: GENOME POLYPROTEIN; FRAGMENT: ENVELOPE PROTEIN, UNP RESIDUES 291 - 699; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DSNKRPS 11 GTWDSSLSVWV 5 SYAMH 17 VISYDGSNKYYADSVKG 18 DHLGWSSIWSAPESFLDY crystal 3.00A 22.40% ? 29-SEP-16 20160929 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN MOLECULE: GENOME POLYPROTEIN; FRAGMENT: ENVELOPE PROTEIN, UNP RESIDUES 291 - 699; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGIRNDLG 7 AASSLQS 9 LQHNSYPRT 6 SSNWWS 16 EIYHSGSTNYNPSLKS 10 DRDDLSPFDY crystal 2.76A 23.30% ? 29-SEP-16 20160929 VIRUS ZIKA VIRUS E PROTEIN COMPLEXED WITH A NEUTRALIZING ANTIBODY Z23 - FAB MOLECULE: STRUCTURAL PROTEIN E; ? IGG HOMO SAPIENS 11 RASQSVISNLA 7 GASTRAT 8 QQYNNWWT 5 GYYMH 17 RINPNSGGTNYAQKFEG 12 TGIAAAGFVFDY ElectronMicroscopy N/A N/A FAB 01-OCT-16 20161001 IMMUNE SYSTEM STRUCTURE OF A NOVEL ANTIBODY G196 MOLECULE: G196 ANITIBODY HEAVY CHAIN; ? ? MUS MUSCULUS 11 KASENVVTYVS 7 GASNRYT 9 GQGYSYPYT 5 NYWMH 17 EINPSNGGSNYNEKFKR 7 WDSYFDY crystal 2.00A 21.50% ? 14-OCT-16 20161014 VIRUS / IMMUNE SYSTEM CRYO - EM STRUCTURE OF ZIKA VIRUS COMPLEXED WITH FAB C10 AT PH 6.5 MOLECULE: STRUCTURAL PROTEIN E; ? IGG HOMO SAPIENS 14 TGTSSDVGGFNYVS 7 DVTSRPS 10 SSHTSRGTWV 5 SYAMH 17 WINAGNGNTKYSQKFQD 19 DKVDDYGDYWFPTLWYFDY ElectronMicroscopy N/A N/A FAB 19-OCT-16 20161019 VIRUS / IMMUNE SYSTEM CRYO - EM STRUCTURE OF ZIKA VIRUS COMPLEXED WITH FAB C10 AT PH 5.0 MOLECULE: STRUCTURAL PROTEIN E; ? IGG HOMO SAPIENS 14 TGTSSDVGGFNYVS 7 DVTSRPS 10 SSHTSRGTWV 5 SYAMH 17 WINAGNGNTKYSQKFQD 19 DKVDDYGDYWFPTLWYFDY ElectronMicroscopy N/A N/A FAB 20-OCT-16 20161020 IMMUNE SYSTEM / MEMBRANE PROTEIN CRYSTAL STRUCTURES OF THE TRIC TRIMERIC INTRACELLULAR CATION CHANNEL ORTHOLOGUE FROM SULFOLOBUS SOLFATARICUS MOLECULE: MEMBRANE PROTEIN TRIC; FRAGMENT: UNP RESIDUES 1 - 198; SYNONYM: UNCHARACTERIZED PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQFIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPWT 5 IYDMS 17 YMSSGRGNTYYPDTVKG 11 GAFYYGYGFAY crystal 2.64A 21.30% FAB 20-OCT-16 20161020 VIRUS / IMMUNE SYSTEM CRYO - EM STRUCTURE OF ZIKA VIRUS COMPLEXED WITH FAB C10 AT PH 8.0 MOLECULE: STRUCTURAL PROTEIN E; ? IGG HOMO SAPIENS 14 TGTSSDVGGFNYVS 7 DVTSRPS 10 SSHTSRGTWV 5 SYAMH 17 WINAGNGNTKYSQKFQD 19 DKVDDYGDYWFPTLWYFDY ElectronMicroscopy N/A N/A FAB 20-OCT-16 20161020 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ASC BINDING NANOBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.89A 17.20% Nanobody 23-DEC-15 20151223 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ASC - BINDING NANOBODY IN COMPLEX WITH THE CARD DOMAIN OF ASC ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: PYCARD, ASC, CARD5, TMS1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 4.21A 30.30% Nanobody 23-DEC-15 20151223 TRANSPORT PROTEIN / TOXIN COMPLEX STRUCTURE OF FAB35 AND HUMAN NACHR ALPHA1 MOLECULE: ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA 1; FRAGMENT: UNP RESIDUES 21 - 231; SYNONYM: CHOLINERGIC RECEPTOR,NICOTINIC,ALPHA 1 (MUSCLE) ,ISOFORM CRA_C; ENGINEERED: YES; MUTATION: YES; ? ? RATTUS NORVEGICUS 11 KGSQNIDNYLA 7 KTNSLQT 8 YQYINGYT 5 SYSVS 16 RMWDDGGTVYNSGLKS 12 DERIRAINWFAY crystal 2.61A 21.00% FAB 02-JAN-16 20160102 TRANSPORT PROTEIN / TOXIN COMPLEX STRUCTURE OF FAB35 AND MOUSE NACHR ALPHA1 MOLECULE: ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA 1; FRAGMENT: UNP RESIDUES 22 - 231; ENGINEERED: YES; MUTATION: YES; ? ? RATTUS NORVEGICUS 11 KGSQNIDNYLA 7 KTNSLQT 8 YQYINGYT 5 SYSVS 16 RMWDDGGTVYNSGLKS 12 DERIRAINWFAY crystal 2.70A 22.90% FAB 02-JAN-16 20160102 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF DISULFIDE CROSS - LINKED D417C CLC - EC1 MOLECULE: H (+) / CL ( - ) EXCHANGE TRANSPORTER CLCA; SYNONYM: CLC - EC1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLTS 9 QQWSSHPQT 5 RYWMS 17 EINPVSSTINYTPSLKD 12 LYYGYGYWYFDV crystal 3.15A 20.80% FAB 05-JAN-16 20160105 MEMBRANE PROTEIN / IMMUNE SYSTEM INTEGRIN ALPHAIIBBETA3 IN COMPLEX WITH RO - 435054 MOLECULE: INTEGRIN BETA - 3; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA,GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 HASQGISSNIG 7 YGTNLVD 9 VQYAQLPYT 5 DTYVH 17 RIDPANGYTKYDPKFQG 10 PLYDYYAMDY crystal 2.70A 21.20% ? 05-JAN-16 20160105 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A NANOBODY RAISED AGAINST UROKINASE - TYPE PLASMINOGEN ACTIVATOR ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: DROMEDARY; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.16A 17.90% Nanobody 05-JAN-16 20160105 TRANSPORT PROTEIN / IMMUNE SYSTEM MNTC CO - STRUCTURE WITH MAB 305 - 78 - 7 MOLECULE: ABC TRANSPORTER SUBSTRATE - BINDING PROTEIN; SYNONYM: MANGANESE ABC TRANSPORTER SUBSTRATE - BINDING PROTEIN, MN2+ / ZN2+ ABC TRANSPORTER PERIPLASMIC PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLYSSNEKNYLA 7 WASTRES 9 QQYYSYPYT 5 RYTMH 17 YINPSSDYTKYNQKFKD 11 KEDVGYWYFDF crystal 1.83A 20.90% FAB 05-JAN-16 20160105 HYDROLASE / INHIBITOR CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH A CAMELID - DERIVED ANTIBODY FRAGMENT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: PLAU; EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS CBS 7435; EXPRESSION_SYSTEM_TAXID: 981350; MOL_ID: 2; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.97A 16.90% VHH 08-JAN-16 20160108 IMMUNE SYSTEM / INHIBITOR INHIBITING COMPLEX IL - 17A AND IL - 17RA INTERACTIONS WITH A LINEAR PEPTIDE MOLECULE: INTERLEUKIN - 17A; FRAGMENT: UNP RESIDUES 34 - 155; SYNONYM: IL - 17A,CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8,CTLA - 8; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.20A 20.00% FAB 11-JAN-16 20160111 IMMUNE SYSTEM / INHIBITOR INHIBITING COMPLEX IL - 17A AND IL - 17RA INTERACTIONS WITH A LINEAR PEPTIDE MOLECULE: INTERLEUKIN - 17A; FRAGMENT: UNP RESIDUES 20 - 155; SYNONYM: IL - 17A,CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8,CTLA - 8; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSLANYYVQ 7 ANNQRPS 11 YCQTYDPYSVV 5 SYAMS 17 AISGSGGSTYYADSVKG 9 DLIHGVTRN crystal 3.00A 18.00% FAB 11-JAN-16 20160111 IMMUNE SYSTEM / INHIBITOR BINDING SITE ELUCIDATION AND STRUCTURE GUIDED DESIGN OF MACROCYCLIC IL - 17A ANTAGONISTS MOLECULE: INTERLEUKIN - 17A; FRAGMENT: UNP RESIDUES 24 - 155; SYNONYM: IL - 17A,CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8,CTLA - 8; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSLANYYVQ 7 ANNQRPS 11 YCQTYDPYSVV 5 SYAMS 17 AISGSGGSTYYADSVKG 9 DLIHGVTRN crystal 2.15A 19.90% FAB 11-JAN-16 20160111 IMMUNE SYSTEM / INHIBITOR BINDING SITE ELUCIDATION AND STRUCTURE GUIDED DESIGN OF MACROCYCLIC IL - 17A ANTAGONISTS MOLECULE: INTERLEUKIN - 17A; FRAGMENT: UNP RESIDUES 24 - 155; SYNONYM: IL - 17A,CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8,CTLA - 8; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSLANYYVQ 7 ANNQRPS 11 YCQTYDPYSVV 5 SYAMS 17 AISGSGGSTYYADSVKG 9 DLIHGVTRN crystal 1.80A 20.10% FAB 11-JAN-16 20160111 IMMUNE SYSTEM / INHIBITOR BINDING SITE ELUCIDATION AND STRUCTURE GUIDED DESIGN OF MACROCYCLIC IL - 17A ANTAGONISTS MOLECULE: INTERLEUKIN - 17A; FRAGMENT: UNP RESIDUES 24 - 155; SYNONYM: IL - 17A,CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8,CTLA - 8; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSLANYYVQ 7 ANNQRPS 11 YCQTYDPYSVV 5 SYAMS 17 AISGSGGSTYYADSVKG 9 DLIHGVTRN crystal 1.80A 20.20% FAB 11-JAN-16 20160111 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HOST - PRIMED EBOLA VIRUS GP, GPCL. MOLECULE: ENVELOPE GLYCOPROTEIN; FRAGMENT: UNP RESIDUES 32 - 194; SYNONYM: GP1,2,GP; ENGINEERED: YES; ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKSYLA 7 WASTRES 9 QQYYSAPLT 5 NYRMN 17 SISSSSSYIHYADSVKG 16 EGPRATGYSMADVFDI crystal 3.30A 22.80% ? 12-JAN-16 20160112 IMMUNE SYSTEM LLAMA VHH 2E7 IN COMPLEX WITH GP41 MOLECULE: GP41; SYNONYM: ENVELOPE GLYCOPROTEIN GP160,ENV POLYPROTEIN; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IDAAG 16 TILTGGATNYADSVKG 12 PMIYYGGRYSDY crystal 2.96A 19.70% HC-dimer 15-JAN-16 20160115 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH CYCLIC LINKED MEDITOPE MOLECULE: CYCLIC AMIDATED, ACETYLATED LINKED MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.67A 19.00% FAB 20-JAN-16 20160120 IMMUNE SYSTEM 1.52 ANGSTROM CRYSTAL STRUCTURE OF FC FRAGMENT OF HUMAN IGG1. ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3)/PMAGIC; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PMCSG28 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.52A 15.90% FC 25-JAN-16 20160125 HYDROLASE / HYDROLASE INHIBITOR CRYSTAL STRUCTURE OF THROMBIN - ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH - I83) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CPB2; EXPRESSION_SYSTEM: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: M5; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPIC9; MOL_ID: 2; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_COMMON: ALPACA; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: ROSETTA2 PLYSS; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PETHSUK 0 0 0 0 0 0 crystal 2.85A 19.40% VHH 28-JAN-16 20160128 HYDROLASE / HYDROLASE INHIBITOR CRYSTAL STRUCTURE OF THROMBIN - ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH - A204) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CPB2; EXPRESSION_SYSTEM: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: M5; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPIC9; MOL_ID: 2; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_COMMON: ALPACA; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN6 0 0 0 0 0 0 crystal 3.05A 18.10% VHH 28-JAN-16 20160128 HYDROLASE / HYDROLASE INHIBITOR CRYSTAL STRUCTURE OF THROMBIN - ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH TWO INHIBITORY NANOBODIES ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CPB2; EXPRESSION_SYSTEM: PICHIA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: M5; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPIC9; MOL_ID: 2; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_COMMON: ALPACA; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN6; MOL_ID: 3; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_COMMON: ALPACA; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: WK6; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PHEN6 0 0 0 0 0 0 crystal 3.00A 19.00% VHH 28-JAN-16 20160128 IMMUNE SYSTEM MONOMERIC IGG4 FC ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG4; EXPRESSION_SYSTEM: MAMMALIAN EXPRESSION VECTOR PCK9; EXPRESSION_SYSTEM_TAXID: 943934 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.95A 21.20% FC 28-JAN-16 20160128 IMMUNE SYSTEM GLYCOSYLATED, DISULFIDE - LINKED KNOB - INTO - HOLE FC FRAGMENT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-EBNA; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-EBNA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 21.50% FC 01-FEB-16 20160201 IMMUNE SYSTEM GLYCOSYLATED KNOB - KNOB FC FRAGMENT (P212121) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-EBNA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.89A 22.70% FC 01-FEB-16 20160201 IMMUNE SYSTEM GLYCOSYLATED KNOB - KNOB FC FRAGMENT (P6122) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-EBNA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.80A 19.90% FC 01-FEB-16 20160201 IMMUNE SYSTEM GLYCOSYLATED, DISULFIDE - LINKED HOLE - HOLE FC FRAGMENT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-EBNA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.90A 17.80% FC 01-FEB-16 20160201 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH AMIDATED MEDITOPE MOLECULE: AMIDATED MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 16.80% FAB 01-FEB-16 20160201 IMMUNE SYSTEM STRUCTURE OF IGE COMPLEXED WITH OMALIZUMAB ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: HEL-214; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; EXPRESSION_SYSTEM_TAXID: 7108 0 0 0 0 0 0 crystal 2.50A 22.10% FAB 01-FEB-16 20160201 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SINGLE DOMAIN CATALYTIC ANTIBODY 3D8 - VH ? ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GAYKRGYAMDY crystal 1.90A 22.00% HC-dimer 04-FEB-16 20160204 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1 - 69 / IGKV1 - 39 ? ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPLT 5 SYAIS 17 GIIPIFGTANYAQKFQG 10 YDGIYGELDF crystal 2.60A 20.70% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1 - 69 / IGKV3 - 11 ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWPLT 5 SYAIS 17 GIIPIFGTANYAQKFQG 10 YDGIYGELDF crystal 1.90A 19.30% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1 - 69 / IGKV3 - 20 ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPLT 5 SYAIS 13 MGGIIPIFQKFQG 10 YDGIYGELDF crystal 3.30A 20.40% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1 - 69 / IGKV4 - 1 ? ? ? HOMO SAPIENS 17 CKSSQSVLYSSNNKNYL 7 YWASTRE 10 CQQYYSTPLT 5 SYAIS 17 GIIPIFGTANYAQKFQG 10 YDGIYGELDF crystal 1.92A 16.80% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 23 / IGKV1 - 39 ? ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPLT 5 SYAMS 17 AISGSGGSTYYADSVKG 10 YDGIYGELDF crystal 2.80A 24.30% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 23 / IGKV3 - 11 MOLECULE: CNTO388 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWPLT 5 SYAMS 17 AISGSGGSTYYADSVKG 10 YDGIYGELDF crystal 2.00A 20.70% ? 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 23 / IGKV3 - 20 ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPLT 5 SYAMS 17 AISGSGGSTYYADSVKG 10 YDGIYGELDF crystal 2.25A 22.10% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 23 / IGKV4 - 1 ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRES 9 QQYYSTPLT 5 SYAMS 17 AISGSGGSTYYADSVKG 7 YDGELDF crystal 2.00A 21.60% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 53 / IGKV1 - 39 ? ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPLT 5 SNYMS 16 VIYSGGSTYYADSVKG 10 YDGIYGELDF crystal 2.70A 19.50% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 53 / IGKV3 - 11 ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWPLT 5 SNYMS 16 VIYSGGSTYYADSVKG 10 YDGIYGELDF crystal 2.30A 30.20% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 53 / IGKV3 - 20 ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPLT 5 SNYMS 16 VIYSGGSTYYADSVKG 10 YDGIYGELDF crystal 2.22A 23.00% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3 - 53 / IGKV4 - 1 ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRES 9 QQYYSTPLT 5 SNYMS 16 VIYSGGSTYYADSVKG 10 YDGIYGELDF crystal 2.50A 25.40% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV5 - 51 / IGKV3 - 11 ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWPLT 5 SYWIG 17 IIYPGDSDTRYSPSFQG 7 YDGILDF crystal 2.50A 18.10% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV5 - 51 / IGKV3 - 20 ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPLT 5 SYWIG 17 IIYPGDSDTRYSPSFQG 7 YDGELDF crystal 1.65A 17.30% FAB 05-FEB-16 20160205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV5 - 51 / IGKV4 - 1 ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRES 9 QQYYSTPLT 5 SYWIG 17 IIYPGDSDTRYSPSFQG 10 YDGIYGELDF crystal 1.95A 19.50% FAB 05-FEB-16 20160205 IMMUNE SYSTEM STRUCTURE OF CETUXIMAB FAB WITH CYCLIC F3Q VARIANT OF THE MEDITOPE MOLECULE: MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.55A 16.20% FAB 08-FEB-16 20160208 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN ASTROVIRUS 2 NEUTRALIZING MONOCLONAL ANTIBODY PL - 2 FAB FRAGMENT AT 1.9 A RESOLUTION ? ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTFPPT 5 DYGVH 16 VIWTGGSTDYNAAFIS 9 PYYGNVMDY crystal 1.90A 18.20% FAB 09-FEB-16 20160209 IMMUNE SYSTEM SCFV 2D10 COMPLEXED WITH ALPHA 1,6 MANNOBIOSE ? ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.55A 17.00% scFv 12-FEB-16 20160212 IMMUNE SYSTEM STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH ECULIZUMAB MOLECULE: COMPLEMENT C5; SYNONYM: C3 AND PZP - LIKE ALPHA - 2 - MACROGLOBULIN DOMAIN - CONTAINING PROTEIN 4; ? ? HOMO SAPIENS 11 GASENIYGALN 7 GATNLAD 9 QNVLNTPLT 5 NYWIQ 17 EILPGSGSTEYTENFKD 13 YFFGSSPNWYFDV crystal 4.20A 20.60% FAB 15-FEB-16 20160215 IMMUNE SYSTEM X - RAY STRUCTURE OF THE FAB FRAGMENT OF 8B6, A MURINE MONOCLONAL ANTIBODY SPECIFIC FOR THE HUMAN SEROTONIN TRANSPORTER ? ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 1.62A 17.90% FAB 16-FEB-16 20160216 MEMBRANE PROTEIN X - RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH PAROXETINE AT THE CENTRAL SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.14A 24.00% ? 16-FEB-16 20160216 MEMBRANE PROTEIN X - RAY STRUCTURE OF THE TS2 HUMAN SEROTONIN TRANSPORTER MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 4.53A 28.20% ? 16-FEB-16 20160216 MEMBRANE PROTEIN X - RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH S - CITALOPRAM AT THE CENTRAL SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.15A 24.20% ? 16-FEB-16 20160216 MEMBRANE PROTEIN X - RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH S - CITALOPRAM AT THE CENTRAL AND ALLOSTERIC SITES MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.24A 23.50% ? 16-FEB-16 20160216 MEMBRANE PROTEIN X - RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH BR - CITALOPRAM AT THE CENTRAL SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.40A 25.10% ? 16-FEB-16 20160216 MEMBRANE PROTEIN X - RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH S - CITALOPRAM AT THE CENTRAL SITE AND BR - CITALOPRAM AT THE ALLOSTERIC SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.49A 24.60% ? 16-FEB-16 20160216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FM318, A RECOMBINANT FAB ADOPTED FROM CETUXIMAB MOLECULE: FM318_LIGHT_CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS/MUS MUSCULUS XENOGRAFT 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 1.92A 16.80% FAB 16-FEB-16 20160216 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 CLADE A BG505 FUSION PEPTIDE (RESIDUE 512 - 520) IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODY VRC34.01 FAB MOLECULE: HIV - 1 CLADE A BG505 FUSION PEPTIDE (RESIDUE 512 - 520); ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVRNELA 7 YASTLQS 9 QHMSSYPLT 5 GNALH 17 WINPHSGDTTTSQKFQG 13 DKYYGNEAVGMDV crystal 1.54A 16.10% FAB 18-FEB-16 20160218 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING HIV - 1 FUSION PEPTIDE - TARGETING ANTIBODY VRC34.01 FAB ? ? ? HOMO SAPIENS 11 RASQGVRNELA 7 YASTLQS 9 QHMSSYPLT 5 GNALH 17 WINPHSGDTTTSQKFQG 13 DKYYGNEAVGMDV crystal 2.66A 18.90% FAB 18-FEB-16 20160218 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH V3 LOOP - TARGETING ANTIBODY PGT122 FAB AND FUSION PEPTIDE - TARGETING ANTIBODY VRC34.01 FAB MOLECULE: BG505 SOSIP.664 GP41; SYNONYM: ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 13 - 1 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 18 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 19 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 21 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 25 ENV POLYPROTEIN, ENDOGENOUS RETROVIRUS GROUP K MEMBER 6 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 8 ENV POLYPROTEIN,ENDOGENOUS RETROVIRUS GROUP K MEMBER 9 ENV POLYPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGVRNELA 7 YASTLQS 9 QHMSSYPLT 5 GNALH 17 WINPHSGDTTTSQKFQG 13 DKYYGNEAVGMDV crystal 4.30A 28.30% FAB 18-FEB-16 20160218 IMMUNE SYSTEM HHH1 FAB FRAGMENT ? ? ? HOMO SAPIENS 13 QSSRSVWNNNFLS 7 DASKLAS 10 AGDLSDWIHT 5 NYHMS 16 FIDTGGSAAYAPWAKG 10 GAPAWGTANV crystal 1.77A 18.40% FAB 19-FEB-16 20160219 IMMUNE SYSTEM HMM5 FAB IN COMPLEX WITH DISACCHARIDE WITH DISACCHARIDE ? ? HOMO SAPIENS 13 QSSQSVYGNNYLA 7 RASTLAS 10 LGYYNGVINV 5 TYNIH 16 VIDTGGGTYFASWAKG 10 GFDYSASTNL crystal 1.80A 16.60% FAB 19-FEB-16 20160219 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 3BNC55 FAB IN COMPLEX WITH 426C.TM4DELTAV1 - 3 GP120 MOLECULE: 426C.TM4DV1 - 3 P120; ENGINEERED: YES; ? ? HOMO SAPIENS 8 QTSAGYLN 7 DGSRLVT 5 QVYEF 5 DYFIY 17 WINPLTSQPSYPSRFQG 10 RHSDYCDFDI crystal 3.00A 25.20% FAB 20-FEB-16 20160220 IMMUNE SYSTEM HUMAN ANTIBODY 6639 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ H1 X - 181 MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 17 - 344; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVDSSSLA 7 AGSSRAT 9 QQCGNSPWT 5 SYWIG 17 IINPRDSDTRYSPSFQG 16 VVADREGFGYYYGMDV crystal 3.39A 21.60% ? 22-FEB-16 20160222 IMMUNE SYSTEM UCA FAB (UNBOUND) FROM 6515 LINEAGE MOLECULE: UCA HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPWT 5 SYWIG 17 IIYPGDSDTRYSPSFQG 16 VVADREGFGYYYGMDV crystal 2.40A 20.90% FAB 22-FEB-16 20160222 IMMUNE SYSTEM 6652 FAB (UNBOUND) MOLECULE: 6652 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVFSTFLA 7 AASRRAA 9 QQSESSPWT 5 KFWIA 17 VIHPGDSDSTYNPSFQG 16 VVGDREGFGYHYGLDV crystal 1.71A 21.20% FAB 22-FEB-16 20160222 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH CQFDLSTRRLRCGGSK MEDITOPE MOLECULE: MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.60A 17.90% FAB 23-FEB-16 20160223 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH LINEAR MEDITOPE MOLECULE: MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.50A 16.20% FAB 23-FEB-16 20160223 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH GQFDLSTRRLKG PEPTIDE MOLECULE: MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.55A 17.40% FAB 23-FEB-16 20160223 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH AMINOHEPTANOIC ACID - LINKED MEDITOPE MOLECULE: CYCLIC MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 16.30% FAB 23-FEB-16 20160223 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH MPT - CYS MEDITOPE MOLECULE: MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.49A 17.50% FAB 23-FEB-16 20160223 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF VRC01C - HUGL2 FAB FROM AN HIV - 1 NAIVE DONOR IN COMPLEX WITH WITH A GERMLINE - TARGETING GP120 ENGINEERED OUTER DOMAIN EOD - GT8 AT 2.16 A MOLECULE: GERMLINE - TARGETING HIV - 1 GP120 ENGINEERED OUTER DOMAIN EOD - GT8; ENGINEERED: YES ? ? HOMO SAPIENS 9 KSSQKNYLA 7 WASTRES 5 QQYYS 5 GYYMH 17 WINPNSGGTNYAQKFQG 9 ISGSYSFDY crystal 2.16A 19.10% FAB 25-FEB-16 20160225 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF VRC01C - HUGL2 FAB FROM AN HIV - 1 NAIVE DONOR IN COMPLEX WITH WITH A GERMLINE - TARGETING GP120 ENGINEERED OUTER DOMAIN EOD - GT8 AT 2.44 A MOLECULE: GERMLINE - TARGETING HIV - 1 GP120 ENGINEERED OUTER DOMAIN EOD - GT8; ENGINEERED: YES ? ? HOMO SAPIENS 9 KSSQKNYLA 7 WASTRES 5 QQYYS 5 GYYMH 17 WINPNSGGTNYAQKFQG 9 ISGSYSFDY crystal 2.44A 19.30% FAB 25-FEB-16 20160225 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNBOUND VRC01C - HUGL2 FAB FROM AN HIV - 1 NAIVE DONOR AT 1.82 A ? ? ? HOMO SAPIENS 11 KSSQNNKNYLA 7 WASTRES 5 QQYYS 5 GYYMH 17 WINPNSGGTNYAQKFQG 9 ISGSYSFDY crystal 1.82A 20.70% FAB 25-FEB-16 20160225 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BCR FAB FRAGMENT FROM SUBSET #2 CASE P11475 ? ? ? HOMO SAPIENS 11 AGNNIGSKSVH 7 YDSDRPS 12 QVWDSGSDHPWV 5 SYSMN 17 SIISSSSYIYYADSVKG 7 DQNAMDV crystal 2.29A 18.30% FAB 26-FEB-16 20160226 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - GLIADIN 1002 - 1E01 FAB FRAGMENT IN COMPLEX OF PEPTIDE PLQPEQPFP MOLECULE: PEPTIDE PRO - LEU - GLN - PRO - GLU - GLN - PRO - PHE - PRO; ENGINEERED: YES ? ? HOMO SAPIENS 12 TLSSGHSSYVIA 7 VNSDGSH 13 DYYCQTWGAGILV 5 TYAMS 17 GISGSGGSTYYADSVKG 14 FSGKDCSGTSCRDY crystal 2.35A 20.70% FAB 26-FEB-16 20160226 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - GLIADIN 1002 - 1E01 FAB FRAGMENT IN COMPLEX OF PEPTIDE PLQPQQPFP MOLECULE: PEPTIDE PRO - LEU - GLN - PRO - GLN - GLN - PRO - PHE - PRO; ENGINEERED: YES ? ? HOMO SAPIENS 12 TLSSGHSSYVIA 7 VNSDGSH 13 DYYCQTWGAGILV 5 TYAMS 17 GISGSGGSTYYADSVKG 14 FSGKDCSGTSCRDY crystal 1.97A 19.20% FAB 27-FEB-16 20160227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NIH45 - 46 FAB GERMLINE PRECURSOR IN COMPLEX WITH 426C.TM1DELTAV1 - 3 GP120 MOLECULE: 426C.TM1DELTAV1 - 3 GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 16 GKYCTARDYYNWDFQH crystal 3.39A 28.00% FAB 28-FEB-16 20160228 IMMUNE SYSTEM / SIGNALING PROTEIN STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56 - 5 DAB ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD40, TNFRSF5; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_STRAIN: HEK293; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: HB2151; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PDOM13 0 0 0 0 0 0 crystal 3.30A 26.90% DAB 29-FEB-16 20160229 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOVINE FAB B11 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTGGTAGYNPGLKT 26 VYQKTTQKKNCPDDYTECYGGACDGT crystal 2.06A 19.80% FAB 29-FEB-16 20160229 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - GLIADIN 1002 - 1E01 FAB FRAGMENT ? ? ? HOMO SAPIENS 12 TLSSGHSSYVIA 7 VNSDGSH 13 DYYCQTWGAGILV 5 TYAMS 17 GISGSGGSTYYADSVKG 5 FSRDY crystal 1.64A 20.20% FAB 01-MAR-16 20160301 IMMUNE SYSTEM STRUCTURE OF THE UNLIGANDED ANTI - HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 ? ? ? HOMO SAPIENS 13 AGTKSNIGDCSVS 7 QNNNRPS 11 LSYDTSFSGWR 7 SSDTAVV 16 AIYWDDVEHINPSLKS 15 VRFVSGGYYTDRIDS crystal 2.80A 21.20% FAB 01-MAR-16 20160301 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - GLIADIN 1002 - 1E03 FAB FRAGMENT IN COMPLEX OF PEPTIDE PLQPEQPFP MOLECULE: PEPTIDE PRO - LEU - GLN - PRO - GLU - GLN - PRO - PHE - PRO; ENGINEERED: YES; ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRES 10 QQYYRTPPLT 5 NAWFN 19 RIKTNTDGGTTDYAAPVKG 13 GEPLVNHITILDY crystal 2.50A 21.20% FAB 02-MAR-16 20160302 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOVINE FAB E03 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 NIDTGGITGYNPGLKS 26 VHQKTLEVRSCPDGSRLIGNDCRNED crystal 2.20A 20.60% FAB 02-MAR-16 20160302 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - GLIADIN 1002 - 1E03 FAB FRAGMENT ? ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRES 10 QQYYRTPPLT 5 NAWFN 19 RIKTNTDGGTTDYAAPVKG 13 GEPLVNHITILDY crystal 1.65A 19.80% FAB 03-MAR-16 20160303 TRANSFERASE X - RAY STRUCTURE OF THE N - TERMINAL DOMAIN OF HUMAN DOUBLECORTIN IN COMPLEX WITH FAB MOLECULE: NEURONAL MIGRATION PROTEIN DOUBLECORTIN; FRAGMENT: N - TERMINAL DOMAIN, UNP RESIDUES 133 - 221; SYNONYM: DOUBLIN,LISSENCEPHALIN - X,LIS - X; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQIVDTAVA 7 LASNRHT 9 LQHWNYPLT 5 DDYVH 17 RIDPANGATKYAPKFQD 6 SKYFDS crystal 2.06A 20.10% FAB 03-MAR-16 20160303 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BOVINE FAB A01 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTSGTTGYNSGLKS 26 VHQETSRRGPDGYSWICECSSGTYTC crystal 2.00A 21.40% FAB 04-MAR-16 20160304 IMMUNE SYSTEM NANOBODY TARGETING HUMAN VSIG4 IN SPACEGROUP C2 MOLECULE: V - SET AND IMMUNOGLOBULIN DOMAIN - CONTAINING PROTEIN 4; FRAGMENT: UNP RESIDUES 19 - 232; SYNONYM: PROTEIN Z39IG; ENGINEERED: YES ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 SYGMG 17 AIRWNGGSTYYADSVKG 16 GRWDKYGSSFQDEYDY crystal 1.23A 17.20% HC-dimer 06-MAR-16 20160306 IMMUNE SYSTEM NANOBODY TARGETING HUMAN VSIG4 IN SPACEGROUP P212121 MOLECULE: V - SET AND IMMUNOGLOBULIN DOMAIN - CONTAINING PROTEIN 4; FRAGMENT: UNP RESIDUES 19 - 232; SYNONYM: PROTEIN Z39IG; ENGINEERED: YES; ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 SYGMG 17 AIRWNGGSTYYADSVKG 16 GRWDKYGSSFQDEYDY crystal 1.80A 18.50% HC-dimer 06-MAR-16 20160306 IMMUNE SYSTEM NANOBODY TARGETING MOUSE VSIG4 IN SPACEGROUP P212121 MOLECULE: PROTEIN VSIG4; FRAGMENT: IGV DOMAIN, UNP RESIDUES 19 - 139; ENGINEERED: YES ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 SYGMG 17 AIRWNGGSTYYADSVKG 16 GRWDKYGSSFQDEYDY crystal 1.20A 15.70% HC-dimer 06-MAR-16 20160306 IMMUNE SYSTEM NANOBODY TARGETING MOUSE VSIG4 IN SPACEGROUP P3221 MOLECULE: PROTEIN VSIG4; FRAGMENT: IGV DOMAIN, UNP RESIDUES 19 - 139; ENGINEERED: YES ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 SYGMG 17 AIRWNGGSTYYADSVKG 16 GRWDKYGSSFQDEYDY crystal 2.10A 24.50% HC-dimer 06-MAR-16 20160306 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH 4 - BROMOPHENYLALANINE MEDITOPE VARIANT MOLECULE: MEDITOPE VARIANT; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.50A 18.00% FAB 08-MAR-16 20160308 TRANSFERASE X - RAY STRUCTURE OF THE C - TERMINAL DOMAIN OF HUMAN DOUBLECORTIN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_COMMON: LLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DCX, DBCN, LISX; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.81A 19.70% Nanobody 09-MAR-16 20160309 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 - S74W FAB IN COMPLEX WITH AN HIV - 1 GP41 PEPTIDE. MOLECULE: GP41 MPER PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 3.29A 23.30% FAB 10-MAR-16 20160310 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8V4 FAB IN COMPLEX WITH AN HIV - 1 GP41 PEPTIDE. MOLECULE: GP41 MPER PEPTIDE; FRAGMENT: UNP RESIDUES 645 - 673; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAESVKG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.40A 19.30% FAB 10-MAR-16 20160310 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH 3 - BROMOPHENYLALANINE MEDITOPE VARIANT MOLECULE: MEDITOPE VARIANT; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 16.60% FAB 11-MAR-16 20160311 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RECOMBINANT HIGHEST FIBRILLOGENIC NATURAL MUTANT (OBTAINED FROM PATIENT AR) DERIVED FROM LAMBDA 6 LIGHT CHAIN VARIABLE DOMAIN ? LAMBDA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: W3110; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PSYN1 13 TGSGGSIADSFVQ 7 DDNQRPS 12 YCQSYNSNHHVV 0 N/A 0 N/A 0 N/A crystal 1.70A 17.60% LC-dimer 11-MAR-16 20160311 IMMUNE SYSTEM STRUCTURE OF A TRANSGLUTAMINASE 2 - SPECIFIC AUTOANTIBODY 693 - 10 - B06 FAB FRAGMENT MOLECULE: HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 10 QQSYSNLMYS 5 SYWIG 17 IIYPADSDTRYSPSFQG 14 LRMIGFDKNAPLDY crystal 1.70A 274000.00% FAB 16-MAR-16 20160316 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - RSV F FAB 14N4 ? ? ? HOMO SAPIENS 11 RASQSISSWLA 7 DASSLES 10 QQYNTYSWWT 5 SKYMT 16 VIYGGGSTYYADSVVG 13 RLGVRATTGDLDY crystal 2.00A 19.50% FAB 16-MAR-16 20160316 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH 2 - BROMOPHENYLALANINE MEDITOPE VARIANT MOLECULE: MEDITOPE VARIANT; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.51A 18.60% FAB 16-MAR-16 20160316 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH ARG9CIR MEDITOPE VARIANT MOLECULE: MEDITOPE VARIANT; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 16.70% FAB 18-MAR-16 20160318 PEPTIDE BINDING PROTEIN BC2 NANOBODY IN COMPLEX WITH THE BC2 PEPTIDE TAG ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_COMMON: ALPACA; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 0 0 0 0 0 crystal 1.00A 12.90% Nanobody 21-MAR-16 20160321 PEPTIDE BINDING PROTEIN BC2 NANOBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_COMMON: ALPACA; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.80A 19.10% Nanobody 21-MAR-16 20160321 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH ARG8CIR MEDITOPE VARIANT MOLECULE: MEDITOPE VARIANT; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 17.90% FAB 21-MAR-16 20160321 IMMUNE SYSTEM ANTI - CD20 MONOCLONAL ANTIBODY FC FRAGMENT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: BOS TAURUS; EXPRESSION_SYSTEM_TAXID: 9913 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.05A 19.00% FC 21-MAR-16 20160321 IMMUNE SYSTEM ANTI - CD20 MONOCLONAL ANTIBODY FC FRAGMENT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: BOS TAURUS; EXPRESSION_SYSTEM_TAXID: 9913; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: BOS TAURUS; EXPRESSION_SYSTEM_TAXID: 9913 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.34A 22.60% FC 22-MAR-16 20160322 IMMUNE SYSTEM CYTOKINE ANTIBODY COMPLEX MOLECULE: THYMIC STROMAL LYMPHOPOIETIN; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: BEFORE CRYSTALLISATION, THE N - TERMINAL HIS - TAG (RESIDUES 1 - 17, MGSSHHHHHHSSGLVPR) WAS REMOVED BY THROMBIN CLEAVAGE. RESIDUES 127 TO 131 OF TSLP (127 - RRKRK - 131) (ACCORDING TO THE REFERENCE SEQUENCE NUMBERING SCHEME FOR TSLP) WERE DELETED IN THE CONSTRUCT USED FOR CRYSTALLIZATION.; ? ? HOMO SAPIENS 11 GGNNLGSKSVH 7 DDSDRPS 11 QVWDSSSDHVV 5 TYGMH 17 VIWYDGSNKHYADSVKG 13 APQWELVHEAFDI crystal 2.30A 19.00% FAB 28-MAR-16 20160328 HYDROLASE TORSINA - LULL1 COMPLEX, H. SAPIENS, BOUND TO VHH - BS2 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: TOR1A, DQ2, DYT1, TA, TORA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: LOBSTR; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: TOR1AIP2, IFRG15, LULL1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: LOBSTR; MOL_ID: 3; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: LOBSTR 0 0 0 0 0 0 crystal 1.40A 14.40% VHH 29-MAR-16 20160329 HYDROLASE TORSINADELTAE - LULL1 COMPLEX, H. SAPIENS, BOUND TO VHH - BS2 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: TOR1A, DQ2, DYT1, TA, TORA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: LOBSTR; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: TOR1AIP2, IFRG15, LULL1; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: LOBSTR; MOL_ID: 3; ORGANISM_SCIENTIFIC: VICUGNA PACOS; ORGANISM_TAXID: 30538; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: LOBSTR 0 0 0 0 0 0 crystal 1.40A 14.90% VHH 29-MAR-16 20160329 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB 14N4 IN COMPLEX WITH POST - FUSION RSV F MOLECULE: FUSION GLYCOPROTEIN F0; FRAGMENT: UNP RESIDUES 26 - 98; SYNONYM: PROTEIN F; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 DASSLES 10 QQYNTYSWWT 5 SKYMT 16 VIYGGGSTYYADSVVG 13 RLGVRATTGDLDY crystal 4.08A 25.80% FAB 30-MAR-16 20160330 HORMONE RECEPTOR / IMMUNE SYSTEM HUMAN INSULIN RECEPTOR DOMAINS L1 - CR IN COMPLEX WITH PEPTIDE S519C16 AND 83 - 7 FV MOLECULE: PEPTIDE S519C16; ENGINEERED: YES; OTHER_DETAILS: 16 C - TERMINAL RESIDUES OF PEPTIDE S519: SER - LEU - ASP - GLU - SER - PHE - TYR - ASP - TRP - PHE - GLU - ARG - GLN - LEU; ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNFLA 7 WASTRES 8 QQYFRYRT 5 AYGVN 16 MIWGDGNTDYNSALKS 10 DPYGSKPMDY crystal 3.27A 22.70% FV 30-MAR-16 20160330 HYDROLASE / IMMUNE SYSTEM RTA - V1C7 MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 40 - 294; EC: 3.2.2.22; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 FTLDYYA 18 LSSISSSSDGFTSYSDSV 17 AARLGGWASFSPQEYDY crystal 1.80A 17.50% HC-dimer 01-APR-16 20160401 HYDROLASE / IMMUNE SYSTEM V5E1 - RTA COMPLEX MOLECULE: RICIN; FRAGMENT: UNP RESIDUES 39 - 302; EC: 3.2.2.22; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YYTAG 19 VACISAGGGVTYYTGSVQG 17 DLEYSQIMPSCRGSYGV crystal 1.70A 16.40% HC-dimer 01-APR-16 20160401 METAL TRANSPORT KCSA IN VITRO MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; FRAGMENT: UNP RESIDUES 22 - 117; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.85A 22.20% FAB 10-APR-16 20160410 TOXIN CRYSTAL STRUCTURE OF THE HIGB2 TOXIN IN COMPLEX WITH NB2 MOLECULE: TOXIN HIGB - 2; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YYAIG 17 CISSSGGTTNYADSVKG 12 DFACPLIREYDY crystal 2.49A 20.40% HC-dimer 12-APR-16 20160412 TOXIN CRYSTAL STRUCTURE OF THE HIGB2 TOXIN IN COMPLEX WITH NB6 MOLECULE: TOXIN HIGB - 2; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYAMR 17 FISSVGGSTNYADSVKG 8 RLSLISDS crystal 1.85A 19.80% HC-dimer 12-APR-16 20160412 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PD - L1 COMPLEXED WITH A NANOBODY AT 1.7 ANGSTRON RESOLUTION MOLECULE: PROGRAMMED CELL DEATH 1 LIGAND 1; FRAGMENT: UNP RESIDUES 18 - 132; SYNONYM: PROGRAMMED DEATH LIGAND 1,B7 HOMOLOG 1,B7 - H1; ENGINEERED: YES ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 RRCMA 17 KLLTTSGSTYLADSVKG 19 DSFEDPTCTLVTSSGAFQY crystal 1.70A 18.00% HC-dimer 17-APR-16 20160417 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF ZIKA VIRUS ENVELOPE PROTEIN IN COMPLEX WITH A FLAVIVIRUS BROADLY - PROTECTIVE ANTIBODY MOLECULE: ENVELOPE PROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 11 CKASQHVGSAV 7 HSASNRY 9 CQQYNSYPT 5 EYTMH 17 GIDPNNGGTNYNQKFKG 8 RDYYALDY crystal 3.00A 23.00% ? 21-APR-16 20160421 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HER2 BINDING IGG1 - FC (FCAB STAB19) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_TISSUE: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: PTT5 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.66A 20.00% FC 22-APR-16 20160422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG1 - FC ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_VECTOR: PTT5 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.79A 18.30% FC 22-APR-16 20160422 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HER2 BINDING IGG1 - FC (FCAB H10 - 03 - 6) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PTT5 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.82A 22.80% FC 22-APR-16 20160422 HYDROLASE / ANTIBODY X - RAY STRUCTURE OF FURIN IN COMPLEX WITH THE INHIBITORY ANTIBODY NB14 MOLECULE: FURIN; SYNONYM: DIBASIC - PROCESSING ENZYME,PAIRED BASIC AMINO ACID RESIDUE - CLEAVING ENZYME,PACE; EC: 3.4.21.75; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 SYSMY 17 SINRVGSNTDYADSVKG 8 GMYAAPPW crystal 2.00A 16.50% HC-dimer 29-APR-16 20160429 IMMUNE SYSTEM X - RAY STRUCTURE OF THE FURIN INHIBITORY ANTIBODY NB14 MOLECULE: CAMELID VHH FRAGMENT; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 SYSMY 17 SINRVGSNTDYADSVKG 8 GMYAAPPW crystal 2.27A 19.10% HC-dimer 29-APR-16 20160429 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB MOLECULE: 10E8 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 3.04A 18.90% FAB 01-MAY-16 20160501 IMMUNE SYSTEM ANTIBODY FAB FRAGMENT COMPLEX IMMUNE SYSTEM ANTIBODY FAB FRAGMENT COMPLEX ? ? HOMO SAPIENS 12 RASQSLSSKYLA 7 GASSRAT 9 QQYDGVPRT 5 SYWMH 17 AVSPGNSDTSYNEKFKG 10 SRYGNNALDY crystal 2.53A 20.00% FAB 01-MAY-16 20160501 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 GHV - GLV ANTIGEN - BINDING FRAGMENT. MOLECULE: 10E8 GHV; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QGDSLRSYYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMS 19 RIKSKTDGGTTDYAAPVKG 12 TGKYPGEEYFQD crystal 1.70A 23.50% ? 02-MAY-16 20160502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VRC03 GHVGLV ANTIGEN - BINDING FRAGMENT. MOLECULE: VRC03 GHV HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 5 QQFEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 14 RGSCDYCGDFPWQY crystal 3.21A 19.80% ? 02-MAY-16 20160502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - GLYCAN ANTIBODY FAB14.22 IN COMPLEX WITH STREPTOCOCCUS PNEUMONIAE SEROTYPE 14 TETRASACCHARIDE AT 1.75 A WITH STREPTOCOCCUS PNEUMONIAE SEROTYPE 14 TETRASACCHARIDE AT 1.75 A ? ? MUS MUSCULUS 16 RSSQTILHSDGYTYLE 7 RVYKRFS 9 FQGSYVPRT 5 EYYIH 17 YVHPKTGDVIYNQNFRG 3 WDS crystal 1.75A 16.70% FAB 02-MAY-16 20160502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNBOUND ANTI - GLYCAN ANTIBODY FAB14.22 AT 2.2 A ? ? ? MUS MUSCULUS 16 RSSQTILHSDGYTYLE 7 RVYKRFS 9 FQGSYVPRT 5 EYYIH 17 YVHPKTGDVIYNQNFRG 3 WDS crystal 2.21A 20.70% FAB 02-MAY-16 20160502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CLFA IN COMPLEX WITH THE FAB FRAGMENT OF TEFIBAZUMAB MOLECULE: CLUMPING FACTOR A; FRAGMENT: UNP RESIDUES 229 - 545; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSVLYSSNQKNYLA 7 WASTRES 8 HQYLSSYT 5 RYSVH 16 MIWGGGNTDYNSALKS 13 KGEFYYGYDGFVY crystal 2.40A 21.00% FAB 04-MAY-16 20160504 IMMUNE SYSTEM ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 12 RASQSLSSKYLA 7 GASSRAT 9 QQYDGVPRT 4 YAFT 17 GITGMFGTANYAQKFQG 11 GLYYYESSLDY crystal 2.59A 21.30% FAB 04-MAY-16 20160504 SIGNALING PROTEIN, HYDROLASE / INHIBITOR STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO CARAZOLOL AND INACTIVE - STATE STABILIZING NANOBODY, NB60 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: ENTEROBACTERIA PHAGE T4, HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 10665, 9606; GENE: ADRB2, ADRB2R, B2AR; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_TAXID: 7108; EXPRESSION_SYSTEM_CELL_LINE: SF9; EXPRESSION_SYSTEM_PLASMID: PVL1392; MOL_ID: 2; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 3.20A 25.00% Nanobody 05-MAY-16 20160505 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 GHV - MATUREL ANTIGEN - BINDING FRAGMENT. MOLECULE: 10E8 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMS 19 RIKSKTDGGTTDYAAPVKG 20 TGKYYDFWSGYPPGEEYFQD crystal 1.60A 18.60% ? 05-MAY-16 20160505 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY MR78 FAB ? ? ? HOMO SAPIENS 11 QASQVISNYLN 7 DTSNLKT 9 QQYENLQFT 7 SSSYYWG 16 SVYYSGGASYNPSLKS 15 IYGSGTFYYYFYMDV crystal 2.00A 17.20% FAB 06-MAY-16 20160506 VIRAL PROTEIN / IMMUNE SYSTEM UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 8 - RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128 MOLECULE: GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 9 TGTSNNFVS 7 DVNKRPS 10 GSLVGNWDVI 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDKWSGLHHDGVMAFSS crystal 6.92A 28.80% ? 07-MAY-16 20160507 VIRAL PROTEIN / IMMUNE SYSTEM UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 10 - RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128 MOLECULE: GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 9 TGTSNNFVS 7 DVNKRPS 10 GSLVGNWDVI 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDKWSGLHHDGVMAFSS crystal 6.31A 28.50% ? 07-MAY-16 20160507 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UIC2 FAB ? ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 10 SQSTHIPPWT 5 NYYIH 17 FISCYNGATFYNQKFKG 13 LPIQFGNFYPMDY crystal 1.65A 16.60% FAB 10-MAY-16 20160510 IMMUNE SYSTEM STRUCTURE OF MEDI8852 FAB FRAGMENT IN COMPLEX WITH H7 HA MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 340 - 509; ? ? HOMO SAPIENS 11 RTSQSLSSYTH 7 AASSRGS 5 QQSRT 7 SYNAVWN 18 RTYYRSGWYNDYAESVKS 16 SGHITVFGVNVDAFDM crystal 3.75A 22.70% FAB 11-MAY-16 20160511 IMMUNE SYSTEM STRUCTURE OF MEDI8852 FAB FRAGMENT IN COMPLEX WITH H5 HA MOLECULE: HEMAGGLUTININ; ? ? HOMO SAPIENS 11 RTSQSLSSYTH 7 AASSRGS 5 QQSRT 7 SYNAVWN 18 RTYYRSGWYNDYAESVKS 16 SGHITVFGVNVDAFDM crystal 3.70A 27.40% FAB 11-MAY-16 20160511 IMMUNE SYSTEM STRUCTURE OF MEDI8852 FAB FRAGMENT MOLECULE: MEDI8852 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 8 RTSSSYTH 7 AASSRGS 5 QQSRT 7 SYNAVWN 18 RTYYRSGWYNDYAESVKS 16 SGHITVFGVNVDAFDM crystal 1.90A 18.80% FAB 11-MAY-16 20160511 IMMUNE SYSTEM CRYSTAL STRUCTURE OF LIGAND - FREE VRC03 ANTIGEN - BINDING FRAGMENT. MOLECULE: VRC03 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 10 KASQGGNAMT 7 DTSRRAS 5 QQFEF 5 DYSIH 17 WIKPLWGAVSYARQLQG 26 TPADTAEYFCVRRGSCDYCGDFPWQY crystal 1.60A 16.10% ? 12-MAY-16 20160512 IMMUNE SYSTEM HUMAN PD - 1 ECTODOMAIN COMPLEXED WITH PEMBROLIZUMAB FAB MOLECULE: PROGRAMMED CELL DEATH PROTEIN 1; FRAGMENT: UNP RESIDUES 34 - 146; SYNONYM: HPD - 1; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASKGVSTSGYSYLH 7 LASYLES 9 QHSRDLPLT 5 NYYMY 17 GINPSNGGTNFNEKFKN 11 RDYRFDMGFDY crystal 2.90A 26.20% FAB 13-MAY-16 20160513 CELL ADHESION / IMMUNE SYSTEM HUMAN P - CADHERIN MEC1 WITH SCFV TSP7 BOUND MOLECULE: CADHERIN - 3; FRAGMENT: UNP RESIDUES 108 - 207; SYNONYM: PLACENTAL CADHERIN,P - CADHERIN; ENGINEERED: YES; ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.55A 21.70% scFv 14-MAY-16 20160514 CELL ADHESION / IMMUNE SYSTEM HUMAN P - CADHERIN EC12 WITH SCFV TSP11 BOUND MOLECULE: CADHERIN - 3; FRAGMENT: UNP RESIDUES 108 - 320; SYNONYM: PLACENTAL CADHERIN,P - CADHERIN; ENGINEERED: YES; ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.45A 22.60% scFv 14-MAY-16 20160514 SIGNALING PROTEIN NGF IN COMPLEX WITH MEDI578 SCFV MOLECULE: BETA - NERVE GROWTH FACTOR; SYNONYM: BETA - NGF; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 11 GTWDSSLSAWV 5 TYGIS 19 GIIPIFDTGNSAQSFQGRV 19 SSRIYDLNPSLTAYYDMDV crystal 3.40A 25.80% FV 16-MAY-16 20160516 IMMUNE SYSTEM CRYSTAL STRUCTURE OF EXTRACELLULAR DOMAIN OF HER2 IN COMPLEX WITH FCAB STAB19 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: ERBB2, HER2, MLN19, NEU, NGL; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: RABBIT; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO LEC1; EXPRESSION_SYSTEM_TISSUE: OVARY 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.30A 22.20% FC 19-MAY-16 20160519 IMMUNE SYSTEM CRYSTAL STRUCTURE OF LUKGH FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH A NEUTRALISING ANTIBODY MOLECULE: UNCHARACTERIZED LEUKOCIDIN - LIKE PROTEIN 1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSINSYLN 7 AASSLQS 9 QQQFDPPFT 7 SGSYYWD 16 NIYKSGSTYYNPSLKS 9 ERGMHYMDV crystal 2.84A 19.90% FAB 23-MAY-16 20160523 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VEGF BINDING IGG1 - FC (FCAB 448) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.44A 21.70% FC 24-MAY-16 20160524 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VEGF BINDING IGG1 - FC (FCAB CT6) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 22.30% FC 24-MAY-16 20160524 IMMUNE SYSTEM NIST FAB MOLECULE: HEAVY CHAIN; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSRVGYMH 7 DTSKLAS 9 FQGSGYPFT 7 TAGMSVG 16 DIWWDDKKHYNPSLKD 10 DMIFNFYFDV crystal 2.00A 16.60% FAB 27-MAY-16 20160527 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MULTIDONOR HV6 - 1 - CLASS BROADLY NEUTRALIZING INFLUENZA A ANTIBODY 56.A.09 ISOLATED FOLLOWING H5 IMMUNIZATION. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606 0 0 0 0 0 0 crystal 1.90A 19.70% VHH 31-MAY-16 20160531 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MULTIDONOR HV6 - 1 - CLASS BROADLY NEUTRALIZING INFLUENZA A ANTIBODY 56.A.09 IN COMPLEX WITH HEMAGGLUTININ HONG KONG 1968. MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVASSYLA 7 GASSRAT 9 QQYDGSQYT 7 SNRAAWN 18 RTYYRSKWYTDYAVSVKS 14 GSAMIFGIVIILES crystal 2.97A 22.70% ? 31-MAY-16 20160531 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MULTIDONOR HV6 - 1 - CLASS BROADLY NEUTRALIZING INFLUENZA A ANTIBODY 31.B.09 IN COMPLEX WITH HEMAGGLUTININ H1 A / CALIFORNIA / 04 / 2009. MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQGLVYIDGNTYLN 7 NVFTRDS 9 MQGTHWPYT 5 SYGIS 17 WISAYNGNTNYAQKLQG 13 DRPHILTGFDFDY crystal 3.39A 29.40% FV 01-JUN-16 20160601 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MULTIDONOR HV1 - 18 - CLASS BROADLY NEUTRALIZING INFLUENZA A ANTIBODY 16.A.26 IN COMPLEX WITH A / HONG KONG / 1 - 4 - MA21 - 1 / 1968 (H3N2) HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGKFLN 7 YASNLET 9 QQSNNVPHT 5 RYGIS 17 WISGYTGNTNYAQKFQG 19 DKKQGEVVLPAASFRWFAP crystal 2.50A 18.40% ? 01-JUN-16 20160601 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MULTIDONOR HV1 - 18 - CLASS BROADLY NEUTRALIZING INFLUENZA A ANTIBODY 16.G.07 IN COMPLEX WITH A / HONG KONG / 1 - 4 - MA21 - 1 / 1968 (H3N2) HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDISRWLA 7 AASSLQG 15 QQGSTFPYTSVLGTI 5 RFGMS 17 WISGYTGDTKYARSFQG 19 NRVQMEVSPATQSTWYMDL crystal 2.79A 21.90% ? 01-JUN-16 20160601 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING INFLUENZA A ANTIBODY 31.A.83 IN COMPLEX WITH HEMAGGLUTININ HONG KONG 1968. MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 11 RASQSVRSNLA 7 GASTRAT 9 QQYNHWLRT 5 DSALS 17 AISGNGGATYYADTVKG 22 DESPPIYNLMPGYYSTYYYMDV crystal 3.51A 27.20% ? 01-JUN-16 20160601 VIRAL PROTEIN / IMMUNE SYSTEM EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C2G4 AND C13C6 MOLECULE: EBOLA SURFACE GLYCOPROTEIN, GP2; ENGINEERED: YES; ? IGG HOMO SAPIENS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 7 TSGVGVG 16 LIWWDDDKYYNPSLKS 12 RDPFGYDNAMGY ElectronMicroscopy N/A N/A FAB 09-JUN-16 20160609 VIRAL PROTEIN / IMMUNE SYSTEM EBOV SGP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C13C6 AND BDBV91 MOLECULE: EBOLA SECRETED GLYCOPROTEIN; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RATESIGIYLN 7 ATSSLQS 9 QQGFSSPFS 5 DYYIH 17 WINPKSGETHYAQKFRG 15 GDLETTIFFYNAVDV ElectronMicroscopy N/A N/A FAB 09-JUN-16 20160609 VIRAL PROTEIN / IMMUNE SYSTEM EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C4G7 AND C13C6 MOLECULE: EBOLA SURFACE GLYCOPROTEIN, GP2; ENGINEERED: YES; ? IGG HOMO SAPIENS 11 RASENIYSYLA 7 NAKTLIE 9 QHHFGTPFT 5 GFSMN 17 NIDTYYGGTTYNQKFKG 10 SAYYGSTFAY ElectronMicroscopy N/A N/A FAB 09-JUN-16 20160609 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE GP120 V2 ANTIBODY RE505 - 22 FAB FROM IGH - AND IGK - HUMANIZED MOUSE ? ? ? MUS MUSCULUS, HOMO SAPIENS 12 TLSSQHSTYTIE 7 LRKDGSH 15 IYICGVGDTIKEQFV 5 DYAMH 17 GISWNSGSRGYADSVKG 7 MNGTFDY crystal 2.30A 24.20% FAB 13-JUN-16 20160613 VIRAL PROTEIN / IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF THE ADCC - POTENT ANTIBODY N60 - I3 FAB IN COMPLEX WITH HIV - 1 CLADE A / E GP120 W69A / S115W MUTANT AND M48U1. MOLECULE: M48U1 CD4 MIMETIC PEPTIDE; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGGYKYVS 7 EVSNRPS 10 SSYTSSSTWV 7 SGGYFWS 16 NIYYIGNTYYNPSLKS 12 VPRLRGGNYFDS crystal 2.98A 25.20% FAB 20-JUN-16 20160620 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CRENEZUMAB FAB ? ? IGG4 HOMO SAPIENS 16 RSSQSLVYSNGDTYLH 7 KVSNRFS 9 SQSTHVPWT 5 SYGMS 17 SINSNGGSTYYPDSVKG 3 GDY crystal 2.50A 18.60% FAB 27-JUN-16 20160627 IMMUNE SYSTEM TGFALPHA / EPIREGULIN COMPLEX WITH NEUTRALIZING ANTIBODY LY3016859 MOLECULE: PROTRANSFORMING GROWTH FACTOR ALPHA; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSIVHSTGNTYLE 7 KVSNRFS 9 FHGTHVPYT 5 DAYIN 17 WIWPGPVITYYNPKFKG 9 REVLSPFAY crystal 2.80A 20.60% FAB 27-JUN-16 20160627 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CRENEZUMAB FAB IN COMPLEX WITH ABETA MOLECULE: AMYLOID BETA; ENGINEERED: YES ? IGG4 HOMO SAPIENS 16 RSSQSLVYSNGDTYLH 7 KVSNRFS 9 SQSTHVPWT 5 SYGMS 17 SINSNGGSTYYPDSVKG 3 GDY crystal 2.32A 20.90% FAB 28-JUN-16 20160628 VIRAL PROTEIN CRYSTAL STRUCTURE OF THE HUMAN ASTROVIRUS 2 CAPSID PROTEIN SPIKE IN COMPLEX WITH A SINGLE CHAIN VARIABLE FRAGMENT OF AN ASTROVIRUS NEUTRALIZING ANTIBODY AT 3.24 - A RESOLUTION MOLECULE: CAPSID POLYPROTEIN VP90; FRAGMENT: UNP RESIDUES 429 - 644; ENGINEERED: YES; ? ? MUS MUSCULUS 13 TVSGFSLIDYGVH 7 IWTGGST 15 TGIYYCGRPYYGNVM 5 DYGVH 16 VIWTGGSTDYNAAFIS 9 PYYGNVMDY crystal 3.25A 24.30% scFv 01-JUL-16 20160701 HORMONE / HORMONE RECEPTOR / IMMUNE SYSTEM INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1,CR,L2, FNIII - 1 AND ALPHACT PEPTIDE IN COMPLEX WITH BOVINE INSULIN AND FAB 83 - 14 (REVISED STRUCTURE) MOLECULE: INSULIN; FRAGMENT: UNP RESIDUES 25 - 54; ? ? MUS MUSCULUS 11 RASQDIGGNLY 7 ATSSLDS 9 LQYSSSPWT 5 NYDIH 17 WIYPGDGSTKYNEKFKG 4 EWAY crystal 4.40A 23.10% FAB 06-JUL-16 20160706 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DEINOCOCCUS RADIODURANS MNTH, AN NRAMP - FAMILY TRANSITION METAL TRANSPORTER MOLECULE: DIVALENT METAL CATION TRANSPORTER MNTH; FRAGMENT: UNP RESIDUES 26 - 436; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YVSQSSS 9 QQSNSWPRT 5 SYGVH 16 VIWSDGSTTYNSALKS 6 EPPYGY crystal 3.94A 27.20% FAB 11-JUL-16 20160711 VIRUS / IMMUNE SYSTEM EXPANDED POLIOVIRUS IN COMPLEX WITH VHH 12B ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 3; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1; ORGANISM_TAXID: 12081; STRAIN: MAHONEY; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 4; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12; EXPRESSION_SYSTEM_TAXID: 83333 0 0 0 0 0 0 ElectronMicroscopy N/A N/A VHH 12-JUL-16 20160712 VIRUS / IMMUNE SYSTEM EXPANDED POLIOVIRUS IN COMPLEX WITH VHH 17B ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12; EXPRESSION_SYSTEM_TAXID: 83333 0 0 0 0 0 0 ElectronMicroscopy N/A N/A VHH 12-JUL-16 20160712 VIRUS / IMMUNE SYSTEM EXPANDED POLIOVIRUS IN COMPLEX WITH VHH 7A ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12; EXPRESSION_SYSTEM_TAXID: 83333 0 0 0 0 0 0 ElectronMicroscopy N/A N/A VHH 12-JUL-16 20160712 VIRAL PROTEIN / IMMUNE SYSTEM ZIKA SPECIFIC ANTIBODY, ZV - 2, BOUND TO ZIKA ENVELOPE DIII MOLECULE: ZIKA ENVELOPE DIII; FRAGMENT: UNP RESIDUES 589 - 697; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLHSGNQKNYLA 7 GASTRES 9 QNDHSYPLT 5 GYWIE 17 EIFPGSGRTKYNEKFKG 11 YYYGSYYALDY crystal 1.65A 19.20% FAB 14-JUL-16 20160714 VIRAL PROTEIN / IMMUNE SYSTEM ZIKA SPECIFIC ANTIBODY, ZV - 48, BOUND TO ZIKA ENVELOPE DIII MOLECULE: ZIKA ENVELOPE DIII; FRAGMENT: UNP RESIDUES 589 - 697; ENGINEERED: YES; ? ? MUS MUSCULUS 17 CKSSQSLLYSNNEKNYL 7 YWASARD 10 CQQYYSYPYT 5 NYWMH 17 MIHPNSGNTKYNEKFKN 7 LGNDMDY crystal 1.70A 18.80% scFv 14-JUL-16 20160714 VIRAL PROTEIN / IMMUNE SYSTEM ZIKA SPECIFIC ANTIBODY, ZV - 64, BOUND TO ZIKA ENVELOPE DIII MOLECULE: ZIKA ENVELOPE DIII; FRAGMENT: UNP RESIDUES 589 - 697; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNYLA 7 WASTRES 9 QQYYTYPYT 5 SSWMH 17 MIHPNSGSTNYNEKFKN 10 YYYDYDGMDY crystal 1.40A 15.50% FAB 14-JUL-16 20160714 VIRAL PROTEIN / IMMUNE SYSTEM ZIKA SPECIFIC ANTIBODY, ZV - 67, BOUND TO ZIKA ENVELOPE DIII MOLECULE: ZIKA ENVELOPE DIII; FRAGMENT: UNP RESIDUES 589 - 697; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQNVGTAVA 7 SASNRYT 9 QQFSSYPYT 5 SYGIS 17 VIYPRSGNTYYNEKFRG 7 ENYGSVY crystal 1.40A 15.00% FAB 14-JUL-16 20160714 IMMUNE SYSTEM HUMANIZED 10G4 ANTI - LEUKOTRIENE C4 ANTIBODY FAB FRAGMENT IN COMPLEX WITH LEUKOTRIENE C4 WITH LEUKOTRIENE C4 ? ? HOMO SAPIENS 11 RASQEISGYLG 7 AASTLDS 9 LQYASFPRT 6 SSYSWN 16 NIYYSGSTNYNPSLKS 3 PRV crystal 1.74A 19.20% FAB 14-JUL-16 20160714 ANTIVIRAL PROTEIN STRUCTURAL BASIS FOR NOROVIRUS NEUTRALIZATION BY A HBGA BLOCKING HUMAN IGA ANTIBODY MOLECULE: CAPSID PROTEIN VP1; SYNONYM: CP,P59; ENGINEERED: YES; ? IGA HOMO SAPIENS 17 KSSQSVLYKSDKKNYLA 7 WASTRES 9 QQYYSIPRT 5 THAIS 17 GIIPIFATTNYANKFQG 15 NRANRADDYDYYFDY crystal 2.30A 18.80% FAB 15-JUL-16 20160715 IMMUNE SYSTEM CRYSTAL STRUCTURE OF EXTRACELLULAR DOMAIN OF HER2 IN COMPLEX WITH FCAB H10 - 03 - 6 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: ERBB2, HER2, MLN19, NEU, NGL; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO LEC1; EXPRESSION_SYSTEM_ORGAN: OVARY; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_PLASMID: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 4.30A 32.80% FC 18-JUL-16 20160718 VIRUS / IMMUNE SYSTEM EXPANDED POLIOVIRUS IN COMPLEX WITH VHH 10E ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 2; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 3; ORGANISM_SCIENTIFIC: POLIOVIRUS TYPE 1 (STRAIN MAHONEY); ORGANISM_TAXID: 12081; STRAIN: MAHONEY; MOL_ID: 4; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12; EXPRESSION_SYSTEM_TAXID: 83333 0 0 0 0 0 0 ElectronMicroscopy N/A N/A VHH 18-JUL-16 20160718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN HIV - 1 GP120 ENGINEERED OUTER DOMAIN WITH A MAN9 GLYCAN AT POSITION N276, IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODY VRC01 MOLECULE: ENGINEERED OUTER DOMAIN OF GP120; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RTSQYGSLA 7 SGSTRAA 5 QQYEF 5 DCTLN 17 WLKPRGGAVNYARPLQG 12 GKNCDYNWDFEH crystal 3.25A 22.50% FAB 24-JUL-16 20160724 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF THE HCV1 - C1 ANTIBODY - ANTIGEN COMPLEX MOLECULE: C1 EPITOPE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 8 QQRSNWIT 5 NYGMH 17 VIWFDENNKYYADSVRG 14 DISLVRDAFIYFDF crystal 2.26A 22.00% FAB 25-JUL-16 20160725 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN ADAM10 D+C DOMAIN AND A CONFORMATION SPECIFIC MAB 8C7. MOLECULE: DISINTEGRIN AND METALLOPROTEINASE DOMAIN - CONTAINING PROTEIN 10; FRAGMENT: UNP RESIDUES 455 - 646; SYNONYM: ADAM 10,KUZBANIAN PROTEIN HOMOLOG,MAMMALIAN DISINTEGRIN - METALLOPROTEASE,MYELIN - ASSOCIATED METALLOPROTEINASE; EC: 3.4.24.81; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQNIGTNIH 7 YASESIS 9 QQSNRWPFT 5 NYWLQ 17 AIYPRDGDAKYSQKFKD 11 ANYGLYYAMDR crystal 2.76A 20.50% ? 28-JUL-16 20160728 TOXIN CRYSTAL STRUCTURE OF BONT / A RECEPTOR BINDING DOMAIN IN COMPLEX WITH VHH C2 MOLECULE: BOTULINUM NEUROTOXIN TYPE A; SYNONYM: BONT / A,BONTOXILYSIN - A,BOTOX; EC: 3.4.24.69; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 7 FRFDENT 19 DELVARYPKSGIVTYLDSV 5 NVGEF crystal 1.68A 19.30% HC-dimer 29-JUL-16 20160729 IMMUNE SYSTEM IL13 IN COMPLEX WITH TRALOKINUMAB MOLECULE: INTERLEUKIN - 13; SYNONYM: IL - 13; ENGINEERED: YES; OTHER_DETAILS: IL13 R&D SYSTEMS (RECOMBINANT HUMAN IL - 13 CAT NO:213 - ILB / CF); ? ? HOMO SAPIENS 11 GGNIIGSKLVH 7 DDGDRPS 11 QVWDTGSDPVV 5 NYGLS 17 WISANNGDTNYGQEFQG 13 DSSSSWARWFFDL crystal 1.99A 19.00% FAB 01-JUN-16 20160601 IMMUNE SYSTEM AFAMIN ANTIBODY FRAGMENT, N14 FAB, L1 - GLYCOSYLATED, CRYSTAL FORM II ? KAPPA IGG1 MUS MUSCULUS 12 TANSSVSSNYFH 7 STSNLAS 9 HQYHRSPPT 5 SYIIH 17 YINPYNDGSKYNEKFKG 9 NYGSDSLDY crystal 1.86A 19.20% FAB 04-JUN-16 20160604 IMMUNE SYSTEM AFAMIN ANTIBODY FRAGMENT, N14 FAB, L1 - GLYCOSILATED, CRYSTAL FORM I, NON - PARSIMONIOUS MODEL ? KAPPA ? MUS MUSCULUS 12 TANSSVSSNYFH 7 STSNLAS 9 HQYHRSPPT 5 SYIIH 17 YINPYNDGSKYNEKFKG 9 NYGSDSLDY crystal 1.88A 17.20% FAB 07-JUN-16 20160607 IMMUNE SYSTEM AFAMIN ANTIBODY FRAGMENT, N14 FAB, L1 - GLYCOSYLATED, CRYSTAL FORM I, PARSIMONIOUS MODEL ? KAPPA IGG1 MUS MUSCULUS 12 TANSSVSSNYFH 7 STSNLAS 9 HQYHRSPPT 5 SYIIH 17 YINPYNDGSKYNEKFKG 9 NYGSDSLDY crystal 1.88A 17.80% FAB 10-JUN-16 20160610 IMMUNE SYSTEM - VIRAL PROTEIN STRUCTURAL BASIS OF ZIKA AND DENGUE VIRUS POTENT ANTIBODY CROSS - NEUTRALIZATION MOLECULE: ENVELOPE PROTEIN E; ENGINEERED: YES; ? ? HOMO SAPIENS 11 CRASQSISTFL 7 YDASTRA 11 CQQRYNWPPYT 5 TYSMH 17 AITGEGDSAFYADSVKG 13 GYSNFYYYYTMDV crystal 2.41A 19.50% FV 17-JUN-16 20160617 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURAL BASIS OF ZIKA AND DENGUE VIRUS POTENT ANTIBODY CROSS - NEUTRALIZATION MOLECULE: POLYPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSNADTYNLVS 7 EGTKRPS 10 CSYATSRTLV 5 NHWMH 17 RINSDGSTRNYADFVKG 24 DGVRFYYDSTGYYPDSFFKYGMDV crystal 2.64A 22.40% FAB 22-JUN-16 20160622 VIRAL PROTEIN A VIRAL CAPSID:ANTIBODY COMPLEX MOLECULE: HEXON PROTEIN,HEXON CAPSID; SYNONYM: CP - H,PROTEIN II; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQSVTNDAA 7 QASTRYT 9 HQDYSSPLT 5 RYGVH 16 VIWRGGTTDYNAVFMS 9 QGSNFPLAY crystal 2.70A 16.70% ? 27-JUN-16 20160627 IMMUNE SYSTEM ROOM TEMPERATURE STRUCTURE OF HUMAN IGG4 - FC FROM CRYSTALS ANALYSED IN SITU ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG4; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 17.80% FC 05-JUL-16 20160705 IMMUNE SYSTEM AFAMIN ANTIBODY FRAGMENT, N14 FAB, L1 - GLYCOSILATED, CRYSTAL FORM II, SAME AS 5L7X, BUT ISOMORPHOUS SETTING INDEXED SAME AS 5L88, 5L9D ? KAPPA IGG1 MUS MUSCULUS 12 TANSSVSSNYFH 7 STSNLAS 9 HQYHRSPPT 5 SYIIH 17 YINPYNDGSKYNEKFKG 9 NYGSDSLDY crystal 1.86A 19.20% FAB 07-JUL-16 20160707 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF IGE FC MUTANT - P333C ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 19.10% FC 07-JUL-16 20160707 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN IGE - FC BOUND TO ITS B CELL RECEPTOR DERCD23 ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCER2, CD23A, CLEC4J, FCE2, IGEBF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.50A 26.70% FC 07-JUL-16 20160707 HYDROLASE / ANTIBODY THE CATALYTIC DOMAIN OF MURINE UROKINASE - TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7 MOLECULE: UROKINASE - TYPE PLASMINOGEN ACTIVATOR; SYNONYM: UPA; EC: 3.4.21.73; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 YYAIG 17 CISSSGGSTNYADSVKG 24 EWVPPGYGATVQALCNNAGYGMEY crystal 2.55A 17.90% HC-dimer 12-JUL-16 20160712 HYDROLASE THE P - AMINOBENZAMIDINE ACTIVE SITE INHIBITED CATALYTIC DOMAIN OF MURINE UROKINASE - TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7 MOLECULE: UROKINASE - TYPE PLASMINOGEN ACTIVATOR; SYNONYM: UPA; EC: 3.4.21.73; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 YYAIG 17 CISSSGGSTNYADSVKG 24 EWVPPGYGATVQALCNNAGYGMEY crystal 2.63A 20.70% HC-dimer 12-JUL-16 20160712 HYDROLASE / ANTIBODY THE EGR - CMK ACTIVE SITE INHIBITED CATALYTIC DOMAIN OF MURINE UROKINASE - TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7 MOLECULE: UROKINASE - TYPE PLASMINOGEN ACTIVATOR; SYNONYM: UPA; EC: 3.4.21.73; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 YYAIG 17 CISSSGGSTNYADSVKG 24 EWVPPGYGATVQALCNNAGYGMEY crystal 2.60A 18.00% HC-dimer 12-JUL-16 20160712 HYDROLASE THE CATALYTIC DOMAIN OF MURINE UROKINASE - TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ACTIVE SITE BINDING INHIBITORY NANOBODY NB22 MOLECULE: UROKINASE - TYPE PLASMINOGEN ACTIVATOR; SYNONYM: UPA; EC: 3.4.21.73; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 1 G 17 AISWSGGSTNYADSVKG 12 DLASSRDVSSWY crystal 2.30A 19.00% HC-dimer 12-JUL-16 20160712 IMMUNE SYSTEM LLAMA NANOBODY PORM_19 MOLECULE: NANOBODY; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYDMA 17 AISTKGGSTWYHDSVKG 14 GAVTYYSARYEYDY crystal 2.10A 18.90% HC-dimer 01-AUG-16 20160801 IMMUNE SYSTEM LLAMA NANOBODY PORM_02 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RYNMG 17 SISWSGDRTYGTDSVKG 12 DRFLTRSVKYDY crystal 1.50A 18.80% HC-dimer 01-AUG-16 20160801 CYTOKINE COMPLEX STRUCTURE OF HUMAN IL2 MUTANT, PROLEUKIN, WITH FAB FRAGMENT OF NARA1 ANTIBODY MOLECULE: INTERLEUKIN - 2; SYNONYM: IL - 2,T - CELL GROWTH FACTOR,TCGF; ENGINEERED: YES; ? ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPYT 5 NYLIE 17 VINPGSGGTNYNEKFKG 12 WRGDGYYAYFDV crystal 1.95A 19.40% FAB 16-AUG-16 20160816 TRANSFERASE 107_A07 FAB IN COMPLEX WITH FRAGMENT OF THE MET RECEPTOR MOLECULE: HEPATOCYTE GROWTH FACTOR RECEPTOR; SYNONYM: HGF RECEPTOR,HGF / SF RECEPTOR,PROTO - ONCOGENE C - MET,SCATTER FACTOR RECEPTOR,SF RECEPTOR,TYROSINE - PROTEIN KINASE MET; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDISNYLN 7 DASNLET 9 QQGDSFPLT 5 DYYMH 17 LVDPEDGETIYAEKFQG 11 DATTPYWGMMW crystal 2.61A 21.70% FAB 05-SEP-16 20160905 IMMUNE SYSTEM STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K - 4 LIGHT CHAIN LEN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: JM83 0 0 0 0 0 0 crystal 2.00A 18.60% ? 24-FEB-99 19990224 HYDROLASE STRUCTURE OF A SINGLE DOMAIN CAMELID ANTIBODY FRAGMENT CAB - G10S IN COMPLEX WITH THE BLAP BETA - LACTAMASE FROM BACILLUS LICHENIFORMIS MOLECULE: BETA - LACTAMASE; SYNONYM: PENICILLINASE; EC: 3.5.2.6; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NDHMG 17 AITPGTEKTYYADSVKG 16 TPYYRGSYYAASTYTY crystal 2.56A 21.70% HC-dimer 16-SEP-16 20160916 IMMUNE SYSTEM LLAMA NANOBODY PORM_01 MOLECULE: PORM NANOBODY; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYSMG 17 AISRSDNSTYYADSVKG 17 TPYGSRYYLRELREYDY crystal 1.60A 20.50% HC-dimer 29-SEP-16 20160929 IMMUNE SYSTEM SYNTHETIC NANOBODY IN COMPLEX WITH MBP MOLECULE: MALTOSE - BINDING PERIPLASMIC PROTEIN; SYNONYM: MBP,MMBP,MALTODEXTRIN - BINDING PROTEIN; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 YISYL 18 VAALYTSTGRTYYADSVK 17 AAEWGSQSPLTQWFYRY crystal 1.37A 16.90% HC-dimer 07-OCT-16 20161007 IMMUNE SYSTEM SYNTHETIC NANOBODY IN COMPLEX WITH MBP MOLECULE: MALTOSE - BINDING PERIPLASMIC PROTEIN; SYNONYM: MBP,MMBP,MALTODEXTRIN - BINDING PROTEIN; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 EHIGY 17 VAALITYTGHTYYADSV 18 AAAEWGSQSPLTQWFYRY crystal 1.60A 19.20% HC-dimer 07-OCT-16 20161007 IMMUNE SYSTEM SYNTHETIC NANOBODY IN COMPLEX WITH MBP MOLECULE: MALTOSE - BINDING PERIPLASMIC PROTEIN; SYNONYM: MBP,MMBP,MALTODEXTRIN - BINDING PROTEIN; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 HEIGY 17 VAALMTFQGQTYYADSV 18 AAAYWGKQSPLISWDYSY crystal 1.90A 21.20% HC-dimer 07-OCT-16 20161007 CYTOKINE STRUCTURE OF HUMAN TUMOR NECROSIS FACTOR (TNF) IN COMPLEX WITH THE LLAMA VHH1 MOLECULE: TUMOR NECROSIS FACTOR; SYNONYM: CACHECTIN,TNF - ALPHA,TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 2,TNF - A; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYYMG 17 NISWRGYNIYYKDSVKG 14 SILPLSDDPGWNTY crystal 2.15A 20.80% HC-dimer 13-OCT-16 20161013 CYTOKINE COMPLEX BETWEEN HUMAN TNF ALPHA AND LLAMA VHH2 MOLECULE: TUMOR NECROSIS FACTOR; SYNONYM: CACHECTIN,TNF - ALPHA,TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 2,TNF - A; ENGINEERED: YES; ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 NYWMY 17 EINTNGLITKYPDSVKG 6 SPSGFN crystal 1.90A 16.00% HC-dimer 13-OCT-16 20161013 CYTOKINE COMPLEX BETWEEN HUMAN TNF ALPHA AND LLAMA VHH3 MOLECULE: TUMOR NECROSIS FACTOR; SYNONYM: CACHECTIN,TNF - ALPHA,TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 2,TNF - A; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 DHSGYTY 17 FVARIYWSSGNTYYADS 18 CAARDGIPTSRSVESYNY crystal 2.30A 21.30% HC-dimer 13-OCT-16 20161013 IMMUNE SYSTEM STRUCTURE OF NANOBODY NB18 RAISED AGAINST TSSK FROM E. COLI T6SS MOLECULE: LLAMA NANOBODY NB8 AGAINST TSSK FROM T6SS; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IVVMA 16 SITSGGTTNYADSVKG 11 FFRRDYVGYDY crystal 1.50A 20.30% HC-dimer 13-OCT-16 20161013 SECRETION SYSTEM STRUCTURE OF TSSK FROM T6SS EAEC IN COMPLEX WITH NANOBODY NB18 MOLECULE: TYPE VI SECRETION PROTEIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 IVVMA 16 SITSGGTTNYADSVKG 11 FFRRDYVGYDY crystal 2.60A 20.80% HC-dimer 13-OCT-16 20161013 IMMUNE SYSTEM BEAT FC ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1, IGHG3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.97A 21.30% FC 17-OCT-16 20161017 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GROUP B STREPTOCOCCUS TYPE III DP2 OLIGOSACCHARIDE BOUND TO FAB NVS - 1 - 19 - 5 ? ? ? ORYCTOLAGUS CUNICULUS 13 QSSQSLYNNNRLA 7 KASTLES 12 AGYKSNSDDGTA 5 SYFMC 18 CIRSSSNEILYYASWAKG 17 DYFGEGDVFYHGGVFGL crystal 2.74A 23.80% FAB 24-OCT-16 20161024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CARDIOTOXIC BENCE - JONES LIGHT CHAIN DIMER H9 MOLECULE: BENCE - JONES LIGHT CHAIN; ? ? HOMO SAPIENS 14 TGTSSDVGGSDSVS 7 EVSQRPS 10 SSYGGDNNLF 0 N/A 0 N/A 0 N/A crystal 1.64A 18.40% LC-dimer 24-OCT-16 20161024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NON - CARDIOTOXIC BENCE - JONES LIGHT CHAIN DIMER M8 MOLECULE: LIGHT CHAIN DIMER; ? ? HOMO SAPIENS 14 TGTSSDVGAYNLVS 7 EVSKRPS 10 CSNAGSYTHV 0 N/A 0 N/A 0 N/A crystal 2.20A 19.70% LC-dimer 25-OCT-16 20161025 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CARDIOTOXIC BENCE - JONES LIGHT CHAIN DIMER H10 MOLECULE: LIGHT CHAIN DIMER; ? ? HOMO SAPIENS 13 TGNTNNIGSYPVG 6 GNSLPS 11 STWDSSLSVQV 0 N/A 0 N/A 0 N/A crystal 2.50A 24.10% LC-dimer 26-OCT-16 20161026 IMMUNE SYSTEM ENGINEERING THE THERMOSTABILITY OF NANOBODIES - NBD2 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: CAMELUS DROMEDARIUS; ORGANISM_COMMON: ARABIAN CAMEL; ORGANISM_TAXID: 9838; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 1.80A 19.80% Nanobody 28-OCT-16 20161028 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH NANOBODY MOLECULE: DIVALENT METAL CATION TRANSPORTER MNTH; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IDTAN 16 TITRDGNANYADSVKG 13 AIRTTVRTSAQEY crystal 3.10A 23.90% HC-dimer 31-OCT-16 20161031 IMMUNE SYSTEM MCL1 FAB COMPLEX IN COMPLEX WITH COMPOUND 29 MOLECULE: INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL - 1 HOMOLOG,INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL - 1; SYNONYM: BCL - 2 - RELATED PROTEIN EAT / MCL1,BCL - 2 - LIKE PROTEIN 3,BCL2 - L - 3,BCL - 2 - RELATED PROTEIN EAT / MCL1,MCL1 / EAT; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNTVN 7 SNNQRPS 11 AAWDDSLNAWV 5 SYSMN 17 SISSSSSYIYYADSVKG 10 QVGATWAFDI crystal 2.24A 18.20% FAB 16-NOV-16 20161116 IMMUNE SYSTEM MCL1 FAB COMPLEX IN COMPLEX WITH COMPOUND 21 MOLECULE: INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL - 1 HOMOLOG,INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL - 1; SYNONYM: BCL - 2 - RELATED PROTEIN EAT / MCL1,BCL - 2 - LIKE PROTEIN 3,BCL2 - L - 3,BCL - 2 - RELATED PROTEIN EAT / MCL1,MCL1 / EAT; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNTVN 7 SNNQRPS 11 AAWDDSLNAWV 5 SYSMN 17 SISSSSSYIYYADSVKG 10 QVGATWAFDI crystal 2.94A 22.90% FAB 16-NOV-16 20161116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - T4 FAB FRAGMENT WITH T4 ? ? ? MUS MUSCULUS 10 NSSSSVSYMH 7 DTSNLAS 9 QQRSSYPLT 5 SYYMS 17 AINSNGGSTYYPDTVKG 15 GDYYGSSLYYYAMDY crystal 1.90A 18.10% FAB 24-NOV-16 20161124 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - T4 FAB FRAGMENT WITH TETRAIODOBPA ? ? ? MUS MUSCULUS 10 NSSSSVSYMH 7 DTSNLAS 9 QQRSSYPLT 5 SYYMS 17 AINSNGGSTYYPDTVKG 15 GDYYGSSLYYYAMDY crystal 2.80A 22.50% FAB 24-NOV-16 20161124 IMMUNE SYSTEM T3D REOVIRUS SIGMA1 COMPLEXED WITH 9BG5 FAB FRAGMENTS MOLECULE: VIRAL ATTACHMENT PROTEIN SIGMA 1; ENGINEERED: YES; ? ? MUS MUSCULUS 12 SASSSISSNYLH 7 RTSKLAS 8 QQGSSIYT 5 GYTMN 17 LINPYNDGPSYNQNFKG 12 HYYGISYWYFDV crystal 3.00A 21.40% FAB 25-NOV-16 20161125 IMMUNE SYSTEM T1L REOVIRUS SIGMA1 COMPLEXED WITH 5C6 FAB FRAGMENTS MOLECULE: OUTER CAPSID PROTEIN SIGMA - 1; SYNONYM: SIGMA1,CELL ATTACHMENT PROTEIN,HEMAGGLUTININ; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASKSVSTSGYSYMQ 7 LASNLES 9 QHSRELPPT 5 NYAIH 16 VIWSGGSTDYNAAFIS 15 KEELYGYDGYLFFDV crystal 3.70A 26.20% FAB 25-NOV-16 20161125 IMMUNE SYSTEM A THERMALLY STABILISED VERSION OF PLASMODIUM FALCIPARUM RH5 MOLECULE: RETICULOCYTE BINDING - LIKE PROTEIN 5,RETICULOCYTE BINDING PROTEIN 5; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVEYYGTSLMQ 7 GASNVQS 9 QQSTKVPWT 5 DYGMA 17 FISNMAYSIYYADTVTG 13 AIFDYAGYWYFDV crystal 2.35A 17.90% ? 27-NOV-16 20161127 TOXIN CRYSTAL STRUCTURE OF THE HIGB2 TOXIN IN COMPLEX WITH NB8 MOLECULE: CYTOTOXIC TRANSLATIONAL REPRESSOR OF TOXIN - ANTITOXIN STABILITY SYSTEM; SYNONYM: TOXIN HIGB - 2,UNCHARACTERIZED PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IYTMG 19 TMTSSGVTTYVDSVKGRFS 13 EESRRPLGSRNTY crystal 2.60A 23.10% HC-dimer 30-NOV-16 20161130 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DC8E8 FAB IN THE COMPLEX WITH A 14 - MER TAU PEPTIDE AT PH 8.5 MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; FRAGMENT: UNP RESIDUES 615 - 628; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 1.69A 19.20% FAB 13-DEC-16 20161213 IMMUNE SYSTEM STRUCTURE OF HUMAN TRKB RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH THE FAB FRGMENT OF ANTIBODY AB20 MOLECULE: BDNF / NT - 3 GROWTH FACTORS RECEPTOR; SYNONYM: GP145 - TRKB,TRK - B,NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 2,TRKB TYROSINE KINASE,TROPOMYOSIN - RELATED KINASE B; EC: 2.7.10.1; ENGINEERED: YES; OTHER_DETAILS: FRAGMENT: LIGAND BINDING DOMAIN ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQGTHVPYT 5 DYEMH 17 TIDPETAGTAYNQKFKG 7 VTTWFAY crystal 2.59A 18.20% FAB 14-DEC-16 20161214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGE - FC EPSILON 3 - 4 ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 21.40% HC-dimer 14-DEC-16 20161214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IGE - FC EPSILON 3 - 4 ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.26A 20.30% HC-dimer 14-DEC-16 20161214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGE - FC EPSILON 3 - 4 ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.00A 20.40% HC-dimer 14-DEC-16 20161214 IMMUNE SYSTEM HUMAN IGE - FC CRYSTAL STRUCTURE ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHE; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; EXPRESSION_SYSTEM_CELL_LINE: NSO Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.75A 19.90% HC-dimer 14-DEC-16 20161214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DC8E8 FAB IN THE COMPLEX WITH A 14 - MER TAU PEPTIDE AT PH 7.5 MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; FRAGMENT: UNP RESIDUES 615 - 628; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 3.10A 22.50% FAB 15-DEC-16 20161215 TRANSPORT PROTEIN XCPQN012 IN COMPLEX WITH VHH04 MOLECULE: TYPE II SECRETION SYSTEM PROTEIN D; FRAGMENT: N - TERMINAL DOMAINS 0, 1 AND 2, UNP RESIDUES 79 - 318; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYYMG 17 SIYIRAGIPYYTDSVKG 16 SVRTTIQPFKGNYYNY crystal 2.90A 21.50% HC-dimer 15-DEC-16 20161215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DC8E8 FAB IN THE COMPLEX WITH A 30 - MER TAU PEPTIDE AT PH 6.5 MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN; FRAGMENT: UNP RESIDUES 615 - 628; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 2.75A 20.10% FAB 15-DEC-16 20161215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DC8E8 FAB IN THE COMPLEX WITH A 14 - MER TAU PEPTIDE AT PH 6.5 MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; FRAGMENT: UNP RESIDUES 615 - 628; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 2.31A 23.70% FAB 15-DEC-16 20161215 IMMUNE SYSTEM STRUCTURE OF THE UNLIGANDED FAB FROM HIV - 1 NEUTRALIZING ANTIBODY CAP248 - 2B THAT BINDS TO THE GP120 C - TERMINUS - GP41 INTERFACE, AT TWO ANGSTROM RESOLUTION. MOLECULE: CAP248 - 2B HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDIGGYKYVS 7 DVIKRPS 9 SSYTTRAYV 7 NEDYYWT 17 DIYYNSGTTHYNPSLKS 15 EASTKITDDGGAFDF crystal 1.96A 19.90% FAB 15-DEC-16 20161215 IMMUNE SYSTEM STRUCTURE OF DC8E8 FAB AT PH 6.5 CRYSTALLIZED IN SPACEGROUP P21 ? ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 1.73A 18.80% FAB 09-JAN-17 20170109 IMMUNE SYSTEM ACC1 FAB FRAGMENT IN COMPLEX WITH CITRULLINATED C1 EPITOPE OF CII (IA03) MOLECULE: IA03 PEPTIDE CONTAINING THE CITRULLINATED C1 EPITOPE OF COLLAGEN TYPE II,COLLAGEN ALPHA - 1 (II) CHAIN,IA03 PEPTIDE CONTAINING THE CITRULLINATED C1 EPITOPE OF COLLAGEN TYPE II; SYNONYM: ALPHA - 1 TYPE II COLLAGEN; ENGINEERED: YES; OTHER_DETAILS: THE C - TERMINUS IS AMINATED ? ? MUS MUSCULUS 15 RASESVDNYGISSMN 7 AASKQGS 9 QQSKGVPYT 5 DAWMD 19 EIRNKVNNHATNYAESVKG 5 LTFDY crystal 2.70A 25.30% FAB 11-JAN-17 20170111 IMMUNE SYSTEM ACC1 FAB FRAGMENT IN COMPLEX WITH CII583 - 591 (CG10) MOLECULE: SYNTHETIC PEPTIDE CONTAINING THE CII583 - 591 EPITOPE OF COLLAGEN TYPE II; ENGINEERED: YES; OTHER_DETAILS: THE SYNTHESIZED PEPTIDE IS A TRIPLE - HELICAL HOMOTRIMER OF THE ABOVE PROVIDED SEQUENCE, BUT ONLY A SINGLE ALPHA - CHAIN IS BOUND TO ACC1 IN THE CRYSTAL STRUCTURE ? ? MUS MUSCULUS 15 RASESVDNYGISSMN 7 AASKQGS 9 QQSKGVPYT 5 DAWMD 19 EIRNKVNNHATNYAESVKG 5 LTFDY crystal 2.70A 20.70% FAB 12-JAN-17 20170112 IMMUNE SYSTEM ACC1 FAB FRAGMENT IN COMPLEX WITH CITRULLINATED C1 EPITOPE OF CII (CG05) MOLECULE: TRIPLE - HELICAL PEPTIDE CONTAINING THE CITRULLINATED C1 EPITOPE OF COLLAGEN TYPE II,COLLAGEN ALPHA - 1 (II) CHAIN,TRIPLE - HELICAL PEPTIDE CONTAINING THE CITRULLINATED C1 EPITOPE OF COLLAGEN TYPE II; SYNONYM: ALPHA - 1 TYPE II COLLAGEN; ENGINEERED: YES; OTHER_DETAILS: THE SYNTHESIZED PEPTIDE IS HOMOTRIMERIC AND TRIPLE - HELICAL IN SOLUTION, BUT BOUND AS SINGLE ALPHA - CHAIN TO THE ACC1 FAB FRAGMENT; ? ? MUS MUSCULUS 15 RASESVDNYGISSMN 7 AASKQGS 9 QQSKGVPYT 5 DAWMD 19 EIRNKVNNHATNYAESVKG 5 LTFDY crystal 3.10A 23.30% FAB 13-JAN-17 20170113 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DC8E8 FAB AT PH 7.0 CONTAINING A ZN ATOM ? KAPPA ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 2.62A 21.60% FAB 13-JAN-17 20170113 IMMUNE SYSTEM ACC1 FAB FRAGMENT IN COMPLEX WITH CII583 - 591 (CG10) MOLECULE: SYNTHETIC PEPTIDE CONTAINING THE CII583 - 591 EPITOPE OF COLLAGEN TYPE II,COLLAGEN ALPHA - 1 (II) CHAIN,SYNTHETIC PEPTIDE CONTAINING THE CII583 - 591 EPITOPE OF COLLAGEN TYPE II,; SYNONYM: ALPHA - 1 TYPE II COLLAGEN,ALPHA - 1 TYPE II COLLAGEN,ALPHA - 1 TYPE II COLLAGEN; ENGINEERED: YES; OTHER_DETAILS: THE SYNTHESIZED PEPTIDE IS HOMOTRIMERIC AND TRIPLE - HELICAL IN SOLUTION, BUT BOUND AS SINGLE ALPHA CHAIN TO ACC1; ? ? MUS MUSCULUS 15 RASESVDNYGISSMN 7 AASKQGS 9 QQSKGVPYT 5 DAWMD 19 EIRNKVNNHATNYAESVKG 5 LTFDY crystal 2.95A 20.40% FAB 15-JAN-17 20170115 IMMUNE SYSTEM ACC1 FAB FRAGMENT IN COMPLEX WITH CITRULLINATED CII616 - 639 EPITOPE OF COLLAGEN TYPE II (PTM23) MOLECULE: SYNTHETIC PEPTIDE CONTAINING THE CITRULLINATED COLLAGEN TYPE II EPITOPE CII616 - 639,COLLAGEN ALPHA - 1 (II) CHAIN,SYNTHETIC PEPTIDE CONTAINING THE CITRULLINATED COLLAGEN TYPE II EPITOPE CII616 - 639; SYNONYM: ALPHA - 1 TYPE II COLLAGEN; ENGINEERED: YES; OTHER_DETAILS: THE SYNTHESIZED PEPTIDE IS (HOMO) TRIMERIC AND TRIPLE - HELICAL IN SOLUTION; ONE OF THE COMPONENT SINGLE CHAINS SHOULD CONTAIN THE "LYSINE KNOT" SEQUENCE EXTENSION KKYG TO PROMOTE CHEMICAL CROSSLINKING BETWEEN THE C - TERMINI OF THE THREE CHAINS; THEY ARE ALSO BIOTINYLATED FOR PURIFICATION PURPOSES ? ? MUS MUSCULUS 15 RASESVDNYGISSMN 7 AASKQGS 9 QQSKGVPYT 5 DAWMD 19 EIRNKVNNHATNYAESVKG 5 LTFDY crystal 2.90A 23.30% FAB 15-JAN-17 20170115 IMMUNE SYSTEM STRUCTURE OF DC8E8 FAB AT PH 6.5 CRYSTALLIZED IN SPACE - GROUP P1 ? KAPPA ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 2.50A 22.20% FAB 16-JAN-17 20170116 SIGNALING PROTEIN FAB 4AB007 BOUND TO INTERLEUKIN - 1 - BETA MOLECULE: INTERLEUKIN - 1 BETA; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 QQRSNWLWT 5 SYWIG 17 IIYPGDSDTRYSPSFQG 9 FVSLDAFDI crystal 2.15A 22.30% FAB 17-JAN-17 20170117 TRANSPORT PROTEIN STRUCTURE OF THE EAEC T6SS COMPONENT TSSK N - TERMINAL DOMAIN IN COMPLEX WITH LLAMA NANOBODIES NBK18 AND NBK27 MOLECULE: TYPE VI SECRETION PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YFTMA 16 TEISGGSANYADAVKG 12 RIWRGTVYDNIS crystal 2.20A 20.00% HC-dimer 18-JAN-17 20170118 IMMUNE SYSTEM STRUCTURE OF DC8E8 FAB CRYSTALLIZED AT PH 8.5 ? KAPPA ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 8 KQSFYLRT 5 DYVIS 17 EIFPRSGSTYYNEKFKG 11 DYYGTSFAMDY crystal 2.98A 22.00% FAB 20-JAN-17 20170120 IMMUNE SYSTEM STRUCTURE OF PYROGLUTAMATE - ABETA - SPECIFIC FAB C#17 IN COMPLEX WITH HUMAN ABETA - PE3 - 12PEGB MOLECULE: PYROGLUTAMATE - ABETA PE3 - 12 - PEGB; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSDGNTYLH 7 KVSNRFS 9 SQSTHVPPT 5 DYGMA 17 FISNLAYSIYYADTVTG 13 YDYDNILDYVMDY crystal 2.21A 18.90% FAB 25-JAN-17 20170125 TRANSFERASE CRYSTAL STRUCTURE OF A HER2 - NB COMPLEX MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN,MLN 19,PROTO - ONCOGENE NEU,PROTO - ONCOGENE C - ERBB - 2,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2,P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 SCGMG 16 RISGDGDTWHKESVKG 7 CYNLETY crystal 2.25A 18.70% HC-dimer 25-JAN-17 20170125 IMMUNE SYSTEM STRUCTURE OF PYROGLUTAMATE - ABETA - SPECIFIC FAB C#17 IN COMPLEX WITH MURINE ABETA - PE3 - 18PEGB MOLECULE: AMYLOID BETA A4 PROTEIN; SYNONYM: ABPP,APP,ALZHEIMER DISEASE AMYLOID A4 PROTEIN HOMOLOG, AMYLOID PRECURSOR PROTEIN,AMYLOIDOGENIC GLYCOPROTEIN,AG,BETA - AMYLOID PRECURSOR PROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSLVHSDGNTYLH 7 KVSNRFS 9 SQSTHVPPT 5 DYGMA 17 FISNLAYSIYYADTVTG 13 YDYDNILDYVMDY crystal 1.60A 17.50% FAB 26-JAN-17 20170126 IMMUNE SYSTEM STRUCTURE OF PYROGLUTAMATE - ABETA - SPECIFIC FAB C#6 IN COMPLEX WITH HUMAN ABETA - PE3 - 12 - PEGB MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: UNP RESIDUES 674 - 683; SYNONYM: ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AMYLOID PRECURSOR PROTEIN,BETA - AMYLOID PRECURSOR PROTEIN,CEREBRAL VASCULAR AMYLOID PEPTIDE,CVAP,PREA4,PROTEASE NEXIN - II,PN - II; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLYSDGKTYLN 7 LVSKLDS 9 VQGTHFPFT 5 GYTMN 17 LINPYNGVTRYNQKFKG 10 EAKREWDETY crystal 1.59A 18.00% FAB 27-JAN-17 20170127 IMMUNE SYSTEM STRUCTURE OF PYROGLUTAMATE - ABETA - SPECIFIC FAB C#24 IN COMPLEX WITH HUMAN ABETA - PE3 - 18 MOLECULE: PYROGLUTAMATE - ABETA PE3 - 18; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 VVSKLDS 9 VQGTHFPFT 5 NYWIN 17 QIYPGDGDTNYNGKFKG 6 EGYIVY crystal 1.49A 18.20% FAB 30-JAN-17 20170130 CYTOKINE IL - 23:IL - 23R:NB22E11 COMPLEX MOLECULE: INTERLEUKIN - 23 SUBUNIT ALPHA; SYNONYM: IL - 23 - A,INTERLEUKIN - 23 SUBUNIT P19,IL - 23P19; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 WSAVG 17 AIRWSGGSPYYADSVKD 14 TSLFPTSRGSHYDT crystal 2.80A 21.40% HC-dimer 01-FEB-17 20170201 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF L107C / A313C COVALENTLY LINKED DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN DIMER IN COMPLEX WITH THE FAB FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 MOLECULE: ENVELOPE GLYCOPROTEIN E; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: THE SPECIFIC STRAIN USED IN THIS WORK, FGA02, (WITHOUT ENGINEERED MUTATIONS) HAS BEEN SEQUENCED AND DEPOSITED PREVIOUSLY AND CORRESPONDS TO GENBANK: KM087965.1; ? ? HOMO SAPIENS 14 TGTSSNADTYNLVS 7 EGTKRPS 10 CSYATSRTLV 5 NHWMH 17 RINSDGSTRNYADFVKG 24 DGVRFYYDSTGYYPDSFFKYGMDV crystal 3.90A 30.60% FAB 02-FEB-17 20170202 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF A259C COVALENTLY LINKED DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN DIMER IN COMPLEX WITH THE FAB FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 MOLECULE: ENVELOPE GLYCOPROTEIN E; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: THE SOLUBLE ECTODOMAIN OF ENVELOPE GLYCOPROTEIN E IS MUTATED AT POSITION 259: ALA IS REPLACED BY CYS.; ? ? HOMO SAPIENS 14 TGTSSNADTYNLVS 7 EGTKRPS 10 CSYATSRTLV 5 NHWMH 17 RINSDGSTRNYADFVKG 24 DGVRFYYDSTGYYPDSFFKYGMDV crystal 3.90A 28.60% FAB 02-FEB-17 20170202 IMMUNE SYSTEM STRUCTURE OF UNBOUND BRIAKINUMAB FAB THE SECRETION SIGNAL IS CLEAVED OFF LIKELY BETWEEN RESIDUES 29 AND 30; ? ? HOMO SAPIENS 13 SGSRSNIGSNTVK 7 YNDQRPS 12 QSYDRYTHPALL 5 SYGMH 17 FIRYDGSNKYYADSVKG 6 HGSHDN crystal 2.22A 20.40% FAB 07-FEB-17 20170207 IMMUNE SYSTEM HUMAN FAB FRAGMENT 12E1 AGAINST NHBA FROM NEISSERIA MENINGITIDIS MOLECULE: LIGHT CHAIN; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQDLVYRDGITYLN 7 KVSNRDS 9 MQGTHWPIT 5 SHPIH 17 WINAGNGNTKYSQKFQD 6 ETKFDP crystal 2.75A 19.00% FAB 10-FEB-17 20170210 IMMUNE SYSTEM HUMAN FAB FRAGMENT 10C3 AGAINST NHBA FROM NEISSERIA MENINGITIDIS MOLECULE: LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGSYNRVS 7 EVSNRPS 10 SLYISSSTWV 5 NYGLH 17 WVSTNNGHTNYAQKVQG 6 GVDLDY crystal 1.50A 18.10% FAB 10-FEB-17 20170210 IMMUNE SYSTEM UNDERSTANDING THE SINGULAR CONFORMATIONAL LANDSCAPE OF THE TN ANTIGENS: SULFUR - FOR - OXYGEN SUBSTITUTION IN THE GLYCOSIDIC LINKAGE PROVIDES NEW INSIGHTS INTO MOLECULAR RECOGNITION BY AN ANTIBODY MOLECULE: APD (CG6) RP (NH2) PEPTIDE; ENGINEERED: YES LAMBDA ? MUS MUSCULUS 17 VASGFTFSNYWMNWVRQ 7 KSNNYAT 15 DTGIYYCTGVGQFAY 5 NYWMN 19 EIRLKSNNYATHYAESVKG 23 VGQFAYWGQGTTVTVSDIVVTQE crystal 1.70A 17.70% scFv 20-FEB-17 20170220 IMMUNE SYSTEM COMPUTATIONALLY DESIGNED FUNCTIONAL ANTIBODY MOLECULE: INTERLEUKIN - 17A; SYNONYM: IL - 17A,CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 8,CTLA - 8; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDIWWYLN 7 YTSRLHS 9 QQGFYLPWT 5 SYWIA 17 EILPGSGSTNYAQKFQG 10 FPYYYGNWDV crystal 1.96A 20.20% ? 21-FEB-17 20170221 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY BOUND TO VIRAL PROTEIN MOLECULE: PC4 AND SFRS1 - INTERACTING PROTEIN; SYNONYM: CLL - ASSOCIATED ANTIGEN KW - 7,DENSE FINE SPECKLES 70 KDA PROTEIN,DFS 70,LENS EPITHELIUM - DERIVED GROWTH FACTOR,TRANSCRIPTIONAL COACTIVATOR P75 / P52; ENGINEERED: YES; ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 TFSMN 17 YISRTSKTIYYADSVKG 18 GGWALGDEIPSSFLEFDY crystal 1.70A 19.10% HC-dimer 23-FEB-17 20170223 TRANSPORT PROTEIN PGLK FLIPPASE IN COMPLEX WITH INHIBITORY NANOBODY MOLECULE: WLAB PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMS 17 AITSGGGSTSYSDAVKG 14 GYVVDFLDLAEYDS crystal 3.90A 31.30% HC-dimer 01-MAR-17 20170301 HYDROLASE CRYSTAL STRUCTURE OF THE ARP4 - N - ACTIN (APO - STATE) HETERODIMER BOUND BY A NANOBODY MOLECULE: ACTIN - RELATED PROTEIN 4; SYNONYM: ACTIN - LIKE PROTEIN ARP4,ACTIN - LIKE PROTEIN 4; ENGINEERED: YES; OTHER_DETAILS: ACTIN - RELATED PROTEIN 4 ATP BOUND; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 NYGMG 17 AIGRFGFPLYYSDSVKG 15 RNPRATAEDVSAYDY crystal 2.80A 17.30% HC-dimer 02-MAR-17 20170302 HYDROLASE CRYSTAL STRUCTURE OF THE ARP4 - N - ACTIN (ATP - STATE) HETERODIMER BOUND BY A NANOBODY MOLECULE: ACTIN - RELATED PROTEIN 4; SYNONYM: ACTIN - LIKE PROTEIN ARP4,ACTIN - LIKE PROTEIN 4; ENGINEERED: YES; OTHER_DETAILS: ACTIN - RELATED PROTEIN 4 (ATP BOUND); ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 NYGMG 17 AIGRFGFPLYYSDSVKG 15 RNPRATAEDVSAYDY crystal 3.40A 15.40% HC-dimer 02-MAR-17 20170302 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT 22F12 IN COMPLEX WITH 3 - HYDROXYBENZO [A] PYRENE WITH 3 - HYDROXYBENZO [A] PYRENE ? ? MUS MUSCULUS 11 KASQDINSYLN 7 HTNRLVD 9 LQYDEFPYT 5 NYWIE 17 EILPGSGRINYNEKFKD 5 KYGDY crystal 2.40A 18.30% FAB 02-MAR-17 20170302 TRANSFERASE CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE - 2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM MOLECULE: ACTIVIN RECEPTOR TYPE - 2B; FRAGMENT: LIGAND BINDING DOMAIN; SYNONYM: ACTIVIN RECEPTOR TYPE IIB,ACTR - IIB; EC: 2.7.11.30; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGSYNYVN 7 GVSKRPS 11 GTFAGGSYYGV 5 SSYIN 17 TINPVSGSTSYAQKFQG 6 GGWFDY crystal 2.00A 17.80% FV 20-MAR-17 20170320 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE - 2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM MOLECULE: ACTIVIN RECEPTOR TYPE - 2B; FRAGMENT: VL, UNP RESIDUES 24 - 117; SYNONYM: ACTIVIN RECEPTOR TYPE IIB,ACTR - IIB; EC: 2.7.11.30; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGTSSDVGSYNYVN 7 GVSKRPS 11 GTFAGGSYYGV 5 SSYIN 17 TINPVSGSTSYAQKFQG 6 GGWFDY crystal 3.35A 21.60% FV 22-MAR-17 20170322 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BIMAGRUMAB FAB C - TERMINAL FLAG - HIS6 TAG; ? ? HOMO SAPIENS 14 TGTSSDVGSYNYVN 7 GVSKRPS 11 GTFAGGSYYGV 5 SSYIN 17 TINPVSGSTSYAQKFQG 6 GGWFDY crystal 1.78A 17.90% FAB 22-MAR-17 20170322 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 5D3 FAB ? ? ? MUS MUSCULUS 11 KASGYILNRLA 7 GATSLET 9 QQYWSTPWT 6 SDYAWN 16 YINFDGGTTYNPSLRG 10 FYGAKGTLDY crystal 1.50A 18.20% FAB 27-MAR-17 20170327 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE - ACTIVATED RECEPTOR - 2 (PAR2) IN TERNARY COMPLEX WITH FAB3949 AND AZ7188 AT 4.0 ANGSTROM RESOLUTION MOLECULE: PROTEINASE - ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562, PROTEINASE - ACTIVATED RECEPTOR 2; SYNONYM: PAR - 2,COAGULATION FACTOR II RECEPTOR - LIKE 1,G - PROTEIN COUPLED RECEPTOR 11,THROMBIN RECEPTOR - LIKE 1,CYTOCHROME B - 562,PAR - 2, COAGULATION FACTOR II RECEPTOR - LIKE 1,G - PROTEIN COUPLED RECEPTOR 11, THROMBIN RECEPTOR - LIKE 1; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 12 TASSSISSSYLH 7 STSNLAS 9 HQFHRSPYT 5 SYAMS 17 TISGIGSYTYYPDSVKG 10 QDYYGSSYDY crystal 4.00A 26.50% FAB 28-MAR-17 20170328 IMMUNE SYSTEM STRUCTURE OF INTERLEUKIN 23 IN COMPLEX WITH BRIAKINUMAB FAB MOLECULE: INTERLEUKIN - 23 SUBUNIT ALPHA; SYNONYM: IL - 23 - A,INTERLEUKIN - 23 SUBUNIT P19,IL - 23P19; ENGINEERED: YES; OTHER_DETAILS: FIRST 19 AMINO ACIDS FORM THE SIGNAL PEPTIDE. LAST 9 AMINO ACIDS ARE A CLONING SCAR AND PURIFICATION TAG.; ? ? HOMO SAPIENS 13 SGSRSNIGSNTVK 7 YNDQRPS 12 QSYDRYTHPALL 5 SYGMH 17 FIRYDGSNKYYADSVKG 6 HGSHDN crystal 3.90A 27.20% FAB 28-MAR-17 20170328 IMMUNE SYSTEM STRUCTURE OF NB36 CRYSTAL FORM 1 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAMG 16 AIYNSGRTNYVDSVKG 10 LGATTMSNAV crystal 1.19A 17.70% HC-dimer 05-APR-17 20170405 IMMUNE SYSTEM STRUCTURE OF NB36 CRYSTAL FORM 2 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAMG 16 AIYNSGRTNYVDSVKG 10 LGATTMSNAV crystal 1.50A 20.40% HC-dimer 05-APR-17 20170405 IMMUNE SYSTEM NB36 SER85CYS WITH HG, CRYSTAL FORM 1 MOLECULE: NB36; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAMG 16 AIYNSGRTNYVDSVKG 10 LGATTMSNAV crystal 1.50A 18.90% HC-dimer 05-APR-17 20170405 IMMUNE SYSTEM NB36 SER85CYS WITH HG BOUND MOLECULE: NANOBODY NB36 SER85CYS; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAMG 16 AIYNSGRTNYVDSVKG 10 LGATTMSNAV crystal 2.50A 23.90% HC-dimer 06-APR-17 20170406 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 2F22 FAB FRAGMENT AGAINST TFPI1 MOLECULE: TISSUE FACTOR PATHWAY INHIBITOR; SYNONYM: TFPI,EXTRINSIC PATHWAY INHIBITOR,EPI,LIPOPROTEIN - ASSOCIATED COAGULATION INHIBITOR,LACI; ENGINEERED: YES ? ? MUS 11 KASQSVGPAVA 7 SASNRYT 8 QQYTSYPT 5 NYGVH 16 VIWRGGSIDYNAAFMS 13 NSHGNYVGYAMDY crystal 1.65A 17.70% FAB 07-APR-17 20170407 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C VIRUS STRAIN J4 GLYCOPROTEIN E2 ANTIGENIC REGION 532 - 540 BOUND TO THE FAB FRAGMENT OF THE NON - NEUTRALIZING ANTIBODY DAO5 MOLECULE: GENOME POLYPROTEIN; FRAGMENT: UNP RESIDUES 529 - 540; ENGINEERED: YES; ? ? MUS MUSCULUS 11 CRASQGIYNYV 7 KYASQSI 10 CQQTNKWPLT 5 DFTFH 17 TIKPSNGDTAYNQKFKG 11 FGGSYPYAMDY crystal 1.70A 18.00% FAB 16-APR-17 20170416 VIRAL PROTEIN STRUCTURE OF THE HEPATITIS C VIRUS STRAIN J4 GLYCOPROTEIN E2 ANTIGENIC REGION 532 - 540 BOUND TO THE SINGLE CHAIN VARIABLE FRAGMENT OF THE NON - NEUTRALIZING ANTIBODY DAO5 MOLECULE: EPITOPE PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.00A 19.80% scFv 16-APR-17 20170416 VIRAL PROTEIN STRUCTURE OF THE HEPATITIS C VIRUS STRAIN JFH1 GLYCOPROTEIN E2 ANTIGENIC REGION 532 - 540 BOUND TO THE SINGLE CHAIN VARIABLE FRAGMENT OF THE NON - NEUTRALIZING ANTIBODY DAO5 MOLECULE: EPITOPE PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.90A 18.70% scFv 16-APR-17 20170416 IMMUNE SYSTEM IGE - FC IN COMPLEX WITH SINGLE DOMAIN ANTIBODY 026 MOLECULE: IMMUNOGLOBULIN HEAVY CONSTANT EPSILON; SYNONYM: IG EPSILON CHAIN C REGION,IG EPSILON CHAIN C REGION ND; ENGINEERED: YES; ? IGE LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 GNYDM 17 SSIDTGGDITHYADSVK 15 TDEEYALGPNEFDYY crystal 3.40A 21.50% HC-dimer 21-APR-17 20170421 IMMUNE SYSTEM HUMAN MONOCLONAL ANTIBODY WITH A LAIR1 INSERTION ? ? ? HOMO SAPIENS 11 RASQHINDSLA 7 GASNLHS 9 QQCNCFPPD 6 TNRRWS 16 EVHQSGRTNYNPSLKS 26 ASPLKSQRDTDLPRPSISAEPGTVIP crystal 2.52A 22.10% ? 26-APR-17 20170426 IMMUNE SYSTEM JUNIN VIRUS GP1 GLYCOPROTEIN IN COMPLEX WITH AN ANTIBODY FAB FRAGMENT MOLECULE: PRE - GLYCOPROTEIN POLYPROTEIN GP COMPLEX; FRAGMENT: RECEPTOR ATTACHMENT GLYCOPROTEIN GP1; ENGINEERED: YES; OTHER_DETAILS: FRAGMENT: RECEPTOR ATTACHMENT GLYCOPROTEIN GP1, RESIDUES 87 - 232 ? ? MUS MUSCULUS 15 CRASESVDDYGISFM 7 YTASSQG 10 CQQSKEVPYT 5 SYWMH 17 AIYPGDSDTKYNQKFKG 11 RNTLTGDYFDY crystal 1.85A 18.60% FAB 03-MAY-17 20170503 IMMUNE SYSTEM HUMAN FAB FRAGMENT 5H2 AGAINST NHBA FROM NEISSERIA MENINGITIDIS ? ? ? HOMO SAPIENS 11 RASQSISNYLN 7 AASSLGS 8 QQSYGSPT 7 SGSSYWT 16 YTSYSGSTKYNPSLKS 13 DRFDVASGSSFDF crystal 1.88A 18.80% FAB 12-MAY-17 20170512 VIRAL PROTEIN GII.17 KAWASAKI323 PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO - 4 MOLECULE: CAPSID PROTEIN; FRAGMENT: UNP RESIDUES 225 - 528; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 SYAMR 19 VAAITSAGGSTHYADSVKE 15 RRDYGDSWFTAGGGY crystal 1.72A 15.20% HC-dimer 16-MAY-17 20170516 VIRAL PROTEIN GII.10 VIETNAM 026 PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO - 32 MOLECULE: CAPSID PROTEIN; ENGINEERED: YES; ? ? NOROVIRUS 0 N/A 0 N/A 0 N/A 5 YYPIG 17 CISGSGGSANYAASVKG 23 DLSSLQAMCVIPRPGFSAKAYDY crystal 2.19A 17.30% HC-dimer 16-MAY-17 20170516 VIRAL PROTEIN GII.10 VIETNAM 026 NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO - 26 AND NANO - 85 MOLECULE: CAPSID PROTEIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 IYAMG 14 SSGGGTNYADSVKG 26 EDYSAYAPPSGSRGRGTQVTVSSHHH crystal 2.30A 21.30% HC-dimer 16-MAY-17 20170516 VIRAL PROTEIN GII.10 VIETNAM 026 NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO - 42 MOLECULE: CAPSID PROTEIN; ENGINEERED: YES ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 TYVMG 16 TITSVGSTNYADSLKG 12 IRYSPIHAPLDY crystal 2.00A 18.20% HC-dimer 16-MAY-17 20170516 LYASE CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN NB474 AND TRYPANOSOMA CONGOLENSE FRUCTOSE - 1,6 - BISPHOSPHATE ALDOLASE MOLECULE: FRUCTOSE - BISPHOSPHATE ALDOLASE; EC: 4.1.2.13; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 7 YYAIGWF 19 SRINSGSGARTDYADSVKG 24 DTTDRYDSANGRYYCTISSDTYDY crystal 2.57A 19.40% HC-dimer 17-MAY-17 20170517 IMMUNE SYSTEM CO - CRYSTAL STRUCTURE OF A CROSS - REACTIVE BACTERICIDAL HUMAN ANTIBODY TARGETING MENINGOCOCCAL VACCINE ANTIGEN FACTOR H BINDING PROTEIN MOLECULE: FACTOR H BINDING PROTEIN VARIANT 1.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISVSLN 7 AASRLQS 10 QETYSDLMYT 5 NYWVV 17 SIHPRDSDARYSLSFEG 13 LSQVSGWSPWVGP crystal 2.20A 19.40% FAB 18-MAY-17 20170518 IMMUNE SYSTEM HUMAN FAB 5H2 BOUND TO NHBA - C3 FROM NEISSERIA MENINGITIDIS SEROGROUP B MOLECULE: GNA2132; SYNONYM: GNA2132,HEPARIN BINDING PROTEIN,NEISSERIAL HEPARIN BINDING ANTIGEN,PUTATIVE LIPOPROTEIN GNA2132; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISNYLN 7 AASSLGS 8 QQSYGSPT 7 SGSSYWT 16 YTSYSGSTKYNPSLKS 13 DRFDVASGSSFDF crystal 2.86A 18.00% FAB 19-MAY-17 20170519 VIRUS LLAMA VHH IN COMPLEX WITH P24 MOLECULE: CAPSID PROTEIN P24; ENGINEERED: YES; OTHER_DETAILS: THE FOLLOWING REAGENT WAS OBTAINED THROUGH THE NIH AIDS REAGENT PROGRAM, DIVISION OF AIDS, NIAID, NIH: PWISP98 - 85 FROM DR. WES SUNDQUIST.; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 FNAMG 16 RIVKGFDPVLADSVKG 6 ALDTAY crystal 2.76A 22.40% HC-dimer 22-MAY-17 20170522 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VEGF IN COMPLEX WITH HETERODIMERIC FCAB JANUSCT6 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293-6E; EXPRESSION_SYSTEM_ORGAN: KIDNEY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 4; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: VEGFA, VEGF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.15A 20.10% FC 29-MAY-17 20170529 ONCOPROTEIN HER2 IN COMPLEX WITH FAB MF3958 MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; FRAGMENT: UNP RESIDUES 23 - 628; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN,MLN 19,PROTO - ONCOGENE NEU,PROTO - ONCOGENE C - ERBB - 2,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2,P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPPT 5 AYYIN 17 RIYPGSGYTSYAQKFQG 12 PPVYYDSAWFAY crystal 3.00A 23.10% FAB 29-MAY-17 20170529 IMMUNE SYSTEM HER3 IN COMPLEX WITH FAB MF3178 MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 3; SYNONYM: PROTO - ONCOGENE - LIKE PROTEIN C - ERBB - 3,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER3; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPPT 5 GYYMH 17 WINPNSGGTNYAQKFQG 15 DHGSRHFWSYWGFDY crystal 3.40A 21.70% FAB 30-MAY-17 20170530 VIRUS THE CRYO - EM STRUCTURE OF TICK - BORNE ENCEPHALITIS VIRUS COMPLEXED WITH FAB FRAGMENT OF NEUTRALIZING ANTIBODY 19 / 1786 MOLECULE: GENOME POLYPROTEIN; EC: 3.4.21.91,3.6.1.15,3.6.4.13,2.1.1.56,2.1.1.57,2.7.7.48; ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRYS 9 QQYNNHPLT 5 SYGMS 17 ATNSDGDSTYYPDSVKG 11 VLYDYDGEFAY ElectronMicroscopy N/A N/A FAB 07-JUN-17 20170607 IMMUNE SYSTEM HER3 IN COMPLEX WITH FAB MF3178 MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 3; SYNONYM: PROTO - ONCOGENE - LIKE PROTEIN C - ERBB - 3,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER3; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPPT 5 GYYMH 17 WINPNSGGTNYAQKFQG 15 DHGSRHFWSYWGFDY crystal 4.50A 25.00% FAB 09-JUN-17 20170609 MEMBRANE PROTEIN STRUCTURE OF A CHIMAERIC BETA3 - ALPHA5 GABAA RECEPTOR IN COMPLEX WITH NANOBODY NB25 AND PREGNANOLONE MOLECULE: GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA - 3,GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA - 5,GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA - 5; SYNONYM: GABA (A) RECEPTOR SUBUNIT BETA - 3,GABA (A) RECEPTOR SUBUNIT ALPHA - 5,GABA (A) RECEPTOR SUBUNIT ALPHA - 5; ENGINEERED: YES; OTHER_DETAILS: THIS IS A CHIMAERIC CONSTRUCT, CONTAINING THE SECRETION SIGNAL SEQUENCE FROM PHLSEC VECTOR (PMID: 17001101) , THE EXTRACELLULAR REGION OF HUMAN GBRB3 (MATURE POLYPEPTIDE RESIDUES 1 - 217 FROM UNIPROT P28472) , THE TRANSMEMBRANE REGION FROM HUMAN GBRA5 (MATURE POLYPEPTIDE RESIDUES 226 - 431 FROM UNIPROT P31644 WITH THE EXCEPTION OF THE M3 - M4 LOOP, RESIDUES 316 - 392, WHICH WERE SUBSTITUTED BY SQPARAA) AND A C - TERMINAL RHO - 1D4 PURIFICATION TAG (TETSQVAPA) .; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YPIMG 17 AISWSGGSTSYADSVKD 16 KGRYSGGLYYPTNYDY crystal 3.20A 23.30% HC-dimer 13-JUN-17 20170613 IMMUNE SYSTEM FAB COMPLEX WITH GROBETA. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION - MAKING IN ANTIBODY DRUG DISCOVERY. MOLECULE: C - X - C MOTIF CHEMOKINE 2; SYNONYM: GROWTH - REGULATED PROTEIN BETA,GRO - BETA,MACROPHAGE INFLAMMATORY PROTEIN 2 - ALPHA,MIP2 - ALPHA; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIESYLS 7 YATRLAD 9 LQHGESPPT 5 NYWIV 17 DLYSGGGYTFYSENFKG 10 SGYDRTWFAH crystal 1.65A 16.90% FAB 26-JUN-17 20170626 IMMUNE SYSTEM FAB. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION - MAKING IN ANTIBODY DRUG DISCOVERY. ? ? ? MUS MUSCULUS 16 RSSKSLLHRNGITYLY 7 QMSNLAS 8 AQNLELWT 5 VYYVH 17 RIDPENGETIYTPKFQD 3 SGY crystal 1.92A 17.50% FAB 26-JUN-17 20170626 HYDROLASE PCSK9:FAB COMPLEX WITH DEXTRAN SULFATE MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1,NARC - 1,PROPROTEIN CONVERTASE 9,PC9,SUBTILISIN / KEXIN - LIKE PROTEASE PC9; EC: 3.4.21. -; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GNSNRPS 11 QSYDSSLSGSV 5 SYSMN 17 SISSSSSYISYADSVKG 14 DYDFWSAYYDAFDV crystal 2.30A 16.90% FAB 30-JUN-17 20170630 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CD32B (FC GAMMA RECEPTOR IIB) IN COMPLEX WITH HUMAN IGG1 FAB FRAGMENT (6G08) MOLECULE: LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II - B; SYNONYM: IGG FC RECEPTOR II - B,CDW32,FC - GAMMA RII - B,FCRII - B; ENGINEERED: YES; OTHER_DETAILS: CRYSTAL STRUCTURE DOES NOT RESOLVE RESIDUES 1 - 10, 32 - 36. RESIDUE 44 MODELLED AS ALA DUE TO LACK OF DENSITY.; ? IGG1 HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GDTNRPS 11 AAWDDSLNGPV 5 SYGIS 17 GISGSGGNTYYADSVKG 12 SVGAYANDAFDI crystal 2.50A 19.60% FAB 30-JUN-17 20170630 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ACPA E4 IN COMPLEX WITH CEP1 MOLECULE: CEP1 PEPTIDE (FROM ENOLASE); ENGINEERED: YES; OTHER_DETAILS: BIOTIN IS ATTACHED TO THE AMINOHEXANOIC ACID AT THE N - TERMINUS GLU7 AND ILE8 NOT MODELED DUE TO POOR DEFINITION IN ELECTRON DENSITY ? ? HOMO SAPIENS 13 SGDDSILRSAFVS 7 DDRQRPS 11 AAWNGRLSAFV 6 ESYFWG 16 SVIHTGTTYYRPSLES 11 IRGGSSNWLDP crystal 1.60A 18.50% FAB 03-JUL-17 20170703 IMMUNE SYSTEM NANOBODY - ANTI - VGLUT NANOBODY COMPLEX MOLECULE: ANTI - LLAMA NANOBODY; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 TWSIYGM 17 FVAGITWRGGNTHYADF 18 CAANPNPSGSSVYRRNDY crystal 2.20A 18.90% HC-dimer 03-JUL-17 20170703 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ACPA E4 IN COMPLEX WITH CII - C - 13 - CIT MOLECULE: CII - C - 13 - CIT; ENGINEERED: YES; OTHER_DETAILS: CITRULLINATED EPITOPE DERIVED FROM HUMAN COLLAGEN TYPE II BIOTIN AND AMINOHEXANOIC ACID ATTACHED AT N - TERMINUS CIRCULARIZED VIA DISULFIDE BRIDGE FORMATION BETWEEN THE TWO CYSTEINES UNMODELLED RESIDUES NOT VISIBLE IN ELECTRON DENSITY MAP ? IGG2 HOMO SAPIENS 13 SGDDSILRSAFVS 7 DDRQRPS 11 AAWNGRLSAFV 6 ESYFWG 16 SVIHTGTTYYRPSLES 11 IRGGSSNWLDP crystal 1.75A 17.80% FAB 04-JUL-17 20170704 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ACPA E4 IN COMPLEX WITH CII - C - 48 - CIT MOLECULE: CII - C - 48 - CIT; ENGINEERED: YES; OTHER_DETAILS: SYNTHETIC PEPTIDE CONTAINING A CITRULLINATED COLLAGEN TYPE II EPITOPE BIOTIN AND AMINOHEXANOIC ACID ATTACHED AT N - TERMINUS CIRCULARIZED VIA DISULFIDE BRIDGE FORMATION BETWEEN THE TWO CYSTEINES ? IGG2 HOMO SAPIENS 13 SGDDSILRSAFVS 7 DDRQRPS 11 AAWNGRLSAFV 6 ESYFWG 16 SVIHTGTTYYRPSLES 11 IRGGSSNWLDP crystal 2.60A 19.00% FAB 04-JUL-17 20170704 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ACPA E4 ? ? IGG2 HOMO SAPIENS 13 SGDDSILRSAFVS 7 DDRQRPS 11 AAWNGRLSAFV 6 ESYFWG 16 SVIHTGTTYYRPSLES 11 IRGGSSNWLDP crystal 1.80A 17.20% FAB 04-JUL-17 20170704 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RA - ASSOCIATED MAB B2 (FAB FRAGMENT) ? ? ? HOMO SAPIENS 11 RASQSISSWLA 7 SASSLQS 9 QQANSFPFT 5 NYVIS 17 GIIPIFGTAHYAQKFQG 18 INTSPILTGYYFPGVHDY crystal 2.20A 20.20% FAB 05-JUL-17 20170705 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RA - ASSOCIATED MAB D10 (CHIMERIC FAB FRAGMENT) ? LAMBDA IGG2 HOMO SAPIENS 11 SGDKLGDKYAC 7 QHSKRPS 9 QAWDSSTVV 5 SYDMH 17 VISYDGSNKYYADSVKG 15 VRGAAATGYYYGMDV crystal 1.53A 18.90% FAB 05-JUL-17 20170705 VIRAL PROTEIN COMPLEX OF A BINDING PROTEIN AND HUMAN ADENOVIRUS C 5 HEXON MOLECULE: HEXON PROTEIN; SYNONYM: CP - H,PROTEIN II; ? ? MUS MUSCULUS 17 GDRVTITCKASQSVTND 7 KAPKLLI 15 EDFATYFCHQDYSSP 7 TCKASQS 16 APKLLIYQASTRYTGV 26 DYSSPLTFGQGTKVEIKRQVQLVQSG crystal 2.80A 20.00% scFv 13-JUL-17 20170713 MEMBRANE PROTEIN STRUCTURE OF A CHIMAERIC BETA3 - ALPHA5 GABAA RECEPTOR IN COMPLEX WITH NANOBODY NB25 MOLECULE: HUMAN GABAA RECEPTOR CHIMERA BETA3 - ALPHA5,GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA - 3,GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA - 5; SYNONYM: GABA (A) RECEPTOR SUBUNIT BETA - 3,GABA (A) RECEPTOR SUBUNIT ALPHA - 5; ENGINEERED: YES; OTHER_DETAILS: THIS IS A CHIMAERIC CONSTRUCT, CONTAINING THE SECRETION SIGNAL SEQUENCE FROM PHLSEC VECTOR (PMID: 17001101) , THE EXTRACELLULAR REGION OF H UMAN GBRB3 (MATURE POLYPEPTIDE RESIDUES 1 - 217 FROM UNIPROT P28472) , THE TRANSMEMBRANE REGION FROM HUMAN GBRA5 (MATURE POLYPEPTIDE RESIDUES 226 - 431 FROM UNIPROT P31644 WITH THE EXCEPTION OF THE M3 - M4 LOOP, RESIDUES 316 - 392, WHICH WERE SUBSTITUTED BY SQPARAA) AND A C - TERMINAL R HO - 1D4 PURIFICATION TAG (TETSQVAPA) .; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YPIMG 17 AISWSGGSTSYADSVKD 16 KGRYSGGLYYPTNYDY crystal 3.30A 23.40% HC-dimer 21-JUL-17 20170721 VIRAL PROTEIN GII.10 VIETNAM 026 PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO - 14 MOLECULE: CAPSID PROTEIN; FRAGMENT: PROTRUDING DOMAIN, UNP RESIDUES 224 - 538; SYNONYM: GII.10 PROTRUDING DOMAIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 0 15 ITDDGSTDYVDSVKG 10 IVVFTTPMHY crystal 1.70A 16.60% HC-dimer 01-AUG-17 20170801 VIRAL PROTEIN GII.10 VIETNAM 026 PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO - 27 MOLECULE: CAPSID PROTEIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 RNIMG 16 SIYSDRSTWYAESVEG 5 RTLGS crystal 2.68A 23.60% HC-dimer 01-AUG-17 20170801 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - ALPHAVBETA3 INTEGRIN FAB LM609 ? ? ? MUS MUSCULUS 11 RASQSISNHLH 7 YASQSIS 9 QQSNSWPHT 5 SYDMS 17 KVSSGGGSTYYLDTVQG 8 HNYGSFAY crystal 2.26A 21.50% FAB 10-AUG-17 20170810 IMMUNE SYSTEM MONOMERIC POLCALCIN (PHL P 7) IN COMPLEX WITH TWO IDENTICAL ALLERGEN - SPECIFIC ANTIBODIES MOLECULE: POLCALCIN PHL P 7; SYNONYM: CALCIUM - BINDING POLLEN ALLERGEN PHL P 7,P7; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGGSSNFGAGYDVH 7 GNNNRPS 11 QSFDTSLSGWI 5 SYAIH 17 RINTDNGNTKYSQKFHG 12 AFYYSSGVMFDS crystal 2.35A 20.10% FAB 22-AUG-17 20170822 TRANSPORT PROTEIN NANOBODY - BOUND BTUF, THE VITAMIN B12 BINDING PROTEIN IN ESCHERICHIA COLI MOLECULE: VITAMIN B12 - BINDING PROTEIN; ENGINEERED: YES; OTHER_DETAILS: OMPA - BTUF - 3C - HIS6; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DYAIG 17 CIGSSGDSTNYADSVKG 18 AHRIFGGCLVIHSSGYVS crystal 2.65A 22.50% HC-dimer 30-AUG-17 20170830 TOXIN RTA1 - 33 / 44 - 198 (RVEC) BOUND TO SINGLE DOMAIN ANTIBODY A3C8 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; ORGANISM_SCIENTIFIC: RICINUS COMMUNIS; ORGANISM_COMMON: CASTOR BEAN; ORGANISM_TAXID: 3988; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.73A 22.80% SDAB 04-AUG-16 20160804 TOXIN ANTI - RICIN A - CHAIN SINGLE DOMAIN ANTIBODY A3C8 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 0 0 0 0 0 crystal 2.70A 20.10% SDAB 04-AUG-16 20160804 TRANSFERASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF PANITUMUMAB IN COMPLEX WITH EPIDERMAL GROWTH FACTOR RECEPTOR DOMAIN 3. MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: UNP RESIDUES 335 - 525; SYNONYM: PROTO - ONCOGENE C - ERBB - 1,RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDISNYLN 7 DASNLET 9 QHFDHLPLA 7 SGDYYWT 16 HIYYSGNTNYNPSLKS 9 DRVTGAFDI crystal 2.80A 22.60% FAB 09-AUG-16 20160809 TRANSFERASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF PANITUMUMAB IN COMPLEX WITH EPIDERMAL GROWTH FACTOR RECEPTOR DOMAIN 3 MUTANT S468R. MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: UNP RESIDUES 335 - 528; SYNONYM: PROTO - ONCOGENE C - ERBB - 1,RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES ? ? HOMO SAPIENS 11 QASQDISNYLN 7 DASNLET 9 QHFDHLPLA 7 SGDYYWT 16 HIYYSGNTNYNPSLKS 9 DRVTGAFDI crystal 2.50A 22.70% FAB 09-AUG-16 20160809 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX OF 10E8 FAB LIGHT CHAIN MUTANT1 AND T117V2 HIV - 1 MPER SCAFFOLD MOLECULE: 10E8 EPITOPE SCAFFOLD T117V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 QGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 1.62A 17.40% FAB 10-AUG-16 20160810 IMMUNE SYSTEM 2A10 FAB FRAGMENT 2.54 ANGSTOMS ? ? ? HOMO SAPIENS 11 SASQGISNYLN 7 YTSTLYS 9 QQYSRFPYV 5 NYGIN 17 WINTITEEPTFAEEFTG 9 GSEFGRLVY crystal 2.52A 22.60% FAB 13-AUG-16 20160813 IMMUNE SYSTEM 2A10 ANTIBODY FAB FRAGMENT ? ? ? MUS MUSCULUS 11 SASQGISNYLN 7 YTSTLYS 9 QQYSRFPYV 5 NYGIN 17 WINTITEEPTFAEEFTG 9 GSEFGRLVY crystal 3.01A 22.60% FAB 17-AUG-16 20160817 VIRAL PROTEIN CRYSTAL STRUCTURE OF EBV GHGL / GP42 / E1D1 COMPLEX MOLECULE: ENVELOPE GLYCOPROTEIN L; SYNONYM: GL; ENGINEERED: YES; ? IGG2 MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 9 SQSIHVPRT 5 DYVIS 17 EIYPESGNTYYNEKFKG 6 GYAMDF crystal 3.10A 21.40% ? 18-AUG-16 20160818 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH CQFDA (PH) 2STRRLKC MOLECULE: CQFDA (PH) 2STRRLKC PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 16.30% FAB 19-AUG-16 20160819 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH CQA (PH) 2DLSTRRLKC PEPTIDE MOLECULE: CYCLIC MEDITOPE CQA (PH) 2DLSTRRLKC; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 16.00% FAB 19-AUG-16 20160819 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH CQYDLSTRRLKC MOLECULE: CYCLIC PEPTIDE CQYDLSTRRLKC; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.53A 15.60% FAB 19-AUG-16 20160819 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB LIGHT CHAIN MUTANT3, AGAINST THE MPER REGION OF THE HIV - 1 ENV, IN COMPLEX WITH THE MPER EPITOPE SCAFFOLD T117V2 MOLECULE: 10E8 EPITOPE SCAFFOLD T117V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 EGDSLESHYAS 7 GDDNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.03A 17.60% FAB 23-AUG-16 20160823 IMMUNE SYSTEM CRYSTAL STRUCTURE OF STRAIN - SPECIFIC GLYCAN - DEPENDENT CD4 BINDING SITE - DIRECTED NEUTRALIZING ANTIBODY CAP257 - RH1, IN COMPLEX WITH HIV - 1 STRAIN RHPA GP120 CORE WITH AN OLIGOMANNOSE N276 GLYCAN. MOLECULE: RHPA GP120 CORE; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDTLSTKWSY 7 EGNKRFS 11 FSTDSSGQTWV 5 EKAMH 17 IIWYNSIHKNYADSVKG 11 AGGGKYDYLDV crystal 3.21A 23.10% ? 24-AUG-16 20160824 IMMUNE SYSTEM HIV GP140 TRIMER MD39 - 10MUTA IN COMPLEX WITH FABS PGT124 AND 35022 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 4.50A 27.20% FAB 26-AUG-16 20160826 IMMUNE SYSTEM STRUCTURE OF THE ANTI - HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 WITH FREE MAN9 GLYCAN ? ? ? MACACA MULATTA 13 AGTKSNIGDCSVS 7 QNNNRPS 11 LSYDTSFSGWR 7 SSDTAVV 16 AIYWDDVEHINPSLKS 15 VRFVSGGYYTDRIDS crystal 1.99A 18.90% FAB 30-AUG-16 20160830 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX OF 10E8 FAB LIGHT CHAIN MUTANT5 AND T117V2 HIV - 1 MPER SCAFFOLD MOLECULE: 10E8 EPITOPE SCAFFOLD T117V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLASHAAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.07A 18.00% FAB 30-AUG-16 20160830 PROTEIN BINDING NEISSERIA MENINGITIDIS FACTOR H BINDING PROTEIN IN COMPLEX WITH MONOCLONAL ANTIBODY JAR5 MOLECULE: FACTOR H BINDING PROTEIN VARIANT B24; SYNONYM: FACTOR H BINDING PROTEIN VARIANT B24_001,FACTOR H BINDING PROTEIN VARIANT B24_002,FACTOR H BINDING PROTEIN VARIANT B24_004, FACTOR H BINDING PROTEIN VARIANT B24_005,FACTOR H BINDING PROTEIN VARIANT B24_006,FACTOR H BINDING PROTEIN VARIANT B24_007,FACTOR H BINDING PROTEIN VARIANT B24_008,FACTOR H BINDING PROTEIN VARIANT B24_010,PUTATIVE LIPOPROTEIN; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLF 7 RMSNLAS 9 MQHLEYPYT 5 SYWMH 17 RIAPDTGIIYYNEKFKN 13 YLKYDGSTYRFDY crystal 2.98A 22.50% ? 30-AUG-16 20160830 MEMBRANE PROTEIN CALCIUM - ACTIVATED CHLORIDE CHANNEL BESTROPHIN - 1 (BEST1) , TRIPLE MUTANT: I76A, F80A, F84A; IN COMPLEX WITH AN FAB ANTIBODY FRAGMENT, CHLORIDE, AND CALCIUM MOLECULE: BESTROPHIN - 1 (BEST1); ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASENIYSYLT 7 NAKTLTE 9 QHHYGTPPT 5 NYWMH 17 MIDPSKSETTLNQKFRG 7 EVYYFDY crystal 3.10A 21.80% FAB 31-AUG-16 20160831 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB IN COMPLEX WITH THE MPER EPITOPE SCAFFOLD T117V2 MOLECULE: 10E8 EPITOPE SCAFFOLD T117V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.10A 18.00% FAB 01-SEP-16 20160901 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THERAPEUTIC MAB AR20.5 IN COMPLEX WITH MUC1 PEPTIDE MOLECULE: MUC1 PEPTIDE FRAGMENT; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQTIVHSNGKIYLE 7 RVSKRFS 9 FQGSHVPWT 5 SYPMS 17 YINNGGGNPYYPDTVKG 7 QYYGFDY crystal 1.97A 22.30% FAB 01-SEP-16 20160901 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THERAPEUTIC MAB AR20.5 IN COMPLEX WITH MUC1 PEPTIDE MOLECULE: MUC1 GLYCOPEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQTIVHSNGKIYLE 7 RVSKRFS 9 FQGSHVPWT 5 SYPMS 17 YINNGGGNPYYPDTVKG 7 QYYGFDY crystal 2.20A 19.50% ? 02-SEP-16 20160902 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB IN COMPLEX WITH THE MPER EPITOPE SCAFFOLD T117V2 AND PHOSPHATIDIC ACID (06:0 PA) MOLECULE: 10E8 EPITOPE SCAFFOLD T117V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.62A 18.70% FAB 06-SEP-16 20160906 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB IN COMPLEX WITH THE MPER EPITOPE SCAFFOLD T117V2 AND PHOSPHATIDYLGLYCEROL (06:0 PG) MOLECULE: 10E8 EPITOPE SCAFFOLD T117V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.37A 19.80% FAB 06-SEP-16 20160906 IMMUNE SYSTEM IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN AL - T05 LAST RESIDUE WAS NOT VISIBLE ON ELECTRON DENSITY ? ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 11 GTWDSSLSALV 0 N/A 0 N/A 0 N/A crystal 1.90A 17.20% LC-dimer 09-SEP-16 20160909 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MSP2 FV FRAGMENT (MAB4D11) IN COMPLEX WITH 3D7 - MSP2 215 - 222 MOLECULE: MEROZOITE SURFACE PROTEIN 2; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLHSNGKTYLN 7 LVSKLDS 9 WQGTHFPIT 5 DDYMH 17 RIDPANGNTQYAPKFQD 5 GGLLR crystal 2.20A 20.90% FV 12-SEP-16 20160912 REPLICATION CRYSTAL STRUCTURE OF AN EXTENDED DWARF NDC80 COMPLEX MOLECULE: KINETOCHORE PROTEIN NUF2; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 0 13 SINAVGLVRNVLG 6 RYYYDY crystal 7.53A 31.30% HC-dimer 17-SEP-16 20160917 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - HER2 ANTIBODY 4D5 WITH REDESIGNED HEAVY AND LIGHT CHAIN INTERFACES ? ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLES 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 5 WAMDY crystal 1.63A 18.70% FAB 19-SEP-16 20160919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - HER2 ANTIBODY 4D5 WITH REDESIGNED HEAVY AND LIGHT CHAIN INTERFACES ? ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLES 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 5 WAMDY crystal 1.61A 23.80% FAB 19-SEP-16 20160919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - HER2 ANTIBODY 4D5 WITH REDESIGNED HEAVY AND LIGHT CHAIN INTERFACES ? ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLES 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 5 WAMDY crystal 1.72A 22.20% FAB 19-SEP-16 20160919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VRC01 - CLASS ANTIBODY N6 IN COMPLEX WITH HIV - 1 CLADE G STRAIN X2088 GP120 CORE MOLECULE: HIV - 1 CLADE G STRAIN X2088 GP120; ENGINEERED: YES; OTHER_DETAILS: EXTENDED CORE PORTION OF HIV - 1 GP120; ? ? HOMO SAPIENS 11 QTSQGVGSDLH 7 HTSSVED 5 QVLQF 5 AHILF 17 WIKPQYGAVNFGGGFRD 13 DRSYGDSSWALDA crystal 2.75A 21.10% ? 20-SEP-16 20160920 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VRC01 - CLASS ANTIBODY N6 IN COMPLEX WITH HIV - 1 CLADE AE STRAIN 93TH057 GP120 CORE MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QTSQGVGSDLH 7 HTSSVED 5 QVLQF 5 AHILF 17 WIKPQYGAVNFGGGFRD 13 DRSYGDSSWALDA crystal 2.40A 22.90% ? 20-SEP-16 20160920 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING VRC01 - CLASS ANTIBODY N6 IN COMPLEX WITH HIV - 1 CLADE C STRAIN DU172.17 GP120 CORE MOLECULE: HIV - 1 GP120 CORE; ENGINEERED: YES ? ? HOMO SAPIENS 11 QTSQGVGSDLH 7 HTSSVED 5 QVLQF 5 AHILF 17 WIKPQYGAVNFGGGFRD 13 DRSYGDSSWALDA crystal 2.15A 19.10% ? 20-SEP-16 20160920 IMMUNE SYSTEM STRUCTURE OF CHIMERIC 02 - CC FAB, A VRC01 - LIKE GERMLINE ANTIBODY ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNGGDTNYAQKFQG 10 EYSSGWYFAY crystal 1.86A 21.10% FAB 23-SEP-16 20160923 IMMUNE SYSTEM STRUCTURE OF CHIMERIC 02 - K FAB, A VRC01 - LIKE GERMLINE ANTIBODY ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 8 GWGWYFDL crystal 2.32A 20.30% FAB 26-SEP-16 20160926 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8 FAB LIGHT CHAIN MUTANT2 AGAINST THE MPER REGION OF THE HIV - 1 ENV, IN COMPLEX WITH T117V2 EPITOPE SCAFFOLD MOLECULE: 10E8 EPITOPE SCAFFOLD T117V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 EGDSLESHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAAPVEG 20 TGKYYDFWSGYPPGEEYFQD crystal 2.17A 17.20% FAB 26-SEP-16 20160926 IMMUNE SYSTEM STRUCTURE OF CHIMERIC 02 - CB FAB, A VRC01 - LIKE GERMLINE ANTIBODY ? ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYAQKFQG 12 DGWYSSGWYFDS crystal 2.74A 25.10% FAB 27-SEP-16 20160927 IMMUNE SYSTEM CETUXIMAB FAB IN COMPLEX WITH L5Q MEDITOPE VARIANT MOLECULE: L5Q MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 1.84A 16.20% FAB 28-SEP-16 20160928 HYDROLASE / HYDROLASE INHIBITOR STRUCTURE DETERMINATION OF A POTENT, SELECTIVE ANTIBODY INHIBITOR OF HUMAN MMP9 (GS - 5745 BOUND TO MMP - 9) MOLECULE: MATRIX METALLOPROTEINASE - 9,MATRIX METALLOPROTEINASE - 9; SYNONYM: MMP - 9,92 KDA GELATINASE,92 KDA TYPE IV COLLAGENASE, GELATINASE B,GELB,MMP - 9,92 KDA GELATINASE,92 KDA TYPE IV COLLAGENASE, GELATINASE B,GELB; EC: 3.4.24.35,3.4.24.35; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 11 KASQDVRNTVA 7 SSSYRNT 9 QQHYITPYT 5 SYGVH 16 VIWTGGTTNYNSALMS 7 YYYGMDY crystal 3.00A 21.90% FAB 29-SEP-16 20160929 VIRAL PROTEIN CRYO - EM STRUCTURE OF A BG505 ENV - SCD4 - 17B - 8ANC195 COMPLEX MOLECULE: BG505 SOSIP GP41; FRAGMENT: UNP RESIDUES 509 - 661; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH ElectronMicroscopy N/A N/A FAB 30-SEP-16 20160930 IMMUNE SYSTEM STRUCTURAL BASIS FOR INHIBITION OF ERYTHROCYTE INVASION BY ANTIBODIES TO PLASMODIUM FALCIPARUM PROTEIN CYRPA MOLECULE: CYSTEINE - RICH PROTECTIVE ANTIGEN; FRAGMENT: UNP RESIDUES 30 - 362; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQEISGYLS 7 TASTVDS 9 LQYDTYPWT 5 SFWMH 17 MIDPSENKIRLNQNFKD 5 VRRGY crystal 2.44A 19.00% FAB 03-OCT-16 20161003 IMMUNE SYSTEM COMPUTER - BASED RATIONAL DESIGN OF IMPROVED FUNCTIONALITY FOR ANTIBODY CATALYSTS TOWARD ORGANOPHOSPHORUS COMPOUNDS ? ? ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 10 GTWDSSLNPV 6 SGYYWG 16 SIYHSGSTYYNPSLKS 7 LTQNDAN crystal 2.10A 19.80% FAB 04-OCT-16 20161004 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA A VIRUS NUCLEOPROTEIN IN COMPLEX WITH INHIBITORY NANOBODY MOLECULE: NUCLEOPROTEIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 SYAQG 19 VASLRTHDGNTHYTDSVKG 14 SLGYSGAYASGYDY crystal 3.23A 21.00% HC-dimer 05-OCT-16 20161005 IMMUNE SYSTEM STRUCTURE OF VACCINE - ELICITED DIVERSE HIV - 1 NEUTRALIZING ANTIBODY VFP1.01 IN COMPLEX WITH HIV - 1 FUSION PEPTIDE RESIDUE 512 - 519 MOLECULE: HIV - 1 FUSION PEPTIDE RESIDUE 512 - 519; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVYSDGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 DYEIH 17 AIVPKTGYTAYNQKFRG 9 LRNYWYFDV crystal 2.12A 20.00% ? 06-OCT-16 20161006 IMMUNE SYSTEM STRUCTURE OF MOUSE VACCINATION - ELICITED HIV NEUTRALIZING ANTIBODY VFP5.01 IN COMPLEX WITH HIV - 1 FUSION PEPTIDE RESIDUE 512 - 519 MOLECULE: HIV - 1 FUSION PEPTIDE RESIDUE 512 - 519; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQNVGSDVA 7 SASNRYT 9 QQYSSYPLT 6 RAYYWN 16 YILYDGRSDYNPSLKN 7 EGNYRAY crystal 1.55A 21.10% ? 06-OCT-16 20161006 IMMUNE SYSTEM COMPLEX BETWEEN HUMAN CD27 AND ANTIBODY M2177 MOLECULE: CD27 ANTIGEN; FRAGMENT: EXTRACELLULAR DOMAIN RESIDUES 21 - 121; SYNONYM: CD27L RECEPTOR,T - CELL ACTIVATION ANTIGEN CD27,T14,TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 7; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 15 KASQSVDYAGDSYMN 7 AASNLES 9 QQSNEDPYT 5 SSWMN 17 RIYPGDGDTNYNGKFKG 11 SDYYGDYGFAY crystal 1.80A 19.70% ? 10-OCT-16 20161010 IMMUNE SYSTEM COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191 MOLECULE: CD27 ANTIGEN; FRAGMENT: EXTRACELLULAR DOMAIN RESIDUES 21 - 121; SYNONYM: CD27L RECEPTOR,T - CELL ACTIVATION ANTIGEN CD27,T14,TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 7; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 15 RASKSVSTSGYSFMH 7 LASNLES 9 QHSRELPWT 5 SSWMN 17 RIYPGDGDTNYNGKFKG 11 SDYYGDYGFAY crystal 3.50A 28.70% FAB 11-OCT-16 20161011 IMMUNE SYSTEM COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191 MOLECULE: CD27 ANTIGEN; FRAGMENT: EXTRACELLULAR DOMAIN RESIDUES 21 - 121; SYNONYM: CD27L RECEPTOR,T - CELL ACTIVATION ANTIGEN CD27,T14,TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 7; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 15 RASKSVSEGRWSFMH 7 VASRLES 9 QHSRELPWT 5 SSWMN 17 RIYPGDGDTNYNGKFKG 11 SDYYGDYGFAY crystal 2.70A 21.40% FAB 11-OCT-16 20161011 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RSV F GLYCOPROTEIN IN COMPLEX WITH THE NEUTRALIZING SINGLE - DOMAIN ANTIBODY F - VHH - 4 MOLECULE: FUSION GLYCOPROTEIN F0, FIBRITIN CHIMERA; SYNONYM: PROTEIN F; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YYYIG 17 CISGSSGSTYYPDSVKG 16 IRSSSWGGCVHYGMDY crystal 3.30A 18.70% HC-dimer 17-OCT-16 20161017 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RSV F GLYCOPROTEIN IN COMPLEX WITH THE NEUTRALIZING SINGLE - DOMAIN ANTIBODY F - VHH - L66 MOLECULE: FUSION GLYCOPROTEIN F0, FIBRITIN CHIMERA; SYNONYM: PROTEIN F; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YYYIG 17 CISSSHGSTYYADSVKG 16 VAVAHFRGCGVDGMDY crystal 3.80A 24.90% HC-dimer 17-OCT-16 20161017 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE RSV - NEUTRALIZING SINGLE - DOMAIN ANTIBODY F - VHH - 4 MOLECULE: F - VHH - 4; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 YYYIG 17 CISGSSGSTYYPDSVKG 16 IRSSSWGGCVHYGMDY crystal 1.87A 17.50% HC-dimer 19-OCT-16 20161019 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH270.3 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332 - GLYCAN DEPENDENT LINEAGE ? ? ? HOMO SAPIENS 14 TGSSSDVGSYNLVS 7 EVNKWAS 10 SSSTNSATVI 5 DYYVH 17 WINPTSGRTISPRKFQG 18 GGWISLYVDYSYYPNFDS crystal 2.50A 21.70% FAB 20-OCT-16 20161020 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RSV F IN COMPLEX WITH HUMAN ANTIBODY HRSV90 MOLECULE: FUSION GLYCOPROTEIN F0,FIBRITIN; SYNONYM: PROTEIN F; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQSVISNLA 7 GASTRAT 9 QQYNNWPLT 5 DYTIH 17 GITWNSGYIGYADSVKG 16 DAYVSGSDYYYYGLDV crystal 3.14A 22.60% ? 20-OCT-16 20161020 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH270.5 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332 - GLYCAN DEPENDENT LINEAGE ? ? ? HOMO SAPIENS 14 TGTIYDVGKFDLVS 7 EVKKWPS 11 CSFGGSAAVVC 5 DFYIH 17 WMNPKTGRTNQGQNFQG 18 GAWISDYYDSSYYPNFDH crystal 1.85A 18.10% FAB 20-OCT-16 20161020 IMMUNE SYSTEM STRUCTURE OF A FC HETERODIMER ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 20.60% FC 21-OCT-16 20161021 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2A IN COMPLEX WITH ZINC AT THE GLUN2A MOLECULE: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A; FRAGMENT: RESIDUES 34 - 393; SYNONYM: GLUN2A,GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON - 1,N - METHYL D - ASPARTATE RECEPTOR SUBTYPE 2A,NR2A; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIADYLY 2 KY 9 QNGHSFPRT 5 NYGMN 17 WINIYTGEPTYADDFKG 10 GYDYEGYFDY crystal 2.91A 20.40% FAB 21-OCT-16 20161021 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2A IN THE PRESENCE OF EDTA MOLECULE: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A; FRAGMENT: RESIDUES 34 - 393; SYNONYM: GLUN2A,GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON - 1,N - METHYL D - ASPARTATE RECEPTOR SUBTYPE 2A,NR2A; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIADYLY 0 N/A 9 QNGHSFPRT 5 NYGMN 17 WINIYTGEPTYADDFKG 10 GYDYEGYFDY crystal 2.70A 21.20% FAB 21-OCT-16 20161021 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2A IN COMPLEX WITH ZINC AT GLUN1 AND GLUN2A MOLECULE: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A; FRAGMENT: RESIDUES 34 - 393; SYNONYM: GLUN2A,GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON - 1,N - METHYL D - ASPARTATE RECEPTOR SUBTYPE 2A,NR2A; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSIADYLY 0 N/A 9 QNGHSFPRT 5 NYGMN 17 WINIYTGEPTYADDFKG 10 GYDYEGYFDY crystal 3.29A 22.80% FAB 21-OCT-16 20161021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH270.6 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332 - GLYCAN DEPENDENT LINEAGE ? ? ? HOMO SAPIENS 14 TGTKYDVGSHDLVS 7 EVNKRPS 11 CSFGGSATVVC 5 DFYIH 17 WMNPQTGRTNTARNFQG 18 GGWISLYYDSSYYPNFDH crystal 2.72A 18.80% FAB 23-OCT-16 20161023 TRANSPORT PROTEIN CRYO - ELECTRON MICROSCOPY STRUCTURE OF A BOVINE CLC - K CHLORIDE CHANNEL, MAIN (CLASS 1) CONFORMATION MOLECULE: CHLORIDE CHANNEL PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 WASYRYS 9 QQYNSYPLT 6 SDYAWS 16 YITYSGNTIYNPSLKS 4 GVDY ElectronMicroscopy N/A N/A FAB 24-OCT-16 20161024 TRANSPORT PROTEIN CRYO - ELECTRON MICROSCOPY STRUCTURE OF A BOVINE CLC - K CHLORIDE CHANNEL, ALTERNATE (CLASS 2) CONFORMATION MOLECULE: CHLORIDE CHANNEL PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 WASYRYS 9 QQYNSYPLT 6 SDYAWS 16 YITYSGNTIYNPSLKS 4 GVDY ElectronMicroscopy N/A N/A FAB 25-OCT-16 20161025 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VACCINE - ELICITED PAN - INFLUENZA H1N1 NEUTRALIZING MURINE ANTIBODY 441D6. ? ? ? MUS, MUS MUSCULUS 11 KASQDIYSSFS 7 RANRLVD 9 LQHEEFPPT 5 RFDMS 17 YIRNGADDTYYADTEKG 10 HSGYSYVIDY crystal 2.01A 17.60% FAB 25-OCT-16 20161025 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE UNLIGANDED DH270 COOPERATING LINEAGE MEMBER DH272 ? ? ? HOMO SAPIENS 16 RSSQSLVHNYGNTYLN 7 KVSGRDS 9 MQGTHWPRT 5 DHYIN 15 WINPGNSVTHYAQKF 15 EPYDFHSGLEGSLDY crystal 2.69A 21.40% FAB 27-OCT-16 20161027 IMMUNE SYSTEM STRUCTURE OF THE FIRST - IN - CLASS CHECKPOINT INHIBITOR IPILIMUMAB BOUND TO HUMAN CTLA - 4 MOLECULE: CYTOTOXIC T - LYMPHOCYTE PROTEIN 4; FRAGMENT: UNP RESIDUES 37 - 154; SYNONYM: CYTOTOXIC T - LYMPHOCYTE - ASSOCIATED ANTIGEN 4,CTLA - 4; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGSSYLA 7 GAFSRAT 9 QQYGSSPWT 5 SYTMH 17 FISYDGNNKYYADSVKG 9 TGWLGPFDY crystal 3.00A 20.70% FAB 27-OCT-16 20161027 MEMBRANE PROTEIN, HYDROLASE THERMUS THERMOPHILUS V / A - ATPASE BOUND TO VH DABS MOLECULE: V - TYPE ATP SYNTHASE ALPHA CHAIN; SYNONYM: V - ATPASE SUBUNIT A; EC: 3.6.3.14; ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 TYMMS 17 SIEGSGSKTYYADSVKG 9 RDSSFGFDY ElectronMicroscopy N/A N/A HC-dimer 29-OCT-16 20161029 SIGNALING PROTEIN STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR RECOGNITION OF THE HUMAN SEROTONIN 2B RECEPTOR BY AN ANTIBODY MOLECULE: 5 - HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA; FRAGMENT: UNP P41595 RESIDUES 36 - 248 AND 314 - 405 LINKED BY UNP P0ABE7 RESIDUES 23 - 128; SYNONYM: 5 - HT2B,SEROTONIN RECEPTOR 2B,CYTOCHROME B - 562; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 STSNLAS 9 QQRSSYPLT 5 SSWMH 17 NIYPSNGGTNYNERFKS 18 FGSFITTILTTYYNPVDY crystal 3.00A 22.80% FAB 05-NOV-16 20161105 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING INFLUENZA A ANTIBODY VRC 315 13 - 1B02 FAB. ? ? ? HOMO SAPIENS 11 RASQTISRYLN 7 DASRLQS 10 QQSDSIPALT 5 NYGMN 17 YITGASATVYYAASVRG 21 DRGCNSPTCFVIGYYYYGMDV crystal 1.36A 16.00% FAB 18-NOV-16 20161118 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN CD47 ECD BOUND TO FAB OF C47B222 MOLECULE: LEUKOCYTE SURFACE ANTIGEN CD47; FRAGMENT: EXTRACELLULAR DOMAIN, UNP RESIDUES 19 - 141; SYNONYM: ANTIGENIC SURFACE DETERMINANT PROTEIN OA3,INTEGRIN - ASSOCIATED PROTEIN,IAP,PROTEIN MER6; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSVNNRLA 7 WASTRAI 9 QQGASWPFT 5 DYWIG 17 IIYPGDSDTRYSPSFQG 11 VGRFASHQLDY crystal 2.30A 20.40% FAB 21-NOV-16 20161121 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN CD47 ECD BOUND TO FAB OF C47B161 MOLECULE: LEUKOCYTE SURFACE ANTIGEN CD47; FRAGMENT: EXTRACELLULAR DOMAIN, UNP RESIDUES 19 - 141; SYNONYM: ANTIGENIC SURFACE DETERMINANT PROTEIN OA3,INTEGRIN - ASSOCIATED PROTEIN,IAP,PROTEIN MER6; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: RESIDUE 1 IS A GLN THAT CYCLIZES AS PYROGLUTAMATE (PCA) ? ? HOMO SAPIENS 16 RSRQSIVHTNRYTYLA 7 KVSNRFS 9 FQGSHVPYT 5 DYNMH 17 DIYPYNGGTGYNQKFKG 8 GGWHAMDS crystal 2.89A 26.10% FAB 22-NOV-16 20161122 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN CD47 ECD BOUND TO FAB OF B6H12.2 MOLECULE: LEUKOCYTE SURFACE ANTIGEN CD47; FRAGMENT: EXTRACELLULAR DOMAIN, UNP RESIDUES 19 - 141; SYNONYM: ANTIGENIC SURFACE DETERMINANT PROTEIN OA3,INTEGRIN - ASSOCIATED PROTEIN,IAP,PROTEIN MER6; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQTISDYLH 7 FASQSIS 9 QNGHGFPRT 5 GYGMS 17 TITSGGTYTYYPDSVKG 9 SLAGNAMDY crystal 2.10A 17.90% FAB 22-NOV-16 20161122 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH270.UCA1 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332 - GLYCAN DEPENDENT LINEAGE MOLECULE: DH270.UCA1 LIGHT CHAIN; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGTSSDVGSYNLVS 7 EVSKRPS 10 CSYAGSSIIL 5 GYYMH 17 WINPNSGGTNYAQKFQG 18 GGWIGLYYDSSGYPNFDY crystal 3.30A 24.70% FAB 26-NOV-16 20161126 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH270.1 (UNLIGANDED, SINGLE - CHAIN FV) FROM THE DH270 BROADLY NEUTRALIZING N332 - GLYCAN DEPENDENT LINEAGE ? ? ? HOMO SAPIENS 13 KASGYTFTDYYIH 7 INPSTGR 15 DTAMYYCTTGGWIGL 5 DYYIH 17 WINPSTGRTNSPQKFQG 26 GGWIGLYSDTSGYPNFDYWGQGTLVT crystal 3.43A 25.50% scFv 27-NOV-16 20161127 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH270.UCA3 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332 - GLYCAN DEPENDENT LINEAGE MOLECULE: DH270.UCA3 LIGHT CHAIN; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGTSSDVGSYNLVS 7 EVSKRPS 10 CSYAGSSTVI 5 GYYMH 17 WINPNSGGTNYAQKFQG 18 GGWISLYYDSSGYPNFDY crystal 2.26A 21.80% FAB 27-NOV-16 20161127 IMMUNE SYSTEM STRUCTURE OF MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; FRAGMENT: UNP RESIDUES 101 - 151; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.77A 15.80% FAB 01-DEC-16 20161201 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DH511.1 FAB IN COMPLEX WITH HIV - 1 GP41 MPER PEPTIDE MOLECULE: GP41 MPER PEPTIDE; FRAGMENT: GP41 656 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQKISDYLN 7 AASKLGS 11 QEAYSSTPTLT 5 NTWMS 19 RISRNKDGAKTEYAAPVRG 22 DLGEPVVSRFFEWGSYYYYMDL crystal 2.74A 23.10% FAB 02-DEC-16 20161202 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DH511.2 FAB IN COMPLEX WITH HIV - 1 GP41 MPER 662 - 683 PEPTIDE MOLECULE: GP41 MPER PEPTIDE; FRAGMENT: GP41 656 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQNIRDYLN 7 AASTLQT 11 QENYNTIPSLS 5 NSWMG 19 RIRRLKDGATGEYGAAVKD 21 DEGTPVTRFLEWGYFYYYMAV crystal 2.64A 23.40% FAB 02-DEC-16 20161202 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DH511.2 FAB IN COMPLEX WITH HIV - 1 GP41 MPER 670 - 683 PEPTIDE MOLECULE: GP41 MPER PEPTIDE; FRAGMENT: GP41 656 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQNIRDYLN 7 AASTLQT 11 QENYNTIPSLS 5 NSWMG 19 RIRRLKDGATGEYGAAVKD 21 DEGTPVTRFLEWGYFYYYMAV crystal 2.17A 20.60% FAB 02-DEC-16 20161202 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DH511.11P FAB IN COMPLEX WITH HIV - 1 GP41 MPER PEPTIDE MOLECULE: GP41 MPER PEPTIDE; FRAGMENT: GP41 656 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSIKDYLN 7 SASKLRS 11 QESYSSVPMYI 5 NTWMS 19 RISRVGDGPIIDYAAPVKG 21 DEGAPILRFFEWGYYNYYMDV crystal 2.42A 23.10% FAB 02-DEC-16 20161202 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DH511.12P FAB IN COMPLEX WITH HIV - 1 GP41 MPER PEPTIDE MOLECULE: GP41 MPER PEPTIDE; FRAGMENT: GP41 656 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSIKDYLN 7 SASKLRS 11 QESYSSVPMYI 5 NTWMS 19 RISRVGDGPIIDYAAPVKG 21 DEGAPILRFFEWGYYNYYMDV crystal 2.00A 18.40% FAB 02-DEC-16 20161202 IMMUNE SYSTEM / VIRAL PROTEIN CRYSTAL STRUCTURE OF DH511.2_K3 FAB IN COMPLEX WITH HIV - 1 GP41 MPER PEPTIDE MOLECULE: GP41 MPER PEPTIDE; FRAGMENT: GP41 656 - 683; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQNIKDYLN 7 AASNLQS 11 QESYSSTPTHI 5 NSWMG 19 RIRRLKDGATGEYGAAVKD 21 DEGTPVTRFLEWGYFYYYMAV crystal 1.76A 16.20% FAB 02-DEC-16 20161202 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH511.4 FAB ? ? ? HOMO SAPIENS 11 RASQSIKDYIN 7 AASTLQS 11 QEAYNTNPTLS 7 FANDWMG 19 RIRRLKDGAKAEYGSSVKG 21 DEGAPVTRFLEWGSYYYYMAV crystal 1.50A 18.90% FAB 02-DEC-16 20161202 HYDROLASE / IMMUNE SYSTEM RTA - V1C7_G29R - HIGH - SALT MOLECULE: RICIN; FRAGMENT: RESIDUES 36 - 302; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 7 SRFTLDY 18 EGLSSISSSSDGFTSYSD 19 YCAARLGGWASFSPQEYDY crystal 2.50A 21.20% HC-dimer 05-DEC-16 20161205 HYDROLASE / IMMUNE SYSTEM RTA - V1C7 - G29R - NO_SALT MOLECULE: RICIN; FRAGMENT: RESIDUES 40 - 294; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 7 RFTLDYY 18 GLSSISSSSDGFTSYSDS 18 CAARLGGWASFSPQEYDY crystal 2.50A 20.50% HC-dimer 05-DEC-16 20161205 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING INFLUENZA A ANTIBODY VRC 315 53 - 1A09 FAB. ? ? ? HOMO SAPIENS 11 RASQRIRNYLN 7 TASKLQG 9 QQSHETPLT 5 DYHAT 17 YISGSGSTTYYADAVKG 21 TRLGDIVQAPGVIGYYYGMDV crystal 1.76A 17.90% FAB 05-DEC-16 20161205 TRANSCRIPTION IGG FC BOUND TO 3 HELIX OF THE B - DOMAIN FROM PROTEIN A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686C11235; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280; GENE: SPA; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 19.50% FC 06-DEC-16 20161206 IMMUNE SYSTEM 2 HELIX MINIMIZED VERSION OF THE B - DOMAIN FROM PROTEIN A (Z34C0 BOUND TO IGG1 FC (MONOCLINIC FORM) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686C11235; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280; EXPRESSION_SYSTEM: SYNTHETIC CONSTRUCT; EXPRESSION_SYSTEM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.94A 19.20% FC 06-DEC-16 20161206 IMMUNE SYSTEM MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT IN COMPLEX WITH (AC) CQFDA (PH) 2STRRLRCGGSK MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; FRAGMENT: UNP RESIDUES 101 - 151; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.81A 16.40% FAB 06-DEC-16 20161206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF I83E MEDITOPE - ENABLED TRASTUZUMAB WITH AZIDO - MEDITOPE MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; FRAGMENT: RESIDUES 101 - 151; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.88A 16.30% ? 06-DEC-16 20161206 IMMUNE SYSTEM CAMEL NANOBODY VHH - 28 ? ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 RPCIG 14 VNFRGDSTYITDSV 17 DVNRGGFCYIEDWYFSY crystal 1.15A 14.70% HC-dimer 07-DEC-16 20161207 IMMUNE SYSTEM CAMEL NANOBODY VHH - 5 MOLECULE: VHH - 5; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 NYCMR 16 SINSAGTTYYADSVKG 19 STRVWGGYCGGLDDATNND crystal 2.30A 20.40% HC-dimer 07-DEC-16 20161207 IMMUNE SYSTEM / INHIBITOR MODIFIED SINGLE HELIX FROM THE B - DOMAIN OF PROTEIN A BOUND TO IGG1 FC ? ? IGG1 MOL_ID: 1; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686C11235; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.70A 16.40% FC 07-DEC-16 20161207 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURAL BASIS FOR ANTIBODY CROSS - NEUTRALIZATION OF RESPIRATORY SYNCYTIAL VIRUS AND HUMAN METAPNEUMOVIRUS MOLECULE: CHIMERA PROTEIN OF FUSION GLYCOPROTEIN F0 AND ENVELOPE GLYCOPROTEIN; FRAGMENT: UNP P03420 RESIDUES 1 - 513,UNP M1E1E4 RESIDUES 1 - 28; SYNONYM: PROTEIN F; ENGINEERED: YES; ? ? MYZUS PERSICAE Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 3.08A 18.70% scFv 07-DEC-16 20161207 IMMUNE SYSTEM CRYSTAL STRUCTURE OF I83E MEDITOPE - ENABLED TRASTUZUMAB WITH AZIDO - PEG3 - MEDITOPE MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; FRAGMENT: UNP RESIDUES 101 - 151; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.74A 16.10% ? 07-DEC-16 20161207 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR BMS - 378806 IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 3.8 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 509 - 661; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.03A 24.80% FAB 12-DEC-16 20161212 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR BMS - 626529 IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 3.8 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 509 - 661; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.03A 27.50% FAB 12-DEC-16 20161212 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MUTANT MIGG2B FC HETERODIMER IN COMPLEX WITH PROTEIN A PEPTIDE ANALOG Z34C ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGH-3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: EXPI293F; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGH-3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: EXPI293F; MOL_ID: 3; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 21.20% FC 21-DEC-16 20161221 IMMUNE SYSTEM FAB STRUCTURE OF ANTI - HIV - 1 GP120 MAB 1A8 ? ? ? HOMO SAPIENS 11 GGNNIGSKNVH 7 DYTDRPS 11 QVWDSSGDHVV 7 SSDYYWG 16 SMSYSGRTYYNPSLKS 11 HWRYSGGLFDY crystal 2.60A 19.10% FAB 21-DEC-16 20161221 IMMUNE SYSTEM FAB STRUCTURE OF HIV GP120 SPECIFIC MAB 1E12 ? ? ? HOMO SAPIENS 13 SGSSSNIGSNTVN 7 SSNQRPS 11 ATWDDSLNGVI 7 SDSHYWG 19 STSDSGSTYHNRPIYYNPS 14 CVRQWRYSSGSLDC crystal 2.75A 19.30% FAB 21-DEC-16 20161221 IMMUNE SYSTEM STRUCTURE OF ANTIGEN - FAB COMPLEX WITH ENGINEERED SWITCH RESIDUE REGION. MOLECULE: HISTONE CHAPERONE ASF1; SYNONYM: ANTI - SILENCING FUNCTION PROTEIN 1,YASF1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQDGWSLIT 5 YYSIH 17 SIYPYYGSTSYADSVKG 8 GYGWALDY crystal 1.52A 14.00% FAB 22-DEC-16 20161222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 354BG18 FAB MOLECULE: LIGHT CHAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGAPLTSRFTY 2 SR 11 QSSDTSDSYKM 6 SDHSWT 16 DIHYNGATTYNPSLRS 21 NAIRIYGVVALGEWFHYGMDV crystal 1.30A 18.00% FAB 23-DEC-16 20161223 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF RSV F A2 BOUND TO MEDI8897 MOLECULE: FUSION GLYCOPROTEIN F0; SYNONYM: PROTEIN F; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 QASQDIVNYLN 7 VASNLET 9 QQYDNLPLT 5 DYIIN 17 GIIPVLGTVHYGPKFQG 17 ETALVVSETYLPHYFDN crystal 3.45A 17.80% FAB 26-DEC-16 20161226 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF RSV F B9320 BOUND TO MEDI8897 MOLECULE: FUSION GLYCOPROTEIN F0; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 QASQDIVNYLN 7 VASNLET 9 QQYDNLPLT 5 DYIIN 17 GIIPVLGTVHYGPKFQG 17 ETALVVSETYLPHYFDN crystal 4.30A 23.90% FAB 26-DEC-16 20161226 IMMUNE SYSTEM STRUCTURE OF ANTIGEN - FAB COMPLEX WITH HISTONE CHAPERONE ASF1 MOLECULE: HISTONE CHAPERONE ASF1; SYNONYM: ANTI - SILENCING FUNCTION PROTEIN 1,YASF1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSQWYPIT 5 YSSIH 17 YIYPSSGYTSYADSVKG 10 SYSTKLAMDY crystal 1.70A 15.70% FAB 29-DEC-16 20161229 IMMUNE SYSTEM STRUCTURE OF ANTIGEN - FAB 12E COMPLEX WITH HISTONE CHAPERONE ASF1 MOLECULE: HISTONE CHAPERONE ASF1; SYNONYM: ANTI - SILENCING FUNCTION PROTEIN 1,YASF1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQDGWSLIT 5 YYSIH 17 SIYPYSGSTSYADSVKG 8 GYGWALDY crystal 1.70A 17.80% FAB 02-JAN-17 20170102 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 354NC102 FAB ? ? ? HOMO SAPIENS 12 RASHGLDTSHLA 7 GTSSRPP 10 QNSGGGTPLI 5 DYYIH 18 LIKVGHGGAAIYAPNLRG 19 DNFGTRPVPGRGYYYGMDV crystal 1.60A 17.70% FAB 02-JAN-17 20170102 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 354NC37 FAB IN COMPLEX WITH HIV - 1 CLADE AE STRAIN 93TH057 GP120 MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASYGLDTSHLA 7 GTSSRPP 10 QNSGGGTPLI 5 DYYIH 18 LIKVGHGGGAMYAPSLQG 19 DNFGTRPVPGRGYYYGMDV crystal 2.70A 22.20% FAB 02-JAN-17 20170102 VIRAL PROTEIN / IMMUNE SYSTEM HUMAN ANTIBODY H2897 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ H1 SOLOMON ISLANDS / 03 / 2006 MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 344 - 519; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSYYLG 7 ETSRRAT 10 QHYGVSPVIT 5 IYDMH 16 SITTAGDTYYPGSVKG 19 GVREVGATGDDPFYYGMYV crystal 3.40A 24.20% ? 06-JAN-17 20170106 VIRAL PROTEIN / IMMUNE SYSTEM INFLUENZA HEMAGGLUTININ IN COMPLEX WITH A NEUTRALIZING ANTIBODY MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 344 - 516; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNDIGRKSVH 7 YDSDRPS 11 QVWDSSSDHVI 5 DYHIN 17 WIHPNSGDTNYAQKFQG 17 GGLEPRSVDYYYYGMDV crystal 2.80A 26.00% FAB 10-JAN-17 20170110 VIRUS / IMMUNE SYSTEM A HUMAN ANTIBODY AGAINST ZIKA VIRUS CROSSLINKS THE E PROTEIN TO PREVENT INFECTION MOLECULE: ENVELOPE PROTEIN; FRAGMENT: ECTODOMAIN (UNP RESIDUES 1 - 396); SYNONYM: E; ENGINEERED: YES ? ? HOMO SAPIENS 11 KASQNVGTAVA 7 SASNRYT 9 QQFSSYPYT 5 SYGIS 17 VIYPRSGNTYYNEKFRG 7 ENYGSVY ElectronMicroscopy N/A N/A FAB 12-JAN-17 20170112 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE DH576 CD4BS FAB (UNLIGANDED) FROM THE RV305 HIV VACCINE TRIAL ? ? ? HOMO SAPIENS 11 QASQDIDNYLN 7 DASNLET 9 QKYGSVPFP 5 NYAIH 17 LISYDGKKQYYLDSVKG 21 DRARSTGYFGGIYYYYYGMDV crystal 2.50A 21.30% FAB 15-JAN-17 20170115 VIRAL PROTEIN / IMMUNE SYSTEM CRYOEM STRUCTURE OF AN INFLUENZA VIRUS RECEPTOR - BINDING SITE ANTIBODY - ANTIGEN INTERFACE - CLASS 1 MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 344 - 516; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 19-JAN-17 20170119 VIRAL PROTEIN / IMMUNE SYSTEM CRYOEM STRUCTURE OF AN INFLUENZA VIRUS RECEPTOR - BINDING SITE ANTIBODY - ANTIGEN INTERFACE - CLASS 2 MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 344 - 516; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 19-JAN-17 20170119 VIRAL PROTEIN / IMMUNE SYSTEM CRYOEM STRUCTURE OF AN INFLUENZA VIRUS RECEPTOR - BINDING SITE ANTIBODY - ANTIGEN INTERFACE - CLASS 3 MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 344 - 516; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 19-JAN-17 20170119 VIRAL PROTEIN / IMMUNE SYSTEM CRYOEM STRUCTURE OF AN INFLUENZA VIRUS RECEPTOR - BINDING SITE ANTIBODY - ANTIGEN INTERFACE - CLASS 4 MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 344 - 516; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 19-JAN-17 20170119 VIRAL PROTEIN / RNA / IMMUNE SYSTEM VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 MOLECULE: NUCLEOPROTEIN; SYNONYM: NP,NUCLEOCAPSID PROTEIN,PROTEIN N; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 NSIMG 19 VAKISWRNDYTTYADSVKG 16 TKAYNGGETSGRGFYY crystal 3.20A 23.70% HC-dimer 19-JAN-17 20170119 VIRAL PROTEIN / RNA / IMMUNE SYSTEM VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 MOLECULE: NUCLEOCAPSID; SYNONYM: NUCLEOCAPSID PROTEIN; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 NYRLG 17 AINWGGVITNYADSVKG 15 FDSTGSPIVRDNYEY crystal 5.47A 33.70% HC-dimer 20-JAN-17 20170120 IMMUNE SYSTEM STRUCTURE OF UNLIGANDED ANTI - GP120 CD4BS ANTIBODY DH522UCA FAB ? ? ? MACACA MULATTA 14 TGTSSDIGGYNGVS 7 EVSKRPS 10 GSYRSGSTWV 6 DDYYWS 17 YIYGSGGGTNYNPSLKN 15 GSYNIVVLFGYYFDY crystal 1.75A 16.80% FAB 23-JAN-17 20170123 IMMUNE SYSTEM STRUCTURE OF UNLIGANDED ANTI - GP120 CD4BS ANTIBODY DH522IA FAB ? ? ? MACACA MULATTA 14 SGTSSDIGAYNGVS 7 EVSKRPS 10 GSYRSGSTWV 6 DDYYWN 17 SIYGSFGGTNYNPSLKN 15 GSYNIVVLFGYYFDY crystal 2.30A 18.90% FAB 23-JAN-17 20170123 IMMUNE SYSTEM STRUCTURE OF UNLIGANDED ANTI - GP120 CD4BS ANTIBODY DH522.1 FAB ? ? ? MACACA MULATTA 14 SGTSSDIGAYNGVS 7 EVSKRPS 10 GSYRSGSTWV 6 DDYYWN 17 SIYGSFGGTNYNPSLKS 15 GSYNIVVLFGYYFDY crystal 2.00A 19.40% FAB 23-JAN-17 20170123 IMMUNE SYSTEM STRUCTURE OF UNLIGANDED ANTI - GP120 CD4BS ANTIBODY DH522.2 FAB ? ? ? MACACA MULATTA 14 SGTTNDIGAYNGVS 7 EVNKRPS 10 GSYRSGSTWV 6 DDYYWN 17 SIYGSFGGTNFNPSLKN 15 GSHSIVVLFGYYFDY crystal 2.10A 17.70% FAB 23-JAN-17 20170123 IMMUNE SYSTEM STRUCTURE OF UNLIGANDED ANTI - GP120 CD4BS ANTIBODY DH522.2 FAB IN COMPLEX WITH A GP120 CORE MOLECULE: CHIMERIC B.YU2 GP120 CORE DERIVED FROM HIV - 1 ENV; ENGINEERED: YES ? ? MACACA MULATTA 14 SGTTNDIGAYNGVS 7 EVNKRPS 10 GSYRSGSTWV 6 DDYYWN 17 SIYGSFGGTNFNPSLKN 15 GSHSIVVLFGYYFDY crystal 2.71A 20.60% FAB 23-JAN-17 20170123 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 ENVELOPE TRIMER 16055 NFL TD CC (T569G) IN COMPLEX WITH FABS 35022 AND PGT124 MOLECULE: GLYCOPROTEIN GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.94A 26.30% FAB 26-JAN-17 20170126 TOXIN / IMMUNE SYSTEM CLOSTRIDIUM DIFFICILE TCDA - CROPS BOUND TO PA50 FAB MOLECULE: TOXIN A; FRAGMENT: UNP RESIDUES 2461 - 2710; EC: 3.4.22. -; ENGINEERED: YES; ? ? HOMO SAPIENS 10 RASSSVNYMN 7 ATSNLAS 7 QQWSSRT 5 DYNMD 17 DINPKYDIIGHNPKFMG 9 SDRGWYFDV crystal 3.23A 27.10% FAB 27-JAN-17 20170127 IMMUNE SYSTEM CRYSTAL STRUCTURE OF C05 VPGSGW MUTANT BOUND TO H3 INFLUENZA HEMAGGLUTININ, HA1 SUBUNIT MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIRKFLN 7 DASNLQR 9 QQYDGLPFT 7 ESTLSYY 17 WLSIINAGGGDIDYADS 26 CAKHMSMQQVPGSGWERADLVGDAFD crystal 1.97A 18.30% FAB 27-JAN-17 20170127 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF ELBOW - ENGINEERED - FAB - BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) MOLECULE: INSULIN - DEGRADING ENZYME; SYNONYM: ABETA - DEGRADING PROTEASE,INSULIN PROTEASE,INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSYFNPIT 5 SSSIH 17 SIYSYSGSTYYADSVKG 10 HYSAVAGLDY crystal 3.80A 22.10% FAB 31-JAN-17 20170131 MEMBRANE PROTEIN TRIHETEROMERIC NMDA RECEPTOR GLUN1 / GLUN2A / GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, MK - 801 AND A GLUN2B - SPECIFIC FAB, AT PH 6.5 MOLECULE: N - METHYL - D - ASPARTATE RECEPTOR SUBUNIT NR2A; ENGINEERED: YES; ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 01-FEB-17 20170201 MEMBRANE PROTEIN TRIHETEROMERIC NMDA RECEPTOR GLUN1 / GLUN2A / GLUN2B IN COMPLEX WITH GLYCINE, GLUTAMATE, RO 25 - 6981, MK - 801 AND A GLUN2B - SPECIFIC FAB, AT PH 6.5 MOLECULE: N - METHYL - D - ASPARTATE RECEPTOR SUBUNIT NR2A; ENGINEERED: YES; ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 01-FEB-17 20170201 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF MARBURG VIRUS GP IN COMPLEX WITH THE HUMAN SURVIVOR ANTIBODY MR78 MOLECULE: ENVELOPE GLYCOPROTEIN GP2; FRAGMENT: UNP RESIDUES 436 - 637; SYNONYM: GP1,2,GP,VIRION SPIKE GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQVISNYLN 7 DTSNLKT 9 QQYENLQFT 7 SSSYYWG 16 SVYYSGGASYNPSLKS 15 IYGSGTFYYYFYMDV crystal 3.60A 22.30% FAB 08-FEB-17 20170208 IMMUNE SYSTEM HUMAN ANTIBODY FRAGMENT (FAB) TO MENINGOCOCCAL FACTOR H BINDING PROTEIN ? KAPPA ? HOMO SAPIENS 11 RASQSISVSLN 7 AASRLQS 10 QETYSDLMYT 5 NYWVV 17 SIHPRDSDARYSLSFEG 13 LSQVSGWSPWVGP crystal 1.76A 19.90% FAB 09-FEB-17 20170209 LIGASE / LIGASE INHIBITOR LEISHMANIA DONOVANI TYROSYL - TRNA SYNTHETASE IN COMPLEX WITH NANOBODY AND INHIBITOR MOLECULE: TYROSYL - TRNA SYNTHETASE, PUTATIVE; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NSWMY 17 RINAGGNTVDYKDSVKG 9 GLNRYAYDS crystal 2.75A 19.10% HC-dimer 13-FEB-17 20170213 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV66 MOLECULE: IMV MEMBRANE PROTEIN; FRAGMENT: UNP RESIDUES 1 - 235; ENGINEERED: YES; OTHER_DETAILS: CAH DOMAIN; ? ? HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GNINRPS 11 QSYDSSLSGAL 7 SNNYYWG 16 SIYYSGSTYYNPSLKS 13 HRRVLLWFGEFQL crystal 2.30A 22.00% FAB 13-FEB-17 20170213 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV304 MOLECULE: IMV MEMBRANE PROTEIN; FRAGMENT: UNP RESIDUES 1 - 235; ENGINEERED: YES; OTHER_DETAILS: CAH DOMAIN, RESIDUES 1 - 235; ? ? HOMO SAPIENS 11 SGDALPKQFAY 7 KDSERPS 11 QSVDNSGTYEV 5 NYWMS 16 NIKQDGSKKYYVDSVG 15 LNLELAVDAISEALK crystal 2.90A 24.90% FAB 13-FEB-17 20170213 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A STABILIZED DS - SOSIP.MUT4 BG505 GP140 HIV - 1 ENV TRIMER, CONTAINING MUTATIONS I201C - P433C (DS) , L154M, N300M, N302M, T320L IN COMPLEX WITH HUMAN ANTIBODIES PGT122 AND 35O22 AT 4.1 ANGSTROM MOLECULE: HIV - 1 BG505 STRAIN ENV GP41; FRAGMENT: UNP RESIDUES 509 - 661; SYNONYM: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.41A 24.40% FAB 15-FEB-17 20170215 CYTOKINE / IMMUNE SYSTEM HUMAN IL - 2 / FAB COMPLEX MOLECULE: INTERLEUKIN - 2; SYNONYM: IL - 2, T - CELL GROWTH FACTOR, TCGF; ENGINEERED: YES ? ? HOMO SAPIENS 13 TRSSGSIASNYVQ 7 EDNQRPS 11 YCQSYDSSNVV 7 SGGYYWS 16 YIYYSGSTYYNPSLKS 11 TPTVTGDWFDP crystal 2.75A 19.40% FAB 15-FEB-17 20170215 CRYSTAL STRUCTURE OF THE ADCC - POTENT, WEAKLY NEUTRALIZING HIV ENV CO - RECEPTOR BINDING SITE ANTIBODY N12 - I2 FAB IN COMPLEX WITH HIV - 1 CLADE A / E GP120 AND M48U1 MOLECULE: M48U1 CD4 MIMETIC PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPET 5 SYGIT 17 GIIPIFDVTNYAQNFQG 21 DSRDFSEPGTSYSHYYNIMDV crystal 3.19A 24.90% FAB 21-FEB-17 20170221 IMMUNE SYSTEM STRUCTURE OF ANTI - HIV TRIMER APEX ANTIBODY PGT143 ? ? ? HOMO SAPIENS 16 TSTQSLRHSNGANYLA 7 LGSQRAS 9 MQGLNRPWT 5 KYDVH 17 WMSHEGDKTESAQRFKG 26 GSKHRLRDYVLYDDYGLINYQEWNDY crystal 2.42A 23.10% FAB 23-FEB-17 20170223 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN FAB PGT144, A BROADLY REACTIVE AND POTENT HIV - 1 NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 16 TSTQSLRHSNGANYLA 7 LGSQRAS 9 MQGLNRPWT 5 KYDVH 17 WMSHEGDKTESAQRFKG 26 GSKHRLRDYVLDDYGLINQQEWNDYL crystal 2.90A 24.30% FAB 23-FEB-17 20170223 SIGNALING PROTEIN VOLTA PHASE PLATE CRYO - ELECTRON MICROSCOPY STRUCTURE OF A CALCITONIN RECEPTOR - HETEROTRIMERIC GS PROTEIN COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 24-FEB-17 20170224 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB H7.167 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A / SHANGHAI / 02 / 2013 (H7N9) MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; OTHER_DETAILS: HA2; KAPPA ? HOMO 17 KSSQSVLYSSNNKNYLA 7 WASTRES 10 QQYYSTPGLT 5 SYEMN 17 YISSSGSTIYYADSVKG 10 LWFGELFFDY crystal 4.66A 26.10% FAB 03-MAR-17 20170303 IMMUNE SYSTEM ENGINEERED HUMAN IGG FC DOMAIN AGLYCO801 ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: EXPI293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.32A 19.70% FC 08-MAR-17 20170308 IMMUNE SYSTEM ENGINEERED HUMAN IGG FC DOMAIN GLYCO801 (FC801) ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: EXPI293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.22A 23.80% FC 09-MAR-17 20170309 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF RABBIT ANTI - HIV - 1 GP120 V3 FAB 10A37 IN COMPLEX WITH V3 PEPTIDE JR - FL MOLECULE: ENVELOPE GLYCOPROTEIN, V3 REGION; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 11 QASEDIQRNLA 7 GVSNLES 13 QSALYTSATDICA 6 SGFFMC 18 CIYGGSNDNTYYANWAKG 12 DAGTSGYIAYNL crystal 2.55A 20.80% FAB 17-MAR-17 20170317 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF RABBIT ANTI - HIV - 1 GP120 V3 FAB 10A3 IN COMPLEX WITH V3 PEPTIDE CONB MOLECULE: ENVELOPE GLYCOPROTEIN GP120 V3 PEPTIDE OF CON B SEQUENCE; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 13 QSSQSVYPNNNLG 7 EASTLAS 13 LGAYDFTVAEGAA 5 AIAMC 17 CIATDTGSTYYANWAKG 4 NFYL crystal 1.90A 18.10% FAB 17-MAR-17 20170317 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE AT 3.7 A RESOLUTION OF GLYCOSYLATED HIV - 1 CLADE A BG505 SOSIP.664 PREFUSION ENV TRIMER WITH FOUR GLYCANS (N197, N276, N362, AND N462) REMOVED IN COMPLEX WITH NEUTRALIZING ANTIBODIES 3H+109L AND 35O22. MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 509 - 661; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 2.91A 33.00% FAB 20-MAR-17 20170320 IMMUNE SYSTEM CYRSTAL STRUCTURE OF ANTI - TAU ANTIBODY CBTAU - 7.1 FAB ? ? ? HOMO SAPIENS 12 RASQIISSNYLA 7 GASSRAT 9 QQYGTSPRT 5 SYWMH 17 RINSDGSDTNYADSVKG 9 GRSYGFFDY crystal 2.30A 17.40% FAB 20-MAR-17 20170320 IMMUNE SYSTEM CYRSTAL STRUCTURE OF ANTI - TAU ANTIBODY CBTAU - 22.1 FAB ? ? ? HOMO SAPIENS 16 RSSQSLLHRSGHKYLH 7 LGSNRAS 9 MQTLQTPWT 5 DYNVH 17 RISPNSGGTKYAQKFQG 12 GHCDGTTCSRAY crystal 1.64A 17.80% FAB 20-MAR-17 20170320 VIRAL PROTEIN / IMMUNE SYSTEM BG505 SOSIP.664 TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING HIV ANTIBODIES 3BNC117 AND PGT145 MOLECULE: GP41; FRAGMENT: UNP RESIDUES 509 - 661; SYNONYM: ENVELOPE GLYCOPROTEIN GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 7 QANGYLN 7 DGSKLER 8 QVYEFVVP 5 DYFIH 19 WINPKTGQPNNPRQFQGRV 12 ARQRSDYWDFDV ElectronMicroscopy N/A N/A ? 22-MAR-17 20170322 VIRAL PROTEIN / IMMUNE SYSTEM A BROADLY NEUTRALIZING ANTIBODY TARGETS THE DYNAMIC HIV ENVELOPE TRIMER APEX VIA A LONG, RIGIDIFIED, AND ANIONIC BETA - HAIRPIN STRUCTURE MOLECULE: GP41; FRAGMENT: UNP RESIDUES 509 - 661; SYNONYM: ENVELOPE GLYCOPROTEIN GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 7 QANGYLN 7 DGSKLER 8 QVYEFVVP 5 DYFIH 19 WINPKTGQPNNPRQFQGRV 12 ARQRSDYWDFDV ElectronMicroscopy N/A N/A FAB 22-MAR-17 20170322 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MOUSE IGG2A FC T370K MUTANT ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGHG; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL: HEK 293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.55A 17.00% FC 24-MAR-17 20170324 IMMUNE SYSTEM CRYSTAL STRUCTURE OF H7 - SPECIFIC ANTIBODY M826 IN COMPLEX WITH THE HA1 DOMAIN OF HEMAGGLUTININ FROM H7N9 INFLUENZA VIRUS MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 11 CRASQSISSYL 7 YAASSLQ 10 CQQSYSTPRT 5 SYAIS 17 GIIPIFGTANYAQKFQG 12 DPSFWAAEYFQH crystal 1.90A 19.20% ? 26-MAR-17 20170326 SIGNALING PROTEIN CRYSTAL STRUCTURE OF BETA - KLOTHO, DOMAIN 1 MOLECULE: BETA - KLOTHO; FRAGMENT: UNP RESIDIES 30 - 522; SYNONYM: BETAKLOTHO,KLOTHO BETA - LIKE PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 2 GG 17 AISWSGGTKLYADSVKG 15 RRINEVLTTAPDYDF crystal 1.70A 17.30% HC-dimer 27-MAR-17 20170327 SIGNALING PROTEIN CRYSTAL STRUCTURE OF BETA - KLOTHO MOLECULE: BETA - KLOTHO; FRAGMENT: UNP RESIDUES30 - 983; SYNONYM: BETAKLOTHO,KLOTHO BETA - LIKE PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 PYVGG 17 AISWSGGTKLYADSVKG 15 RRINEVLTTAPDYDF crystal 2.20A 18.70% HC-dimer 27-MAR-17 20170327 SIGNALING PROTEIN CRYSTAL STRUCTURE OF BETA - KLOTHO IN COMPLEX WITH FGF21CT MOLECULE: FIBROBLAST GROWTH FACTOR 21; FRAGMENT: UNP RESIDUES 186 - 209; SYNONYM: FGF - 21; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 2 GG 17 AISWSGGTKLYADSVKG 15 RRINEVLTTAPDYDF crystal 2.61A 19.30% HC-dimer 27-MAR-17 20170327 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 5H8 MOLECULE: PEPTIDASE 1; SYNONYM: ALLERGEN DER P I, MAJOR MITE FECAL ALLERGEN DER P 1; ? ? MUS MUSCULUS 11 RASQDITNYLN 7 YTSRLHS 8 QQGKTLPT 5 GYGVN 16 MIWGDGRIDYNLVRKS 12 AYQRYDYYAMDY crystal 3.00A 22.10% FAB 31-MAR-17 20170331 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 10B9 MOLECULE: PEPTIDASE 1; SYNONYM: ALLERGEN DER P I, MAJOR MITE FECAL ALLERGEN DER P 1 ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPYT 5 SGFWN 16 YITYSGTSYYKPSLKS 14 RGFLTTVNYYAMDY crystal 2.74A 20.30% FAB 31-MAR-17 20170331 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FAB BINDING TO EXTRACELLULAR DOMAIN 5 OF CADHERIN - 6 MOLECULE: CADHERIN - 6; SYNONYM: KIDNEY CADHERIN,K - CADHERIN ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AVSTLQS 10 QQSGTFPPTT 5 SHGMH 17 VISGSGSNTGYADSVKG 9 QWGSYAFDS crystal 2.34A 21.40% FAB 04-APR-17 20170404 IMMUNE SYSTEM ALTERNATIVE MODEL FOR FAB 36 - 65 ? ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPRT 5 SYGIN 17 YINPGNGYTKYNEKFKG 12 SVYYGGSYYFDY crystal 2.50A 20.80% FAB 10-APR-17 20170410 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN FAB VRC38.01, AN HIV - 1 V1V2 - DIRECTED NEUTRALIZING ANTIBODY ISOLATED FROM DONOR N90, BOUND TO A SCAFFOLDED WITO V1V2 DOMAIN MOLECULE: 1FD6 - V1V2 - WITO; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLLLGNGRNYLD 7 LGSNRAS 10 MEARQTPRLT 5 DNDMH 16 SIGSSGDTYYIDAVKG 16 GPESGWFYHYYWGLGV crystal 3.46A 21.70% FAB 11-APR-17 20170411 IMMUNE SYSTEM FC FRAGMENT OF HUMAN IGG1 ANTIBODY, FROM NIST MAB ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.12A 20.30% FC 11-APR-17 20170411 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF THE ANTI - TNFA ANTIBODY INFLIXIMAB IN A C - CENTERED ORTHORHOMBIC CRYSTAL FORM ? ? ? MUS MUSCULUS 11 RASQFVGSSIH 7 YASESMS 9 QQSHSWPFT 5 NHWMN 19 EIRSKSINSATHYAESVKG 9 NYYGSTYDY crystal 2.00A 16.20% FAB 12-APR-17 20170412 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - TNFA ANTIBODY INFLIXIMAB IN AN I - CENTERED ORTHORHOMBIC CRYSTAL FORM ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQFVGSSIH 7 YASESMS 9 QQSHSWPFT 5 NHWMN 19 EIRSKSINSATHYAESVKG 9 NYYGSTYDY crystal 2.00A 15.90% FAB 12-APR-17 20170412 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FC FRAGMENT OF ANTI - TNFA ANTIBODY INFLIXIMAB ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS, HOMO SAPIENS; ORGANISM_TAXID: 10090, 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.75A 19.20% FC 12-APR-17 20170412 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - ZIKA ANTIBODY Z004 BOUND TO DENV - 1 ENVELOPE PROTEIN DIII MOLECULE: DENGUE 1 ENVELOPE DIII DOMAIN; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 RASQSISKWLA 7 TTSTLKS 9 QHFYSVPWT 5 DYAMS 17 SYSGIDDSTYYADSVKG 13 DRGPRGVGELFDS crystal 3.00A 23.70% FAB 14-APR-17 20170414 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - ZIKA ANTIBODY Z006 BOUND TO ZIKA VIRUS ENVELOPE PROTEIN DIII MOLECULE: ZIKA VIRUS ENVELOPE PROTEIN DIII; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 RASQTISGWLA 7 QASRLES 8 QQYSTFWT 5 NYAMA 17 LLYNSEESTYYADSVKG 11 DRSNGWSSINL crystal 3.00A 21.40% FAB 16-APR-17 20170416 VIRAL PROTEIN / IMMUNE SYSTEM BG505 SOSIP.664 IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES BG1 AND 8ANC195 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 509 - 661; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDRWSGLHHDGVMAFSS ElectronMicroscopy N/A N/A FAB 17-APR-17 20170417 VIRAL PROTEIN / IMMUNE SYSTEM BG505 SOSIP.664 IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES PG9 AND 8ANC195 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: UNP RESIDUES 509 - 661; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDRWSGLHHDGVMAFSS ElectronMicroscopy N/A N/A FAB 18-APR-17 20170418 HYDROLASE / IMMUNE SYSTEM COMPLEX BETWEEN HYHEL10 FAB FRAGMENT HEAVY CHAIN MUTANT I29F AND PEKIN DUCK EGG LYSOZYME ISOFORM I (DEL - I) MOLECULE: LYSOZYME ISOFORM I (DEL - I); ? ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.43A 26.40% FAB 19-APR-17 20170419 HYDROLASE / IMMUNE SYSTEM COMPLEX BETWEEN HYHEL10 FAB FRAGMENT HEAVY CHAIN MUTANT (I29F, S52T, Y53F) AND PEKIN DUCK EGG LYSOZYME ISOFORM I (DEL - I) MOLECULE: LYSOZYME; ? ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVTFSGSTYYNPSLKS 5 WDGDY crystal 1.90A 19.50% FAB 19-APR-17 20170419 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURAL BASIS FOR ANTIBODY - MEDIATED NEUTRALIZATION OF LASSA VIRUS MOLECULE: PRE - GLYCOPROTEIN POLYPROTEIN GP COMPLEX; FRAGMENT: UNP RESIDUES 1 - 259; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTGSDIGGYNFVS 7 EVRIRAS 10 NSYSIHSPWV 5 TYSMN 18 SISSRSGSHINYVDSVKG 13 DRRSGTSPLPLDV crystal 3.20A 19.10% FAB 20-APR-17 20170420 IMMUNE SYSTEM / TRANSPORT PROTEIN OPEN CONFORMATION OF KCSA NON - INACTIVATING E71A MUTANT MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.25A 18.70% ? 21-APR-17 20170421 IMMUNE SYSTEM CRYSTAL STRUCTURE OF C - TERMINAL DOMAIN OF EBOLA (BUNDIBUGYO) NUCLEOPROTEIN IN COMPLEX WITH FAB FRAGMENT MOLECULE: NUCLEOPROTEIN; ENGINEERED: YES; OTHER_DETAILS: FRAGMENT: C - TERMINAL DOMAIN (UNP RESIDUES 641 - 739) GENE NAME (S): NP DH33_45404GPNP; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.75A 17.70% FAB 21-APR-17 20170421 IMMUNE SYSTEM / TRANSPORT PROTEIN OPEN CONFORMATION OF KCSA DEEP - INACTIVATED MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.37A 19.70% ? 21-APR-17 20170421 IMMUNE SYSTEM / TRANSPORT PROTEIN CLOSED CONFORMATION OF KCSA Y82A - F103A MUTANT MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; SYNONYM: STREPTOMYCES LIVIDANS K+ CHANNEL,SKC1; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.25A 17.50% ? 21-APR-17 20170421 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - CD22 EPRATUZUMAB ? ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSVLYSANHKNYLA 7 WASTRES 8 HQYLSSWT 5 SYWLH 17 YINPRNDYTEYNQNFKD 7 RDITTFY crystal 2.01A 21.30% FAB 21-APR-17 20170421 UNKNOWN FUNCTION THE HAPTEN TRICLOCARBAN BOUND TO THE SINGLE DOMAIN CAMELID NANOBODY VHH T4 MOLECULE: T4 NANOBODY; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 HTPYA 17 VGGIGGVAATTTYADSV 17 ATRASMAVSTSPRVYPI crystal 1.90A 22.20% HC-dimer 24-APR-17 20170424 IMMUNE SYSTEM CD22 D1 - D3 IN COMPLEX WITH THERAPEUTIC FAB EPRATUZUMAB MOLECULE: B - CELL RECEPTOR CD22; SYNONYM: B - LYMPHOCYTE CELL ADHESION MOLECULE,BL - CAM,SIALIC ACID - BINDING IG - LIKE LECTIN 2,SIGLEC - 2,T - CELL SURFACE ANTIGEN LEU - 14; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSVLYSANHKNYLA 7 WASTRES 8 HQYLSSWT 5 SYWLH 17 YINPRNDYTEYNQNFKD 7 RDITTFY crystal 3.10A 28.10% FAB 24-APR-17 20170424 HYDROLASE PCSK9 COMPLEX WITH FAB33 MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; FRAGMENT: CATALYTIC AND CYSTEINE - RICH DOMAINS, RESIDUES 153 - 692; SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1,NARC - 1,PROPROTEIN CONVERTASE 9,PC9,SUBTILISIN / KEXIN - LIKE PROTEASE PC9; EC: 3.4.21. -; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQAYPALHT 5 STAIH 17 RISPANGNTNYADSVKG 12 WIGSRELYIMDY crystal 3.50A 20.10% FAB 25-APR-17 20170425 HYDROLASE PCSK9 COMPLEX WITH LDLR ANTAGONIST PEPTIDE AND FAB7G7 MOLECULE: LDLR ANTAGONIST PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 KTSQNVGTAVA 7 SASNRYT 9 HQYSSYPLT 5 DYYIN 17 RIYPGSGHTYYNENFKD 15 ENFYGSSYVDWYFDV crystal 2.90A 17.30% FAB 25-APR-17 20170425 UNKNOWN FUNCTION THE APO FORM OF THE TRICLOCARBAN - BINDING SINGLE DOMAIN CAMELID NANOBODY VHH T9 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 TPYAMA 17 AGIGGIDGTAAYADSVR 16 TRASMQVLTSPRVYPI crystal 1.35A 16.30% HC-dimer 26-APR-17 20170426 UNKNOWN FUNCTION THE HAPTEN TRICLOCARBAN BOUND TO THE SINGLE DOMAIN CAMELID NANOBODY VHH T9 MOLECULE: CAMELID NANOBODY VHH T9; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 TPYAMA 17 AGIGGIDGTAAYADSVR 16 TRASMQVLTSPRVYPI crystal 1.79A 20.60% HC-dimer 26-APR-17 20170426 UNKNOWN FUNCTION THE APO FORM OF THE TRICLOCARBAN - BINDING SINGLE DOMAIN CAMELID NANOBODY VHH T10 MOLECULE: SINGLE DOMAIN CAMELID NANOBODY VHH T10; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 LSSTIVG 17 GIAWSSSDTWYADSVKG 20 ALRRPGSDASDYTRIPDYPY crystal 1.90A 19.90% HC-dimer 26-APR-17 20170426 UNKNOWN FUNCTION THE HAPTEN TRICLOCARBAN BOUND TO THE SINGLE DOMAIN CAMELID NANOBODY VHH T10 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 7 LSSTIVG 17 GIAWSSSDTWYADSVKG 20 ALRRPGSDASDYTRIPDYPY crystal 1.50A 17.20% HC-dimer 26-APR-17 20170426 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG1 FC K248E, T437R MUTANT ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686C11235; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: EXPI293F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.10A 23.10% FC 27-APR-17 20170427 IMMUNE SYSTEM CRYO - EM MODEL OF B41 SOSIP.664 IN COMPLEX WITH SOLUBLE CD4 (D1 - D2) AND FRAGMENT ANTIGEN BINDING VARIABLE DOMAIN OF 17B MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH ElectronMicroscopy N/A N/A FAB 28-APR-17 20170428 IMMUNE SYSTEM CRYO - EM MODEL OF B41 SOSIP.664 IN COMPLEX WITH FRAGMENT ANTIGEN BINDING VARIABLE DOMAIN OF B12 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RSSHSIRSRRVA 7 GVSNRAS 9 QVYGASSYT 5 NFVIH 17 WINPYNGNKEFSAKFQD 18 VGPYSWDDSPQDNYYMDV ElectronMicroscopy N/A N/A FAB 28-APR-17 20170428 DE NOVO PROTEIN CRYSTAL STRUCTURE OF NB.B201 ? ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 AYYMG 16 TITHGTNTYYADSVKG 10 LETRSYSFRY crystal 1.40A 18.40% HC-dimer 01-MAY-17 20170501 TRANSPORT PROTEIN / DE NOVO PROTEIN CRYSTAL STRUCTURE OF NB.B201 BOUND TO HUMAN SERUM ALBUMIN MOLECULE: SERUM ALBUMIN; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 AYYMG 16 TITHGTNTYYADSVKG 10 LETRSYSFRY crystal 2.60A 22.20% HC-dimer 01-MAY-17 20170501 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HCMV PENTAMER IN COMPLEX WITH NEUTRALIZING ANTIBODY 8I21 MOLECULE: ENVELOPE GLYCOPROTEIN L; SYNONYM: GL; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 11 RASQSVGINLA 7 GASTRAS 10 QQYNDWPPWT 5 SDGMH 17 FISSDGSTPYYADSVKG 13 DWALFRWLRTFDH crystal 3.02A 19.20% FAB 02-MAY-17 20170502 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HCMV PENTAMER IN COMPLEX WITH NEUTRALIZING ANTIBODY 8I21 - LOW RESOLUTION DATASET FOR INITIAL PHASING BY SAD MOLECULE: ENVELOPE GLYCOPROTEIN L; SYNONYM: GL; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 11 RASQSVGINLA 7 GASTRAS 10 QQYNDWPPWT 5 SDGMH 17 FISSDGSTPYYADSVKG 13 DWALFRWLRTFDH crystal 3.99A 26.00% FAB 02-MAY-17 20170502 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HCMV PENTAMER IN COMPLEX WITH NEUTRALIZING ANTIBODY 9I6 MOLECULE: ENVELOPE GLYCOPROTEIN L; SYNONYM: GL; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLGYSDGNTYLN 7 EVSNRDS 11 MQGTHWPPMCS 5 AYWIA 17 IIYPIDSETTYSPSFQG 12 GTSTGLREAFHI crystal 5.90A 26.00% FAB 02-MAY-17 20170502 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1 MOLECULE: DER P 1 ALLERGEN; FRAGMENT: UNP RESIDUES 99 - 320; ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 1.95A 15.80% FAB 05-MAY-17 20170505 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1 MOLECULE: DER P 1 ALLERGEN; FRAGMENT: UNP RESIDUES 81 - 302; ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 2.50A 18.00% FAB 05-MAY-17 20170505 HYDROLASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF DER F 1 COMPLEXED WITH FAB 4C1 MOLECULE: DER F 1 VARIANT; FRAGMENT: UNP RESIDUES 99 - 321; ? ? MUS MUSCULUS 11 KASQDIYSYLS 7 RANRLIT 9 LQYDEFPYT 6 SDYAWN 16 YISYSGTTSYNPSLKS 12 TGVYRYPERAPY crystal 1.90A 15.40% FAB 05-MAY-17 20170505 TOXIN / IMMUNE SYSTEM CLOSTRIDIUM DIFFICILE TCDB - GTD BOUND TO PA41 FAB MOLECULE: TOXIN B; FRAGMENT: TCDB GLUCOSYLTRANSFERASE DOMAIN RESIDUES 1 - 544; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVGTSIH 7 FASESIS 9 QQSNKWPFT 5 NYFMH 17 RINPYNGATSYSLNFRD 10 STITSPLLDF crystal 2.79A 24.20% FAB 09-MAY-17 20170509 IMMUNE SYSTEM CH1 / CKAPPA FAB BASED ON MATUZUMAB ? KAPPA ? HOMO SAPIENS 10 SASSSVTYMY 7 DTSNLAS 9 QQWSSHIFT 5 SHWMH 17 EFNPSNGRTNYNEKFKS 12 RDYDYDGRYFDY crystal 2.15A 21.20% FAB 10-MAY-17 20170510 IMMUNE SYSTEM CH1 / CLAMBDA FAB BASED ON PERTUZUMAB ? LAMBDA ? HOMO SAPIENS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQRFKG 10 NLGPSFYFDY crystal 2.55A 20.90% FAB 11-MAY-17 20170511 IMMUNE SYSTEM CH1 / CKAPPA FAB MUTANT 15.1 ? KAPPA ? HOMO SAPIENS 10 SASSSVTYMY 7 DTSNLAS 9 QQWSSHIFT 5 SHWMH 17 EFNPSNGRTNYNEKFKS 12 RDYDYDGRYFDY crystal 1.51A 19.50% FAB 11-MAY-17 20170511 HYDROLASE CO - CRYSTAL STRUCTURE OF DPPIV WITH A CHEMIBODY INHIBITOR MOLECULE: DIPEPTIDYL PEPTIDASE 4; FRAGMENT: RESIDUES 37 - 767; SYNONYM: BILE CANALICULUS DOMAIN - SPECIFIC MEMBRANE GLYCOPROTEIN, DIPEPTIDYL PEPTIDASE IV,DPP IV,GP110 GLYCOPROTEIN,T - CELL ACTIVATION ANTIGEN CD26; EC: 3.4.14.5; ENGINEERED: YES; ? ? MUS MUSCULUS 10 RASSSVCNMH 7 GTSNLAS 9 QQWSNHPPT 5 DYNIN 17 VVIPKYGTTNYNQKFQG 7 FRVFFDV crystal 2.80A 25.20% FAB 16-MAY-17 20170516 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN AFUCOSYLATED / GALACTOSYLATED HUMAN IGG1 FC AND FC GAMMA RECEPTOR IIIA (CD16A) WITH MAN5 N - GLYCANS ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293-F; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293-F 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.26A 19.40% FC 18-MAY-17 20170518 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 354BG1 FAB MOLECULE: 354BG1 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASHFIANYVN 7 ESSTLQR 9 QQSHSPPVT 5 DYAMA 19 FMRGWAYGGSAQFAAFAVG 22 EQRNKDYRYGQEGFGYSYGMDV crystal 2.00A 21.40% FAB 19-MAY-17 20170519 IMMUNE SYSTEM 2.50 A RESOLUTION STRUCTURE OF IPAD FROM SHIGELLA FLEXNERI IN COMPLEX WITH SINGLE - DOMAIN ANTIBODY JMK - E3 MOLECULE: INVASIN IPAD; SYNONYM: 36 KDA MEMBRANE ANTIGEN; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 RAVMN 17 RIYDAGGNGSIADPVKG 10 GIFDGNYRTY crystal 2.50A 20.00% HC-dimer 23-MAY-17 20170523 IMMUNE SYSTEM 2.55 A RESOLUTION STRUCTURE OF IPAD FROM SHIGELLA FLEXNERI IN COMPLEX WITH SINGLE - DOMAIN ANTIBODY JMK - H2 MOLECULE: INVASIN IPAD; SYNONYM: 36 KDA MEMBRANE ANTIGEN; ENGINEERED: YES; MUTATION: YES ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 DQPIA 17 CISIDGNTQSYSDSVKG 19 DRYTSVRQMCTMIEGLHRV crystal 2.55A 20.50% HC-dimer 23-MAY-17 20170523 IMMUNE SYSTEM 2.80 A RESOLUTION STRUCTURE OF IPAD FROM SHIGELLA FLEXNERI IN COMPLEX WITH SINGLE - DOMAIN ANTIBODY JPS - G3 MOLECULE: INVASIN IPAD; SYNONYM: 36 KDA MEMBRANE ANTIGEN; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 IYNMG 18 SIDSYSGSITNYADSVKG 7 NLRTNNY crystal 2.80A 20.50% HC-dimer 23-MAY-17 20170523 IMMUNE SYSTEM 2.05 A RESOLUTION STRUCTURE OF IPAD FROM SHIGELLA FLEXNERI IN COMPLEX WITH SINGLE - DOMAIN ANTIBODY 20IPAD MOLECULE: INVASIN IPAD; SYNONYM: 36 KDA MEMBRANE ANTIGEN; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 SHAIG 17 CINDDGSTTRYADSVKG 16 KSVWFCSVIRSHEFNS crystal 2.05A 21.20% HC-dimer 23-MAY-17 20170523 IMMUNE SYSTEM THE ANTIGEN - BINDING FRAGMENT OF MAB24 IN COMPLEX WITH A PEPTIDE FROM HEPATITIS C VIRUS E2 EPITOPE I (412 - 423) MOLECULE: VIRUS ENVELOPE PROTEIN 2; FRAGMENT: EPITOPE I (UNP RESIDUES 412 - 423); ENGINEERED: YES ? ? MUS MUSCULUS 15 RASESVDSYGKSFLH 7 LASNLES 9 QHNNEDPWT 5 SGYWN 17 GYISYSGDTYYNPSLKS 11 MGYGSQPGFGS crystal 1.40A 17.20% ? 24-MAY-17 20170524 IMMUNE SYSTEM STRUCTURE OF SINGLE CHAIN FEL D 1 BOUND TO A NEUTRALIZING ANTIBODY MOLECULE: CHIMERA OF MAJOR ALLERGEN I POLYPEPTIDE CHAIN 2,MAJOR ALLERGEN I POLYPEPTIDE CHAIN 1; FRAGMENT: UNP P30440 RESIDUES 18 - 109, UNP P30438 23 - 92; SYNONYM: AG4,ALLERGEN CAT - 1,ALLERGEN FEL D I - B,ALLERGEN FDI,AG4, ALLERGEN CAT - 1,ALLERGEN FEL D I - A,ALLERGEN FEL DI; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSISSWLA 7 KASSLES 9 QQYNSYPLT 5 SYAMS 17 AISGRGYNADYADSVKG 6 LEYFDY crystal 2.90A 22.70% FAB 25-MAY-17 20170525 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE APO ANTIBODY FRAGMENT (FAB) RAISED AGAINST C - TERMINAL DOMAIN OF EBOLA NUCLEOPROTEIN (EBOV, TAFV, BDBV STRAINS) ? ? ? HOMO SAPIENS 11 RASQSVSSAVA 0 9 QQYSYSLVT 5 YYYIH 17 SISPYYGYTSYADSVKG 8 WSYSGMDY crystal 2.11A 22.00% FAB 26-MAY-17 20170526 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MERS - COV NEUTRALIZING ANTIBODY G4 FAB ? ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 0 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY crystal 1.57A 18.40% FAB 29-MAY-17 20170529 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CRENEZUMAB FAB ? ? ? HOMO SAPIENS 16 RSSQSLVYSNGDTYLH 7 KVSNRFS 9 SQSTHVPWT 5 SYGMS 17 SINSNGGSTYYPDSVKG 3 GDY crystal 2.50A 18.70% FAB 29-MAY-17 20170529 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CRENEZUMAB FAB IN COMPLEX WITH ABETA MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: UNP RESIDUES 682 - 696; SYNONYM: ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AMYLOID PRECURSOR PROTEIN,BETA - AMYLOID PRECURSOR PROTEIN,CEREBRAL VASCULAR AMYLOID PEPTIDE,CVAP,PREA4,PROTEASE NEXIN - II,PN - II; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSLVYSNGDTYLH 7 KVSNRFS 9 SQSTHVPWT 5 SYGMS 17 SINSNGGSTYYPDSVKG 3 GDY crystal 2.32A 20.80% FAB 29-MAY-17 20170529 IMMUNE SYSTEM ANTI - TISSUE FACTOR ANTIBODY M59, A HUMANIZED VERSION OF 10H10 ? ? ? MUS MUSCULUS 17 KSSQSLLSSGNQKNYLT 7 WASTRES 9 QNDYTYPLT 5 TYWIE 17 DILPGSGSTNYSPSFQG 11 SGYYGNSGFAY crystal 1.64A 18.80% FAB 30-MAY-17 20170530 IMMUNE SYSTEM HUMAN TISSUE FACTOR IN COMPLEX WITH ANTIBODY M1587 MOLECULE: TISSUE FACTOR; FRAGMENT: EXTRACELLULAR DOMAIN (UNP RESIDUES 37 - 245); SYNONYM: TF,COAGULATION FACTOR III,THROMBOPLASTIN; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLSSGNQKNYLT 7 WASTRES 9 QNDYTYPLT 5 PYWIE 17 DILPGSGFTTYSPSFQG 11 SGYYGNSGFAY crystal 2.60A 18.80% FAB 30-MAY-17 20170530 VIRAL PROTEIN / IMMUNE SYSTEM A / TEXAS / 50 / 2012 (H3N2) INFLUENZA HEMAGGLUTININ IN COMPLEX WITH K03.12 FAB MOLECULE: HEMAGGLUTININ HA1; FRAGMENT: UNP RESIDUES 53 - 335; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTNSDVGTFDLVS 7 EGSRRPS 8 SSYAGSVV 5 AYYLH 17 WINPNTGDTNYAQKFQG 24 DLTLMYVFDSGWARGAHDYYGMDV crystal 2.60A 24.10% FAB 30-MAY-17 20170530 VIRAL PROTEIN / IMMUNE SYSTEM INFERRED PRECURSOR (UCA) OF THE HUMAN ANTIBODY LINEAGE K03.12 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ H1 SOLOMON ISLANDS / 03 / 2006 MOLECULE: HEMAGGLUTININ HA1; FRAGMENT: UNP RESIDUES 73 - 288; ENGINEERED: YES; ? ? HOMO SAPIENS 6 TGNLVS 7 EGSKRPS 8 CSYAGSVV 5 GYYMH 17 WINPNSGGTNYAQKFQG 24 DLTLMYVHSSGWERGVYYYYGMDV crystal 1.90A 19.80% ? 30-MAY-17 20170530 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF EBV GHGL / CL40 / GP42 N - DOMAIN MOLECULE: ENVELOPE GLYCOPROTEIN L; FRAGMENT: UNP RESIDUES 24 - 137; SYNONYM: GL; ENGINEERED: YES; ? IGG MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRYS 9 QQYNSYPYT 5 DYWMH 17 AIDTSDSYTSYNQKFKG 7 GLLPFDY crystal 3.10A 24.50% ? 31-MAY-17 20170531 IMMUNE SYSTEM CR1 - 07 UNLIGANDED FAB ? ? ? HOMO SAPIENS 17 KSSQSVLYSSRSDNKDY 7 IYWASTR 11 YCQQYYSSPPT 5 TSIMH 17 QISHDESRKFYSDSVKG 15 DLSPPYSYAWDIFQY crystal 2.00A 23.30% FAB 03-JUN-17 20170603 VIRAL PROTEIN / IMMUNE SYSTEM JUNV GP1 CR1 - 10 FAB CR1 - 28 FAB COMPLEX MOLECULE: PRE - GLYCOPROTEIN POLYPROTEIN GP COMPLEX; FRAGMENT: UNP RESIDUES 87 - 228; SYNONYM: PRE - GP - C; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASGRAT 9 QQYGRSGYT 5 SSAMH 17 VIWSDGSNENYADSVKG 17 DKTYVSGYTSTWYYFNY crystal 3.99A 23.90% FAB 03-JUN-17 20170603 VIRAL PROTEIN / IMMUNE SYSTEM MACV GP1 CR1 - 07 FAB COMPLEX MOLECULE: PRE - GLYCOPROTEIN POLYPROTEIN GP COMPLEX; FRAGMENT: UNP RESIDUES 87 - 238; SYNONYM: MACV GP1; ENGINEERED: YES ? ? HOMO SAPIENS 17 KSSQSVLYSSRSDNKDY 7 IYWASTR 11 YCQQYYSSPPT 5 TSIMH 17 QISHDESRKFYSDSVKG 15 DLSPPYSYAWDIFQY crystal 3.91A 24.90% FAB 03-JUN-17 20170603 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF RSV F IN COMPLEX WITH 5C4 FAB MOLECULE: FUSION GLYCOPROTEIN F0; FRAGMENT: UNP RESIDUES 1 - 513; SYNONYM: PROTEIN F; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDSFDNSFIH 7 LASSLES 9 QQSNEDPFT 5 DTFFH 17 RIDPADGHTKYDPKFQG 15 TITAVVPTPYNAMDY crystal 3.40A 20.00% FAB 05-JUN-17 20170605 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 5C4 FAB ? ? ? MUS MUSCULUS 15 RASESVDSFDNSFIH 7 LASSLES 9 QQSNEDPFT 5 DTFFH 17 RIDPADGHTKYDPKFQG 10 TITPYNAMDY crystal 1.50A 17.10% FAB 05-JUN-17 20170605 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF C - TERMINAL DOMAIN OF EBOLA (RESTON) NUCLEOPROTEIN IN COMPLEX WITH FAB FRAGMENT MOLECULE: NUCLEOPROTEIN; SYNONYM: NUCLEOCAPSID PROTEIN,PROTEIN N; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSSSLIT 5 YSSIH 17 SIYSYSGYTSYADSVKG 16 SYWYHVGSWHYTGMDY crystal 2.25A 20.10% FAB 06-JUN-17 20170606 IMMUNE SYSTEM 1.80A RESOLUTION STRUCTURE OF HUMAN IGG3 FC (N392K) ? ? IGG3 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG3; EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS; EXPRESSION_SYSTEM_TAXID: 4922; EXPRESSION_SYSTEM_STRAIN: SMD1168; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PPICZALPHAA 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.80A 18.60% FC 07-JUN-17 20170607 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF RHINOVIRUS B14 IN COMPLEX WITH C5 FAB (33 DEGREES CELSIUS, MOLAR RATIO 1:3, FULL PARTICLE) MOLECULE: VIRAL PROTEIN 3; FRAGMENT: UNP RESIDUES 332 - 567; ? ? MUS MUSCULUS 11 RASGNIHNALA 7 AAAALAA 9 QHFWSTPYT 5 AYGVA 16 AIWAAGATDYNAALKS 8 EWDAYGDY ElectronMicroscopy N/A N/A FAB 07-JUN-17 20170607 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF RHINOVIRUS B14 IN COMPLEX WITH C5 FAB (4 DEGREES CELSIUS, MOLAR RATIO 1:3, FULL PARTICLE) MOLECULE: VIRAL PROTEIN 3; FRAGMENT: UNP RESIDUES 332 - 567; ? ? MUS MUSCULUS 11 RASGNIHNALA 7 AAAALAA 9 QHFWSTPYT 5 AYGVA 16 AIWAAGATDYNAALKS 8 EWDAYGDY ElectronMicroscopy N/A N/A FAB 08-JUN-17 20170608 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF RHINOVIRUS B14 IN COMPLEX WITH C5 FAB (33 DEGREES CELSIUS, MOLAR RATIO 1:1, FULL PARTICLE) MOLECULE: VIRAL PROTEIN 3; FRAGMENT: UNP RESIDUES 332 - 567; ? ? MUS MUSCULUS 11 RASGNIHNALA 7 AAAALAA 9 QHFWSTPYT 5 AYGVA 16 AIWAAGATDYNAALKS 8 EWDAYGDY ElectronMicroscopy N/A N/A FAB 08-JUN-17 20170608 VIRUS LIKE PARTICLE / IMMUNE SYSTEM CRYOEM STRUCTURE OF RHINOVIRUS B14 IN COMPLEX WITH C5 FAB (33 DEGREES CELSIUS, MOLAR RATIO 1:3, EMPTY PARTICLE) MOLECULE: VIRAL PROTEIN 3; FRAGMENT: UNP RESIDUES 332 - 567; ? ? MUS MUSCULUS 11 RASGNIHNALA 7 AAAALAA 9 QHFWSTPYT 5 AYGVA 16 AIWAAGATDYNAALKS 8 EWDAYGDY ElectronMicroscopy N/A N/A FAB 08-JUN-17 20170608 IMMUNE SYSTEM ANTIBODY C706 IN COMPLEX WTH BETA - AMYLOID PEPTIDE 1 - 16 MOLECULE: AMYLOID BETA A4 PROTEIN; FRAGMENT: RESIDUES 1 - 16; SYNONYM: ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AMYLOID PRECURSOR PROTEIN,BETA - AMYLOID PRECURSOR PROTEIN,CEREBRAL VASCULAR AMYLOID PEPTIDE,CVAP,PREA4,PROTEASE NEXIN - II,PN - II; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DSSRLAS 8 QNWRSSPT 5 TSWIE 17 EVLPGSGKSNHNANFKG 10 EGSNNNALAY crystal 1.92A 19.90% FAB 08-JUN-17 20170608 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN MONOCLONAL ANTIBODY H3V - 47 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A / MINNESOTA / 11 / 2010 (H3N2) MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 346 - 519; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RTSQGVSSSYLA 7 GSSSRAT 8 QQYATSPT 5 SYSIT 17 GIFPIFGSTNYAQKFDD 18 GASKVEPAAPAYSDAFDM crystal 3.57A 19.80% FAB 08-JUN-17 20170608 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NON - NEUTRALIZING AND ADCC - POTENT C11 - LIKE ANTIBODY N12 - I3 IN COMPLEX WITH HIV - 1 CLADE A / E GP120, THE CD4 MIMETIC M48U1, AND THE ANTIBODY N5 - I5. MOLECULE: CD4 MIMETIC PEPTIDE M48U1; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASRTVSSSNLA 7 DVSSRAT 9 QQYGTSPLT 5 RYTVN 17 RFIPIFNMPDYAPKFQG 9 RQHHEYFQE crystal 2.92A 23.40% FAB 12-JUN-17 20170612 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG1 - SIGMA FC FRAGMENT ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 19.40% FC 15-JUN-17 20170615 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG4 - SIGMA1 FC FRAGMENT ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG4; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: EXPI293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.90A 18.40% FC 15-JUN-17 20170615 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG4 - SIGMA2 FC FRAGMENT ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG4; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.85A 18.30% FC 15-JUN-17 20170615 APOPTOSIS / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BAXP168G IN COMPLEX WITH AN ACTIVATING ANTIBODY MOLECULE: APOPTOSIS REGULATOR BAX; SYNONYM: BCL - 2 - LIKE PROTEIN 4,BCL2 - L - 4; ENGINEERED: YES; MUTATION: YES ? ? RATTUS NORVEGICUS 11 KASQNVNKYLD 7 HTNSLPT 8 LQHDSGLT 5 NYDMH 17 WIYPGNGNTKYNQKFNG 9 EGLGITFEY crystal 2.50A 19.00% FAB 16-JUN-17 20170616 APOPTOSIS CRYSTAL STRUCTURE OF BAXP168G IN COMPLEX WITH AN ACTIVATING ANTIBODY AT HIGH RESOLUTION MOLECULE: APOPTOSIS REGULATOR BAX; FRAGMENT: UNP RESIDUES 32 - 192; SYNONYM: BCL - 2 - LIKE PROTEIN 4,BCL2 - L - 4; ENGINEERED: YES; MUTATION: YES ? ? RATTUS NORVEGICUS 11 KASQNVNKYLD 7 HTNSLPT 8 LQHDSGLT 5 NYDMH 17 WIYPGNGNTKYNQKFNG 9 EGLGITFEY crystal 2.00A 21.90% FAB 16-JUN-17 20170616 IMMUNE SYSTEM UCA FAB (UNBOUND) FROM 6649 LINEAGE ? ? ? HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GNSNRPS 12 QSYDSSLSGDMV 7 SSSYYWG 16 SIYYSGSTYYNPSLKS 15 SYVDNWHSGLHWFDP crystal 1.63A 17.80% FAB 16-JUN-17 20170616 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BG505 - SOSIP.V4.1 - GT1 - N137A IN COMPLEX WITH FABS 35022 AND 9H / 109L MOLECULE: BG505 - SOSIP.V4.1 - GT1 - N137A GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.20A 24.40% FAB 16-JUN-17 20170616 VIRAL PROTEIN / IMMUNE SYSTEM HUMAN ANTIBODY 6649 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ H1 SOLOMON ISLANDS MOLECULE: HEMAGGLUTININ HA2; FRAGMENT: UNP RESIDUES 344 - 519; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTHSNIGAGFDVH 7 ANNNRPS 12 QSFDSILSGDLV 7 NKDFFWA 16 SVFYSGGAYYNWSLRN 15 SYVDNWHAGLHWFDS crystal 2.79A 22.00% FAB 16-JUN-17 20170616 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: MERS S; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: MERS S; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 VIRAL PROTEIN MERS S ECTODOMAIN TRIMER IN COMPLEX WITH VARIABLE DOMAIN OF NEUTRALIZING ANTIBODY G4 MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 ATSNQGS 9 QQSKEVPRT 5 DYAIH 17 VFSTYYGNTNYNQKFKG 13 KSYYVDYVDAMDY ElectronMicroscopy N/A N/A ? 23-JUN-17 20170623 IMMUNE SYSTEM FC ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION - MAKING IN ANTIBODY DRUG DISCOVERY. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 22.10% FC 27-JUN-17 20170627 IMMUNE SYSTEM FCABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION - MAKING IN ANTIBODY DRUG DISCOVERY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.25A 23.40% FC 27-JUN-17 20170627 MEMBRANE PROTEIN LIGAND - FREE US28 WITH STABILIZING INTRACELLULAR NANOBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HUMAN CYTOMEGALOVIRUS, LAMA GLAMA; ORGANISM_COMMON: HHV-5, LLAMA; ORGANISM_TAXID: 10359, 9844; GENE: US28; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.51A 24.70% ? 27-JUN-17 20170627 MEMBRANE PROTEIN US28 BOUND TO ENGINEERED CHEMOKINE CX3CL1.35 AND NANOBODIES MOLECULE: CX3CL1 PROTEIN; SYNONYM: ENGINEERED CHEMOKINE CX3CL1.35; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 YYAIG 17 CISTSVGSTKYADSVKG 21 DLSTFYGGNYYCGDRGIYDYY crystal 3.50A 25.60% HC-dimer 27-JUN-17 20170627 VIRAL PROTEIN CRYSTAL STRUCTURE OF CD4 BINDING SITE ANTIBODY N60P23 IN COMPLEX WITH HIV - 1 CLADE A / E STRAIN 93TH057 GP120 CORE MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RSSQSGWKA 7 KSSILET 5 QHFET 5 NYFIH 17 WMNPLHGGVNYSGRFQG 11 GRDGYDDGFHP crystal 2.40A 21.60% FAB 28-JUN-17 20170628 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING INFLUENZA A ANTIBODY VRC 315 27 - 1C08 FAB. ? ? ? HOMO SAPIENS 14 TRTAAAVTSYNYVS 7 EVSNRPS 10 CSSTSSTTVV 5 GNYVH 17 WINPKSDGTNYAQKFQG 16 DKGLRYFDWLSGGMDV crystal 1.37A 16.60% FAB 29-JUN-17 20170629 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING INFLUENZA A ANTIBODY VRC 315 02 - 1F07 FAB. ? ? ? HOMO SAPIENS 14 TGTRSDIDGYNYVS 7 EVNKRPS 11 SSYTDTNNFYV 5 GNYMT 16 IIYTGGSTYYADSVKG 16 ALKLQFFDWPSHAFDI crystal 2.46A 20.50% FAB 29-JUN-17 20170629 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BROADLY NEUTRALIZING INFLUENZA A ANTIBODY VRC 315 04 - 1D02 FAB. ? ? ? HOMO SAPIENS 14 TGTRSDIGAYSYVS 7 EVNKRPS 11 SSYAGDKNFVL 5 SNFMH 16 VIFKGGTAYYADSVRG 16 DGGLRFLDWPRWGMDV crystal 1.81A 17.90% FAB 29-JUN-17 20170629 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 10E8V4 - 5R+100CF FAB IN COMPLEX WITH HIV - 1 GP41 PEPTIDE MOLECULE: HIV - 1 GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RGDSLRSHYAS 7 GKNNRPS 12 SSRDKSGSRLSV 5 NAWMT 19 RITGPGEGWSVDYAESVKG 20 TGKYYDFWFGYPPGEEYFQD crystal 3.10A 24.90% FAB 05-JUL-17 20170705 IMMUNE SYSTEM HIV - 1 ENV BG505 SOSIP.664 H72C - H564C TRIMER IN COMPLEX WITH BNABS PGT122 FAB, 35O22 FAB AND NIH45 - 46 SCFV MOLECULE: BNAB NIH45 - 46 SCFV LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GEESLGSRSVI 7 NNNDRPS 15 YYCHIWDSRRPTNWV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 7.00A 30.40% FV 06-JUL-17 20170706 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF A MR78 MUTANT MOLECULE: MR78 MUTANT LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQVISNYLN 7 DTSNLKT 9 QQYENLQFT 7 SSSFYWG 16 SVYYSGGASYNPSLKS 15 IYGSGTFYYYFYMDV crystal 2.00A 18.70% FAB 10-JUL-17 20170710 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - FCRN ANTIBODY DX - 2507 ? ? ? HOMO SAPIENS 14 TGTGSDVGSYNLVS 7 GDSQRPS 10 ASYAGSGIYV 5 EYAMG 17 SIGSSGGQTKYADSVKG 7 LAIGDSY crystal 2.15A 18.20% FAB 17-JUL-17 20170717 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTIBODY DX - 2507 BOUND TO FCRN - B2M ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGRT, FCRN; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; EXPRESSION_SYSTEM_TAXID: 7108; MOL_ID: 4; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: B2M, CDABP0092, HDCMA22P; EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; EXPRESSION_SYSTEM_TAXID: 7108 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 17.20% FC 17-JUL-17 20170717 IMMUNE SYSTEM PGDM1400 - 10E8V4 CODV FAB ? ? ? HOMO SAPIENS 16 KSSHSLIHGDRNNYLA 7 LASSRAS 15 MQGRESPWTFGQGTK 5 NAWMT 19 RITGPGEGWSVDYAESVKG 26 TGKYYDFWSGYPPGEEYFQDWGQGTL crystal 3.55A 24.20% FAB 18-JUL-17 20170718 STRUCTURAL PROTEIN CRYSTAL STRUCTURE OF KL WITH AN AGONIST FAB MOLECULE: BETA - KLOTHO; SYNONYM: BETAKLOTHO,KLOTHO BETA - LIKE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSTYLA 7 GASSRAT 9 QQSGSSPLT 5 NYGIH 17 VIWYDGSIKYYADSVKG 15 DRAAAGLHYYYGMDV crystal 2.70A 21.80% FAB 18-JUL-17 20170718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - CCL17 ANTIBODY M116 MOLECULE: M116 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 17 KSSQSVLLSPWNSNQLA 7 GASTRES 9 QQYYLIPST 5 SYWIG 17 IIDPSDSDTRYSPSFQG 12 VGPADVWDSFDY crystal 1.50A 18.00% ? 24-JUL-17 20170724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB MOLECULE: C - C MOTIF CHEMOKINE 17; FRAGMENT: UNP RESIDUES 24 - 94; SYNONYM: CC CHEMOKINE TARC,SMALL - INDUCIBLE CYTOKINE A17,THYMUS AND ACTIVATION - REGULATED CHEMOKINE; ENGINEERED: YES; OTHER_DETAILS: G7T MUTANT OF HUMAN CCL17 ? ? HOMO SAPIENS 17 KSSQSVLLSPWNSNQLA 7 GASTRES 9 QQYYLIPST 5 SYWIG 17 IIDPSDSDTRYSPSFQG 12 VGPADVWDSFDY crystal 1.90A 18.10% FAB 24-JUL-17 20170724 ANTIVIRAL PROTEIN CRYSTAL STRUCTURE OF ANTIBODY 27F3 RECOGNIZING THE HA FROM A / CALIFORNIA / 04 / 2009 (H1N1) INFLUENZA VIRUS MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYVSTPLT 5 NYAIN 17 GISPIFGPPKYAQKFQG 14 KLEPPYYFYSYMDV crystal 3.49A 24.70% ? 25-JUL-17 20170725 IMMUNE SYSTEM VH1 - 69 GERMLINE ANTIBODY PREDICTED FROM CR6261 MOLECULE: LAMBDA - CHAIN (AA - 20 TO 215); ENGINEERED: YES LAMBDA ? HOMO SAPIENS 13 SGSSSNIGNNYVS 7 DNNKRPS 12 GTWDSSLSAYVV 5 SYAIS 17 GIIPIFGTANYAQKFQG 12 HMGYQLRETMDV crystal 1.85A 20.60% ? 25-JUL-17 20170725 ANTIVIRAL PROTEIN VH1 - 69 GERMLINE ANTIBODY WITH CDR H3 SEQUENCE OF CR9114 MOLECULE: GERMLINE - REVERTED LIGHT CHAIN OF CR9114; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSSSNIGNNAVN 7 YDDLLPS 11 AAWDDSLNGAV 3 AIS 17 GIIPIFGTANYAQKFQG 12 HGNYYYYSGMDV crystal 2.00A 20.20% ? 25-JUL-17 20170725 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF ANTIBODY 2D10 BOUND TO THE CENTRAL CONSERVED REGION OF RSV G MOLECULE: MAJOR SURFACE GLYCOPROTEIN G; FRAGMENT: CENTRAL CONSERVED REGION OF RSV G, UNP RESIDUES 168 - 196; SYNONYM: ATTACHMENT GLYCOPROTEIN G,MEMBRANE - BOUND GLYCOPROTEIN,MG; ENGINEERED: YES ? ? HOMO SAPIENS 17 KASGYVFTNYGVSWVRQ 7 NGNTYYA 15 YYCGRDMLGVVQAVA 5 NYGVS 17 WSSPYNGNTYYAQKLKA 26 DMLGVVQAVAGPFDSWGQGTLVTVSS crystal 1.55A 17.00% scFv 31-JUL-17 20170731 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF ANTIBODY 3D3 BOUND TO THE CENTRAL CONSERVED REGION OF RSV G MOLECULE: MAJOR SURFACE GLYCOPROTEIN G; FRAGMENT: CENTRAL CONSERVED REGION OF RSV G, UNP RESIDUES 161 - 197; SYNONYM: ATTACHMENT GLYCOPROTEIN G,MEMBRANE - BOUND GLYCOPROTEIN,MG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSNHLA 7 ETSNRAT 8 QQRNNWYT 5 EHAMH 17 GISWNSGSVGYADSVKG 15 MVATTKNDFHYYKDV crystal 2.40A 19.40% FAB 31-JUL-17 20170731 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF ANTIBODY 3D3 BOUND TO THE LINEAR EPITOPE OF RSV G MOLECULE: MAJOR SURFACE GLYCOPROTEIN G; FRAGMENT: CENTRAL CONSERVED REGION OF RSV G, UNP RESIDUES 162 - 172; SYNONYM: ATTACHMENT GLYCOPROTEIN G,MEMBRANE - BOUND GLYCOPROTEIN,MG; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSNHLA 7 ETSNRAT 8 QQRNNWYT 4 HAMH 17 GISWNSGSVGYADSVKG 15 MVATTKNDFHYYKDV crystal 2.40A 22.60% FAB 31-JUL-17 20170731 HYDROLASE CRYSTAL STRUCTURE ANALYSIS OF FAB1 - BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INSULIN MOLECULE: INSULIN - DEGRADING ENZYME; FRAGMENT: UNP RESIDUES 42 - 1019; SYNONYM: ABETA - DEGRADING PROTEASE,INSULIN PROTEASE,INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; ? ? MUS MUSCULOIDES 11 RASQSVSSAVA 7 STSSLYS 10 QQSSPSFLIT 5 SYSIH 17 SISSYYGSTSYADSVKG 20 DRVMYYWSFSKYGYPYGMDY crystal 3.95A 24.40% FAB 01-AUG-17 20170801 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - HAV ANTIBODY R10 ? ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSRLAF 8 QQWSSNYT 5 TYGMS 17 TISGGGGYTYYPDSVKG 12 RVTTVAEYYFDY crystal 2.91A 20.40% FAB 11-DEC-16 20161211 VIRUS CRYO - EM STRUCTURE FOR HEPATITIS A VIRUS COMPLEXED WITH FAB MOLECULE: VP2; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSRLAF 8 QQWSSNYT 5 TYGMS 17 TISGGGGYTYYPDSVKG 12 RVTTVAEYYFDY ElectronMicroscopy N/A N/A FAB 12-DEC-16 20161212 PROTEIN BINDING STRUCTURE OF THE 093G9 FAB IN COMPLEX WITH THE EPITOPE PEPTIDE MOLECULE: EPITOPE PEPTIDE OF CYR61; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLYSDGKTYLN 7 LVSKLDS 9 VQGTHFPQT 6 SDYSWH 16 YIHYSGSTNYNPSLKS 10 GTIYEGSLDY crystal 2.70A 22.50% FAB 14-DEC-16 20161214 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CERTOLIZUMAB FAB MOLECULE: LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 KASQNVGTNVA 7 SASFLYS 9 QQYNIYPLT 5 DYGMN 17 WINTYIGEPIYADSVKG 9 GYRSYAMDY crystal 1.95A 14.90% FAB 21-DEC-16 20161221 IMMUNE SYSTEM TNFALPHA - CERTOLIZUMAB FAB MOLECULE: TUMOR NECROSIS FACTOR ALPHA; FRAGMENT: UNP RESIDUES 76 - 232; ENGINEERED: YES ? ? HOMO SAPIENS 11 KASQNVGTNVA 7 SASFLYS 9 QQYNIYPLT 5 DYGMN 17 WINTYIGEPIYADSVKG 9 GYRSYAMDY crystal 2.90A 22.80% FAB 21-DEC-16 20161221 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI - CONNEXIN26 SCFV ? ? ? HOMO SAPIENS, SYNTHETIC CONSTRUCT Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.65A 23.70% scFv 13-JAN-17 20170113 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTI - HIV - 1 ANTIBODY 4E10, MUTANT NPRO, WITH PEPTIDE BOUND MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGNNKLA 7 GASSRPS 9 QQYGQSLST 5 TYALS 17 GVIPLLTITNYAPRFQG 14 EGTTPGKPIGAFAH crystal 1.49A 13.00% FAB 20-JAN-17 20170120 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CD147 C2 DOMAIN IN COMPLEX WITH FAB OF ITS MONOCLONAL ANTIBODY 6H8 MOLECULE: BASIGIN; FRAGMENT: C2 DOMAIN, UNP RESIDUES 22 - 101; SYNONYM: CD147; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 9 GQSYSYPFT 5 NFWMN 19 EIRLKSNNYATHYAESVKG 5 YDYEY crystal 2.50A 24.90% FAB 23-JAN-17 20170123 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MEDAKA FISH TASTE RECEPTOR T1R2A - T1R3 LIGAND BINDING DOMAINS IN COMPLEX WITH L - GLUTAMINE MOLECULE: TASTE RECEPTOR, TYPE 1, MEMBER 3; FRAGMENT: UNP RESIDUES 12 - 483; SYNONYM: T1R3; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQTNEDPRT 5 GYSMN 17 LINPYNGDTTYKQKFKG 15 SGRGAPTTTTAWFTY crystal 2.21A 17.60% FAB 02-FEB-17 20170202 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MEDAKA FISH TASTE RECEPTOR T1R2A - T1R3 LIGAND BINDING DOMAINS IN COMPLEX WITH L - ALANINE MOLECULE: TASTE RECEPTOR, TYPE 1, MEMBER 3; FRAGMENT: UNP RESIDUES 12 - 483; SYNONYM: T1R3; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQTNEDPRT 5 GYSMN 17 LINPYNGDTTYKQKFKG 15 SGRGAPTTTTAWFTY crystal 2.20A 19.70% FAB 02-FEB-17 20170202 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MEDAKA FISH TASTE RECEPTOR T1R2A - T1R3 LIGAND BINDING DOMAINS IN COMPLEX WITH L - ARGININE MOLECULE: TASTE RECEPTOR, TYPE 1, MEMBER 3; FRAGMENT: UNP RESIDUES 12 - 483; SYNONYM: T1R3; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQTNEDPRT 5 GYSMN 17 LINPYNGDTTYKQKFKG 15 SGRGAPTTTTAWFTY crystal 2.60A 18.90% FAB 02-FEB-17 20170202 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MEDAKA FISH TASTE RECEPTOR T1R2A - T1R3 LIGAND BINDING DOMAINS IN COMPLEX WITH L - GLUTAMATE MOLECULE: TASTE RECEPTOR, TYPE 1, MEMBER 3; FRAGMENT: UNP RESIDUES 12 - 483; SYNONYM: T1R3; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQTNEDPRT 5 GYSMN 17 LINPYNGDTTYKQKFKG 15 SGRGAPTTTTAWFTY crystal 2.61A 15.70% FAB 02-FEB-17 20170202 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE MEDAKA FISH TASTE RECEPTOR T1R2A - T1R3 LIGAND BINDING DOMAINS IN COMPLEX WITH GLYCINE MOLECULE: TASTE RECEPTOR, TYPE 1, MEMBER 3; FRAGMENT: UNP RESIDUES 12 - 483; SYNONYM: T1R3; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQTNEDPRT 5 GYSMN 17 LINPYNGDTTYKQKFKG 15 SGRGAPTTTTAWFTY crystal 2.60A 15.70% FAB 02-FEB-17 20170202 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI - CD147 MONOCLONAL ANTIBODY 6H8 ? ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 9 GQSYSYPFT 5 NFWMN 19 EIRLKSNNYATHYAESVKG 5 YDYEY crystal 1.45A 20.70% FAB 13-FEB-17 20170213 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI - OSTEOCALCIN C - TERMINAL PEPTIDE ANTIBODY KTM219 ? ? ? MUS MUSCULUS 16 CTSSQSLLHSNGDTYL 7 YTLSNRF 10 CSQTTHVPYT 5 NYWIH 17 EIDPSDGYSNYNQKFKG 7 STSVGGS crystal 1.90A 18.30% FAB 18-FEB-17 20170218 IMMUNE SYSTEM PD - L1 IN COMPLEX WITH ATEZOLIZUMAB MOLECULE: PROGRAMMED CELL DEATH 1 LIGAND 1; FRAGMENT: UNP RESIDUES 18 - 134; SYNONYM: PROGRAMMED DEATH LIGAND 1,B7 HOMOLOG 1,B7 - H1; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 17 KFPVEKELDLAALIVYW 7 DLKVQHS 15 YRCMISYGGADYKRI 5 DSWIH 17 WISPYGGSTYYADSVKG 9 RHWPGGFDY crystal 3.10A 21.00% ? 03-MAR-17 20170303 IMMUNE SYSTEM PD - L1 IN COMPLEX WITH DURVALUMAB MOLECULE: PROGRAMMED CELL DEATH 1 LIGAND 1; FRAGMENT: UNP RESIDUES 18 - 134; SYNONYM: PROGRAMMED DEATH LIGAND 1,B7 HOMOLOG 1,B7 - H1; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RASQRVSSSYLA 7 DASSRAT 9 QQYGSLPWT 5 RYWMS 17 NIKQDGSEKYYVDSVKG 12 EGGWFGELAFDY crystal 2.66A 18.30% ? 03-MAR-17 20170303 IMMUNE SYSTEM STRUCTURAL MIMICRY OF THE DENGUE VIRUS ENVELOPE GLYCOPROTEIN REVEALED BY THE CRYSTALLOGRAPHIC STUDY OF AN IDIOTYPE - ANTI - IDIOTYPE FAB COMPLEX. . ? ? HOMO SAPIENS 11 RASQNVYSYLG 7 GVTSRAT 9 QQYAGSAYT 5 SYAIS 17 GIIPIFGTANYAQKFQG 6 GLPVDY crystal 2.50A 18.70% FAB 13-MAR-17 20170313 IMMUNE SYSTEM / PROTEIN BINDING STRUCTURE OF SCARB2 - JL2 COMPLEX MOLECULE: LYSOSOME MEMBRANE PROTEIN 2; FRAGMENT: UNP RESIDUES 37 - 430; SYNONYM: 85 KDA LYSOSOMAL MEMBRANE SIALOGLYCOPROTEIN,LGP85,CD36 ANTIGEN - LIKE 2,LYSOSOME MEMBRANE PROTEIN II,LIMP II,SCAVENGER RECEPTOR CLASS B MEMBER 2; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSISDYLH 6 KYQSIS 9 QNGHSFPFT 5 GYNMN 17 NIDPYYGDTRYNQKFKD 13 SRGSTSYFYGMDY crystal 3.50A 24.10% ? 20-MAR-17 20170320 IMMUNE SYSTEM CRYSTAL STRUCTURE OF P20.1 FV - CLASP FRAGMENT WITH ITS ANTIGEN PEPTIDE MOLECULE: C8 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 14 RSSTGAVTTSNYAN 7 GTNNRVP 9 ALWYSNHWV 5 TAGMQ 17 WINTRSGVPKYAEDFKG 7 EGPGFVY crystal 1.31A 16.60% FV 23-MAR-17 20170323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF P20.1 FV - CLASP FRAGMENT WITH ITS ANTIGEN PEPTIDE MOLECULE: C8 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 14 RSSTGAVTTSNYAN 7 GTNNRVP 9 ALWYSNHWV 5 TAGMQ 17 WINTRSGVPKYAEDFKG 7 EGPGFVY crystal 1.75A 17.20% FV 23-MAR-17 20170323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 12CA5 FV - CLASP FRAGMENT WITH ITS ANTIGEN PEPTIDE MOLECULE: HA PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDNSHPLT 5 SYGMS 17 TISRGGSYTYYPDSVKG 11 RETYDEKGFAY crystal 2.20A 21.00% FV 23-MAR-17 20170323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF P20.1 FV - CLASP FRAGMENT WITH ITS ANTIGEN PEPTIDE MOLECULE: C8 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 14 RSSTGAVTTSNYAN 7 GTNNRVP 9 ALWYSNHWV 5 TAGMQ 17 WINTRSGVPKYAEDFKG 7 EGPGFVY crystal 1.17A 15.40% FV 23-MAR-17 20170323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 12CA5 FV - CLASP FRAGMENT WITH ITS ANTIGEN PEPTIDE MOLECULE: HA PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDNSHPLT 5 SYGMS 17 TISRGGSYTYYPDSVKG 11 RETYDEKGFAY crystal 2.45A 20.10% FV 23-MAR-17 20170323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NZ - 1 FV - CLASP FRAGMENT WITH ITS ANTIGEN PEPTIDE MOLECULE: PA14 PEPTIDE; ENGINEERED: YES ? ? RATTUS, HOMO SAPIENS 13 KRSTGNIGSNYVN 7 RDDKRPD 10 FCHSYSSGIV 5 NYGMA 17 SISAGGDKTYYGDSVKG 8 TSRVYFDY crystal 2.14A 23.10% FV 23-MAR-17 20170323 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TS2 / 16 FV - CLASP FRAGMENT MOLECULE: VH (S112C) - SARAH CHIMERA; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 12 SVSSIISSNYLH 7 RTSNLAS 9 QQGSDIPLT 5 SYTMS 17 TISSGGSYTYYPDSVKG 11 IGYDEDYAMDH crystal 2.04A 19.60% FV 23-MAR-17 20170323 SIGNALING PROTEIN STRUCTURE OF THE FULL - LENGTH GLUCAGON CLASS B G PROTEIN - COUPLED RECEPTOR MOLECULE: GLUCAGON RECEPTOR,ENDOLYSIN,GLUCAGON RECEPTOR; FRAGMENT: UNP RESIDUES 27 - 256,UNP RESIDUES 2 - 161,UNP RESIDUES 260 - 432; SYNONYM: GL - R,LYSIS PROTEIN,LYSOZYME,MURAMIDASE,GL - R; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQGIRNDLG 7 AASSLES 9 LQHNSNPLT 5 SYGMH 17 VMYYDGSNKDYVDSVKG 19 EKDHYDILTGYNYYYGLDV crystal 3.00A 21.10% ? 06-APR-17 20170406 SIGNALING PROTEIN STRUCTURE OF THE FULL - LENGTH GLUCAGON CLASS B G PROTEIN - COUPLED RECEPTOR MOLECULE: GLUCAGON RECEPTOR,ENDOLYSIN,GLUCAGON RECEPTOR; FRAGMENT: UNP RESIDUES 27 - 256,UNP RESIDUES 2 - 161,UNP RESIDUES 260 - 432; SYNONYM: GL - R,LYSIS PROTEIN,LYSOZYME,MURAMIDASE,GL - R; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: THE FUSION PROTEIN OF GLUCAGON RECEPTOR (UNP RESIDUES 27 - 256) , ENDOLYSIN (UNP RESIDUES 2 - 161) AND GLUCAGON RECEPTOR (UNP RESIDUES 260 - 432); ? ? HOMO SAPIENS 11 RASQGIRNDLG 7 AASSLES 9 LQHNSNPLT 5 SYGMH 17 VMYYDGSNKDYVDSVKG 19 EKDHYDILTGYNYYYGLDV crystal 3.19A 20.70% ? 06-APR-17 20170406 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TRASTUZUMAB FAB FRAGMENT BEARING P - AZIDO - L - PHENYLALANINE MOLECULE: POLYPEPTIDE (L CHAIN); ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 3.21A 22.70% FAB 20-APR-17 20170420 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TRASTUZUMAB FAB FRAGMENT BEARING NE - (O - AZIDOBENZYLOXYCARBONYL) - L - LYSINE MOLECULE: POLYPEPTIDE (L); ENGINEERED: YES; ? ? ESCHERICHIA COLI STR. K-12 SUBSTR. W3110 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.76A 17.40% FAB 20-APR-17 20170420 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB S40 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ, HA1 SUBUNIT. MOLECULE: HEMAGGLUTININ; FRAGMENT: HA1 SUBUNIT (UNP RESIDUES 18 - 341); ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVGFYVA 7 WSSYLYS 9 QQYYNYPLT 5 DFGIH 17 GIWPFGGYTYYADSVKG 11 FVNWDGDYMDY crystal 3.35A 23.20% FAB 24-APR-17 20170424 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FUCOSYLATED IGG1 FC COMPLEXED WITH BIS - GLYCOSYLATED SOLUBLE FORM OF FC GAMMA RECEPTOR IIIA ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: MS704; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX2160; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A, CD16A, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX93 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 23.50% FC 01-MAY-17 20170501 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FUCOSYLATED IGG FC Y296W MUTANT COMPLEXED WITH BIS - GLYCOSYLATED SOLUBLE FORM OF FC GAMMA RECEPTOR IIIA ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: MS704; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX2160; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A, CD16A, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PKANTEX93 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 22.30% FC 01-MAY-17 20170501 SIGNALING PROTEIN COMPLEX STRUCTURE OF ANGIOTENSIN II TYPE 2 RECEPTOR WITH FAB MOLECULE: SAR1, ILE8 - ANGIOTENSIN II; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVTYMY 7 DTSNLAS 9 QQWSSYPLT 5 GFGMH 17 YISSGSSLIYYADTVKG 11 SLYYGTPWFAY crystal 3.20A 23.00% FAB 02-MAY-17 20170502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HEMAGGLUTININ GLOBULAR HEAD FROM AN H7N9 INFLUENZA VIRUS IN COMPLEX WITH A NEUTRALIZING ANTIBODY HNIGGA6 MOLECULE: INFLUENZA A VIRUS; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPPA 7 SGGYYWS 16 YIYYSGSTDYNPSLKS 15 GSTGDRHYYYYGMDV crystal 1.78A 20.80% ? 09-MAY-17 20170509 IMMUNE SYSTEM STRUCTURE OF ANTI - ANGIOTENSIN II TYPE2 RECEPTOR ANTIBODY (D5711 - 4A03) ? ? ? MUS MUSCULUS 10 SASSSVTYMY 7 DTSNLAS 9 QQWSSYPLT 5 GFGMH 17 YISSGSSLIYYADTVKG 11 SLYYGTPWFAY crystal 1.70A 18.10% FAB 10-MAY-17 20170510 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN IGM RHEUMATOID FACTOR YES8C IN COMPLEX WITH IGG1 FC ? ? IGM MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_PLASMID: PET22B; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_PLASMID: PET22B 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 22.30% FC 15-MAY-17 20170515 IMMUNE SYSTEM STRUCTURE OF MONOMERIC MUTANT OF REI IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN CRYSTALLIZED AT PH 6 ? KAPPA ? HOMO SAPIENS 11 CQASQDIIKYL 7 YEASNLQ 10 CQQYQSLPKT 0 N/A 0 N/A 0 N/A crystal 2.88A 25.90% LC-dimer 31-MAY-17 20170531 IMMUNE SYSTEM CATALYTIC ANTIBODY 7B9 ? ? ? MUS MUSCULUS 11 HASQGIRSNIG 7 LGTNLED 9 VQYAQFPRT 5 DYNMN 17 NIDPYYGSTKYNQKFED 9 SNKYTGSVY crystal 2.20A 19.50% FAB 07-JUN-17 20170607 IMMUNE SYSTEM STRUCTURE OF MONOMERIC MUTANT OF REI IMMUNOGLOBULIN LIGHT CHAIN VARIABLE DOMAIN CRYSTALLIZED AT PH 8 Y96K MUTANT OF REI VL KAPPA ? HOMO SAPIENS 11 CQASQDIIKYL 7 YEASNLQ 10 CQQYQSLPKT 0 N/A 0 N/A 0 N/A crystal 2.90A 23.40% LC-dimer 07-JUN-17 20170607 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN MONOCLONAL ANTIBODY H3V - 47 ? ? ? HOMO SAPIENS 12 RTSQGVSSSYLA 7 GSSSRAT 8 QQYATSPT 5 SYSIT 17 GIFPIFGSTNYAQKFDD 18 GASKVEPAAPAYSDAFDM crystal 2.60A 18.30% FAB 09-JUN-17 20170609 VIRUS STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS A - PARTICLE IN COMPLEX WITH THE NEUTRALIZING ANTIBODY FRAGMENT 1D5 MOLECULE: GENOME POLYPROTEIN; FRAGMENT: UNP RESIDUES 70 - 325; ? ? MUS MUSCULUS 11 KASQDVNTAVA 7 SASYRYT 9 QQHYTTPHT 5 TYDMS 17 HISSGGGYIYYPDTVKG 10 QKGLYYGFDY ElectronMicroscopy N/A N/A FAB 12-JUN-17 20170612 SIGNALING PROTEIN CRYSTAL STRUCTURE OF THE COMPLEX OF 059 - 152 - FV AND EGFR - ECD MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; FRAGMENT: UNP RESIDUES 1 - 643; SYNONYM: PROTO - ONCOGENE C - ERBB - 1,RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 YDSDRPS 11 QVWDSSSDHVV 7 SSSYYWG 16 SIYYSGSTYYNPSLKS 10 LPMVTMSFDY crystal 2.89A 28.00% FV 29-JUN-17 20170629 IMMUNE SYSTEM COMPLEX STRUCTURE OF PD - L1 WITH ATEZOLIZUMAB FAB MOLECULE: PROGRAMMED CELL DEATH 1 LIGAND 1; FRAGMENT: IGV DOMAIN,UNP RESIDUES 18 - 133; SYNONYM: PROGRAMMED DEATH LIGAND 1,B7 HOMOLOG 1,B7 - H1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQDVSTAVA 7 SASFLYS 9 QQYLYHPAT 5 DSWIH 17 WISPYGGSTYYADSVKG 9 RHWPGGFDY crystal 2.90A 23.90% FAB 05-JUL-17 20170705 VIRUS / IMMUNE SYSTEM CRYO - EM STRUCTURE OF ZIKA VIRUS COMPLEXED WITH FAB OF ZKA190 AT PH 8.0 AND 37 CELSIUS DEGREE MOLECULE: PROTEIN E; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 DASSRAT 9 QQYGRSRWT 5 KYGMH 17 VISYEGSNKYYADSVKG 21 SGTQYYDTTGYEYRGLEYFGY ElectronMicroscopy N/A N/A FAB 15-JUL-17 20170715 IMMUNE SYSTEM / VIRAL SYSTEM SFTSV GN WITH NEUTRALIZING ANTIBODY MAB4 - 5 MOLECULE: MEMBRANE GLYCOPROTEIN POLYPROTEIN; FRAGMENT: UNP RESIDUES 20 - 340; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSNLA 7 GASTRAT 10 QQYNNWPPYT 6 TNYWIG 17 GIIFPGDSDTRYSPSFQ 15 RLKRRGFSGEGYFDY crystal 2.10A 17.10% ? 19-JUL-17 20170719 IMMUNE SYSTEM A HUMAN ANTIBODY AF4H1L1 ? ? ? HOMO SAPIENS 11 SGDKLGDKYAC 7 QDSKRPS 9 QAWDSSTVV 5 AYAMH 17 VITFDGGYQYYADSVKG 12 DPLTVSGGYFDY crystal 2.10A 22.00% FAB 26-JUL-17 20170726 ANTIMICROBIAL PROTEIN CRYSTAL STRUCTURE OF A GROUP 2 HA BINDING ANTIBODY AF4H1K1 FAB IN COMPLEX WITH THE 1968 H3N2 PANDEMIC (H3 - AC / 68) HEMAGGLUTININ MOLECULE: HEMAGGLUTININ; FRAGMENT: UNP RESIDUES 346 - 521; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 RASSRAT 8 QQYGSSFT 5 AYAMH 17 VITFDGGYQYYADSVKG 19 DPLTKLLPFDWVSGGYFDY crystal 2.90A 21.40% FAB 26-JUL-17 20170726 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A GROUP 2 HA BINDING ANTIBODY AF4H1K1 FAB IN COMPLEX WITH THE H4N6 DUCK ISOLATE (H4 - CZ / 56) HEMAGGLUTININ MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 RASSRAT 8 QQYGSSFT 5 AYAMH 17 VITFDGGYQYYADSVKG 19 DPLTKLLPFDWVSGGYFDY crystal 3.80A 23.80% FAB 26-JUL-17 20170726 IMMUNE SYSTEM FC MUTANT (K392D / K409D / D399K) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: MAMMALIAN EXPRESSION VECTOR PCBIO; EXPRESSION_SYSTEM_TAXID: 386595; EXPRESSION_SYSTEM_CELL_LINE: HEK 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.65A 26.40% FC 07-AUG-17 20170807 TRANSFERASE / IMMUNE SYSTEM COMPLEX STRUCTURE OF CYCLIN G - ASSOCIATED KINASE WITH GEFITINIB MOLECULE: CYCLIN - G - ASSOCIATED KINASE; FRAGMENT: UNP RESIDUES 25 - 335; EC: 2.7.11.1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 DSYMS 17 GIWEDSSAAHYRDSVKG 14 RGYSGDYRPINNPS crystal 2.80A 23.60% HC-dimer 18-AUG-17 20170818 TRANSFERASE / IMMUNE SYSTEM COMPLEX STRUCTURE OF CYCLIN G - ASSOCIATED KINASE WITH GEFITINIB MOLECULE: CYCLIN - G - ASSOCIATED KINASE; FRAGMENT: UNP RESIDUES 25 - 335; EC: 2.7.11.1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NDSYM 17 AGIWEDSSAAHYRDSVK 15 RRGYSGDYRPINNPS crystal 2.50A 23.20% HC-dimer 18-AUG-17 20170818 STRUCTURAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HPV58 PENTAMER IN COMPLEX WITH THE FAB FRAGMENT OF ANTIBODY A12A3 MOLECULE: MAJOR CAPSID PROTEIN L1; FRAGMENT: UNP RESIDUES 36 - 524; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDINKYIA 7 YTFTLQP 8 LQYHNLYT 5 DYYMH 17 WIDPENGKTIYDPRFRG 11 SNYRYDRSFDY crystal 3.44A 20.50% FAB 24-AUG-17 20170824 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HPV59 PENTAMER IN COMPLEX WITH THE FAB FRAGMENT OF ANTIBODY 28F10 MOLECULE: MAJOR CAPSID PROTEIN L1; FRAGMENT: UNP RESIDUES 10 - 508; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPFT 5 DYTMS 17 SISSGGTYTYYPDTVKG 14 ASPYYDYDEGYMDY crystal 3.35A 23.20% FAB 24-AUG-17 20170824 PROTEIN BINDING BAFF IN COMPLEX WITH BELIMUMAB MOLECULE: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B; SYNONYM: B LYMPHOCYTE STIMULATOR,BLYS,B - CELL - ACTIVATING FACTOR,BAFF, DENDRITIC CELL - DERIVED TNF - LIKE MOLECULE,TNF - AND APOL - RELATED LEUKOCYTE EXPRESSED LIGAND 1,TALL - 1; ENGINEERED: YES ? ? HOMO SAPIENS 11 QGDSLRSYYAS 7 GKNNRPS 11 SSRDSSGNHWV 5 NNAIN 17 GIIPMFGTAKYSQNFQG 14 SRDLLLFPHHALSP crystal 2.05A 18.20% ? 25-AUG-17 20170825 PROTEIN BINDING STRUCTURE OF THE BELIMUMAB FAB FRAGMENT MOLECULE: BELIMUMAB LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QGDSLRSYYAS 7 GKNNRPS 11 SSRDSSGNHWV 5 NNAIN 17 GIIPMFGTAKYSQNFQG 14 SRDLLLFPHHALSP crystal 1.90A 16.90% FAB 25-AUG-17 20170825 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HUMAN NEUTRALIZING ANTIBODY BOUND TO A HBV PRES1 PEPTIDE MOLECULE: LARGE ENVELOPE PROTEIN; FRAGMENT: PRES1 PEPTIDE, UNP RESIDUES 2 - 59; ENGINEERED: YES ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.50A 24.50% scFv 02-SEP-17 20170902 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IGG - FC IN COMPLEX WITH AGLYCAN AND OPTIMIZED FC GAMMA RECEPTOR IIIA ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: UNIDENTIFIED; EXPRESSION_SYSTEM_TAXID: 32644; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3A, CD16A, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.71A 21.20% FC 06-SEP-17 20170906 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SCFV ANTIBODY 4B08 WITH EPITOPE PEPTIDE MOLECULE: EPITOPE PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.35A 13.60% scFv 11-SEP-17 20170911 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SCFV ANTIBODY 4B08 WITH EPITOPE PEPTIDE (MUTATION T6A) MOLECULE: EPITOPE PEPTIDE (MUTATION T6A); ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.35A 13.60% scFv 11-SEP-17 20170911 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SCFV ANTIBODY 4B08 WITH EPITOPE PEPTIDE (MUTATION N3A) MOLECULE: PEPTIDE EPITOPE (MUTATION N3A); ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.96A 20.50% scFv 11-SEP-17 20170911 NUCLEAR PROTEIN CRYSTAL STRUCTURE OF THE COMPLEX OF DI - ACETYLATED HISTONE H4 AND 2A7D9 FAB FRAGMENT MOLECULE: DI - ACETYLATED HISTONE H4; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDINKYIA 7 YTSTLQP 8 LQYDNLRT 5 DYSMH 17 WINTATGEPTYADDFKG 2 DY crystal 1.70A 16.80% FAB 15-SEP-17 20170915 NUCLEAR PROTEIN CRYSTAL STRUCTURE OF THE COMPLEX OF DI - ACETYLATED HISTONE H4 AND 1A9D7 FAB FRAGMENT MOLECULE: DI - ACETYLATED HISTONE H4; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQDINNYIA 7 YTSTLQP 8 LQYDNLRT 5 DYSMH 17 WINTETGEPTYADDFKG 2 DY crystal 1.80A 19.40% FAB 15-SEP-17 20170915 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CLINICALLY IMPORTANT GPCR IN COMPLEX WITH FUNCTIONAL ANTIBODY WITH FUNCTIONAL ANTIBODY ? ? MUS MUSCULUS 11 KASQDINRYLS 7 RANRMLD 9 LQYDEFPFT 5 TYNIY 17 YIDPYNGGTSYNQKFRG 10 RWYTGDWFAY crystal 1.85A 19.60% FAB 21-SEP-17 20170921 SIGNALING PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CLINICALLY IMPORTANT GPCR IN COMPLEX WITH FUNCTIONAL ANTIBODY. MOLECULE: PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE; FRAGMENT: UNP RESIDUES 4 - 217, 260 - 366; SYNONYM: PGE2 RECEPTOR EP4 SUBTYPE,PROSTANOID EP4 RECEPTOR; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 17 VLCKSRKEQKETTFYTL 7 SPVTIAT 15 AMSVERYLAINHAYF 5 TYNIY 17 YIDPYNGGTSYNQKFRG 12 RWYTYDGDWFAY crystal 4.20A 33.40% FAB 28-SEP-17 20170928 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HUMAN TUMOR NECROSIS FACTOR IN COMPLEX WITH GOLIMUMAB FV MOLECULE: TUMOR NECROSIS FACTOR; SYNONYM: CACHECTIN,TNF - ALPHA,TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 2,TNF - A; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVYSYLA 7 DASNRAT 10 QQRSNWPPFT 5 SYAMH 17 FMSYDGSNKKYADSVKG 17 DRGIAAGGNYYYYGMDV crystal 2.73A 19.20% FV 31-OCT-17 20171031 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY 1H1 FAB MOLECULE: 1H1 HEAVY CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 12 TASSSVSSSYLH 7 STYNLAG 9 QQYHRSPWT 5 SYWIH 17 EINTSSGRTNYNERFKN 10 EGFGNQSLDY crystal 2.50A 21.60% FAB 14-NOV-17 20171114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF FVIIA ANTIBODY MAB4F5 ? ? ? MUS MUSCULUS 12 KASQDVGIGLVS 7 WASTRHT 9 QQFSNYPLT 5 DYGMA 16 FISNLSRIYYADTVTG 9 DDGYYRVDY crystal 1.81A 20.90% FV 22-NOV-17 20171122 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 2H4 FAB MOLECULE: 2H4 LIGHT CHAIN; ? ? MUS MUSCULUS 12 RASQSVSTSYMH 7 LVSNLES 15 QHIRELTRSEAGPSW 5 DYSMH 17 WINTGTGEPTFAADFKG 9 GVGLYGVDY crystal 2.21A 21.80% FAB 29-NOV-17 20171129 VIRUS STRUCTURE OF JEV - 2F2 FAB COMPLEX MOLECULE: JEV M PROTEIN; ? ? JAPANESE ENCEPHALITIS VIRUS 12 RASQSVSTSYMH 7 LVSNLES 15 QHIRELTRSEAGPSW 5 DYAMH 17 WINTATGEPTYAYDFKE 9 DGRYWYFGV ElectronMicroscopy N/A N/A FAB 29-NOV-17 20171129 IMMUNE SYSTEM JEV - 2H4 FAB COMPLEX MOLECULE: JEV M PROTEIN; ? ? MUS MUSCULUS 12 RASQSVSTSYMH 7 LVSNLES 15 QHIRELTRSEAGPSW 5 DYSMH 17 WINTGTGEPTFAADFKG 9 GVGLYGVDY ElectronMicroscopy N/A N/A FAB 29-NOV-17 20171129 SIGNALING PROTEIN - IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CLINICALLY IMPORTANT GPCR IN COMPLEX WITH FUNCTIONAL ANTIBODY. MOLECULE: PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE,PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE; SYNONYM: PGE2 RECEPTOR EP4 SUBTYPE,PROSTANOID EP4 RECEPTOR; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 17 VLCKSRKEQKETTFYTL 7 SPVTIAT 15 AMSVERYLAINHAYF 5 TYNIY 17 YIDPYNGGTSYNQKFRG 12 RWYTYDGDWFAY crystal 3.20A 22.40% FAB 30-NOV-17 20171130 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SCFV ANTIBODY 4B08 WITH SULFATED EPITOPE PEPTIDE MOLECULE: C - C CHEMOKINE RECEPTOR TYPE 5; SYNONYM: CCR5,CHEMR13,HIV - 1 FUSION CORECEPTOR; ENGINEERED: YES ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.59A 15.80% scFv 07-DEC-17 20171207 VIRAL PROTEIN STRUCTURAL DEFINITION OF A UNIQUE NEUTRALIZATION EPITOPE ON THE RECEPTOR - BINDING DOMAIN OF MERS - COV SPIKE GLYCOPROTEIN MOLECULE: MERS - COV RBD; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGNNYVY 7 WNDQRPS 11 AAWDDSLSGAV 5 NYAMY 17 LISYDISTDYYADSVKG 3 TYY crystal 2.80A 24.80% ? 08-DEC-17 20171208 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - TAU ANTIBODY CBTAU - 24.1 IN COMPLEX WITH ITS PHOSPHORYLATED TAU PEPTIDE MOLECULE: PHOSPHORYLATED TAU PEPTIDE; ENGINEERED: YES KAPPA ? HOMO SAPIENS 17 KSSESLLYDSNNKNYLA 7 WASTRES 9 QQYFSTPWT 5 GYYLH 17 WVNPRSGGTSYPPKFQG 11 GRIPDVTAFDI crystal 2.60A 20.20% ? 14-MAR-18 20180314 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB REGION OF A NEUTRALIZING FULLY HUMAN ANTIBODY AGAINST GM - CSF P01857 (UNIPROT) IS REFERRED.; ? IGG HOMO SAPIENS 13 SGSSSNIGNSYVY 7 RNNRRPS 11 ATWDDSLSGRL 5 RYGIK 17 WINTRSGVPAYAQGFTG 18 RPPRFYDKTEYWEDGFDV crystal 1.81A 16.30% FAB 04-APR-18 20180404 VIRAL PROTEIN STRUCTURE OF GLYCOPROTEIN B DOMAIN IV OF PSEUDORABIES VIRUS WITH 7B11 ANTIBODY MOLECULE: ENVELOPE GLYCOPROTEIN B,ENVELOPE GLYCOPROTEIN B; SYNONYM: GB,GB; ENGINEERED: YES ? ? MUS MUSCULUS 11 KARQDVGSAVN 7 RASTRHT 9 QQYGNYDLT 5 DYAMS 17 TISGGGSYSYYPDSVKG 10 QEGDFPLFDY crystal 3.29A 24.40% ? 26-APR-18 20180426 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - TAU ANTIBODY CBTAU - 28.1 IN COMPLEX WITH ITS TAU PEPTIDE MOLECULE: PEPTIDE FROM MICROTUBULE - ASSOCIATED PROTEIN TAU; SYNONYM: TAU PEPTIDE; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 17 ESSQTLLYSSNEKNYLA 7 WASTPES 9 QQYYNSPYT 5 NYWIG 17 IIYPGDSDTRYSPPFQG 12 VGRPSKGGWFDP crystal 2.09A 19.10% ? 09-MAY-18 20180509 VIRAL PROTEIN STRUCTURAL DEFINITION OF A UNIQUE NEUTRALIZATION EPITOPE ON THE RECEPTOR - BINDING DOMAIN OF MERS - COV SPIKE GLYCOPROTEIN MOLECULE: MERS - COV RBD; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGNNYVY 7 WNDQRPS 11 AAWDDSLSGAV 5 NYAMY 17 LISYDISTDYYADSVKG 3 NDY crystal 4.48A 31.00% ? 21-MAY-18 20180521 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY 13D4 ? ? ? MUS MUSCULUS 11 KASQNVGTHLA 7 SASYRYS 9 QQYNNFPLT 5 GHWIE 17 EILPGSGNIHYNEKFKG 14 LGTTAVERDWYFDV crystal 2.30A 20.70% FAB 06-JUN-18 20180606 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY 13D4 BOUND TO H5N1 INFLUENZA HEMAGGLUTININ, HA HEAD REGION MOLECULE: HEMAGGLUTININ,ENVELOPE GLYCOPROTEIN; ENGINEERED: YES; OTHER_DETAILS: THE FUSION PROTEIN OF HEMAGGLUTININ (UNP RESIDUES 17 - 520, LINKER, ENVELOPE GLYCOPROTEIN (UNP RESIDUES 1 - 28) , AND HIS TAGS.; ? ? MUS MUSCULUS 11 KASQNVGTHLA 7 SASYRYS 9 QQYNNFPLT 5 GHWIE 17 EILPGSGNIHYNEKFKG 14 LGTTAVERDWYFDV crystal 2.33A 17.40% FAB 06-JUN-18 20180606 IMMUNE SYSTEM COMPLEX STRUCTURE OF 4 - 1BB AND UTOMILUMAB MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9; SYNONYM: 4 - 1BB LIGAND RECEPTOR,CDW137,T - CELL ANTIGEN 4 - 1BB HOMOLOG,T - CELL ANTIGEN ILA; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDNIGDQYAH 7 QDKNRPS 11 ATYTGFGSLAV 5 TYWIS 17 KIYPGDSYTNYSPSFQG 7 GYGIFDY crystal 2.00A 18.60% ? 17-JUN-18 20180617 VIRAL PROTEIN / IMMUNE SYSTEM HUMAN ANTIBODY 32D6 FAB IN COMPLEX WITH H1N1 INFLUENZA A VIRUS HA1 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 12 TLSSGHSTYAIA 7 LSSGGRH 12 DYYCQTWDAGMV 7 TGSYYWS 16 YSSVSGTSNYNPSLKS 14 LNYDILTGYYFFDF crystal 3.15A 17.80% FAB 20-JUN-18 20180620 IMMUNE SYSTEM CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY FLD21.140 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? HOMO SAPIENS 13 SGSTSNIGSNAVN 7 SNNQRPS 12 AAWDDSLSGSWV 7 SGTYYWS 16 YIYHSGSAYYNPSLES 15 AENLLSPYLAEGFDP crystal 2.33A 19.90% FAB 26-JUN-18 20180626 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF B5209B, A MURINE MONOCLONAL ANTIBODY SPECIFIC FOR THE FIFTH IMMUNOGLOBULIN DOMAIN (IG5) OF HUMAN ROBO1 ? ? ? MUS MUSCULUS 11 GASENIYGALT 7 GAINLAD 9 QNVLSTPFT 5 TYDMS 17 TINSNGGSTYYPDSVKG 13 EALLRPPYYALDY crystal 1.50A 13.10% FAB 02-JUL-18 20180702 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FIFTH IMMUNOGLOBULIN DOMAIN (IG5) OF HUMAN ROBO1 IN COMPLEX WITH THE FAB FRAGMENT OF MURINE MONOCLONAL ANTIBODY B5209B MOLECULE: ROUNDABOUT HOMOLOG 1; SYNONYM: DELETED IN U TWENTY TWENTY,H - ROBO - 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 GASENIYGALT 7 GAINLAD 9 QNVLSTPFT 5 TYDMS 17 TINSNGGSTYYPDSVKG 13 EALLRPPYYALDY crystal 2.00A 24.00% FAB 02-JUL-18 20180702 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FIFTH IMMUNOGLOBULIN DOMAIN (IG5) OF HUMAN ROBO1 IN COMPLEX WITH THE SCFV FRAGMENT OF MURINE MONOCLONAL ANTIBODY B5209B MOLECULE: ROUNDABOUT HOMOLOG 1; SYNONYM: DELETED IN U TWENTY TWENTY,H - ROBO - 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 TCGASENIYGA 7 IYGAINL 11 YCQNVLSTPFT 5 TYDMS 17 TINSNGGSTYYPDSVKG 13 EALLRPPYYALDY crystal 2.10A 24.10% FV 02-JUL-18 20180702 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FIFTH IMMUNOGLOBULIN DOMAIN (IG5) OF HUMAN ROBO1 IN COMPLEX WITH THE MUTANT SCFV FRAGMENT (P103A) OF MURINE MONOCLONAL ANTIBODY B5209B MOLECULE: ROUNDABOUT HOMOLOG 1; SYNONYM: DELETED IN U TWENTY TWENTY,H - ROBO - 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 TCGASENIYGA 7 IYGAINL 11 YCQNVLSTPFT 5 TYDMS 17 TINSNGGSTYYPDSVKG 13 EALLRPAYYALDY crystal 2.31A 27.40% FV 02-JUL-18 20180702 VIRUS THE STRUCTURE OF CVA10 VIRUS A - PARTICLE FROM ITS COMPLEX WITH FAB 2G8 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: COXSACKIEVIRUS A10; ORGANISM_TAXID: 42769; MOL_ID: 2; ORGANISM_SCIENTIFIC: COXSACKIEVIRUS A10; ORGANISM_TAXID: 42769; MOL_ID: 3; ORGANISM_SCIENTIFIC: COXSACKIEVIRUS A10; ORGANISM_TAXID: 42769 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 28-JUL-18 20180728 VIRUS / IMMUNE SYSTEM THE STRUCTURE OF CVA10 MATURE VIRION IN COMPLEX WITH FAB 2G8 MOLECULE: VP2; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 TVSNRFS 9 FQGSHIPYT 5 SYYIH 17 YINCYNGDITYNQKFKG 12 ERYGTPHYHFDV ElectronMicroscopy N/A N/A FAB 28-JUL-18 20180728 VIRUS THE STRUCTURE OF CVA10 PROCAPSID FROM ITS COMPLEX WITH FAB 2G8 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: COXSACKIEVIRUS A10; ORGANISM_TAXID: 42769; MOL_ID: 2; ORGANISM_SCIENTIFIC: COXSACKIEVIRUS A10; ORGANISM_TAXID: 42769; MOL_ID: 3; ORGANISM_SCIENTIFIC: COXSACKIEVIRUS A10; ORGANISM_TAXID: 42769 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 28-JUL-18 20180728 VIRUS THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 MOLECULE: CAPSID PROTEIN VP2; SYNONYM: VIRION PROTEIN 2; ? ? MUS MUSCULUS 8 QDIRGNLD 7 STSNLNS 9 LQRNAYPLT 5 NYWMH 17 YVNPNTDYTDYNHKFKD 11 GTFGNYASFAY ElectronMicroscopy N/A N/A FAB 27-AUG-18 20180827 VIRUS THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 AND 11G1 MOLECULE: CAPSID PROTEIN VP2; SYNONYM: VIRION PROTEIN 2; ? ? MUS MUSCULUS 17 KSSQSLLYSNNQKNYLA 7 WASTRES 9 QQYYNYPWT 3 DYV 18 GVISTYYGDGSYNQKFKG 13 GENYYGVSGTMDY ElectronMicroscopy N/A N/A FAB 27-AUG-18 20180827 SIGNALING PROTEIN THE NZ - 1 FAB COMPLEXED WITH THE PDZ TANDEM FRAGMENT OF A. AEOLICUS S2P HOMOLOG WITH THE PA12 TAG INSERTED BETWEEN THE RESIDUES 263 AND 267 MOLECULE: PDZ TANDEM FRAGMENT WITH PA TAG INSERTION; FRAGMENT: UNP RESIDUES 115 - 263 AND 267 - 292; EC: 3.4.24. -; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVN 7 RDDKRPD 10 FCHSYSSGIV 5 NYGMA 17 SISAGGDKTYYGDSVKG 8 TSRVYFDY crystal 2.60A 20.10% FAB 05-SEP-18 20180905 SIGNALING PROTEIN THE NZ - 1 FAB COMPLEXED WITH THE PDZ TANDEM FRAGMENT OF A. AEOLICUS S2P HOMOLOG WITH THE PA12 TAG INSERTED BETWEEN THE RESIDUES 181 AND 184 MOLECULE: PDZ TANDEM FRAGMENT WITH PA TAG INSERTION; FRAGMENT: UNP RESIDUES 115 - 181 AND 184 - 292; EC: 3.4.24. -; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVN 7 RDDKRPD 10 FCHSYSSGIV 5 NYGMA 17 SISAGGDKTYYGDSVKG 8 TSRVYFDY crystal 3.20A 28.00% FAB 05-SEP-18 20180905 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - CD19 ANTIBODY B43 FAB MOLECULE: B43 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 15 KASQSVDYSGDSYLN 7 DASNLVS 9 QQSTENPWT 5 SYWMN 17 QIWPGDSDTNYAQKFQG 15 RETTTVGRYYYAMDY crystal 2.45A 20.60% FAB 07-AUG-17 20170807 IMMUNE SYSTEM COMPLEX BETWEEN CD19 (N138Q MUTANT) AND B43 FAB MOLECULE: B - LYMPHOCYTE ANTIGEN CD19; FRAGMENT: EXTRACELLULAR DOMAIN; SYNONYM: B - LYMPHOCYTE SURFACE ANTIGEN B4,DIFFERENTIATION ANTIGEN CD19,T - CELL SURFACE ANTIGEN LEU - 12; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 15 KASQSVDYSGDSYLN 7 DASNLVS 9 QQSTENPWT 5 SYWMN 17 QIWPGDSDTNYAQKFQG 15 RETTTVGRYYYAMDY crystal 3.00A 19.30% FAB 07-AUG-17 20170807 IMMUNE SYSTEM CAT192 FAB WILD TYPE ? ? ? HOMO SAPIENS 11 RASQGIGDDLG 7 GTSTLQS 9 LQDSNYPLT 5 SYGMH 17 VISYDGSIKYYADSVKG 2 RS crystal 2.49A 20.90% FAB 09-AUG-17 20170809 IMMUNE SYSTEM CAT192 FAB INSERTION MUTANT H0 / L1 ? ? ? HOMO SAPIENS 11 RASQGIGDDLG 7 GTSTLQS 9 LQDSNYPLT 5 SYGMH 17 VISYDGSIKYYADSVKG 5 TGEYS crystal 2.80A 25.20% FAB 10-AUG-17 20170810 IMMUNE SYSTEM LL2 FAB IN COMPLEX WITH ANTI - KAPPA VHH DOMAIN MOLECULE: ANTI KAPPA VHH DOMAIN; ENGINEERED: YES; KAPPA ? MUS MUSCULUS 17 KSSQSVLYSANHKNYLA 7 WASTRES 8 HQYLSSWT 5 SYWLH 17 YINPRNDYTEYNQNFKD 7 RDITTFY crystal 1.70A 21.50% FAB 12-AUG-17 20170812 IMMUNE SYSTEM PINATUZUMAB FAB IN COMPLEX WITH ANTI - KAPPA VHH DOMAIN MOLECULE: ANTI - KAPPA VHH DOMAIN; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 10 RSSQSIVFLE 7 KVSNRFS 9 FQGSQFPYT 5 RSWMN 17 RIYPGDGDTQYSGKFKG 11 DGSSWDWYFDV crystal 1.75A 24.30% FAB 12-AUG-17 20170812 IMMUNE SYSTEM COLTUXIMAB FAB IN COMPLEX WITH ANTI - KAPPA VHH DOMAIN MOLECULE: ANTI - KAPPA VHH DOMAIN; ENGINEERED: YES; KAPPA ? HOMO SAPIENS 10 SASSGVNYMH 7 DTSKLAS 7 HQRGSYT 5 SNWMH 17 EIDPSDSYTNYNQNFQG 11 GSNPYYYAMDY crystal 2.40A 24.70% FAB 13-AUG-17 20170813 IMMUNE SYSTEM CAT192 FAB INSERTION MUTANT H5 / L0 ? ? ? HOMO SAPIENS 11 RASQGIGDDLG 7 GTSTLQS 9 LQDSNYPLT 5 SYGMH 17 VISYDGSIKYYADSVKG 6 TGEYSS crystal 2.45A 18.60% FAB 14-AUG-17 20170814 IMMUNE SYSTEM CAT192 FAB INSERTION MUTANT H2 / L2 ? ? ? HOMO SAPIENS 11 RASQGIGDDLG 7 GTSTLQS 9 LQDSNYPLT 5 SYGMH 17 VISYDGSIKYYADSVKG 14 TGEYSGYDTDPQYS crystal 2.35A 20.80% FAB 15-AUG-17 20170815 BLOOD CLOTTING / IMMUNE SYSTEM FXIA ANTIBODY COMPLEX MOLECULE: COAGULATION FACTOR XI; FRAGMENT: UNP RESIDUES 388 - 624; SYNONYM: FXI,PLASMA THROMBOPLASTIN ANTECEDENT,PTA; EC: 3.4.21.27; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQGIRNDLG 7 AASSLQS 9 LQHDIYAST 5 GYYMH 17 WIDPDEGDTNYAQKFQG 8 LASGFRDY crystal 1.80A 18.30% FAB 15-AUG-17 20170815 IMMUNE SYSTEM CRYSTAL STRUCTURE OF NON - NEUTRALIZING INFANT ANTIBODY ADI - 14359 IN COMPLEX WITH POSTFUSION RSV F GLYCOPROTEIN MOLECULE: FUSION GLYCOPROTEIN F0,FUSION GLYCOPROTEIN F0; ENGINEERED: YES; ? IGG HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPYT 7 TSGMCVS 16 RIDWDDDKYYSTSLKT 16 ATNYDSSGYYSLYFDY crystal 3.00A 22.30% FAB 17-AUG-17 20170817 IMMUNE SYSTEM CRYSTAL STRUCTURE OF INFANT ANTIBODY ADI - 19425 MOLECULE: EPIDIDYMIS LUMINAL PROTEIN 214; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GNSNRPS 12 QSYDSSLSGFYV 5 SYSMN 17 SISSSSSYIYYADSVKG 13 LGYCSGGSCHFDY crystal 1.70A 17.60% ? 17-AUG-17 20170817 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RSV F BOUND BY AM22 AND THE INFANT ANTIBODY ADI - 19425 MOLECULE: FUSION GLYCOPROTEIN F0,ENVELOPE GLYCOPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGYDVH 7 GNSNRPS 12 QSYDSSLSGFYV 5 SYSMN 17 SISSSSSYIYYADSVKG 13 LGYCSGGSCHFDY crystal 4.10A 20.60% FAB 17-AUG-17 20170817 IMMUNE SYSTEM ANTI - MARBURGVIRUS NUCLEOPROTEIN SINGLE DOMAIN ANTIBODY A ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IRTVA 17 SSITPWNKTTYEDSVKD 9 GWGIASMRY crystal 1.17A 14.90% HC-dimer 17-AUG-17 20170817 IMMUNE SYSTEM ANTI - MARBURGVIRUS NUCLEOPROTEIN SINGLE DOMAIN ANTIBODY A COMPLEXED WITH NUCLEOPROTEIN C - TERMINAL DOMAIN MOLECULE: NUCLEOPROTEIN; FRAGMENT: C - TERMINAL DOMAIN RESIDUES 601 - 695; SYNONYM: NUCLEOCAPSID PROTEIN,PROTEIN N; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IRTVA 17 SSITPWNKTTYEDSVKD 9 GWGIASMRY crystal 1.75A 17.60% HC-dimer 17-AUG-17 20170817 IMMUNE SYSTEM ANTI - MARBURGVIRUS NUCLEOPROTEIN SINGLE DOMAIN ANTIBODY B ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INTLG 16 RISSGGITRYADSVKG 10 RNWGGGLDVY crystal 1.90A 18.80% HC-dimer 17-AUG-17 20170817 IMMUNE SYSTEM STRUCTURE OF POM6 FAB FRAGMENT COMPLEXED WITH MOUSE PRPC MOLECULE: MAJOR PRION PROTEIN; FRAGMENT: UNP RESIDUES 127 - 225; SYNONYM: PRP,PRP27 - 30,PRP33 - 35C; ENGINEERED: YES; ? ? MUS MUSCULUS 15 KASMSVSTSTYSYMD 7 KASNNET 9 QHSWQTPLT 5 GYFMH 17 RINPYNGNTNYNKIFKK 7 SQDAWDY crystal 1.83A 19.80% FAB 18-AUG-17 20170818 IMMUNE SYSTEM STRUCTURE OF A MUTANT CETUXIMAB FAB FRAGMENT MOLECULE: CETUXIMAB MUTANT LIGHT CHAIN,UNCHARACTERIZED PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGTNIH 7 YADESID 9 QQNNNWPTT 5 DYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 1.70A 17.30% FAB 23-AUG-17 20170823 TRANSFERASE / IMMUNE SYSTEM STRUCTURE OF CETUXIMAB FAB MUTANT IN COMPLEX WITH EGFR EXTRACELLULAR DOMAIN MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; SYNONYM: PROTO - ONCOGENE C - ERBB - 1, RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGTNIH 7 YADESID 9 QQNNNWPTT 5 DYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 3.20A 23.40% FAB 23-AUG-17 20170823 IMMUNE SYSTEM 39S FAB BOUND TO HER2 ECD MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; FRAGMENT: UNP RESIDUES 23 - 652; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN,MLN 19,PROTO - ONCOGENE NEU,PROTO - ONCOGENE C - ERBB - 2,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2,P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 17 KSSQSVFFRSNNKNILA 7 WASSRES 9 QQYFGSPFT 5 SYSMS 17 SISSSSSYIYYADSVKG 12 GGDAYNYYYFDY crystal 3.77A 25.30% FAB 29-AUG-17 20170829 IMMUNE SYSTEM STRUCTURE OF CETUXIMAB WITH AMINOHEPTANOIC ACID - LINKED N - BUTYLARGININE MEDITOPE VARIANT MOLECULE: MEDITOPE; ENGINEERED: YES ? IGG MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 18.80% FAB 30-AUG-17 20170830 IMMUNE SYSTEM CRYSTAL STRUCTURE OF UNBOUND ANTI - HIV ANTIBODY FAB PGV19 AT 2.5 A ? LAMBDA ? HOMO SAPIENS 13 TASSDFRGFSSVS 7 SVNRRPS 5 NAYEF 5 DFDIH 17 WVRPLGGGVSYARQFQG 11 MGAAREWDFQY crystal 2.50A 20.10% FAB 03-SEP-17 20170903 SIGNALING PROTEIN THE THERAPEUTIC ANTIBODY LM609 SELECTIVELY INHIBITS LIGAND BINDING TO HUMAN ALPHA - V BETA - 3 INTEGRIN VIA STERIC HINDRANCE MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 27 - 718; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA,GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSISNHLH 7 YASQSIS 9 QQSNSWPHT 5 SYDMS 17 KVSSGGGSTYYLDTVQG 8 HNYGSFAY ElectronMicroscopy N/A N/A FAB 04-SEP-17 20170904 SIGNALING PROTEIN HUMAN ALPHA - V BETA - 3 INTEGRIN (INTERMEDIATE CONFORMATION) IN COMPLEX WITH THE THERAPEUTIC ANTIBODY LM609 MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 27 - 718; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA,GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSISNHLH 7 YASQSIS 9 QQSNSWPHT 5 SYDMS 17 KVSSGGGSTYYLDTVQG 8 HNYGSFAY ElectronMicroscopy N/A N/A FAB 04-SEP-17 20170904 SIGNALING PROTEIN HUMAN ALPHA - V BETA - 3 INTEGRIN (OPEN CONFORMATION) IN COMPLEX WITH THE THERAPEUTIC ANTIBODY LM609 MOLECULE: INTEGRIN BETA - 3; FRAGMENT: UNP RESIDUES 27 - 718; SYNONYM: PLATELET MEMBRANE GLYCOPROTEIN IIIA,GPIIIA; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSISNHLH 7 YASQSIS 9 QQSNSWPHT 5 SYDMS 17 KVSSGGGSTYYLDTVQG 8 HNYGSFAY ElectronMicroscopy N/A N/A FAB 04-SEP-17 20170904 TRANSPORT PROTEIN X - RAY STRUCTURE OF THE S439T HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH PAROXETINE AT THE CENTRAL SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; FRAGMENT: RESIDUES 76 - 618; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.62A 25.60% FAB 06-SEP-17 20170906 TRANSPORT PROTEIN X - RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH SERTRALINE AT THE CENTRAL SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.53A 26.30% FAB 06-SEP-17 20170906 TRANSPORT PROTEIN X - RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH FLUVOXAMINE AT THE CENTRAL SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; FRAGMENT: RESIDUES 76 - 618; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 3.80A 24.70% FAB 06-SEP-17 20170906 TRANSPORT PROTEIN ANOMALOUS CHLORIDE SIGNAL REVEALS THE POSITION OF SERTRALINE COMPLEXED WITH THE SEROTONIN TRANSPORTER AT THE CENTRAL SITE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQDVSTAVA 7 SASYRYT 9 QQHYSIPRT 5 DYYMN 17 NINPNNGGTSYNQKFKG 10 SPVRPYYFDY crystal 4.05A 27.10% FAB 06-SEP-17 20170906 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB311 COMPLEX MOLECULE: ACE - ASN - PRO - ASN - ALA - ASN - PRO - ASN - ALA - ASN - PRO - ASN; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGGSSNIGAGYDVH 7 GNINRPS 12 QSYDRRLSGSWV 5 NYGMH 17 IIWYDGSRNFYAASVEG 12 AAYYDTSGYGDY crystal 2.10A 20.50% FAB 07-SEP-17 20170907 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB317 COMPLEX MOLECULE: PEPTIDE ACE - ASN - PRO - ASN - ALA - ASN - PRO - ASN - ALA - ASN - PRO - ASN - ALA - NH2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISRWLA 7 GASVLES 9 QHYNSYFVT 5 TYAMH 17 VISYHSTNKYYEDSVRG 10 DGYSSSFFDF crystal 2.40A 17.80% FAB 07-SEP-17 20170907 IMMUNE SYSTEM STRUCTURE OF CETUXIMAB WITH AMINOHEPTANOIC ACID - LINKED N - OCTYLARGININE MEDITOPE VARIANT MOLECULE: MEDITOPE; ENGINEERED: YES ? IGG HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 18.10% FAB 07-SEP-17 20170907 IMMUNE SYSTEM STRUCTURE OF CETUXIMAB WITH AMINOHEPTANOIC ACID - LINKED N - (3 - AMINOPROPYL) - L - ARGININE MEDITOPE VARIANT MOLECULE: MEDITOPE; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 17.40% FAB 08-SEP-17 20170908 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ASF1 - FAB 12E COMPLEX MOLECULE: HISTONE CHAPERONE ASF1; SYNONYM: ANTI - SILENCING FUNCTION PROTEIN 1,YASF1; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQDGWSLIT 5 SYYSI 17 ASIYPYYGSTSYADSVK 9 RGYGWALDY crystal 2.10A 19.40% FAB 08-SEP-17 20170908 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ASF1 - FAB 12E COMPLEX MOLECULE: HISTONE CHAPERONE ASF1; SYNONYM: ANTI - SILENCING FUNCTION PROTEIN 1,YASF1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSQWYPIT 5 YSSIH 17 YIYPSSGYTSYADSVKG 10 SYSTKLAMDY crystal 2.48A 19.50% FAB 09-SEP-17 20170909 IMMUNE SYSTEM STRUCTURE OF CETUXIMAB WITH AMINOHEPTANOIC ACID - LINKED N - (3 - HYDROXYPROPYL) - L - ARGININE MEDITOPE VARIANT MOLECULE: MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 17.20% FAB 11-SEP-17 20170911 IMMUNE SYSTEM STRUCTURE OF CETUXIMAB WITH AMINOHEPTANOIC ACID - LINKED N - CARBOXYETHYLARGININE MEDITOPE VARIANT MOLECULE: MEDITOPE; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSIGTNIH 7 YASESIS 9 QQNNNWPTT 5 NYGVH 16 VIWSGGNTDYNTPFTS 11 ALTYYDYEFAY crystal 2.48A 17.20% FAB 11-SEP-17 20170911 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE 580 GERMLINE ANTIBODY BOUND TO CIRCUMSPOROZOITE PROTEIN NANP 5 - MER MOLECULE: CIRCUMSPOROZOITE PROTEIN NANP 5 - MER; ENGINEERED: YES; OTHER_DETAILS: CIRCUMSPOROZOITE PROTEIN NANP 5 - MER ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRES 9 QQYYSTPIT 5 SYAMS 17 AISGSGGSTYYADSVKG 16 DPGGDSSPAGRTWFDP crystal 1.60A 16.70% FAB 11-SEP-17 20170911 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEUTRALIZING ANTI - CIRCUMSPOROZOITE PROTEIN 663 ANTIBODY ? ? ? HOMO SAPIENS 15 RSTQSLIFGEHNYLD 7 LASNRAS 9 VQTVQVPYT 5 NYAFN 17 IIYRSGSRMYHADSVKG 12 LLIYESDVGVDF crystal 2.10A 20.70% FAB 13-SEP-17 20170913 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1190 MOLECULE: PFS25; ENGINEERED: YES ? ? HOMO SAPIENS 11 GGSNIGSKSVH 7 YDYDRPS 12 QVWDSSSDHVWV 5 DYYIH 17 WINPTDGGTNYAQKFQD 11 DRITTAAPFDY crystal 2.40A 19.20% ? 13-SEP-17 20170913 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1276 MOLECULE: PFS25; ENGINEERED: YES ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 YDFDRPS 10 QVWDSDRYWV 5 DYYIH 17 WINPNSGGTNYAQNFQD 11 DRITTAAPFDY crystal 2.20A 19.30% ? 14-SEP-17 20170914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1269 MOLECULE: 25 KDA OOKINETE SURFACE ANTIGEN; SYNONYM: PFS25; ENGINEERED: YES ? ? HOMO SAPIENS 12 RTSQSVSSSYLA 7 GASSRAT 6 QQYGNS 5 RNAMN 17 TISGSGDSTYYADSVKG 16 GDYYFDSGSYSFGMDV crystal 2.50A 21.90% ? 14-SEP-17 20170914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1260 MOLECULE: 25 KDA OOKINETE SURFACE ANTIGEN; SYNONYM: PFS25; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSLVYSDGNTYLN 7 KVSNRDS 9 MQATHWPLT 5 SYGFS 17 WISAYNGNTDYSQKLQG 16 DRGDRLYYYYYYGMDV crystal 3.30A 23.30% ? 14-SEP-17 20170914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1245 MOLECULE: 25 KDA OOKINETE SURFACE ANTIGEN; SYNONYM: PFS25; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSLVYSDGNTYLS 7 KVSNRDS 9 MQDTHWPPT 5 SYGIS 17 WISAYNGNRKYAQKVQG 16 DRGDGDYRYYYYGMDV crystal 1.90A 16.50% ? 14-SEP-17 20170914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1262 MOLECULE: PFS25; ENGINEERED: YES; ? ? HOMO SAPIENS 11 WASQGINSYLA 7 AASTLQS 9 QQLNSYPCS 6 SSHWWS 16 EISLSGSTHYGPSLKS 11 ESRFYGAYFDY crystal 2.70A 18.90% ? 14-SEP-17 20170914 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CLEAVAGE - INDEPENDENT PREFUSION HIV ENV GLYCOPROTEIN TRIMER OF THE CLADE A BG505 ISOLATE (NFL CONSTRUCT) IN COMPLEX WITH FABS PGT122 AND PGV19 AT 3.39 A MOLECULE: ENVELOPE GLYCOPROTEIN GP140; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; LAMBDA ? HOMO SAPIENS 13 TASSDFRGFSSVS 7 SVNRRPS 5 NAYEF 5 DFDIH 17 WVRPLGGGVSYARQFQG 11 MGAAREWDFQY crystal 3.40A 33.60% FAB 14-SEP-17 20170914 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CIRCUMSPOROZOITE PROTEIN ATSR DOMAIN IN COMPLEX WITH 1710 ANTIBODY MOLECULE: CIRCUMSPOROZOITE PROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDKLGDKYAC 7 QDTKRPS 9 QAWDSSTVV 5 SYSMN 17 SITSSSSYIYYADSVKG 14 DPGIAAADNHWFDP crystal 1.95A 18.30% ? 15-SEP-17 20170915 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI - CIRCUMSPOROZOITE PROTEIN 1710 ANTIBODY ? ? ? HOMO SAPIENS 11 SGDKLGDKYAC 7 QDTKRPS 9 QAWDSSTVV 5 SYSMN 17 SITSSSSYIYYADSVKG 14 DPGIAAADNHWFDP crystal 1.90A 18.50% ? 15-SEP-17 20170915 RNA / IMMUNE SYSTEM SPINACH RNA APTAMER - FAB BL3 - 6 S TO N MUTANT COMPLEX MOLECULE: RNA (86 - MER); ENGINEERED: YES ? ? MUS MUSCULUS 11 CRASQSVSSAV 7 YSASSLY 10 CQQSYSFPNT 5 YSSIH 17 SISPYSGSTYYADSVKG 13 QGYRRRSGRGFDY crystal 1.64A 21.20% FAB 16-SEP-17 20170916 SIGNALING PROTEIN CRYSTAL STRUCTURE OF A COMPLEX BETWEEN G PROTEIN BETA GAMMA DIMER AND AN INHIBITORY NANOBODY REGULATOR MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INAMG 16 AITRGGRTNYADSVKG 6 GRSRGY crystal 2.34A 20.30% HC-dimer 19-SEP-17 20170919 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV ANTIBODY PGT128 IN COMPLEX WITH A BACTERIALLY DERIVED SYNTHETIC MIMETIC OF MAN9. WITH A BACTERIALLY DERIVED SYNTHETIC MIMETIC OF MAN9. ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.27A 16.50% FAB 21-SEP-17 20170921 SIGNALING PROTEIN 3.3 ANGSTROM PHASE - PLATE CRYO - EM STRUCTURE OF A BIASED AGONIST - BOUND HUMAN GLP - 1 RECEPTOR - GS COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 22-SEP-17 20170922 IMMUNY SYSTEM / RNA SPINACH RNA APTAMER_AGACC MUTANT - FAB BL3 - 6 COMPLEX MOLECULE: RNA (83 - MER) ,RNA (83 - MER); ENGINEERED: YES ? ? MUS MUSCULUS 11 CRASQSVSSAV 7 YSASSLY 10 CQQSYSFPST 5 YSSIH 17 SISPYSGSTYYADSVKG 13 QGYRRRSGRGFDY crystal 2.09A 19.40% FAB 22-SEP-17 20170922 VIRAL PROTEIN / IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF A BROADLY - REACTIVE HUMAN ANTI - HEMAGGLUTININ STALK ANTIBODY (70 - 1F02) IN COMPLEX WITH H5 HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSSNYLA 7 GASNRAT 9 QQYGTSPRT 5 SNAIS 17 NIIAVFGTANYAQKFQG 11 GPYYYGNSHDF crystal 3.92A 28.80% ? 22-SEP-17 20170922 TRANSFERASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF NECITUMUMAB (FAB11F8) IN COMPLEX WITH DOMAIN III FROM A CETUXIMAB RESISTANT VARIANT OF EGFR (SEGFRD3 - S468R) MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; SYNONYM: PROTO - ONCOGENE C - ERBB - 1,RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 1; EC: 2.7.10.1; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 9 HQYGSTPLT 7 SGDYYWS 16 YIYYSGSTDYNPSLKS 11 VSIFGVGTFDY crystal 2.80A 20.90% FAB 23-SEP-17 20170923 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 20 WITH HUMAN PROTECTIVE ANTIBODY CIS43 MOLECULE: PFCSP PEPTIDE 20: ASN - PRO - ASP - PRO - ASN - ALA - ASN - PRO - ASN - VAL; ENGINEERED: YES ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRQS 9 HQYYSSPLT 5 SYAIH 17 WIKAGNGNTRYSQKFQD 12 LTVLTPDDAFDI crystal 2.40A 20.10% FAB 29-SEP-17 20170929 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 21 WITH HUMAN PROTECTIVE ANTIBODY CIS43 MOLECULE: PFCSP PEPTIDE 21: ASN - PRO - ASP - PRO - ASN - ALA - ASN - PRO - ASN - VAL - ASP - PRO - ASN; ENGINEERED: YES ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRQS 9 HQYYSSPLT 5 SYAIH 17 WIKAGNGNTRYSQKFQD 12 LTVLTPDDAFDI crystal 1.79A 20.80% FAB 29-SEP-17 20170929 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 25 WITH HUMAN PROTECTIVE ANTIBODY CIS43 MOLECULE: PFCSP PEPTIDE 25: ASN - VAL - ASP - PRO - ASN - ALA - ASN - PRO - ASN - VAL - ASP; ENGINEERED: YES ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRQS 9 HQYYSSPLT 5 SYAIH 17 WIKAGNGNTRYSQKFQD 12 LTVLTPDDAFDI crystal 1.98A 17.60% FAB 29-SEP-17 20170929 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 29 WITH HUMAN PROTECTIVE ANTIBODY CIS43 MOLECULE: PFCSP PEPTIDE 29: ASN - PRO - ASN - ALA - ASN - PRO - ASN - ALA - ASN; ENGINEERED: YES ? ? HOMO SAPIENS 17 KSSQSVLYSSNNKNYLA 7 WASTRQS 9 HQYYSSPLT 5 SYAIH 17 WIKAGNGNTRYSQKFQD 12 LTVLTPDDAFDI crystal 2.19A 19.50% FAB 29-SEP-17 20170929 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 20 WITH HUMAN ANTIBODY CIS42 MOLECULE: PFCSP PEPTIDE 20: ASN - PRO - ASP - PRO - ASN - ALA - ASN - PRO - ASN - VAL - ASP; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TATSSNVGSFNLVS 7 EVSKRPS 10 CSYVGSDTWV 5 TYAMN 17 WINTNTGNPTYAPGFTG 10 VYSYGVPFDY crystal 2.30A 23.80% FAB 29-SEP-17 20170929 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 21 WITH HUMAN ANTIBODY CIS42 MOLECULE: PFCSP PEPTIDE 21: ASN - PRO - ASP - PRO - ASN - ALA - ASN - PRO - ASN - VAL - ASP - PRO - ASN; ENGINEERED: YES ? ? HOMO SAPIENS 14 TATSSNVGSFNLVS 7 EVSKRPS 10 CSYVGSDTWV 5 TYAMN 17 WINTNTGNPTYAPGFTG 10 VYSYGVPFDY crystal 1.78A 19.30% FAB 29-SEP-17 20170929 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 25 WITH HUMAN ANTIBODY CIS42 MOLECULE: PFCSP PEPTIDE 25: ASN - VAL - ASP - PRO - ASN - ALA - ASN - PRO - ASN - VAL - ASP - PRO - ASN; ENGINEERED: YES ? ? HOMO SAPIENS 14 TATSSNVGSFNLVS 7 EVSKRPS 10 CSYVGSDTWV 5 TYAMN 17 WINTNTGNPTYAPGFTG 10 VYSYGVPFDY crystal 1.98A 16.90% FAB 29-SEP-17 20170929 IMMUNE SYSTEM STRUCTURE OF PFCSP PEPTIDE 29 WITH HUMAN ANTIBODY CIS42 MOLECULE: PFCSP PEPTIDE 29: ALA - ASN - PRO - ASN - ALA - ASN - PRO - ASN - ALA - ASN - PRO - ASN - ALA; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TATSSNVGSFNLVS 7 EVSKRPS 10 CSYVGSDTWV 5 TYAMN 17 WINTNTGNPTYAPGFTG 10 VYSYGVPFDY crystal 2.22A 18.50% FAB 29-SEP-17 20170929 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE APO ANTIBODY FRAGMENT (FAB) RAISED AGAINST C - TERMINAL DOMAIN OF EBOLA NUCLEOPROTEIN (EBOV, TAFV, BDBV STRAINS) ? ? ? HOMO SAPIENS 11 RASQSVSSAVA 1 S 9 QQYSYSLVT 5 YYYIH 17 SISPYYGYTSYADSVKG 9 WSYKSGMDY crystal 2.11A 20.50% FAB 03-OCT-17 20171003 HYDROLASE / IMMUNE SYSTEM / HORMONE CRYO - EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11 - E HEAVY CHAIN, FAB H11 - E LIGHT CHAIN AND INSULIN MOLECULE: INSULIN - DEGRADING ENZYME; FRAGMENT: RESIDUES 46 - 1011; SYNONYM: ABETA - DEGRADING PROTEASE,INSULIN PROTEASE,INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSYFNPIT 5 SSSIH 17 SIYSYSGSTYYADSVKG 10 HYSAVAGLDY ElectronMicroscopy N/A N/A FAB 03-OCT-17 20171003 MEMBRANE PROTEIN / AGONIST CRYSTAL STRUCTURE OF A NANOBODY - STABILIZED ACTIVE STATE OF THE KAPPA - OPIOID RECEPTOR MOLECULE: SOLUBLE CYTOCHROME B562, KAPPA - TYPE OPIOID RECEPTOR; FRAGMENT: UNP RESIDUES 23 - 128; UNP RESIDUES 54 - 358; SYNONYM: CYTOCHROME B - 562,KOR - 1; ENGINEERED: YES; MUTATION: YES; KAPPA ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 3 PMG 17 SITWSGIDPTYADSVAD 15 RAPVGQSSSPYDYDY crystal 3.10A 25.50% HC-dimer 03-OCT-17 20171003 HYDROLASE / IMMUNE SYSTEM CRYO - EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11 HEAVY CHAIN AND FAB H11 LIGHT CHAIN MOLECULE: INSULIN - DEGRADING ENZYME; FRAGMENT: RESIDUES 46 - 1011; SYNONYM: ABETA - DEGRADING PROTEASE,INSULIN PROTEASE,INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSYFNPIT 5 SSSIH 17 SIYSYSGSTYYADSVKG 10 HYSAVAGLDY ElectronMicroscopy N/A N/A FAB 05-OCT-17 20171005 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV138 MOLECULE: IMV MEMBRANE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVTSTYLA 7 SASSRAT 10 QQYGSSPPYT 5 DYYMH 17 LVDPQEGETTYAEKFQG 8 ESFGIPHF crystal 2.90A 24.30% FAB 10-OCT-17 20171010 IMMUNE SYSTEM TRASTUZUMAB FAB V3 IN COMPLEX WITH 5 - PHENYL MEDITOPE VARIANT MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.14A 17.30% FAB 11-OCT-17 20171011 IMMUNE SYSTEM TRASTUZUMAB FAB V3 MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; ENGINEERED: YES ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.82A 16.60% FAB 11-OCT-17 20171011 IMMUNE SYSTEM POTENT AND SELECTIVE ANTITUMOR ACTIVITY OF A T - CELL ENGAGING BISPECIFIC ANTIBODY TARGETING A MEMBRANE - PROXIMAL EPITOPE OF ROR1 MOLECULE: VARIABLE DOMAIN HEAVY CHAIN, ANTIBODY R11; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQSIDSNLA 7 RASNLAS 12 LGGVGNVSYRTS 0 N/A 0 N/A 0 N/A crystal 1.62A 19.40% LC-dimer 12-OCT-17 20171012 IMMUNE SYSTEM TRASTUZUMAB FAB V3 IN COMPLEX WITH CQFDLSTRRLKC MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; ENGINEERED: YES; KAPPA ? MUS MUSCULUS, HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.14A 17.60% FAB 12-OCT-17 20171012 IMMUNE SYSTEM TRASTUZUMAB FAB V3 WITH 5 - DIPHENYL MEDITOPE VARIANT MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; ENGINEERED: YES; KAPPA ? MUS MUSCULUS, HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.90A 16.60% FAB 12-OCT-17 20171012 IMMUNE SYSTEM POTENT AND SELECTIVE ANTITUMOR ACTIVITY OF A T - CELL ENGAGING BISPECIFIC ANTIBODY TARGETING A MEMBRANE - PROXIMAL EPITOPE OF ROR1 MOLECULE: VARIABLE DOMAIN R11 HEAVY CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 CQASQSIDSNL 7 YRASNLA 13 CLGGVGNVSYRTS 0 N/A 0 N/A 0 N/A crystal 1.95A 16.20% LC-dimer 14-OCT-17 20171014 IMMUNE SYSTEM FAB / EPITOPE COMPLEX OF MOUSE MONOCLONAL ANTIBODY C5.2 TARGETING A PHOSPHO - TAU EPITOPE. MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? ? MUS MUSCULUS 11 QASQDTSINLN 7 GASNLED 9 LQHTYLPFT 5 DRTIH 17 YIYPGDDSTKYNDMFKA 6 RGTMDY crystal 2.10A 21.80% FAB 16-OCT-17 20171016 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY N49P7 IN COMPLEX WITH HIV - 1 CLADE AE STRAIN 93TH057 GP120 CORE. MOLECULE: CLADE A / E 93TH057 HIV - 1 GP120 CORE; ENGINEERED: YES; MUTATION: YES; ? IGG HOMO SAPIENS 8 TGTHNLVS 7 DFNKRPS 5 WAYEA 5 DYIIH 17 WMNPMGGQVNIPWKFQG 19 DRSNGSGKRFESSNWFLDL crystal 2.70A 22.80% FAB 20-OCT-17 20171020 MEMBRANE PROTEIN ADAM10 EXTRACELLULAR DOMAIN BOUND BY THE 11G2 FAB MOLECULE: DISINTEGRIN AND METALLOPROTEINASE DOMAIN - CONTAINING PROTEIN 10; SYNONYM: ADAM 10,CDW156,KUZBANIAN PROTEIN HOMOLOG,MAMMALIAN DISINTEGRIN - METALLOPROTEASE; EC: 3.4.24.81; ENGINEERED: YES ? ? MUS MUSCULUS 12 TVSSSVSSGYLH 7 STSNLAS 9 HQYRRSPLT 5 GYGVN 16 VIWGDGTTDYNSTLKS 9 DGDYGRLDY crystal 3.10A 26.70% FAB 24-OCT-17 20171024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A POLYSACCHARIDE - BINDING HUMAN FAB (F598) ? ? ? HOMO SAPIENS 12 TLSSGHSNYAIA 7 VNRDGSH 13 DYYCQTWGAGIRV 5 GYYWS 16 YIHYSRSTNSNPALKS 16 DTYYYDSGDYEDAFDI crystal 1.70A 17.20% FAB 24-OCT-17 20171024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A POLYSACCHARIDE - BINDING HUMAN FAB (F598) IN COMPLEX WITH N - ACETYL - D - GLUCOSAMINE (GLCNAC) WITH N - ACETYL - D - GLUCOSAMINE (GLCNAC) ? ? HOMO SAPIENS 12 TLSSGHSNYAIA 7 VNRDGSH 13 DYYCQTWGAGIRV 5 GYYWS 16 YIHYSRSTNSNPALKS 16 DTYYYDSGDYEDAFDI crystal 1.60A 16.70% FAB 24-OCT-17 20171024 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A POLYSACCHARIDE - BINDING HUMAN FAB (F598) IN COMPLEX WITH NONA - N - ACETYL - D - GLUCOSAMINE (9NAC) WITH NONA - N - ACETYL - D - GLUCOSAMINE (9NAC) ? ? HOMO SAPIENS 12 TLSSGHSNYAIA 7 VNRDGSH 13 DYYCQTWGAGIRV 5 GYYWS 16 YIHYSRSTNSNPALKS 16 DTYYYDSGDYEDAFDI crystal 1.90A 16.60% FAB 24-OCT-17 20171024 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 CLADE AE STRAIN CNE55 GP120 CORE IN COMPLEX WITH NEUTRALIZING ANTIBODY VRC - PG05 THAT TARGETS THE CENTER OF THE SILENT FACE ON THE OUTER DOMAIN OF GP120 MOLECULE: HIV - 1 CLADE AE GP120 CORE; ENGINEERED: YES; ? ? HOMO SAPIENS 17 KSSQSVLYRPNNRNYVA 7 WASFRES 8 QQYFFLYS 5 RDWMT 17 NINMDGDKKDYVDSVKG 17 IRQVSKYLQWYPGVFEM crystal 2.38A 19.40% FAB 25-OCT-17 20171025 HYDROLASE / IMMUNE SYSTEM CRYO - EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11 - E HEAVY CHAIN, FAB H11 - E LIGHT CHAIN MOLECULE: INSULIN - DEGRADING ENZYME; FRAGMENT: RESIDUES 46 - 1011; SYNONYM: ABETA - DEGRADING PROTEASE,INSULIN PROTEASE,INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSYFNPIT 5 SSSIH 17 SIYSYSGSTYYADSVKG 10 HYSAVAGLDY ElectronMicroscopy N/A N/A FAB 26-OCT-17 20171026 HYDROLASE / IMMUNE SYSTEM CRYO - EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11 - E HEAVY CHAIN, FAB H11 - E LIGHT CHAIN MOLECULE: INSULIN - DEGRADING ENZYME; FRAGMENT: RESIDUES 46 - 1011; SYNONYM: ABETA - DEGRADING PROTEASE,INSULIN PROTEASE,INSULINASE, INSULYSIN; EC: 3.4.24.56; ENGINEERED: YES; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQSYFNPIT 5 SSSIH 17 SIYSYSGSTYYADSVKG 10 HYSAVAGLDY ElectronMicroscopy N/A N/A FAB 26-OCT-17 20171026 IMMUNE SYSTEM THE MECHANISM OF GM - CSF INHIBITION BY HUMAN GM - CSF AUTO - ANTIBODIES MOLECULE: GRANULOCYTE - MACROPHAGE COLONY - STIMULATING FACTOR; SYNONYM: GM - CSF,COLONY - STIMULATING FACTOR,CSF,MOLGRAMOSTIN, SARGRAMOSTIM; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGINRRLA 7 AVSTLQS 9 LQSNNYPLT 5 KYYWS 16 YIYASGSSFYNPSFKS 7 ITGTTDL crystal 2.60A 23.20% FAB 26-OCT-17 20171026 IMMUNE SYSTEM THE MECHANISM OF GM - CSF INHIBITION BY HUMAN GM - CSF AUTO - ANTIBODIES MOLECULE: GRANULOCYTE - MACROPHAGE COLONY - STIMULATING FACTOR; SYNONYM: GM - CSF,COLONY - STIMULATING FACTOR,CSF,MOLGRAMOSTIN, SARGRAMOSTIM; ENGINEERED: YES ? ? MUS MUSCULUS 11 HASQNINVWLS 7 KASNLHT 9 QQGQSYPLT 5 NYYMH 17 WIFPGSDNTKYNEKFKG 8 KGTTGFAY crystal 2.00A 18.50% FAB 26-OCT-17 20171026 IMMUNE SYSTEM STRUCTURE OF BEVACIZUMAB FAB MUTANT IN COMPLEX WITH VEGF MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR A; FRAGMENT: UNP RESIDUES 214 - 315; SYNONYM: VEGF - A, VASCULAR PERMEABILITY FACTOR, VPF; ENGINEERED: YES ? ? HOMO SAPIENS 11 SASQDISNYLN 7 FTDDLHS 9 QQYSTVPWT 5 NYGMN 17 WINTYTGEPTYAADFKR 14 YPHYYGSSHWYFDV crystal 2.55A 17.30% FAB 27-OCT-17 20171027 TRANSFERASE / IMMUNE SYSTEM STRUCTURE OF TRASTUZUMAB FAB MUTANT IN COMPLEX WITH HER2 EXTRACELLULAR DOMAIN MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; FRAGMENT: UNP RESIDUES 1 - 652; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN, MLN 19, PROTO - ONCOGENE NEU, PROTO - ONCOGENE C - ERBB - 2, TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2, P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SADFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.70A 20.70% FAB 29-OCT-17 20171029 IMMUNE SYSTEM MOUSE IMMUNOGLOBULIN G 2C FC FRAGMENT WITH COMPLEX - TYPE GLYCAN ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGH; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.05A 23.90% FC 31-OCT-17 20171031 IMMUNE SYSTEM MOUSE IMMUNOGLOBULIN G 2C FC FRAGMENT WITH SINGLE GLCNAC ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: MOUSE; ORGANISM_TAXID: 10090; GENE: IGH; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.04A 21.30% FC 31-OCT-17 20171031 IMMUNE SYSTEM TRASTUZUMAB FAB D185A (LIGHT CHAIN) MUTANT. ? ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.75A 16.90% FAB 31-OCT-17 20171031 IMMUNE SYSTEM TRASTUZUMAB FAB N158A, D185A, K190A (LIGHT CHAIN) TRIPLE MUTANT. ? ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.06A 20.00% FAB 31-OCT-17 20171031 IMMUNE SYSTEM TRASTUZUMAB FAB D185A (LIGHT CHAIN) MUTANT BIOTIN CONJUGATION. ? ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 1.80A 16.80% FAB 31-OCT-17 20171031 IMMUNE SYSTEM SIRPALPHA ANTIBODY COMPLEX MOLECULE: TYROSINE - PROTEIN PHOSPHATASE NON - RECEPTOR TYPE SUBSTRATE 1; SYNONYM: SHPS - 1,BRAIN IG - LIKE MOLECULE WITH TYROSINE - BASED ACTIVATION MOTIFS,BIT,CD172 ANTIGEN - LIKE FAMILY MEMBER A,INHIBITORY RECEPTOR SHPS - 1,MACROPHAGE FUSION RECEPTOR,MYD - 1 ANTIGEN,SIGNAL - REGULATORY PROTEIN ALPHA - 1,SIRP - ALPHA - 1,SIGNAL - REGULATORY PROTEIN ALPHA - 2,SIRP - ALPHA - 2,SIGNAL - REGULATORY PROTEIN ALPHA - 3,SIRP - ALPHA - 3,P84; ENGINEERED: YES ? ? MUS MUSCULUS 12 CTATSLIPVGPI 7 QKEGHFP 15 CVKFRKGSPDDVEFK 5 DYYIH 17 RIDPEDGETKYAPKFQD 4 WGAY crystal 2.19A 21.20% FAB 03-NOV-17 20171103 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY CONTAINING THE FLUORESCENT NON - CANONICAL AMINO ACID L - (7 - HYDROXYCOUMARIN - 4 - YL) ETHYLGLYCINE AT PH 5.5 ? ? ? HOMO SAPIENS 15 RASQRVSSSTYSYMH 7 YASNLES 8 QHSWEPPT 5 SYYMY 17 EINPSNGDTNFNEKFKS 9 SDGRNDMDS crystal 1.45A 12.40% FAB 07-NOV-17 20171107 IMMUNE SYSTEM STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3A MOLECULE: POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RASQSVSGSYLA 7 GASNRAT 8 QQYGSSPT 3 SIN 17 TFIPMFGTSKYAQKFQG 18 PETPRYCSGGFCYGEFDN crystal 2.80A 23.20% FAB 08-NOV-17 20171108 IMMUNE SYSTEM STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3B MOLECULE: POLYPROTEIN; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPQT 4 EPVT 17 GIIPAFGVTKYAQKFQG 19 VGLRGIVMVGGLAMNWLDP crystal 2.60A 23.40% FAB 08-NOV-17 20171108 IMMUNE SYSTEM STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3D MOLECULE: POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 12 RAGQTVASNSLA 7 GASIRAS 6 QQYGST 5 SYVIT 17 AIIPFFGTTNLAQKFQG 22 AGDLSVGGVLAGGVPHLRHFDP crystal 3.25A 27.00% FAB 08-NOV-17 20171108 IMMUNE SYSTEM STRUCTURE OF AMM01 FAB, AN ANTI EBV GH / GL NEUTRALIZING ANTIBODY ? ? ? HOMO SAPIENS 11 GGHNIGAKNVH 7 YDSDRPS 13 QVWDSGRGHPLYV 5 HFGIS 17 WIDTNNGNTNYAQSLQG 14 ALEMGHRSGFPFDY crystal 1.55A 16.70% FAB 09-NOV-17 20171109 VIRAL PROTEIN / IMMUNE SYSTEM RSV G CENTRAL CONSERVED REGION BOUND TO FAB CB017.5 MOLECULE: MAJOR SURFACE GLYCOPROTEIN G; SYNONYM: ATTACHMENT GLYCOPROTEIN G,MEMBRANE - BOUND GLYCOPROTEIN,MG; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDAMAEQYTY 7 KDTERPS 11 QSTDSSGTSWV 5 VYAMH 17 IIWYDGSNKYYADSVKG 13 DPIVGHTRDGLDV crystal 2.00A 18.90% FAB 10-NOV-17 20171110 VIRAL PROTEIN / IMMUNE SYSTEM RSV G PEPTIDE BOUND TO FAB CB002.5 MOLECULE: MAJOR SURFACE GLYCOPROTEIN G; SYNONYM: ATTACHMENT GLYCOPROTEIN G,MEMBRANE - BOUND GLYCOPROTEIN,MG; ENGINEERED: YES; OTHER_DETAILS: A PEPTIDE ENCOMPASSING THE RSV G CENTRAL CONSERVED REGION WHICH INCLUDES TWO DISULFIDE BONDS WHICH FORM A CYSTEINE NOOSE. ? ? HOMO SAPIENS 11 RASQSIDNYLN 7 AASGLQS 10 QQSYSTLTWT 5 SYFWN 16 YIYGSGSADYNPSLKS 18 SGFCSDDACYRRGSWFDP crystal 2.12A 17.10% FAB 10-NOV-17 20171110 VIRAL PROTEIN / IMMUNE SYSTEM THERAPEUTIC HUMAN MONOCLONAL ANTIBODY MR191 BOUND TO A MARBURGVIRUS GLYCOPROTEIN MOLECULE: ENVELOPE GLYCOPROTEIN GP2; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGFDVH 7 DNNNRPS 12 QSYDTSLSGPVV 7 DNSYYWG 16 TISYSGNTYYNPSLKS 16 QRIVSGFVEWLSKFDY crystal 3.17A 25.40% FAB 21-NOV-17 20171121 CELL INVASION PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 3E9 MOLECULE: RETICULOCYTE BINDING PROTEIN 2, PUTATIVE; ENGINEERED: YES; ? ? MUS MUSCULUS 11 ITSTDIDDDLN 7 EGNTLRP 9 LQSDNLPLT 5 DHFMH 17 RIDPEDGETKYAPKFQG 11 SGSVSSPWFAY crystal 2.53A 19.50% FAB 22-NOV-17 20171122 IMMUNE SYSTEM PLASMODIUM VIVAX INVASION BLOCKING MONOCLONAL ANTIBODY 4F7 ? ? ? MUS MUSCULUS 11 CKASQNVGTNV 7 YSASYRY 10 CQQYNSYPYT 5 DYYMA 17 NINYDGSTPDYLDSLKS 9 ETVVGSFDY crystal 1.87A 20.70% FAB 22-NOV-17 20171122 CELL INVASION PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 4F7 MOLECULE: RETICULOCYTE BINDING PROTEIN 2, PUTATIVE; ENGINEERED: YES; ? ? MUS MUSCULUS 11 CKASQNVGTNV 7 YSASYRY 10 CQQYNSYPYT 5 DYYMA 17 NINYDGSTPDYLDSLKS 9 ETVVGSFDY crystal 2.66A 20.00% FAB 22-NOV-17 20171122 IMMUNE SYSTEM PLASMODIUM VIVAX INVASION BLOCKING MONOCLONAL ANTIBODY 10B12 ? ? ? MUS MUSCULUS 16 CKSSQSLLDRDGKTYL 7 YLVSKLD 10 CWQGTHFPQT 5 SYWIH 17 EIDPSDSYTNHNQKFRG 2 AF crystal 2.32A 21.40% FAB 22-NOV-17 20171122 CELL INVASION PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 6H1 MOLECULE: RETICULOCYTE BINDING PROTEIN 2, PUTATIVE; ENGINEERED: YES; ? ? MUS MUSCULUS 11 KASQNVGTNVA 7 SASYRNS 9 QQYDSYPYP 6 SDYYMA 17 ASVSYDGSITYYLDSLK 10 RVTVVDSFDY crystal 3.34A 31.90% FAB 22-NOV-17 20171122 IMMUNE SYSTEM MGG4 FAB IN COMPLEX WITH PEPTIDE MOLECULE: N - TERMINAL JUNCTION PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 17 RSSQSVLSSSNNKNYLA 7 WASTRES 9 QQYYTASPF 5 DYGMH 17 LIWYDGSNESYLDSVKG 12 LLVGITTDVFDV crystal 1.77A 16.80% FAB 27-NOV-17 20171127 MEMBRANE PROTEIN CRYO - EM STRUCTURE OF ENAC MOLECULE: SCNN1B; ENGINEERED: YES; OTHER_DETAILS: TRANSMEMBRANE HELICES HAVE BEEN BUILT WITH POLY UNK SINCE THE DENSITY FOR THE TRANSMEMBRANE DOMAIN IS NOT GOOD ENOUGH TO ACCURATELY BUILD A MODEL. RESIDUES THAT HAVE NOT BEEN BUILT IS DUE TO FLEXIBLE AREAS OF THE PROTEIN WHERE DENSITY IS MISSING. THE FULL SEQUENCE IS DESCRIBED IN SEQUENCE DETAILS.; ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 7 XXXXXXX 19 XXXXXXXXXXXXXXXXXXX 4 XXXX ElectronMicroscopy N/A N/A HC-dimer 28-NOV-17 20171128 STRUCTURAL PROTEIN / IMMUNE SYSTEM NOVEL NON - ANTIBODY PROTEIN SCAFFOLD TARGETING CD40L ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: CD40LG, CD40L, TNFSF5, TRAP; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293; MOL_ID: 2; ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; ORGANISM_TAXID: 562; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.82A 23.00% HC-dimer 30-NOV-17 20171130 VIRUS / IMMUNE SYSTEM HIGH - RESOLUTION STRUCTURE ANALYSIS OF ANTIBODY V5 AND U4 CONFORMATIONAL EPITOPE ON HUMAN PAPILLOMAVIRUS 16 MOLECULE: MAJOR CAPSID PROTEIN L1; ? ? MUS MUSCULUS 17 KSSQSLLYSNTQKNYLA 7 WASTRES 9 QQYYSYPLT 5 SYAMS 16 SISSGGNTHYPDSVKG 14 GLYYGYDEGSDFDY ElectronMicroscopy N/A N/A FAB 04-DEC-17 20171204 VIRUS HIGH - RESOLUTION STRUCTURE ANALYSIS OF ANTIBODY V5 CONFORMATIONAL EPITOPE ON HUMAN PAPILLOMAVIRUS 16 MOLECULE: MAJOR CAPSID PROTEIN L1; ? ? MUS MUSCULUS 17 KSSQSLLDSRNQKNYLA 7 FASTRES 9 QQHYSTPLT 5 SYWMQ 17 AIYPGDGDTWYTQKFKG 13 PPYYYGTTYYFDY ElectronMicroscopy N/A N/A FAB 05-DEC-17 20171205 ANTIVIRAL PROTEIN CRYSTAL STRUCTURE OF PAN - H7, ANTI - HEMAGGLUTININ MONOCLONAL ANTIBODY H7.5 (FAB FRAGMENT) ? ? ? HOMO SAPIENS 11 RPSQSISTFLN 7 DASSLQS 9 QQSFSTPYT 5 RYYFH 17 IINPNGGGTSYAQKFGD 15 DMPYYHDSGGPLFDL crystal 2.00A 20.00% FAB 06-DEC-17 20171206 MEMBRANE PROTEIN CLOSED AND DEEP - INACTIVATED CONFORMATION OF KCSA - T75A MUTANT MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.35A 22.20% ? 19-DEC-17 20171219 MEMBRANE PROTEIN OPEN AND CONDUCTIVE CONFORMATION OF KCSA - T75A MUTANT MOLECULE: PH - GATED POTASSIUM CHANNEL KCSA; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.37A 20.60% ? 19-DEC-17 20171219 IMMUNE SYSTEM HUMAN IGG1 LACKING COMPLEMENT - DEPENDENT CYTOTOXICITY: HU3S193 FC MUTANT K322A ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: 293F; EXPRESSION_SYSTEM_PLASMID: PEE6.4 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 21.60% FC 22-DEC-17 20171222 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY 19B3 MOLECULE: E2 AS412 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 15 RSSESVDAHGYSFLH 7 LASNLES 9 LKNNEDPWT 5 SGYWN 16 YISYSGGNYYNPSLRS 10 LSDSLYAMDC crystal 2.70A 26.60% ? 26-DEC-17 20171226 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE GL PRECURSOR OF THE BROADLY NEUTRALIZING ANTIBODY 19B3 MOLECULE: E2 AS412 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 LASNLES 9 QQNNEDPWT 5 SGYWN 16 YISYSGSTYYNPSLKS 10 LYDGYYAMDY crystal 2.65A 20.10% ? 26-DEC-17 20171226 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE GL PRECURSOR OF THE BROADLY NEUTRALIZING ANTIBODY AP33 MOLECULE: E2 AS412 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASESVDSYGNSFMH 7 LASNLES 9 QQNNEDPWT 5 SGYWN 16 YISYSGSTYYNPSLKS 10 ITTAYYAMDY crystal 2.20A 21.30% ? 26-DEC-17 20171226 IMMUNE SYSTEM STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412 - 423 BOUND TO THE 22D11 BROADLY NEUTRALIZING ANTIBODY MOLECULE: E2 AS412 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 AASNQGS 9 QQSKEVPYT 5 SYGVH 16 AIWSAGNTNYNSALMS 12 APIYYDYTWFAY crystal 1.60A 19.00% ? 26-DEC-17 20171226 MEMBRANE PROTEIN ZEBRAFISH SLC38A9 WITH ARGININE BOUND IN THE CYTOSOL OPEN STATE MOLECULE: SODIUM - COUPLED NEUTRAL AMINO ACID TRANSPORTER 9; SYNONYM: SOLUTE CARRIER FAMILY 38 MEMBER 9; ENGINEERED: YES; OTHER_DETAILS: MEMBRANE PROTEIN ? ? MUS MUSCULUS 14 QASNNITTYSSFIF 7 DSSTLES 11 EDLQYNGEVRT 5 DYVMN 17 SINTSNGYTTYISAFKG 13 NARNFRGNGAMDY crystal 3.17A 26.70% FAB 28-DEC-17 20171228 IMMUNE SYSTEM, SUGAR BINDING PROTEIN S25 - 5 FAB IN COMPLEX WITH CHLAMYDIACEAE - SPECIFIC LPS ANTIGEN WITH CHLAMYDIACEAE - SPECIFIC LPS ANTIGEN KAPPA ? MUS MUSCULUS 16 RSSQTIVHSNGNTYLE 7 KVSNRFY 9 FQGSHVPYT 5 TYGVH 16 VIWSGGSTDYNAAFIS 10 MRITTDWFAY crystal 1.99A 18.90% FAB 16-JAN-18 20180116 SUGAR BINDING PROTEIN UNLIGANDED S25 - 5 FAB ? KAPPA IGG1 MUS MUSCULUS 16 RSSQTIVHSNGNTYLE 7 KVSNRFY 9 FQGSHVPYT 5 TYGVH 16 VIWSGGSTDYNAAFIS 10 MRITTDWFAY crystal 1.89A 19.50% FAB 16-JAN-18 20180116 IMMUNE SYSTEM, SUGAR BINDING PROTEIN S25 - 23 FAB IN COMPLEX WITH CHLAMYDIACEAE LPS (CRYSTAL FORM 1) WITH CHLAMYDIACEAE LPS (CRYSTAL FORM 1) KAPPA IGG1 MUS MUSCULUS 16 RSSQTIVHKNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 TYGVH 16 VIWSGGTTEYNAAFIS 10 MRITTDWFAY crystal 2.29A 19.60% FAB 16-JAN-18 20180116 SUGAR BINDING PROTEIN S25 - 23 FAB IN COMPLEX WITH CHLAMYDIACEAE LPS (CRYSTAL FORM 2) WITH CHLAMYDIACEAE LPS (CRYSTAL FORM 2) KAPPA IGG1 MUS MUSCULUS 16 RSSQTIVHKNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 TYGVH 16 VIWSGGTTEYNAAFIS 10 MRITTDWFAY crystal 1.75A 19.00% FAB 16-JAN-18 20180116 VIRAL PROTEIN AN ANTI - GH / GL ANTIBODY THAT NEUTRALIZES DUAL - TROPIC INFECTION DEFINES A SITE OF VULNERABILITY ON EPSTEIN - BARR VIRUS MOLECULE: ENVELOPE GLYCOPROTEIN L; SYNONYM: GL; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGHNIGAKNVH 7 YDSDRPS 13 QVWDSGRGHPLYV 5 HFGIS 17 WIDTNNGNTNYAQSLQG 14 ALEMGHRSGFPFDY ElectronMicroscopy N/A N/A FAB 16-JAN-18 20180116 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF THE MITOCHONDRIAL CALCIUM UNIPORTER MOLECULE: CALCIUM UNIPORTER; ENGINEERED: YES; ? ? ESCHERICHIA COLI K-12 0 N/A 0 N/A 0 N/A 5 PHYMG 16 GIGFGTTTNYANSVKG 10 RLYPILGHTY crystal 3.10A 25.80% HC-dimer 17-JAN-18 20180117 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MIDDLE - EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS NEUTRALIZING ANTIBODY JC57 - 14 ISOLATED FROM A VACCINATED RHESUS MACAQUE. MOLECULE: JC57 - 14 HEAVY CHAIN; ENGINEERED: YES; ? ? MACACA MULATTA 11 RASQDINNYLS 7 YASSLET 9 QQYNNSPYS 5 SNYWS 17 RFSGSGGSTDFNPSLKS 8 TYSGTFDY crystal 1.99A 17.80% ? 19-JAN-18 20180119 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MIDDLE - EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS NEUTRALIZING ANTIBODY JC57 - 14 ISOLATED FROM A VACCINATED RHESUS MACAQUE IN COMPLEX WITH MERS RECEPTOR BINDING DOMAIN MOLECULE: SPIKE GLYCOPROTEIN; FRAGMENT: RECEPTOR BINDING DOMAIN RESIDUES 381 - 588; SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; ENGINEERED: YES ? ? MACACA MULATTA 11 RASQDINNYLS 7 YASSLET 9 QQYNNSPYS 5 SNYWS 17 RFSGSGGSTDFNPSLKS 8 TYSGTFDY crystal 3.32A 23.40% ? 19-JAN-18 20180119 IMMUNE SYSTEM CRYSTAL STRUCTURE OF POTENT NEUTRALIZING ANTIBODY CDC2 - C2 IN COMPLEX WITH MERS - COV S1 RBD MOLECULE: SPIKE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLLHSNGYNYLD 7 LGSNRAS 8 MQALQTPA 5 IYAIS 17 GIIPIFGTANYAQKFQG 18 EGGHQGYCSGGSCYDFDY crystal 2.10A 19.30% ? 19-JAN-18 20180119 TRANSFERASE / IMMUNE SYSTEM CRYSTAL STRUCTURE OF [KS3] [AT3] DIDOMAIN FROM MODULE 3 OF 6 - DEOXYERTHRONOLIDE B SYNTHASE IN COMPLEX WITH ANTIBODY FRAGMENT (FAB) MOLECULE: 6 - DEOXYERYTHRONOLIDE - B SYNTHASE ERYA2, MODULES 3 AND 4; FRAGMENT: [KS3] [AT3] DIDOMAIN FROM MODULE 3; SYNONYM: DEBS 2,6 - DEOXYERYTHRONOLIDE B SYNTHASE II,ERYTHRONOLIDE SYNTHASE,ORF B; EC: 2.3.1.94; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLLHSNGYNYLD 7 LGSNRAS 10 MQSLQTPRLT 5 DYAMS 19 FIRSKAYGGTTEYAASVKG 7 GGTLFDY crystal 2.09A 16.70% FAB 28-JAN-18 20180128 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF A LIGAND BOUND LACY / NANOBODY COMPLEX MOLECULE: LACTOSE PERMEASE; FRAGMENT: FULL; SYNONYM: LACTOSE - PROTON SYMPORT; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TFNMG 17 AIRWTGGRAYYGDSVKG 16 QGTNGGGYSEATSYNY crystal 3.00A 27.70% HC-dimer 29-JAN-18 20180129 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PCT64_35S, A BROADLY NEUTRALIZING ANTI - HIV ANTIBODY. MOLECULE: PCT64_35S LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RATQSVGGDYFA 7 GTSRRAA 8 RQYETSFT 5 EAWMT 19 HMRPTTEGGAKDYAAAVRG 22 GVERGDFWSDDSQHYNTYLIDV crystal 2.43A 20.40% ? 29-JAN-18 20180129 IMMUNE SYSTEM CRYSTAL STRUCTURE OF PCT64_13C, A STRAIN SPECIFIC ANTI - HIV ANTIBODY MOLECULE: PCT64_13C LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSNNYLA 7 GASSRAT 8 QQSARSFT 5 NAWLD 19 RIKSKTDGGTTDHAAPVKG 22 GVETYDFWSGYDDHYDYYFKDV crystal 1.64A 17.00% ? 29-JAN-18 20180129 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB PCT64_LMCA (SAR) , THE LEAST MUTATED COMMON ANCESTOR OF THE HIV - 1 BROADLY NEUTRALIZING ANTIBODY LINEAGE PCT64 ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 8 QQSARSFT 5 NAWMS 19 RIKSKTDGGTTDYAAPVKG 21 GVETYDFWSGDDHYDYYFRDV crystal 2.70A 24.30% FAB 29-JAN-18 20180129 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DH270.3 FAB IN COMPLEX WITH MAN9 WITH MAN9 ? ? HOMO SAPIENS 14 TGSSSDVGSYNLVS 7 EVNKWAS 10 SSSTNSATVI 5 DYYVH 17 WINPTSGRTISPRKFQG 18 GGWISLYVDYSYYPNFDS crystal 2.85A 20.50% FAB 03-FEB-18 20180203 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SINGLE CHAIN VARIABLE FRAGMENT OF THE DH270.6 BNAB IN COMPLEX WITH THE MAN9 - V3 GLYCOPEPTIDE MOLECULE: MAN9 - V3 GLYCOPEPTIDE; ENGINEERED: YES; ? ? HOMO SAPIENS 13 APSGYTFTDFYIH 7 MNPQTGR 15 DTAIYYCTTGGWISL 5 DFYIH 17 WMNPQTGRTNTARNFQG 26 GGWISLYYDSSYYPNFDHWGQGTLLT crystal 2.17A 22.40% scFv 03-FEB-18 20180203 STRUCTURAL PROTEIN CRYSTAL STRUTCURE OF BRIL BOUND TO AN AFFINITY MATURED SYNTHETIC ANTIBODY. MOLECULE: BRIL; SYNONYM: CYTOCHROME B - 562; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 10 QQYLYYSLVT 5 VDFSL 17 AYISSSSGSTSYADSVK 16 RWGYWPGEPWWKAFDY crystal 1.87A 19.50% FAB 05-FEB-18 20180205 VIRAL PROTEIN CRYSTAL STRUCTURE OF 253 - 11 SOSIP TRIMER IN COMPLEX WITH 10 - 1074 FAB MOLECULE: GLYCOPROTEIN 41; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 GRQALGSRAVQ 7 NNQDRPS 15 YYCHMWDSRSGFSWS 5 NYYWT 16 YISDRESATYNPSLNS 24 ARRGQRIYGVVSFGEFFYYYSMDV crystal 6.50A 30.50% FAB 06-FEB-18 20180206 VIRAL PROTEIN CRYO - EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE - ELICITED ANTIBODY VFP20.01 IN COMPLEX WITH HIV - 1 ENV BG505 DS - SOSIP, AND ANTIBODIES VRC03 AND PGT122 MOLECULE: GLYCOPROTEIN 120; ENGINEERED: YES ? ? HOMO SAPIENS 11 GEESLGSRSVI 7 NNNDRPS 15 YYCHIWDSRRPTNWV 5 DNYWS 16 YVHDSGDTNYNPSLKS 24 TKHGRRIYGVVAFKEWFTYFYMDV ElectronMicroscopy N/A N/A ? 08-FEB-18 20180208 VIRAL PROTEIN CRYO - EM STRUCTURE AT 3.6 A RESOLUTION OF VACCINE - ELICITED ANTIBODY VFP16.02 IN COMPLEX WITH HIV - 1 ENV BG505 DS - SOSIP, AND ANTIBODIES VRC03 AND PGT122 MOLECULE: GLYCOPROTEIN GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GEESLGSRSVI 7 NNNDRPS 15 YYCHIWDSRRPTNWV 5 DNYWS 16 YVHDSGDTNYNPSLKS 24 TKHGRRIYGVVAFKEWFTYFYMDV ElectronMicroscopy N/A N/A ? 08-FEB-18 20180208 IMMUNE SYSTEM STRUCTURE OF VACCINE - ELICITED HIV - 1 NEUTRALIZING ANTIBODY VFP7.04 IN COMPLEX WITH HIV - 1 FUSION PEPTIDE RESIDUE 512 - 519 MOLECULE: HIV FUSION PEPTIDE (512 - 519); ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSIVYSNGNTYLE 7 KVSNRFS 9 FQGSHVPYT 5 DYEMH 17 AIVPETGFTAYTQKFKG 9 LRLYWYFDV crystal 2.41A 18.50% ? 08-FEB-18 20180208 IMMUNE SYSTEM STRUCTURE OF VACCINE - ELICITED HIV - 1 NEUTRALIZING ANTIBODY VFP16.02 IN COMPLEX WITH HIV - 1 FUSION PEPTIDE RESIDUE 512 - 519 MOLECULE: HIV - 1 FUSION PEPTIDE 512 - 519; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQSVVYSDGDTYLE 7 KVSRRFS 9 FQGSHVPYT 5 DYEIH 17 AFDPKSGASASNQKVKG 9 LRYFGYFDV crystal 2.10A 19.60% FAB 08-FEB-18 20180208 IMMUNE SYSTEM VACCINE - ELICITED HIV - 1 NEUTRALIZING ANTIBODY VFP20.01 IN COMPLEX WITH HIV - 1 FUSION PEPTIDE RESIDUE 512 - 519 MOLECULE: HIV - 1 FUSION PEPTIDE 512 - 519; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSIVYKDGNSYLE 7 RVSNRFS 9 FQGTHLPYT 5 DYEMH 17 AIVPETGYTAYNQKFKG 9 LKLLGYFDV crystal 2.46A 21.40% FAB 08-FEB-18 20180208 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF A HIV - 1 CLADE B TIER - 3 ISOLATE H078.14 UFO - BG ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING FABS PGT124 AND 35O22 AT 4.6 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; SYNONYM: ENV POLYPROTEIN,ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 4.60A 31.40% FAB 09-FEB-18 20180209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF RABBIT ANTI - HIV - 1 GP120 V2 FAB 16C2 IN COMPLEX WITH V2 PEPTIDE CONB MOLECULE: HIV - 1 GP120 V2 PEPTIDE CON B; ENGINEERED: YES ? ? ORYCTOLAGUS CUNICULUS 13 QASQSVYSDNWLG 7 AASNLAS 9 AGGFSPNWA 5 NCGVT 17 YIYTGLGVGHYASSVEG 14 DGVMSGVEGYYFNL crystal 2.40A 24.00% FAB 13-FEB-18 20180213 RNA BINDING PROTEIN / RNA CRYSTAL STRUCTURE OF HIV - 1 REV (RESIDUES 1 - 93) - RNA APTAMER COMPLEX MOLECULE: PROTEIN REV; FRAGMENT: UNP RESIDUES 1 - 93; SYNONYM: ART / TRS, ANTI - REPRESSION TRANSACTIVATOR, REGULATOR OF EXPRESSION OF VIRAL PROTEINS; ENGINEERED: YES; ? ? ORYCTOLAGUS CUNICULUS 11 QASQSISSWLS 7 DASNLAS 12 LGGYPAASYRTA 5 GFWLN 17 AIYRGSGSEWYASWAKG 10 DTTDNGYFTI crystal 3.00A 20.80% FAB 13-FEB-18 20180213 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 1) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686C11235; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 21.90% FC 22-FEB-18 20180222 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 3) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686C11235; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.58A 19.50% FC 26-FEB-18 20180226 IMMUNE SYSTEM ANTI HIV FAB 10A ? ? ? ORYCTOLAGUS CUNICULUS 11 QASQSIRSYLA 7 EASKLAS 15 QRNYDSYSGAYYPNG 6 SDYYMC 17 CIWTANSISYYARWAKG 9 GGSGDGQSL crystal 1.80A 16.60% FAB 26-FEB-18 20180226 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 2) ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: DKFZP686C11235; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.44A 21.80% FC 27-FEB-18 20180227 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - INFLUENZA SINGLE - DOMAIN LLAMA ANTIBODY SD38 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IYAMD 16 TSFRDGSTNYADSVKG 16 SLYRDPLGVAGGMGVY crystal 2.05A 17.90% HC-dimer 27-FEB-18 20180227 VIRAL PROTEIN CRYSTAL STRUCTURE OF HIV - 1 CONC_BASE0 PREFUSION ENV TRIMER IN COMPLEX WITH HUMAN ANTIBODY FRAGMENT 3H109L AND 35O22 VARIANTS AT 3.5 ANGSTROM MOLECULE: GP41 ECTODOMAIN OF ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.71A 25.00% FV 27-FEB-18 20180227 VIRAL PROTEIN BG505 SOSIP IN COMPLEX WITH SCD4, 17B, 8ANC195 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH ElectronMicroscopy N/A N/A FAB 02-MAR-18 20180302 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HENDRA VIRUS ATTACHMENT G GLYCOPROTEIN BOUND TO A POTENT CROSS - REACTIVE NEUTRALIZING HUMAN MONOCLONAL ANTIBODY M102.3 MOLECULE: GLYCOPROTEIN G; ENGINEERED: YES; ? IGG HOMO SAPIENS 12 RASQSIRSTYLA 7 GASSRAT 8 QQYGRSPS 5 NYAIN 17 GIIPILGIANYAQKFQG 23 GWGREQLAPHPSQYYYYYYGMDV crystal 2.70A 23.20% ? 05-MAR-18 20180305 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE HENDRA VIRUS ATTACHMENT G GLYCOPROTEIN BOUND TO A POTENT CROSS - REACTIVE NEUTRALIZING HUMAN MONOCLONAL ANTIBODY M102.3 MOLECULE: GLYCOPROTEIN G; ENGINEERED: YES; ? IGG HOMO SAPIENS 12 RASQSIRSTYLA 7 GASSRAT 8 QQYGRSPS 5 NYAIN 17 GIIPILGIANYAQKFQG 23 GWGREQLAPHPSQYYYYYYGMDV crystal 2.72A 19.80% ? 05-MAR-18 20180305 SIGNALING PROTEIN RHODOPSIN - GI COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? UNIDENTIFIED 11 RASQSVSSAVA 7 SASSLYS 9 QQSSSSLIT 5 YSSIH 17 SIYSYSGSTSYADSVKG 19 YPWYWWMEKPYLSLYGMDY ElectronMicroscopy N/A N/A FAB 05-MAR-18 20180305 TRANSPORT PROTEIN STRUCTURE OF THE 2ALPHA3BETA STIOCHIOMETRY OF THE HUMAN ALPHA4BETA2 NICOTINIC RECEPTOR MOLECULE: NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA - 2; ENGINEERED: YES; MUTATION: YES; KAPPA IGG1 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPWT 5 SYWIE 17 EILPGSGSTNYNEKFRG 10 YLPYYYAMDY ElectronMicroscopy N/A N/A ? 08-MAR-18 20180308 TRANSPORT PROTEIN STRUCTURE OF THE 3ALPHA2BETA STIOCHIOMETRY OF THE HUMAN ALPHA4BETA2 NICOTINIC RECEPTOR MOLECULE: NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA - 4; ENGINEERED: YES; MUTATION: YES; KAPPA IGG1 MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPWT 5 SYWIE 17 EILPGSGSTNYNEKFRG 10 YLPYYYAMDY ElectronMicroscopy N/A N/A ? 08-MAR-18 20180308 IMMUNE SYSTEM ADUCANUMAB APO FAB MOLECULE: ADUCANUMAB LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPLT 5 SYGMH 17 VIWFDGTKKYYTDSVKG 15 DRGIGARRGPYYMDV crystal 2.09A 21.20% FAB 08-MAR-18 20180308 VIRAL PROTEIN INFLUENZA B / BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX MOLECULE: ENVELOPE GLYCOPROTEIN; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 13 SGSDSNIGRRSVN 7 SNDQRPS 11 AAWDDSLKGAV 5 TSWMY 16 VINTDGGTYYADSVKG 8 DWGGPEPT crystal 4.10A 24.20% FAB 09-MAR-18 20180309 IMMUNE SYSTEM STRUCTURE OF HUMANIZED SINGLE DOMAIN ANTIBODY SD84 ? ? ? HYBRID 0 N/A 0 N/A 0 N/A 5 TSWMY 16 VINTDGGTYYADSVKG 8 DWGGPEPT crystal 0.92A 12.60% HC-dimer 09-MAR-18 20180309 IMMUNE SYSTEM ADUCANUMAB ABETA COMPLEX MOLECULE: ALA - GLU - PHE - ARG - HIS - ASP; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSYLN 7 AASSLQS 9 QQSYSTPLT 5 SYGMH 17 VIWFDGTKKYYTDSVKG 15 DRGIGARRGPYYMDV crystal 2.38A 18.40% FAB 10-MAR-18 20180310 SIGNALING PROTEIN HETEROTRIMERIC G - PROTEIN IN COMPLEX WITH AN ANTIBODY FRAGMENT MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KLSCSASGFAFSSFGMH 7 ISSGSGT 15 DTAMYYCVRSIYYYG 5 SFGMH 17 YISSGSGTIYYADTVKG 26 SIYYYGSSPFDFWGQGTTLTVSSGGS crystal 2.00A 17.50% scFv 19-MAR-18 20180319 VIRAL PROTEIN GLUTARALDEHYDE - TREATED BG505 SOSIP.664 ENV IN COMPLEX WITH PGV04 FAB MOLECULE: ENVELOPE GLYCOPROTEIN GP160; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; ? ? HUMAN IMMUNODEFICIENCY VIRUS 1 9 TAASYGHMT 7 ATSKRAS 5 QQLEF 6 RTELIH 18 WVKTVTGAVNFGSPDFRQ 14 QKFYTGGQGWYFDL ElectronMicroscopy N/A N/A FAB 19-MAR-18 20180319 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF SODIUM / ALANINE SYMPORTER AGCS WITH L - ALANINE BOUND MOLECULE: SODIUM / ALANINE SYMPORTER AGCS; SYNONYM: ALANINE PERMEASE; ENGINEERED: YES ? ? MUS MUSCULUS 11 RTSENIASALA 7 NAKTLAA 9 QHAAGWLLT 5 DFAMD 15 EIAASERHYAESVKG 7 TAGACGQ crystal 3.24A 23.10% FAB 20-MAR-18 20180320 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF SODIUM / ALANINE SYMPORTER AGCS WITH D - ALANINE BOUND MOLECULE: SODIUM / ALANINE SYMPORTER AGCS; SYNONYM: ALANINE PERMEASE; ENGINEERED: YES ? ? MUS MUSCULUS 11 RTSENIASALA 7 NAKTLAA 9 QHAAGWLLT 5 DFAMD 15 EIAASERHYAESVKG 7 TAGACGQ crystal 3.30A 24.00% FAB 20-MAR-18 20180320 IMMUNE SYSTEM FAB OF ANTI - A - SYNUCLEIN ANTIBODY BIIB054 IN COMPLEX WITH ACETYLATED A - SYNUCLEIN PEPTIDE (1 - 10) MOLECULE: ACE - MET - ASP - VAL - PHE - MET - LYS - GLY - LEU - SER - LYS; ENGINEERED: YES; OTHER_DETAILS: ACETYLATED PEPTIDE ? ? HOMO SAPIENS 11 SGEALPMQFAH 7 KDSERPS 11 QSPDSTNTYEV 5 KAWMS 19 RIKSTADGGTTSYAAPVEG 2 AH crystal 1.90A 18.20% FAB 22-MAR-18 20180322 VIRAL PROTEIN CRYO - EM STRUCTURE AT 4.0 A RESOLUTION OF VACCINE - ELICITED ANTIBODY VFP7.04 IN COMPLEX WITH HIV - 1 ENV BG505 DS - SOSIP, AND ANTIBODIES VRC03 AND PGT122 MOLECULE: ENVELOPE GLYCOPROTEIN GP120; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GEESLGSRSVI 7 NNNDRPS 15 YYCHIWDSRRPTNWV 5 DYSIH 17 WIKPLWGAVSYARQLQG 26 TPADTAEYFCVRRGSCDYCGDFPWQY ElectronMicroscopy N/A N/A ? 26-MAR-18 20180326 VIRAL PROTEIN CRYO - EM STRUCTURE AT 4.2 A RESOLUTION OF VACCINE - ELICITED ANTIBODY VFP1.01 IN COMPLEX WITH HIV - 1 ENV BG505 DS - SOSIP, AND ANTIBODIES VRC03 AND PGT122 MOLECULE: PGT122 LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 10 KASQGGNAMT 7 DTSRRAS 5 QQFEF 5 DNYWS 16 YVHDSGDTNYNPSLKS 24 TKHGRRIYGVVAFKEWFTYFYMDV ElectronMicroscopy N/A N/A ? 26-MAR-18 20180326 GENE REGULATION CRYSTAL STRUCTURE OF A YEAST SAGA TRANSCRIPTIONAL COACTIVATOR ADA2 / GCN5 HAT SUBCOMPLEX, CRYSTAL FORM 1 MOLECULE: TRANSCRIPTIONAL ADAPTER 2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 CRASQSVSSAV 7 YSASSLY 10 CQQSSWYPVT 5 YSSIH 17 SIYPYYGSTSYADSVKG 20 NWYWFGGHFGYYMMPWAMDY crystal 2.67A 25.20% ? 29-MAR-18 20180329 GENE REGULATION CRYSTAL STRUCTURE OF A YEAST SAGA TRANSCRIPTIONAL COACTIVATOR ADA2 / GCN5 HAT SUBCOMPLEX, CRYSTAL FORM 2 MOLECULE: TRANSCRIPTIONAL ADAPTER 2; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQGWANLIT 5 SSYIH 17 SIYSYYGSTYYADSVKG 14 WWQGMYEMGYGMDY crystal 1.98A 20.40% ? 29-MAR-18 20180329 IMMUNE SYSTEM RICIN CATALYTIC SUBUNIT BOUND GO A9 VHH ANTIBODY MOLECULE: RICIN; EC: 3.2.2.22; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 MYMLA 19 AIMCSGGGGGTYYADSMQG 18 STTYCSATTYSSDRLYDF crystal 2.60A 22.60% HC-dimer 30-MAR-18 20180330 IMMUNE SYSTEM ANTI - RTA VHH ANTIBODY ? ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 MYMLA 19 AIMCSGGGGGTYYADSMQG 18 STTYCSATTYSSDRLYDF crystal 1.26A 15.60% HC-dimer 30-MAR-18 20180330 VIRAL PROTEIN / IMMUNE SYSTEM HEPATITIS B CORE - ANTIGEN IN COMPLEX WITH FAB E21 MOLECULE: FAB E21 HEAVY CHAIN; ENGINEERED: YES; ? ? ORYCTOLAGUS CUNICULUS 11 QASQSIGNALA 7 AGSNLAS 10 LGTYSAIDRA 0 N/A 0 N/A 0 N/A crystal 3.15A 23.50% LC-dimer 30-MAR-18 20180330 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 IN COMPLEX WITH GLYCOPEPTIDE 10V1S MOLECULE: 10V1S GLYCOPEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.30A 19.90% FAB 03-APR-18 20180403 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 IN COMPLEX WITH GLYCOPEPTIDE 10F5 WITH GLYCOPEPTIDE 10F5 ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 3.59A 22.00% FAB 03-APR-18 20180403 CELL ADHESION CRYSTAL STRUCTURE OF HUMAN E - CADHERIN BOUND BY MOUSE MONOCLONAL ANTIBODY FAB MAB - 1_19A11 MOLECULE: CADHERIN - 1; SYNONYM: CAM 120 / 80,EPITHELIAL CADHERIN,E - CADHERIN,UVOMORULIN; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KSSQSLLNSSNQKNYLA 7 FTSTRGS 9 QQHYRTPHT 5 RYGVH 16 MMWGGGNTDYNSALKS 11 SNYVLGYAMDY crystal 2.20A 16.40% FAB 04-APR-18 20180404 IMMUNE SYSTEM PCRV FRAGMENT WITH BOUND FAB MOLECULE: TYPE III SECRETION SYSTEM PROTEIN; ENGINEERED: YES; KAPPA IGG1 HOMO SAPIENS 11 RASQGIRNDLG 7 SASTLQS 9 LQDYNYPWT 5 SYAMD 17 AITMSGITAYYTDDVKG 15 EEFLPGTHYFYGMDV crystal 2.78A 21.60% FAB 05-APR-18 20180405 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 1210 FAB IN COMPLEX WITH CIRCUMSPOROZOITE PROTEIN NANP5 MOLECULE: NANP5; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASNLES 8 QQYNNYWT 5 NYGMH 17 VIWYDGSKKYYADSVKG 14 VRDSSDYYGDAFDI crystal 3.20A 20.50% FAB 09-APR-18 20180409 ANTIVIRAL PROTEIN CRYSTAL STRUCTURE OF C05 V110P / A117E MUTANT BOUND TO H3 INFLUENZA HEMAGGLUTININ, HA1 SUBUNIT MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIRKFLN 7 DASNLQR 9 QQYDGLPFT 7 ESTLSYY 17 WLSIINAGGGDIDYADS 26 CAKHMSMQQVPSAGWEREDLVGDAFD crystal 3.25A 25.40% ? 11-APR-18 20180411 IMMUNE SYSTEM CRYSTAL STRUCTURE OF CHIMERIC H.2140 / K.1210 FAB IN COMPLEX WITH CIRCUMSPOROZOITE PROTEIN NANP3 MOLECULE: NANP3; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASNLES 8 QQYNNYWT 5 SYGMH 17 IIWYDGSKKYYADSVKG 15 VGEGQVGDSSGYYDH crystal 1.85A 18.00% FAB 11-APR-18 20180411 IMMUNE SYSTEM CRYSTAL STRUCTURE OF 1450 FAB IN COMPLEX WITH CIRCUMSPOROZOITE PROTEIN NANP5 MOLECULE: NANP5; ENGINEERED: YES ? ? HOMO SAPIENS 11 RATQSINNWLA 7 KASRLES 8 QQYGSSWT 5 NYGMS 17 GISGSSGDTYYADSVKG 16 EGGFCSSATCYYYFDC crystal 3.40A 25.60% FAB 11-APR-18 20180411 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IOMA - CLASS CLK31 FAB FROM AN HIV - 1 NAIVE DONOR IN COMPLEX WITH A GERMLINE - TARGETING GP120 ENGINEERED OUTER DOMAIN EOD - GT8 AT 2.6 A MOLECULE: GERMLINE - TARGETING HIV - 1 GP120 ENGINEERED OUTER DOMAIN EOD - GT8; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TGTSSDVGSNLVS 7 EGSKRPS 8 CSYAGSVV 5 GYYMH 17 WINPNSGGTNYAQKFQG 9 SLGRDWFDP crystal 2.60A 21.60% FAB 13-APR-18 20180413 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT OF RHESUS MACAQUE (MACACA MULATTA) IGG1. ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: MACACA MULATTA; ORGANISM_COMMON: RHESUS MACAQUE; ORGANISM_TAXID: 9544; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 22.30% FC 18-APR-18 20180418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT OF RHESUS MACAQUE (MACACA MULATTA) IGG2 ? ? IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MACACA MULATTA; ORGANISM_COMMON: RHESUS MACAQUE; ORGANISM_TAXID: 9544; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.95A 21.00% FC 18-APR-18 20180418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT OF RHESUS MACAQUE (MACACA MULATTA) IGG3 ? ? IGG3 MOL_ID: 1; ORGANISM_SCIENTIFIC: MACACA MULATTA; ORGANISM_TAXID: 9544; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.47A 25.30% FC 18-APR-18 20180418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT OF RHESUS MACAQUE (MACACA MULATTA) IGG4 ? ? IGG4 MOL_ID: 1; ORGANISM_SCIENTIFIC: MACACA MULATTA; ORGANISM_TAXID: 9544; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.25A 21.50% FC 18-APR-18 20180418 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A FC FRAGMENT OF HUMAN IGG3 ? ? IGG3 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK 293; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.39A 23.70% FC 19-APR-18 20180419 TRANSPORT PROTEIN HUMAN GABA - A RECEPTOR ALPHA1 - BETA2 - GAMMA2 SUBTYPE IN COMPLEX WITH GABA AND FLUMAZENIL, CONFORMATION B MOLECULE: GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA - 1,GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA - 1; SYNONYM: GABA (A) RECEPTOR SUBUNIT ALPHA - 1,GABA (A) RECEPTOR SUBUNIT ALPHA - 1; ENGINEERED: YES; KAPPA IGG2 MUS MUSCULUS 11 KASEYVGTYVS 7 GASNRYT 8 GQSYSYPT 5 DTYMY 17 RIDPANGDTKYDPKFQG 9 KGLRWAMDY ElectronMicroscopy N/A N/A FAB 22-APR-18 20180422 TRANSPORT PROTEIN HUMAN GABA - A RECEPTOR ALPHA1 - BETA2 - GAMMA2 SUBTYPE IN COMPLEX WITH GABA AND FLUMAZENIL, CONFORMATION A MOLECULE: GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA - 1,GAMMA - AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA - 1; SYNONYM: GABA (A) RECEPTOR SUBUNIT ALPHA - 1,GABA (A) RECEPTOR SUBUNIT ALPHA - 1; ENGINEERED: YES; KAPPA IGG2 MUS MUSCULUS 11 KASEYVGTYVS 7 GASNRYT 8 GQSYSYPT 5 DTYMY 17 RIDPANGDTKYDPKFQG 9 KGLRWAMDY ElectronMicroscopy N/A N/A FAB 22-APR-18 20180422 IMMUNE SYSTEM X - RAY STRUCTURE OF THE FAB FRAGMENT OF 15B8, A MURINE MONOCLONAL ANTIBODY SPECIFIC FOR THE HUMAN SEROTONIN TRANSPORTER ? ? ? MUS MUSCULUS 15 RASESVDNYGISFLN 7 AASNQGS 9 QQTKGVSWT 5 YSWMN 17 RIYPGDGDTKYSGKFKG 12 SAYGSEGFAMDY crystal 2.30A 19.70% FAB 29-APR-18 20180429 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF DEINOCOCCUS RADIODURANS MNTH, AN NRAMP - FAMILY TRANSITION METAL TRANSPORTER, IN THE INWARD - OPEN APO STATE MOLECULE: DIVALENT METAL CATION TRANSPORTER MNTH; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YVSQSSS 9 QQSNSWPRT 5 SYGVH 16 VIWSDGSTTYNSALKS 6 EPPYGY crystal 3.94A 27.50% FAB 30-APR-18 20180430 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB TA6 IN COMPLEX WITH A HIV - 1 GP120 V3 PEPTIDE FROM NY5 STRAIN MOLECULE: HIV - 1 GP120 V3 PEPTIDE FROM NY5 STRAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDELPKKYAY 7 EDSKRPS 11 FSTDSSGDLWV 5 NYAIH 17 WINGGDGNTKYSQKLQG 16 AYYYGSRGLVDDALDV crystal 2.60A 23.00% FAB 02-MAY-18 20180502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 311 - 11D IN COMPLEX WITH A HIV - 1 GP120 V3 PEPTIDE FROM MN STRAIN MOLECULE: HIV - 1 GP120 V3 PEPTIDE FROM MN STRAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDVLPKKYAY 7 EDNRRPS 11 SSTDSSGDHYV 5 TYAMH 17 WINGGNGDTRYSQKFRG 14 ESGDYYSEISGALD crystal 1.98A 17.60% FAB 02-MAY-18 20180502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - HIV - 1 V3 FAB 1334 IN COMPLEX WITH A HIV - 1 GP120 V3 PEPTIDE FROM MN STRAIN MOLECULE: HIV - 1 GP120 V3 PEPTIDE FROM MN STRAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDALPKEYAY 7 EDTRRPS 11 YSRDTSANQWV 5 KFAIH 17 WINGDDGKTEYSQKFQD 22 AMYPDTVTGNDNPAPPPFEGDY crystal 2.21A 21.50% FAB 02-MAY-18 20180502 RNA / IMMUNE SYSTEM STRUCTURAL BASIS FOR PROMISCUOUS BINDING AND ACTIVATION OF FLUOROGENIC DYES BY DIR2S RNA APTAMER MOLECULE: RNA (60 - MER); ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 9 QQSYSFPST 7 ISYSSIH 17 VASISPYSGSTYYADSV 15 ARQGYRRRSGRGFDY crystal 1.87A 22.00% FAB 02-MAY-18 20180502 RNA / IMMUNE SYSTEM STRUCTURAL BASIS FOR PROMISCUOUS BINDING AND ACTIVATION OF FLUOROGENIC DYES BY DIR2S RNA APTAMER MOLECULE: RNA (60 - MER); ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 9 QQSYSFPST 5 YSSIH 17 SISPYSGSTYYADSVKG 13 QGYRRRSGRGFDY crystal 2.03A 23.10% FAB 02-MAY-18 20180502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VHH R303 MOLECULE: NANOBODY VHH R303; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 TYCMG 17 RINVGGSSTWYADSVRD 14 HRFCNTWSLGTLNV crystal 1.30A 16.20% HC-dimer 02-MAY-18 20180502 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VHH R326 ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_STRAIN: BL21; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PET22B Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.76A 16.10% HC-dimer 03-MAY-18 20180503 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VHH R330 MOLECULE: NANOBODY VHH R303; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 3 TMG 17 DISWNGGSTYYADSVKG 9 DDLMIDRDY crystal 1.65A 18.70% HC-dimer 03-MAY-18 20180503 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VHH R303 IN COMPLEX WITH INLB - LRR MOLECULE: LISTERIA VIRULENCE FACTOR INLB; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 TYCMG 16 INVGGSSTWYADSVRD 14 HRFCNTWSLGTLNV crystal 1.55A 13.90% HC-dimer 03-MAY-18 20180503 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VHH R303 IN COMPLEX WITH INLB - LRR - IR MOLECULE: INTERNALIN B; ENGINEERED: YES; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 TYCMG 19 VARINVGGSSTWYADSVRD 14 HRFCNTWSLGTLNV crystal 1.51A 16.10% HC-dimer 03-MAY-18 20180503 IMMUNE SYSTEM APO FAB STRUCTURE OF MOUSE MONOCLONAL ANTIBODY 8B2 ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFY 9 FQDSHIPYT 5 SYVIH 17 YIYPYNDGTIYNEKFKG 8 ERDNYGVY crystal 1.90A 18.50% FAB 04-MAY-18 20180504 IMMUNE SYSTEM FAB / EPITOPE COMPLEX OF MOUSE MONOCLONAL ANTIBODY 8B2 TARGETING A NON - PHOSPHORYLATED TAU EPITOPE. MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? IGG MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFY 9 FQDSHIPYT 5 SYVIH 17 YIYPYNDGTIYNEKFKG 8 ERDNYGVY crystal 1.80A 18.10% FAB 04-MAY-18 20180504 IMMUNE SYSTEM FAB / EPITOPE COMPLEX OF HUMAN CHIMERIC MONOCLONAL ANTIBODY H4E6 TARGETING A PHOSPHORYLATED TAU EPITOPE. MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? ? HOMO SAPIENS 11 HASQNINVWLS 7 EASTLYT 9 QQGQSYPWT 5 DTSMH 17 RIAPANGNTKYDPKFQG 5 SGNYD crystal 3.00A 20.80% FAB 04-MAY-18 20180504 IMMUNE SYSTEM FAB / EPITOPE COMPLEX OF MOUSE MONOCLONAL ANTIBODY 6B2 TARGETING A NON - PHOSPHORYLATED TAU EPITOPE. MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHSPLT 5 EYTKH 17 SINPNNGDTYYNQKFTD 8 GDSAWFAY crystal 2.60A 19.10% FAB 04-MAY-18 20180504 VIRAL PROTEIN ECTODOMAIN OF FULL LENGTH, WILD TYPE HIV - 1 GLYCOPROTEIN CLONE PC64M18C043 IN COMPLEX WITH PGT151 FAB MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41 DOMAIN RESIDUES 508 - 859; ENGINEERED: YES; ? ? HOMO SAPIENS 16 KSSESLRQSNGKTSLY 7 EVSNRFS 9 MQSKDFPLT 5 KYPMY 17 AISGDAWHVVYSNSVQG 26 MFQESGPPRLDRWSGRNYYYYSGMDV ElectronMicroscopy N/A N/A FAB 08-MAY-18 20180508 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - TAU ANTIBODY CBTAU - 27.1 ? ? ? HOMO SAPIENS 17 KSSQSVFSRDNNKNYLA 7 WASSRES 9 QHYFNTPHN 5 DYWTA 17 IIYSGDSDTRYHPSVQG 13 LDARVDAGWQLDS crystal 1.90A 18.80% FAB 08-MAY-18 20180508 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN ANTI - TAU ANTIBODY CBTAU - 27.1 FAB IN COMPLEX WITH A HUMAN TAU PEPTIDE MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 17 KSSQSVFSRDNNKNYLA 7 WASSRES 9 QHYFNTPHN 5 DYWTA 17 IIYSGDSDTRYHPSVQG 13 LDARVDAGWQLDS crystal 2.00A 17.10% FAB 08-MAY-18 20180508 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE EPITOPE OF AN ANTI - MICA ANTIBODY MOLECULE: MHC CLASS I POLYPEPTIDE - RELATED SEQUENCE A; SYNONYM: MHC CLASS I POLYPEPTIDE - RELATED SEQUENCE A,ISOFORM CRA_C, MICA,STRESS INDUCIBLE CLASS I HOMOLOG,CDNA FLJ60820,HIGHLY SIMILAR TO HOMO SAPIENS MHC CLASS I POLYPEPTIDE - RELATED SEQUENCE A (MICA) ,MRNA; ENGINEERED: YES; ? ? MUS MUSCULUS 12 SASSSISSHYLH 7 RTSNLAS 9 QQGSSLPLT 5 SQNIY 17 YIEPYNVVPMYNPKFKG 8 SGSSNFDY crystal 1.30A 18.90% FAB 10-MAY-18 20180510 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE EPITOPE OF AN ANTI - MICA ANTIBODY MOLECULE: MHC CLASS I POLYPEPTIDE - RELATED SEQUENCE A; SYNONYM: MHC CLASS I POLYPEPTIDE - RELATED SEQUENCE A,ISOFORM CRA_C, MICA,STRESS INDUCIBLE CLASS I HOMOLOG,CDNA FLJ60820,HIGHLY SIMILAR TO HOMO SAPIENS MHC CLASS I POLYPEPTIDE - RELATED SEQUENCE A (MICA) ,MRNA; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHSYLA 7 YAETLAD 9 QQFWTTPYT 5 NYLIE 17 AINPGSGATNYNEKFKD 8 FLGNYFDN crystal 1.90A 21.00% FAB 10-MAY-18 20180510 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE EPITOPE OF AN ANTI - MICA ANTIBODY MOLECULE: MHC CLASS I CHAIN - RELATED PROTEIN A; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 16 RSSQHIVHSNENTYLE 7 KVSNRFS 9 FQGSHVPWT 5 DNYIS 17 WIYAGTGGSSYNQKFRD 13 HDYYGTSGAWFAY crystal 2.05A 22.60% FAB 10-MAY-18 20180510 IMMUNE SYSTEM ANTI - PHOSPHOTYROSINE ANTIBODY PY20 - 4D5 FAB COMPLEXED WITH SULFATE SULFATE ? ? SYNTHETIC CONSTRUCT 11 SASQGISNYLN 7 YTSSLHS 9 QQYSKVPWT 5 EYTMH 14 GINPNSGGTRDNQR 15 RGPYGNYYNSYYFDY crystal 3.20A 23.10% FAB 13-MAY-18 20180513 IMMUNE SYSTEM ANTI - PHOSPHOTYROSINE ANTIBODY 4G10 - 4D5 FAB COMPLEXED WITH SULFATE SULFATE ? ? SYNTHETIC CONSTRUCT 12 RASSSVSSSYLH 7 STSNLAS 8 QQYSGYRT 5 ENTVH 17 GINPYYGGSIFSPKFKG 9 RAGAYYFDY crystal 2.30A 20.20% FAB 13-MAY-18 20180513 IMMUNE SYSTEM ANTI - PHOSPHOTYROSINE ANTIBODY 4G10 - 4D5 FAB COMPLEXED WITH SULFATE MOLECULE: LEU - PTR; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASSSVSSSYLH 7 STSNLAS 8 QQYSGYRT 5 ENTVH 17 GINPYYGGSIFSPKFKG 9 RAGAYYFDY crystal 2.30A 20.40% FAB 13-MAY-18 20180513 IMMUNE SYSTEM IMPROVED ANTI - PHOSPHOTYROSINE ANTIBODY 4G10 - S5 - 4D5 FAB COMPLEXED WITH PHOSPHOTYROSINE PEPTIDE MOLECULE: LEU - PTR - LEU; ENGINEERED: YES ? ? SYNTHETIC CONSTRUCT 12 RASSSVSSSYLH 7 STSNLAS 11 QQYSRRTSYRT 5 ENTVH 17 GINPYYGGSIFSPKFKG 9 RAGAYYFDY crystal 2.60A 17.90% FAB 13-MAY-18 20180513 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - ZIKA ANTIBODY Z021 BOUND TO ZIKA VIRUS ENVELOPE PROTEIN DIII MOLECULE: ZIKA VIRUS ENVELOPE PROTEIN DIII; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSNYFA 7 DTSKRAT 11 QERNNWPLTWT 5 TYYWS 16 CFYYSVDNHFNPSLES 10 NQPGGRAFDY crystal 2.48A 18.40% FAB 14-MAY-18 20180514 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - ZIKA ANTIBODY Z021 BOUND TO DENV - 1 ENVELOPE PROTEIN DIII MOLECULE: DENGUE 1 ENVELOPE DIII DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSNYFA 7 DTSKRAT 11 QERNNWPLTWT 5 TYYWS 16 CFYYSVDNHFNPSLES 10 NQPGGRAFDY crystal 2.07A 18.60% FAB 14-MAY-18 20180514 IMMUNE SYSTEM ANTIGEN BINDING FRAGMENT OF THE PAN - EBOLAVIRUS MONOCLONAL ANTIBODY 6D6 ? ? ? MUS MUSCULUS 11 KASQDVSVAVA 7 SASYRIT 10 QQHYSTPPWT 5 SYWMH 17 EINPRNGRTDFSEKFKS 9 WGYYGSSDY crystal 1.96A 19.20% FAB 16-MAY-18 20180516 VIRAL PROTEIN HIV ENV BG505 SOSIP WITH POLYCLONAL FABS FROM IMMUNIZED RABBIT #3417 POST - BOOST#1 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41 DOMAIN RESIDUES 509 - 661; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; ? ? ORYCTOLAGUS CUNICULUS 11 QASQSIRSYLA 7 EASKLAS 15 QRNYDSYSGAYYPNG 6 SDYYMC 17 CIWTANSISYYARWAKG 9 GGSGDGQSL ElectronMicroscopy N/A N/A FAB 23-MAY-18 20180523 PROTEIN FIBRIL NFVFGT SEGMENT FROM HUMAN IMMUNOGLOBULIN LIGHT - CHAIN VARIABLE DOMAIN, RESIDUES 98 - 103, ASSEMBLED AS AN AMYLOID FIBRIL ? ? ? MOL_ID: 1; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.00A 10.50% HC-dimer 23-MAY-18 20180523 PROTEIN FIBRIL YTFGQ SEGMENT FROM HUMAN IMMUNOGLOBULIN LIGHT - CHAIN VARIABLE DOMAIN, RESIDUES 96 - 100, ASSEMBLED AS AN AMYLOID FIBRIL ? KAPPA ? MOL_ID: 1; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 0.90A 9.90% ? 24-MAY-18 20180524 PROTEIN FIBRIL ASLTVS SEGMENT FROM HUMAN IMMUNOGLOBULIN LIGHT - CHAIN VARIABLE DOMAIN, RESIDUES 73 - 78, ASSEMBLED AS AN AMYLOID FIBRIL ? LAMBDA ? MOL_ID: 1; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.30A 18.60% HC-dimer 24-MAY-18 20180524 MEMBRANE PROTEIN INTEGRIN ALPHA - V BETA - 8 IN COMPLEX WITH THE FABS 8B8 AND 68 MOLECULE: INTEGRIN BETA - 8; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYIH 7 DTSKLAS 9 HQWTSNPAT 6 SSYYWN 16 YISYDGSNSYNPSLKN 8 EDYDSFDY ElectronMicroscopy N/A N/A FAB 25-MAY-18 20180525 SIGNALING PROTEIN HUMAN GIPR ECD AND FAB COMPLEX MOLECULE: GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; FRAGMENT: RESIDUES 22 - 138; SYNONYM: GIP - R,GLUCOSE - DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSNLA 7 GAATRAT 9 QQYNNWPLT 5 NYGMH 17 AIWFDASDKYYADAVKG 11 DQAIFGVVPDY crystal 1.95A 20.10% FAB 29-MAY-18 20180529 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN INFLUENZA A HEMAGGLUTININ ANTIBODY FAB VARIANT CH67:1203D4 CHIMERA ? ? ? HOMO SAPIENS 11 GGNNIGRKRVD 0 11 QVWDSDSDHVV 5 DNYIH 17 WIHPNSGATKYAQKFEG 17 AGLHPTTTEYYYYGMDV crystal 3.81A 23.50% FAB 31-MAY-18 20180531 IMMUNE SYSTEM CRYSTAL STRUCTURES OF AN INFLUENZA A HEMAGGLUTININ ANTIBODY FAB CH65:7969D2 ? ? ? HOMO SAPIENS 11 GGNDIGRKSVH 7 YDSDRPS 11 QVWDSSSDHVI 5 DYHIN 17 WIHPNSGDTNYAQKFQG 17 AGLHPTTTDYYYYGMDV crystal 2.00A 17.90% FAB 31-MAY-18 20180531 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN INFLUENZA A HEMAGGLUTININ ANTIBODY FAB CH65:1203D4 CHIMERA ? ? ? HOMO SAPIENS 11 GGNDIGRKSVH 7 YDSDRPS 11 QVWDSSSDHVI 5 DYHIN 17 WIHPNSGDTNYAQKFQG 17 AGLHPTTTEYYYYGMDV crystal 2.20A 19.20% FAB 31-MAY-18 20180531 MEMBRANE PROTEIN STRUCTURE OF NANOBODY - STABILIZED ANGIOTENSIN II TYPE 1 RECEPTOR BOUND TO S1I8 MOLECULE: TYPE - 1 ANGIOTENSIN II RECEPTOR,SOLUBLE CYTOCHROME B562 BRIL FUSION PROTEIN; SYNONYM: AT1AR,AT1BR,ANGIOTENSIN II TYPE - 1 RECEPTOR,AT1,CYTOCHROME B - 562,AT1AR,AT1BR,ANGIOTENSIN II TYPE - 1 RECEPTOR,AT1; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 VDIMG 16 SITDGGSTDYADSVKG 18 VAYPDIPTYFDYDSDNFY crystal 2.90A 30.80% HC-dimer 08-JUN-18 20180608 IMMUNE SYSTEM STRUCTURE OF THE 6078 ANTIBODY FAB FRAGMENT BOUND TO A STAPHYLOCOCCUS AUREUS WALL TECHOIC ACID ANALOG ? ? ? HOMO SAPIENS 11 RASQTISGWLA 7 KASTLES 9 QQYKSYSFN 5 SYDIN 17 WMNANSGNTGYAQKFQG 15 SSILVRGALGRYFDL crystal 1.70A 18.90% FAB 26-JUN-18 20180626 IMMUNE SYSTEM STRUCTURE OF THE 4497 ANTIBODY FAB FRAGMENT BOUND TO A STAPHYLOCOCCUS AUREUS WALL TECHOIC ACID ANALOG ? ? ? HOMO SAPIENS 17 KSSQSIFRTSRNKNLLN 7 WASTRKS 9 QQYFSPPYT 5 SFWMH 17 FTNNEGTTTAYADSVRG 7 GDGGLDD crystal 1.92A 20.80% FAB 26-JUN-18 20180626 IMMUNE SYSTEM STRUCTURE OF THE APO 4497 ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 17 KSSQSIFRTSRNKNLLN 7 WASTRKS 9 QQYFSPPYT 5 SFWMH 17 FTNNEGTTTAYADSVRG 7 GDGGLDD crystal 2.27A 18.60% FAB 26-JUN-18 20180626 IMMUNE SYSTEM STRUCTURE OF THE 4462 ANTIBODY FAB FRAGMENT BOUND TO A STAPHYLOCOCCUS AUREUS WALL TECHOIC ACID ANALOG ? ? ? HOMO SAPIENS 11 RASQSVRTNVA 7 GASTRAS 9 LQYNTWPRT 5 TNDMS 17 TIIGIDDTTHYADSVRG 7 NSGIYSF crystal 2.39A 20.60% FAB 26-JUN-18 20180626 IMMUNE SYSTEM STRUCTURE OF VHH R419 ISOLATED FROM A PRE - IMMUNE PHAGE DISPLAY LIBRARY ? ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 TYAMG 19 VAAINWSGGNTHYADSVKG 9 PKGHTGDHY crystal 1.50A 17.70% HC-dimer 02-JUL-18 20180702 VIRAL PROTEIN EBOLA VIRUS MAKONA VARIANT GP (MUCIN - DELETED) IN COMPLEX WITH PAN - EBOLAVIRUS HUMAN ANTIBODY ADI - 15878 FAB MOLECULE: EBOLA VIRUS MAKONA GP1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 DASSLES 8 QQYYSSPT 5 SYAMS 17 AISGLGGSTYYADSVKG 13 DHRVWAAGYHFDY ElectronMicroscopy N/A N/A FAB 05-JUL-18 20180705 VIRAL PROTEIN BUNDIBUGYO VIRUS GP (MUCIN - DELETED) IN COMPLEX WITH PAN - EBOLAVIRUS HUMAN ANTIBODY ADI - 15878 FAB MOLECULE: BUNDIBUGYO VIRUS GP1; SYNONYM: SPIKE GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 DASSLES 8 QQYYSSPT 5 SYAMS 17 AISGLGGSTYYADSVKG 13 DHRVWAAGYHFDY ElectronMicroscopy N/A N/A FAB 05-JUL-18 20180705 IMMUNE SYSTEM PAN - EBOLAVIRUS HUMAN ANTIBODY ADI - 15878 FAB ? ? ? HOMO SAPIENS 11 RASQSISSWLA 7 DASSLES 8 QQYYSSPI 5 SYAMS 17 AISGLGGSTYYADSVKG 13 DHRVWAAGYHFDY crystal 2.10A 22.60% FAB 05-JUL-18 20180705 NUCLEAR PROTEIN CRYO - EM STRUCTURE OF NUCLEOSOME IN COMPLEX WITH A SINGLE CHAIN ANTIBODY FRAGMENT MOLECULE: HISTONE H4; ENGINEERED: YES; ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 05-JUL-18 20180705 TRANSPORT PROTEIN / IMMUNE SYSTEM WILD TYPE HUMAN SEROTONIN TRANSPORTER IN COMPLEX WITH 15B8 FAB BOUND TO IBOGAINE IN OCCLUDED CONFORMATION MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; FRAGMENT: UNP RESIDUES 79 - 615; SYNONYM: SERT, 5HT TRANSPORTER, 5HTT, SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFLN 7 AASNQGS 9 QQTKGVSWT 5 YSWMN 17 RIYPGDGDTKYSGKFKG 12 SAYGSEGFAMDY ElectronMicroscopy N/A N/A FAB 05-JUL-18 20180705 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYO - EM STRUCTURE OF THE TS2 - INACTIVE HUMAN SEROTONIN TRANSPORTER IN COMPLEX WITH PAROXETINE AND 15B8 FAB AND 8B6 SCFV MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; SYNONYM: SERT,5HT TRANSPORTER,5HTT,SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFLN 7 AASNQGS 9 QQTKGVSWT 5 YSWMN 17 RIYPGDGDTKYSGKFKG 12 SAYGSEGFAMDY ElectronMicroscopy N/A N/A FV 05-JUL-18 20180705 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYO - EM STRUCTURE OF THE TS2 - ACTIVE HUMAN SEROTONIN TRANSPORTER IN COMPLEX WITH 15B8 FAB AND 8B6 SCFV BOUND TO IBOGAINE MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; FRAGMENT: UNP RESIDUES 79 - 615; SYNONYM: SERT, 5HT TRANSPORTER, 5HTT, SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFLN 7 AASNQGS 9 QQTKGVSWT 5 YSWMN 17 RIYPGDGDTKYSGKFKG 12 SAYGSEGFAMDY ElectronMicroscopy N/A N/A FV 05-JUL-18 20180705 TRANSPORT PROTEIN / IMMUNE SYSTEM CRYO - EM STRUCTURE OF THE WILD - TYPE HUMAN SEROTONIN TRANSPORTER IN COMPLEX WITH IBOGAINE AND 15B8 FAB IN THE INWARD CONFORMATION MOLECULE: SODIUM - DEPENDENT SEROTONIN TRANSPORTER; FRAGMENT: UNP RESIDUES 79 - 615; SYNONYM: SERT, 5HT TRANSPORTER, 5HTT, SOLUTE CARRIER FAMILY 6 MEMBER 4; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFLN 7 AASNQGS 9 QQTKGVSWT 5 YSWMN 17 RIYPGDGDTKYSGKFKG 12 SAYGSEGFAMDY ElectronMicroscopy N/A N/A FAB 05-JUL-18 20180705 NUCLEAR PROTEIN CRYO - EM STRUCTURE OF THE CENP - A NUCLEOSOME (W601) IN COMPLEX WITH A SINGLE CHAIN ANTIBODY FRAGMENT MOLECULE: HISTONE H4; ENGINEERED: YES; ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 06-JUL-18 20180706 NUCLEAR PROTEIN CRYO - EM STRUCTURE OF THE CENTROMERIC NUCLEOSOME (NATIVE ALPHA SATELLITE DNA) IN COMPLEX WITH A SINGLE CHAIN ANTIBODY FRAGMENT MOLECULE: HISTONE H4; ENGINEERED: YES; ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 06-JUL-18 20180706 MEMBRANE PROTEIN STRUCTURE OF ATTPC1 (DDE) RECONSTITUTED IN SAPOSIN A WITH CAT06 FAB MOLECULE: TWO PORE CALCIUM CHANNEL PROTEIN 1; SYNONYM: CALCIUM CHANNEL PROTEIN 1,ATCCH1,FATTY ACID OXYGENATION UP - REGULATED PROTEIN 2,VOLTAGE - DEPENDENT CALCIUM CHANNEL PROTEIN TPC1, ATTPC1; ENGINEERED: YES; ? ? HOMO SAPIENS 9 RASVSSAVA 7 SASSLYS 12 QQSSSSLITFGQ 5 SYSIH 17 SISSYYSSTSYADSVKG 15 SYWYWRTSTLGGIDY ElectronMicroscopy N/A N/A FAB 10-JUL-18 20180710 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF S9 - 3 - 37 BOUND TO H5 INFLUENZA HEMAGGLUTININ MOLECULE: HEMAGGLUTININ HA2; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLVHSDGNTYLS 7 KISKRFS 9 TQASQFPRT 5 SYGFS 17 WISAYDAKTKFAEKFQD 21 EFRTQIVLGYFDWLEGNAFDM crystal 2.90A 20.70% ? 14-JUL-18 20180714 SIGNALING PROTEIN CRYO - EM STRUCTURE OF THE ACTIVE, GS - PROTEIN COMPLEXED, HUMAN CGRP RECEPTOR MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 16-JUL-18 20180716 VIRAL PROTEIN / IMMUNE SYSTEM HUMAN ANTIBODY S5V2 - 29 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ A / TEXAS / 50 / 2012 (H3N2) MOLECULE: HEMAGGLUTININ; FRAGMENT: HEAD DOMAIN (UNP RESIDUES 53 - 335); ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGASLN 7 AASNLQS 5 QQQGT 7 SNIYYWS 16 YFYHSGSSNYNPSLKS 20 GGVENLMLVAVIQEMWYFDL crystal 2.25A 20.40% ? 18-JUL-18 20180718 IMMUNE SYSTEM ANTI - PCSK9 FAB 6E2 BOUND TO THE N - TERMINAL PEPTIDE FROM PCSK9, UNMODIFIED MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; FRAGMENT: UNP RESIDUES 32 - 53; SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1, NARC - 1, PROPROTEIN CONVERTASE 9, PC9, SUBTILISIN / KEXIN - LIKE PROTEASE PC9; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPFT 5 KYWMN 18 QIRLKSDNYATYAESVKG 5 EIFVN crystal 2.24A 21.40% FAB 18-JUL-18 20180718 IMMUNE SYSTEM ANTI - PCSK9 FAB 6E2 BOUND TO THE MODIFIED N - TERMINAL PEPTIDE FROM PCSK9 MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; FRAGMENT: UNP RESIDUES 32 - 53; SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1, NARC - 1, PROPROTEIN CONVERTASE 9, PC9, SUBTILISIN / KEXIN - LIKE PROTEASE PC9; ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPFT 5 KYWMN 18 QIRLKSDNYATYAESVKG 5 EIFVN crystal 2.20A 19.70% FAB 18-JUL-18 20180718 VIRAL PROTEIN / IMMUNE SYSTEM HUMAN ANTIBODY H2214 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ A / AICHI / 2 / 1968 (X - 31) (H3N2) MOLECULE: HEMAGGLUTININ; FRAGMENT: HEAD DOMAIN (UNP RESIDUES 53 - 335); ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASESISSNLA 7 GASTRAT 10 QQYNNRLPYT 5 HYAMT 17 SSSGSGRSTYYTDSVKG 20 SSNYYGSGSYSPDDYYHMDV crystal 2.00A 18.90% ? 19-JUL-18 20180719 VIRAL PROTEIN BACKBONE MODEL BASED ON CRYO - EM MAP AT 8.5 A OF DOMAIN - SWAPPED, GLYCAN - REACTIVE, NEUTRALIZING ANTIBODY 2G12 BOUND TO HIV - 1 ENV BG505 DS - SOSIP, WHICH WAS ALSO BOUND TO CD4 - BINDING SITE ANTIBODY VRC03 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 10 KASQGGNAMT 7 DTSRRAS 5 QQFEF 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA ElectronMicroscopy N/A N/A ? 21-JUL-18 20180721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MALARIA TRANSMISSION - BLOCKING ANTIGEN PFS48 / 45 6C IN COMPLEX WITH ANTIBODY 85RF45.1 MOLECULE: PF48 / 45; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVS 7 RDDQRPD 11 FCHSYSTGMYI 5 NYWMS 17 SISNIGGTIYYPDSVKG 10 DLRMSDYFDY crystal 2.70A 24.70% FAB 23-JUL-18 20180723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MALARIA TRANSMISSION - BLOCKING ANTIGEN PFS48 / 45 6C IN COMPLEX WITH ANTIBODY TB31F MOLECULE: PF48 / 45; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSTGNIGSNYVS 7 RDDQRPS 11 YCHSYSTGMYI 5 NYWMS 17 SISNIGGTIYYPDSVKG 10 DLRMSDYFDY crystal 2.60A 20.40% FAB 23-JUL-18 20180723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MALARIA TRANSMISSION - BLOCKING ANTIGEN PFS48 / 45 6C IN COMPLEX WITH ANTIBODY 85RF45.1 WITH ANTIBODY 85RF45.1 ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVS 7 RDDQRPD 11 FCHSYSTGMYI 5 NYWMS 17 SISNIGGTIYYPDSVKG 10 DLRMSDYFDY crystal 3.15A 24.80% FAB 23-JUL-18 20180723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF MALARIA TRANSMISSION - BLOCKING ANTIGEN PFS48 / 45 6C IN COMPLEX WITH ANTIBODY 85RF45.1 WITH ANTIBODY 85RF45.1 ? ? HOMO SAPIENS 13 TRSTGNIGSNYVS 7 RDDQRPS 11 YCHSYSTGMYI 5 NYWMS 17 SISNIGGTIYYPDSVKG 10 DLRMSDYFDY crystal 1.50A 17.50% FAB 23-JUL-18 20180723 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV - 2 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 7 WVRQAPG 19 AGYNPGLKSRLSITQDVSL 26 DCGAARRTCCSRYDFCGYSMYARADW crystal 2.90A 22.30% ? 01-AUG-18 20180801 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV - 3 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTGGNAGYNPGLKS 26 VHQRTKTTKSCPDGYSDGYRCGWRRS crystal 2.00A 21.90% ? 01-AUG-18 20180801 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV - 4 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTGGSAGYNPGLKS 26 VHQKTQLTKSCPDGYSDCYGCGAYCP crystal 2.50A 20.40% ? 01-AUG-18 20180801 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV - 5 MOLECULE: IGL@ PROTEIN; ENGINEERED: YES ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTGGNAGYNPGLKS 26 VHQKTRKTFSCPEGYSVGYSCGCNCH crystal 2.19A 20.70% ? 01-AUG-18 20180801 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV - 6 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 2 VG 16 SIDTGGNAGYNPGLKS 26 VHQKTTRNCPAGYSVHYDCSFGDGCT crystal 3.40A 25.70% ? 01-AUG-18 20180801 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV - 7 ? ? ? BOS TAURUS 13 SGSSSNVGNGYVS 7 GDTSRAS 11 ASAEDSSSNAV 5 DKAVG 16 SIDTGGNAGYNPGLKS 26 VHQKTTKQKSCPEGWSFADRCYYGSG crystal 2.30A 21.60% ? 01-AUG-18 20180801 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF BDBV GPCL IN COMPLEX WITH THE PAN - EBOLAVIRUS MAB ADI - 15878 MOLECULE: GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 DASSLES 8 QQYYSSPT 5 SYAMS 17 AISGLGGSTYYADSVKG 13 DHRVWAAGYHFDY crystal 4.75A 29.60% FAB 02-AUG-18 20180802 VIRAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF EBOV GPCL IN COMPLEX WITH THE PAN - EBOLAVIRUS MAB ADI - 15878 MOLECULE: ENVELOPE GLYCOPROTEIN; SYNONYM: GP1,2,GP; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 DASSLES 8 QQYYSSPT 5 SYAMS 17 AISGLGGSTYYADSVKG 13 DHRVWAAGYHFDY crystal 4.25A 28.30% FAB 02-AUG-18 20180802 IMMUNE SYSTEM GLYCOSYLATED FCGR3B / CD16B IN COMPLEX WITH AFUCOSYLATED IGG1 FC ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293F; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGR3B, CD16B, FCG3, FCGR3, IGFR3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S LEC1(-/-) 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.22A 21.50% FC 03-AUG-18 20180803 VIRAL PROTEIN STRUCTURAL BASIS FOR BROAD NEUTRALIZATION OF EBOLAVIRUSES BY AN ANTIBODY TARGETING THE GLYCOPROTEIN FUSION LOOP MOLECULE: ENVELOPE GLYCOPROTEIN; SYNONYM: GP1,2,GP; ENGINEERED: YES ? ? MACACA FASCICULARIS 11 RASQSISNNLA 7 AASNLAS 9 QQHNTLPLT 6 GYYHWN 17 NIDGNSASTNYNPSLKT 19 DPGFTIFGVVITSWSGLDS crystal 3.72A 26.00% ? 03-AUG-18 20180803 IMMUNE SYSTEM B41 SOSIP.664 IN COMPLEX WITH SOLUBLE CD4 (D1 - D2) , THE CO - RECEPTOR MIMICKING ANTIBODY 21C AND THE BROADLY NEUTRALIZING ANTIBODY 8ANC195 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGKNYVS 7 DDTQRPS 12 GTWDSSLSTGQL 5 GLSIH 17 GFGPEENEIIYAQKFQG 16 GGNYYNLWTGYYPLAY ElectronMicroscopy N/A N/A FAB 11-AUG-18 20180811 IMMUNE SYSTEM COMPLEMENT COMPONENT C3B IN COMPLEX WITH A NANOBODY MOLECULE: COMPLEMENT C3; SYNONYM: C3 AND PZP - LIKE ALPHA - 2 - MACROGLOBULIN DOMAIN - CONTAINING PROTEIN 1; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNAMG 17 TINRSGGRTYYADSVKG 14 GTGWSPQTDNEYNY crystal 2.65A 0.00% HC-dimer 13-SEP-17 20170913 IMMUNE SYSTEM SCFV ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN DRUG DISCOVERY ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.54A 27.60% scFv 15-SEP-17 20170915 IMMUNE SYSTEM SCFV ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN DRUG DISCOVERY ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.19A 21.40% scFv 15-SEP-17 20170915 IMMUNE SYSTEM SCFV ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN DRUG DISCOVERY ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.20A 20.90% scFv 15-SEP-17 20170915 IMMUNE SYSTEM SCFV ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN DRUG DISCOVERY ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.25A 23.10% scFv 15-SEP-17 20170915 CELL ADHESION CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 4 MOLECULE: CD81 ANTIGEN; SYNONYM: 26 KDA CELL SURFACE PROTEIN TAPA - 1,TARGET OF THE ANTIPROLIFERATIVE ANTIBODY 1,TETRASPANIN - 28,TSPAN - 28; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASKSVSTSIYSYMH 7 YASYLES 15 EHSREFPFTFGTGTK 7 TSIYSYM 13 KLLIKYASYLESG 26 HSREFPFTFGTGTKLEIKQVQLQQSG crystal 2.82A 22.90% scFv 21-SEP-17 20170921 CELL ADHESION CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 5 MOLECULE: CD81 ANTIGEN; SYNONYM: 26 KDA CELL SURFACE PROTEIN TAPA - 1,TARGET OF THE ANTIPROLIFERATIVE ANTIBODY 1,TETRASPANIN - 28,TSPAN - 28; ENGINEERED: YES; ? ? MUS MUSCULUS 17 AASGFTFRSYIMSWVRQ 7 GGNTYYP 15 YYCASLTAVGDYWGQ 5 SYIMS 17 TISGGGGNTYYPDSVKG 26 LTAVGDYWGQGTSVTVSSGGDVVMTQ crystal 2.15A 21.90% scFv 22-SEP-17 20170922 CELL ADHESION CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 10 MOLECULE: CD81 ANTIGEN; FRAGMENT: UNP RESIDUES 112 - 201; SYNONYM: 26 KDA CELL SURFACE PROTEIN TAPA - 1,TARGET OF THE ANTIPROLIFERATIVE ANTIBODY 1,TETRASPANIN - 28,TSPAN - 28; ENGINEERED: YES; ? ? MUS MUSCULUS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.65A 18.20% scFv 25-SEP-17 20170925 IMMUNE SYSTEM FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY ? ? ? HOMO SAPIENS 11 RASQDINNYLN 7 YTSRLHS 9 QQGSTLPFT 5 RYWMS 17 EVNPDSTSINYTPSLKD 15 PNYYGSRYHYYAMDY crystal 1.78A 19.10% FAB 28-SEP-17 20170928 IMMUNE SYSTEM FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY ? ? ? HOMO SAPIENS 11 RASQDINNYLN 7 YTSRLHS 9 QQGSTLPFT 5 RYWMS 17 EVNPDSTSINYTPSLKD 15 PNYYGSRYHYYAMDY crystal 1.90A 18.40% FAB 29-SEP-17 20170929 IMMUNE SYSTEM FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY ? ? ? HOMO SAPIENS 11 RASQDINNYLN 7 YTSRLHS 9 QQGSTLPFT 5 RYWMS 17 EVNPDSTSINYTPSLKD 15 PNYYGSRYHYYAMDY crystal 1.90A 20.50% FAB 29-SEP-17 20170929 IMMUNE SYSTEM FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY ? ? ? HOMO SAPIENS 11 RASQDINNYLN 7 YTSRLHS 9 QQGSTLPFT 5 RYWMS 17 EVNPDSTSINYTPSLKD 15 PNYYGSRYHYYAMDY crystal 2.30A 16.80% FAB 02-OCT-17 20171002 VIRAL PROTEIN CRYO - EM RECONSTRUCTION OF A COMPLEX OF A BINDING PROTEIN AND HUMAN ADENOVIRUS C5 HEXON MOLECULE: HEXON PROTEIN; SYNONYM: CP - H,PROTEIN II; ? ? MUS MUSCULUS 17 GDRVTITCKASQSVTND 7 KAPKLLI 15 EDFATYFCHQDYSSP 7 TCKASQS 16 APKLLIYQASTRYTGV 26 DYSSPLTFGQGTKVEIKRQVQLVQSG ElectronMicroscopy N/A N/A scFv 12-OCT-17 20171012 TRANSFERASE STRUCTURE OF PINK1 BOUND TO UBIQUITIN MOLECULE: SERINE / THREONINE - PROTEIN KINASE PINK1, PUTATIVE; EC: 2.7.11.1; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TFDLA 14 GLRRGGSTFYADSV 16 SITGYGLVDSASHYTI crystal 3.10A 20.50% HC-dimer 13-OCT-17 20171013 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY AGAINST SCHIZOPHYLLAN MOLECULE: HEAVY CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSSNPPT 5 SYWMH 17 YINPSTGYTEYNQKFKD 8 LWPLGTDY crystal 3.04A 18.80% FAB 01-NOV-17 20171101 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY AGAINST SCHIZOPHYLLAN IN COMPLEX WITH LAMINARIHEXAOSE MOLECULE: HEAVY CHAIN; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVSYMH 7 DTSKLAS 9 QQWSSNPPT 5 SYWMH 17 YINPSTGYTEYNQKFKD 8 LWPLGTDY crystal 2.40A 19.50% FAB 01-NOV-17 20171101 VIRAL PROTEIN CRYSTAL STRUCTURE OF GII.4 UNSW 2012 P DOMAIN IN COMPLEX WITH FAB 10E9 MOLECULE: VP1; ENGINEERED: YES; ? ? MUS MUSCULUS 10 SASSSVDYMH 7 DTYKLAS 9 QQWSSNPLT 5 TYWIQ 17 ETLPGSGSTNYNEKFKG 7 IGRSNDY crystal 2.78A 18.80% FAB 03-NOV-17 20171103 PROTEIN TRANSPORT N - TERMINAL PART (RESIDUES 30 - 212) OF PORM WITH THE LLAMA NAOBODY NB01 MOLECULE: T9SS COMPONENT CYTOPLASMIC MEMBRANE PROTEIN PORM; ENGINEERED: YES; OTHER_DETAILS: RESIDUE GLU145 IS MUTATED TO ASP; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYSMG 17 AISRSDNSTYYADSVKG 17 TPYGSRYYLRELREYDY crystal 2.40A 21.40% HC-dimer 10-NOV-17 20171110 PROTEIN TRANSPORT C - TERMINAL PART (RESIDUES 315 - 516) OF PORM WITH THE LLAMA NAOBODY NB130 MOLECULE: T9SS COMPONENT CYTOPLASMIC MEMBRANE PROTEIN PORM; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYVMG 17 AISWSGGSIHYADSVKG 21 GFAGYGSFTSRSARDSDKYDY crystal 2.10A 18.20% HC-dimer 10-NOV-17 20171110 IMMUNE SYSTEM STRUCTURE OF THE 8D6 (ANTI - IGE) FAB ? ? ? HOMO SAPIENS 15 KASQSVDYDGDTYMN 7 AASNLDS 9 QQTNEDPWT 2 MH 17 YINPTTGHTEYNQKFKD 10 QEYRHSWFAY crystal 2.40A 18.30% FAB 13-NOV-17 20171113 IMMUNE SYSTEM STRUCTURE OF EXTENDED IGE - FC IN COMPLEX WITH TWO ANTI - IGE FABS MOLECULE: IMMUNOGLOBULIN HEAVY CONSTANT EPSILON; SYNONYM: IG EPSILON CHAIN C REGION,IG EPSILON CHAIN C REGION ND; ENGINEERED: YES; OTHER_DETAILS: FC REGION OF IMMUNOGLOBULIN E; ? IGE HOMO SAPIENS 15 KASQSVDYDGDTYMN 7 AASNLDS 9 QQTNEDPWT 5 GYWMH 17 YINPTTGHTEYNQKFKD 10 QEYRHSWFAY crystal 3.70A 25.00% FAB 13-NOV-17 20171113 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A LLAMA VHH ANTIBODY BCD090 - M2 AGAINST HUMAN ERBB3 IN SPACE GROUP C2 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SMYTMG 18 VAANRGRGLSPDIADSVN 19 ADLQYGSSWPQRSSAEYDY crystal 1.60A 18.50% HC-dimer 16-NOV-17 20171116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A LLAMA VHH ANTIBODY BCD090 - M2 AGAINST HUMAN ERBB3 IN SPACE GROUP P1 WITH CADMIUM IONS ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 6 SMYTMG 18 VAANRGRGLSPDIADSVN 19 ADLQYGSSWPQRSSAEYDY crystal 1.90A 17.80% HC-dimer 19-NOV-17 20171119 TRANSPORT PROTEIN BACTERIAL ASC TRANSPORTER CRYSTAL STRUCTURE IN OPEN TO IN CONFORMATION MOLECULE: PUTATIVE AMINO ACID / POLYAMINE TRANSPORT PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SRAMG 17 TISWSGSYTEYADSVKG 15 KNGGAASNYPNDYVY crystal 2.92A 24.00% HC-dimer 24-NOV-17 20171124 TRANSPORT PROTEIN BACTERIAL ASC TRANSPORTER CRYSTAL STRUCTURE IN OPEN TO IN CONFORMATION MOLECULE: PUTATIVE AMINO ACID / POLYAMINE TRANSPORT PROTEIN; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SRAMG 17 TISWSGSYTEYADSVKG 15 KNGGAASNYPNDYVY crystal 3.40A 23.20% HC-dimer 27-NOV-17 20171127 IMMUNE SYSTEM STRUCTURE OF A FC MUTATNT ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 22.10% FC 27-NOV-17 20171127 HYDROLASE COMPLETE PCSK9 C - TER DOMAIN IN COMPLEX WITH VHH P.140 MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; FRAGMENT: PCSK9 DOMAIN; SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1,NARC - 1,PROPROTEIN CONVERTASE 9,PC9,SUBTILISIN / KEXIN - LIKE PROTEASE PC9; EC: 3.4.21. -; ENGINEERED: YES; OTHER_DETAILS: NATURALLY CLEAVED C - TER PCSK9 DOMAIN; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 AYAMG 17 TIRDSDASIYYTDSVKG 18 RQYYSGRVYSTFREEYDY crystal 2.20A 19.80% HC-dimer 01-DEC-17 20171201 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN FAB FRAGMENT IN COMPLEX WITH A PEPTIDE FROM BACILLUS SUBTILIS RNASE Y MOLECULE: RIBONUCLEASE Y; FRAGMENT: UNP RESIDUES 79 - 90; SYNONYM: RNASE Y; EC: 3.1. - . -; ENGINEERED: YES LAMBDA ? MUS MUSCULUS 12 TLSRQHSTYTIE 7 LKKDGSH 15 IYICGVGDTIKEQFV 5 NYGMN 17 WIDTYTGDPTYADDFKG 3 GTY crystal 2.60A 20.40% FAB 11-DEC-17 20171211 IMMUNOGLOBULIN THREE - DIMENSIONAL STRUCTURE OF MURINE ANTI - P - AZOPHENYLARSONATE FAB 36 - 71. 1. X - RAY CRYSTALLOGRAPHY, SITE - DIRECTED MUTAGENESIS, AND MODELING OF THE COMPLEX WITH HAPTEN WITH HAPTEN KAPPA IGG1 MUS MUSCULUS 11 RASQDINNFLN 7 FTSRSQS 9 QQGNALPRT 5 SNGIN 17 YNNPGNGYIAYNEKFKG 12 SEYYGGSYKFDY crystal 1.90A 20.90% FAB 17-JAN-91 19910117 IMMUNE SYSTEM COMPLEX OF HUMAN CD40 ECTODOMAIN WITH LOB 7.4 FAB MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5; SYNONYM: B - CELL SURFACE ANTIGEN CD40,BP50,CD40L RECEPTOR,CDW40; ENGINEERED: YES; OTHER_DETAILS: RESIDUES 1 - 20 ARE POST - TRANSLATIONALLY CLEAVED. RESIDUES 124 - 194 ARE NOT VISIBLE IN THE ELECTRON DENSITY ? ? HOMO SAPIENS 11 SASQGINNYLN 7 YTSSLHS 9 QQYSNLPYT 5 EYIMH 17 GIIPNNGGTSYNQKFKD 13 REVYGRNYYALDY crystal 2.99A 18.70% FAB 18-DEC-17 20171218 METAL BINDING PROTEIN MONOCLONAL ANTIBODY TARGETING MATRIX METALLOPROTEINASE 7 MOLECULE: HEAVY CHAIN; ENGINEERED: YES; ? ? ESCHERICHIA COLI K-12 15 RASESFDSYGNTFVH 7 LVSNLES 9 QQNNEDPYT 5 DYNMD 17 HINPNNGGTFYNQKFKD 11 GGGLRRGPFAY crystal 2.30A 20.90% ? 19-DEC-17 20171219 IMMUNE SYSTEM MODEL OF GC1Q - FC COMPLEX BASED ON 7A EM MAP ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 4; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 21-DEC-17 20171221 TOXIN CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN SHIGA TOXIN STX2 B SUBUNIT AND NEUTRALISING NB113 MOLECULE: SHIGA - LIKE TOXIN 2 SUBUNIT B; SYNONYM: SLT - IIB,VEROCYTOTOXIN 2 SUBUNIT B,VEROTOXIN 2 SUBUNIT B; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 SYYMS 17 GINTGGVGTRYADSVKG 8 GEGGNRNY crystal 3.00A 17.10% HC-dimer 29-DEC-17 20171229 ANTITUMOR PROTEIN ANTI - TUMOR ANTIBODY 14F7 - DERIVED SINGLE CHAIN FRAGMENT VARIABLE (SCFV) ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.20A 18.70% scFv 08-JAN-18 20180108 IMMUNE SYSTEM HUMAN FCRN EXTRA - CELLULAR DOMAIN COMPLEXED WITH FAB FRAGMENT OF ROZANOLIXIZUMAB ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: FCGRT, FCRN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: B2M, CDABP0092, HDCMA22P; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 4; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.90A 23.40% FC 10-JAN-18 20180110 IMMUNE SYSTEM FC IN COMPLEX WITH ENGINEERED CALCIUM BINDING DOMAIN Z ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS; ORGANISM_TAXID: 1280; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.50A 20.50% FC 11-JAN-18 20180111 VIRAL PROTEIN 3H5 FAB BOUND TO EDIII OF DENV 2 XTAL FORM 1 MOLECULE: DOMAIN III OF DENGUE VIRUS 2; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RASESVDSFGKSFMHF 7 LASNLES 9 QQNNEVPFT 5 SYWLQ 17 AIWPGDDDTRYAQKFQG 8 KGGFAMDY crystal 2.90A 20.40% FAB 25-JAN-18 20180125 VIRAL PROTEIN 3H5 FAB BOUND TO EDIII OF DENV 2 XTAL FORM 2 MOLECULE: DOMAIN III OF DENGUE VIRUS 2; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RASESVDSFGKSFMHF 7 LASNLES 9 QQNNEVPFT 5 SYWLQ 17 AIWPGDDDTRYAQKFQG 8 KGGFAMDY crystal 2.20A 17.80% FAB 25-JAN-18 20180125 VIRAL PROTEIN 2C8 FAB BOUND TO EDIII OF DENV 2 MOLECULE: DOMAIN III OF DENGUE VIRUS 2; ENGINEERED: YES ? ? MUS MUSCULUS 11 RATKNIYNNLA 7 AATNLAD 9 QHFWHTPWT 5 DYYMT 19 LIRNKASGYTTEYSASVKG 10 AKWDGHYFDY crystal 2.00A 18.20% FAB 25-JAN-18 20180125 MEMBRANE PROTEIN ZOSUQUIDAR AND UIC2 FAB COMPLEX OF HUMAN - MOUSE CHIMERIC ABCB1 (ABCB1HM) MOLECULE: HUMAN - MOUSE CHIMERIC ABCB1 (ABCBHM); ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 10 SQSTHIPPWT 5 NYYIH 17 FISCYNGATFYNQKFKG 13 LPIQFGNFYPMDY ElectronMicroscopy N/A N/A FAB 02-FEB-18 20180202 MEMBRANE PROTEIN APO FORM OF UIC2 FAB COMPLEX OF HUMAN - MOUSE CHIMERIC ABCB1 (ABCB1HM) MOLECULE: APO FORM OF HUMAN - MOUSE CHIMERIC ABCB1 (ABCB1HM) IN COMPLEX WITH ANTIGEN BINDING FRAGMENT OF UIC2.; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 10 SQSTHIPPWT 5 NYYIH 17 FISCYNGATFYNQKFKG 13 LPIQFGNFYPMDY ElectronMicroscopy N/A N/A FAB 02-FEB-18 20180202 IMMUNE SYSTEM BAXB01 FAB FRAGMENT ? ? ? HOMO SAPIENS 11 RSSQRIMTYLN 7 VASHSQS 9 QQSFWTPLT 5 IYSMN 17 SIGSSGGTTYYADSVKG 9 SQWLYGMDV crystal 2.60A 21.60% FAB 07-FEB-18 20180207 IMMUNE SYSTEM A LLAMA - DERIVED JBP1 - TARGETING NANOBODY MOLECULE: NANOBODY; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INDMG 16 VISSGGSTNYADSVEG 14 NVRLREYRTTSYHY crystal 1.64A 16.50% HC-dimer 12-FEB-18 20180212 APOPTOSIS INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH AZD5991 MOLECULE: INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL - 1; SYNONYM: BCL - 2 - LIKE PROTEIN 3,BCL2 - L - 3,BCL - 2 - RELATED PROTEIN EAT / MCL1,MCL1 / EAT; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNTVN 7 SNNQRPS 11 AAWDDSLNAWV 5 SYSMN 17 SISSSSSYIYYADSVKG 10 QVGATWAFDI crystal 2.25A 19.50% FAB 18-FEB-18 20180218 MOTOR PROTEIN CRYSTAL STRUCTURE OF THE TPR DOMAIN OF KLC1 IN COMPLEX WITH THE C - TERMINAL PEPTIDE OF JIP1 MOLECULE: KINESIN LIGHT CHAIN 1,KINESIN LIGHT CHAIN 1,C - JUN - AMINO - TERMINAL KINASE - INTERACTING PROTEIN 1; SYNONYM: JNK - INTERACTING PROTEIN 1,ISLET - BRAIN 1,IB - 1,JNK MAP KINASE SCAFFOLD PROTEIN 1,MITOGEN - ACTIVATED PROTEIN KINASE 8 - INTERACTING PROTEIN 1; ENGINEERED: YES; OTHER_DETAILS: CHAINS A IS A CHIMERIC CONSTRUCT OF TPR DOMAIN OF KLC1 AND J THE C - TERMINAL PEPTIDE OF JIP1 FUSED VIA A (TGS) 10 LINKER., CHAINS A IS A CHIMERIC CONSTRUCT OF TPR DOMAIN OF KLC1 AND J THE C - TERMINAL PEPTIDE OF JIP1 FUSED VIA A (TGS) 10 LINKER.; ? ? LAMA 0 N/A 0 N/A 0 N/A 5 SYWMY 17 TINTGGGITYYKDSVKG 6 DMSGTY crystal 2.70A 23.40% HC-dimer 28-FEB-18 20180228 MOTOR PROTEIN CRYSTAL STRUCTURE OF THE TPR DOMAIN OF KLC1 IN COMPLEX WITH THE C - TERMINAL PEPTIDE OF TORSINA MOLECULE: KINESIN LIGHT CHAIN 1,TORSIN - 1A; SYNONYM: DYSTONIA 1 PROTEIN,TORSIN ATPASE 1,TORSIN FAMILY 1 MEMBER A; EC: 3.6.4. -; ENGINEERED: YES; OTHER_DETAILS: CHAIN A IS A FUSION IN A CHIMERIC CONSTRUCT OF TPR DOMAIN OF KLC1 AND THE C - TERMINAL PEPTIDE OF TORSINA VIA A (TGS) 10 LINKER.; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYWMY 17 TINTGGGITYYKDSVKG 6 DMSGTY crystal 2.29A 21.00% HC-dimer 28-FEB-18 20180228 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN BAFF IN COMPLEX WITH FAB FRAGMENT OF ANTI - BAFF ANTIBODY BELIMUMAB MOLECULE: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B; SYNONYM: B LYMPHOCYTE STIMULATOR,BLYS,B - CELL - ACTIVATING FACTOR,BAFF, DENDRITIC CELL - DERIVED TNF - LIKE MOLECULE,TNF - AND APOL - RELATED LEUKOCYTE EXPRESSED LIGAND 1,TALL - 1; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 QGDSLRSYYAS 7 GKNNRPS 11 SSRDSSGNHWV 5 NNAIN 17 GIIPMFGTAKYSQNFQG 14 SRDLLLFPHHALSP crystal 2.90A 19.10% FAB 09-MAR-18 20180309 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A V2 - DIRECTED, RV144 VACCINE - LIKE ANTIBODY FROM HIV - 1 INFECTION, CAP228 - 16H, BOUND TO A HETEROLOGOUS V2 PEPTIDE MOLECULE: CAP45 V2 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 GGVDIGSTLVH 7 DDSDRPS 10 QVWHSTSAVI 5 SSWIG 17 IIYPGDGETRYRASFQG 14 HGRGVREVINAFDI crystal 2.57A 21.00% FAB 10-MAR-18 20180310 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A V2P - REACTIVE RV144 VACCINE - LIKE ANTIBODY, CAP228 - 16H, IN COMPLEX WITH A SCAFFOLDED AUTOLOGOUS V1V2 MOLECULE: CAP228 AUTOLOGOUS SCAFFOLDED V1V2; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGVDIGSTLVH 7 DDSDRPS 10 QVWHSTSAVI 5 SSWIG 17 IIYPGDGETRYRASFQG 14 HGRGVREVINAFDI crystal 3.13A 22.60% FAB 10-MAR-18 20180310 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A V2P - REACTIVE RV144 VACCINE - LIKE ANTIBODY, CAP228 - 16H, IN COMPLEX WITH A HETEROLOGOUS CAP225 V1V2 MOLECULE: CAP225 SCAFFOLDED V1V2; ENGINEERED: YES ? ? HOMO SAPIENS 11 GGVDIGSTLVH 7 DDSDRPS 10 QVWHSTSAVI 5 SSWIG 17 IIYPGDGETRYRASFQG 14 HGRGVREVINAFDI crystal 2.30A 19.10% FAB 10-MAR-18 20180310 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A V2 - DIRECTED, RV144 VACCINE - LIKE ANTIBODY FROM HIV - 1 INFECTION, CAP228 - 3D, BOUND TO A HETEROLOGOUS V2 PEPTIDE MOLECULE: CAP45 V2 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 13 TRSSGSIASDYVQ 7 EDNQRPS 13 YCQSYDMTNHNWV 7 FSTYWIA 17 MIYPGDSDTKYSPSLQG 17 LLNNYDSSGFLYWYLDL crystal 2.60A 22.20% FAB 10-MAR-18 20180310 VIRAL PROTEIN STRUCTURE OF SINGLE DOMAIN ANTIBODY SD83 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NKAIG 17 CISKSGSWTYYTDSMRG 20 TTAGGGLCWDGTTFSRLASS crystal 2.00A 20.20% HC-dimer 12-MAR-18 20180312 VIRAL PROTEIN STRUCTURE OF H1 (A / SOLOMON ISLANDS / 3 / 06) INFLUENZA HEMAGGLUTININ IN COMPLEX WITH SD38 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IYAMD 16 TSFRDGSTNYADSVKG 16 SLYRDPLGVAGGMGVY crystal 2.80A 20.20% HC-dimer 12-MAR-18 20180312 VIRAL PROTEIN STRUCTURE OF H7 (A / SHANGHAI / 2 / 2013) INFLUENZA HEMAGGLUTININ IN COMPLEX SD36 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 2 MG 17 HINALGTRTYYSDSVKG 17 QGQWRAAPVAVAAEYEF crystal 2.64A 18.70% HC-dimer 12-MAR-18 20180312 VIRAL PROTEIN STRUCTURE OF B / BRISBANE / 60 / 2008 INFLUENZA HEMAGGLUTININ IN COMPLEX WITH SD83 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NKAIG 17 CISKSGSWTYYTDSMRG 20 TTAGGGLCWDGTTFSRLASS crystal 2.20A 19.30% HC-dimer 12-MAR-18 20180312 IMMUNE SYSTEM BEAT FC WITH IMPROVED HETERODIMERIZATION (Q3A - D84.4Q) ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: IGHG1, IGHG3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_COMMON: HUMAN; EXPRESSION_SYSTEM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.88A 23.30% FC 21-MAR-18 20180321 IMMUNE SYSTEM ABLIFT: ANTIBODY STABILITY AND AFFINITY OPTIMIZATION BY COMPUTATIONAL DESIGN OF THE VARIABLE LIGHT - HEAVY CHAIN INTERFACE MOLECULE: LIGHT CHAIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISNNLH 7 YVSQSVS 9 GQSNSWPRT 5 TYWIE 17 EILPGSGSTYYNEKFKG 7 GDGYYKY crystal 2.55A 19.60% ? 17-APR-18 20180417 MEMBRANE PROTEIN STRUCTURE OF THE BONGKREKIC ACID - INHIBITED MITOCHONDRIAL ADP / ATP CARRIER MOLECULE: MITOCHONDRIAL ADP / ATP CARRIER; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: SEQUENCE HAS Q302K MUTATION; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYTMG 19 IARITGSGSNTYYADSVKG 15 RDDGRMYQGFYDFEY crystal 3.30A 25.30% HC-dimer 17-APR-18 20180417 MEMBRANE PROTEIN CRYO - EM STRUCTURE OF THE ADENOSINE A2A RECEPTOR BOUND TO A MINIGS HETEROTRIMER MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 23-APR-18 20180423 IMMUNE SYSTEM HIGH - RESOLUTION STRUCTURE OF A THERAPEUTIC FULL - LENGTH ANTI - NPRA ANTIBODY WITH EXCEPTIONAL CONFORMATIONAL DIVERSITY ? ? ? HOMO SAPIENS 12 RASQSVRSNYLA 7 GASNRAT 9 QQISNSPPT 7 SRSASWS 18 RTYYRSHWYYEYAQSVKS 11 MDVPSFRYFDV crystal 1.80A 18.20% ? 30-APR-18 20180430 IMMUNE SYSTEM STRUCTURE OF GARP (LRRC32) IN COMPLEX WITH LATENT TGF - BETA1 AND MHG - 8 FAB MOLECULE: TRANSFORMING GROWTH FACTOR BETA - 1; FRAGMENT: MATURE; SYNONYM: TGF - BETA - 1; ENGINEERED: YES; OTHER_DETAILS: OBTAINED AFTER CLEAVAGE OF PRO - TGF - B1 BY FURIN AFTER ARGININE278.; ? ? MUS MUSCULUS 11 KASDHIKNWLA 7 GATSLEA 9 QQYWSTPWT 5 GYGIN 16 MIWSDGSTDYNSVLTS 13 DRNYYDYDGAMDY crystal 3.10A 23.50% FAB 30-APR-18 20180430 VIRUS LIKE PARTICLE CRYO - EM STRUCTURE OF BK POLYOMAVIRUS LIKE PARTICLE IN COMPLEX WITH SINGLE CHAIN ANTIBODY SCFV41F17 MOLECULE: CAPSID PROTEIN VP1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSHLA 7 DASSRAN 11 QQRSSWPPSLT 7 GGGYYWS 16 YIYYNRGTYYNPALKS 13 CVLGGYGSDAFDR ElectronMicroscopy N/A N/A FV 02-MAY-18 20180502 IMMUNE SYSTEM VARIABLE HEAVY - VARIABLE LIGHT DOMAIN AND FAB - ARM CROSSMABS WITH CHARGED RESIDUE EXCHANGES ? ? ? HOMO SAPIENS 12 RASQSVSSSYLA 7 GASSRAT 9 QQYGSSPLT 5 SYAMS 17 AISGSGGSTYYADSVKG 6 GSGFDY crystal 1.88A 19.70% FAB 07-MAY-18 20180507 HYDROLASE HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODY T27 MOLECULE: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; SYNONYM: ATP - BINDING CASSETTE SUB - FAMILY C MEMBER 7,CHANNEL CONDUCTANCE - CONTROLLING ATPASE,CAMP - DEPENDENT CHLORIDE CHANNEL; EC: 3.6.3.49; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INAMG 16 TFTSGGSTNYADFVEG 13 TVVVSRYGLTYDY crystal 2.49A 20.10% HC-dimer 16-MAY-18 20180516 HYDROLASE HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND T8 MOLECULE: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; SYNONYM: ATP - BINDING CASSETTE SUB - FAMILY C MEMBER 7,CHANNEL CONDUCTANCE - CONTROLLING ATPASE,CAMP - DEPENDENT CHLORIDE CHANNEL; EC: 3.6.3.49; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INNMG 16 IITRVGNTDYADSVKG 15 EITEQSRPFYLTDDY crystal 2.91A 22.70% HC-dimer 18-MAY-18 20180518 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - TAU ANTIBODY DMCBTAU - 27.1, DOUBLE MUTANT (S31Y, T100I) OF CBTAU - 27.1, IN COMPLEX WITH TAU PEPTIDE A8119B (RESIDUES 299 - 318) MOLECULE: HUMAN TAU PEPTIDE A8119 RESIDUES 299 - 318; FRAGMENT: FAB ANTIBODY FRAGMENT; ENGINEERED: YES ? ? HOMO SAPIENS 17 KSSQSVFYRDNNKNYLA 7 WASSRES 9 QHYFNIPHN 5 DYWTA 17 IIYSGDSDTRYHPSVQG 13 LDARVDAGWQLDS crystal 2.95A 22.40% FAB 18-MAY-18 20180518 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - TAU ANTIBODY DMCBTAU - 28.1, DOUBLE MUTANT (S32R, E35K) OF CBTAU - 28.1, IN COMPLEX WITH TAU PEPTIDE A7731 (RESIDUES 52 - 71) MOLECULE: TAU PEPTIDE A7731 (RESIDUES 52 - 71); FRAGMENT: FAB ANTIBODY FRAGMENT; ENGINEERED: YES ? ? HOMO SAPIENS 17 ESSQTLLYRSNKKNYLA 7 WASTPES 9 QQYYNSPYT 5 NYWIG 17 IIYPGDSDTRYSPPFQG 12 VGRPSKGGWFDP crystal 2.85A 23.90% FAB 18-MAY-18 20180518 HYDROLASE HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND G3A MOLECULE: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; SYNONYM: ATP - BINDING CASSETTE SUB - FAMILY C MEMBER 7,CHANNEL CONDUCTANCE - CONTROLLING ATPASE,CAMP - DEPENDENT CHLORIDE CHANNEL; EC: 3.6.3.49; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INNMG 16 IITRVGNTDYADSVKG 15 EITEQSRPFYLTDDY crystal 2.99A 19.30% HC-dimer 18-MAY-18 20180518 SUGAR BINDING PROTEIN STRUCTURE OF GALECTIN - 10 IN COMPLEX WITH THE FAB FRAGMENT OF A CHARCOT - LEYDEN CRYSTAL SOLUBILIZING ANTIBODY, 6F5 MOLECULE: GALECTIN - 10; SYNONYM: GAL - 10,CHARCOT - LEYDEN CRYSTAL PROTEIN,CLC,EOSINOPHIL LYSOPHOSPHOLIPASE,LYSOLECITHIN ACYLHYDROLASE; ENGINEERED: YES; OTHER_DETAILS: RECOMBINANT HUMAN GALECTIN - 10 WAS PRODUCED WITH AN N - TERMINAL CLEAVABLE HIS - TAG (MASTTHHHHHHDTDIPTTGGGSRPDDDDKENLYFQG) . BEFORE CRYSTALLIZATION, THE HIS - TAG WAS CLEAVED BY TEV PROTEASE.; ? ? LAMA GLAMA 14 AGTSSDIGYGNYVS 7 KVSRRAS 10 ASYRYRNNVV 5 SYAMS 17 AINSGGGSTSYADSVKG 12 PGDRLWYYRYDY crystal 1.91A 16.80% FAB 21-MAY-18 20180521 SUGAR BINDING PROTEIN STRUCTURE OF GALECTIN - 10 IN COMPLEX WITH THE FAB FRAGMENT OF A CHARCOT - LEYDEN CRYSTAL SOLUBILIZING ANTIBODY, 1D11 MOLECULE: GALECTIN - 10; SYNONYM: GAL - 10,CHARCOT - LEYDEN CRYSTAL PROTEIN,CLC,EOSINOPHIL LYSOPHOSPHOLIPASE,LYSOLECITHIN ACYLHYDROLASE; ENGINEERED: YES; OTHER_DETAILS: RECOMBINANT HUMAN GALECTIN - 10 WAS PRODUCED WITH AN N - TERMINAL CLEAVABLE PURIFICATION TAG (MASTTHHHHHHDTDIPTTGGGSRPDDDDKENLYFQ) . BEFORE CRYSTALLIZATION EXPERIMENTS, THE TAG WAS REMOVED BY TEV PROTEASE.; ? ? LAMA GLAMA 17 KGRPLACFLNEPYLQVD 7 QVCFGRR 15 SVLPDKYQVMVNGQS 5 DYAMS 17 GISWNGGSTYYAESMKG 14 DRNLGYRLGYPYDY crystal 1.90A 16.90% FAB 23-MAY-18 20180523 SUGAR BINDING PROTEIN STRUCTURE OF GALECTIN - 10 IN COMPLEX WITH THE FAB FRAGMENT OF A CHARCOT - LEYDEN CRYSTAL SOLUBILIZING ANTIBODY, 4E8 MOLECULE: GALECTIN - 10; ENGINEERED: YES; OTHER_DETAILS: RECOMBINANT HUMAN GALECTIN - 10 WAS PRODUCED WITH AN N - TERMINAL CLEAVABLE HIS - TAG (MASTTHHHHHHDTDIPTTGGGSRPDDDDKENLYFQ) . BEFORE CRYSTALLIZATION EXPERIMENTS, THE TAG WAS REMOVED BY TEV PROTEASE.; ? ? LAMA GLAMA 11 QGGNFGYYYGS 7 KDSERPS 10 QSADSSDNPV 7 TSYYAWS 16 VIASDGSTYYSPSLKS 15 YIRGSSWSGWSAYDY crystal 3.40A 30.70% FAB 23-MAY-18 20180523 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF PEPTIDE TRANSPORTER DTPA - NANOBODY IN MES BUFFER MOLECULE: DIPEPTIDE AND TRIPEPTIDE PERMEASE A; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYNMG 17 GISWTGRSADYPDSVKG 16 KQYGSRADYPWDDYDY crystal 3.29A 25.20% HC-dimer 13-JUN-18 20180613 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF PEPTIDE TRANSPORTER DTPA - NANOBODY IN COMPLEX WITH VALGANCICLOVIR MOLECULE: DIPEPTIDE AND TRIPEPTIDE PERMEASE A; ENGINEERED: YES; ? ? LAMA 0 N/A 0 N/A 0 N/A 5 SYNMG 17 GISWTGRSADYPDSVKG 16 KQYGSRADYPWDDYDY crystal 2.65A 21.70% HC-dimer 13-JUN-18 20180613 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF PEPTIDE TRANSPORTER DTPA - NANOBODY IN GLYCINE BUFFER MOLECULE: DIPEPTIDE AND TRIPEPTIDE PERMEASE A; ENGINEERED: YES; ? ? LAMA 0 N/A 0 N/A 0 N/A 5 SYNMG 17 GISWTGRSADYPDSVKG 16 KQYGSRADYPWDDYDY crystal 3.30A 21.20% HC-dimer 13-JUN-18 20180613 TRANSPORT PROTEIN CRYSTAL STRUCTURE OF E.COLI MULTIDRUG / H+ ANTIPORTER MDFA IN OUTWARD OPEN CONFORMATION WITH BOUND FAB FRAGMENT MOLECULE: MAJOR FACILITATOR SUPERFAMILY MULTIDRUG / H+ ANTIPORTER MDFA FROM E.COLI; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDIGYSLN 7 ATSNLDS 9 LQYASSPYT 5 IYGLH 16 MIWGGGRTDYNSALKS 9 NSGYGNLAY crystal 3.40A 25.90% FAB 20-JUN-18 20180620 VIRUS HIGH - RESOLUTION CRYO - EM OF FAB - LABELED HUMAN PARECHOVIRUS 3 MOLECULE: VP1; ? ? HOMO SAPIENS 11 RTSQSISNWLA 7 QASTLEN 10 QQYNNYMALT 5 SYAMS 17 AISGGGDSRYYADSVKG 12 RLGRVAEYYFDY ElectronMicroscopy N/A N/A FAB 20-JUN-18 20180620 IMMUNE SYSTEM LLAMA NANOBODY PORM_02 STRUCTURE DETERMINED AT ROOM TEMPERATURE BY IN - SITU DIFFRACTION ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RYNMG 17 SISWSGDRTYGTDSVKG 12 DRFLTRSVKYDY crystal 2.10A 17.30% HC-dimer 04-JUL-18 20180704 TRANSCRIPTION CRYSTAL STRUCTURE OF HUMAN MEDIATOR SUBUNIT MED23 MOLECULE: MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23; SYNONYM: ACTIVATOR - RECRUITED COFACTOR 130 KDA COMPONENT,ARC130, COFACTOR REQUIRED FOR SP1 TRANSCRIPTIONAL ACTIVATION SUBUNIT 3,CRSP COMPLEX SUBUNIT 3,MEDIATOR COMPLEX SUBUNIT 23,PROTEIN SUR - 2 HOMOLOG, HSUR - 2,TRANSCRIPTIONAL COACTIVATOR CRSP130,VITAMIN D3 RECEPTOR - INTERACTING PROTEIN COMPLEX 130 KDA COMPONENT,DRIP130; ENGINEERED: YES; OTHER_DETAILS: HUMAN MED23 SUBUNIT WITH A C - TERMINAL PURIFICATION TAG; ? ? LAMA 0 N/A 0 N/A 0 N/A 5 IYTMG 19 VARTTWTPGSTKYADSVKG 15 CAYGTCYYGDRAYEY crystal 2.80A 20.10% HC-dimer 06-JUL-18 20180706 IMMUNE SYSTEM FAB CBTAU - 22.1 IN COMPLEX WITH TAU PEPTIDE V1088 - 5 MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSLLHRSGHKYLH 7 LGSNRAS 9 MQTLQTPWT 5 DYNVH 17 RISPNSGGTKYAQKFQG 12 GHCDGTTCSRAY crystal 2.63A 21.70% FAB 06-JUL-18 20180706 IMMUNE SYSTEM FAB DMCBTAU - 22.1 IN COMPLEX WITH TAU PEPTIDE V1088 - 23 MOLECULE: MICROTUBULE - ASSOCIATED PROTEIN TAU; FRAGMENT: FAB ANTIBODY FRAGMENT; SYNONYM: NEUROFIBRILLARY TANGLE PROTEIN,PAIRED HELICAL FILAMENT - TAU, PHF - TAU; ENGINEERED: YES ? ? HOMO SAPIENS 16 RSSQSLLHRSGHKYLH 7 LGSNRAS 9 MQTLQTPWT 5 DYFVH 17 RIRPNSGGTKYAQKFQG 12 GHCDGTTCSRAY crystal 1.95A 22.30% FAB 09-JUL-18 20180709 SIGNALING PROTEIN STRUCTURE OF LRP6 P3E3P4E4 IN COMPLEX WITH VHH L - P2 - B10 MOLECULE: LOW - DENSITY LIPOPROTEIN RECEPTOR - RELATED PROTEIN 6; SYNONYM: LRP - 6; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYTIG 17 AIHWDGGQTYYADSVKG 16 RGRRYFDFTYSDVYDY crystal 2.60A 20.10% HC-dimer 11-JUL-18 20180711 SIGNALING PROTEIN STRUCTURE OF LRP6 P3E3P4E4 IN COMPLEX WITH VHH L - P2 - D07 MOLECULE: LOW - DENSITY LIPOPROTEIN RECEPTOR - RELATED PROTEIN 6; SYNONYM: LRP - 6; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 IYTIG 17 EITWSGGSTYYADSVKG 10 ITYTRGIYKY crystal 2.90A 21.30% HC-dimer 11-JUL-18 20180711 STRUCTURAL PROTEIN STRUCTURE OF THE NANOBODY - STABILIZED GELSOLIN D187N VARIANT (SECOND DOMAIN) MOLECULE: GELSOLIN; SYNONYM: AGEL,ACTIN - DEPOLYMERIZING FACTOR,ADF,BREVIN; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: SECOND DOMAIN (G2) OF GELSOLIN PATHOLOGICAL VARIANT D187N ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SFVMG 17 SISRSGSVTRYADSAKG 18 DLHRPYGPGSQRTDDYDT crystal 1.90A 20.20% HC-dimer 11-JUL-18 20180711 IMMUNE SYSTEM FAB FRAGMENT OF ANTIBODY AGAINST FULLERENE C60 ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 RYTMH 17 YINPSSGYTEYNQKFRD 10 GDYRYGGTAY crystal 1.92A 19.10% FAB 18-JUL-18 20180718 VIRAL PROTEIN SCHMALLENBERG VIRUS GLYCOPROTEIN GC HEAD DOMAIN IN COMPLEX WITH SCFV 1C11 MOLECULE: ENVELOPMENT POLYPROTEIN; FRAGMENT: GLYCOPROTEIN GC HEAD DOMAIN; SYNONYM: M POLYPROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 17 KSSQSLLYSSNQKNYLA 7 WASTRES 9 QQYYSFPPT 5 DYNMC 17 YIDPYNGLTSYNPKFKG 11 NYYGRSYAMDY crystal 2.84A 21.80% FV 19-JUL-18 20180719 VIRAL PROTEIN SCHMALLENBERG VIRUS GLYCOPROTEIN GC HEAD DOMAIN IN COMPLEX WITH SCFV 4B6 MOLECULE: ENVELOPMENT POLYPROTEIN; FRAGMENT: GLYCOPROTEIN GC HEAD DOMAIN; SYNONYM: M POLYPROTEIN; ENGINEERED: YES ? ? MUS MUSCULUS 11 SASQGISYYLN 7 YTSSLHS 9 QQYSKLPWT 6 SDSAWN 16 YISYSGSTSYNPSLKS 11 WGDGYYLYWYF crystal 3.17A 20.20% FV 19-JUL-18 20180719 CELL INVASION PLASMODIUM FALCIPARUM PFS48 / 45 C - TERMINAL DOMAIN BOUND TO MONOCLONAL ANTIBODY 85RF45.1 MOLECULE: GAMETOCYTE SURFACE PROTEIN P45 / 48; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVS 7 RDDQRPD 11 FCHSYSTGMYI 5 NYWMS 17 SISNIGGTIYYPDSVKG 10 DLRMSDYFDY crystal 3.23A 26.20% ? 25-JUL-18 20180725 VIRAL PROTEIN GI.1 HUMAN NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANO - 7 MOLECULE: CAPSID PROTEIN VP1; SYNONYM: CP,P59; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 NYYSG 19 LASIRWSDSTTNYADSVKG 8 RRLATYDY crystal 1.58A 15.60% HC-dimer 30-JUL-18 20180730 VIRAL PROTEIN GI.1 HUMAN NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANO - 62 MOLECULE: CAPSID PROTEIN VP1; SYNONYM: CP,P59; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 VSVMA 17 GMRWSGMTTYSADSVKD 17 RSRFIVGVPQARDLYDY crystal 2.09A 18.00% HC-dimer 30-JUL-18 20180730 VIRAL PROTEIN GI.1 HUMAN NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANO - 62 AND 2 - FUCOSYLLACTOSE (2FL) MOLECULE: CAPSID PROTEIN VP1; SYNONYM: CP,P59; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 VSVMA 17 GMRWSGMTTYSADSVKD 17 RSRFIVGVPQARDLYDY crystal 1.83A 16.30% HC-dimer 30-JUL-18 20180730 VIRAL PROTEIN GI.1 HUMAN NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANO - 94 MOLECULE: CAPSID PROTEIN VP1; SYNONYM: CP,P59; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 INSMG 16 TISEAGTTTYADSVRG 13 YIQLDSTIWFRAY crystal 2.31A 19.40% HC-dimer 30-JUL-18 20180730 VIRAL PROTEIN GI.1 HUMAN NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANO - 94 AND 2 - FUCOSYLLACTOSE (2FL) MOLECULE: CAPSID PROTEIN VP1; SYNONYM: CP,P59; ENGINEERED: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 INSMG 16 TISEAGTTTYADSVRG 13 YIQLDSTIWFRAY crystal 2.30A 17.40% HC-dimer 30-JUL-18 20180730 IMMUNE SYSTEM ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY NB80 MOLECULE: BETA - 1 ADRENERGIC RECEPTOR; SYNONYM: BETA - 1 ADRENORECEPTOR,BETA - T; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INTMG 16 AIHSGGSTNYANSVKG 12 KDYGAVLYEYDY crystal 2.80A 28.60% HC-dimer 31-JUL-18 20180731 IMMUNE SYSTEM ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY NB6B9 MOLECULE: BETA - 1 ADRENERGIC RECEPTOR; SYNONYM: BETA - 1 ADRENORECEPTOR,BETA - T; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 2.70A 24.30% HC-dimer 31-JUL-18 20180731 IMMUNE SYSTEM ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY NB6B9 MOLECULE: BETA - 1 ADRENERGIC RECEPTOR; SYNONYM: BETA - 1 ADRENORECEPTOR,BETA - T; ENGINEERED: YES; MUTATION: YES; ? ? ESCHERICHIA COLI 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 2.76A 26.60% HC-dimer 31-JUL-18 20180731 IMMUNE SYSTEM ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY NB6B9 MOLECULE: BETA - 1 ADRENERGIC RECEPTOR; SYNONYM: BETA - 1 ADRENORECEPTOR,BETA - T; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 2.50A 24.90% HC-dimer 31-JUL-18 20180731 ELECTRON TRANSPORT ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY NB6B9 MOLECULE: BETA - 1 ADRENERGIC RECEPTOR; SYNONYM: BETA - 1 ADRENORECEPTOR,BETA - T; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 LNIMG 16 AIHSGGTTNYANSVKG 12 KDFGAIIYDYDY crystal 2.80A 24.20% HC-dimer 31-JUL-18 20180731 OXIDOREDUCTASE MUTANT OXIDOREDUCTASE FRAGMENT OF MOUSE QSOX1 IN COMPLEX WITH AN ANTIBODY FAB MOLECULE: SULFHYDRYL OXIDASE 1; SYNONYM: MSOX,QUIESCIN Q6,SKIN SULFHYDRYL OXIDASE; EC: 1.8.3.2; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVSYMY 7 RTSNLAS 9 QQYHSYPLT 5 SYYIH 17 WIYPGSYNTEYSEKFKG 7 SEDWFAY crystal 1.94A 19.60% FAB 21-AUG-18 20180821 IMMUNE SYSTEM HPD - 1 / NBO1A FAB COMPLEX MOLECULE: PROGRAMMED CELL DEATH PROTEIN 1; SYNONYM: HPD - 1; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 7 SASQDLN 7 HTSSLHS 6 QYYLLT 5 NFYIH 17 SIYPNYGDTAYNQKFKD 8 GYSYAMDY crystal 2.20A 21.70% FAB 29-AUG-18 20180829 VIRAL PROTEIN STRUCTURE OF INFLUENZA HEMAGGLUTININ ECTODOMAIN (A / DUCK / ALBERTA / 35 / 76) IN COMPLEX WITH FISW84 FAB FRAGMENT MOLECULE: HEMAGGLUTININ; ? ? HOMO SAPIENS 11 RASQSVNTNVA 7 GASTRAT 10 QQYSNWPPIT 5 SYGMA 17 FISATGLSTYFADSVKG 13 MRRTMIAFGGNDF ElectronMicroscopy N/A N/A FAB 04-SEP-18 20180904 VIRAL PROTEIN STRUCTURE OF FULL - LENGTH INFLUENZA HEMAGGLUTININ (A / DUCK / ALBERTA / 35 / 76) IN COMPLEX WITH FISW84 FAB FRAGMENT MOLECULE: HEMAGGLUTININ; ? ? HOMO SAPIENS 11 RASQSVNTNVA 7 GASTRAT 10 QQYSNWPPIT 5 SYGMA 17 FISATGLSTYFADSVKG 13 MRRTMIAFGGNDF ElectronMicroscopy N/A N/A FAB 04-SEP-18 20180904 IMMUNE SYSTEM STRUCTURE OF FISW84 FAB FRAGMENT ? ? ? HOMO SAPIENS 11 RASQSVNTNVA 7 GASTRAT 10 QQYSNWPPIT 5 SYGMA 17 FISATGLSTYFADSVKG 13 MRRTMIAFGGNDF crystal 1.87A 18.40% FAB 06-SEP-18 20180906 PROTEIN FIBRIL CRYO - EM STRUCTURE OF CARDIAC AMYLOID FIBRILS FROM AN IMMUNOGLOBULIN LIGHT CHAIN (AL) AMYLOIDOSIS PATIENT. ? ? ? HOMO SAPIENS 13 TGSSASIASHYVQ 0 10 QSYDGNNHWV 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 06-OCT-18 20181006 MEMBRANE PROTEIN CRYOEM STRUCTURE OF HUMAN FULL - LENGTH ALPHA1BETA3GAMMA2L GABA (A) R IN COMPLEX WITH PICROTOXIN AND MEGABODY MB38. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS; ORGANISM_COMMON: BOVINE; ORGANISM_TAXID: 9913; GENE: GABRA1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293SGNTI-; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: GABRB3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293SGNTI-; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: GABRG2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293SGNTI-; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 4; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 08-OCT-18 20181008 MEMBRANE PROTEIN CRYOEM STRUCTURE OF HUMAN FULL - LENGTH HETEROMERIC ALPHA1BETA3GAMMA2L GABA (A) R IN COMPLEX WITH PICROTOXIN, GABA AND MEGABODY MB38. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS, HOMO SAPIENS; ORGANISM_COMMON: BOVINE, HUMAN; ORGANISM_TAXID: 9913, 9606; GENE: GABRA1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: GABRB3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: GABRG2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S; EXPRESSION_SYSTEM_ATCC_NUMBER: 30222; MOL_ID: 4; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 08-OCT-18 20181008 MEMBRANE PROTEIN CRYOEM STRUCTURE OF HUMAN FULL - LENGTH ALPHA1BETA3GAMMA2L GABA (A) R IN COMPLEX WITH BICUCULLINE AND MEGABODY MB38. ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: BOS TAURUS, HOMO SAPIENS; ORGANISM_COMMON: BOVINE, HUMAN; ORGANISM_TAXID: 9913, 9606; GENE: GABRA1; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: GABRB3; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 3; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; GENE: GABRG2; EXPRESSION_SYSTEM: HOMO SAPIENS; EXPRESSION_SYSTEM_TAXID: 9606; EXPRESSION_SYSTEM_CELL_LINE: HEK293S; EXPRESSION_SYSTEM_ATCC_NUMBER: 3022; MOL_ID: 4; ORGANISM_SCIENTIFIC: LAMA GLAMA; ORGANISM_TAXID: 9844; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 Neither light nor heavy chain could be assigned 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A HC-dimer 08-OCT-18 20181008 IMMUNE SYSTEM HETEROMERIC TANDEM IGG4 / IGG1 FC ? ? IGG4 MOL_ID: 1; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.31A 25.90% FC 21-OCT-18 20181021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SEMA DOMAIN OF THE MET RECEPTOR IN COMPLEX WITH FAB MOLECULE: HEPATOCYTE GROWTH FACTOR RECEPTOR; SYNONYM: HGF RECEPTOR,HGF / SF RECEPTOR,PROTO - ONCOGENE C - MET,SCATTER FACTOR RECEPTOR,SF RECEPTOR,TYROSINE - PROTEIN KINASE MET; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISSWLA 7 AASSLQS 9 LQANSFPPT 7 SSVYYWS 16 VIYPSGNTYYSPSLKS 8 TIYDLFDI crystal 3.10A 20.50% FAB 25-OCT-18 20181025 IMMUNE SYSTEM CRYSTAL STRUCTURE OF EPCAM IN COMPLEX WITH SCFV MOLECULE: EPITHELIAL CELL ADHESION MOLECULE; SYNONYM: EP - CAM,ADENOCARCINOMA - ASSOCIATED ANTIGEN,CELL SURFACE GLYCOPROTEIN TROP - 1,EPITHELIAL CELL SURFACE ANTIGEN,EPITHELIAL GLYCOPROTEIN,EGP,EPITHELIAL GLYCOPROTEIN 314,HEGP314,KS 1 / 4 ANTIGEN, KSA,MAJOR GASTROINTESTINAL TUMOR - ASSOCIATED PROTEIN GA733 - 2,TUMOR - ASSOCIATED CALCIUM SIGNAL TRANSDUCER 1; ENGINEERED: YES; OTHER_DETAILS: PCA IS PYROGLUTAMIC ACID POST TRANSLATIONAL MODIFICATION ? ? HOMO SAPIENS 16 RSTKSLLHSDGITYLY 7 QLSNLAS 15 AQNLEIPRTFGCGTK 7 HSDGITY 13 QLLIYQLSNLASG 26 AQNLEIPRTFGCGTKLEIQVQLVQSG crystal 2.35A 23.30% scFv 25-OCT-18 20181025 MEMBRANE PROTEIN CRYSTAL STRUCTURE OF THE KDEL RECEPTOR BOUND TO SYNTHETIC NANOBODY. MOLECULE: ER LUMEN PROTEIN - RETAINING RECEPTOR 2; SYNONYM: KDEL ENDOPLASMIC RETICULUM PROTEIN RETENTION RECEPTOR 2,KDEL RECEPTOR 2; ENGINEERED: YES; ? ? UNIDENTIFIED 0 N/A 0 N/A 0 N/A 5 RWSMT 17 AIRSAGHWTHYADSVKG 12 KDEGDFSYWYDY crystal 2.23A 21.30% HC-dimer 15-NOV-18 20181115 BLOOD CLOTTING DISCOVERY AND CHARACTERISATION OF AN ANTIBODY THAT SELECTIVELY MODULATES THE INHIBITORY ACTIVITY OF PLASMINOGEN ACTIVATOR INHIBITOR - 1 MOLECULE: PLASMINOGEN ACTIVATOR INHIBITOR 1; SYNONYM: PAI - 1,ENDOTHELIAL PLASMINOGEN ACTIVATOR INHIBITOR,SERPIN E1; ENGINEERED: YES; MUTATION: YES; ? ? ESCHERICHIA COLI 11 RASEGIYHNLA 7 KASSLAS 9 QQYSNYPLT 5 SYAIS 17 GIIPTFGTANYAQKFQG 12 ERRQWLEGHFDY crystal 2.90A 22.00% FAB 21-NOV-18 20181121 VIRAL PROTEIN RIFT VALLEY FEVER VIRUS GN IN COMPLEX WITH A NEUTRALIZING ANTIBODY FRAGMENT MOLECULE: GLYCOPROTEIN; ENGINEERED: YES; ? ? ORYCTOLAGUS CUNICULUS 13 QASQSVYNNYLLS 7 SASTLAS 13 LGSYDGNSADCLA 5 SDHMS 16 IIYASGTTYYASWAKG 9 YPNYPTDNL crystal 1.98A 20.50% ? 23-NOV-18 20181123 IMMUNE SYSTEM STRUCTURE OF HUMAN NKP46 IN COMPLEX WITH ANTIBODY NKP46 - 1 AND NKP46 - 4 MOLECULE: NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; SYNONYM: LYMPHOCYTE ANTIGEN 94 HOMOLOG,NK CELL - ACTIVATING RECEPTOR, NATURAL KILLER CELL P46 - RELATED PROTEIN,HNKP46; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 11 RASENIYSNLA 7 AATNLAD 9 QHFWGTPRT 5 SFTMH 17 YINPSSGYTEYNQKFKD 8 GSSRGFDY crystal 2.90A 19.10% FAB 27-NOV-18 20181127 IMMUNE SYSTEM STRUCTURE OF HUMAN NKP46 IN COMPLEX WITH ANTIBODY NKP46 - 1 AND NKP46 - 4 WITH ANTIBODY NKP46 - 1 AND NKP46 - 4 ? ? SYNTHETIC CONSTRUCT 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTRPWT 5 DYVIN 17 EIYPGSGTNYYNEKFKA 11 RGRYGLYAMDY crystal 1.75A 19.70% FAB 27-NOV-18 20181127 IMMUNE SYSTEM ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY NB80 MOLECULE: THIOREDOXIN 1,BETA - 1 ADRENERGIC RECEPTOR; SYNONYM: TRX - 1,BETA - 1 ADRENORECEPTOR,BETA - T; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 INTMG 16 AIHSGGSTNYANSVKG 12 KDYGAVLYEYDY crystal 2.70A 24.10% HC-dimer 30-NOV-18 20181130 PROTEIN FIBRIL AL AMYLOID FIBRIL FROM A LAMBDA 1 LIGHT CHAIN MOLECULE: LAMBDA 1 LIGHT CHAIN FRAGMENT, RESIDUES 3 - 118; LAMBDA ? HOMO SAPIENS 13 SGRSSNIGRNLVK 7 SNDQRPS 11 AAWDATLNAWV 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 02-DEC-18 20181202 SIGNALING PROTEIN THE NZ - 1 FAB COMPLEXED WITH THE PDZ TANDEM FRAGMENT OF A. AEOLICUS S2P HOMOLOG WITH THE PA12 TAG INSERTED BETWEEN THE RESIDUES 181 AND 186 MOLECULE: PDZ TANDEM FRAGMENT WITH PA TAG; FRAGMENT: UNP RESIDUES 115 - 181 AND 185 - 292; EC: 3.4.24. -; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVN 7 RDDKRPD 10 FCHSYSSGIV 5 NYGMA 17 SISAGGDKTYYGDSVKG 8 TSRVYFDY crystal 2.00A 21.50% FAB 05-SEP-18 20180905 SIGNALING PROTEIN THE NZ - 1 FAB COMPLEXED WITH THE PDZ TANDEM FRAGMENT OF A. AEOLICUS S2P HOMOLOG WITH THE PA12 TAG INSERTED BETWEEN THE RESIDUES 263 AND 266 MOLECULE: PUTATIVE ZINC METALLOPROTEASE AQ_1964,PUTATIVE ZINC METALLOPROTEASE AQ_1964; FRAGMENT: UNP RESIDUES 115 - 263 AND 266 - 292; EC: 3.4.24. -; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 13 KRSTGNIGSNYVN 7 RDDKRPD 10 FCHSYSSGIV 5 NYGMA 17 SISAGGDKTYYGDSVKG 8 TSRVYFDY crystal 4.00A 21.60% FAB 05-SEP-18 20180905 IMMUNE SYSTEM COMPLEX OF HLA - A *11:01 BINDING TO ALLOANTIBODY 2E3 MOLECULE: BETA - 2 - MICROGLOBULIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TLRSGINVGPYNIY 7 YKSDPDK 15 EADYYCMIWHNNAWV 5 GYYMH 17 WINPNSGGTSYAQKFQG 12 VTTVIAGPVFDY crystal 2.40A 19.90% ? 08-SEP-18 20180908 IMMUNE SYSTEM ANTIBODY 64M - 5 FAB IN COMPLEX WITH DT (6 - 4) T MOLECULE: DNA (5' - D ( * (64T) P * (5PY) ) - 3'); ENGINEERED: YES ? ? MUS MUSCULUS 16 RSSQNIVHSNGYTYLE 7 TVSNRFS 8 FRGSHVPT 5 NYWMH 17 TIYPGNSDTTYSQKFKG 11 RNYGSSYAMDY crystal 2.00A 19.20% FAB 10-SEP-18 20180910 IMMUNE SYSTEM ANTIBODY 64M - 5 FAB IN LIGAND - FREE FORM ? ? ? MUS MUSCULUS 16 RSSQNIVHSNGYTYLE 7 TVSNRFS 8 FRGSHVPT 5 NYWMH 17 TIYPGNSDTTYSQKFKG 11 RNYGSSYAMDY crystal 2.50A 22.90% FAB 10-SEP-18 20180910 VIRUS CRYO - EM STRUCTURE OF IMMATURE DENGUE VIRUS SEROTYPE 3 IN COMPLEX WITH HUMAN ANTIBODY 1H10 FAB AT PH 8.0. MOLECULE: ENVELOPE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGGSSNIGSSYVY 7 RNNERPS 11 AAWDDSLRGQV 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 10-SEP-18 20180910 VIRUS CRYO - EM STRUCTURE OF IMMATURE DENGUE VIRUS SEROTYPE 3 IN COMPLEX WITH HUMAN ANTIBODY 1H10 FAB AT PH 5.0 (CLASS I PARTICLE) MOLECULE: ENVELOPE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGGSSNIGSSYVY 7 RNNERPS 11 AAWDDSLRGQV 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 10-SEP-18 20180910 VIRUS CRYO - EM STRUCTURE OF IMMATURE DENGUE VIRUS SEROTYPE 3 IN COMPLEX WITH HUMAN ANTIBODY 1H10 FAB AT PH 5.0 (CLASS II PARTICLE) MOLECULE: ENVELOPE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGGSSNIGSSYVY 7 RNNERPS 11 AAWDDSLRGQV 0 N/A 0 N/A 0 N/A ElectronMicroscopy N/A N/A LC-dimer 10-SEP-18 20180910 STRUCTURAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R13 MOLECULE: NSMGNGC; SYNONYM: GLYCOPROTEIN N,GN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TLPSDINVGSYNIY 7 YYSDSDK 15 EADYYCMIWPSNAWV 7 SGGYYWS 16 YIYDSGSTYYNPSLKS 15 LPYCSGRICRPRTDY crystal 2.00A 18.30% FV 13-SEP-18 20180913 STRUCTURAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R15 MOLECULE: NSMGNGC; SYNONYM: GLYCOPROTEIN N,GN; ENGINEERED: YES ? ? HOMO SAPIENS 11 SGDKLGDKYVC 7 QDSKRPS 8 QACDSSTV 5 TYYWS 16 YIYYSGSTNYNPSLKT 10 SDYGDLIFDY crystal 2.41A 19.70% FV 13-SEP-18 20180913 STRUCTURAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R17 MOLECULE: NSMGNGC; SYNONYM: GLYCOPROTEIN N,GN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPS 12 QVWDSSSDHLYV 5 DYYMS 17 YISPGGSTIYYADSVKG 10 SADVYNWFDP crystal 3.20A 24.30% FV 13-SEP-18 20180913 STRUCTURAL PROTEIN / IMMUNE SYSTEM STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R12 MOLECULE: NSMGNGC; SYNONYM: GLYCOPROTEIN N,GN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TLPSDISVSSYNIY 7 YYSDSDK 15 EADYYCMIWPSNAWV 5 ELSMH 17 GFDREDGETIYAQKFQG 12 DPIRYNWNYGDY crystal 2.70A 22.70% FV 14-SEP-18 20180914 VIRAL PROTEIN CRYSTAL STRUCTURE OF HIV - 1 ENV CONM SOSIP.V7 IN COMPLEX WITH BNAB PGT124 AND 35O22 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.90A 25.00% FAB 16-SEP-18 20180916 IMMUNE SYSTEM CRYSTAL STRUCTURE OF H7 HEMAGGLUTININ FROM A / ANHUI / 1 / 2013 IN COMPLEX WITH A HUMAN NEUTRALIZING ANTIBODY L4A - 14 MOLECULE: HEMAGGLUTININ; SYNONYM: H7 HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSIASNYVQ 7 EYNQRPS 11 YCQSYDSANRV 5 SYAIH 17 LISYDGSNKYYADSVKG 14 HGSGGEVGSNWFDP crystal 3.30A 22.90% FAB 03-OCT-18 20181003 IMMUNE SYSTEM CRYSTAL STRUCTURE OF H7 HEMAGGLUTININ FROM A / ANHUI / 1 / 2013 IN COMPLEX WITH A HUMAN NEUTRALIZING ANTIBODY L4B - 18 MOLECULE: HEMAGGLUTININ; SYNONYM: H7 HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 13 TRSSGSIASNYVQ 7 EDNQRPS 11 YCQSYDSSNVV 5 SYAMS 17 AISGSGGSTYYADSVKG 16 DRLLWFGELLFEGFDY crystal 3.32A 20.60% FAB 03-OCT-18 20181003 IMMUNE SYSTEM CRYSTAL STRUCTURE OF H7 HEMAGGLUTININ FROM A / ANHUI / 1 / 2013 IN COMPLEX WITH A HUMAN NEUTRALIZING ANTIBODY L3A - 44 MOLECULE: HEMAGGLUTININ; SYNONYM: H7 HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGSSSNIGAGFDVH 7 GNSFRPS 11 QSYDSSLSGVV 5 GYYWS 16 EINHSGGTNYNPSLKS 13 GVWEGSGSDNFDY crystal 3.50A 20.20% FAB 03-OCT-18 20181003 IMMUNE SYSTEM X - RAY CRYSTAL STRUCTURE OF FC AND PEPTIDE COMPLEX ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.00A 20.20% FC 08-NOV-18 20181108 IMMUNE SYSTEM X - RAY CRYSTAL STRUCTURE OF COVALENT - BONDED COMPLEX OF FC AND PEPTIDE ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_TAXID: 10029; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.00A 22.70% FC 08-NOV-18 20181108 PROTEIN TRANSPORT STRUCTURE OF A SUBSTRATE ENGAGED SECA - SECY PROTEIN TRANSLOCATION MACHINE MOLECULE: TRANSLOCATING PEPTIDE; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 RYSMR 16 GMSAGDRSSYEDSVKG 6 NVGFEY ElectronMicroscopy N/A N/A HC-dimer 21-NOV-18 20181121 IMMUNE SYSTEM CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY AVFLUIGG01 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? HOMO SAPIENS 14 TGTSSDVGDYNYVS 7 DVNKRPS 10 SSYTSSNTWV 5 SYYWS 16 YLFDSGSTKYNPSLTS 10 GFWGLDGFDI crystal 2.30A 20.80% FAB 30-NOV-18 20181130 IMMUNE SYSTEM CRYSTAL STRUCTURE OF INFLUENZA A VIRUS H5 HEMAGGLUTININ GLOBULAR HEAD IN COMPLEX WITH THE FAB OF ANTIBODY 3C11 MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLLHSDGYNYLD 7 LGSHRAS 8 MQALQTPD 5 SYYIS 17 RIDPSDSDTNYRPSFQG 17 RATYYYGSGSYFDAFDI crystal 2.33A 20.90% FAB 30-NOV-18 20181130 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF 5A SCFV COMPLEXED WITH YFV - CHINA SE IN POSTFUSION STATE MOLECULE: ENVELOPE PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGSWLA 7 KASSLES 9 QQYNNYSYT 5 NHHWS 16 YISYSGKSNYNPSLKS 15 EYRDDTNYYYYSLDV crystal 2.40A 21.20% FV 04-DEC-18 20181204 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF 5A SCFV IN COMPLEX WITH YFV - 17D SE IN POSTFUSION STATE MOLECULE: ENVELOPE PROTEIN E; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGSWLA 7 KASSLES 9 QQYNNYSYT 5 NHHWS 16 YISYSGKSNYNPSLKS 15 EYRDDTNYYYYSLDV crystal 3.60A 27.90% FV 04-DEC-18 20181204 VIRAL PROTEIN / IMMUNE SYSTEM CRYSTAL STRUCTURE OF 5A SCFV IN COMPLEX WITH YFV - 17D SE IN PREFUSION STATE MOLECULE: ENVELOPE PROTEIN E; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSIGSWLA 7 KASSLES 9 QQYNNYSYT 5 NHHWS 16 YISYSGKSNYNPSLKS 15 EYRDDTNYYYYSLDV crystal 2.90A 23.90% FV 04-DEC-18 20181204 AFLATOXIN B1 - BINDING PROTEIN SOLUTION STRUCTURE OF CAMELID NANOBODY NB26 AGAINST AFLATOXIN B1 ? ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 6 SSYAMG 17 AVVNWSGRRTYYADSVK 14 AGKWDGSYYGAPDY NMR N/A N/A HC-dimer 17-DEC-18 20181217 VIRAL PROTEIN / IMMUNE SYSTEM COMPLEX STRUCTURE OF MAB 4.2 - SCFV WITH LOUPING ILL VIRUS ENVELOPE PROTEIN DOMAIN III MOLECULE: ENVELOPE; FRAGMENT: DOMAIN III; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 KAQTLAD 10 QHFWSTPPWT 5 DYVIG 17 EIYPGSGTTYYNEKFKD 11 GEDGYYIALDY crystal 1.80A 17.10% FV 10-JAN-19 20190110 VIRAL PROTEIN / IMMUNE SYSTEM COMPLEX STRUCTURE OF MAB 4.2 - SCFV WITH TICK - BORNE ENCEPHALITIS VIRUS ENVELOPE PROTEIN DOMAIN III MOLECULE: ENVELOPE PROTEIN; FRAGMENT: DOMAIN III; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 KAQTLAD 10 QHFWSTPPWT 5 DYVIG 17 EIYPGSGTTYYNEKFKD 11 GEDGYYIALDY crystal 1.80A 18.00% FV 10-JAN-19 20190110 VIRAL PROTEIN / IMMUNE SYSTEM COMPLEX STRUCTURE OF MAB 4.2 - SCFV WITH TICK - BORNE ENCEPHALITIS VIRUS ENVELOPE PROTEIN MOLECULE: ENVELOPE PROTEIN E; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 KAQTLAD 10 QHFWSTPPWT 5 DYVIG 17 EIYPGSGTTYYNEKFKD 11 GEDGYYIALDY crystal 3.29A 20.80% FV 10-JAN-19 20190110 SIGNALING PROTEIN HUA21 - SCFV IN COMPLEX WITH THE EXTRACELLULAR DOMAIN (ECD) OF HER2 MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN,MLN 19,PROTO - ONCOGENE NEU,PROTO - ONCOGENE C - ERBB - 2,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2,P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? MURINE ADENOVIRUS 1 17 CKSSQPLEYSNNQWNYL 7 SWASTRK 10 CGQYSDYPNT 7 EYSNNQW 13 KLLISWASTRKSG 26 YCGQYSDYPNTFGAGTKLEIKQVQLV crystal 2.92A 21.10% scFv 16-JAN-19 20190116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN BCMA IN COMPLEX WITH UNIAB (TM) VH MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17; SYNONYM: B - CELL MATURATION PROTEIN; ENGINEERED: YES; OTHER_DETAILS: HUMAN B - CELL MATURATION ANTIGEN ? ? HOMO SAPIENS 0 N/A 0 N/A 0 N/A 5 SYGMS 17 GIRGSDGSTYYADSVKG 10 QGENDGPFDH crystal 2.60A 21.20% HC-dimer 18-JAN-19 20190118 ANTIVIRAL PROTEIN STRUCTURE OF A NEUTRALIZING ANTIBODY BOUND TO THE ZIKA ENVELOPE PROTEIN DOMAIN III MOLECULE: GENOME POLYPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.32A 16.90% FAB 07-FEB-19 20190207 ANTIVIRAL PROTEIN THE ASYMMETRIC - RECONSTRUCTED CRYO - EM STRUCTURE OF ZIKA VIRUS - FABZK2B10 COMPLEX MOLECULE: STRUTURAL PROTEIN M; EC: 3.4.21.91,3.6.1.15,3.6.4.13,2.1.1.56,2.1.1.57,2.7.7.48; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A FAB 08-FEB-19 20190208 VIRUS THE SYMMETRIC - RECONSTRUCTED CRYO - EM STRUCTURE OF ZIKA VIRUS - FABZK2B10 COMPLEX MOLECULE: STRUTURAL PROTEIN M; EC: 3.4.21.91,3.6.1.15,3.6.4.13,2.1.1.56,2.1.1.57,2.7.7.48; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A FAB 08-FEB-19 20190208 MEMBRANE PROTEIN / IMMUNE SYSTEM LAT1 - CD98HC COMPLEX BOUND TO MEM - 108 FAB MOLECULE: 4F2 CELL - SURFACE ANTIGEN HEAVY CHAIN; SYNONYM: GLYCOPROTEIN, 4F2HC,4F2 HEAVY CHAIN ANTIGEN,LYMPHOCYTE ACTIVATION ANTIGEN 4F2 LARGE SUBUNIT,SOLUTE CARRIER FAMILY 3 MEMBER 2; ENGINEERED: YES; ? ? MUS MUSCULUS 17 XXXXXXXXXXXXXXXXX 7 XXXXXXX 9 XXXXXXXXX 5 XXXXX 16 XXXXXXXXXXXXXXXX 10 XXXXXXXXXX ElectronMicroscopy N/A N/A FAB 13-MAR-19 20190313 MEMBRANE PROTEIN / IMMUNE SYSTEM CD98HC EXTRACELLULAR DOMAIN BOUND TO HBJ127 FAB AND MEM - 108 FAB MOLECULE: 4F2 CELL - SURFACE ANTIGEN HEAVY CHAIN; SYNONYM: 4F2HC,4F2 HEAVY CHAIN ANTIGEN,LYMPHOCYTE ACTIVATION ANTIGEN 4F2 LARGE SUBUNIT,SOLUTE CARRIER FAMILY 3 MEMBER 2; ENGINEERED: YES; ? ? MUS MUSCULUS 17 XXXXXXXXXXXXXXXXX 7 XXXXXXX 9 XXXXXXXXX 5 XXXXX 16 XXXXXXXXXXXXXXXX 10 XXXXXXXXXX ElectronMicroscopy N/A N/A FAB 13-MAR-19 20190313 AFB1 - BINDING PROTEIN SOLUTION STRUCTURE OF CAMELID NANOBODY NB11 AGAINST AFLATOXIN B1 ? ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 RSNAM 17 AAIRWSGGSTYYADSVK 14 AGVWRSSGWDTPDY NMR N/A N/A HC-dimer 14-MAY-19 20190514 VIRAL PROTEIN / IMMUNE SYSTEM CLEAVED EBOLA GP IN COMPLEX WITH A BROADLY NEUTRALIZING HUMAN ANTIBODY, ADI - 15946 MOLECULE: ENVELOPE GLYCOPROTEIN; SYNONYM: GP1,2,GP; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASHYISTYLN 7 AASNLQS 11 QQSYSTPGRYT 5 NAWMS 19 RIKSKTDGGTIDYAAPVKG 20 YTEDMRYFDWLLRGGETFDY crystal 4.10A 26.80% FAB 28-AUG-18 20180828 MEMBRANE PROTEIN HIV - 1 ENVELOPE GLYCOPROTEIN CLONE BG505 DELCT N332T IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODY FAB PGT151 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES ? ? HOMO SAPIENS 16 KSSESLRQSNGKTSLY 7 EVSNRFS 9 MQSKDFPLT 5 KYPMY 17 AISGDAWHVVYSNSVQG 26 MFQESGPPRLDRWSGRNYYYYSGMDV ElectronMicroscopy N/A N/A FAB 28-AUG-18 20180828 IMMUNE SYSTEM CRYO - EM STRUCTURE OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM FALCIPARUM WITH A VACCINE - ELICITED ANTIBODY REVEALS MATURATION OF INTER - ANTIBODY CONTACTS MOLECULE: PLASMODIUM FALCIPARUM RECOMBINANT SHORTENED CSP; SYNONYM: RSCSP; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGGSSNIGAGYDVH 7 GNINRPS 12 QSYDRRLSGSWV 5 NYGMH 17 IIWYDGSRNFYAASVEG 12 AAYYDTSGYGDY ElectronMicroscopy N/A N/A FAB 29-AUG-18 20180829 VIRAL PROTEIN CRYSTAL STRUCTURE OF THE B41 SOSIP.664 ENV TRIMER WITH PGT124 AND 35O22 FABS, IN P23 SPACE GROUP MOLECULE: TRANSMEMBRANE PROTEIN GP41; FRAGMENT: RESIDUES 516 - 668; SYNONYM: TM; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.53A 30.70% FAB 31-AUG-18 20180831 VIRAL PROTEIN CRYSTAL STRUCTURE OF THE B41 SOSIP.664 ENV TRIMER WITH PGT124 AND 35O22 FABS, IN P63 SPACE GROUP MOLECULE: TRANSMEMBRANE PROTEIN GP41; FRAGMENT: RESIDUES 516 - 668; SYNONYM: TM; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 24 DDTGTYFCAKGLLRDGSSTWLPYL crystal 3.82A 29.50% FAB 05-SEP-18 20180905 VIRAL PROTEIN CRYSTAL STRUCTURE OF THE CLADE B ISOLATE B41 MUTANT FUSION PEPTIDE (RESIDUES 512 - 521) IN COMPLEX WITH VRC34.01 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: RESIDUES 512 - 521; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQGVRNELA 7 YASTLQS 9 QHMSSYPLT 5 GNALH 17 WINPHSGDTTTSQKFQG 13 DKYYGNEAVGMDV crystal 1.97A 20.10% FAB 05-SEP-18 20180905 IMMUNE SYSTEM BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN ? ? ? HOMO SAPIENS 11 RAGQNINNYLN 7 AASNLQS 9 QQSHSTVRT 5 SYEIT 16 GITPIFETTYAQKFQG 17 DGVRYCGGGRCYNWFDP crystal 2.04A 18.30% ? 06-SEP-18 20180906 IMMUNE SYSTEM BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN ? ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASSLET 9 QHYNTYLFT 5 NYAIS 17 GMSPISNTPKYAQKFQG 18 DLLKYCGGGNCHSLLVDP crystal 1.36A 16.80% ? 06-SEP-18 20180906 IMMUNE SYSTEM BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN ? ? ? HOMO SAPIENS 11 RASQSVSSNLA 7 GASTRAT 9 QQYYRSPLT 5 NYALN 17 GVVPLFGTTRNAQKFQG 18 SVTPRYCGGGFCYGEFDY crystal 2.90A 22.30% ? 06-SEP-18 20180906 IMMUNE SYSTEM BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN ? ? ? HOMO SAPIENS 13 SGSSSNIGSNYVY 7 GNNQRPS 12 AAWDDSLSGPWV 5 SHGIS 17 WISVYNGYTNYAQNLQG 9 ASQIRGVDY crystal 1.41A 17.60% ? 06-SEP-18 20180906 IMMUNE SYSTEM BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN MOLECULE: E2 GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASSLET 9 QHYNTYLFT 5 NYAIS 17 GMSPISNTPKYAQKFQG 18 DLLKYCGGGNCHSLLVDP crystal 1.99A 18.80% ? 06-SEP-18 20180906 IMMUNE SYSTEM BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN MOLECULE: E2 GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RAGQNINNYLN 7 AASNLQS 9 QQSHSTVRT 5 SYEIT 16 GITPIFETTYAQKFQG 17 DGVRYCGGGRCYNWFDP crystal 2.90A 21.10% ? 06-SEP-18 20180906 IMMUNE SYSTEM BROADLY NEUTRALIZING ANTIBODIES AGAINST HCV USE A CDRH3 DISULFIDE MOTIF TO RECOGNIZE AN E2 GLYCOPROTEIN SITE THAT CAN BE TARGETED FOR VACCINE DESIGN MOLECULE: E2 GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 13 SGSSSNIGSNYVY 7 GNNQRPS 12 AAWDDSLSGPWV 5 SYEIT 16 GITPIFETTYAQKFQG 17 DGVRYCGGGRCYNWFDP crystal 2.80A 20.20% ? 06-SEP-18 20180906 IMMUNE SYSTEM STRUCTURE OF HERCEPTIN FAB WITHOUT ANTIGEN ? ? ? HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 6 WYAMDY crystal 2.80A 25.40% FAB 17-SEP-18 20180917 IMMUNE SYSTEM CRYO - EM STRUCTURE OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM FALCIPARUM WITH A VACCINE - ELICITED ANTIBODY REVEALS MATURATION OF INTER - ANTIBODY CONTACTS MOLECULE: CIRCUMSPOROZOITE PROTEIN; FRAGMENT: SHORTENED CONSTRUCT; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGGSSNIGAGYDVH 7 GNINRPS 12 QSYDRRLSGSWV 5 NYGMH 17 IIWYDGSRNFYAASVEG 12 AAYYDTSGYGDY ElectronMicroscopy N/A N/A FAB 17-SEP-18 20180917 IMMUNE SYSTEM STRUCTURE OF THE HUMAN 4 - 1BB / URELUMAB FAB COMPLEX MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9; SYNONYM: 4 - 1BB LIGAND RECEPTOR,CDW137,T - CELL ANTIGEN 4 - 1BB HOMOLOG,T - CELL ANTIGEN ILA; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 11 QQRSNWPPALT 5 GYYWS 16 EINHGGYVTYNPSLES 13 DYGPGNYDWYFDL crystal 2.80A 20.10% FAB 18-SEP-18 20180918 IMMUNE SYSTEM STRUCTURE OF THE HUMAN 4 - 1BB / UTOMILUMAB FAB COMPLEX MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9; SYNONYM: 4 - 1BB LIGAND RECEPTOR,CDW137,T - CELL ANTIGEN 4 - 1BB HOMOLOG,T - CELL ANTIGEN ILA; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 11 SGDNIGDQYAH 7 QDKNRPS 11 ATYTGFGSLAV 5 TYWIS 17 KIYPGDSYTNYSPSFQG 7 GYGIFDY crystal 2.72A 24.00% FAB 19-SEP-18 20180919 VIRUS / IMMUNE SYSTEM CRYO - EM STRUCTURE OF THE ZIKV VIRION IN COMPLEX WITH FAB FRAGMENTS OF THE POTENTLY NEUTRALIZING HUMAN MONOCLONAL ANTIBODY ZIKV - 195 MOLECULE: M PROTEIN; FRAGMENT: UNP RESIDUES 216 - 290; ? ? HOMO SAPIENS 13 SGSSSNIGNNAVN 7 YDDLLPS 11 AAWDDSLTRYV 5 SSAMH 17 VISYDGSNKYYGDSVKG 19 DRDAYNTVGYFAYYYGMDV ElectronMicroscopy N/A N/A FAB 19-SEP-18 20180919 VIRAL PROTEIN / IMMUNE SYSTEM CRYO - EM STRUCTURE OF HUMAN PARAINFLUENZA VIRUS TYPE 3 (HPIV3) IN COMPLEX WITH ANTIBODY PIA174 MOLECULE: FUSION GLYCOPROTEIN F0; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQAIANYLA 7 AASTLQS 9 HQYNTYPIT 5 SYYWS 16 NIYYSGTTKYNPSLKS 13 QVKSGWFVQPFDY ElectronMicroscopy N/A N/A FAB 24-SEP-18 20180924 VIRAL PROTEIN CRYSTAL STRUCTURE OF HEMAGGLUTININ FROM H1N1 INFLUENZA A VIRUS A / DENVER / 57 BOUND TO THE C05 ANTIBODY MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIRKFLN 7 DASNLQR 9 QQYDGLPFT 7 ESTLSYY 17 WLSIINAGGGDIDYADS 26 CAKHMSMQQVVSAGWERADLVGDAFD crystal 2.92A 20.50% FAB 27-SEP-18 20180927 TRANSFERASE STRUCTURE OF THIOESTERASE FROM DEBS WITH A THIOESTERASE - SPECIFIC ANTIBODY MOLECULE: 6 - DEOXYERYTHRONOLIDE - B SYNTHASE ERYA3, MODULES 5 AND 6; SYNONYM: DEBS 3,6 - DEOXYERYTHRONOLIDE B SYNTHASE III,ERYTHRONOLIDE SYNTHASE,ORF C; EC: 2.3.1.94; ENGINEERED: YES; ? ? HOMO SAPIENS 16 CRSSQSLLHSNGYNYL 7 YLGSNRA 10 CMQGTHWPRT 5 GYYWS 16 EINHSGSTNYNPSLKS 12 GLGYSGSYYAPN crystal 2.45A 17.80% FAB 27-SEP-18 20180927 VIRAL PROTEIN / IMMUNE SYSTEM H7 HA0 IN COMPLEX WITH FV FROM H7.5 IGG MOLECULE: HEMAGGLUTININ HA1 CHAIN; ENGINEERED: YES; ? IGG HOMO SAPIENS 11 RPSQSISTFLN 7 DASSLQS 9 QQSFSTPYT 5 RYYFH 17 IINPNGGGTSYAQKFGD 15 DMPYYHDSGGPLFDL ElectronMicroscopy N/A N/A FV 27-SEP-18 20180927 VIRAL PROTEIN CRYO - EM STRUCTURE OF BG505.SOSIP.664 IN COMPLEX WITH BF520.1 ANTIGEN BINDING FRAGMENT MOLECULE: ENVELOPE GLYCOPROTEIN GP41; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? ElectronMicroscopy N/A N/A scFv 01-OCT-18 20181001 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 + MAN8 RE - REFINEMENT ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.76A 22.00% FAB 01-OCT-18 20181001 IMMUNE SYSTEM ANTI - HIV - 1 FAB FAB 2G12 + MAN4 RE - REFINEMENT ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.00A 20.80% FAB 18-OCT-18 20181018 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR BMS - 378806 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 2.9 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.34A 23.50% FV 19-OCT-18 20181019 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR COMPOUND 484 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.0 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.50A 22.50% FV 20-OCT-18 20181020 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VRC42.01 FAB IN COMPLEX WITH T117 - F MPER SCAFFOLD MOLECULE: VRC42 EPITOPE T117 - F SCAFFOLD; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQNVRNSNLA 7 GASSRAS 9 QQYGGSFGT 5 TYTLS 17 GIIPLLGLPNYAPKFQG 15 EGAGWFGKPVGAMGY crystal 2.63A 22.60% FAB 21-OCT-18 20181021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VRC42.04 FAB IN COMPLEX WITH GP41 PEPTIDE MOLECULE: RV217 FOUNDER VIRUS GP41 PEPTIDE; SYNONYM: ENV POLYPROTEIN, ENVELOPE GLYCOPROTEIN GP160; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASETIRNNNLA 7 GASSTAT 9 QQYYKPPGT 5 TLTLT 17 GIIPLLSLPNYTQKFQG 15 EASGWFDKPLGAMGV crystal 2.04A 20.00% FAB 21-OCT-18 20181021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VRC42.N1 FAB IN COMPLEX WITH T117 - F MPER SCAFFOLD MOLECULE: VRC42 EPITOPE T117 - F SCAFFOLD; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVGSSYFA 7 GASTRAT 9 QQFDKSHVT 5 DYTLS 17 SIVPLLNLVNYAQRFQG 18 EGAEGWGWFAKPVGALGV crystal 2.70A 20.90% FAB 21-OCT-18 20181021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VRC43.01 FAB ? ? ? HOMO SAPIENS 14 ASSAGAVTSGHCPS 7 CTNNRQS 9 LVQYSGVWV 6 SSNWWN 16 EIYHSGTVTYNPSLKT 19 RWDSSGWFSRHSYDYAVDV crystal 1.80A 21.10% FAB 21-OCT-18 20181021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VRC43.03 FAB ? ? ? HOMO SAPIENS 14 ASSAGAVTSDFSPN 7 NTDKRHS 9 LVHYRGAWV 6 SSNWWN 16 EIYHDGSVSRNPFLQS 19 RWDSSGWITRHTYDYGVDV crystal 2.44A 24.50% FAB 21-OCT-18 20181021 IMMUNE SYSTEM CRYSTAL STRUCTURE OF VRC46.01 FAB IN COMPLEX WITH GP41 PEPTIDE MOLECULE: RV217 FOUNDER VIRUS GP41 PEPTIDE; ENGINEERED: YES ? ? HOMO SAPIENS 11 RSSQSISNYLN 7 AASSLQS 9 QQSYSSPYT 5 TYTFS 17 GILPLLNIANYAQKFQG 14 HSNSWFSPKWYFDV crystal 1.70A 23.60% FAB 21-OCT-18 20181021 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 + MAN7 RE - REFINEMENT ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.33A 20.30% FAB 22-OCT-18 20181022 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR BMS - 814508 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.2 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.55A 23.20% FV 22-OCT-18 20181022 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR BMS - 818251 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.1 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.50A 22.50% ? 22-OCT-18 20181022 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR BMS - 386150 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.5 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.99A 22.10% FV 22-OCT-18 20181022 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 + MAN5 RE - REFINEMENT ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.50A 24.70% FAB 22-OCT-18 20181022 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 B41 SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.4 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.91A 25.50% FV 23-OCT-18 20181023 IMMUNE SYSTEM / INHIBITOR CRYSTAL STRUCTURE OF HIV - 1 B41 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV - 1 ENTRY INHIBITOR BMS - 386150 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.8 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP160; FRAGMENT: GP41; SYNONYM: ENV POLYPROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.95A 23.30% FV 23-OCT-18 20181023 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF CHIMERIC EASTERN EQUINE ENCEPHALITIS VIRUS WITH FAB OF EEEV - 42 ANTIBODY MOLECULE: E2; FRAGMENT: ECTODOMAIN (UNP RESIDUES 325 - 801); ? ? MUS MUSCULUS 14 RSNIGAVTSSNCAN 7 DTNNRRS 9 ALWYNNLWV 5 EYPML 17 LIYTNTGEPTYAEEFKG 8 DYFISLDY ElectronMicroscopy N/A N/A FAB 23-OCT-18 20181023 IMMUNE SYSTEM ANTI - PCSK9 FAB 6E2 BOUND TO THE N - TERMINAL PEPTIDE FROM PCSK9 (E32K) MOLECULE: PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9; FRAGMENT: N - TERMINAL PEPTIDE (UNP RESIDUES 32 - 53); SYNONYM: NEURAL APOPTOSIS - REGULATED CONVERTASE 1, NARC - 1, PROPROTEIN CONVERTASE 9, PC9, SUBTILISIN / KEXIN - LIKE PROTEASE PC9; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 MQHLEYPFT 5 KYWMN 18 QIRLKSDNYATYAESVKG 5 EIFVN crystal 2.10A 21.10% FAB 24-OCT-18 20181024 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF CHIMERIC EASTERN EQUINE ENCEPHALITIS VIRUS WITH FAB OF EEEV - 3 ANTIBODY MOLECULE: E2; FRAGMENT: ECTODOMAIN (UNP RESIDUES 325 - 744); ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSNIGAVTSSNCAN 7 DTNNRRS 9 ALWYNNLWV 5 EYPML 17 LIYTNTGEPTYAEEFKG 8 DYFISLDY ElectronMicroscopy N/A N/A FAB 29-OCT-18 20181029 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF CHIMERIC EASTERN EQUINE ENCEPHALITIS VIRUS WITH FAB OF EEEV - 5 ANTIBODY MOLECULE: E2; FRAGMENT: ECTODOMAIN (UNP RESIDUES 325 - 744); ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSNIGAVTSSNCAN 7 DTNNRRS 9 ALWYNNLWV 5 EYPML 17 LIYTNTGEPTYAEEFKG 8 DYFISLDY ElectronMicroscopy N/A N/A FAB 29-OCT-18 20181029 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF CHIMERIC EASTERN EQUINE ENCEPHALITIS VIRUS WITH FAB OF EEEV - 58 ANTIBODY MOLECULE: E2; FRAGMENT: ECTODOMAIN (UNP RESIDUES 325 - 744); ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSNIGAVTSSNCAN 7 DTNNRRS 9 ALWYNNLWV 5 EYPML 17 LIYTNTGEPTYAEEFKG 8 DYFISLDY ElectronMicroscopy N/A N/A FAB 30-OCT-18 20181030 VIRUS / IMMUNE SYSTEM CRYOEM STRUCTURE OF CHIMERIC EASTERN EQUINE ENCEPHALITIS VIRUS WITH FAB OF EEEV - 69 ANTIBODY MOLECULE: E2; FRAGMENT: ECTODOMAIN (UNP RESIDUES 325 - 744); ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSNIGAVTSSNCAN 7 DTNNRRS 9 ALWYNNLWV 5 EYPML 17 LIYTNTGEPTYAEEFKG 8 DYFISLDY ElectronMicroscopy N/A N/A FAB 30-OCT-18 20181030 SIGNALING PROTEIN / HORMONE CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71 MOLECULE: ENDOLYSIN, BETA - 2 ADRENERGIC RECEPTOR CHIMERA; FRAGMENT: CHIMERA OF T4 LYSOZYME FUSED TO HUMAN BETA2 ADRENERGIC RECEPTOR (UNP RESIDUES 29 - 234,263 - 365); SYNONYM: LYSIS PROTEIN, LYSOZYME, MURAMIDASE,BETA - 2 ADRENORECEPTOR, BETA - 2 ADRENOCEPTOR; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYELR 16 GITTGGNTYYADSVKG 8 NWDLLSDY crystal 2.96A 20.70% HC-dimer 31-OCT-18 20181031 VIRAL PROTEIN / IMMUNE SYSTEM GERMLINE VRC01 ANTIBODY RECOGNITION OF A MODIFIED CLADE C HIV - 1 ENVELOPE TRIMER, 3 FABS BOUND, SHARPENED MAP MOLECULE: 426C DS - SOSIP D3; FRAGMENT: 426C GP120, BG505 GP41 CHIMERA; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYCQKFQG 12 GKNSDYNWDFQH ElectronMicroscopy N/A N/A FAB 02-NOV-18 20181102 VIRAL PROTEIN / IMMUNE SYSTEM GERMLINE VRC01 ANTIBODY RECOGNITION OF A MODIFIED CLADE C HIV - 1 ENVELOPE TRIMER, 2 FABS BOUND, SHARPENED MAP MOLECULE: 426C DS - SOSIP D3; FRAGMENT: 426C GP120, BG505 GP41 CHIMERA; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSVSSYLA 7 DASNRAT 5 QQYEF 5 GYYMH 17 WINPNSGGTNYCQKFQG 12 GKNSDYNWDFQH ElectronMicroscopy N/A N/A FAB 05-NOV-18 20181105 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 + MAN9 RE - REFINEMENT ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 3.00A 24.50% FAB 14-NOV-18 20181114 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 RE - REFINEMENT ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 2.20A 19.90% FAB 14-NOV-18 20181114 IMMUNE SYSTEM ANTI - HIV - 1 FAB 2G12 + MAN1 - 2 RE - REFINEMENT ? ? ? HOMO SAPIENS 11 RASQSIETWLA 7 KASTLKT 9 QHYAGYSAT 5 AHTMN 17 SISTSSTYRDYADAVKG 14 KGSDRLSDNDPFDA crystal 1.75A 20.80% FAB 14-NOV-18 20181114 MEMBRANE PROTEIN CRYOEM STRUCTURE OF NAV1.7 VSD2 (ACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2 MOLECULE: NAV1.7 VSD2 - NAVAB CHIMERA; SYNONYM: NEUROENDOCRINE SODIUM CHANNEL,HNE - NA,PERIPHERAL SODIUM CHANNEL 1,PN1,SODIUM CHANNEL PROTEIN TYPE IX SUBUNIT ALPHA,VOLTAGE - GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.7; ENGINEERED: YES; ? ? MUS MUSCULUS 12 SVSLSISSSNLF 7 GTSKLAS 9 QQWSSHSFT 5 NYAMS 17 TISNGGRYTYYPDSVKG 13 HLYRYDVGGALDY ElectronMicroscopy N/A N/A FAB 20-NOV-18 20181120 MEMBRANE PROTEIN CRYOEM STRUCTURE OF NAV1.7 VSD2 (DEACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2 MOLECULE: NAV1.7 VSD2 - NAVAB CHIMERA; SYNONYM: NEUROENDOCRINE SODIUM CHANNEL,HNE - NA,PERIPHERAL SODIUM CHANNEL 1,PN1,SODIUM CHANNEL PROTEIN TYPE IX SUBUNIT ALPHA,VOLTAGE - GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.7; ENGINEERED: YES; ? ? MUS MUSCULUS 12 SVSLSISSSNLF 7 GTSKLAS 9 QQWSSHSFT 5 NYAMS 17 TISNGGRYTYYPDSVKG 13 HLYRYDVGGALDY ElectronMicroscopy N/A N/A FAB 20-NOV-18 20181120 MEMBRANE PROTEIN METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN WITH NB43 MOLECULE: METABOTROPIC GLUTAMATE RECEPTOR 5; SYNONYM: MGLUR5; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 17 AISSSGGSTHYADSVKG 14 AMYGSRWPDWEYDY crystal 3.26A 20.10% HC-dimer 20-NOV-18 20181120 SIGNALING PROTEIN METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN IN COMPLEX WITH NB43 AND L - QUISQUALIC ACID MOLECULE: METABOTROPIC GLUTAMATE RECEPTOR 5; SYNONYM: MGLUR5; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 17 AISSSGGSTHYADSVKG 14 AMYGSRWPDWEYDY crystal 3.75A 26.80% HC-dimer 20-NOV-18 20181120 MEMBRANE PROTEIN METABOTROPIC GLUTAMATE RECEPTOR 5 BOUND TO L - QUISQUALATE AND NB43 MOLECULE: METABOTROPIC GLUTAMATE RECEPTOR 5; SYNONYM: MGLUR5; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYAMG 17 AISSSGGSTHYADSVKG 14 AMYGSRWPDWEYDY ElectronMicroscopy N/A N/A HC-dimer 20-NOV-18 20181120 VIRAL PROTEIN / IMMUNE SYSTEM BROADLY PROTECTIVE ANTIBODIES DIRECTED TO A SUBDOMINANT INFLUENZA HEMAGGLUTININ EPITOPE MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 10 ALWYSNHSWV 5 NYDMS 17 YISSGGDYIYYADTVKG 13 NYYYGSLPVWFAY crystal 3.50A 23.80% ? 21-NOV-18 20181121 VIRAL PROTEIN / IMMUNE SYSTEM BROADLY PROTECTIVE ANTIBODIES DIRECTED TO A SUBDOMINANT INFLUENZA HEMAGGLUTININ EPITOPE MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTKNRAP 9 ALWYSNHWV 5 SYDMS 17 YISSGGDYIYYADTVKG 10 VGEYDAWFAY crystal 3.00A 22.80% ? 21-NOV-18 20181121 VIRAL PROTEIN / IMMUNE SYSTEM BROADLY PROTECTIVE ANTIBODIES DIRECTED TO A SUBDOMINANT INFLUENZA HEMAGGLUTININ EPITOPE MOLECULE: HEMAGGLUTININ; ENGINEERED: YES; ? ? INFLUENZA A VIRUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWFSNHWV 5 GYDMS 17 YISSGGDYIYYADTVKG 13 DSDYYGSRVWFAY crystal 3.00A 25.70% ? 21-NOV-18 20181121 VIRAL PROTEIN / IMMUNE SYSTEM BDBV223 FAB BOUND TO SYNTHETIC PEPTIDE OF BUNDIBUGYO VIRUS GLYCOPROTEIN STALK MOLECULE: ENVELOPE GLYCOPROTEIN; FRAGMENT: UNP RESIDUES 620 - 635; SYNONYM: SPIKE GLYCOPROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 12 RASQSVPRNYIG 7 GASSRAA 9 HQYDRLPYT 5 TTYWN 16 EVNYSGNANYNPSLKG 14 RIRSHIAYSWKGDV crystal 3.68A 22.90% FAB 27-NOV-18 20181127 IMMUNE SYSTEM APO - BDBV223 FAB ? ? ? HOMO SAPIENS 12 RASQSVPRNYIG 7 GASSRAA 9 HQYDRLPYT 3 YWN 16 EVNYSGNANYNPSLKG 6 RIWKGD crystal 2.03A 23.50% FAB 28-NOV-18 20181128 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GII.4 2002 NOROVIRUS P DOMAIN IN COMPLEX WITH CROSS - REACTIVE HUMAN ANTIBODY A1227 MOLECULE: MAJOR CAPSID PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQSISSYLN 7 GASSLQS 9 QQSFSTPRT 5 NYAMT 17 SIGGSGGTTYYADSVKG 15 DKTRTLRLGYSGMDV crystal 2.58A 17.50% FAB 28-NOV-18 20181128 IMMUNE SYSTEM CRYSTAL STRUCTURE OF GII.4 2002 NOROVIRUS P DOMAIN IN COMPLEX WITH NEUTRALIZING HUMAN ANTIBODY A1431 MOLECULE: MAJOR CAPSID PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 KASRSISIYLA 7 DASYRAI 10 QHRSSWPALT 5 NHGMH 17 YISGSTGAIHYANSVKG 17 DGPRPDGTGYAGPSNDY crystal 3.10A 17.90% FAB 29-NOV-18 20181129 IMMUNE SYSTEM STRUCTURE OF A PEPTIDE - BASED PHOTO - AFFINITY CROSS - LINKER WITH HERCEPTIN FC ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; MOL_ID: 2; SYNTHETIC: YES; ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; ORGANISM_TAXID: 32630 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.58A 23.10% FC 04-DEC-18 20181204 VIRUS MERS - COV COMPLEX WITH HUMAN NEUTRALIZING LCA60 ANTIBODY FAB FRAGMENT (STATE 1) MOLECULE: SPIKE GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGTYDLVS 7 ADIKRPS 11 CLYAGSSTSVI 5 NVWMS 19 RIKRKSEGATTDYGAPVKG 16 LTRGGDVWSSSYYFDY ElectronMicroscopy N/A N/A FAB 06-DEC-18 20181206 VIRUS MERS - COV S COMPLEX WITH HUMAN NEUTRALIZING LCA60 ANTIBODY FAB FRAGMENT (STATE 2) MOLECULE: SPIKE GLYCOPROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 14 TGTSSDVGTYDLVS 7 ADIKRPS 11 CLYAGSSTSVI 5 NVWMS 19 RIKRKSEGATTDYGAPVKG 16 LTRGGDVWSSSYYFDY ElectronMicroscopy N/A N/A FAB 06-DEC-18 20181206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - MERS - COV HUMAN NEUTRALIZING LCA60 ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 14 TGTSSDVGTYDLVS 7 ADIKRPS 11 CLYAGSSTSVI 5 NVWMS 19 RIKRKSEGATTDYGAPVKG 7 LTRYFDY crystal 3.00A 23.10% FAB 06-DEC-18 20181206 VIRUS SARS - COV COMPLEX WITH HUMAN NEUTRALIZING S230 ANTIBODY FAB FRAGMENT (STATE 1) MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLVYSDGDTYLN 7 QVSNRDS 9 MQGSHWPPT 5 NYAMH 17 VITSDGRNKFYADSVKG 18 QRDNSRDYFPHYFHDMDV ElectronMicroscopy N/A N/A FAB 06-DEC-18 20181206 VIRUS SARS - COV COMPLEX WITH HUMAN NEUTRALIZING S230 ANTIBODY FAB FRAGMENT (STATE 2) MOLECULE: SPIKE GLYCOPROTEIN; SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 16 RSSQSLVYSDGDTYLN 7 QVSNRDS 9 MQGSHWPPT 5 NYAMH 17 VITSDGRNKFYADSVKG 18 QRDNSRDYFPHYFHDMDV ElectronMicroscopy N/A N/A FAB 06-DEC-18 20181206 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI - SARS - COV HUMAN NEUTRALIZING S230 ANTIBODY FAB FRAGMENT ? ? ? HOMO SAPIENS 16 RSSQSLVYSDGDTYLN 7 QVSNRDS 9 MQGSHWPPT 5 NYAMH 17 VITSDGRNKFYADSVKG 18 QRDNSRDYFPHYFHDMDV crystal 1.50A 13.10% FAB 06-DEC-18 20181206 SIGNALING PROTEIN CRYO - EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG - ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 07-DEC-18 20181207 SIGNALING PROTEIN CRYO - EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG - ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 07-DEC-18 20181207 SIGNALING PROTEIN CRYO - EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG - ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 07-DEC-18 20181207 IMMUNE SYSTEM AMC011 V4.2 SOSIP ENV TRIMER IN COMPLEX WITH FUSION PEPTIDE TARGETING ANTIBODY ACS202 FRAGMENT ANTIGEN BINDING MOLECULE: AMC011 V4.2 SOSIP GP41; ENGINEERED: YES; MUTATION: YES; KAPPA ? HOMO SAPIENS 11 QASQDIKKSLN 7 DASILQT 9 QEYENLQFT 5 DFGMH 18 VIGGGHGQHQSYSESVKG 22 DRLGRPWNIGGRLVYYYYGMDV ElectronMicroscopy N/A N/A ? 10-DEC-18 20181210 IMMUNE SYSTEM AMC011 V4.2 SOSIP ENV TRIMER IN COMPLEX WITH FUSION PEPTIDE TARGETING ANTIBODY VRC34 FRAGMENT ANTIGEN BINDING MOLECULE: HIV - 1 ENV AMC011 V4.2 SOSIP GP41; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASQGVRNELA 7 YASTLQS 9 QHMSSYPLT 5 GNALH 17 WINPHSGDTTTSQKFQG 13 DKYYGNEAVGMDV ElectronMicroscopy N/A N/A ? 10-DEC-18 20181210 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BROADLY NEUTRALIZING ANTIBODY ACS202 MOLECULE: HIV - 1 FUSION PEPTIDE (RESIDUES 512 - 520); ENGINEERED: YES; ? ? HOMO SAPIENS 11 QASQDIKKSLN 7 DASILQT 9 QEYENLQFT 5 DFGMH 18 VIGGGHGQHQSYSESVKG 22 DRLGRPWNIGGRLVYYYYGMDV crystal 2.76A 22.40% FAB 11-DEC-18 20181211 SIGNALING PROTEIN STRUCTURE OF BETA - KLOTHO IN COMPLEX WITH FGF19 C - TERMINAL PEPTIDE MOLECULE: FIBROBLAST GROWTH FACTOR 19; SYNONYM: FGF - 19; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYFMA 13 AVEYIFNTYYAKG 14 GVGASSVSESWYNY crystal 3.19A 28.20% HC-dimer 20-DEC-18 20181220 MEMBRANE PROTEIN A HIGH - RESOLUTION CRYO - ELECTRON MICROSCOPY STRUCTURE OF A CALCITONIN RECEPTOR - HETEROTRIMERIC GS PROTEIN COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 NYKMN 17 DISQSGASISYTGSVKG 19 CPAPFTRDCFDVTSTTYAY ElectronMicroscopy N/A N/A HC-dimer 02-JAN-19 20190102 MEMBRANE PROTEIN / IMMUNE SYSTEM STRUCTURE OF A COMPLEX MOLECULE: GLUTAMATE RECEPTOR 2; SYNONYM: GLUR - 2,AMPA - SELECTIVE GLUTAMATE RECEPTOR 2,GLUR - B,GLUR - K2, GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2; ? ? MUS MUSCULUS 11 RASQDISNYLS 7 YTSRLHS 9 QQGNTLPLT 5 NYGVH 16 VIWAGGSTNYNSALMS 11 EDYDYDWHFDV ElectronMicroscopy N/A N/A FV 03-JAN-19 20190103 MEMBRANE PROTEIN / IMMUNE SYSTEM STRUCTURE OF A COMPLEX MOLECULE: GLUTAMATE RECEPTOR 2; SYNONYM: GLUR - 2,AMPA - SELECTIVE GLUTAMATE RECEPTOR 2,GLUR - B,GLUR - K2, GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2; ? ? RATTUS NORVEGICUS 11 RASQDISNYLS 7 YTSRLHS 9 QQGNTLPLT 7 XXXXXXX 19 XXXXXXXXXXXXXXXXXXX 26 XXXXXXXXXXXXXXXXXXXXXXXXXX ElectronMicroscopy N/A N/A FAB 03-JAN-19 20190103 MEMBRANE PROTEIN STRUCTURE OF A COMPLEX MOLECULE: GLUTAMATE RECEPTOR 2; SYNONYM: GLUR - 2,AMPA - SELECTIVE GLUTAMATE RECEPTOR 2,GLUR - B,GLUR - K2, GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2; ? ? RATTUS NORVEGICUS 11 RASQDISNYLS 7 YTSRLHS 9 QQGNTLPLT 7 XXXXXXX 19 XXXXXXXXXXXXXXXXXXX 26 XXXXXXXXXXXXXXXXXXXXXXXXXX ElectronMicroscopy N/A N/A FV 03-JAN-19 20190103 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO N6 FR3 - 03 SCFV IN COMPLEX WITH CRYSTALLIZATION CHAPERONES 3H109L FAB AND 35O22 SCFV AT 3.2 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP41; FRAGMENT: ECTODOMAIN; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.74A 24.20% FV 10-JAN-19 20190110 VIRUS LIKE PARTICLE STRUCTURE OF PARVOVIRUS B19 DECORATED WITH FAB MOLECULES FROM A HUMAN ANTIBODY MOLECULE: VP2 OF B19 PARVOVIRUS; SYNONYM: VP1 PROTEIN; ENGINEERED: YES; ? ? HOMO SAPIENS 11 SGDNLGDKYVY 7 QDNKRPS 8 QTWDSTVV 7 SGGYYWS 16 HIYYSGTVYYNPSLRS 16 VRVDSVRGAGDNGFDP ElectronMicroscopy N/A N/A FAB 14-JAN-19 20190114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO VRC01 FR3 - 03 SCFV IN COMPLEX WITH CRYSTALLIZATION CHAPERONES 3H109L FAB AND 35O22 SCFV AT 3.5 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP41; FRAGMENT: GP41; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.76A 24.50% FV 14-JAN-19 20190114 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HIV - 1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO CH31 SCFV IN COMPLEX WITH CRYSTALLIZATION CHAPERONES 3H109L FAB AND 35O22 SCFV AT 3.1 ANGSTROM MOLECULE: ENVELOPE GLYCOPROTEIN GP41; FRAGMENT: GP41; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 14 TGPNSVCCSHKSIS 7 EDNERAP 10 CSYTHNSGCV 5 FYHIN 19 WISPYSGDKNLAPAFQDRV 26 TSDDTGTYFCAKGLLRDGSSTWLPYL crystal 2.60A 25.00% FV 15-JAN-19 20190115 IMMUNE SYSTEM AN SCFV DERIVED FROM IXEKIZUMAB ? ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 1.91A 18.20% scFv 16-JAN-19 20190116 IMMUNE SYSTEM A FAB DERIVED FROM IXEKIZUMAB ? ? ? HOMO SAPIENS 16 RSSRSLVHSRGNTYLH 7 KVSNRFI 9 SQSTHLPFT 5 DYHIH 17 VINPMYGTTDYNQRFKG 10 YDYFTGTGVY crystal 2.14A 24.00% FAB 16-JAN-19 20190116 VIRAL PROTEIN / IMMUNE SYSTEM CRYO - EM STRUCTURE OF T / F100 SOSIP.664 HIV - 1 ENV TRIMER IN COMPLEX WITH 8ANC195 FAB MOLECULE: T / F100 ENV GP41; FRAGMENT: UNP RESIDUES 513 - 665; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSITGNWVA 7 RGAALLG 9 QQYDTYPGT 6 GLYAVN 19 QIWRWKSSASHHFRGRVLI 20 TSTYDRWSGLHHDGVMAFSS ElectronMicroscopy N/A N/A FAB 21-JAN-19 20190121 IMMUNE SYSTEM CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING INFLUENZA A ANTIBODY 429 B01 IN COMPLEX WITH HEMAGGLUTININ HONG KONG 1968 MOLECULE: HEMAGGLUTININ HA2 CHAIN; FRAGMENT: RESIDUES 349 - 521; ENGINEERED: YES; ? ? HOMO SAPIENS 11 RASQGISYNLA 7 AASRLQS 9 QKYDSVPLT 5 TSVIH 17 VISYDGSNKYYADSVQG 16 GITVFGLLIINSAMDV crystal 2.95A 22.60% FAB 13-FEB-19 20190213 SIGNALING PROTEIN CRYSTAL STRUCTURE OF FRIZZLED 5 CRD IN COMPLEX WITH F2.I FAB MOLECULE: FRIZZLED - 5; SYNONYM: HFZ5,FZE5; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 8 QQGVYLFT 5 SSSIH 17 ATYSSFGSITYADSVKG 11 YHHPFGYALDY crystal 1.80A 19.80% FAB 26-FEB-19 20190226 SIGNALING PROTEIN CRYSTAL STRUCTURE OF FRIZZLED 7 CRD IN COMPLEX WITH F7.B FAB MOLECULE: FRIZZLED - 7; SYNONYM: HFZ7,FZE3; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 8 QQYYSLFT 5 SSSIH 17 YIYPSYDYTYYADSVKG 11 GYFYTWGGMDY crystal 2.10A 19.40% FAB 26-FEB-19 20190226 SIGNALING PROTEIN CRYSTAL STRUCTURE OF FRIZZLED 7 CRD IN COMPLEX WITH F6 FAB MOLECULE: FRIZZLED - 7; SYNONYM: HFZ7,FZE3; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSVSSAVA 7 SASSLYS 9 QQWAYGPFT 5 YYSMH 17 SIYSSYSYTSYADSVKG 11 SSPGADYGLDY crystal 2.50A 25.00% FAB 26-FEB-19 20190226 CELL INVASION STRUCTURE OF DBP IN COMPLEX WITH HUMAN NEUTRALIZING ANTIBODY 053054 MOLECULE: DUFFY BINDING SURFACE PROTEIN REGION II; ENGINEERED: YES; ? ? HOMO SAPIENS Numbering failed on one or both chains 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.90A 23.10% scFv 18-MAR-19 20190318 CELL INVASION STRUCTURE OF DBP IN COMPLEX WITH HUMAN NEUTRALIZING ANTIBODY 092096 MOLECULE: DUFFY BINDING SURFACE PROTEIN REGION II; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 13 KVSGYTLTELSMH 7 FDREDGE 15 DTAVYFCATDFGGSY 5 ELSMH 17 GFDREDGESIYAQKFQG 21 DFGGSYFYAFDIWGQGTMVTV crystal 3.50A 24.00% scFv 18-MAR-19 20190318 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FLUA - 20 FAB ? ? ? HOMO SAPIENS 11 RPSQNIRSFLN 7 AASNLQS 9 QQSYNTPPT 7 SDIYYWT 16 YIFYNGDTNYNPSLKS 16 GTEDLGYCSSGSCPNH crystal 1.73A 20.40% FAB 21-MAR-19 20190321 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FLUA - 20 FAB IN COMPLEX WITH THE HEAD DOMAIN OF H1 (A / SOLOMON ISLANDS / 3 / 2006) MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? HOMO SAPIENS 11 RPSQNIRSFLN 7 AASNLQS 9 QQSYNTPPT 7 SDIYYWT 16 YIFYNGDTNYNPSLKS 16 GTEDLGYCSSGSCPNH crystal 2.85A 23.80% FAB 21-MAR-19 20190321 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FLUA - 20 FAB IN COMPLEX WITH THE HEAD DOMAIN OF H3 (A / HONG KONG / 1 / 1968) MOLECULE: HEMAGGLUTININ; ENGINEERED: YES ? ? HOMO SAPIENS 11 RPSQNIRSFLN 7 AASNLQS 9 QQSYNTPPT 7 SDIYYWT 16 YIFYNGDTNYNPSLKS 16 GTEDLGYCSSGSCPNH crystal 2.10A 20.40% FAB 22-MAR-19 20190322 VIRAL PROTEIN / IMMUNE SYSTEM PREFUSION RSV F MONOMER BOUND BY NEUTRALIZING ANTIBODY CR9501 MOLECULE: FUSION GLYCOPROTEIN F0; SYNONYM: PROTEIN F, PREFUSION RSV F; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 QASQDISTYLN 7 GASNLET 9 QQYQYLPYT 7 SDNYYWT 16 HISYTGNTYYTPSLKS 15 CGAYVLISNCGWFDS crystal 3.30A 21.40% FAB 27-MAR-19 20190327 VIRAL PROTEIN / IMMUNE SYSTEM SPLAYED OPEN PREFUSION RSV F CAPTURED BY CR9501 AND MOTAVIZUMAB FABS MOLECULE: FUSION GLYCOPROTEIN F0,FIBRITIN; SYNONYM: PREFUSION RSV F, PROTEIN F,COLLAR PROTEIN,WHISKER ANTIGEN CONTROL PROTEIN; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSRVGYMH 7 DTSKLAS 9 FQGSGYPFT 7 TAGMSVG 16 DIWWDDKKHYNPSLKD 10 DMIFNFYFDV crystal 4.10A 26.40% FAB 27-MAR-19 20190327 TRANSFERASE / IMMUNE SYSTEM CRYO - EM STRUCTURE OF HER2 EXTRACELLULAR DOMAIN - TRASTUZUMAB FAB - PERTUZUMAB FAB COMPLEX MOLECULE: RECEPTOR TYROSINE - PROTEIN KINASE ERBB - 2; SYNONYM: METASTATIC LYMPH NODE GENE 19 PROTEIN,MLN 19,PROTO - ONCOGENE NEU,PROTO - ONCOGENE C - ERBB - 2,TYROSINE KINASE - TYPE CELL SURFACE RECEPTOR HER2,P185ERBB2; EC: 2.7.10.1; ENGINEERED: YES; ? ? HOMO SAPIENS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQRFKG 10 NLGPSFYFDY ElectronMicroscopy N/A N/A FAB 02-APR-19 20190402 SIGNALING PROTEIN MUSCARINIC ACETYLCHOLINE RECEPTOR 1 - G11 PROTEIN COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KLSCSASGFAFSSFGMH 7 ISSGSGT 15 DTAMYYCVRSIYYYG 5 SFGMH 17 YISSGSGTIYYADTVKG 26 SIYYYGSSPFDFWGQGTTLTVSSGGS ElectronMicroscopy N/A N/A scFv 09-APR-19 20190409 SIGNALING PROTEIN MUSCARINIC ACETYLCHOLINE RECEPTOR 2 - GO COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? MUS MUSCULUS 17 KLSCSASGFAFSSFGMH 7 ISSGSGT 15 DTAMYYCVRSIYYYG 5 SFGMH 17 YISSGSGTIYYADTVKG 26 SIYYYGSSPFDFWGQGTTLTVSSGGS ElectronMicroscopy N/A N/A scFv 09-APR-19 20190409 VIRAL PROTEIN / IMMUNE SYSTEM B41 SOSIP.664 IN COMPLEX WITH THE SILENT - FACE ANTIBODY SF12 AND V3 - TARGETING ANTIBODY 10 - 1074 MOLECULE: ENVELOPE GLYCOPROTEIN GP41; FRAGMENT: UNP RESIDUES 516 - 668; ENGINEERED: YES; ? ? HOMO SAPIENS 12 RASQSVSNVALA 7 EASTRAT 6 QLSGRR 5 LYYWS 17 FVYFDGSYGDYDPSLRS 21 LGPGGIFDRWTGHYGDKWLDP ElectronMicroscopy N/A N/A ? 14-APR-19 20190414 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SF12 FAB ? ? ? HOMO SAPIENS 12 RASQSVSNVALA 7 EASTRAT 6 QLSGRR 5 LYYWS 17 FVYFDGSYGDYDPSLRS 21 LGPGGIFDRWTGHYGDKWLDP crystal 3.20A 27.50% FAB 14-APR-19 20190414 VIRAL PROTEIN / IMMUNE SYSTEM MODIFIED BG505 SOSIP - BASED IMMUNOGEN RC1 IN COMPLEX WITH THE ELICITED V3 - GLYCAN PATCH BNAB 10 - 1074 MOLECULE: RC1 VARIANT OF HIV - 1 ENV GLYCOPROTEIN GP41; ENGINEERED: YES; ? ? HOMO SAPIENS 11 GRQALGSRAVQ 7 NNQDRPS 15 YYCHMWDSRSGFSWS 5 NYYWT 16 YISDRESATYNPSLNS 24 ARRGQRIYGVVSFGEFFYYYSMDV ElectronMicroscopy N/A N/A FAB 30-APR-19 20190430 VIRAL PROTEIN / IMMUNE SYSTEM MODIFIED BG505 SOSIP - BASED IMMUNOGEN RC1 IN COMPLEX WITH THE ELICITED V3 - GLYCAN PATCH ANTIBODY AB874NHP MOLECULE: RC1 VARIANT OF HIV - 1 ENV GLYCOPROTEIN GP120; ENGINEERED: YES; ? ? MACACA MULATTA 11 GGDNIGSEAVQ 7 DDSERPS 11 QVWDSSSDHPL 5 SYGMN 17 GINSGGGTKYYADSVKG 14 SPWGQSTSFEYFEF ElectronMicroscopy N/A N/A FAB 30-APR-19 20190430 VIRAL PROTEIN / IMMUNE SYSTEM MODIFIED BG505 SOSIP - BASED IMMUNOGEN RC1 IN COMPLEX WITH THE ELICITED V3 - GLYCAN PATCH ANTIBODY AB897NHP MOLECULE: RC1 VARIANT OF HIV - 1 ENV GLYCOPROTEIN GP120; ENGINEERED: YES; ? ? MACACA MULATTA 13 TGSTSNIGGFYVQ 7 ENNKRPS 11 QSYDNSLSAQV 6 SSNWWS 17 NIGGSSGNTYYNPSLKS 13 DSSGWPWDNRFDV ElectronMicroscopy N/A N/A FAB 30-APR-19 20190430 VIRAL PROTEIN / IMMUNE SYSTEM MODIFIED BG505 SOSIP - BASED IMMUNOGEN RC1 IN COMPLEX WITH THE ELICITED V3 - GLYCAN PATCH ANTIBODY AB275MUR MOLECULE: RC1 VARIANT OF HIV - 1 ENV GLYCOPROTEIN GP120; ENGINEERED: YES; ? ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPYT 5 RYGMS 17 TISSGGSYTYYPDSVKG 12 HGITTVGVAMDY ElectronMicroscopy N/A N/A FAB 30-APR-19 20190430 SIGNALING PROTEIN STRUCTURE OF HUMAN SMOOTHENED - GI COMPLEX MOLECULE: GUANINE NUCLEOTIDE - BINDING PROTEIN G (I) / G (S) / G (T) SUBUNIT BETA - 1; SYNONYM: TRANSDUCIN BETA CHAIN 1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQSVSSAVA 7 SASSLYS 9 QQSSSSLIT 5 YSSIH 17 SIYSYSGSTSYADSVKG 19 YPWYWWMEKPYLSLYGMDY ElectronMicroscopy N/A N/A FAB 02-MAY-19 20190502 VIRAL PROTEIN / IMMUNE SYSTEM SYNTHETIC FAB BOUND TO MARBURG VIRUS VP35 INTERFERON INHIBITORY DOMAIN MOLECULE: POLYMERASE COFACTOR VP35; FRAGMENT: INTERFERON INHIBITORY DOMAIN (UNP RESIDUES 204 - 329); SYNONYM: MARBURG VP35, MVP35; ENGINEERED: YES; ? ? SYNTHETIC CONSTRUCT 11 RASQSVSSAVA 7 SASSLYS 12 QQGYYYAYSLIT 5 YYYIH 17 SIYPYYGYTSYADSVKG 12 GSSWYGAHAFDY crystal 1.70A 19.80% FAB 02-MAY-19 20190502 MEMBRANE PROTEIN NANODISC RECONSTITUTED HUMAN - MOUSE CHIMERIC ABCB1 (ABCB1HM) - EQ MUTANT IN COMPLEX WITH UIC2 FAB AND ZOSUQUIDAR. MOLECULE: ABCB1HM - EQ; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 10 SQSTHIPPWT 5 NYYIH 17 FISCYNGATFYNQKFKG 13 LPIQFGNFYPMDY ElectronMicroscopy N/A N/A FAB 07-JAN-19 20190107 MEMBRANE PROTEIN NANODISC RECONSTITUTED HUMAN ABCB1 IN COMPLEX WITH UIC2 FAB AND TAXOL MOLECULE: MULTIDRUG RESISTANCE PROTEIN 1; SYNONYM: ATP - BINDING CASSETTE SUB - FAMILY B MEMBER 1,P - GLYCOPROTEIN 1; EC: 7.6.2.2; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 10 SQSTHIPPWT 5 NYYIH 17 FISCYNGATFYNQKFKG 13 LPIQFGNFYPMDY ElectronMicroscopy N/A N/A FAB 08-JAN-19 20190108 IMMUNE SYSTEM STRUCTURE OF BOVINE ANTI - RSV HYBRID FAB B4HC - B13LC MOLECULE: HEAVY CHAIN OF BOVINE ANTI - RSV B4; ENGINEERED: YES; ? ? BOS TAURUS 13 SGSSDNIGIFAVG 7 GNTKRPS 11 VCGESKSATPV 5 SYSVS 16 DASNGGIIYYNPALKS 21 CSVGDSGSYACTGRKGEYVDA crystal 2.15A 20.40% FAB 10-FEB-19 20190210 IMMUNE SYSTEM STRUCTURE OF BOVINE ANTI - RSV FAB B13 ? ? ? BOS TAURUS 13 SGSSDNIGIFAVG 7 GNTKRPS 11 VCGESKSATPV 5 DHNVG 16 VIYKEGDKDYNPALKS 25 LGCYFVEGVGYDCTYGLQHTTFHDA crystal 2.12A 23.70% FAB 10-FEB-19 20190210 IMMUNE SYSTEM STRUCTURE OF BOVINE ANTI - RSV FAB B4 MOLECULE: HEAVY CHAIN; ENGINEERED: YES; ? ? BOS TAURUS 13 SGSSSNIGRWGVN 7 YESSRPS 9 ATGDYNIAV 5 SYSVS 16 DASNGGIIYYNPALKS 21 CSVGDSGSYACTGRKGEYVDA crystal 1.89A 22.90% FAB 10-FEB-19 20190210 IMMUNE SYSTEM STRUCTURE OF BOVINE ANTI - RSV HYBRID FAB B13HC - B4LC MOLECULE: B13 HEAVY CHAIN; ENGINEERED: YES; ? ? BOS TAURUS 13 SGSSSNIGRWGVN 7 YESSRPS 9 ATGDYNIAV 5 DHNVG 16 VIYKEGDKDYNPALKS 25 LGCYFVEGVGYDCTYGLQHTTFHDA crystal 2.62A 22.10% FAB 10-FEB-19 20190210 BIOSYNTHETIC PROTEIN CAFFEINE RECOGNIZING NANOBODY MOLECULE: VHH; ENGINEERED: YES; ? ? CAMELIDAE 0 N/A 0 N/A 0 N/A 5 IYSMA 19 LATVGWSSGITYYMDSVKG 10 TRAYSVGYDY crystal 2.25A 19.60% HC-dimer 25-FEB-19 20190225 MEMBRANE PROTEIN STRUCTURE OF ATPGS - BOUND OUTWARD - FACING TM287 / 288 IN COMPLEX WITH SYBODY SB_TM35 MOLECULE: UNCHARACTERIZED ABC TRANSPORTER ATP - BINDING PROTEIN TM_0288; FRAGMENT: ABC TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 ISYLG 19 VAALWTKDGNTYYADSVKG 16 ADTGSDTPLWDWVYWY crystal 3.21A 24.40% HC-dimer 01-MAR-19 20190301 MEMBRANE PROTEIN STRUCTURE OF ATP - BOUND OUTWARD - FACING TM287 / 288 IN COMPLEX WITH SYBODY SB_TM35 MOLECULE: UNCHARACTERIZED ABC TRANSPORTER ATP - BINDING PROTEIN TM_0288; FRAGMENT: ABC TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? SYNTHETIC CONSTRUCT 0 N/A 0 N/A 0 N/A 5 ISYLG 19 VAALWTKDGNTYYADSVKG 16 ADTGSDTPLWDWVYWY crystal 3.12A 24.50% HC-dimer 01-MAR-19 20190301 MEMBRANE PROTEIN STRUCTURE OF ATPGS - BOUND OUTWARD - FACING TM287 / 288 IN COMPLEX WITH NANOBODY NB_TM1 MOLECULE: UNCHARACTERIZED ABC TRANSPORTER ATP - BINDING PROTEIN TM_0288; FRAGMENT: ABC TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 FFAVG 16 QMTSLRKINYADSVKG 7 SLPGLPY crystal 3.48A 26.90% HC-dimer 01-MAR-19 20190301 MEMBRANE PROTEIN STRUCTURE OF ATPGS - BOUND OUTWARD - FACING TM287 / 288 IN COMPLEX WITH NANOBODY NB_TM#2 MOLECULE: UNCHARACTERIZED ABC TRANSPORTER ATP - BINDING PROTEIN TM_0288; FRAGMENT: ABC TRANSPORTER; ENGINEERED: YES; MUTATION: YES; ? ? VICUGNA PACOS 0 N/A 0 N/A 0 N/A 5 YYAIG 17 CISNSGGSTKYADSVKG 20 DRGYSEYDLPCDLVIYGMDY crystal 4.23A 30.70% HC-dimer 01-MAR-19 20190301 IMMUNE SYSTEM THE STRUCTURE OF PLASMODIUM VIVAX DUFFY BINDING PROTEIN (PVDBP) BOUND TO HUMAN ANTIBODY DB9 MOLECULE: DUFFY RECEPTOR; SYNONYM: ERYTHROCYTE - BINDING PROTEIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASQSISSWLA 7 KASSLLS 9 QHYNTYPWT 7 SSTYYWG 16 SIYYSGSTYYNPSLKS 8 DGTGALDL crystal 3.04A 20.40% ? 18-MAR-19 20190318 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN MELANOMA - ASSOCIATED ANTIGEN B1 (MAGEB1) IN COMPLEX WITH NANOBODY MOLECULE: MELANOMA - ASSOCIATED ANTIGEN B1; SYNONYM: CANCER / TESTIS ANTIGEN 3.1,CT3.1,DSS - AHC CRITICAL INTERVAL MAGE SUPERFAMILY 10,DAM10,MAGE - B1 ANTIGEN,MAGE - XP ANTIGEN; ENGINEERED: YES ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYAMS 18 SINSSGGGIQSYADSVKG 24 AAWRVGTYDYRGQGTQVTVSSSKG crystal 2.68A 25.90% HC-dimer 29-MAR-19 20190329 BLOOD CLOTTING COAGULATION FACTOR XI CATALYTIC DOMAIN IN COMPLEX WITH FAB - PORTION OF MAA868 MOLECULE: COAGULATION FACTOR XI; SYNONYM: FXI,PLASMA THROMBOPLASTIN ANTECEDENT,PTA; EC: 3.4.21.27; ENGINEERED: YES; ? ? UNIDENTIFIED 13 SGSSSNIGSNDVS 7 KNYNRPS 11 SAWDQRQFDVV 5 TAAMS 17 GISGSGSSTYYADSVKG 13 ELSYLYSGYYFDY crystal 2.04A 22.00% FAB 02-APR-19 20190402 IMMUNE SYSTEM CRYSTAL STRUCTURE OF HUMAN IMMUNOGLOBULIN FRAGMENT FAB NEW REFINED AT 2.0 ANGSTROMS RESOLUTION ? LAMBDA IGG1 HOMO SAPIENS 14 TGSSSNIGAGHNVK 4 HNNA 9 QSYDRSLRV 5 DYYWT 16 YVFYTGTTLLDPSLRG 9 NLIAGGIDV crystal 2.00A 16.90% FAB 20-NOV-91 19911120 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF THE FAB FRAGMENT FROM THE HUMAN MYELOMA IMMUNOGLOBULIN IGG HIL AT 1.8 ANGSTROMS RESOLUTION ? LAMBDA IGG1 HOMO SAPIENS 11 SANALPNQYAY 7 KDTQRPS 9 QAWDNSASI 5 NYGMH 17 VIWYNGSRTYYGDSVKG 12 DPDILTAFSFDY crystal 1.80A 17.30% FAB 23-MAR-92 19920323