IMMUNOGLOBULIN 2E8 FAB FRAGMENT ? KAPPA IGG1 MUS MUSCULUS 11 KASQNVGTAVA 7 SASNRYT 9 QQYSSYPLT 5 DYYIH 17 WIDPEIGDTEYVPKFQG 11 GHDYDRGRFPY crystal 1.90A 22.10% FAB 14-MAR-98 19980314 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 5C8, FREE FAB ? ? IGG MUS MUSCULUS 12 TASSSVSSSNLH 7 STSNLAS 9 HQYHRSPYT 5 DTYMH 17 QIDPANGNTKYDPKFQG 10 DPPYYGHGDY crystal 2.50A 19.00% FAB 18-MAR-98 19980318 CATALYTIC ANTIBODY 29G11 : PHENYL [1-(1-N-SUCCINYLAMINO)PENTYL]PHOSPHONATE HAPTEN ? ? MUS MUSCULUS 11 KASQDIKKYIG 7 YTSTLLP 8 LQYYNLRT 5 DHVIH 17 YISPGNGDIKYNEKFKG 10 GYYGRSNVDY crystal 2.30A 20.30% FAB 05-DEC-97 19971205 COMPLEX (ANTIBODY/ANTIGEN) COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE MOLECULE: NEURAMINIDASE; FRAGMENT: RESIDUES 82 - 468; EC: 3.2.1.18; ? ? MUS MUSCULUS 11 RASQDISNYLN 7 YTSNLHS 9 QQDFTLPFT 5 NYNMY 17 IFYPGNGDTSYNQKFKD 13 SGGSYRYDGGFDY crystal 2.50A 20.00% FV 21-DEC-97 19971221 COMPLEX (IMMUNOGLOBULIN/HYDROLASE) HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES; MUTATION: YES KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.50A 20.30% FV 13-JAN-98 19980113 IMMUNOGLOBULIN CATALYSIS OF A DISFAVORED REACTION: AN ANTIBODY EXO DIELS- ALDERASE-TSA-INHIBITOR COMPLEX AT 1.95 A RESOLUTION AT 1.95 A RESOLUTION ? ? MUS MUSCULUS 16 RSSKSLLNSNGIIHMY 7 QMSKLAS 9 AQNLELPYT 5 NYWLG 17 DIYPGGVYTTNNEKFRG 10 AGGYYTGGDY crystal 1.95A 18.80% FAB 22-JAN-98 19980122 VIRAL PROTEIN/IMMUNE SYSTEM FAB FRAGMENT (ANTIBODY 8F5) COMPLEXED WITH PEPTIDE FROM HUMAN RHINOVIRUS (SEROTYPE 2) VIRAL CAPSID PROTEIN VP2 (RESIDUES 156-170) MOLECULE: HUMAN RHINOVIRUS CAPSID PROTEIN VP2; FRAGMENT: RESIDUES 156 - 170 ? IGG2 MUS MUSCULUS 17 KSSQSLLNSRTQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DIYIH 17 RLDPANGYTKYDPKFQG 9 YYSYYDMDY crystal 2.10A 17.10% FAB 23-JAN-98 19980123 IMMUNOGLOBULIN DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPPT 5 NYGMN 17 WINTYTGEPTYADDFKG 10 AERLRRTFDY crystal 2.10A 22.90% FAB 30-JAN-98 19980130 IMMUNOGLOBULIN DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE ? ? ? MUS MUSCULUS 16 RSSQSLLHSNGNTYLH 7 KVSNRFS 9 SQVTHVPPT 5 NYGMN 17 WINTYTGEPTYADDFKG 10 AERLRRTFDY crystal 2.40A 21.10% FAB 30-JAN-98 19980130 IMMUNOGLOBULIN FAB FRAGMENT OF A MONOCLONAL ANTI-E-SELECTIN ANTIBODY ? ? ? MUS MUSCULUS 17 KSSQSLLNSGAQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DAYMH 17 RIDSGSSNTNYDPTFKG 11 VGLSYWYAMDY crystal 2.80A 19.50% FAB 16-FEB-98 19980216 IMMUNOGLOBULIN FAB FRAGMENT OF MAB1-IA MONOCLONAL ANTIBODY TO HUMAN RHINOVIRUS 14 NIM-IA SITE ? ? IGG1 MUS MUSCULUS 10 SPSSSVSYMQ 7 STSNLAS 9 QQYSSHPLT 5 TYYMH 17 RVDPDNGGTSFNQKFKG 8 RDDYYFDF crystal 2.70A 16.90% FAB 03-MAR-98 19980303 IMMUNOGLOBULIN B1-8 FV FRAGMENT ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.10A 19.20% FV 03-MAR-98 19980303 IMMUNOGLOBULIN B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-3-NITROPHENYL) ACETATE COMPOUND A (4-HYDROXY-3-NITROPHENYL) ACETATE COMPOUND ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 1.80A 29.60% FV 03-MAR-98 19980303 IMMUNOGLOBULIN B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-5-IODO-3- NITROPHENYL) ACETATE COMPOUND A (4-HYDROXY-5-IODO-3- NITROPHENYL) ACETATE COMPOUND ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SYWMH 17 RIDPNSGGTKYNEKFKS 11 YDYYGSSYFDY crystal 2.00A 17.10% FV 03-MAR-98 19980303 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) VARIANT FOR CHAIN L GLU81->ASP AND CHAIN H LEU312->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 15.50% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) R96L DELETION MUTANT ON VARIANT FOR CHAIN L GLU81->ASP AND CHAIN H LEU312->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 8 QHFWSTPT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.00A 16.70% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) ENGINEERED MUTANT PRO95L->SER ON VARIANT CHAIN L GLU81- >ASP AND CHAIN H LEU312->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTSRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 17.40% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) HIGH AFFINITY EXPRESSED VARIANT CONTAINING SER26L->GLY, ILE29L->THR, GLU81L->ASP, THR97L->SER, PRO240H->LEU, ASP258H->ALA, LYS281H->GLU, ASN283H->ASP AND LEU312H->VAL ? KAPPA IGG1 MUS MUSCULUS 11 RAGGNTHNYLA 7 YTTTLAA 9 QHFWSTPRS 5 GYGVN 16 MIWGDGNTAYNSALKS 8 ERDYRLDY crystal 2.00A 17.80% FV 16-MAR-98 19980316 IMMUNOGLOBULIN FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) VARIANT CHAIN L GLU81->ASP ? KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.01A 17.00% FV 16-MAR-98 19980316 IMMUNOGLOBULIN IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME : LIGHT CHAIN DIMER WITH ASPARTAME LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 22.00% LC-dimer 26-MAR-98 19980326 COMPLEX(ANTIBODY/HIV-1 FRAGMENT) CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV- 1 MOLECULE: HIV-1 GP120 (MN ISOLATE); FRAGMENT: FRAGMENT (RESIDUES 308 - 332); ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 15 RASESVDSYGKSFMH 7 IASNLES 9 QQNNEDPPT 7 RTNYCWH 16 RICYEGSIYYSPSIKS 11 ENHMYETYFDV crystal 3.00A 21.00% FAB 10-FEB-94 19940210 IMMUNOGLOBULIN FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY A5B7 ? ? ? HOMO SAPIENS 10 RASSSVTYIH 7 ATSNLAS 9 QHWSSKPPT 5 DYYMN 19 FIGNKANGYTTEYSASVKG 10 DRGLRFYFDY crystal 2.50A 20.90% FAB 19-FEB-97 19970219 IMMUNOGLOBULIN IGG-FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY CTM01 ? ? IGG HOMO SAPIENS 16 RSSKSLLHSNGDTFLY 7 RMSNLAS 9 MQHLEYPFT 5 DYYIN 17 WIDPGSGNTKYNEKFKG 11 EKTTYYYAMDY crystal 2.80A 23.30% FAB 24-FEB-97 19970224 COMPLEX (IMMUNOGLOBULIN/AUTOANTIGEN) CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC MOLECULE: IGG4 REA FC; FRAGMENT: FC; LAMBDA IGM HOMO SAPIENS 11 GGNNIGSKSVH 7 DDSDRPP 11 QVWDSSSDHAV 5 DYAMH 17 GISWNTGTIIYADSVKG 14 TRSYVVAAEYYFHY crystal 3.15A 22.50% FAB 18-FEB-97 19970218 IMMUNOGLOBULIN IGG-FAB FRAGMENT OF MOUSE MONOCLONAL ANTIBODY CTM01 : EACH OF THE FOUR DOMAINS ADOPT THE IMMUNOGLOBULIN SUPERFAMILY FOLD; ? IGG MUS MUSCULUS 16 RSSKSLLHSNGDTFLY 7 RMSNLAS 9 MQHLEYPFT 5 DYYIN 17 WIDPGSGNTKYNEKFKG 11 EKTTYYYAMDY crystal 3.00A 21.00% FAB 06-MAR-97 19970306 VIRAL PROTEIN/IMMUNE SYSTEM HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 MOLECULE: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 CAPSID PROTEIN; FRAGMENT: AMINO-TERMINAL DOMAIN RESIDUES 1 - 151; SYNONYM: HIV-1 CA, HIV CA, HIV P24, P24; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RASESVDNYGISFMN 7 AASNLGS 9 QQSKEVPLT 5 SSWIH 17 EIHPNSGNTNYNEKFKG 11 WRYGSPYYFDY crystal 3.70A 21.70% FV 14-MAR-97 19970314 COMPLEX (IMMUNOGLOBULIN/TISSUE FACTOR) A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9) MOLECULE: TISSUE FACTOR; FRAGMENT: EXTRACELLULAR DOMAIN; SYNONYM: TF, THROMBOPLASTIN, COAGULATION FACTOR III; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDIRKYLN 7 YATSLAD 9 LQHGESPYT 5 DYYMH 17 LIDPENGNTIYDPKFQG 8 DNSYYFDY crystal 3.00A 21.70% FAB 10-APR-97 19970410 COMPLEX (ANTIBODY/PEPTIDE) HIV-1 V3 LOOP MIMIC MOLECULE: AIB142; ENGINEERED: YES; OTHER_DETAILS: THE PEPTIDE IS NUMBERED ACCORDING TO THE BH10 ISOLATE KAPPA IGG1 MUS MUSCULUS 15 RASESVDSYGKSFMH 7 IASNLES 9 QQNNEDPPT 7 RTNYCWH 16 RICYEGSIYYSPSIKS 11 ENHMYETYFDV crystal 2.80A 22.00% FAB 06-NOV-96 19961106 IMMUNOGLOBULIN ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A) FAB FROM MOUSE ? ? ? MUS MUSCULUS 12 SVSSSISSSNLH 7 GTSNLAS 9 QQWNSYPYT 5 NYWMS 19 EIRLNSDNFATHYAESVKG 10 RPLFYYAVDY crystal 2.90A 22.00% FAB 14-NOV-94 19941114 IMMUNOGLOBULIN IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY ? ? HOMO SAPIENS 11 RASQEISGYLS 7 AASTLDS 9 LQYASYPRT 5 DTYMH 17 RIDPANGNTKYDPKFQG 5 YYGIY crystal 2.10A 21.70% FAB 15-MAY-97 19970515 IMMUNOGLOBULIN SINGLE CHAIN FV OF C219 : LIGHT AND HEAVY CHAINS LINKED WITH A SYNTHETIC (GGGGS)3 LINKER; ? ? MUS MUSCULUS 17 KSSQSLLNSGNQKNYLT 7 WASTRES 9 QNDYSYPLT 5 DDFMH 17 RIDPANDNTKYAPKFQD 12 REVYSYYSPLDV crystal 2.36A 20.40% FV 23-JUL-97 19970723 IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF A HUMAN FAB WITH HIGH AFFINITY FOR TETANUS TOXOID ? ? ? HOMO SAPIENS 14 TGSNSNIGAGFTVH 7 ANTNRPS 10 QSYDSSLSAR 5 NYAIH 17 FISYDGSKNYYADSVKG 14 VLFQQLVLYAPFDI crystal 1.84A 0.00% FAB 30-JUL-97 19970730 COMPLEX (OXIDOREDUCTASE/ANTIBODY) STRUCTURE AT 2.7 ANGSTROM RESOLUTION OF THE PARACOCCUS DENITRIFICANS TWO-SUBUNIT CYTOCHROME C OXIDASE COMPLEXED WITH AN ANTIBODY FV FRAGMENT MOLECULE: CYTOCHROME C OXIDASE; SYNONYM: CYTOCHROME AA3, COMPLEX IV, FERROCYTOCHROME C, OXIDOREDUCTASE; EC: 1.9.3.1; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLGE 10 QHHYGTPPLT 5 SYTMS 17 SINNGGGRTYYPDTVKG 9 HEYYYAMDY crystal 2.70A 20.70% FV 08-AUG-97 19970808 IMMUNOGLOBULIN DISULFIDE-FREE IMMUNOGLOBULIN FRAGMENT ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 11 TVQASQDIIKH 7 IYEASNL 11 YCQQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 2.80A 28.00% LC-dimer 08-AUG-97 19970808 CATALYTIC ANTIBODY MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN ? ? ? HOMO SAPIENS 11 KASQDINSYLN 7 RTNRLVD 9 LQYDEFPYT 5 SFWIE 17 EILPGSGGTHYNEKFKG 11 GHSYYFYDGDY crystal 2.60A 20.00% FAB 20-OCT-97 19971020 IMMUNOGLOBULIN IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES ? ? IGG2 MUS MUSCULUS 16 RSSQSLVHSYGNTFLN 7 KVSNRFS 9 SQGTHVPYT 5 RFWMS 19 EIRLKSDNYATHYAESVKG 7 YFYSFSY crystal 2.15A 21.40% FAB 20-OCT-97 19971020 IMMUNOGLOBULIN ANTI TAQ FAB TP7 ? ? ? MUS MUSCULUS 10 SASSSVSYMY 7 DSTNLAS 9 QQWSTYPLT 6 SDYAWN 16 YITYSGTTDYNPSLKS 10 YYYGYWYFDV crystal 2.20A 19.60% FAB 13-NOV-97 19971113 IMMUNE SYSTEM STRUCTURAL COMPARISON OF AMYLOIDOGENIC LIGHT CHAIN DIMER IN TWO CRYSTAL FORMS WITH NONAMYLOIDOGENIC COUNTERPARTS MOLECULE: BENCE-JONES KAPPA I PROTEIN BRE; FRAGMENT: VARIABLE DOMAIN OF LIGHT CHAIN; SYNONYM: BENCE-JONES; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 QASQDISDYLI 7 DASTLET 9 QQYDDLPYT 0 N/A 0 N/A 0 N/A crystal 1.80A 22.60% LC-dimer 13-NOV-98 19981113 IMMUNE SYSTEM COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY ? ? ? 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 2.90A 18.80% FAB 01-DEC-98 19981201 ANTIBODY ENGINEERING COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY ? ? ? HOMO SAPIENS 11 KASENVDTYVS 7 GASNRYT 9 GQSYNYPFT 5 SSWIN 17 RIDPSDGEVHYNQDFKD 8 GFLPWFAD crystal 2.90A 19.30% FAB 22-DEC-98 19981222 IMMUNOGLOBULIN BENCE JONES PROTEIN DEL: AN ENTIRE IMMUNOGLOBULIN KAPPA LIGHT-CHAIN DIMER : IMMUNOGLOBULIN LIGHT-CHAIN DIMER KAPPA ? HOMO SAPIENS 11 QASQDISSYLN 7 AASSLET 9 QQYDSLPLT 0 N/A 0 N/A 0 N/A crystal 2.74A 20.70% LC-dimer 13-JAN-99 19990113 IMMUNOGLOBULIN 2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI-DINITROPHENYL- SPIN-LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN ? KAPPA IGG1 10 SASSSVYYMY 7 DTSNLAS 10 QQWSSYPPIT 6 SDYAWN 16 YMSYSGSTRYNPSLRS 6 GWPLAY crystal 2.90A 19.50% FAB 16-JAN-92 19920116 IMMUNOGLOBULIN THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2 ? KAPPA IGG2 17 KSSQSLLNSRTQKNYLT 7 WASTRES 9 QNNYNYPLT 5 DIYIH 17 RLDPANGYTKYDPKFQG 9 YYSYYDMDY crystal 2.80A 19.00% FAB 05-MAY-92 19920505 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF A CHIMERIC FAB' FRAGMENT OF AN ANTIBODY BINDING TUMOUR CELLS ? KAPPA IGG4 11 RASENIYSNLA 7 AATNLAD 9 QHFWGTPYT 5 DHAIH 17 YISPGNDDIKYNEKFKG 5 SYYGH crystal 3.10A 17.60% FAB 30-APR-92 19920430 ANTIBODY ANTIBODY TO CAMPATH-1H HUMANIZED FAB ? ? ? HOMO SAPIENS 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 3.25A 21.40% FAB 18-MAY-98 19980518 ANTIBODY CAMPATH-1G IGG2B RAT MONOCLONAL FAB ? ? IGG2 RATTUS RATTUS 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 2.60A 19.20% FAB 20-MAY-98 19980520 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI ? ? ? MUS MUSCULUS 16 RSSQSLVSNNRRNYLH 7 KVSNRFS 9 SQSSHVPLT 5 TYYMS 17 AINSDGEPIYYPDTLKG 10 LNYAVYGMDY crystal 2.10A 18.70% FV 27-MAY-97 19970527 COMPLEX (POLYMERASE/INHIBITOR) TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB TP7 ? ? MUS MUSCULUS 10 SASSSVSYMY 7 DSTNLAS 9 QQWSTYPLT 5 SDYAW 16 YITYSGTTDYNPSLKS 10 YYYGYWYFDV crystal 2.30A 18.90% FAB 02-JUN-98 19980602 COMPLEX (ANTIBODY/ANTIGEN) VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; FRAGMENT: RECEPTOR BINDING DOMAIN; SYNONYM: VEGF; ENGINEERED: YES ? ? MUS MUSCULUS 11 SASQDISNYLN 7 FTSSLHS 9 QQYSTVPWT 5 NYGMN 17 WINTYTGEPTYAADFKR 14 YPHYYGSSHWYFDV crystal 2.40A 19.60% FAB 30-JUN-98 19980630 BENCE-*JONES PROTEIN LOC (CRYSTALLIZED FROM AMMONIUM SULFATE) ? ? ? HUMAN (HOMO $SAPIENS) 13 SGSSSNIGENSVS 7 EDNSRAS 11 AAWDDSLDVAV 0 N/A 0 N/A 0 N/A crystal 3.00A 19.40% LC-dimer 11-MAR-91 19910311 IMMUNOGLOBULIN LOC NAKS, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN NAKSO4 MOLECULE: LOC - LAMBDA 1 TYPE LIGHT-CHAIN DIMER; SYNONYM: BENCE-JONES PROTEIN; OTHER_DETAILS: CRYSTALLIZED IN NA/K SO4 LAMBDA ? HOMO SAPIENS 13 SGSSSNIGENSVT 7 EDNSRAS 11 AAWDDSLDVAV 0 N/A 0 N/A 0 N/A crystal 2.20A 15.80% LC-dimer 26-MAY-95 19950526 IMMUNE SYSTEM ANTI-P-GLYCOPROTEIN FAB MRK-16 ? ? ? MUS MUSCULUS 16 RSSQSIVHSTGNTYLE 7 KISNRFS 9 FQASHAPRT 5 SYTMS 17 TISSGGGNTYYPDSVKG 10 YYRYEAWFAS crystal 2.80A 20.90% FAB 16-JUL-98 19980716 IMMUNE SYSTEM IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX IMMUNE SYSTEM IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX ? ? MURINE 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPLT 5 SYGMS 17 AISGGGTYIHYPDSVKG 16 HPFYRYDGGNYYAMDH crystal 2.00A 15.20% FAB 15-APR-99 19990415 COMPLEX (ANTIBODY/PEPTIDE) ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-HOMOLOGOUS PEPTIDE MOLECULE: PEPTIDE; ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.60A 30.70% FAB 04-AUG-98 19980804 ANTIBODY/ANTIGEN STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME MOLECULE: BOBWHITE QUAIL LYSOZYME; ENGINEERED: YES ? ? MUS MUSCULUS 10 SASSSVNYMY 7 DTSKLAS 8 QQWGRNPT 5 DYWIE 17 EILPGSGSTNYHERFKG 7 GNYDFDG crystal 2.60A 19.10% FAB 03-FEB-95 19950203 IMMUNOGLOBULIN IMMUNOGLOBULIN LIGHT CHAIN PROTEIN MOLECULE: BENCE-JONES KAPPA I PROTEIN BRE; SYNONYM: BENCE-JONES; ENGINEERED: YES KAPPA ? HOMO SAPIENS 11 QASQDISDYLI 7 DASTLET 9 QQYDDLPYT 0 N/A 0 N/A 0 N/A crystal 2.00A 21.80% LC-dimer 19-JUL-95 19950719 COMPLEX (HUMANIZED ANTIBODY/HYDROLASE) HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME MOLECULE: LYSOZYME; SYNONYM: MURAMIDASE; EC: 3.2.1.17; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.70A 20.80% FV 16-SEP-98 19980916 HUMANIZED ANTIBODY HUMANIZED ANTI-LYSOZYME FV ? ? ? HOMO SAPIENS, MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.87A 22.00% FV 16-SEP-98 19980916 IMMUNE SYSTEM BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT ? KAPPA ? HOMO SAPIENS 11 TCQASQDIIKY 7 IYEASNL 11 YCQQYQSLPYT 0 N/A 0 N/A 0 N/A crystal 1.70A 18.20% LC-dimer 29-SEP-98 19980929 IMMUNE SYSTEM FAB FRAGMENT FROM MURINE ASCITES ? ? ? MUS MUSCULUS 11 RASQDIGNFLN 7 YTSRLQS 9 QQGKTLPYT 5 NFGMH 17 YISSGGSSINYADTVKG 13 GGTGTRSLYYFDY crystal 2.50A 16.20% FAB 06-NOV-98 19981106 HYDROLASE/IMMUNE SYSTEM COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A MOLECULE: PROTEIN (RNASE A); EC: 3.1.27.5; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 YIYMG 19 VAAMDSGGGGTLYADSVKG 12 GGYELRDRTYGQ crystal 2.80A 28.20% HC-dimer 03-NOV-98 19981103 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME; ? ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.30A 23.50% FV 15-JUL-99 19990715 IMMUNE SYSTEM INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE ? ? ? MUS MUSCULUS 11 HASQGISSNIG 7 HGTNLED 9 VQYVQFPFT 6 SDYAWN 16 YISYSGSTSYSPSLKS 12 SLTWLLRRKRSY crystal 2.60A 20.50% FAB 20-JUL-99 19990720 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN WITH ITS HAPTEN ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 FQSTHFFPT 5 NYGMN 17 WINPYTGESTFADDFKG 10 GTTIVRAMDY crystal 1.90A 0.00% FAB 22-JUL-99 19990722 IMMUNE SYSTEM DECARBOXYLASE CATALYTIC ANTIBODY 21D8 UNLIGANDED FORM : THE CONSTANT DOMAIN (RESIDUES 103-214) IS FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1- 102) IS FROM MURINE SOURCE; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RTSQEISGYLS 7 DATKLDS 9 LQYASFPRT 5 SYWMH 17 LIDPSNGRTNFNDKFKS 3 IAY crystal 2.10A 18.80% FAB 08-NOV-99 19991108 IMMUNE SYSTEM DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX : THE CONSTANT DOMAIN (RESIDUES 103-214) IS FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1- 102) IS FROM MURINE SOURCE; ? ? MUS MUSCULUS, HOMO SAPIENS 11 RTSQEISGYLS 7 DATKLDS 9 LQYASFPRT 5 SYWMH 17 LIDPSNGRTNFNDKFKS 3 IAY crystal 1.61A 18.80% FAB 09-NOV-99 19991109 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR ? ? ? RATTUS NORVEGICUS 11 QASQDINKYIA 7 YTSILVL 8 LQYGNLYT 5 TNGVS 16 AISSGGSPYYNSALKS 9 EDGWNYFDY crystal 2.40A 19.60% FAB 17-NOV-99 19991117 TRANSFERASE/IMMUNE SYSTEM/DNA CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE- PRIMER MOLECULE: HIV-1 REVERSE TRANSCRIPTASE (CHAIN A); SYNONYM: HIV-1 RT; EC: 2.7.7.49; ENGINEERED: YES; MUTATION: M184I; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.50A 26.20% FAB 03-AUG-99 19990803 IMMUNE SYSTEM/DNA AN AUTOANTIBODY TO SINGLE-STRANDED DNA: COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE-FAB COMPLEX MOLECULE: DNA (5'-D(*TP*TP*T)-3'); ENGINEERED: YES; ? ? 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPLT 5 TNAMN 19 RIRSKSNNYATYYADSVKD 10 DQTGTAWFAY crystal 2.66A 19.10% FAB 16-MAR-93 19930316 IMMUNE SYSTEM STRUCTURE OF HUMAN LAMDA-6 LIGHT CHAIN DIMER JTO ? LAMBDA ? ESCHERICHIA COLI 13 TRSSGNIDSNYVQ 7 EDNQRPS 11 YCQSYDARNVV 0 N/A 0 N/A 0 N/A crystal 1.90A 18.40% LC-dimer 05-MAR-99 19990305 ANTIBODY 1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN MOLECULE: PROTEIN (PEPTIDE ANTIGEN); ENGINEERED: YES; OTHER_DETAILS: SYNTHETIC PEPTIDE; ? ? ESCHERICHIA COLI 11 KASQNIDKYLN 7 NTNNLQT 9 LQHISRPRT 5 DFYMN 19 FIRDKAKGYTTEYNPSVKG 10 EGHTAAPFDY crystal 1.90A 22.00% FAB 12-MAR-99 19990312 CATALYTIC ANTIBODY CONVERGENCE OF CATALYTIC ANTIBODY AND TERPENE CYCLASE MECHANISMS: POLYENE CYCLIZATION DIRECTED BY CARBOCATION-PI INTERACTIONS ? ? ? MUS MUSCULUS 12 SASSSVSSNYVY 7 STSNLAS 9 LQWSSFPYT 6 SGYAWN 16 YIRYSGDTRYNPSLKS 7 GYGNSDY crystal 2.70A 16.50% FAB 24-MAR-99 19990324 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-RELATED PEPTIDE MOLECULE: PROTEIN (BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.65A 27.70% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 ? KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.80A 22.10% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED PEPTIDE MOLECULE: PROTEIN (ANTIGEN BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.75A 23.20% FAB 19-MAR-99 19990319 POLYSPECIFICITY ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED D-PEPTIDE MOLECULE: PROTEIN (ANTIGEN BOUND PEPTIDE); ENGINEERED: YES KAPPA ? MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.80A 23.70% FAB 19-MAR-99 19990319 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI ? ? ? MUS MUSCULUS 16 RSSQSLVSNNRRNYLH 7 KVSNRFS 9 SQSSHVPLT 5 TYYMS 17 AINSDGEPIYYPDTLKG 10 LNYAVYGMDY crystal 2.10A 17.80% FV 11-APR-97 19970411 IMMUNOGLOBULIN LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB ATION OF AN ANTI-SWEETENER FAB KAPPA IGG2 16 RPSQSLVHSNGNTYLH 7 RVSNRFS 9 SQGTHVPYT 5 EYWIE 17 EILPGSGRTNYREKFKG 7 GYSSMDY crystal 2.60A 21.80% FAB 06-OCT-93 19931006 IMMUNOGLOBULIN IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225 ; D1.3-E225 ? ? MUS MUSCULUS 11 KASQDVRIAVA 7 WASTRHT 9 QHCGSYPFT 5 NYWMH 17 NIYPGSGDSNYDEKFKS 8 GLAFYFDH crystal 2.50A 0.00% FAB 31-MAR-99 19990331 IMMUNOGLOBULIN ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, UNLIGANDED FORM ? KAPPA ? MUS MUSCULUS 17 KSSQNLLHSITRKNYLA 7 WASTRGS 8 KQSYNLYT 5 TDAMN 19 RIRSKGFNFATYYADSVRD 9 GRDGEAMDY crystal 2.50A 19.20% FAB 26-APR-99 19990426 IMMUNE SYSTEM ANTI HIV1 PROTEASE FAB MOLECULE: PROTEIN (IGG1 ANTIBODY 1696 (CONSTANT HEAVY CHAIN)); FRAGMENT: FAB; SYNONYM: IMMUNOGLOBULIN, IGG1 ? IGG1 MUS MUSCULUS 16 RSSQTIVHNNGNTYLE 7 KVSNRFS 9 FQGSHFPPT 5 DYSMH 17 WINTETDEPTFADDFKG 11 DRHDYGEIFTY crystal 3.00A 18.30% FAB 06-MAY-99 19990506 IMMUNOGLOBULIN ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7 ? ? ? MUS MUSCULUS 10 RASSSVTYIH 7 ATSNLAS 9 QHWSSKPPT 5 DYYMN 19 FIGNKANGYTTEYSASVKG 10 DRGLRFYFDY crystal 2.10A 21.20% FAB 01-MAY-96 19960501 IMMUNOGLOBULIN IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER : COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER; KAPPA IGG1 HOMO SAPIENS 16 RSSQIIVHNNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YISQGGDITDYPDTVKG 10 GLDDGAWFAY crystal 2.50A 23.80% FAB 15-MAR-95 19950315 IMMUNOGLOBULIN IGG FAB (IGG3, KAPPA) FRAGMENT (MBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER : COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER; KAPPA IGG MUS MUSCULUS 16 RSSQIIVHNNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMY 17 YISQGGDITDYPDTVKG 10 GLDDGAWFAY crystal 2.80A 19.70% FAB 15-MAR-95 19950315 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE CH3 DOMAIN FROM THE MAK33 ANTIBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.20A 19.60% FC 06-AUG-99 19990806 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 ? ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLI 7 LVSKRDS 10 WQGTHFPHTV 5 DYYIQ 17 WIDPENGNSEYAPRFQG 5 DLHDY crystal 2.00A 17.10% FAB 14-AUG-99 19990814 IMMUNE SYSTEM CATALYTIC ANTIBODY 7C8 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY 7C8 COMPLEX ? ? MUS MUSCULUS 11 RASQSVSNKLH 7 FASQSIP 9 HQTHGRPLT 5 SSYIN 17 WIYAGSGGTVYNQHFTD 9 YRYDEGFAY crystal 2.20A 21.10% FAB 20-AUG-99 19990820 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE MOLECULE: RECOGNITION PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 KSSQSLLDSDGKTYLI 7 LVSKRDS 10 WQGTHFPHTV 5 DYYIQ 17 WIDPENGNSEYAPRFQG 5 DLHDY crystal 2.90A 15.90% FAB 20-AUG-99 19990820 IMMUNE SYSTEM VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR; FRAGMENT: RECEPTOR BINDING FRAGMENT; ENGINEERED: YES; ? ? MUS MUSCULUS 11 SASQDISNYLN 7 FTSSLHS 9 QQYSTVPWT 5 HYGMN 17 WINTYTGEPTYAADFKR 14 YPYYYGTSHWYFDV crystal 2.40A 0.00% FAB 01-SEP-99 19990901 IMMUNE SYSTEM UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDINSYLN 7 RTNRLVD 9 LQYDEFPYT 5 SFWIE 17 EILPGSGGTHYNEKFKG 11 GHSYYFYDGDY crystal 2.80A 23.20% FAB 06-OCT-99 19991006 IMMUNE SYSTEM UNLIGANDED GERMLINE PRECURSOR OF AN OXY-COPE CATALYTIC ANTIBODY ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDINSYLS 7 RANRLVD 9 LQYDEFPYT 5 SYWIE 17 EILPGSGSTNYNEKFKG 11 GHSYYFYDGDY crystal 2.00A 21.60% FAB 07-OCT-99 19991007 IMMUNE SYSTEM CONFORMATION EFFECTS IN BIOLOGICAL CATALYSIS INTRODUCED BY OXY-COPE ANTIBODY MATURATION ? ? ? MUS MUSCULUS, HOMO SAPIENS 11 KASQDINSYLS 7 RANRLVD 9 LQYDEFPYT 5 SYWIE 17 EILPGSGSTNYNEKFKG 11 GHSYYFYDGDY crystal 2.00A 22.40% FAB 15-OCT-99 19991015 IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.80A 20.20% FAB 10-NOV-92 19921110 IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.70A 21.00% FAB 11-NOV-92 19921111 IMMUNOGLOBULIN MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY ? KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.70A 21.40% FAB 24-AUG-93 19930824 IMMUNOGLOBULIN MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY ? KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 3.00A 21.30% FAB 24-AUG-93 19930824 IMMUNOGLOBULIN MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY ? KAPPA IGG1 MUS MUSCULUS 16 RSSQSLIHSNGNTYLH 7 KVSNRFY 9 SQSSHVPPT 5 NYGVN 17 WINIYTGEPTYVDDFKG 10 GDYVNWYFDV crystal 2.70A 21.80% FAB 24-AUG-93 19930824 IMMUNOGLOBULIN MCG, A LAMBDA V TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN), CRYSTALLIZED FROM AMMONIUM SULFATE MOLECULE: MCG; SYNONYM: BENCE-JONES PROTEIN; OTHER_DETAILS: A LAMBDA V TYPE LIGHT-CHAIN DIMER LAMBDA ? HOMO SAPIENS 14 TGTSSNVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.30A 0.00% LC-dimer 16-OCT-95 19951016 IMMUNE SYSTEM CRYSTAL STRUCTURE AT 2.7A RESOLUTION OF A COMPLEX BETWEEN A STAPHYLOCOCCUS AUREUS DOMAIN AND A FAB FRAGMENT OF A HUMAN IGM ANTIBODY MOLECULE: IMMUNOGLOBULIN G BINDING PROTEIN A; FRAGMENT: RECOMBINANT DOMAIN D; ENGINEERED: YES ? IGM HOMO SAPIENS 11 RTSQSISSYLN 7 AASSLQS 9 QQSYSAPRT 5 GYGMH 17 LISYDESNKYYADSVKG 12 VKFYDPTAPNDY crystal 2.70A 21.70% FAB 15-NOV-99 19991115 IMMUNOGLOBULIN STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I ? KAPPA IGG1 HOMO SAPIENS 11 RASQSISRWLA 7 KASSLES 7 QQYNSYS 5 DYAMH 17 GISWDSSSIGYADSVKG 17 GRDYYDSGGYFTVAFDI crystal 2.70A 17.70% FAB 27-MAR-92 19920327 IMMUNE SYSTEM THE STRUCTURAL BASIS OF REPERTOIRE SHIFT IN AN IMMUNE RESPONSE TO PHOSPHOCHOLINE : COMBINED LIGHT AND HEAVY CHAIN VIA (G4S)3 LINKER; ? ? HOMO SAPIENS 14 RSSTGAVTTSNYAN 7 GTKHRTP 9 ALWYSNHWV 5 GYGVN 16 MIWGDGSTDYNSALKS 5 DYGPY crystal 2.35A 19.10% FV 08-DEC-99 19991208 IMMUNOGLOBULIN HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FV FRAGMENT FROM AN ANTI-DANSYL SWITCH VARIANT ANTIBODY IGG2A(S) CRYSTALLIZED AT PH 5.25 ? ? IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 9 SQSTHVPFT 5 DAWMD 19 EIRNKANNHATYYAESVKG 10 IYYHYPWFAY crystal 1.45A 18.30% FV 14-JUL-98 19980714 IMMUNE SYSTEM STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ ? KAPPA IGM HOMO SAPIENS 12 GASQSVSSNYLA 7 DASSRAT 9 QQYGSSPLT 5 DYYWS 16 EINHSGSTNYNPSLKS 12 PPHDTSGHYWNY crystal 2.28A 18.00% FAB 15-DEC-99 19991215 IMMUNE SYSTEM FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2 ? LAMBDA IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; MOL_ID: 2; SYNTHETIC: YES; OTHER_DETAILS: SELECTED BY PHAGE DISPLAY. 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.70A 19.40% FC 15-DEC-99 19991215 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB HGR-2 F6, A COMPETITIVE ANTAGONIST OF THE GLUCAGON RECEPTOR ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 TTSNLAS 9 QQRSTYPPT 5 SGYWN 16 YISYSGSTYYNPSLKS 14 PPGYYGSGPYAMDY crystal 2.10A 31.50% FAB 04-JAN-00 20000104 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF THE ANTI-LYSOZYME ANTIBODY HYHEL-63 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.00A 21.70% FAB 04-JAN-00 20000104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN UNLIGANDED (NATIVE) FV FROM A HUMAN IGM ANTI-PEPTIDE ANTIBODY ? ? IGM HOMO SAPIENS 11 RASQDIRNDLG 7 AASSLQS 8 LQQNSNWT 5 SYAMH 17 VISSDGGNKYYTDSVKG 14 GNPPYSSGWGGGDY crystal 2.60A 18.10% FV 04-JAN-00 20000104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI-LYSOZYME ANTIBODY ? ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 2.10A 22.50% FAB 04-JAN-00 20000104 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTI-LYSOZYME ANTIBODY HYHEL-63 ? ? ? MUS MUSCULUS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YISYSGSTYYHPSLKS 5 WGGDV crystal 1.80A 21.00% FAB 04-JAN-00 20000104 IMMUNOGLOBULIN THE CRYSTAL STRUCTURE OF THE DISULFIDE-STABILIZED FV FRAGMENT OF ANTICANCER ANTIBODY B1: CONFORMATIONAL INFLUENCE OF AN ENGINEERED DISULFIDE BOND ? ? ? MUS MUSCULUS 16 RSSQNLVHSDGKTYLH 7 KVSNRFS 9 SQSTHVPLT 5 DNYMY 17 TISDGGTYIDYSDSVKG 12 SPIYYDYAPFTY crystal 2.00A 18.20% FV 04-MAY-97 19970504 D1.3 BOUND TO ANTI-IDIOTOPIC ANTIBODY E5.2 E5.2 ANTI-IDIOTOPIC ANTIBODY KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.90A 19.40% FV 13-APR-96 19960413 E5.2 ANTI-IDIOTOPIC ANTIBODY BOUND TO D1.3 D1.3 ANTIBODY IDIOTOPE KAPPA IGG1 MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGNTLPWT 5 DTHMN 17 RIDPANGNIQYDPKFRG 13 KVIYYQGRGAMDY crystal 1.90A 19.40% FV 13-APR-96 19960413 IMMUNE SYSTEM CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR III COMPLEX ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; CELL: LEUKOCYTE; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3); EXPRESSION_SYSTEM_CELLULAR_LOCATION: INCLUSION BODIES; EXPRESSION_SYSTEM_PLASMID: PET21; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; SECRETION: BLOOD; OTHER_DETAILS: OBTAINED BY PLASMIN DIGESTION 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.20A 27.08% FC 07-JUL-00 20000707 IMMUNE SYSTEM CROSSREACTIVE BINDING OF A CIRCULARIZED PEPTIDE TO AN ANTI-TGFALPHA ANTIBODY FAB-FRAGMENT MOLECULE: CYCLIC PEPTIDE; KAPPA ? MUS MUSCULUS 11 RASQDISHYLN 7 YTSTLHS 9 QQGGALPFT 5 NYWMH 17 EILPSNGRTNYNEKFKT 5 SPSDY crystal 1.95A 26.90% FAB 12-JUL-00 20000712 IMMUNE SYSTEM CROSSREACTIVE BINDING OF A CIRCULARIZED PEPTIDE TO AN ANTI-TGFALPHA ANTIBODY FAB-FRAGMENT MOLECULE: CYCLIC PEPTIDE; KAPPA ? MUS MUSCULUS 11 RASQDISHYLN 7 YTSTLHS 9 QQGGALPFT 5 NYWMH 17 EILPSNGRTNYNEKFKT 5 SPSDY crystal 1.90A 31.10% FAB 12-JUL-00 20000712 HIV CAPSID PROTEIN (P24) CRYSTAL STRUCTURE OF HIV-1 CAPSID PROTEIN (P24) IN COMPLEX WITH FAB13B5 MOLECULE: CAPSID PROTEIN P24; FRAGMENT: GAG POLYPROTEIN RESIDUES 142-351; SYNONYM: CA; ENGINEERED: YES; MUTATION: YES; OTHER_DETAILS: HIS6 TAG AT N-TERM, PRO1 AND ILE2 DELETED, C-TERMINUS MODIFIED ? ? MUS MUSCULUS 10 SASSSVSYMH 7 EISKLAS 8 QQWNYPFT 5 SYTMH 17 YINPSSGYSNYNQKFKD 11 PVVRLGYNFDY crystal 3.00A 21.00% FAB 18-AUG-00 20000818 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF FAB13B5 AGAINST HIV-1 CAPSID PROTEIN P24 ? ? ? MUS MUSCULUS 10 SASSSVSYMH 7 EISKLAS 8 QQWNYPFT 5 SYTMH 17 YINPSSGYSNYNQKFKD 11 PVVRLGYNFDY crystal 1.80A 22.50% FAB 21-AUG-00 20000821 CATALYTIC ANTIBODY CRYSTAL STRUCTURE OF A CATALYTIC ANTIBODY WITH A SERINE PROTEASE ACTIVE SITE ? KAPPA IGG2 MUS MUSCULUS 11 KASQDIKKYIG 7 YTSTLLP 8 LQYYNLRT 5 DHAIH 17 YISPGNGDIKYNEKFKV 10 SYYGSSYVDY crystal 2.40A 18.60% FAB 10-AUG-94 19940810 IMMUNE SYSTEM M4L/Y(27D)D/T94H MUTANT OF LEN ? KAPPA ? HOMO SAPIENS 17 KSSQSVLDSSNSKNYLA 7 WASTRES 9 QQYYSHPYS 0 N/A 0 N/A 0 N/A crystal 1.50A 21.10% LC-dimer 01-FEB-00 20000201 IMMUNE SYSTEM M4L/Y(27D)D/Q89D/T94H MUTANT OF LEN ? KAPPA ? HOMO SAPIENS 17 KSSQSVLDSSNSKNYLA 7 WASTRES 9 DQYYSHPYS 0 N/A 0 N/A 0 N/A crystal 1.60A 19.40% LC-dimer 03-FEB-00 20000203 IMMUNE SYSTEM Q38D MUTANT OF LEN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PASK40 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 1.60A 23.00% LC-dimer 09-FEB-00 20000209 IMMUNE SYSTEM DOMAIN 4 OF THE BETA COMMON CHAIN IN COMPLEX WITH AN ANTIBODY MOLECULE: CYTOKINE RECEPTOR COMMON BETA CHAIN PRECURSOR; FRAGMENT: DOMAIN 4; ENGINEERED: YES; ? ? MUS MUSCULUS 15 RANESVYSYGDSFMH 7 LASNLAS 9 QQNNEDPWT 5 DYYMK 17 DINPSNGGTLYNQKFKG 10 GDGIHGGFAY crystal 2.80A 22.80% ? 15-FEB-00 20000215 IMMUNE SYSTEM 64M-2 ANTIBODY FAB COMPLEXED WITH D(5HT)(6-4)T MOLECULE: 5'-(D(5HT)P*(6-4)T)-3'; ENGINEERED: YES; OTHER_DETAILS: COMPLEX INVOLVES A C6-C4 BOND BETWEEN 5HT(1) AND T(2), A PHOTOPRODUCT LIGAND; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 8 FQGSLVPT 5 SFWMH 17 TIYPGNSDTSYNQKFKG 11 RSGYKYYALDY crystal 2.40A 19.20% FAB 21-FEB-00 20000221 IMMUNE SYSTEM FAB FRAGMENT OF NEUTRALISING MONOCLONAL ANTIBODY 4C4 COMPLEXED WITH G-H LOOP FROM FMDV. MOLECULE: FMDV PEPTIDE; FRAGMENT: G-H LOOP; ENGINEERED: YES ? IGG2 MUS MUSCULUS 15 RASESVDSYGNSFMH 7 RASNLES 9 QQSNEDPLT 5 SYTMS 17 TISSGGAYTYYPDSVKG 11 RAFDSDVGFAS crystal 2.30A 24.80% FAB 03-MAR-00 20000303 IMMUNE SYSTEM KAPPA-4 IMMUNOGLOBULIN VL, REC ? KAPPA ? HOMO SAPIENS 17 KSSQNLLDSSFDTNTLA 7 WASSRES 9 QQYYSTPPT 0 N/A 0 N/A 0 N/A crystal 1.90A 18.70% LC-dimer 06-MAR-00 20000306 IMMUNE SYSTEM FAB ANTIBODY FRAGMENT OF AN C60 ANTIFULLERENE ANTIBODY ? ? IGG MUS MUSCULUS 11 SASQDISNYLN 7 YTSSLRS 9 QQYSRLPFT 5 SSWMN 17 RIYPGNGNTNYNEKFKG 4 SSAY crystal 2.25A 18.00% FAB 17-MAR-00 20000317 VIRAL PROTEIN/IMMUNE SYSTEM INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY MOLECULE: HEMAGGLUTININ (HA1 CHAIN); FRAGMENT: BROMELAIN RELEASED FRAGMENT; OTHER_DETAILS: A RECOMBINANT INFLUENZA STRAIN CONTAINING A/AICHI/68 (H3N2) HEMAGGLUTININ; ? ? MUS MUSCULUS 10 SASSDISYMH 7 DTSKLAS 8 HQRSSYPT 5 TYFIE 17 EILPGSDNTNFNEKFKD 9 PTGRLWFSY crystal 2.80A 19.60% FAB 22-MAR-00 20000322 IMMUNE SYSTEM THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS ? ? ? MUS MUSCULUS 14 RSSTGAVTTSNYAI 7 GTNNRVP 9 ALWYSNHWV 7 TSGMGVG 16 DIWWNDKKYYNPSLKS 16 RTFSYYYGSSFYYFDN crystal 2.60A 19.80% FAB 13-APR-00 20000413 OXIDOREDUCTASE/ELECTRON TRANSPORT STRUCTURE OF THE YEAST CYTOCHROME BC1 COMPLEX CO- CRYSTALLIZED WITH AN ANTIBODY FV-FRAGMENT MOLECULE: UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN I; FRAGMENT: RESIDUES 24-457; EC: 1.10.2.2; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASQDINNFLN 7 YTSRLHA 9 QHHIKFPWT 6 SGYYWN 16 YISNVGDNNYNPSLKD 13 SEYYSVTGYAMDY crystal 2.30A 22.20% FV 12-MAY-00 20000512 IMMUNE SYSTEM F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY ? KAPPA ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 VASNLKS 9 QQSNEDPFT 5 DYYMK 17 DINPNNGGTGYNQKFKG 10 DYGSTYGFAY crystal 3.00A 18.40% FAB 18-MAY-00 20000518 IMMUNE SYSTEM STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05 ? ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.10A 0.00% HC-dimer 30-MAY-00 20000530 IMMUNE SYSTEM CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN. WITH ITS AMIDINIUM HAPTEN. ? ? MUS MUSCULUS 16 RSSQSIFHSDGKTYLE 7 KVSKRFS 9 FQGSHVPYT 5 DYNIH 17 YIVPYSGGTTFNQKFKG 6 DYDGVY crystal 1.87A 19.80% FAB 02-JUN-00 20000602 IMMUNE SYSTEM COMPLEX BETWEEN FV ANTIBODY FRAGMENT AND AN ANALOGUE OF THE MAIN IMMUNOGENIC REGION OF THE ACETYLCHOLINE RECEPTOR MOLECULE: ACETYLCHOLINE RECEPTOR ALPHA; FRAGMENT: MAIN IMMUNOGENIC REGION (91-100); ENGINEERED: YES; MUTATION: YES; ? ? RATTUS NORVEGICUS 0 N/A 0 N/A 0 N/A 5 SFSVS 16 RMWYDGYTAYNSALKS 26 DLYGGYPLGFWYFDFWGPGTMVTVSS NMR N/A N/A HC-dimer 06-JUN-00 20000606 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN WITH ANTIGEN ? ? MUS MUSCULUS 14 RSSTGTVTTSNYAN 7 ATNNRAA 9 ALWYSGHWV 5 TYDMS 17 FISSGGGRTSYPDTVKG 8 HFYAVLDY crystal 2.30A 26.10% FAB 10-JUN-00 20000610 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN WITH ANTIGEN ? ? MUS MUSCULUS 14 RSSTGTVTTSNYAN 7 ATNNRAA 9 ALWYSGHWV 5 TYDMS 17 FISSGGGRTSYPDTVKG 8 HFYAVLDY crystal 2.30A 25.00% FAB 10-JUN-00 20000610 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN WITH ANTIGEN ? ? MUS MUSCULUS 14 RSSTGTVTTSNYAN 7 ATNNRAA 9 ALWYSGHWV 5 TYDMS 17 FISSGGGRTSYPDTVKG 8 HFYAVLDY crystal 2.80A 35.20% FAB 10-JUN-00 20000610 VIRAL PROTEIN/IMMUNE SYSTEM IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 24-RESIDUE PEPTIDE (RESIDUES 308-333 OF HIV-1 GP120 (MN ISOLATE) WITH ALA TO AIB SUBSTITUTION AT POSITION 323 MOLECULE: PROTEIN (EXTERIOR MEMBRANE GLYCOPROTEIN(GP120)); FRAGMENT: RESIDUES 308-332 FROM HIV-1 GP120; SYNONYM: V3 LOOP; ENGINEERED: YES; MUTATION: YES ? IGG1 MUS MUSCULUS 15 KASQGVDFDGASFMN 7 AASTLES 9 QQSHEDPLT 6 SGYSWH 16 YIHYSAGTNYNPSLKS 17 EEAMPYGNQAYYYAMDC crystal 2.00A 19.60% FAB 21-OCT-98 19981021 IMMUNE SYSTEM STRUCTURE OF THE HUMAN IGE-FC BOUND TO ITS HIGH AFFINITY RECEPTOR FC(EPSILON)RI(ALPHA) ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_COMMON: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PVL1392; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_COMMON: HI-5 INSECT CELLS; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PVL1392 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.50A 25.40% FC 20-JUN-00 20000620 IMMUNE SYSTEM VARIABLE LIGHT CHAIN DIMER OF ANTI-FERRITIN ANTIBODY ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; ORGAN: SPLEEN; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PETVL 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPFT 0 N/A 0 N/A 0 N/A crystal 2.80A 19.10% LC-dimer 22-JUN-00 20000622 IMMUNE SYSTEM FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE ? ? ? MUS MUSCULUS 16 ESSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPRT 6 SDYAWN 16 YITYSGSTGYNPSLKS 9 YDDYTWFTY crystal 2.20A 17.10% FAB 05-JUL-00 20000705 IMMUNE SYSTEM FAB FRAGMENT OF MONOCLONAL ANTIBODY (LNKB-2) AGAINST HUMAN INTERLEUKIN-2 IN COMPLEX WITH ANTIGENIC PEPTIDE MOLECULE: ANTIGENIC NONAPEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 16 ESSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPRT 6 SDYAWN 16 YITYSGSTGYNPSLKS 9 YDDYTWFTY crystal 2.60A 16.50% FAB 06-JUL-00 20000706 IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY ? KAPPA IGG2 MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGSTLPRT 5 SYGVN 17 YINPGKGYLSYNEKFKG 15 SFYGGSDLAVYYFDS crystal 2.70A 18.90% FAB 27-MAY-92 19920527 COMPLEX (ANTIBODY/ANTIGEN) CRYSTAL STRUCTURE OF A CROSS-REACTION COMPLEX BETWEEN FAB F9.13.7 AND GUINEA-FOWL LYSOZYME MOLECULE: GUINEA FOWL LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? IGG1 MUS MUSCULUS 11 RASQDISNYLN 7 YTSRLHS 9 QQGYTLPYT 5 SYWMH 17 EIDPSDSYPNYNEKFKG 13 LYYYGTSYGVLDY crystal 3.00A 19.00% FAB 19-JAN-95 19950119 IMMUNOGLOBULIN CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF A HUMAN FC FRAGMENT AND ITS COMPLEX WITH FRAGMENT B OF PROTEIN A FROM STAPHYLOCOCCUS AUREUS AT 2.9-AND 2.8-ANGSTROMS RESOLUTION ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; TISSUE: SERUM 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.90A 0.00% FC 21-MAY-81 19810521 IMMUNOGLOBULIN CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF A HUMAN FC FRAGMENT AND ITS COMPLEX WITH FRAGMENT B OF PROTEIN A FROM STAPHYLOCOCCUS AUREUS AT 2.9-AND 2.8-ANGSTROMS RESOLUTION ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS SUBSP. AUREUS NCTC 8325; ORGANISM_TAXID: 93061; STRAIN: NCTC 8325; MOL_ID: 2; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 0.00% FC 21-MAY-81 19810521 COMPLEX (ANTIBODY/ANTIGEN) CRYSTAL STRUCTURE OF THE C2 FRAGMENT OF STREPTOCOCCAL PROTEIN G IN COMPLEX WITH THE FC DOMAIN OF HUMAN IGG ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; CELL_LINE: HYBRIDOMA; GENE: N-TERMINAL FRAGMENT OF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PEB2ZHIS GENE: N-TERMINAL FRAGMENT OF; MOL_ID: 2; ORGANISM_SCIENTIFIC: STREPTOCOCCUS; ORGANISM_TAXID: 1301; CELL_LINE: HYBRIDOMA; GENE: N-TERMINAL FRAGMENT OF; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562; EXPRESSION_SYSTEM_PLASMID: PEB2ZHIS GENE: N-TERMINAL FRAGMENT OF 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.20A 28.90% FC 17-JAN-95 19950117 COMPLEX (ANTIBODY-ANTIGEN) CRYSTALLOGRAPHIC REFINEMENT OF THE THREE-DIMENSIONAL STRUCTURE OF THE FAB D1.3-LYSOZYME COMPLEX AT 2.5- ANGSTROMS RESOLUTION MOLECULE: HEN EGG WHITE LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.50A 18.40% FAB 27-AUG-90 19900827 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING MOLECULE: VON WILLEBRAND FACTOR; FRAGMENT: COLLAGEN BINDING DOMAIN A3; ENGINEERED: YES; ? IGG MUS MUSCULUS 11 RASQDIGNYLN 7 YTSRLHS 9 QNGGTNPWT 5 TYGVS 16 VIWGDGNTTYHSALIS 7 NYYGMDY crystal 2.03A 22.70% FAB 21-JUL-00 20000721 IMMUNOGLOBULIN MONOCLONAL MURINE ANTIBODY 5G9-ANTI-HUMAN TISSUE FACTOR ? ? ? MUS MUSCULUS 11 KASQDIRKYLN 7 YATSLAD 9 LQHGESPYT 5 DYYMH 17 LIDPENGNTIYDPKFQG 8 DNSYYFDY crystal 2.50A 21.70% FAB 10-APR-97 19970410 FV FRAGMENT OF A HUMANIZED VERSION OF THE ANTI-CD18 ANTIBODY 'H52' (HUH52-AA FV) ? ? ? SYNTHETIC GENE EXPRESSED IN (ESCHERICHIA COLI) 11 RASQDINNYLN 7 YTSTLES 9 QQGNTLPPT 5 EYTMH 17 GINPKNGGTSYADSVKG 15 WRGLNYGFDVRYFDV crystal 1.90A 18.00% FV 01-NOV-93 19931101 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33 ? ? ? HOMO SAPIENS 11 RASQSISNNLH 7 YASQSIS 9 QQSNSWPLT 5 SYYMY 17 TISDGGSYTYYPDSVKG 5 DAMDY crystal 2.90A 19.80% FAB 31-JUL-00 20000731 IMMUNOGLOBULIN ROUTES TO CATALYSIS: STRUCTURE OF A CATALYTIC ANTIBODY AND COMPARISON WITH ITS NATURAL COUNTERPART ? KAPPA IGG1 MUS MUSCULUS 12 RASSSVSSTYLH 7 STSNLAS 9 QQYSGYPLT 5 GHNIN 17 NIDPYYGGTNFNPKFKG 10 RRDGNYGFTY crystal 3.00A 22.00% FAB 07-JAN-94 19940107 IMMUNE SYSTEM LYME DISEASE ANTIGEN OSPA IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB LA-2 MOLECULE: OUTER SURFACE PROTEIN A; SYNONYM: OSPA; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASQDINKYIA 7 YTSTLQP 9 LQYDNLQRT 5 DYSMY 17 WINTETGEPTYADDFKG 4 GLDS crystal 2.68A 0.00% FAB 07-AUG-00 20000807 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K WITH STILBENE HAPTEN AT 277K ? ? MUS MUSCULUS 16 RSTKSLLHSNGITYLY 7 QMSNLAS 9 AQNLELPPT 5 RYIMS 16 SISSGGITYYPDSVAG 6 GQGRPY crystal 2.45A 23.10% FAB 11-AUG-00 20000811 IMMUNE SYSTEM THE UNLIGANDED GERMLINE PRECURSOR TO THE SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4. ? KAPPA IGG1 HOMO SAPIENS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYMS 19 FIRNKANGYTTEYSASVKG 8 DGSYAMDY crystal 2.10A 22.60% ? 11-AUG-00 20000811 IMMUNE SYSTEM THE HAPTEN COMPLEXED GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4 GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4 ? ? HOMO SAPIENS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYMS 19 FIRNKANGYTTEYSASVKG 8 DGSYAMDY crystal 2.80A 21.60% ? 11-AUG-00 20000811 IMMUNOGLOBULIN 4-4-20 FAB FRAGMENT ? KAPPA ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLR 7 KVSNRFS 9 SQSTHVPWT 5 DYWMN 19 QIRNKPYNYETYYSDSVKG 7 SYYGMDY crystal 1.85A 18.80% FAB 19-JAN-95 19950119 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB198, AN EFFICIENT PROTECTOR OF ACETYLCHOLINE RECEPTOR AGAINST MYASTHENOGENIC ANTIBODIES ? ? ? RATTUS NORVEGICUS 11 KGSQNINNYLA 7 NTNSLQT 8 YQYNNGYT 5 SFSVS 16 RMWYDGYTAYNSALKS 15 DLYGGYPLGFWYFDF crystal 2.80A 19.80% FAB 21-AUG-00 20000821 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4 MOLECULE: VON WILLEBRAND FACTOR; FRAGMENT: A1 DOMAIN RESIDUES 507 - 702, OR GLYCOPROTEIN IBA (A\:ALPHA) BINDING DOMAIN; ENGINEERED: YES ? IGG1 MUS MUSCULUS 11 SASQDINKYLN 7 YTSSLHS 9 QQYEKLPWT 5 DYGVD 16 MIWGDGSTDYNSALKS 14 DPADYGNYDYALDY crystal 2.00A 17.20% FAB 23-AUG-00 20000823 IMMUNOGLOBULIN STRUCTURE DETERMINATION OF AN FAB FRAGMENT THAT NEUTRALIZES HUMAN RHINOVIRUS AND ANALYSIS OF THE FAB-VIRUS COMPLEX IMMUNOGLOBULIN STRUCTURE DETERMINATION OF AN FAB FRAGMENT THAT NEUTRALIZES HUMAN RHINOVIRUS AND ANALYSIS OF THE FAB-VIRUS COMPLEX KAPPA IGG2 MUS MUSCULUS 10 SATSSVNYMH 7 SSSNLAS 9 QQRSSYPIT 5 SFWVN 17 QIYPGDGDNKYNGKFKG 10 SGNYPYAMDY crystal 2.75A 17.40% FAB 24-MAY-94 19940524 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE HUMAN IGE-FC CEPSILON3- CEPSILON4 FRAGMENT. ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: TRICHOPLUSIA NI; EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER; EXPRESSION_SYSTEM_TAXID: 7111; EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS; EXPRESSION_SYSTEM_PLASMID: PACGP67A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.30A 24.20% FC 30-AUG-00 20000830 COMPLEX (ANTIBODY/PV-1 FRAGMENT) THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE MOLECULE: FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS; ENGINEERED: YES; KAPPA IGG2 MUS MUSCULUS 16 SSSQSLVHSNGKTYLH 7 KVSNRFS 9 SQSTHVPYT 5 NYLIQ 17 VINPGSGGTDYNANFKG 11 DFYDYDVGFDY crystal 3.00A 23.00% FAB 26-JAN-95 19950126 VIRAL PROTEIN/IMMUNE SYSTEM CRYSTAL STRUCTURE, SEQUENCE, AND EPITOPE MAPPING OF A PEPTIDE COMPLEX OF AN ANTI-INFLUENZA HA PEPTIDE ANTIBODY FAB 26(SLASH)9: FINE-TUNING ANTIBODY SPECIFICITY MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 101 - 108); ENGINEERED: YES ? IGG2 17 KSSQSLFNSGKRKNFLT 7 WASTRES 9 QNDYSHPLT 5 SFGMS 17 TISNGGGYTYYQDSVKG 11 RERYDEKGFAY crystal 2.80A 19.00% FAB 17-JAN-94 19940117 COMPLEX (RECEPTOR/IMMUNOGLOBULIN) CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; ORGAN: SERUM (MIXTURE OF SEVERAL SUBTYPES); GENE: BETA-2-MICROGLOBULIN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; EXPRESSION_SYSTEM_PLASMID: PBJ5-GS; MOL_ID: 2; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; ORGAN: SERUM (MIXTURE OF SEVERAL SUBTYPES); GENE: BETA-2-MICROGLOBULIN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; EXPRESSION_SYSTEM_PLASMID: PBJ5-GS; MOL_ID: 3; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; ORGAN: SERUM (MIXTURE OF SEVERAL SUBTYPES); GENE: BETA-2-MICROGLOBULIN; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL_LINE: CHO; EXPRESSION_SYSTEM_PLASMID: PBJ5-GS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 4.50A 42.30% FC 11-NOV-94 19941111 IMMUNE SYSTEM COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 MOLECULE: MAJOR POLLEN ALLERGEN BET V 1-A; SYNONYM: BET V I-A, BETVI ALLERGEN; ENGINEERED: YES; KAPPA IGG MUS MUSCULUS 11 KASENVDTYVF 7 GPSNRYT 9 GQSYSYPYT 5 SYWIN 17 NIFPSDSYTNYNQKFKD 9 GARDTWFAY crystal 2.90A 25.30% FAB 11-SEP-00 20000911 IMMUNOGLOBULIN X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING ? KAPPA IGG1 HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLYS 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.20A 18.30% FV 20-OCT-92 19921020 IMMUNOGLOBULIN X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING ? KAPPA IGG1 HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLES 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDV crystal 2.50A 17.90% FV 20-OCT-92 19921020 IMMUNOGLOBULIN X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING ? KAPPA IGG1 HOMO SAPIENS 11 RASQDVNTAVA 7 SASFLES 9 QQHYTTPPT 5 DTYIH 17 RIYPTNGYTRYADSVKG 11 WGGDGFYAMDY crystal 2.70A 17.10% FV 20-OCT-92 19921020 LYASE/IMMUNE SYSTEM COMPLEX OF THE CAMELID HEAVY-CHAIN ANTIBODY FRAGMENT CAB- CA05 WITH BOVINE CARBONIC ANHYDRASE MOLECULE: CARBONIC ANHYDRASE; EC: 4.2.1.1; ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 TYCMG 15 TILGGSTYYGDSVKG 19 STVASTGWCSRLRPYDYHY crystal 3.50A 21.00% HC-dimer 08-NOV-00 20001108 HYDROLASE INHIBITOR/HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3(VLW92A) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFASTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.85A 20.30% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR/HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92F) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFFSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.80A 18.80% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR/HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92H) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFHSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.75A 19.70% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR/HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92S) MOLECULE: LYSOZYME C; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFSSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.00A 20.70% ? 10-NOV-00 20001110 HYDROLASE INHIBITOR/HYDROLASE CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92V) MOLECULE: LYSOZYME C; SYNONYM: HEL; EC: 3.2.1.17 ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFVSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 1.90A 19.40% ? 10-NOV-00 20001110 IMMUNE SYSTEM THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); EXPRESSION_SYSTEM_TAXID: 469008; EXPRESSION_SYSTEM_STRAIN: BL21(DE3) 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A NMR N/A N/A FC 16-NOV-00 20001116 VIRAL PROTEIN/IMMUNE SYSTEM HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B MOLECULE: ENVELOPE GLYCOPROTEIN GP120; FRAGMENT: CORE; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYRNNGFLKH crystal 2.20A 26.80% FAB 24-NOV-00 20001124 VIRAL PROTEIN/IMMUNE SYSTEM HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B MOLECULE: ENVELOPE GLYCOPROTEIN GP120; FRAGMENT: CORE; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYRNNGFLKH crystal 2.90A 20.70% FAB 25-NOV-00 20001125 CATALYTIC ANTIBODY 48G7 HYBRIDOMA LINE FAB COMPLEXED WITH HAPTEN 5-(PARA- NITROPHENYL PHOSPHONATE)-PENTANOIC ACID HAPTEN 5-(PARA- NITROPHENYL PHOSPHONATE)-PENTANOIC ACID KAPPA ? HOMO SAPIENS 11 RASQEINGYLG 7 AASTLHS 9 LQYASYPRT 5 DTYMH 17 RIDPANVDTKYDPKFQD 5 YYGIY crystal 1.95A 24.40% FAB 06-FEB-96 19960206 VIRAL PROTEIN/RECEPTOR/IMMUNE SYSTEM HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY MOLECULE: ENVELOPE PROTEIN GP120; FRAGMENT: CORE; ENGINEERED: YES; MUTATION: YES; ? ? HOMO SAPIENS 11 RASESVSSDLA 7 GASTRAT 11 QQYNNWPPRYT 5 RYSFT 17 RIITILDVAHYAPHLQG 19 VYEGEADEGEYDNNGFLKH crystal 2.50A 21.00% FAB 15-JUN-98 19980615 IMMUNOGLOBULIN MAJOR ANTIGEN-INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY ? KAPPA IGG2 MUS MUSCULUS 15 RASESVDDDGNSFLH 7 RSSNLIS 9 QQSNEDPLT 7 TYGMGVS 16 HIFWDGDKRYNPSLKS 5 EGYIY crystal 2.80A 20.00% FAB 19-JUL-93 19930719 IMMUNOGLOBULIN MAJOR ANTIGEN-INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY ? KAPPA IGG2 MUS MUSCULUS 15 RASESVDDDGNSFLH 7 RSSNLIS 9 QQSNEDPLT 7 TYGMGVS 16 HIFWDGDKRYNPSLKS 5 EGYIY crystal 2.80A 19.00% FAB 19-JUL-93 19930719 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN MOLECULE: HIV-1 V3 LOOP PEPTIDE ANTIGEN; ENGINEERED: YES ? IGG2 15 RASESVDDDGNSFLH 7 RSSNLIS 9 QQSNEDPLT 7 TYGMGVS 16 HIFWDGDKRYNPSLKS 5 EGYIY crystal 2.80A 18.80% FAB 02-APR-93 19930402 ANTIBODY FAB FRAGMENT ANTI-ANTI-IDIOTYPE GH1002 FAB FRAGMENT ? ? ? MUS MUSCULUS 11 RESQDISNSLN 7 YTSRLHS 9 QQGNTLPYT 4 YGMN 17 WIQTNTEEPTYGAEFKG 7 VEAGFDY crystal 2.70A 21.00% FAB 30-NOV-95 19951130 IMMUNOGLOBULIN REFINED THREE-DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A MURINE IGG1, LAMBDA ANTIBODY ? LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNHWV 5 SNGVH 16 VIWAGGNTNYNSALMS 14 DFYDYDVFYYAMDY crystal 2.30A 19.50% FAB 20-JAN-93 19930120 IMMUNOGLOBULIN STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS ? ? ? MUS MUSCULUS 17 RSSQSLLNTRTRKSYLA 7 WASTRES 8 KQSYSLYT 5 SYAMS 17 EVSSDGSYAYYPDTLTG 7 FNWDVAY crystal 2.60A 19.41% FAB 09-SEP-01 20010909 IMMUNOGLOBULIN CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT ? ? ? SYNTHETIC CONSTRUCT 16 RASQSLVNEDGNTYLF 7 YASQSIS 9 QQITDWPFT 5 SDFWS 16 FVQYSGETAYNPSLKS 5 WHGDY crystal 1.95A 21.40% FAB 27-MAR-97 19970327 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN IN COMPLEX WITH FAB FRAGMENT OF ITS MONOCLONAL ANTIBODY MAB 26-2F MOLECULE: ANGIOGENIN; SYNONYM: RIBONUCLEASE 5, RNASE 5; ENGINEERED: YES ? ? HOMO SAPIENS 15 RASESVDNYGISFMS 7 AASNQGS 9 QQSKEVPLT 5 SYTMS 17 TISSGGGNTYYPDSVKG 12 LGDYGYAYTMDY crystal 2.00A 23.20% FAB 19-JUN-02 20020619 IMMUNOGLOBULIN STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS ? ? ? MUS MUSCULUS 17 RSSQSLLNTRTRKSYLA 7 WASTRES 8 KQSYSLYT 5 SYAMS 17 EVSSDGSYAYYPDTLTG 7 FNWDVAY crystal 2.60A 21.26% FAB 12-SEP-02 20020912 IMMUNOGLOBULIN/FC-FRAGMENT CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT,GLYCOFORM (MN2F)2 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.40A 28.00% FC 19-SEP-02 20020919 IMMUNOGLOBULIN/FC-FRAGMENT CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT,GLYCOFORM (G2F)2,SG P212121 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 3.10A 24.00% FC 19-SEP-02 20020919 IMMUNOGLOBULIN/FC-FRAGMENT CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT,GLYCOFORM (G2F)2, SG C2221 ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.85A 27.90% FC 19-SEP-02 20020919 ANTIBODY THREE-DIMENSIONAL STRUCTURE OF ANTI-AMPICILLIN SINGLE CHAIN FV FRAGMENT FROM PHAGE-DISPLAYED MURINE ANTIBODY LIBRARIES ? ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_TAXID: 10090; EXPRESSION_SYSTEM: ESCHERICHIA COLI; EXPRESSION_SYSTEM_TAXID: 562 11 CKASQDVGTAV 7 YWASTRH 10 CQQYSSYPLT 0 N/A 0 N/A 0 N/A crystal 1.87A 23.30% LC-dimer 14-FEB-01 20010214 ANTIBODY THREE-DIMENSIONAL STRUCTURE OF ANTI-AMPICILLIN SINGLE CHAIN FV FRAGMENT. ? ? ? MUS MUSCULUS 11 KASQDVGTAVA 7 WASTRHT 9 QQYSSYPLT 0 N/A 0 N/A 0 N/A crystal 2.75A 17.80% LC-dimer 14-FEB-01 20010214 ANTI-AMPICILLIN ANTIBODIES THREE-DIMENSIONAL STRUCTURE OF ANTI-AMPICILLIN SINGLE CHAIN FV FRAGMENT COMPLEXED WITH THE HAPTEN. THE HAPTEN. ? ? MUS MUSCULUS 11 KASQDVGTAVA 7 WASTRHT 9 QQYSSYPLT 0 N/A 0 N/A 0 N/A crystal 2.40A 20.40% LC-dimer 15-FEB-01 20010215 IMMUNOGLOBULIN LLAMA HEAVY CHAIN VARIABLE DOMAIN AGAINST ALPHA SUBUNIT OF HCG (HUMAN CHORIONIC GONADOTROPIN) ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYDMG 17 AINWDSARTYYASSVRG 8 GEGGTWDS crystal 1.85A 24.30% HC-dimer 13-JUL-96 19960713 MOL_ID: 1; MOLECULE: KAPPA LIGHT CHAIN OF IG; CHAIN: A, C; FRAGMENT: 1-214; MOL_ID: 2; MOLECULE: HEAVY CHAIN OF IG; CHAIN: B, D; FRAGMENT: 501-724; MOL_ID: 3; MOLECULE: PROTEIN L; CHAIN: E; FRAGMENT: 820-880 MOLECULE: PROTEIN L; FRAGMENT: 820-880 KAPPA ? HOMO SAPIENS 11 RTSQSISSYLN 7 AASSLQS 9 QQSYSTPRT 5 GYGMH 17 LISYDESNKYYADSVKG 12 VKFYDPTAPNDY crystal 2.70A 21.50% ? 27-NOV-00 20001127 IMMUNE SYSTEM ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MOLECULE: PEP-4; OTHER_DETAILS: EPITOPE-RELATED PEPTIDE KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.60A 33.80% FAB 21-DEC-00 20001221 IMMUNE SYSTEM/PEPTIDE ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MOLECULE: PEP-2; OTHER_DETAILS: EPITOPE-RELATED PEPTIDE KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.70A 28.20% FAB 21-DEC-00 20001221 IMMUNE SYSTEM/PEPTIDE ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MOLECULE: PEPTIDE 5; OTHER_DETAILS: EPITOPE-RELATED PEPTIDE KAPPA IGG2 MUS MUSCULUS 11 KASQDINSFLT 7 RANRLMI 9 LQYDDFPLT 5 DYEIH 17 GIHPGSSGTAYNQKFKG 3 KDY crystal 2.55A 28.40% FAB 02-JAN-01 20010102 IMMUNOGLOBULIN STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIGEN-ANTIBODY RECOGNITION ? KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 2.00A 19.50% FAB 08-JUL-92 19920708 IMMUNOGLOBULIN STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 100-108); ENGINEERED: YES; KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 2.90A 20.00% FAB 08-JUL-92 19920708 IMMUNOGLOBULIN STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 100-107); ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 3.10A 22.00% FAB 08-JUL-92 19920708 CATALYTIC ANTIBODY FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY ? ? ? HOMO SAPIENS 11 RASQEINGYLG 7 AASTLHS 9 LQYASYPRT 5 DTYMH 17 RIDPANVDTKYDPKFQD 5 YYGIY crystal 2.68A 18.40% FAB 20-DEC-96 19961220 IMMUNE SYSTEM STRUCTURE OF NATIVE CATALYTIC ANTIBODY HA5-19A4 ? ? ? MUS MUSCULUS 12 SASSSVSSNYVY 7 STSNLAS 9 LQWSSFPYT 6 SGYAWN 16 YIRYSGDTRYNPSLKS 7 GYGNSDY crystal 2.70A 22.50% FAB 14-DEC-00 20001214 TRANSFERASE/DNA-RNA HYBRID CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA MOLECULE: 5'- R(*UP*CP*AP*GP*CP*CP*AP*CP*UP*UP*UP*UP*UP*AP*AP*AP*AP*GP*AP *AP*AP*AP*G)-3'; ENGINEERED: YES; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.00A 27.40% FAB 22-JAN-01 20010122 CATALYTIC ANTIBODY HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION-STATE ANALOG OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION-STATE ANALOG ? ? MUS MUSCULUS 16 RSSQTIVHSNGDTYLD 7 KVSNRFS 9 FQGSHVPPT 5 NYAMS 16 SISSGGSIYYLDSVKG 14 VSHYDGSRDWYFDV crystal 1.80A 19.80% FAB 07-JUN-97 19970607 CATALYTIC ANTIBODY CRYSTAL FORM II: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION-STATE ANALOG OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION-STATE ANALOG ? ? MUS MUSCULUS 16 RSSQTIVHSNGDTYLD 7 KVSNRFS 9 FQGSHVPPT 5 NYAMS 16 SISSGGSIYYLDSVKG 14 VSHYDGSRDWYFDV crystal 1.80A 22.80% FAB 08-JUN-97 19970608 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN ? ? IGG HOMO SAPIENS 12 RSSHSIRSRRVA 7 GVSNRAS 9 QVYGASSYT 5 NFVIH 17 WINPYNGNKEFSAKFQD 18 VGPYSWDDSPQDNYYMDV crystal 2.70A 22.90% ? 24-JAN-01 20010124 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC ? ? IGG MOL_ID: 1; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS; MOL_ID: 2; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS; MOL_ID: 3; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS; MOL_ID: 4; ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS; ORGANISM_COMMON: NORWAY RAT; ORGANISM_TAXID: 10116; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_STRAIN: CHO-K1; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; EXPRESSION_SYSTEM_PLASMID: PBJ-5GS 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.80A 22.20% FC 31-JAN-01 20010131 ANTIBIOTIC CRYSTAL STRUCTURE OF AN AMPICILLIN SINGLE CHAIN FV, FORM 1, FREE ? ? ? MUS MUSCULUS 11 KASQDVGTAVA 7 WASTRHT 9 QQYSSYPLT 5 SYWIN 17 NIYPSDSYTNYNQKFKD 3 WGY crystal 2.44A 17.50% FV 15-FEB-01 20010215 IMMUNE SYSTEM THREE-DIMENSIONAL STRUCTURE OF A LLAMA VHH DOMAIN COMPLEXED WITH THE DYE RR1 ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYVIG 19 TIGRNLVGPSDFYTRYADS 18 CAAKTTTWGGNDPNNWNY crystal 1.95A 23.20% HC-dimer 16-FEB-01 20010216 IMMUNE SYSTEM THREE-DIMENSIONAL STRUCTURE OF A LAMA VHH DOMAIN UNLIGANDED ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 TYVIG 19 TIGRNLVGPSDFYTRYADS 18 CAAKTTTWGGNDPNNWNY crystal 2.03A 21.20% HC-dimer 16-FEB-01 20010216 IMMUNE SYSTEM ANTIBODY GNC92H2 BOUND TO LIGAND AND MOUSE VARIABLE REGION; ENGINEERED: YES; OTHER_DETAILS: THE CHIMERA CONSISTS OF RESIDUES 1-108 OF MOUSE PORTION AND 109-214 OF HUMAN PORTION OF IG KAPPA CHAIN.; KAPPA ? MUS MUSCULUS, HOMO SAPIENS 15 RASKSVSTSGYNYMH 7 LASNLAS 10 LYSREFPPWT 5 NYGMN 17 WINTYTGEPTYADDFRG 8 YDSPLGDY crystal 2.30A 22.00% ? 12-MAR-01 20010312 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT ROOM TEMPERATURE MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; FRAGMENT: N-TERMINAL FRAGMENT; SYNONYM: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 KFGMS 17 SISTGGYNTYYSDNVKG 11 GYSSTSYAMDY crystal 2.40A 15.60% FV 14-MAR-01 20010314 IMMUNE SYSTEM CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; FRAGMENT: N-TERMINAL FRAGMENT; SYNONYM: EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN; ENGINEERED: YES ? ? MUS MUSCULUS 11 MTSTDIDDDMN 7 EGNTLRP 9 LQSFNVPLT 5 KFGMS 17 SISTGGYNTYYSDNVKG 11 GYSSTSYAMDY crystal 1.80A 17.20% FV 14-MAR-01 20010314 IMMUNE SYSTEM/DNA CRYSTAL STRUCTURE OF A RECOMBINANT ANTI-SINGLE-STRANDED DNA ANTIBODY FRAGMENT COMPLEXED WITH DT5 MOLECULE: 5'-D(*TP*TP*TP*TP*T)-3'; ENGINEERED: YES; ? ? MUS MUSCULUS 11 RASENIYSYLA 7 NAKTLAE 9 QHHYGTPLT 5 SYVMH 17 YINPYNDGTKYNEKFKG 11 GGYRPYYAMDY crystal 2.10A 22.00% FAB 14-MAR-01 20010314 IMMUNE SYSTEM NATIVE CRYSTAL STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RSSQSIVHSNGNSYLE 7 KVSNRFS 9 FQGSHVPPT 5 TYALS 16 SIVSGGNTYYSGSVKG 10 EYYGYVGLAY crystal 2.72A 19.50% FAB 20-MAR-01 20010320 IMMUNE SYSTEM TESTOSTERONE COMPLEX STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT ? ? MUS MUSCULUS 16 RSSQSIVHSNGNSYLE 7 KVSNRFS 9 FQGSHVPPT 5 TYALS 16 SIVSGGNTYYSGSVKG 10 EYYGYVGLAY crystal 2.60A 18.80% FAB 20-MAR-01 20010320 CYTOKINE/IMMUNE SYSTEM STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY MOLECULE: CD40 LIGAND; FRAGMENT: RESIDUES 116-261; SYNONYM: CD40-L; ENGINEERED: YES; ? ? HOMO SAPIENS 15 RASQRVSSSTYSYMH 7 YASNLES 9 QHSWEIPPT 5 SYYMY 17 EINPSNGDTNFNEKFKS 9 SDGRNDMDS crystal 3.10A 23.30% FAB 20-MAR-01 20010320 730.1.4 VIRUS NEUTRALIZING ANTIBODY 409.5.3 ANTI-IDIOTYPIC ANTIBODY ? IGG1 MUS MUSCULUS 11 KASQDVSTAVA 7 SASYQYT 9 HQHYSTPFT 5 NYGMN 17 WINTYTGEPTYADDFKG 12 DGYYENYYAMDY crystal 2.90A 21.00% FAB 28-DEC-93 19931228 409.5.3 ANTI-IDIOTYPIC ANTIBODY 730.1.4 VIRUS NEUTRALIZING ANTIBODY ? IGG2A MUS MUSCULUS 12 SVSSSISSSNLH 7 GTSNLAS 9 QQWNSYPYT 5 NYWMS 19 EIRLNSDNFATHYAESVKG 10 RPLFYYAVDY crystal 2.90A 21.00% FAB 28-DEC-93 19931228 IMMUNOGLOBULIN STRUCTURE AND SPECIFICITY OF THE ANTI-DIGOXIN ANTIBODY 40-50 ? KAPPA IGG2 15 RASKSVSTSGYSHIH 7 LASILES 9 QHSREYPLT 5 TYGVH 16 LIWAGGNTDYNSALMS 13 FRFASYYDYAVDY crystal 2.70A 20.90% FAB 25-OCT-94 19941025 PROTEIN BINDING/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD32A)-HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA IGG1 MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SAYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 2.50A 27.90% FV 30-MAR-01 20010330 PROTEIN BINDING/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD99A)-HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA IGG1 MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WAGDY crystal 2.30A 25.20% FV 30-MAR-01 20010330 PROTEIN BINDING/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD32A99A)-HEN LYSOZYME COMPLEX MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA IGG1 MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNSWPYT 5 SAYWS 16 YVSYSGSTYYNPSLKS 5 WAGDY crystal 2.10A 23.00% FV 30-MAR-01 20010330 IMMUNE SYSTEM SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE ? ? ? LAMA GLAMA 0 N/A 0 N/A 0 N/A 5 SYHMA 17 TINPGDGSTYYADSVKG 8 YSGGALDA NMR N/A N/A HC-dimer 09-APR-01 20010409 IMMUNOGLOBULIN A DETAILED ANALYSIS OF THE FREE AND BOUND CONFORMATION OF AN ANTIBODY: X-RAY STRUCTURES OF ANTI-PEPTIDE FAB 17(SLASH)9 AND THREE DIFFERENT FAB-PEPTIDE COMPLEXES MOLECULE: INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 101-107); ENGINEERED: YES KAPPA IGG2 MUS MUSCULUS 17 TSSQSLFNSGKQKNYLT 7 WASTRES 9 QNDYSNPLT 5 SYGMS 17 TISNGGGYTYYPDSVKG 11 RERYDENGFAY crystal 2.80A 17.00% FAB 06-MAY-93 19930506 IMMUNOGLOBULIN MODEL OF HUMAN IGA1 DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING MOLECULE: IGA1; FRAGMENT: CHAINS A AND B, HEAVY, CHAINS C AND D, LIGHT ? IGA HOMO SAPIENS 11 RASQGISSALA 7 DASNLES 9 QQFNSYPLT 5 SYGLH 17 WISAGTGNTKYSQKFRG 12 DPYGGGKSEFDY model N/A N/A ? 23-DEC-98 19981223 COMPLEX (ANTIBODY/BINDING PROTEIN) IGG1 FAB FRAGMENT (MOPC21) COMPLEX WITH DOMAIN III OF PROTEIN G FROM STREPTOCOCCUS MOLECULE: STREPTOCOCCAL PROTEIN G (DOMAIN III); ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 KASENVVTYVS 7 GASNRYT 9 GQGNSYPYT 5 SFGMH 17 YISSGSSTLHYADTVKG 11 WGNYPYYAMDY crystal 2.60A 16.80% FAB 05-AUG-94 19940805 IMMUNOGLOBULIN CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS KAPPA IGG1 MUS MUSCULUS 16 RSNQTILLSDGDTYLE 7 KVSNRFS 9 FQGSHVPPT 5 RCAMS 17 GISSGGSYTFYPDTVKG 10 YSSDPFYFDY crystal 2.80A 18.00% FAB 21-MAR-91 19910321 IMMUNOGLOBULIN 26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY -AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 5 DFYMN 17 YISPYSGVTGYNQKFKG 10 SSGNKWAMDY crystal 2.70A 17.70% FAB 19-FEB-93 19930219 IMMUNOGLOBULIN 26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY -AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY KAPPA IGG2 MUS MUSCULUS 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 5 DFYMN 17 YISPYSGVTGYNQKFKG 10 SSGNKWAMDY crystal 2.50A 17.60% FAB 19-FEB-93 19930219 IMMUNOGLOBULIN THREE DIMENSIONAL STRUCTURE OF AN FV FROM A HUMAN IGM IMMUNOGLOBULIN ? KAPPA IGM HOMO SAPIENS 11 QASQDISNYLA 7 DASNLET 9 QQYQNLPLT 5 IFVMS 17 GVFGSGGNTDYADAVKG 12 HRVSYVLTGFDS crystal 2.30A 20.10% FV 10-JUL-92 19920710 IMMUNOGLOBULIN STRUCTURE OF IMMUNOGLOBULIN ? ? IGG2 MUS MUSCULUS 11 HASQNINVWLS 7 KASNLHT 9 QQGQSYPLT 5 DYYMY 17 YISNGGGSTYYPDTVKG 9 HGGYYAMDY crystal 2.80A 20.90% ? 25-OCT-96 19961025 IMMUNOGLOBULIN STRUCTURE OF IMMUNOGLOBULIN ? ? IGG1 MUS MUSCULUS 11 KASENVVTYVS 7 GASNRYT 9 GQGYSYPYT 5 TYTIH 17 YINPSSVYTNYNQRFKD 6 EGEVPY crystal 3.20A 21.10% ? 09-OCT-97 19971009 COMPLEX (ANTIBIDY/IMMUNOSUPPRESSANT) A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX MOLECULE: CYCLOSPORIN; ENGINEERED: YES KAPPA IGG1 11 RASQDISTYLN 7 YTSRLRS 9 QQGSRIPPT 5 DYYMY 17 FISNGGGSAFYADIVKG 17 HTLYDTLYGNYPVWFAD crystal 2.50A 16.40% FAB 09-DEC-93 19931209 IMMUNE SYSTEM CRYSTAL STRUCTURE OF G3-519, AN ANTI-HIV MONOCLONAL ANTIBODY ? ? ? MUS MUSCULUS 17 KSSQSLLYSRNQMNYLS 7 WASTRES 8 QQYYHYRT 5 DYYIH 17 WLDPENGDTESAPKFQG 12 ISTTRDYYALDY crystal 2.20A 18.80% FAB 07-MAY-01 20010507 IMMUNOGLOBULIN HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE ES WITH DIFFERENT METALS IN THE CHELATE LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNLWV 5 GETMS 17 TTLSGGGFTFYSASVKG 5 HRFVH crystal 2.20A 18.80% FAB 14-JUN-93 19930614 IMMUNOGLOBULIN HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE ES WITH DIFFERENT METALS IN THE CHELATE LAMBDA IGG1 MUS MUSCULUS 14 RSSTGAVTTSNYAN 7 GTNNRAP 9 ALWYSNLWV 5 GETMS 17 TTLSGGGFTFYSASVKG 5 HRFVH crystal 2.80A 17.60% FAB 14-JUN-93 19930614 IMMUNE SYSTEM/BLOOD CLOTTING HUMAN FACTOR VIII C2 DOMAIN COMPLEXED TO HUMAN MONOCLONAL BO2C11 FAB. MOLECULE: HUMAN FACTOR VIII; FRAGMENT: C-TERMINAL DOMAIN; SYNONYM: COAGULATION FACTOR VII; ENGINEERED: YES; MUTATION: YES ? ? HOMO SAPIENS 12 RASQSFSSSYLA 7 GASTRAT 9 QKYGTSAIT 5 ELPVH 17 SFDPESGESIYAREFQG 8 PDPDAFDI crystal 2.00A 20.30% FAB 21-JUL-01 20010721 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MOUSE ANTI- HUMAN FAS ANTIBODY HFE7A ? ? ? MUS MUSCULUS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 12 NRDYSNNWYFDV crystal 2.50A 16.80% FAB 10-AUG-01 20010810 IMMUNE SYSTEM CRYSTAL STRUCTURE OF AN ANTIGEN-BINDING FRAGMENT FROM A HUMANIZED VERSION OF THE ANTI-HUMAN FAS ANTIBODY HFE7A ? ? ? MUS MUSCULUS, HOMO SAPIENS 15 KASQSVDYDGDSYMN 7 AASNLES 9 QQSNEDPRT 5 SYWMQ 17 EIDPSDSYTNYNQKFKG 12 NRDYSNNWYFDV crystal 2.80A 20.20% FAB 11-JAN-02 20020111 IMMUNOGLOBULIN THE DE NOVO DESIGN OF AN ANTIBODY COMBINING SITE: CRYSTALLOGRAPHIC ANALYSIS OF THE VL DOMAIN CONFIRMS THE STRUCTURAL MODEL ? KAPPA IGG SYNTHETIC CONSTRUCT 11 RASQSIGNRLF 7 YASQSIS 9 QQVSEWPFT 0 N/A 0 N/A 0 N/A crystal 2.17A 17.50% LC-dimer 04-MAY-94 19940504 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY T84.66 FV FRAGMENT ? ? ? MUS MUSCULUS 15 RAGESVDIFGVGFLH 7 RASNLES 9 QQTNEDPYT 5 DTYMH 17 RIDPANGNSKYVPKFQG 12 FGYYVSDYAMAY crystal 1.50A 19.00% FV 01-NOV-02 20021101 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT LY50F COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 FASQSIS 9 QQSNSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 19.00% FV 13-DEC-02 20021213 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT LS91A COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQANSWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 19.10% FV 13-DEC-02 20021213 IMMUNE SYSTEM/HYDROLASE CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT LS93A COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME C; EC: 3.2.1.17 KAPPA ? MUS MUSCULUS 11 RASQSIGNNLH 7 YASQSIS 9 QQSNAWPYT 5 SDYWS 16 YVSYSGSTYYNPSLKS 5 WDGDY crystal 1.80A 18.90% FV 20-DEC-02 20021220 TRANSFERASE/IMMUNE SYSTEM/DNA CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE- PRIMER MOLECULE: 5'- D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C) -3'; ENGINEERED: YES; ? ? MUS MUSCULUS 11 SASQDISSYLN 7 YTSSLHS 9 QQYSKFPWT 7 TSGIGVT 16 TIWWDDDNRYNPSLKS 13 SAITSVTDSAMDH crystal 3.50A 26.20% FAB 24-MAY-02 20020524 FAB JE142 MONOCLONAL ANTIBODY COMPLEXED WITH HISTIDINE- CONTAINING PROTEIN (HPR) HISTIDINE- CONTAINING PROTEIN (HPR) ? ? FAB JE142: MOUSE (MUS MUSCULUS, STRAIN BALB/C); HISTIDINE CONTAINING PROTEIN: (ESCHERICHIA COLI) 16 RSSQSIVHGNGNTYLE 7 SISSRFS 9 FQGSHVPYT 5 TYAMH 17 LISPSSGYTSYNGEFKG 9 VMGEQYFDV crystal 2.80A 19.30% FAB 02-APR-93 19930402 IMMUNE SYSTEM ANTIGEN-BINDING FRAGMENT OF THE MURINE ANTI-PHENYLARSONATE ANTIBODY 36-71, "FAB 36-71" ? ? ? MUS MUSCULUS 11 RASQDINNFLN 7 FTSRSQS 9 QQGNALPRT 5 SNGIN 17 YNNPGNGYITYNEKFKG 12 SEYYGGSYKFDY crystal 1.90A 19.60% FAB 21-JUN-01 20010621 IMMUNE SYSTEM CRYSTAL STRUCTURE OF IMMUNOGLOBULIN FAB FRAGMENT COMPLEXED WITH 17-BETA-ESTRADIOL MOLECULE: IG KAPPA-CHAIN; ENGINEERED: YES; KAPPA ? MUS MUSCULUS 11 RASGNIHNYLA 7 NAKTLAD 9 HHFWSTPWT 3 GMQ 17 WLNTQSGVPEYAEDFKG 7 WGGNSAY crystal 2.15A 19.90% FAB 26-JUN-01 20010626 IMMUNE SYSTEM STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4 ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 5 GYAMS 16 SIYNGFRIHYLDSVKG 10 GDAYSRYFDV crystal 1.80A 20.90% ? 26-JUN-01 20010626 IMMUNE SYSTEM STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4 ? ? ? MUS MUSCULUS 16 RSSQSLVHSNGNTYLH 7 KVSNRFS 10 SQSTHVPPLT 5 GYAMS 16 SIYNGFRIHYLDSVKG 10 GDAYSRYFDV crystal 1.85A 20.60% ? 26-JUN-01 20010626 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-ESTRADIOL ANTIBODY 57-2 MOLECULE: IG GAMMA-1-CHAIN; FRAGMENT: RESIDUES 1-215; ENGINEERED: YES KAPPA GAMMA MOUSE 11 RASGNIHNYLA 7 NAKTLAD 9 HHFWSTPWT 5 TSGMQ 17 WLNTQSGVPEYAEDFKG 7 WGGNSAY crystal 2.51A 19.80% FAB 28-JUN-01 20010628 COMPLEX(ANTIBODY-ANTIGEN) THREE-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN- ANTIBODY CROSS-REACTION COMPLEX MOLECULE: PHEASANT EGG WHITE LYSOZYME; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 RASKSISKSLA 7 SGSTLQS 9 QQHNEYPWT 5 SYWIN 17 NIYPSDSYTNYNQKFKD 9 DDNYGAMDY crystal 2.40A 21.40% FV 04-MAY-93 19930504 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB-ESTRADIOL COMPLEXES ES LAMBDA ? MUS MUSCULUS 14 RSSSGAITTSHYAN 7 GTNNRAP 9 ALWFSNQFI 5 TYWMQ 17 AIYPGDDDARYTQKFKG 10 GRSLYYTMDY crystal 2.70A 22.30% FAB 23-JUL-01 20010723 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB-ESTRADIOL COMPLEXES ES LAMBDA ? MUS MUSCULUS 14 RSSSGAITTSHYAN 7 GTNNRAP 9 ALWFSNQFI 5 TYWMQ 17 AIYPGDDDARYTQKFKG 10 GRSLYYTMDY crystal 2.85A 19.80% FAB 24-JUL-01 20010724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB-ESTRADIOL COMPLEXES ES KAPPA ? MUS MUSCULUS 11 RASGNIYNYLA 7 NAKTLVD 9 HHFWNTPYT 5 DTYMF 17 RINPANGISKYDPRFQG 5 EKDLP crystal 3.00A 19.50% FAB 24-JUL-01 20010724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB-ESTRADIOL COMPLEXES ES KAPPA ? MUS MUSCULUS 11 RASGNIYNYLA 7 NAKTLVD 9 HHFWNTPYT 5 DTYMF 17 RINPANGISKYDPRFQG 5 EKDLP crystal 3.20A 21.10% FAB 24-JUL-01 20010724 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE SINGLE-CHAIN FV FRAGMENT 1696 IN COMPLEX WITH THE EPITOPE PEPTIDE CORRESPONDING TO N- TERMINUS OF HIV-1 PROTEASE MOLECULE: EPITOPE PEPTIDE CORRESPONDING TO N-TERMINUS OF HIV-1 PROTEASE; ENGINEERED: YES; OTHER_DETAILS: NONAPEPTIDE PQITLWQRR KAPPA IGG1 MUS MUSCULUS 0 ? 0 ? 0 ? 0 ? 0 ? 0 ? crystal 2.70A 22.90% LC-dimer 01-AUG-01 20010801 IMMUNE SYSTEM CRYSTAL STRUCTURE OF TISSUE FACTOR IN COMPLEX WITH HUMANIZED FAB D3H44 MOLECULE: TISSUE FACTOR; FRAGMENT: EXTRACELLULAR DOMAIN; ENGINEERED: YES ? ? HOMO SAPIENS 11 RASRDIKSYLN 7 YATSLAE 9 LQHGESPWT 5 EYYMH 17 LIDPEQGNTIYDPKFQD 8 DTAAYFDY crystal 1.85A 20.10% FAB 03-AUG-01 20010803 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB D3H44 ? ? ? HOMO SAPIENS 11 RASRDIKSYLN 7 YATSLAE 9 LQHGESPWT 5 EYYMH 17 LIDPEQGNTIYDPKFQD 8 DTAAYFDY crystal 1.85A 18.20% FAB 03-AUG-01 20010803 MOL_ID: 1; MOLECULE: ANTIBODY A6; CHAIN: L; FRAGMENT: FAB FRAGMENT;PEPSIN DIGESTION OF INTACT ANTIBODY; MOL_ID: 2; MOLECULE: ANTIBODY A6; CHAIN: H; FRAGMENT: FAB FRAGMENT;PEPSIN DIGESTION OF INTACT ANTIBODY; MOL_ID: 3; MOLECULE: INTERFERON-GAMMA RECEPTOR ALPHA CHAIN; CHAIN: I; FRAGMENT: N-TERMINAL DOMAIN; ENGINEERED: YES; MUTATION: YES MOLECULE: INTERFERON-GAMMA RECEPTOR ALPHA CHAIN; FRAGMENT: N-TERMINAL DOMAIN; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 KASEDIYNRLA 7 GATSLET 8 QQYWSTWT 7 TYGMGVG 16 HIWWDDDKYYNPSLKS 12 RAPFYGNHAMDY crystal 2.80A 24.60% FAB 23-SEP-97 19970923 ANTIBODY,HYDROLASE DEGENERATE INTERFACES IN ANTIGEN-ANTIBODY COMPLEXES MOLECULE: LYSOZYME; FRAGMENT: ENZYME; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 2.50A 17.30% HC-dimer 21-AUG-01 20010821 ANTIBODY, HYDROLASE DEGENERATE INTERFACES IN ANTIGEN-ANTIBODY COMPLEXES MOLECULE: LYSOZYME C; FRAGMENT: ENZYME; SYNONYM: 1,4-BETA-N-ACETYLMURAMIDASE C; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 1.90A 18.40% HC-dimer 21-AUG-01 20010821 IMMUNE SYSTEM, LYSOZYME DEGENERATE INTERFACES IN ANTIGEN-ANTIBODY COMPLEXES MOLECULE: LYSOZYME; FRAGMENT: ENZYME; SYNONYM: 1,4-BETA-N-ACETYLMURAMIDASE C, ALLERGEN GAL D IV; EC: 3.2.1.17 ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 2.10A 16.40% HC-dimer 22-AUG-01 20010822 IMMUNE SYSTEM THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR ? LAMBDA ? HOMO SAPIENS 14 TGVSSIVGSYNLVS 7 EVNKRPS 11 SSYDGSSTSVV 0 N/A 0 N/A 0 N/A crystal 1.94A 22.30% LC-dimer 30-AUG-01 20010830 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA-FAB COMPLEX IN HIGH CONCENTRATION OF K+ MOLECULE: POTASSIUM CHANNEL KCSA; FRAGMENT: POTASSIUM CHANNEL KCSA; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.00A 21.80% FAB 07-OCT-01 20011007 MEMBRANE PROTEIN POTASSIUM CHANNEL KCSA-FAB COMPLEX IN LOW CONCENTRATION OF K+ MOLECULE: POTASSIUM CHANNEL KCSA; FRAGMENT: POTASSIUM CHANNEL KCSA; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 11 RASQSIGTDIH 7 YASESIS 9 QQSNRWPFT 5 SDWIH 17 EIIPSYGRANYNEKIQK 9 ERGDGYFAV crystal 2.30A 21.80% FAB 07-OCT-01 20011007 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY FAB FRAGMENT D3 ? ? ? MUS MUSCULUS 11 KASRDIKSYLS 7 YATSLAD 9 LQHGESPFT 5 DYYMH 17 WIDPENGNTIYDPKFQD 8 DTAAYFDY crystal 2.40A 22.50% FAB 17-OCT-01 20011017 COMPLEX (IMMUNOGLOBULIN/RECEPTOR) MURINE T-CELL RECEPTOR VARIABLE DOMAIN/FAB COMPLEX MOLECULE: KB5-C20 T-CELL ANTIGEN RECEPTOR; FRAGMENT: FV FRAGMENT, VARIABLE DOMAIN; SYNONYM: TCR VAPLHA VBETA DOMAIN; ENGINEERED: YES; OTHER_DETAILS: 24 RESIDUE LINK BETWEEN VALPHA C-TERMINUS AND VBETA N-TERMINUS; ? Gamma 2A MUS MUSCULUS 11 RASKNIYSYLA 7 NAKTLGE 9 QHHYGTPYT 5 GYNMN 17 NIDPYYGGISYNQKFKG 10 SRTDLYYFDY crystal 2.50A 22.10% FAB 06-APR-97 19970406 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE MOLECULE: PS1 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASENVDTYVS 7 GASNRYT 9 GQSYSYPLT 6 SDYAWN 16 YISYSGSTTYNPSLKS 7 GGTGFDY crystal 2.50A 19.50% ? 07-NOV-01 20011107 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC283 IN COMPLEX WITH PS1 PEPTIDE MOLECULE: PS1 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 8 GQTYSYPT 6 SDYAWN 16 YIRNGGSTTYNPSLAS 7 GGTGFTY crystal 2.90A 18.40% ? 11-NOV-01 20011111 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC282 IN COMPLEX WITH PS1 PEPTIDE MOLECULE: PS1 PEPTIDE; ENGINEERED: YES ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 9 GQSYSSPLT 6 SDYAWN 16 YISYSGSTSYNPSLKS 7 GGTGFPY crystal 2.50A 20.90% ? 11-NOV-01 20011111 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC287 ? ? ? MUS MUSCULUS 11 KASENVDTYVS 7 GASNRYT 9 GQSYSYPLT 6 SDYAWN 16 YISYSGSTTYNPSLKS 7 GGTGFDY crystal 2.20A 20.00% ? 11-NOV-01 20011111 IMMUNE SYSTEM CRYSTAL STRUCTURE OF ANTIBODY PC282 ? ? ? MUS MUSCULUS 11 KASENVGTYVS 7 GASNRYT 9 GQSYSSPLT 6 SDYAWN 16 YISYSGSTSYNPSLKS 7 GGTGFPY crystal 1.80A 20.30% FAB 11-NOV-01 20011111 IMMUNE SYSTEM/DNA ANTIBODY 64M-2 FAB COMPLEXED WITH DTT(6-4)TT MOLECULE: 5'-D(*TP*(64T)P*TP*T)-3'; ENGINEERED: YES; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 8 FQGSLVPT 5 SFWMH 17 TIYPGNSDTSYNQKFKG 11 RSGYKYYALDY crystal 2.40A 20.10% FAB 15-NOV-01 20011115 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 28B4 FAB FRAGMENT COMPLEXED WITH HAPTEN (1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO] METHYLPHOSPHONIC ACID) HAPTEN (1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO] METHYLPHOSPHONIC ACID) ? ? MUS MUSCULUS 16 RFSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYFN 19 FIRNKAKGYTTEYSASVKG 8 WGSYAMDY crystal 1.90A 19.90% FAB 16-APR-96 19960416 CATALYTIC ANTIBODY CATALYTIC ANTIBODY 28B4 FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RFSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPRT 5 DYYFN 19 FIRNKAKGYTTEYSASVKG 8 WGSYAMDY crystal 2.20A 18.30% FAB 16-APR-96 19960416 VIRAL PROTEIN/IMMUNE SYSTEM INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION MOLECULE: HEMAGGLUTININ HA1; ? ? MUS MUSCULUS 12 SASSTITSSFLY 7 STSNLAS 9 HQWETFPRT 6 SGYYWT 16 YISYDGSNNYNPSLKN 11 FYYDYDFFFDY crystal 3.50A 25.50% FAB 16-NOV-01 20011116 IMMUNE SYSTEM CRYSTAL STRUCTURE OF FAB FRAGMENT COMPLEXED WITH GIBBERELLIN A4 GIBBERELLIN A4 ? ? HOMO SAPIENS 16 RSSQSLVHSNGNTYLH 7 KVSSRFS 9 SQSTHVPFT 5 SYAMS 16 TITTRGYTFYPDSVKG 12 EGLLLDYFTMDY crystal 2.80A 23.50% FAB 20-NOV-01 20011120 COMPLEX (IMMUNOGLOBULIN/HYDROLASE) FV MUTANT Y(B 32)A (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GAGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.10A 16.20% FV 23-OCT-96 19961023 COMPLEX (IMMUNOGLOBULIN/HYDROLASE) FV MUTANT Y(B 101)F (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 YTTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDFRLDY crystal 1.85A 18.10% FV 23-OCT-96 19961023 COMPLEX (IMMUNOGLOBULIN/HYDROLASE) FV MUTANT Y(A 50)S (VL DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? MUS MUSCULUS 11 RASGNIHNYLA 7 STTTLAD 9 QHFWSTPRT 5 GYGVN 16 MIWGDGNTDYNSALKS 8 ERDYRLDY crystal 2.00A 16.70% FV 23-OCT-96 19961023 IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 1.90A 21.30% ? 18-DEC-01 20011218 IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX IMMUNE SYSTEM CATALYTIC ANTIBODY D2.3 COMPLEX ? ? MUS MUSCULUS 16 KSSQSLLYSNGKTYLN 7 LVSKLDS 9 VQGTHFPYT 5 SYWIH 17 RIYPGTGSTYYNEKFKG 14 WGFIPVREDYVMDY crystal 1.90A 21.30% ? 18-DEC-01 20011218 CATALYTIC ANTIBODY CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES ? IGG2 MUS MUSCULUS 11 RASQEISGYLS 7 AASTLDS 9 LQYASSPYT 5 SFGMH 17 YISSGSSTIYYADTVKG 10 GDYYGSRGAY crystal 3.20A 20.00% FAB 11-SEP-95 19950911 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-HIS TAG ANTIBODY 3D5 SINGLE- CHAIN FRAGMENT (SCFV) IN COMPLEX WITH A OLIGOHISTIDINE PEPTIDE MOLECULE: PEPTIDE LINKER; ENGINEERED: YES; OTHER_DETAILS: THE PEPTIDE LINKER CONNECTS THE VARIABLE LIGHT CHAIN AND THE VARIABLE HEAVY CHAIN.; ? ? MUS MUSCULUS 16 RSSQSIVHSNGNTYLE 7 KVSNRFS 9 FQGSHVPFT 5 DYYMN 17 DINPNNGGTSYNQKFKG 5 QSGAY crystal 2.70A 19.00% FV 17-JAN-02 20020117 IMMUNE SYSTEM FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B-DOMAIN FROM PROTEIN A CALLED Z34C ? ? IGG1 MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606; EXPRESSION_SYSTEM: CRICETULUS GRISEUS; EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER; EXPRESSION_SYSTEM_TAXID: 10029; EXPRESSION_SYSTEM_CELL: OVARY; EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; MOL_ID: 2; SYNTHETIC: YES; OTHER_DETAILS: PHAGE OPTIMIZED SEQUENCE FROM THE B-DOMAIN OF PROTEIN A STAPHYLOCOCCUS AUREUS. PEPTIDE PREPARED USING N-FLUORENYL-METHOXYCARBONYL CHEMISTRY ON WANG RESIN. 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 1.65A 20.60% FC 14-MAR-02 20020314 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE ANTI-ERBB2 FAB2C4 : THE CHIMERA CONSISTS OF THE HUMAN IG AND THE ORIGINAL MURINE SEQUENCE; ? ? HOMO SAPIENS 11 KASQDVSIGVA 7 SASYRYT 9 QQYYIYPYT 5 DYTMD 17 DVNPNSGGSIYNQRFKG 10 NLGPSFYFDY crystal 1.80A 23.00% FAB 15-MAR-02 20020315 IMMUNE SYSTEM CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-TESTOSTERONE FAB FRAGMENT ? ? ? MUS MUSCULUS 16 RSSEVIVTRNGYTPIE 7 KAYKRFP 9 FDGSTVPPK 5 RYALS 16 SIVSGGNTYYSGSVKG 10 AYYGYVGLVH crystal 2.10A 21.30% FAB 17-MAR-02 20020317 IMMUNE SYSTEM STRUCTURE OF A HUMAN BENCE-JONES DIMER CRYSTALLIZED IN U.S. SPACE SHUTTLE MISSION STS-95: 100K ? LAMBDA ? HOMO SAPIENS 14 TGVSSIVGSYNLVS 7 EVNKRPS 11 SSYDGSSTSVV 0 N/A 0 N/A 0 N/A crystal 1.95A 20.00% LC-dimer 16-APR-02 20020416 IMMUNE SYSTEM STRUCTURE OF A HUMAN BENCE-JONES DIMER CRYSTALLIZED IN U.S. SPACE SHUTTLE MISSION STS-95: 293K ? LAMBDA ? HOMO SAPIENS 14 TGVSSIVGSYNLVS 7 EVNKRPS 11 SSYDGSSTSVV 0 N/A 0 N/A 0 N/A crystal 2.30A 17.30% LC-dimer 17-APR-02 20020417 IMMUNOGLOBULIN BENCE JONES PROTEIN CLE, A LAMBDA III IMMUNOGLOBULIN LIGHT- CHAIN DIMER MOLECULE: LAMBDA III BENCE JONES PROTEIN CLE; LAMBDA ? HOMO SAPIENS 11 SGEKLGDAYVC 7 QDNRRPS 10 QVWDSNASVV 0 N/A 0 N/A 0 N/A crystal 2.65A 20.00% LC-dimer 13-MAY-96 19960513 IMMUNE SYSTEM ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT MOLECULE: INTERLEUKIN-10; FRAGMENT: RESIDUES 26-175; SYNONYM: IL-10M1 (ENGINEERED MONOMER OF HUMAN INTERLEUKIN- 10), IL-10, CYTOKINE SYNTHESIS INHIBITORY FACTOR, CSIF; ENGINEERED: YES; ? ? RATTUS NORVEGICUS 11 KASESVTSRMH 7 KASNLAS 9 QQSWNGPLT 5 DFYIH 17 YINPNSGYTNYNEKFKN 10 GVPGNNWFPY crystal 1.91A 18.70% FAB 23-APR-02 20020423 IMMUNOGLOBULIN THE STRUCTURE OF A BIVALENT DIABODY MOLECULE: ANTI-PHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE C DIABODY; ENGINEERED: YES ? ? MUS MUSCULUS 0 N/A 0 N/A 0 N/A 5 NYWIE 17 KILPGGGSNTYNDKFKG 26 GEDYYAYWYVLDYWGQGTTVTVSSGG crystal 2.60A 20.00% HC-dimer 29-AUG-94 19940829 IMMUNE SYSTEM CATALYTIC RETRO-DIELS-ALDERASE TRANSITION STATE ANALOGUE COMPLEX MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 TSSQTIVHTNGNTYLE 7 KVSNRFS 9 FQGSHFPLA 5 NYGMS 16 SISYGGLIYYPDSIKG 10 GDSFLVWFTF crystal 2.00A 20.60% FAB 05-MAY-02 20020505 IMMUNE SYSTEM RETRO-DIELS-ALDERASE CATALYTIC ANTIBODY MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 TSSQTIVHTNGNTYLE 7 KVSNRFS 9 FQGSHFPLA 5 NYGMS 16 SISYGGLIYYPDSIKG 10 GDSFLVWFTF crystal 2.00A 21.00% FAB 06-MAY-02 20020506 IMMUNE SYSTEM RETRO-DIELS-ALDERASE CATALYTIC ANTIBODY: PRODUCT ANALOGUE MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 TSSQTIVHTNGNTYLE 7 KVSNRFS 9 FQGSHFPLA 5 NYGMS 16 SISYGGLIYYPDSIKG 10 GDSFLVWFTF crystal 2.30A 20.80% FAB 06-MAY-02 20020506 IMMUNE SYSTEM RETRO-DIELS-ALDERASE CATALYTIC ANTIBODY 9D9 MOLECULE: IG GAMMA 2A HEAVY CHAIN; KAPPA ? MUS MUSCULUS 16 RSSQTIVHTNGNTYFE 7 KVSNRLS 9 FQGSHSPWT 5 TYGMS 16 SISYGGLLYFSDSVKG 10 GTSFVRYFDV crystal 2.40A 23.90% FAB 06-MAY-02 20020506 IMMUNE SYSTEM THE CRYSTAL STRUCTURE OF IGE FC REVEALS AN ASYMMETRICALLY BENT CONFORMATION ? ? IGE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; GENE: IGE(ND); EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: MOUSE; EXPRESSION_SYSTEM_CELL_LINE: MOUSE MYELOMA NS0; EXPRESSION_SYSTEM_VECTOR_TYPE: EUKARYOTIC; EXPRESSION_SYSTEM_VECTOR: PEE6 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A 0 N/A crystal 2.60A 21.80% FC 16-MAY-02 20020516 LEN, A VARIABLE DOMAIN FROM IMMUNOGLOBULIN LIGHT-CHAIN (BENCE-JONES PROTEIN) ? ? ? HUMAN (HOMO SAPIENS) 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 1.80A 24.00% LC-dimer 19-JUL-94 19940719 IMMUNOGLOBULIN STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K- 4 LIGHT CHAIN LEN ? KAPPA ? MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN; ORGANISM_TAXID: 9606 17 KSSQSVLYSSNSKNYLA 7 WASTRES 9 QQYYSTPYS 0 N/A 0 N/A 0 N/A crystal 1.95A 15.00% LC-dimer 17-JUL-96 19960717 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE ? ? ? MUS MUSCULUS 16 RSSQSLLHSDGNTYLH 7 KVSNRFS 8 SQTTHVPT 5 NYWME 19 EIRLKSNNYATHYAESVKG 9 GGAVGAMDY crystal 2.80A 22.30% FAB 18-JUL-02 20020718 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE COMPLEXED WITH A TRISACCHARIDE A TRISACCHARIDE ? ? MUS MUSCULUS 16 RSSQSLLHSDGNTYLH 7 KVSNRFS 8 SQTTHVPT 5 NYWME 19 EIRLKSNNYATHYAESVKG 9 GGAVGAMDY crystal 2.30A 21.60% FAB 19-JUL-02 20020719 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE COMPLEXED WITH A PENTASACCHARIDE A PENTASACCHARIDE ? ? MUS MUSCULUS 16 RSSQSLLHSDGNTYLH 7 KVSNRFS 8 SQTTHVPT 5 NYWME 19 EIRLKSNNYATHYAESVKG 9 GGAVGAMDY crystal 2.50A 22.00% FAB 19-JUL-02 20020719 IMMUNOGLOBULIN SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN ? KAPPA IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 0 N/A 0 N/A 0 N/A NMR N/A N/A LC-dimer 16-SEP-93 19930916 IMMUNOGLOBULIN SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN ? KAPPA IGG2 MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090 16 RSSQSLVHSNGNTYLN 7 KVSNRFS 9 SQTTHVPPT 0 N/A 0 N/A 0 N/A NMR N/A N/A LC-dimer 16-SEP-93 19930916 IMMUNOGLOBULIN CRYSTAL STRUCTURE TO 2.45 A RESOLUTION OF A MONOCLONAL FAB SPECIFIC FOR THE BRUCELLA A CELL WALL POLYSACCHARIDE ANTIGEN ? KAPPA IGG2 MUS MUSCULUS 11 RASQDIYNYLN 7 YTSRLHS 9 QQGNTLPFT 5 DYYMS 19 FIRNKADGYTTEYSASVKG 8 DPYGPAAY crystal 2.45A 21.50% FAB 14-JAN-92 19920114 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-OH; ENGINEERED: YES LAMBDA ? PHOCA VITULINA 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 20.40% LC-dimer 25-FEB-93 19930225 IMMUNE SYSTEM PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.90% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-D-PHE-B-ALA-L-HIS-D-PRO-NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.00% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-B-ALA- OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.10% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-B-ALA-B- ALA-OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.40% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-B-ALA-B- ALA-OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 25.20% LC-dimer 25-FEB-93 19930225 IMMUNE SYSTEM PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-D-PHE-L-HIS-D-PRO-OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 17.70% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-D-PHE-L-HIS-D-PRO-NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 19.30% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-D-GLU-L-HIS-D-PRO-NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.90% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: N-ACETYL-D-HIS-L-PRO-OH; ENGINEERED: YES LAMBDA ? 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.90% LC-dimer 25-FEB-93 19930225 IMMUNE SYSTEM PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-D-HIS-L-PRO-NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.30% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION ? ? IGG1 HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 7 TILYYWS 16 YIYYSGSTYGNPSLKS 7 VPLVVNP crystal 3.20A 23.20% ? 25-FEB-93 19930225 IMMUNOGLOBULIN PHOSPHOCHOLINE BINDING IMMUNOGLOBULIN FAB MC/PC603. AN X- RAY DIFFRACTION STUDY AT 2.7 ANGSTROMS ? KAPPA IGA MUS MUSCULUS 17 KSSQSLLNSGNQKNFLA 7 GASTRES 9 QNDHSYPLT 5 DFYME 19 ASRNKGNKYTTEYSASVKG 11 NYYGSTWYFDV crystal 2.70A 22.50% FAB 09-JUL-84 19840709 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-HIS-D-PRO-NH2; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 20.40% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-HIS-D-PRO-OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 20.40% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS MOLECULE: PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-OH; ENGINEERED: YES LAMBDA ? HOMO SAPIENS 14 TGTSSDVGGYNYVS 7 EVNKRPS 10 SSYEGSDNFV 0 N/A 0 N/A 0 N/A crystal 2.70A 18.30% LC-dimer 25-FEB-93 19930225 IMMUNOGLOBULIN THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY ? ? ? HOMO SAPIENS 14 AGHTSDVADSNSIS 7 AVTFRPS 10 MSYLSDASFV 0 N/A 0 N/A 0 N/A crystal 3.50A 17.00% LC-dimer 09-MAY-89 19890509 COMPLEX (ANTIBODY/ANTIGEN) CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME MOLECULE: LYSOZYME; EC: 3.2.1.17; ENGINEERED: YES ? ? CAMELUS DROMEDARIUS 0 N/A 0 N/A 0 N/A 5 PYCMG 17 AINMGGGITYYADSVKG 24 DSTIYASYYECGHGLSTGGYGYDS crystal 2.50A 22.10% HC-dimer 06-JUN-96 19960606 IMMUNOGLOBULIN ANTI HIV1 PROTEASE FAB COMPLEX IMMUNOGLOBULIN ANTI HIV1 PROTEASE FAB COMPLEX ? IGG1 MUS MUSCULUS 15 RASESVDYYGKSFMN 7 AASNQGS 9 QQSKEVPWT 5 RFGMH 17 YISSGSSTIYYADTVKG 16 SGGIERYDGTYYVMDY crystal 2.60A 20.60% FAB 27-DEC-96 19961227 IMMUNOGLOBULIN STRUCTURE OF A SINGLE-CHAIN FV FRAGMENT COMPLEXED WITH A CARBOHYDRATE ANTIGEN AT 1.7 ANGSTROMS RESOLUTION A CARBOHYDRATE ANTIGEN AT 1.7 ANGSTROMS RESOLUTION LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWSNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 1.70A 16.60% FV 25-OCT-93 19931025 IMMUNOGLOBULIN HIGH RESOLUTION STRUCTURES OF ANTIBODY FAB FRAGMENT COMPLEXED WITH CELL-SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA CELL-SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.10A 16.00% FAB 25-OCT-93 19931025 IMMUNOGLOBULIN HIGH RESOLUTION STRUCTURES OF ANTIBODY FAB FRAGMENT COMPLEXED WITH CELL-SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA CELL-SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.10A 16.30% FAB 25-OCT-93 19931025 IMMUNOGLOBULIN THE SOLUTION STRUCTURE OF A TRISACCHARIDE-ANTIBODY COMPLEX: COMPARISON OF NMR MEASUREMENTS WITH A CRYSTAL STRUCTURE : COMPARISON OF NMR MEASUREMENTS WITH A CRYSTAL STRUCTURE LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.10A 18.30% FAB 25-OCT-93 19931025 IMMUNOGLOBULIN RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT ? LAMBDA IGG1 MUS MUSCULUS 14 RSSTGTVTSGNHAN 7 DTNNRAP 9 ALWCNNHWI 5 NYWMH 17 AIYPGNSATFYNHKFRA 9 GGHGYYGDY crystal 2.00A 18.50% FAB 25-OCT-93 19931025 IMMUNE SYSTEM THE STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6-164 AND A TRANSITION-STATE ANALOG OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6-164 AND A TRANSITION-STATE ANALOG ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 SNWIN 17 NIYPDSYRTNYNEKFKR 10 KHYSYDGVVY crystal 2.10A 21.80% FAB 19-AUG-02 20020819 IMMUNE SYSTEM ANTIBODY-ANTIGEN COMPLEX MOLECULE: PROTEIN L DOMAIN C; ENGINEERED: YES; MUTATION: YES ? ? MUS MUSCULUS 17 KSSQSLLNSRTRKNYLA 7 WASTRES 9 KQAYIPPLT 5 DFSMH 17 WVNTETGEPTYADDFKG 9 FLLRQYFDV crystal 2.10A 19.70% FAB 20-AUG-02 20020820 IMMUNE SYSTEM CRYSTAL STRUCTURE OF A CHIMERIC ALPHA1 INTEGRIN I-DOMAIN IN COMPLEX WITH THE FAB FRAGMENT OF A HUMANIZED NEUTRALIZING ANTIBODY MOLECULE: INTEGRIN ALPHA 1, (RESIDUES 169-360); FRAGMENT: ALPHA1 I-DOMAIN; SYNONYM: LAMININ AND COLLAGEN RECEPTOR, VLA-1, CD49A; ENGINEERED: YES; MUTATION: YES; ? ? MUS MUSCULUS 10 SASSSVNHMF 7 LTSNLAS 9 QQWSGNPWT 5 RYTMS 16 TISGGGHTYYLDSVKG 10 GFGDGGYFDV crystal 2.80A 22.20% FAB 20-AUG-02 20020820 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS5-393 MOLECULE: IMMUNOGLOBULIN MS5-393; FRAGMENT: FAB FRAGMENT, HEAVY CHAIN; ENGINEERED: YES ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090; CELL_LINE: HYBRIDOMA; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; OTHER_DETAILS: FUSING OF MOUSE SPLENOCYTES WITH MYELOMA CELL; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090; CELL_LINE: HYBRIDOMA; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; OTHER_DETAILS: FUSING OF MOUSE SPLENOCYTES WITH MYELOMA CELL 16 RSSKSLLHSNGNTYLN 7 RMSNLAS 9 MQHLEYPFT 0 N/A 0 N/A 0 N/A crystal 1.95A 21.90% LC-dimer 23-AUG-02 20020823 IMMUNOGLOBULIN IGG FAB FRAGMENT (CD25-BINDING) ? KAPPA IGG HOMO SAPIENS 10 SASSSRSYMQ 7 DTSKLAS 7 HQRSSYT 5 RYWMH 17 AIYPGNSDTSYNQKFEG 8 DYGYYFDF crystal 2.60A 19.60% FAB 04-DEC-95 19951204 IMMUNE SYSTEM CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS5-393 AND A TRANSITION-STATE ANALOG MOLECULE: IMMUNOGLOBULIN MS5-393; FRAGMENT: FAB FRAGMENT, HEAVY CHAIN; ENGINEERED: YES ? ? MOL_ID: 1; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090; CELL_LINE: HYBRIDOMA; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; OTHER_DETAILS: FUSING OF MOUSE SPLENOCYTES WITH MYELOMA CELL; MOL_ID: 2; ORGANISM_SCIENTIFIC: MUS MUSCULUS; ORGANISM_COMMON: HOUSE MOUSE; ORGANISM_TAXID: 10090; CELL_LINE: HYBRIDOMA; EXPRESSION_SYSTEM: MUS MUSCULUS; EXPRESSION_SYSTEM_COMMON: HOUSE MOUSE; EXPRESSION_SYSTEM_TAXID: 10090; OTHER_DETAILS: FUSING OF MOUSE SPLENOCYTES WITH MYELOMA CELL 16 RSSKSLLHSNGNTYLN 7 RMSNLAS 9 MQHLEYPFT 0 N/A 0 N/A 0 N/A crystal 2.25A 20.00% LC-dimer 27-AUG-02 20020827 IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6-126 ? ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 SNWIN 17 NIYPGSGYTNYNERFKS 10 KHYFYDGVVY crystal 1.75A 15.50% FAB 27-AUG-02 20020827 IMMUNE SYSTEM HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12 AND A TRANSITION- STATE ANALOG OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12 AND A TRANSITION- STATE ANALOG ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 NYWIN 17 NIYPGSSYTHYNEKFKN 7 KLGWFPY crystal 2.10A 17.80% FAB 28-AUG-02 20020828 IMMUNE SYSTEM 1.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12 ? ? ? MUS MUSCULUS 16 RSSKSLLHSNGNTYLY 7 RMSNLAS 9 LQHLEYPFT 5 NYWIN 17 NIYPGSSYTHYNEKFKN 7 KLGWFPY crystal 1.22A 12.30% FAB 28-AUG-02 20020828 IMMUNOGLOBULIN MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG- WHITE LYSOZYME ? KAPPA IGG1 11 RASQSISNNLH 7 YVSQSSS 9 QQSNSWPRT 5 TYWIE 17 EILPGSGSTYYNEKFKG 7 GDGNYGY crystal 2.10A 18.10% FAB 08-MAR-95 19950308 COMPLEX (ANTIBODY/ANTIGEN) MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG- WHITE LYSOZYME COMPLEXED WITH LYSOZYME MOLECULE: HEN EGG WHITE LYSOZYME; ENGINEERED: YES KAPPA IGG1 MUS MUSCULUS 11 RASQSISNNLH 7 YVSQSSS 9 QQSNSWPRT 5 TYWIE 17 EILPGSGSTYYNEKFKG 7 GDGNYGY crystal 2.50A 18.40%