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G6PD: Introduction

Hereditary deficiency in human Glucose-6-phosphate dehydrogenase (G6PD)is estimated to affect about 400 million worldwide. The highest prevalence rates are found in tropical Africa, the Middle East, tropical and sub-tropical Asia, some parts of the Mediterranean and in Papua New Guinea.

The database

The web-accessible database is an integration of up-to-date mutational and structural data from various genetic and structural databases (Genbank, Protein Data Bank, etc.) and latest publications. An automated analysis of mutations likely to have a significant impact on the structure of the protein has also been performed. This procedure identifies mutations which distort secondary structure, destroy hydrogen bonding and electrostatic interactions or simply cause bad clashes. Residues involved in the active site and the dimer interface and residues conserved among the G6PDs of different species are also identified.

This database can provide both science researchers and clinicians insights into the molecular aspects and clinical significance of G6PD deficiency. It also facilitates the understanding of the structure and function relationships of the enzyme.

Please note!

We are a Bioinformatics lab with an interest in how mutations affect protein structure and function. We are not a clinical group and cannot offer any assistance with the clinical aspects of living with Favism.

Veronica Lam

These pages are dedicated to Dr. Veronica Lam who died in the Asian tsunami disaster on 26th December 2004