SOD1 Motor Neurone Disease Mutations

This database analyses the effect of amino acid alterations in a set of motor neurone disease associated proteins.


Explantions for Disease Mutations

Total Number of Mutations: 96
Total Number of Mutations Explained: 88
Total Number of Mutations Explained by binding: 7
Total Number of Mutations Explained by Proline: 0
Total Number of Mutations Explained by clash: 24
Total Number of Mutations Explained by void: 22
Total Number of Mutations Explained by interface: 69
Total Number of Mutations Explained by hbond: 24
Total Number of Mutations Explained by gly: 20

Explantions for Random Mutations

Total Number of Mutations: 1056
Total Number of Mutations Explained: 954
Total Number of Mutations Explained by binding: 163
Total Number of Mutations Explained by Proline: 42
Total Number of Mutations Explained by clash: 269
Total Number of Mutations Explained by void: 192
Total Number of Mutations Explained by interface: 770
Total Number of Mutations Explained by hbond: 377
Total Number of Mutations Explained by gly: 135

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The search term may be one of the following:
Mutation ID (Disease-Causing Search only), eg 120150 (OMIM data), Alabama (G6PD data)
For an exact match to a gene symbol, prefix it with an equals sign, eg =G6PD
PDB ID, eg 9gss, 6gss
Swiss-Prot ID, eg P05787
Further Details