SAAPdap/SAAPpred - Single Amino Acid Polymorphism data analysis pipeline and predictor

If you wish to run SAAPpred, you must run SAAPdap first!

03.10.18 Note that some analyses and predictions may not have included sequence-based features over the last few months as a result of the EBI changing from http to https. This has now been fixed.

SAAPdap allows you to run the SAAP mutation analysis pipeline to examine the likely local structural effects of a mutation. Consequently it can only be used where a structure is known for the protein of interest.

You have the choice of entering a mutation for a UniProt sequence (in which case the server will find the appropriate PDB protein structures) or analyzing a mutation in a specified PDB file.

Note that if you specify a mutation in a UniProt sequence, the web server will only analyze a maximum of two structures that represent your sequence. In future we will allow users to register to analyze all structures.

UniProt PDB

UniProt Accession e.g. P12883
Native Residue e.g. ser
Residue Number e.g. 242
Mutant Residue e.g. glu

The analysis (particularly of voids in large proteins) is slow and can take several minutes! Please be patient!

Progress on the analysis will appear here...

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